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WAH CHIU

TitleAdjunct Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology
AddressOne Baylor Plaza
Houston TX 77030
Email
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    Other Positions
    TitleAdjunct Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Biochemistry & Molecular Biology
    DivisionBiochemistry & Molecular Biology

    TitleAdjunct Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Virology & Microbiology
    DivisionMolecular Virology & Microbiology


    Collapse Biography 
    Collapse awards and honors
    2015Barbara and Corbin J. Robertson Jr. Presidential Award for Excellence in Education, Baylor College of Medicine
    2008Elected Academician of Academia Sinica, Taiwan, Academia Sinica, Taiwan
    2012Elected Member of National Academy of Sciences, United States National Academy of Sciences
    2013Elected Member of Academy of Medicine, Engineering, and Science of Texas, The Academy of Medicine, Engineering, and Science of Texas
    2013Distinguished Faculty Award of Baylor College of Medicine Alumni Association , Baylor College of Medicine Alumni Association
    1996Alexander von Humboldt Research Prize, Alexander von Humboldt Foundation
    2010Distinguished Service Professor, Baylor College of Medicine, Baylor College of Medicine
    2014Honorary Doctorate of Philosophy at the University of Helsinki, University of Helsinki
    2014Microscopy Society of America Distinguished Scientist Award , Microscopy Society of America

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    R01GM027061     (CHIU, WAH)May 1, 1979 - Jun 30, 1991
    NIH/NIGMS
    ELECTRON MICROSCOPY ANALYSIS OF DNA BINDING PROTEIN
    Role: Principal Investigator

    R01NS016047     (CHIU, WAH)Mar 1, 1980 - Feb 28, 1986
    NIH/NINDS
    STRUCTURAL STUDY OF NEUROTOXINS BY ELECTRON DIFFRACTION
    Role: Principal Investigator

    P41RR002250     (CHIU, WAH)Mar 1, 1985 - Dec 31, 2014
    NIH/NCRR
    3 D Electron Microscopy of Macromolecules
    Role: Principal Investigator

    R13RR002626     (CHIU, WAH)Jul 7, 1985 - Jun 30, 1986
    NIH/NCRR
    3-DIMENSIONAL ELECTRON MICROSCOPY OF MACROMOLECULES
    Role: Principal Investigator

    R01NS025877     (CHIU, WAH)Jul 1, 1987 - Feb 28, 1993
    NIH/NINDS
    STRUCTURE-FUNCTION ANALYSIS OF ENVELOPED VIRUSES
    Role: Principal Investigator

    R01GM041064     (CHIU, WAH)Dec 1, 1988 - Nov 30, 1993
    NIH/NIGMS
    STRUCTURAL STUDIES OF ROTAVIRUSES
    Role: Principal Investigator

    R01AI038469     (CHIU, WAH)Sep 30, 1995 - Feb 28, 2007
    NIH/NIAID
    Structural Studies of Herpesvirus Capsids
    Role: Principal Investigator

    P41GM103832     (CHIU, WAH)Dec 1, 1996 - Dec 31, 2019
    NIH/NIGMS
    3 D Electron Microscopy of Macromolecules
    Role: Principal Investigator

    R13RR013610     (CHIU, WAH)Dec 1, 1998 - Nov 30, 1999
    NIH/NCRR
    ELECTRON CRYSTALLOGRAPHY OF MACROMOLECULES
    Role: Principal Investigator

    R01AI043656     (CHIU, WAH)Mar 1, 1999 - Feb 28, 2003
    NIH/NIAID
    STRUCTURAL BASIS OF BACTERIOPHAGE P22 ASSEMBLY
    Role: Principal Investigator

    R21AI053737     (CHIU, WAH)Sep 15, 2002 - Nov 30, 2004
    NIH/NIAID
    High throughput icosahedral particle reconstruction
    Role: Principal Investigator

    R01GM070557     (CHIU, WAH)May 1, 2004 - Apr 30, 2008
    NIH/NIGMS
    Icosahedral Particle Reconstruction Software
    Role: Principal Investigator

    P20RR020647     (CHIU, WAH)Sep 29, 2004 - Jul 31, 2009
    NIH/NCRR
    Computation Center for Biomolecular Complexes (RMI)
    Role: Principal Investigator

    PN1EY016525     (CHIU, WAH)Sep 30, 2004 - Jul 31, 2005
    NIH/NEI
    Center for Protein Folding Machinery (RMI)
    Role: Principal Investigator

    PN2EY016525     (CHIU, WAH)Sep 30, 2004 - Jul 31, 2016
    NIH/NEI
    Center for Protein Folding Machinery
    Role: Principal Investigator

    R01GM079429     (CHIU, WAH)Aug 15, 2007 - Jan 31, 2022
    NIH/NIGMS
    Unified Data Resource for 3DEM
    Role: Principal Investigator

    R01AI075208     (CHIU, WAH)May 22, 2009 - Apr 30, 2012
    NIH/NIAID
    Structures of the portal vertex in dsDNA viruses and virus-infected cells
    Role: Principal Investigator

    R56AI075208     (CHIU, WAH)May 22, 2009 - Aug 31, 2013
    NIH/NIAID
    Structures of the portal vertex in dsDNA viruses and virus-infected cells
    Role: Principal Investigator

    RC2GM092599     (CHIU, WAH)Sep 30, 2009 - Aug 31, 2012
    NIH/NIGMS
    Subcellular localization of nanoparticles
    Role: Principal Investigator

    S10OD021600     (CHIU, WAH)Jul 1, 2016 - Jun 30, 2017
    NIH
    Acquisition of a 300 kV Electron Microscope for Structural Biology
    Role: Principal Investigator

    U24GM116787     (CHIU, WAH)Jul 15, 2016 - Jun 30, 2021
    NIH/NIGMS
    CryoEM Data Collection Facility Consortium at NCM
    Role: Principal Investigator

