WEN-HSIANG CHEN

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
Houston, TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pino M, Abid T, Pereira Ribeiro S, Edara VV, Floyd K, Smith JC, Latif MB, Pacheco-Sanchez G, Dutta D, Wang S, Gumber S, Kirejczyk S, Cohen J, Stammen RL, Jean SM, Wood JS, Connor-Stroud F, Pollet J, Chen WH, Wei J, Zhan B, Lee J, Liu Z, Strych U, Shenvi N, Easley K, Weiskopf D, Sette A, Pollara J, Mielke D, Gao H, Eisel N, LaBranche CC, Shen X, Ferrari G, Tomaras GD, Montefiori DC, Sekaly RP, Vanderford TH, Tomai MA, Fox CB, Suthar MS, Kozlowski PA, Hotez PJ, Paiardini M, Bottazzi ME, Kasturi SP. A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates. Sci Immunol. 2021 07 15; 6(61). PMID: 34266981.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Pollet J, Strych U, Chen WH, Versteeg L, Keegan B, Zhan B, Wei J, Liu Z, Lee J, Kundu R, Adhikari R, Poveda C, Villar MJ, Lopez B, Gillespie PM, Ronca S, Kimata JT, Reers M, Paradkar V, Hotez PJ, Bottazzi ME. Receptor-binding domain recombinant protein RBD219-N1C1 on alum-CpG induces broad protection against SARS-CoV-2 variants of concern. bioRxiv. 2021 Jul 07. PMID: 34268512.
      Citations: 1     
    3. Lee J, Liu Z, Chen WH, Wei J, Kundu R, Adhikari R, Rivera JA, Gillespie PM, Strych U, Zhan B, Hotez PJ, Bottazzi ME. Process development and scale-up optimization of the SARS-CoV-2 receptor binding domain-based vaccine candidate, RBD219-N1C1. Appl Microbiol Biotechnol. 2021 May; 105(10):4153-4165. PMID: 33959781.
      Citations: 2     Fields:    Translation:HumansAnimals
    4. Pollet J, Chen WH, Versteeg L, Keegan B, Zhan B, Wei J, Liu Z, Lee J, Kundu R, Adhikari R, Poveda C, Villar MJ, de Araujo Leao AC, Altieri Rivera J, Momin Z, Gillespie PM, Kimata JT, Strych U, Hotez PJ, Bottazzi ME. SARS-CoV-2 RBD219-N1C1: A yeast-expressed SARS-CoV-2 recombinant receptor-binding domain candidate vaccine stimulates virus neutralizing antibodies and T-cell immunity in mice. Hum Vaccin Immunother. 2021 08 03; 17(8):2356-2366. PMID: 33847226.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    5. Chen WH, Wei J, Kundu RT, Adhikari R, Liu Z, Lee J, Versteeg L, Poveda C, Keegan B, Villar MJ, de Araujo Leao AC, Rivera JA, Gillespie PM, Pollet J, Strych U, Zhan B, Hotez PJ, Bottazzi ME. Genetic modification to design a stable yeast-expressed recombinant SARS-CoV-2 receptor binding domain as a COVID-19 vaccine candidate. Biochim Biophys Acta Gen Subj. 2021 06; 1865(6):129893. PMID: 33731300.
      Citations: 5     Fields:    Translation:AnimalsCells
    6. Pollet J, Chen WH, Versteeg L, Keegan B, Zhan B, Wei J, Liu Z, Lee J, Kundu R, Adhikari R, Poveda C, Villar MJ, de Araujo Leao AC, Rivera JA, Momin Z, Gillespie PM, Kimata JT, Strych U, Hotez PJ, Bottazzi ME. SARS-CoV-2 RBD219-N1C1: A Yeast-Expressed SARS-CoV-2 Recombinant Receptor-Binding Domain Candidate Vaccine Stimulates Virus Neutralizing Antibodies and T-cell Immunity in Mice. bioRxiv. 2021 Feb 09. PMID: 33173864.