    U24GM129541     (CHIU, WAH)May 1, 2018 - Apr 30, 2024
    NIH/NIGMS
    The Stanford-SLAC CryoEM Center
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Gestaut D, Roh SH, Ma B, Pintilie G, Joachimiak LA, Leitner A, Walzthoeni T, Aebersold R, Chiu W, Frydman J. The Chaperonin TRiC/CCT Associates with Prefoldin through a Conserved Electrostatic Interface Essential for Cellular Proteostasis. Cell. 2019 Mar 22. PMID: 30955883.
      View in: PubMed
    2. Zhang K, Zhang H, Li S, Pintilie GD, Mou TC, Gao Y, Zhang Q, van den Bedem H, Schmid MF, Au SWN, Chiu W. Cryo-EM structures of Helicobacter pylori vacuolating cytotoxin A oligomeric assemblies at near-atomic resolution. Proc Natl Acad Sci U S A. 2019 Apr 02; 116(14):6800-6805. PMID: 30894496.
      View in: PubMed
    3. Guo M, Zhang K, Zhu Y, Pintilie GD, Guan X, Li S, Schmid MF, Ma Z, Chiu W, Huang Z. Coupling of ssRNA cleavage with DNase activity in type III-A CRISPR-Csm revealed by cryo-EM and biochemistry. Cell Res. 2019 Apr; 29(4):305-312. PMID: 30814678.
      View in: PubMed
    4. Zhang YX, Chiu WT, Costa NC, Batrouni GG, Scalettar RT. Charge Order in the Holstein Model on a Honeycomb Lattice. Phys Rev Lett. 2019 Feb 22; 122(7):077602. PMID: 30848616.
      View in: PubMed
    5. Jun H, Shepherd TR, Zhang K, Bricker WP, Li S, Chiu W, Bathe M. Automated Sequence Design of 3D Polyhedral Wireframe DNA Origami with Honeycomb Edges. ACS Nano. 2019 Feb 26; 13(2):2083-2093. PMID: 30605605.
      View in: PubMed
    6. Dosey TL, Wang Z, Fan G, Zhang Z, Serysheva II, Chiu W, Wensel TG. Structures of TRPV2 in distinct conformations provide insight into role of the pore turret. Nat Struct Mol Biol. 2019 Jan; 26(1):40-49. PMID: 30598551.
      View in: PubMed
    7. Michalska K, Zhang K, March ZM, Hatzos-Skintges C, Pintilie G, Bigelow L, Castellano LM, Miles LJ, Jackrel ME, Chuang E, Jedrzejczak R, Shorter J, Chiu W, Joachimiak A. Structure of Calcarisporiella thermophila Hsp104 Disaggregase that Antagonizes Diverse Proteotoxic Misfolding Events. Structure. 2019 Mar 05; 27(3):449-463.e7. PMID: 30595457.
      View in: PubMed
    8. Qi X, Zhang F, Su Z, Jiang S, Han D, Ding B, Liu Y, Chiu W, Yin P, Yan H. Programming molecular topologies from single-stranded nucleic acids. Nat Commun. 2018 11 02; 9(1):4579. PMID: 30389935.
      View in: PubMed
    9. Lawson CL, Chiu W. Comparing cryo-EM structures. J Struct Biol. 2018 Dec; 204(3):523-526. PMID: 30321594.
      View in: PubMed
    10. Kryshtafovych A, Monastyrskyy B, Adams PD, Lawson CL, Chiu W. Distribution of evaluation scores for the models submitted to the second cryo-EM model challenge. Data Brief. 2018 Oct; 20:1629-1638. PMID: 30263915.
      View in: PubMed
    11. Duyvesteyn HME, Kotecha A, Ginn HM, Hecksel CW, Beale EV, de Haas F, Evans G, Zhang P, Chiu W, Stuart DI. Machining protein microcrystals for structure determination by electron diffraction. Proc Natl Acad Sci U S A. 2018 09 18; 115(38):9569-9573. PMID: 30171169.
      View in: PubMed
    12. Jin J, Galaz-Montoya JG, Sherman MB, Sun SY, Goldsmith CS, O'Toole ET, Ackerman L, Carlson LA, Weaver SC, Chiu W, Simmons G. Neutralizing Antibodies Inhibit Chikungunya Virus Budding at the Plasma Membrane. Cell Host Microbe. 2018 09 12; 24(3):417-428.e5. PMID: 30146390.
      View in: PubMed
    13. Pintilie G, Chiu W. Assessment of structural features in Cryo-EM density maps using SSE and side chain Z-scores. J Struct Biol. 2018 Dec; 204(3):564-571. PMID: 30144506.
      View in: PubMed
    14. Dai W, Chen M, Myers C, Ludtke SJ, Pettitt BM, King JA, Schmid MF, Chiu W. Visualizing Individual RuBisCO and Its Assembly into Carboxysomes in Marine Cyanobacteria by Cryo-Electron Tomography. J Mol Biol. 2018 Oct 19; 430(21):4156-4167. PMID: 30138616.
      View in: PubMed
    15. Heymann JB, Marabini R, Kazemi M, Sorzano COS, Holmdahl M, Mendez JH, Stagg SM, Jonic S, Palovcak E, Armache JP, Zhao J, Cheng Y, Pintilie G, Chiu W, Patwardhan A, Carazo JM. The first single particle analysis Map Challenge: A summary of the assessments. J Struct Biol. 2018 Nov; 204(2):291-300. PMID: 30114512.
      View in: PubMed
    16. Kryshtafovych A, Adams PD, Lawson CL, Chiu W. Evaluation system and web infrastructure for the second cryo-EM model challenge. J Struct Biol. 2018 Oct; 204(1):96-108. PMID: 30017700.
      View in: PubMed
    17. Ge Z, Su Z, Simmons CR, Li J, Jiang S, Li W, Yang Y, Liu Y, Chiu W, Fan C, Yan H. Redox Engineering of Cytochrome c using DNA Nanostructure-Based Charged Encapsulation and Spatial Control. ACS Appl Mater Interfaces. 2019 Apr 17; 11(15):13874-13880. PMID: 29939710.
      View in: PubMed
    18. Sun SY, Kaelber JT, Chen M, Dong X, Nematbakhsh Y, Shi J, Dougherty M, Lim CT, Schmid MF, Chiu W, He CY. Flagellum couples cell shape to motility in Trypanosoma brucei. Proc Natl Acad Sci U S A. 2018 06 26; 115(26):E5916-E5925. PMID: 29891682.
      View in: PubMed
    19. Yeung KHT, Chan KCC, Chan PKS, Lam DSY, Sham PCO, Yau YS, Chan WH, Chiu WK, Ng KL, Ng DKK, Chan IMC, Nelson EAS. Influenza vaccine effectiveness in hospitalised Hong Kong children: Feasibility of estimates from routine surveillance data. Vaccine. 2018 06 07; 36(24):3477-3485. PMID: 29739719.
      View in: PubMed
    20. Roh SH, Stam NJ, Hryc CF, Couoh-Cardel S, Pintilie G, Chiu W, Wilkens S. The 3.5-Å CryoEM Structure of Nanodisc-Reconstituted Yeast Vacuolar ATPase Vo Proton Channel. Mol Cell. 2018 03 15; 69(6):993-1004.e3. PMID: 29526695.
      View in: PubMed
    21. Su Z, Wu C, Shi L, Luthra P, Pintilie GD, Johnson B, Porter JR, Ge P, Chen M, Liu G, Frederick TE, Binning JM, Bowman GR, Zhou ZH, Basler CF, Gross ML, Leung DW, Chiu W, Amarasinghe GK. Electron Cryo-microscopy Structure of Ebola Virus Nucleoprotein Reveals a Mechanism for Nucleocapsid-like Assembly. Cell. 2018 02 22; 172(5):966-978.e12. PMID: 29474922.
      View in: PubMed
    22. Zhang K, Keane SC, Su Z, Irobalieva RN, Chen M, Van V, Sciandra CA, Marchant J, Heng X, Schmid MF, Case DA, Ludtke SJ, Summers MF, Chiu W. Structure of the 30 kDa HIV-1 RNA Dimerization Signal by a Hybrid Cryo-EM, NMR, and Molecular Dynamics Approach. Structure. 2018 03 06; 26(3):490-498.e3. PMID: 29398526.
      View in: PubMed
    23. Erasmus JH, Seymour RL, Kaelber JT, Kim DY, Leal G, Sherman MB, Frolov I, Chiu W, Weaver SC, Nasar F. Novel Insect-Specific Eilat Virus-Based Chimeric Vaccine Candidates Provide Durable, Mono- and Multivalent, Single-Dose Protection against Lethal Alphavirus Challenge. J Virol. 2018 02 15; 92(4). PMID: 29187545.
      View in: PubMed
    24. Du D, Wang Z, Chiu W, Luisi BF. Purification of AcrAB-TolC Multidrug Efflux Pump for Cryo-EM Analysis. Methods Mol Biol. 2018; 1700:71-81. PMID: 29177826.
      View in: PubMed
    25. Evans-Lacko S, Aguilar-Gaxiola S, Al-Hamzawi A, Alonso J, Benjet C, Bruffaerts R, Chiu WT, Florescu S, de Girolamo G, Gureje O, Haro JM, He Y, Hu C, Karam EG, Kawakami N, Lee S, Lund C, Kovess-Masfety V, Levinson D, Navarro-Mateu F, Pennell BE, Sampson NA, Scott KM, Tachimori H, Ten Have M, Viana MC, Williams DR, Wojtyniak BJ, Zarkov Z, Kessler RC, Chatterji S, Thornicroft G. Socio-economic variations in the mental health treatment gap for people with anxiety, mood, and substance use disorders: results from the WHO World Mental Health (WMH) surveys. Psychol Med. 2018 07; 48(9):1560-1571. PMID: 29173244.
      View in: PubMed
    26. Lan X, Su Z, Zhou Y, Meyer T, Ke Y, Wang Q, Chiu W, Liu N, Zou S, Yan H, Liu Y. Programmable Supra-Assembly of a DNA Surface Adapter for Tunable Chiral Directional Self-Assembly of Gold Nanorods. Angew Chem Int Ed Engl. 2017 11 13; 56(46):14632-14636. PMID: 28971555.
      View in: PubMed
    27. Chen M, Dai W, Sun SY, Jonasch D, He CY, Schmid MF, Chiu W, Ludtke SJ. Convolutional neural networks for automated annotation of cellular cryo-electron tomograms. Nat Methods. 2017 Oct; 14(10):983-985. PMID: 28846087.
      View in: PubMed
    28. Yi P, Wang Z, Feng Q, Chou CK, Pintilie GD, Shen H, Foulds CE, Fan G, Serysheva I, Ludtke SJ, Schmid MF, Hung MC, Chiu W, O'Malley BW. Structural and Functional Impacts of ER Coactivator Sequential Recruitment. Mol Cell. 2017 Sep 07; 67(5):733-743.e4. PMID: 28844863.
      View in: PubMed
    29. Chiu W, Downing KH. Editorial overview: Cryo Electron Microscopy: Exciting advances in CryoEM Herald a new era in structural biology. Curr Opin Struct Biol. 2017 10; 46:iv-viii. PMID: 28801059.
      View in: PubMed
    30. Wang Q, Irobalieva RN, Chiu W, Schmid MF, Fogg JM, Zechiedrich L, Pettitt BM. Influence of DNA sequence on the structure of minicircles under torsional stress. Nucleic Acids Res. 2017 Jul 27; 45(13):7633-7642. PMID: 28609782.
      View in: PubMed
    31. Kaelber JT, Hryc CF, Chiu W. Electron Cryomicroscopy of Viruses at Near-Atomic Resolutions. Annu Rev Virol. 2017 09 29; 4(1):287-308. PMID: 28715974.
      View in: PubMed
    32. Roh SH, Hryc CF, Jeong HH, Fei X, Jakana J, Lorimer GH, Chiu W. Subunit conformational variation within individual GroEL oligomers resolved by Cryo-EM. Proc Natl Acad Sci U S A. 2017 08 01; 114(31):8259-8264. PMID: 28710336.
      View in: PubMed
    33. Chiu W, Holton J, Langan P, Sauter NK, Schlichting I, Terwilliger T, Martin JL, Read RJ, Wakatsuki S. Responses to `Atomic resolution': a badly abused term in structural biology. Acta Crystallogr D Struct Biol. 2017 04 01; 73(Pt 4):381-383. PMID: 28375150.
      View in: PubMed
    34. Wang Z, Fan G, Hryc CF, Blaza JN, Serysheva II, Schmid MF, Chiu W, Luisi BF, Du D. An allosteric transport mechanism for the AcrAB-TolC multidrug efflux pump. Elife. 2017 03 29; 6. PMID: 28355133.
      View in: PubMed
    35. Murata K, Zhang Q, Gerardo Galaz-Montoya J, Fu C, Coleman ML, Osburne MS, Schmid MF, Sullivan MB, Chisholm SW, Chiu W. Visualizing Adsorption of Cyanophage P-SSP7 onto Marine Prochlorococcus. Sci Rep. 2017 03 10; 7:44176. PMID: 28281671.
      View in: PubMed
    36. Hryc CF, Chen DH, Afonine PV, Jakana J, Wang Z, Haase-Pettingell C, Jiang W, Adams PD, King JA, Schmid MF, Chiu W. Accurate model annotation of a near-atomic resolution cryo-EM map. Proc Natl Acad Sci U S A. 2017 03 21; 114(12):3103-3108. PMID: 28270620.
      View in: PubMed
    37. Luengo I, Darrow MC, Spink MC, Sun Y, Dai W, He CY, Chiu W, Pridmore T, Ashton AW, Duke EMH, Basham M, French AP. SuRVoS: Super-Region Volume Segmentation workbench. J Struct Biol. 2017 04; 198(1):43-53. PMID: 28246039.
      View in: PubMed
    38. Erasmus JH, Auguste AJ, Kaelber JT, Luo H, Rossi SL, Fenton K, Leal G, Kim DY, Chiu W, Wang T, Frolov I, Nasar F, Weaver SC. A chikungunya fever vaccine utilizing an insect-specific virus platform. Nat Med. 2017 Feb; 23(2):192-199. PMID: 27991917.
      View in: PubMed
    39. Chiu WK, Lam WC, Chu NH, Mok CK, Tung WK, Leung FY, Ting SM. Sexual violence cases in a hospital setting in Hong Kong: victims' demographic, event characteristics, and management. Hong Kong Med J. 2016 Dec; 22(6):576-81. PMID: 27779096.
      View in: PubMed
    40. Khisamutdinov EF, Jasinski DL, Li H, Zhang K, Chiu W, Guo P. Fabrication of RNA 3D Nanoprisms for Loading and Protection of Small RNAs and Model Drugs. Adv Mater. 2016 Dec; 28(45):10079-10087. PMID: 27758001.
      View in: PubMed
    41. Shen K, Calamini B, Fauerbach JA, Ma B, Shahmoradian SH, Serrano Lachapel IL, Chiu W, Lo DC, Frydman J. Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract. Elife. 2016 10 18; 5. PMID: 27751235.
      View in: PubMed
    42. Zhao X, Chen XQ, Han E, Hu Y, Paik P, Ding Z, Overman J, Lau AL, Shahmoradian SH, Chiu W, Thompson LM, Wu C, Mobley WC. TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):E5655-64. PMID: 27601642.
      View in: PubMed
    43. Darrow MC, Zhang Y, Cinquin BP, Smith EA, Boudreau R, Rochat RH, Schmid MF, Xia Y, Larabell CA, Chiu W. Visualizing red blood cell sickling and the effects of inhibition of sphingosine kinase 1 using soft X-ray tomography. J Cell Sci. 2016 09 15; 129(18):3511-7. PMID: 27505892.
      View in: PubMed
    44. Li H, Zhang K, Pi F, Guo S, Shlyakhtenko L, Chiu W, Shu D, Guo P. Controllable Self-Assembly of RNA Tetrahedrons with Precise Shape and Size for Cancer Targeting. Adv Mater. 2016 Sep; 28(34):7501-7. PMID: 27322097.
      View in: PubMed
    45. Roh SH, Kasembeli MM, Galaz-Montoya JG, Chiu W, Tweardy DJ. Chaperonin TRiC/CCT Recognizes Fusion Oncoprotein AML1-ETO through Subunit-Specific Interactions. Biophys J. 2016 06 07; 110(11):2377-2385. PMID: 27276256.
      View in: PubMed
    46. Veneziano R, Ratanalert S, Zhang K, Zhang F, Yan H, Chiu W, Bathe M. Designer nanoscale DNA assemblies programmed from the top down. Science. 2016 Jun 24; 352(6293):1534. PMID: 27229143.
      View in: PubMed
    47. Hecksel CW, Darrow MC, Dai W, Galaz-Montoya JG, Chin JA, Mitchell PG, Chen S, Jakana J, Schmid MF, Chiu W. Quantifying Variability of Manual Annotation in Cryo-Electron Tomograms. Microsc Microanal. 2016 06; 22(3):487-96. PMID: 27225525.
      View in: PubMed
    48. Galaz-Montoya JG, Hecksel CW, Baldwin PR, Wang E, Weaver SC, Schmid MF, Ludtke SJ, Chiu W. Alignment algorithms and per-particle CTF correction for single particle cryo-electron tomography. J Struct Biol. 2016 06; 194(3):383-94. PMID: 27016284.
      View in: PubMed
    49. Marabini R, Ludtke SJ, Murray SC, Chiu W, de la Rosa-Trevín JM, Patwardhan A, Heymann JB, Carazo JM. The Electron Microscopy eXchange (EMX) initiative. J Struct Biol. 2016 May; 194(2):156-63. PMID: 26873784.
      View in: PubMed
    50. Pintilie G, Chen DH, Haase-Pettingell CA, King JA, Chiu W. Resolution and Probabilistic Models of Components in CryoEM Maps of Mature P22 Bacteriophage. Biophys J. 2016 Feb 23; 110(4):827-39. PMID: 26743049.
      View in: PubMed
    51. Roh SH, Kasembeli M, Galaz-Montoya JG, Trnka M, Lau WC, Burlingame A, Chiu W, Tweardy DJ. Chaperonin TRiC/CCT Modulates the Folding and Activity of Leukemogenic Fusion Oncoprotein AML1-ETO. J Biol Chem. 2016 Feb 26; 291(9):4732-41. PMID: 26706127.
      View in: PubMed
    52. Lawson CL, Patwardhan A, Baker ML, Hryc C, Garcia ES, Hudson BP, Lagerstedt I, Ludtke SJ, Pintilie G, Sala R, Westbrook JD, Berman HM, Kleywegt GJ, Chiu W. EMDataBank unified data resource for 3DEM. Nucleic Acids Res. 2016 Jan 04; 44(D1):D396-403. PMID: 26578576.
      View in: PubMed
    53. Roh SH, Kasembeli M, Bakthavatsalam D, Chiu W, Tweardy DJ. Contribution of the Type II Chaperonin, TRiC/CCT, to Oncogenesis. Int J Mol Sci. 2015 Nov 06; 16(11):26706-20. PMID: 26561808.
      View in: PubMed
    54. Wang R, Stone RL, Kaelber JT, Rochat RH, Nick AM, Vijayan KV, Afshar-Kharghan V, Schmid MF, Dong JF, Sood AK, Chiu W. Electron cryotomography reveals ultrastructure alterations in platelets from patients with ovarian cancer. Proc Natl Acad Sci U S A. 2015 Nov 17; 112(46):14266-71. PMID: 26578771.
      View in: PubMed
    55. Irobalieva RN, Fogg JM, Catanese DJ, Sutthibutpong T, Chen M, Barker AK, Ludtke SJ, Harris SA, Schmid MF, Chiu W, Zechiedrich L. Erratum: Structural diversity of supercoiled DNA. Nat Commun. 2015 Oct 29; 6:8851. PMID: 26511109.
      View in: PubMed
    56. Fan G, Baker ML, Wang Z, Baker MR, Sinyagovskiy PA, Chiu W, Ludtke SJ, Serysheva II. Gating machinery of InsP3R channels revealed by electron cryomicroscopy. Nature. 2015 Nov 19; 527(7578):336-41. PMID: 26458101.
      View in: PubMed
    57. Irobalieva RN, Fogg JM, Catanese DJ, Catanese DJ, Sutthibutpong T, Chen M, Barker AK, Ludtke SJ, Harris SA, Schmid MF, Chiu W, Zechiedrich L. Structural diversity of supercoiled DNA. Nat Commun. 2015 Oct 12; 6:8440. PMID: 26455586.
      View in: PubMed
    58. Lu J, Trnka MJ, Roh SH, Robinson PJ, Shiau C, Fujimori DG, Chiu W, Burlingame AL, Guan S. Improved Peak Detection and Deconvolution of Native Electrospray Mass Spectra from Large Protein Complexes. J Am Soc Mass Spectrom. 2015 Dec; 26(12):2141-51. PMID: 26323614.
      View in: PubMed
    59. Du D, Voss J, Wang Z, Chiu W, Luisi BF. The pseudo-atomic structure of an RND-type tripartite multidrug efflux pump. Biol Chem. 2015 Sep; 396(9-10):1073-82. PMID: 25803077.
      View in: PubMed
    60. Tan Z, Dai W, van Erp TG, Overman J, Demuro A, Digman MA, Hatami A, Albay R, Sontag EM, Potkin KT, Ling S, Macciardi F, Bunney WE, Long JD, Paulsen JS, Ringman JM, Parker I, Glabe C, Thompson LM, Chiu W, Potkin SG. Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin. Mol Psychiatry. 2015 Nov; 20(11):1286-93. PMID: 26100538.
      View in: PubMed
    61. Sali A, Berman HM, Schwede T, Trewhella J, Kleywegt G, Burley SK, Markley J, Nakamura H, Adams P, Bonvin AM, Chiu W, Peraro MD, Di Maio F, Ferrin TE, Grünewald K, Gutmanas A, Henderson R, Hummer G, Iwasaki K, Johnson G, Lawson CL, Meiler J, Marti-Renom MA, Montelione GT, Nilges M, Nussinov R, Patwardhan A, Rappsilber J, Read RJ, Saibil H, Schröder GF, Schwieters CD, Seidel CA, Svergun D, Topf M, Ulrich EL, Velankar S, Westbrook JD. Outcome of the First wwPDB Hybrid/Integrative Methods Task Force Workshop. Structure. 2015 Jul 07; 23(7):1156-67. PMID: 26095030.
      View in: PubMed
    62. Darrow MC, Sergeeva OA, Isas JM, Galaz-Montoya JG, King JA, Langen R, Schmid MF, Chiu W. Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by the Synthetic Chaperonin-like CCT5 Complex Explained by Cryoelectron Tomography. J Biol Chem. 2015 Jul 10; 290(28):17451-61. PMID: 25995452.
      View in: PubMed
    63. Marabini R, Carragher B, Chen S, Chen J, Cheng A, Downing KH, Frank J, Grassucci RA, Bernard Heymann J, Jiang W, Jonic S, Liao HY, Ludtke SJ, Patwari S, Piotrowski AL, Quintana A, Sorzano CO, Stahlberg H, Vargas J, Voss NR, Chiu W, Carazo JM. CTF Challenge: Result summary. J Struct Biol. 2015 Jun; 190(3):348-59. PMID: 25913484.