      Citations: 4     
    7. Pollet J, Chen WH, Strych U. Recombinant protein vaccines, a proven approach against coronavirus pandemics. Adv Drug Deliv Rev. 2021 03; 170:71-82. PMID: 33421475.
      Citations: 9     Fields:    Translation:HumansAnimalsPHPublic Health
    8. Chen WH, Tao X, Agrawal AS, Algaissi A, Peng BH, Pollet J, Strych U, Bottazzi ME, Hotez PJ, Lustigman S, Du L, Jiang S, Tseng CK. Yeast-expressed SARS-CoV recombinant receptor-binding domain (RBD219-N1) formulated with aluminum hydroxide induces protective immunity and reduces immune enhancement. Vaccine. 2020 11 03; 38(47):7533-7541. PMID: 33039209.
      Citations: 21     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    9. Liu Z, Kundu R, Damena S, Biter AB, Nyon MP, Chen WH, Zhan B, Strych U, Hotez PJ, Bottazzi ME. A scalable and reproducible manufacturing process for Phlebotomus papatasi salivary protein PpSP15, a vaccine candidate for leishmaniasis. Protein Expr Purif. 2021 01; 177:105750. PMID: 32920041.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    10. Chen WH, Tao X, Agrawal A, Algaissi A, Peng BH, Pollet J, Strych U, Bottazzi ME, Hotez PJ, Lustigman S, Du L, Jiang S, Tseng CK. Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1) Formulated with Aluminum Hydroxide Induces Protective Immunity and Reduces Immune Enhancement. bioRxiv. 2020 Jul 05. PMID: 32511385.
      Citations:    
    11. Marcinkiewicz AL, Lieknina I, Yang X, Lederman PL, Hart TM, Yates J, Chen WH, Bottazzi ME, Mantis NJ, Kraiczy P, Pal U, Tars K, Lin YP. The Factor H-Binding Site of CspZ as a Protective Target against Multistrain, Tick-Transmitted Lyme Disease. Infect Immun. 2020 04 20; 88(5). PMID: 32122944.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    12. Chen WH, Hotez PJ, Bottazzi ME. Potential for developing a SARS-CoV receptor-binding domain (RBD) recombinant protein as a heterologous human vaccine against coronavirus infectious disease (COVID)-19. Hum Vaccin Immunother. 2020 06 02; 16(6):1239-1242. PMID: 32298218.
      Citations: 33     Fields:    Translation:HumansCellsPHPublic Health
    13. Chen WH, Strych U, Hotez PJ, Bottazzi ME. The SARS-CoV-2 Vaccine Pipeline: an Overview. Curr Trop Med Rep. 2020 Mar 03; 1-4. PMID: 32219057.
      Citations: 181     
    14. Chen WH, Nyon MP, Poongavanam MV, Liu Z, Biter AB, Kundu RT, Strych U, Hotez PJ, Bottazzi ME. Process Characterization and Biophysical Analysis for a Yeast-Expressed Phlebotomus papatasi Salivary Protein (PpSP15) as a Leishmania Vaccine Candidate. J Pharm Sci. 2020 05; 109(5):1673-1680. PMID: 32070701.
      Citations: 1     Fields:    Translation:Animals
    15. Biter AB, Pollet J, Chen WH, Strych U, Hotez PJ, Bottazzi ME. A method to probe protein structure from UV absorbance spectra. Anal Biochem. 2019 12 15; 587:113450. PMID: 31550438.