      View in: PubMed
    64. Leung DW, Borek D, Luthra P, Binning JM, Anantpadma M, Liu G, Harvey IB, Su Z, Endlich-Frazier A, Pan J, Shabman RS, Chiu W, Davey RA, Otwinowski Z, Basler CF, Amarasinghe GK. An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions. Cell Rep. 2015 Apr 21; 11(3):376-89. PMID: 25865894.
      View in: PubMed
    65. Yi P, Wang Z, Feng Q, Pintilie GD, Foulds CE, Lanz RB, Ludtke SJ, Schmid MF, Chiu W, O'Malley BW. Structure of a biologically active estrogen receptor-coactivator complex on DNA. Mol Cell. 2015 Mar 19; 57(6):1047-1058. PMID: 25728767.
      View in: PubMed
    66. Hong C, Pietilä MK, Fu CJ, Schmid MF, Bamford DH, Chiu W. Lemon-shaped halo archaeal virus His1 with uniform tail but variable capsid structure. Proc Natl Acad Sci U S A. 2015 Feb 24; 112(8):2449-54. PMID: 25675521.
      View in: PubMed
    67. Hong C, Oksanen HM, Liu X, Jakana J, Bamford DH, Chiu W. A structural model of the genome packaging process in a membrane-containing double stranded DNA virus. PLoS Biol. 2014 Dec; 12(12):e1002024. PMID: 25514469.
      View in: PubMed
    68. Dai W, Fu C, Khant HA, Ludtke SJ, Schmid MF, Chiu W. Zernike phase-contrast electron cryotomography applied to marine cyanobacteria infected with cyanophages. Nat Protoc. 2014 Nov; 9(11):2630-42. PMID: 25321408.
      View in: PubMed
    69. Patwardhan A, Ashton A, Brandt R, Butcher S, Carzaniga R, Chiu W, Collinson L, Doux P, Duke E, Ellisman MH, Franken E, Grünewald K, Heriche JK, Koster A, Kühlbrandt W, Lagerstedt I, Larabell C, Lawson CL, Saibil HR, Sanz-García E, Subramaniam S, Verkade P, Swedlow JR, Kleywegt GJ. A 3D cellular context for the macromolecular world. Nat Struct Mol Biol. 2014 Oct; 21(10):841-5. PMID: 25289590.
      View in: PubMed
    70. Afonin KA, Viard M, Koyfman AY, Martins AN, Kasprzak WK, Panigaj M, Desai R, Santhanam A, Grabow WW, Jaeger L, Heldman E, Reiser J, Chiu W, Freed EO, Shapiro BA. Multifunctional RNA nanoparticles. Nano Lett. 2014 Oct 08; 14(10):5662-71. PMID: 25267559.
      View in: PubMed
    71. Wang Z, Hryc CF, Bammes B, Afonine PV, Jakana J, Chen DH, Liu X, Baker ML, Kao C, Ludtke SJ, Schmid MF, Adams PD, Chiu W. An atomic model of brome mosaic virus using direct electron detection and real-space optimization. Nat Commun. 2014 Sep 04; 5:4808. PMID: 25185801.
      View in: PubMed
    72. Gipson P, Baker ML, Raytcheva D, Haase-Pettingell C, Piret J, King JA, Chiu W. Protruding knob-like proteins violate local symmetries in an icosahedral marine virus. Nat Commun. 2014 Jul 02; 5:4278. PMID: 24985522.
      View in: PubMed
    73. Dai W, Schmid MF, King JA, Chiu W. Identifying the assembly pathway of cyanophage inside the marine bacterium using electron cryo-tomography. Microb Cell. 2014 Jun 01; 1(1):45-47. PMID: 25419524.
      View in: PubMed
    74. Kasembeli M, Lau WC, Roh SH, Eckols TK, Frydman J, Chiu W, Tweardy DJ. Modulation of STAT3 folding and function by TRiC/CCT chaperonin. PLoS Biol. 2014 Apr; 12(4):e1001844. PMID: 24756126.
      View in: PubMed
    75. Du D, Wang Z, James NR, Voss JE, Klimont E, Ohene-Agyei T, Venter H, Chiu W, Luisi BF. Structure of the AcrAB-TolC multidrug efflux pump. Nature. 2014 May 22; 509(7501):512-5. PMID: 24747401.
      View in: PubMed
    76. Shahmoradian SH, Galiano MR, Wu C, Chen S, Rasband MN, Mobley WC, Chiu W. Preparation of primary neurons for visualizing neurites in a frozen-hydrated state using cryo-electron tomography. J Vis Exp. 2014 Feb 12; (84):e50783. PMID: 24561719.
      View in: PubMed
    77. Leung TF, Lam DS, Miu TY, Hon KL, Chau CS, Ku SW, Lee RS, Chow PY, Chiu WK, Ng DK. Epidemiology and risk factors for severe respiratory syncytial virus infections requiring pediatric intensive care admission in Hong Kong children. Infection. 2014 Apr; 42(2):343-50. PMID: 24277597.
      View in: PubMed
    78. Hoersch D, Roh SH, Chiu W, Kortemme T. Reprogramming an ATP-driven protein machine into a light-gated nanocage. Nat Nanotechnol. 2013 Dec; 8(12):928-32. PMID: 24270642.
      View in: PubMed
    79. Dai W, Fu C, Raytcheva D, Flanagan J, Khant HA, Liu X, Rochat RH, Haase-Pettingell C, Piret J, Ludtke SJ, Nagayama K, Schmid MF, King JA, Chiu W. Visualizing virus assembly intermediates inside marine cyanobacteria. Nature. 2013 Oct 31; 502(7473):707-10. PMID: 24107993.
      View in: PubMed
    80. Wagner G, Chiu W. Exploring new limits in complex biological structures. Curr Opin Struct Biol. 2013 Oct; 23(5):704-6. PMID: 24076042.
      View in: PubMed
    81. Baker ML, Hryc CF, Zhang Q, Wu W, Jakana J, Haase-Pettingell C, Afonine PV, Adams PD, King JA, Jiang W, Chiu W. Validated near-atomic resolution structure of bacteriophage epsilon15 derived from cryo-EM and modeling. Proc Natl Acad Sci U S A. 2013 Jul 23; 110(30):12301-6. PMID: 23840063.
      View in: PubMed
    82. Shahmoradian SH, Galaz-Montoya JG, Schmid MF, Cong Y, Ma B, Spiess C, Frydman J, Ludtke SJ, Chiu W. TRiC's tricks inhibit huntingtin aggregation. Elife. 2013 Jul 09; 2:e00710. PMID: 23853712.
      View in: PubMed
    83. Chen DH, Madan D, Weaver J, Lin Z, Schröder GF, Chiu W, Rye HS. Visualizing GroEL/ES in the act of encapsulating a folding protein. Cell. 2013 Jun 06; 153(6):1354-65. PMID: 23746846.
      View in: PubMed
    84. DiMaio F, Zhang J, Chiu W, Baker D. Cryo-EM model validation using independent map reconstructions. Protein Sci. 2013 Jun; 22(6):865-8. PMID: 23592445.
      View in: PubMed
    85. Murray SC, Flanagan J, Popova OB, Chiu W, Ludtke SJ, Serysheva II. Validation of cryo-EM structure of IP3R1 channel. Structure. 2013 Jun 04; 21(6):900-9. PMID: 23707684.
      View in: PubMed
    86. Sergeeva OA, Chen B, Haase-Pettingell C, Ludtke SJ, Chiu W, King JA. Human CCT4 and CCT5 chaperonin subunits expressed in Escherichia coli form biologically active homo-oligomers. J Biol Chem. 2013 Jun 14; 288(24):17734-44. PMID: 23612981.
      View in: PubMed
    87. Zhang Q, Dai X, Cong Y, Zhang J, Chen DH, Dougherty MT, Wang J, Ludtke SJ, Schmid MF, Chiu W. Cryo-EM structure of a molluscan hemocyanin suggests its allosteric mechanism. Structure. 2013 Apr 02; 21(4):604-13. PMID: 23541894.
      View in: PubMed
    88. Rees I, Langley E, Chiu W, Ludtke SJ. EMEN2: an object oriented database and electronic lab notebook. Microsc Microanal. 2013 Feb; 19(1):1-10. PMID: 23360752.
      View in: PubMed
    89. Gilliam JC, Chang JT, Sandoval IM, Zhang Y, Li T, Pittler SJ, Chiu W, Wensel TG. Three-dimensional architecture of the rod sensory cilium and its disruption in retinal neurodegeneration. Cell. 2012 Nov 21; 151(5):1029-41. PMID: 23178122.
      View in: PubMed
    90. Pintilie G, Chiu W. Comparison of Segger and other methods for segmentation and rigid-body docking of molecular components in cryo-EM density maps. Biopolymers. 2012 Sep; 97(9):742-60. PMID: 22696409.
      View in: PubMed
    91. Baker ML, Baker MR, Hryc CF, Ju T, Chiu W. Gorgon and pathwalking: macromolecular modeling tools for subnanometer resolution density maps. Biopolymers. 2012 Sep; 97(9):655-68. PMID: 22696403.
      View in: PubMed
    92. Ludtke SJ, Lawson CL, Kleywegt GJ, Berman H, Chiu W. The 2010 cryo-EM modeling challenge. Biopolymers. 2012 Sep; 97(9):651-4. PMID: 22696402.
      View in: PubMed
    93. Leitner A, Joachimiak LA, Bracher A, Mönkemeyer L, Walzthoeni T, Chen B, Pechmann S, Holmes S, Cong Y, Ma B, Ludtke S, Chiu W, Hartl FU, Aebersold R, Frydman J. The molecular architecture of the eukaryotic chaperonin TRiC/CCT. Structure. 2012 May 09; 20(5):814-25. PMID: 22503819.
      View in: PubMed
    94. Yu CC, Li AM, Au CT, McManus AM, So RC, Lam HS, Chu WC, So HK, Chiu WK, Leung CW, Yau YS, Fok TF, Sung RY. Follow up of aerobic capacity in children affected by severe acute respiratory syndrome. Respirology. 2012 Apr; 17(3):513-8. PMID: 22212464.
      View in: PubMed
    95. Ni P, Wang Z, Ma X, Das NC, Sokol P, Chiu W, Dragnea B, Hagan M, Kao CC. An examination of the electrostatic interactions between the N-terminal tail of the Brome Mosaic Virus coat protein and encapsidated RNAs. J Mol Biol. 2012 Jun 22; 419(5):284-300. PMID: 22472420.
      View in: PubMed
    96. Baker MR, Rees I, Ludtke SJ, Chiu W, Baker ML. Constructing and validating initial Ca models from subnanometer resolution density maps with pathwalking. Structure. 2012 Mar 07; 20(3):450-63. PMID: 22405004.
      View in: PubMed
    97. Fauerbach JA, Yushchenko DA, Shahmoradian SH, Chiu W, Jovin TM, Jares-Erijman EA. Supramolecular non-amyloid intermediates in the early stages of a-synuclein aggregation. Biophys J. 2012 Mar 07; 102(5):1127-36. PMID: 22404935.
      View in: PubMed
    98. Stone RL, Nick AM, McNeish IA, Balkwill F, Han HD, Bottsford-Miller J, Rupairmoole R, Armaiz-Pena GN, Pecot CV, Coward J, Deavers MT, Vasquez HG, Urbauer D, Landen CN, Hu W, Gershenson H, Matsuo K, Shahzad MM, King ER, Tekedereli I, Ozpolat B, Ahn EH, Bond VK, Wang R, Drew AF, Gushiken F, Lamkin D, Collins K, DeGeest K, Lutgendorf SK, Chiu W, Lopez-Berestein G, Afshar-Kharghan V, Sood AK. Paraneoplastic thrombocytosis in ovarian cancer. N Engl J Med. 2012 Feb 16; 366(7):610-8. PMID: 22335738.
      View in: PubMed
    99. Henderson R, Sali A, Baker ML, Carragher B, Devkota B, Downing KH, Egelman EH, Feng Z, Frank J, Grigorieff N, Jiang W, Ludtke SJ, Medalia O, Penczek PA, Rosenthal PB, Rossmann MG, Schmid MF, Schröder GF, Steven AC, Stokes DL, Westbrook JD, Wriggers W, Yang H, Young J, Berman HM, Chiu W, Kleywegt GJ, Lawson CL. Outcome of the first electron microscopy validation task force meeting. Structure. 2012 Feb 08; 20(2):205-14. PMID: 22325770.
      View in: PubMed
    100. Bammes BE, Rochat RH, Jakana J, Chen DH, Chiu W. Direct electron detection yields cryo-EM reconstructions at resolutions beyond 3/4 Nyquist frequency. J Struct Biol. 2012 Mar; 177(3):589-601. PMID: 22285189.
      View in: PubMed
    101. Chang J, Liu X, Rochat RH, Baker ML, Chiu W. Reconstructing virus structures from nanometer to near-atomic resolutions with cryo-electron microscopy and tomography. Adv Exp Med Biol. 2012; 726:49-90. PMID: 22297510.
      View in: PubMed
    102. Kim TH, Mount CW, Dulken BW, Ramos J, Fu CJ, Khant HA, Chiu W, Gombotz WR, Pun SH. Filamentous, mixed micelles of triblock copolymers enhance tumor localization of indocyanine green in a murine xenograft model. Mol Pharm. 2012 Jan 01; 9(1):135-43. PMID: 22118658.
      View in: PubMed
    103. Cong Y, Schröder GF, Meyer AS, Jakana J, Ma B, Dougherty MT, Schmid MF, Reissmann S, Levitt M, Ludtke SL, Frydman J, Chiu W. Symmetry-free cryo-EM structures of the chaperonin TRiC along its ATPase-driven conformational cycle. EMBO J. 2012 Feb 01; 31(3):720-30. PMID: 22045336.
      View in: PubMed
    104. Ludtke SJ, Tran TP, Ngo QT, Moiseenkova-Bell VY, Chiu W, Serysheva II. Flexible architecture of IP3R1 by Cryo-EM. Structure. 2011 Aug 10; 19(8):1192-9. PMID: 21827954.
      View in: PubMed
    105. Zhang R, Hryc CF, Cong Y, Liu X, Jakana J, Gorchakov R, Baker ML, Weaver SC, Chiu W. 4.4 Å cryo-EM structure of an enveloped alphavirus Venezuelan equine encephalitis virus. EMBO J. 2011 Aug 09; 30(18):3854-63. PMID: 21829169.
      View in: PubMed
    106. Hryc CF, Chen DH, Chiu W. Near-atomic-resolution cryo-EM for molecular virology. Curr Opin Virol. 2011 Aug; 1(2):110-7. PMID: 21845206.
      View in: PubMed
    107. Kostyuchenko VA, Jakana J, Liu X, Haddow AD, Aung M, Weaver SC, Chiu W, Lok SM. The structure of barmah forest virus as revealed by cryo-electron microscopy at a 6-angstrom resolution has detailed transmembrane protein architecture and interactions. J Virol. 2011 Sep; 85(18):9327-33. PMID: 21752915.
      View in: PubMed
    108. Koyfman AY, Schmid MF, Gheiratmand L, Fu CJ, Khant HA, Huang D, He CY, Chiu W. Structure of Trypanosoma brucei flagellum accounts for its bihelical motion. Proc Natl Acad Sci U S A. 2011 Jul 05; 108(27):11105-8. PMID: 21690369.
      View in: PubMed
    109. Ng DK, Miu TY, Chiu WK, Hui NT, Chan CH. Validation of Pediatric Index of Mortality 2 in three pediatric intensive care units in Hong Kong. Indian J Pediatr. 2011 Dec; 78(12):1491-4. PMID: 21617907.
      View in: PubMed
    110. Bammes BE, Rochat RH, Jakana J, Chiu W. Practical performance evaluation of a 10k × 10k CCD for electron cryo-microscopy. J Struct Biol. 2011 Sep; 175(3):384-93. PMID: 21619932.
      View in: PubMed
    111. Zhang J, Ma B, DiMaio F, Douglas NR, Joachimiak LA, Baker D, Frydman J, Levitt M, Chiu W. Cryo-EM structure of a group II chaperonin in the prehydrolysis ATP-bound state leading to lid closure. Structure. 2011 May 11; 19(5):633-9. PMID: 21565698.
      View in: PubMed
    112. Lee LP, Chiu WK, Chan HB, Liu KK. Minimally invasive chest drain insertion in children. Hong Kong Med J. 2011 Apr; 17(2):137-40. PMID: 21471594.
      View in: PubMed
    113. Qin G, Li Z, Xia R, Li F, O'Neill BE, Goodwin JT, Khant HA, Chiu W, Li KC. Partially polymerized liposomes: stable against leakage yet capable of instantaneous release for remote controlled drug delivery. Nanotechnology. 2011 Apr 15; 22(15):155605. PMID: 21389566.
      View in: PubMed
    114. Moon JJ, Suh H, Bershteyn A, Stephan MT, Liu H, Huang B, Sohail M, Luo S, Um SH, Khant H, Goodwin JT, Ramos J, Chiu W, Irvine DJ. Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses. Nat Mater. 2011 Mar; 10(3):243-51. PMID: 21336265.
      View in: PubMed
    115. Baker ML, Abeysinghe SS, Schuh S, Coleman RA, Abrams A, Marsh MP, Hryc CF, Ruths T, Chiu W, Ju T. Modeling protein structure at near atomic resolutions with Gorgon. J Struct Biol. 2011 May; 174(2):360-73. PMID: 21296162.
      View in: PubMed
    116. Douglas NR, Reissmann S, Zhang J, Chen B, Jakana J, Kumar R, Chiu W, Frydman J. Dual action of ATP hydrolysis couples lid closure to substrate release into the group II chaperonin chamber. Cell. 2011 Jan 21; 144(2):240-52. PMID: 21241893.
      View in: PubMed
    117. Chen DH, Baker ML, Hryc CF, DiMaio F, Jakana J, Wu W, Dougherty M, Haase-Pettingell C, Schmid MF, Jiang W, Baker D, King JA, Chiu W. Structural basis for scaffolding-mediated assembly and maturation of a dsDNA virus. Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4):1355-60. PMID: 21220301.
      View in: PubMed
    118. Knee KM, Goulet DR, Zhang J, Chen B, Chiu W, King JA. The group II chaperonin Mm-Cpn binds and refolds human ?D crystallin. Protein Sci. 2011 Jan; 20(1):30-41. PMID: 20981710.
      View in: PubMed
    119. Ludtke SJ, Lawson CL, Kleywegt GJ, Berman HM, Chiu W. Workshop on the validation and modeling of electron cryo-microscopy structures of biological nanomachines. Pac Symp Biocomput. 2011; 369-73. PMID: 21121065.
      View in: PubMed
    120. Rochat RH, Liu X, Murata K, Nagayama K, Rixon FJ, Chiu W. Seeing the portal in herpes simplex virus type 1 B capsids. J Virol. 2011 Feb; 85(4):1871-4. PMID: 21106752.
      View in: PubMed
    121. Baird NJ, Ludtke SJ, Khant H, Chiu W, Pan T, Sosnick TR. Discrete structure of an RNA folding intermediate revealed by cryo-electron microscopy. J Am Chem Soc. 2010 Nov 24; 132(46):16352-3. PMID: 21038867.
      View in: PubMed
    122. Bromberg S, Chiu W, Ferrin TE. Workshop on molecular animation. Structure. 2010 Oct 13; 18(10):1261-5. PMID: 20947014.
      View in: PubMed
    123. Lawson CL, Baker ML, Best C, Bi C, Dougherty M, Feng P, van Ginkel G, Devkota B, Lagerstedt I, Ludtke SJ, Newman RH, Oldfield TJ, Rees I, Sahni G, Sala R, Velankar S, Warren J, Westbrook JD, Henrick K, Kleywegt GJ, Berman HM, Chiu W. EMDataBank.org: unified data resource for CryoEM. Nucleic Acids Res. 2011 Jan; 39(Database issue):D456-64. PMID: 20935055.
      View in: PubMed
    124. Miyazaki Y, Irobalieva RN, Tolbert BS, Smalls-Mantey A, Iyalla K, Loeliger K, D'Souza V, Khant H, Schmid MF, Garcia EL, Telesnitsky A, Chiu W, Summers MF. Structure of a conserved retroviral RNA packaging element by NMR spectroscopy and cryo-electron tomography. J Mol Biol. 2010 Dec 17; 404(5):751-72. PMID: 20933521.
      View in: PubMed
    125. Baker ML, Zhang J, Ludtke SJ, Chiu W. Cryo-EM of macromolecular assemblies at near-atomic resolution. Nat Protoc. 2010 Sep; 5(10):1697-708. PMID: 20885381.
      View in: PubMed
    126. Chang JT, Schmid MF, Haase-Pettingell C, Weigele PR, King JA, Chiu W. Visualizing the structural changes of bacteriophage Epsilon15 and its Salmonella host during infection. J Mol Biol. 2010 Oct 01; 402(4):731-40. PMID: 20709082.
      View in: PubMed
    127. Murata K, Liu X, Danev R, Jakana J, Schmid MF, King J, Nagayama K, Chiu W. Zernike phase contrast cryo-electron microscopy and tomography for structure determination at nanometer and subnanometer resolutions. Structure. 2010 Aug 11; 18(8):903-12. PMID: 20696391.
      View in: PubMed
    128. Chu TB, Liao CW, D'Lamini P, Chang PW, Chiu WT, Du WY, Fan CK. Prevalence of Schistosoma haematobium infection among inhabitants of Lowveld, Swaziland, an endemic area for the disease. Trop Biomed. 2010 Aug; 27(2):337-42. PMID: 20962734.
      View in: PubMed
    129. Saha M, Levitt M, Chiu W. MOTIF-EM: an automated computational tool for identifying conserved regions in CryoEM structures. Bioinformatics. 2010 Jun 15; 26(12):i301-9. PMID: 20529921.
      View in: PubMed
    130. Liu X, Zhang Q, Murata K, Baker ML, Sullivan MB, Fu C, Dougherty MT, Schmid MF, Osburne MS, Chisholm SW, Chiu W. Structural changes in a marine podovirus associated with release of its genome into Prochlorococcus. Nat Struct Mol Biol. 2010 Jul; 17(7):830-6. PMID: 20543830.