      Citations:    Fields:    Translation:Cells
    16. Biter AB, Weltje S, Hudspeth EM, Seid CA, McAtee CP, Chen WH, Pollet JB, Strych U, Hotez PJ, Bottazzi ME. Characterization and Stability of Trypanosoma cruzi 24-C4 (Tc24-C4), a Candidate Antigen for a Therapeutic Vaccine Against Chagas Disease. J Pharm Sci. 2018 05; 107(5):1468-1473. PMID: 29274820.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    17. Chen WH, Chag SM, Poongavanam MV, Biter AB, Ewere EA, Rezende W, Seid CA, Hudspeth EM, Pollet J, McAtee CP, Strych U, Bottazzi ME, Hotez PJ. Optimization of the Production Process and Characterization of the Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1), a SARS Vaccine Candidate. J Pharm Sci. 2017 08; 106(8):1961-1970. PMID: 28456726.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    18. Hotez PJ, Bottazzi ME, Zhan B, Chen W-H, Chag S . A novel SARS immunogenic composition. 2016. View Publication.
    19. Kisley L, Chen J, Mansur AP, Shuang B, Kourentzi K, Poongavanam MV, Chen WH, Dhamane S, Willson RC, Landes CF. Unified superresolution experiments and stochastic theory provide mechanistic insight into protein ion-exchange adsorptive separations. Proc Natl Acad Sci U S A. 2014 Feb 11; 111(6):2075-80. PMID: 24459184.
      Citations: 9     Fields:    Translation:Cells
    20. Chen WH, Du L, Chag SM, Ma C, Tricoche N, Tao X, Seid CA, Hudspeth EM, Lustigman S, Tseng CT, Bottazzi ME, Hotez PJ, Zhan B, Jiang S. Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate. Hum Vaccin Immunother. 2014; 10(3):648-58. PMID: 24355931.
      Citations: 46     Fields:    Translation:AnimalsCells
    21. Dhamane S, Ruiz-Ruiz F, Chen WH, Kourentzi K, Benavides J, Rito-Palomares M, Willson RC. Spermine Sepharose as a clustered-charge anion exchange adsorbent. J Chromatogr A. 2014 Jan 10; 1324:135-40. PMID: 24296294.
      Citations:    Fields:    Translation:AnimalsCells
    22. Adhikari M, Dhamane S, Hagström AE, Garvey G, Chen WH, Kourentzi K, Strych U, Willson RC. Functionalized viral nanoparticles as ultrasensitive reporters in lateral-flow assays. Analyst. 2013 Oct 07; 138(19):5584-7. PMID: 23905160.
      Citations: 10     Fields:    Translation:HumansCells
    23. Kanakaraj I, Chen WH, Poongavanam M, Dhamane S, Stagg LJ, Ladbury JE, Kourentzi K, Strych U, Willson RC. Biophysical characterization of VEGF-aHt DNA aptamer interactions. Int J Biol Macromol. 2013 Jun; 57:69-75. PMID: 23470436.
      Citations: 1     Fields:    Translation:HumansAnimals
    24. Daniels CR, Kisley L, Kim H, Chen WH, Poongavanam MV, Reznik C, Kourentzi K, Willson RC, Landes CF. Fluorescence correlation spectroscopy study of protein transport and dynamic interactions with clustered-charge peptide adsorbents. J Mol Recognit. 2012 Aug; 25(8):435-42. PMID: 22811068.
      Citations: 4     Fields:    Translation:Cells
    25. Daniels CR, Reznik C, Kilmer R, Felipe MJ, Tria MC, Kourentzi K, Chen WH, Advincula RC, Willson RC, Landes CF. Permeability of anti-fouling PEGylated surfaces probed by fluorescence correlation spectroscopy. Colloids Surf B Biointerfaces. 2011 Nov 01; 88(1):31-8. PMID: 21742471.
      Citations: 5     Fields:    
    26. Chen WH, Fu JY, Kourentzi K, Willson RC. Nucleic acid affinity of clustered-charge anion exchange adsorbents: effects of ionic strength and ligand density. J Chromatogr A. 2011 Jan 14; 1218(2):258-62. PMID: 21159348.
      Citations: 4     Fields:    Translation:AnimalsCells
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