      View in: PubMed
    131. Haspel N, Moll M, Baker ML, Chiu W, Kavraki LE. Tracing conformational changes in proteins. BMC Struct Biol. 2010 May 17; 10 Suppl 1:S1. PMID: 20487508.
      View in: PubMed
    132. Lee LP, Lai MH, Chiu WK, Leung MW, Liu KK, Chan HB. Management of primary spontaneous pneumothorax in Chinese children. Hong Kong Med J. 2010 Apr; 16(2):94-100. PMID: 20354242.
      View in: PubMed
    133. Nakamura N, Shimizu Y, Shinkawa T, Nakata M, Bammes B, Zhang J, Chiu W. Automated specimen search in cryo-TEM observation with DIFF-defocus imaging. J Electron Microsc (Tokyo). 2010; 59(4):299-310. PMID: 20356853.
      View in: PubMed
    134. Pintilie GD, Zhang J, Goddard TD, Chiu W, Gossard DC. Quantitative analysis of cryo-EM density map segmentation by watershed and scale-space filtering, and fitting of structures by alignment to regions. J Struct Biol. 2010 Jun; 170(3):427-38. PMID: 20338243.
      View in: PubMed
    135. Cong Y, Baker ML, Jakana J, Woolford D, Miller EJ, Reissmann S, Kumar RN, Redding-Johanson AM, Batth TS, Mukhopadhyay A, Ludtke SJ, Frydman J, Chiu W. 4.0-A resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):4967-72. PMID: 20194787.
      View in: PubMed
    136. Zhang J, Baker ML, Schröder GF, Douglas NR, Reissmann S, Jakana J, Dougherty M, Fu CJ, Levitt M, Ludtke SJ, Frydman J, Chiu W. Mechanism of folding chamber closure in a group II chaperonin. Nature. 2010 Jan 21; 463(7279):379-83. PMID: 20090755.
      View in: PubMed
    137. Sherman MB, Freiberg AN, Razmus D, Yazuka S, Koht C, Hilser VJ, Lemon SM, Brocard AS, Zimmerman D, Chiu W, Watowich SJ, Weaver SC. A Unique BSL-3 Cryo-Electron Microscopy Laboratory at UTMB. Appl Biosaf. 2010; 15(3):130-136. PMID: 21852942.
      View in: PubMed
    138. Ren G, Rudenko G, Ludtke SJ, Deisenhofer J, Chiu W, Pownall HJ. Model of human low-density lipoprotein and bound receptor based on cryoEM. Proc Natl Acad Sci U S A. 2010 Jan 19; 107(3):1059-64. PMID: 20080547.
      View in: PubMed
    139. Liao CW, Lee YL, Sukati H, D'lamini P, Huang YC, Chiu CJ, Liu YH, Chou CM, Chiu WT, Du WY, Hung CC, Chan HC, Chu B, Cheng HC, Su J, Tu CC, Cheng CY, Fan CK. Seroprevalence of Toxoplasma gondii infection among children in Swaziland, southern Africa. Ann Trop Med Parasitol. 2009 Dec; 103(8):731-6. PMID: 20030998.
      View in: PubMed
    140. Bammes BE, Jakana J, Schmid MF, Chiu W. Radiation damage effects at four specimen temperatures from 4 to 100 K. J Struct Biol. 2010 Mar; 169(3):331-41. PMID: 19903530.
      View in: PubMed
    141. Carson J, Ju T, Bello M, Thaller C, Warren J, Kakadiaris IA, Chiu W, Eichele G. Automated pipeline for atlas-based annotation of gene expression patterns: application to postnatal day 7 mouse brain. Methods. 2010 Feb; 50(2):85-95. PMID: 19698790.
      View in: PubMed
    142. DiMaio F, Tyka MD, Baker ML, Chiu W, Baker D. Refinement of protein structures into low-resolution density maps using rosetta. J Mol Biol. 2009 Sep 11; 392(1):181-90. PMID: 19596339.
      View in: PubMed
    143. Cong Y, Zhang Q, Woolford D, Schweikardt T, Khant H, Dougherty M, Ludtke SJ, Chiu W, Decker H. Structural mechanism of SDS-induced enzyme activity of scorpion hemocyanin revealed by electron cryomicroscopy. Structure. 2009 May 13; 17(5):749-58. PMID: 19446530.
      View in: PubMed
    144. Pintilie G, Zhang J, Chiu W, Gossard D. Identifying Components in 3D Density Maps of Protein Nanomachines by Multi-scale Segmentation. IEEE NIH Life Sci Syst Appl Workshop. 2009 Apr 01; 2009:44-47. PMID: 20556220.
      View in: PubMed
    145. Zhang R, Hu X, Khant H, Ludtke SJ, Chiu W, Schmid MF, Frieden C, Lee JM. Interprotofilament interactions between Alzheimer's Abeta1-42 peptides in amyloid fibrils revealed by cryoEM. Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4653-8. PMID: 19264960.
      View in: PubMed
    146. Zhang J, Nakamura N, Shimizu Y, Liang N, Liu X, Jakana J, Marsh MP, Booth CR, Shinkawa T, Nakata M, Chiu W. JADAS: a customizable automated data acquisition system and its application to ice-embedded single particles. J Struct Biol. 2009 Jan; 165(1):1-9. PMID: 18926912.
      View in: PubMed
    147. Serysheva II, Ludtke SJ, Baker ML, Cong Y, Topf M, Eramian D, Sali A, Hamilton SL, Chiu W. Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel. Proc Natl Acad Sci U S A. 2008 Jul 15; 105(28):9610-5. PMID: 18621707.
      View in: PubMed
    148. Chen DH, Luke K, Zhang J, Chiu W, Wittung-Stafshede P. Location and flexibility of the unique C-terminal tail of Aquifex aeolicus co-chaperonin protein 10 as derived by cryo-electron microscopy and biophysical techniques. J Mol Biol. 2008 Sep 05; 381(3):707-17. PMID: 18588898.
      View in: PubMed
    149. Wu G, Mikhailovsky A, Khant HA, Fu C, Chiu W, Zasadzinski JA. Remotely triggered liposome release by near-infrared light absorption via hollow gold nanoshells. J Am Chem Soc. 2008 Jul 02; 130(26):8175-7. PMID: 18543914.
      View in: PubMed
    150. Booth CR, Meyer AS, Cong Y, Topf M, Sali A, Ludtke SJ, Chiu W, Frydman J. Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT. Nat Struct Mol Biol. 2008 Jul; 15(7):746-53. PMID: 18536725.
      View in: PubMed
    151. Chen DH, Jakana J, Liu X, Schmid MF, Chiu W. Achievable resolution from images of biological specimens acquired from a 4k x 4k CCD camera in a 300-kV electron cryomicroscope. J Struct Biol. 2008 Jul; 163(1):45-52. PMID: 18514542.
      View in: PubMed
    152. MacLean HE, Chiu WS, Notini AJ, Axell AM, Davey RA, McManus JF, Ma C, Plant DR, Lynch GS, Zajac JD. Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice. FASEB J. 2008 Aug; 22(8):2676-89. PMID: 18390925.
      View in: PubMed
    153. Ludtke SJ, Baker ML, Chen DH, Song JL, Chuang DT, Chiu W. De novo backbone trace of GroEL from single particle electron cryomicroscopy. Structure. 2008 Mar; 16(3):441-8. PMID: 18334219.
      View in: PubMed
    154. Jiang W, Baker ML, Jakana J, Weigele PR, King J, Chiu W. Backbone structure of the infectious epsilon15 virus capsid revealed by electron cryomicroscopy. Nature. 2008 Feb 28; 451(7182):1130-4. PMID: 18305544.
      View in: PubMed
    155. Topf M, Lasker K, Webb B, Wolfson H, Chiu W, Sali A. Protein structure fitting and refinement guided by cryo-EM density. Structure. 2008 Feb; 16(2):295-307. PMID: 18275820.
      View in: PubMed
    156. Chen CY, Ying SH, Yao MS, Chiu WT, Chan WP. Sphenoid sinus osteoma at the sella turcica associated with empty sella: CT and MR imaging findings. AJNR Am J Neuroradiol. 2008 Mar; 29(3):550-1. PMID: 18184833.
      View in: PubMed
    157. Ju DT, Lin JW, Lin MS, Lee LM, Tseng HM, Wei CP, Yen CH, Hung CC, Hung KS, Lin CM, Lin TJ, Chiu WT, Tsai JT. Hypofractionated CyberKnife stereotactic radiosurgery for acoustic neuromas with and without association to neurofibromatosis Type 2. Acta Neurochir Suppl. 2008; 101:169-73. PMID: 18642654.
      View in: PubMed
    158. LaPorte RE, Chiu WT. Strategic plan: building a international strategy for risk reduction supercourse. Acta Neurochir Suppl. 2008; 101:79-81. PMID: 18642638.
      View in: PubMed
    159. Lin JW, Tsai JT, Lin CM, Lee LM, Hung KS, Huang SJ, Hsiao SH, Chung WY, Tsai MD, Hsia CC, Hung CC, Chiu WT. Evaluation of optimal cerebral perfusion pressure in severe traumatic brain injury. Acta Neurochir Suppl. 2008; 101:131-6. PMID: 18642647.
      View in: PubMed
    160. Lin JW, Lin CM, Tsai JT, Hung KS, Hung CC, Chiu WT. Neurotrauma research in Taiwan. Acta Neurochir Suppl. 2008; 101:113-7. PMID: 18642644.
      View in: PubMed
    161. Lin JW, Tsai JT, Lee LM, Lin CM, Hung CC, Hung KS, Chen WY, Wei L, Ko CP, Su YK, Chiu WT. Effect of hyperbaric oxygen on patients with traumatic brain injury. Acta Neurochir Suppl. 2008; 101:145-9. PMID: 18642650.
      View in: PubMed
    162. Lin CM, Lin JW, Tsai JT, Ko CP, Hung KS, Hung CC, Su YK, Wei L, Chiu WT, Lee LM. Intracranial pressure fluctuation during hemodialysis in renal failure patients with intracranial hemorrhage. Acta Neurochir Suppl. 2008; 101:141-4. PMID: 18642649.
      View in: PubMed
    163. Marsh MP, Chang JT, Booth CR, Liang NL, Schmid MF, Chiu W. Modular software platform for low-dose electron microscopy and tomography. J Microsc. 2007 Dec; 228(Pt 3):384-9. PMID: 18045333.
      View in: PubMed
    164. Chiu W, Moffat K. Biophysical methods: structure, dynamics and gorgeous images. Curr Opin Struct Biol. 2007 Oct; 17(5):546-8. PMID: 17959374.
      View in: PubMed
    165. Cong Y, Topf M, Sali A, Matsudaira P, Dougherty M, Chiu W, Schmid MF. Crystallographic conformers of actin in a biologically active bundle of filaments. J Mol Biol. 2008 Jan 11; 375(2):331-6. PMID: 18022194.
      View in: PubMed
    166. Liu X, Jiang W, Jakana J, Chiu W. Averaging tens to hundreds of icosahedral particle images to resolve protein secondary structure elements using a Multi-Path Simulated Annealing optimization algorithm. J Struct Biol. 2007 Oct; 160(1):11-27. PMID: 17698370.
      View in: PubMed
    167. Bello M, Ju T, Carson J, Warren J, Chiu W, Kakadiaris IA. Learning-based segmentation framework for tissue images containing gene expression data. IEEE Trans Med Imaging. 2007 May; 26(5):728-44. PMID: 17518066.
      View in: PubMed
    168. Ju T, Baker ML, Chiu W. Computing a family of skeletons of volumetric models for shape description. Comput Aided Des. 2007 May; 39(5):352-360. PMID: 18449328.
      View in: PubMed
    169. Reissmann S, Parnot C, Booth CR, Chiu W, Frydman J. Essential function of the built-in lid in the allosteric regulation of eukaryotic and archaeal chaperonins. Nat Struct Mol Biol. 2007 May; 14(5):432-40. PMID: 17460696.
      View in: PubMed
    170. Johnson JE, Chiu W. DNA packaging and delivery machines in tailed bacteriophages. Curr Opin Struct Biol. 2007 Apr; 17(2):237-43. PMID: 17395453.
      View in: PubMed
    171. Pope WH, Weigele PR, Chang J, Pedulla ML, Ford ME, Houtz JM, Jiang W, Chiu W, Hatfull GF, Hendrix RW, King J. Genome sequence, structural proteins, and capsid organization of the cyanophage Syn5: a "horned" bacteriophage of marine synechococcus. J Mol Biol. 2007 May 11; 368(4):966-81. PMID: 17383677.
      View in: PubMed
    172. Baker ML, Ju T, Chiu W. Identification of secondary structure elements in intermediate-resolution density maps. Structure. 2007 Jan; 15(1):7-19. PMID: 17223528.
      View in: PubMed
    173. Jiang W, Chiu W. Cryoelectron microscopy of icosahedral virus particles. Methods Mol Biol. 2007; 369:345-63. PMID: 17656759.
      View in: PubMed
    174. Serysheva II, Chiu W, Ludtke SJ. Single-particle electron cryomicroscopy of the ion channels in the excitation-contraction coupling junction. Methods Cell Biol. 2007; 79:407-35. PMID: 17327167.
      View in: PubMed
    175. Chang JT, Schmid MF, Rixon FJ, Chiu W. Electron cryotomography reveals the portal in the herpesvirus capsid. J Virol. 2007 Feb; 81(4):2065-8. PMID: 17151101.
      View in: PubMed
    176. Chen DH, Song JL, Chuang DT, Chiu W, Ludtke SJ. An expanded conformation of single-ring GroEL-GroES complex encapsulates an 86 kDa substrate. Structure. 2006 Nov; 14(11):1711-22. PMID: 17098196.
      View in: PubMed
    177. Baker ML, Jiang W, Wedemeyer WJ, Rixon FJ, Baker D, Chiu W. Ab initio modeling of the herpesvirus VP26 core domain assessed by CryoEM density. PLoS Comput Biol. 2006 Oct 27; 2(10):e146. PMID: 17069457.
      View in: PubMed
    178. Booth CR, Jakana J, Chiu W. Assessing the capabilities of a 4kx4k CCD camera for electron cryo-microscopy at 300kV. J Struct Biol. 2006 Dec; 156(3):556-63. PMID: 17067819.
      View in: PubMed
    179. Marsh MP, Campos SK, Baker ML, Chen CY, Chiu W, Barry MA. Cryoelectron microscopy of protein IX-modified adenoviruses suggests a new position for the C terminus of protein IX. J Virol. 2006 Dec; 80(23):11881-6. PMID: 16987967.
      View in: PubMed
    180. Schmid MF, Paredes AM, Khant HA, Soyer F, Aldrich HC, Chiu W, Shively JM. Structure of Halothiobacillus neapolitanus carboxysomes by cryo-electron tomography. J Mol Biol. 2006 Dec 01; 364(3):526-35. PMID: 17028023.
      View in: PubMed
    181. Chen CY, Chuang YL, Yao MS, Chiu WT, Chen CL, Chan WP. Posterior epidural migration of a sequestrated lumbar disk fragment: MR imaging findings. AJNR Am J Neuroradiol. 2006 Aug; 27(7):1592-4. PMID: 16908587.
      View in: PubMed
    182. Berman HM, Burley SK, Chiu W, Sali A, Adzhubei A, Bourne PE, Bryant SH, Dunbrack RL, Fidelis K, Frank J, Godzik A, Henrick K, Joachimiak A, Heymann B, Jones D, Markley JL, Moult J, Montelione GT, Orengo C, Rossmann MG, Rost B, Saibil H, Schwede T, Standley DM, Westbrook JD. Outcome of a workshop on archiving structural models of biological macromolecules. Structure. 2006 Aug; 14(8):1211-7. PMID: 16955948.
      View in: PubMed
    183. Baker ML, Yu Z, Chiu W, Bajaj C. Automated segmentation of molecular subunits in electron cryomicroscopy density maps. J Struct Biol. 2006 Dec; 156(3):432-41. PMID: 16908194.
      View in: PubMed
    184. Chang J, Weigele P, King J, Chiu W, Jiang W. Cryo-EM asymmetric reconstruction of bacteriophage P22 reveals organization of its DNA packaging and infecting machinery. Structure. 2006 Jun; 14(6):1073-82. PMID: 16730179.
      View in: PubMed
    185. Chiang MF, Chiu WT, Lin FJ, Thajeb P, Huang CJ, Tsai SH. Multiparametric analysis of cerebral substrates and nitric oxide delivery in cerebrospinal fluid in patients with intracerebral haemorrhage: correlation with hemodynamics and outcome. Acta Neurochir (Wien). 2006 Jun; 148(6):615-21; dicussion 621. PMID: 16614805.
      View in: PubMed
    186. Ju T, Warren J, Carson J, Bello M, Kakadiaris I, Chiu W, Thaller C, Eichele G. 3D volume reconstruction of a mouse brain from histological sections using warp filtering. J Neurosci Methods. 2006 Sep 30; 156(1-2):84-100. PMID: 16580732.
      View in: PubMed
    187. Araç D, Chen X, Khant HA, Ubach J, Ludtke SJ, Kikkawa M, Johnson AE, Chiu W, Südhof TC, Rizo J. Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids. Nat Struct Mol Biol. 2006 Mar; 13(3):209-17. PMID: 16491093.
      View in: PubMed
    188. Topf M, Baker ML, Marti-Renom MA, Chiu W, Sali A. Refinement of protein structures by iterative comparative modeling and CryoEM density fitting. J Mol Biol. 2006 Apr 14; 357(5):1655-68. PMID: 16490207.
      View in: PubMed
    189. Jiang W, Chang J, Jakana J, Weigele P, King J, Chiu W. Structure of epsilon15 bacteriophage reveals genome organization and DNA packaging/injection apparatus. Nature. 2006 Feb 02; 439(7076):612-6. PMID: 16452981.
      View in: PubMed
    190. Yu CC, Li AM, So RC, McManus A, Ng PC, Chu W, Chan D, Cheng F, Chiu WK, Leung CW, Yau YS, Mo KW, Wong EM, Cheung AY, Leung TF, Sung RY, Fok TF. Longer term follow up of aerobic capacity in children affected by severe acute respiratory syndrome (SARS). Thorax. 2006 Mar; 61(3):240-6. PMID: 16449271.
      View in: PubMed
    191. Lin JW, Lin MS, Lin CM, Tseng CH, Tsai SH, Kan IH, Chiu WT. Idiopathic syringomyelia: case report and review of the literature. Acta Neurochir Suppl. 2006; 99:117-20. PMID: 17370776.
      View in: PubMed
    192. Passmore LA, Booth CR, Vénien-Bryan C, Ludtke SJ, Fioretto C, Johnson LN, Chiu W, Barford D. Structural analysis of the anaphase-promoting complex reveals multiple active sites and insights into polyubiquitylation. Mol Cell. 2005 Dec 22; 20(6):855-66. PMID: 16364911.
      View in: PubMed
    193. Baker ML, Jiang W, Rixon FJ, Chiu W. Common ancestry of herpesviruses and tailed DNA bacteriophages. J Virol. 2005 Dec; 79(23):14967-70. PMID: 16282496.
      View in: PubMed
    194. Ng YM, Sung RY, So LY, Fong NC, Ho MH, Cheng YW, Lee SH, Mak WC, Wong DM, Yam MC, Kwok KL, Chiu WK. Kawasaki disease in Hong Kong, 1994 to 2000. Hong Kong Med J. 2005 Oct; 11(5):331-5. PMID: 16219951.
      View in: PubMed
    195. Cong Y, Jiang W, Birmanns S, Zhou ZH, Chiu W, Wriggers W. Fast rotational matching of single-particle images. J Struct Biol. 2005 Nov; 152(2):104-12. PMID: 16236526.
      View in: PubMed
    196. Carson JP, Ju T, Lu HC, Thaller C, Xu M, Pallas SL, Crair MC, Warren J, Chiu W, Eichele G. A digital atlas to characterize the mouse brain transcriptome. PLoS Comput Biol. 2005 Sep; 1(4):e41. PMID: 16184189.
      View in: PubMed
    197. Ludtke SJ, Serysheva II, Hamilton SL, Chiu W. The pore structure of the closed RyR1 channel. Structure. 2005 Aug; 13(8):1203-11. PMID: 16084392.
      View in: PubMed
    198. Tsai JC, Chang WY, Hsueh IH, Yang MC, Chiu WT, Huang WS, Huang SS. In-patient medical resource utilization for high-level cervical spinal cord injury without bone fracture in Taiwan. Spinal Cord. 2005 Jul; 43(7):426-33. PMID: 15753961.
      View in: PubMed
    199. Chiu W, Baker ML, Jiang W, Dougherty M, Schmid MF. Electron cryomicroscopy of biological machines at subnanometer resolution. Structure. 2005 Mar; 13(3):363-72. PMID: 15766537.
      View in: PubMed
    200. Carson JP, Eichele G, Chiu W. A method for automated detection of gene expression required for the establishment of a digital transcriptome-wide gene expression atlas. J Microsc. 2005 Mar; 217(Pt 3):275-81. PMID: 15725131.
      View in: PubMed
    201. Topf M, Baker ML, John B, Chiu W, Sali A. Structural characterization of components of protein assemblies by comparative modeling and electron cryo-microscopy. J Struct Biol. 2005 Feb; 149(2):191-203. PMID: 15681235.
      View in: PubMed
    202. Serysheva II, Hamilton SL, Chiu W, Ludtke SJ. Structure of Ca2+ release channel at 14 A resolution. J Mol Biol. 2005 Jan 21; 345(3):427-31. PMID: 15581887.
      View in: PubMed
    203. Paredes A, Weaver S, Watowich S, Chiu W. Structural biology of old world and new world alphaviruses. Arch Virol Suppl. 2005; (19):179-85. PMID: 16358426.
      View in: PubMed
    204. Bello M, Ju T, Warren J, Carson J, Chiu W, Thaller C, Eichele G, Kakadiaris IA. Hybrid segmentation framework for tissue images containing gene expression data. Med Image Comput Comput Assist Interv. 2005; 8(Pt 1):254-61. PMID: 16685853.
      View in: PubMed
    205. Leung CW, Chiu WK. Clinical picture, diagnosis, treatment and outcome of severe acute respiratory syndrome (SARS) in children. Paediatr Respir Rev. 2004 Dec; 5(4):275-88. PMID: 15531251.
      View in: PubMed
    206. Schmid MF, Sherman MB, Matsudaira P, Chiu W. Structure of the acrosomal bundle. Nature. 2004 Sep 02; 431(7004):104-7. PMID: 15343340.
      View in: PubMed
    207. Chan CW, Chiu WK, Chan CC, Chow EY, Cheung HM, Ip PL. Osteonecrosis in children with severe acute respiratory syndrome. Pediatr Infect Dis J. 2004 Sep; 23(9):888-90. PMID: 15361738.
      View in: PubMed
    208. Booth CR, Jiang W, Baker ML, Zhou ZH, Ludtke SJ, Chiu W. A 9 angstroms single particle reconstruction from CCD captured images on a 200 kV electron cryomicroscope. J Struct Biol. 2004 Aug; 147(2):116-27. PMID: 15193640.
      View in: PubMed
    209. Mao Y, Vyas NK, Vyas MN, Chen DH, Ludtke SJ, Chiu W, Quiocho FA. Structure of the bifunctional and Golgi-associated formiminotransferase cyclodeaminase octamer. EMBO J. 2004 Aug 04; 23(15):2963-71. PMID: 15272307.
      View in: PubMed
    210. Paredes AM, Ferreira D, Horton M, Saad A, Tsuruta H, Johnston R, Klimstra W, Ryman K, Hernandez R, Chiu W, Brown DT. Conformational changes in Sindbis virions resulting from exposure to low pH and interactions with cells suggest that cell penetration may occur at the cell surface in the absence of membrane fusion. Virology. 2004 Jul 01; 324(2):373-86. PMID: 15207623.
      View in: PubMed
    211. Ludtke SJ, Chen DH, Song JL, Chuang DT, Chiu W. Seeing GroEL at 6 A resolution by single particle electron cryomicroscopy. Structure. 2004 Jul; 12(7):1129-36. PMID: 15242589.
      View in: PubMed
    212. Chiu WS, McManus JF, Notini AJ, Cassady AI, Zajac JD, Davey RA. Transgenic mice that express Cre recombinase in osteoclasts. Genesis. 2004 Jul; 39(3):178-85. PMID: 15282744.
      View in: PubMed
    213. Ng PC, Leung CW, Chiu WK, Wong SF, Hon EK. SARS in newborns and children. Biol Neonate. 2004; 85(4):293-8. PMID: 15218286.
      View in: PubMed
    214. Chen C, Ko Y, Delannoy M, Ludtke SJ, Chiu W, Pedersen PL. Mitochondrial ATP synthasome: three-dimensional structure by electron microscopy of the ATP synthase in complex formation with carriers for Pi and ADP/ATP. J Biol Chem. 2004 Jul 23; 279(30):31761-8. PMID: 15166242.
      View in: PubMed
    215. Brink J, Ludtke SJ, Kong Y, Wakil SJ, Ma J, Chiu W. Experimental verification of conformational variation of human fatty acid synthase as predicted by normal mode analysis. Structure. 2004 Feb; 12(2):185-91. PMID: 14962379.
      View in: PubMed
    216. Sherman MB, Orlova EV, Decker GL, Chiu W, Pownall HJ. Structure of triglyceride-rich human low-density lipoproteins according to cryoelectron microscopy. Biochemistry. 2003 Dec 23; 42(50):14988-93. PMID: 14674775.
      View in: PubMed
    217. Sherman MB, Chiu W. Electron beam coater for reduction of charging in ice-embedded biological specimens using Ti(88)Si(12) alloy. Microsc Microanal. 2003 Dec; 9(6):566-73. PMID: 14750991.
      View in: PubMed
    218. Ludtke SJ, Nason L, Tu H, Peng L, Chiu W. Object oriented database and electronic notebook for transmission electron microscopy. Microsc Microanal. 2003 Dec; 9(6):556-65. PMID: 14750990.
      View in: PubMed
    219. Lee S, Sowa ME, Watanabe YH, Sigler PB, Chiu W, Yoshida M, Tsai FT. The structure of ClpB: a molecular chaperone that rescues proteins from an aggregated state. Cell. 2003 Oct 17; 115(2):229-40. PMID: 14567920.
      View in: PubMed
    220. Ludtke SJ, Chiu W. Focal pair merging for contrast enhancement of single particles. J Struct Biol. 2003 Oct-Nov; 144(1-2):73-8. PMID: 14643210.
      View in: PubMed
    221. Jiang W, Baker ML, Wu Q, Bajaj C, Chiu W. Applications of a bilateral denoising filter in biological electron microscopy. J Struct Biol. 2003 Oct-Nov; 144(1-2):114-22. PMID: 14643214.
      View in: PubMed
    222. Baker ML, Jiang W, Bowman BR, Zhou ZH, Quiocho FA, Rixon FJ, Chiu W. Architecture of the herpes simplex virus major capsid protein derived from structural bioinformatics. J Mol Biol. 2003 Aug 08; 331(2):447-56. PMID: 12888351.
      View in: PubMed
    223. Chiu WK, Cheung PC, Ng KL, Ip PL, Sugunan VK, Luk DC, Ma LC, Chan BH, Lo KL, Lai WM. Severe acute respiratory syndrome in children: experience in a regional hospital in Hong Kong. Pediatr Crit Care Med. 2003 Jul; 4(3):279-83. PMID: 12831407.
      View in: PubMed
    224. Serysheva II, Bare DJ, Ludtke SJ, Kettlun CS, Chiu W, Mignery GA. Structure of the type 1 inositol 1,4,5-trisphosphate receptor revealed by electron cryomicroscopy. J Biol Chem. 2003 Jun 13; 278(24):21319-22. PMID: 12714606.
      View in: PubMed
    225. Bowman BR, Baker ML, Rixon FJ, Chiu W, Quiocho FA. Structure of the herpesvirus major capsid protein. EMBO J. 2003 Feb 17; 22(4):757-65. PMID: 12574112.
      View in: PubMed
    226. Jiang W, Li Z, Zhang Z, Baker ML, Prevelige PE, Chiu W. Coat protein fold and maturation transition of bacteriophage P22 seen at subnanometer resolutions. Nat Struct Biol. 2003 Feb; 10(2):131-5. PMID: 12536205.
      View in: PubMed
    227. Ko YH, Delannoy M, Hullihen J, Chiu W, Pedersen PL. Mitochondrial ATP synthasome. Cristae-enriched membranes and a multiwell detergent screening assay yield dispersed single complexes containing the ATP synthase and carriers for Pi and ADP/ATP. J Biol Chem. 2003 Apr 04; 278(14):12305-9. PMID: 12560333.
      View in: PubMed
    228. Paredes A, Alwell-Warda K, Weaver SC, Chiu W, Watowich SJ. Structure of isolated nucleocapsids from venezuelan equine encephalitis virus and implications for assembly and disassembly of enveloped virus. J Virol. 2003 Jan; 77(1):659-64. PMID: 12477868.
      View in: PubMed
    229. Zhou ZH, Chiu W. Determination of icosahedral virus structures by electron cryomicroscopy at subnanometer resolution. Adv Protein Chem. 2003; 64:93-124. PMID: 13677046.
      View in: PubMed
    230. Chiu W, Johnson JE. Virus structure. Preface. Adv Protein Chem. 2003; 64:xi-xii. PMID: 13677043.
      View in: PubMed
    231. Ju T, Warren J, Eichele G, Thaller C, Chiu W, Carson J. A geometric database for gene expression data. Symp Geom Process. 2003; 2003:166-176. PMID: 20631855.
      View in: PubMed
    232. Rixon FJ, Chiu W. Studying large viruses. Adv Protein Chem. 2003; 64:379-408. PMID: 13677054.
      View in: PubMed
    233. Baker ML, Serysheva II, Sencer S, Wu Y, Ludtke SJ, Jiang W, Hamilton SL, Chiu W. The skeletal muscle Ca2+ release channel has an oxidoreductase-like domain. Proc Natl Acad Sci U S A. 2002 Sep 17; 99(19):12155-60. PMID: 12218169.
      View in: PubMed
    234. Serysheva II, Ludtke SJ, Baker MR, Chiu W, Hamilton SL. Structure of the voltage-gated L-type Ca2+ channel by electron cryomicroscopy. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10370-5. PMID: 12149473.
      View in: PubMed
    235. Rockel B, Jakana J, Chiu W, Baumeister W. Electron cryo-microscopy of VAT, the archaeal p97/CDC48 homologue from Thermoplasma acidophilum. J Mol Biol. 2002 Apr 12; 317(5):673-81. PMID: 11955016.
      View in: PubMed
    236. Chiu W, Baker ML, Jiang W, Zhou ZH. Deriving folds of macromolecular complexes through electron cryomicroscopy and bioinformatics approaches. Curr Opin Struct Biol. 2002 Apr; 12(2):263-9. PMID: 11959506.
      View in: PubMed
    237. Yotnda P, Chen DH, Chiu W, Piedra PA, Davis A, Templeton NS, Brenner MK. Bilamellar cationic liposomes protect adenovectors from preexisting humoral immune responses. Mol Ther. 2002 Mar; 5(3):233-41. PMID: 11863412.
      View in: PubMed
    238. Chiu W, Rixon FJ. High resolution structural studies of complex icosahedral viruses: a brief overview. Virus Res. 2002 Jan 30; 82(1-2):9-17. PMID: 11885957.
      View in: PubMed
    239. Brink J, Ludtke SJ, Yang CY, Gu ZW, Wakil SJ, Chiu W. Quaternary structure of human fatty acid synthase by electron cryomicroscopy. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):138-43. PMID: 11756679.
      View in: PubMed
    240. Chen DH, Jakana J, McNab D, Mitchell J, Zhou ZH, Dougherty M, Chiu W, Rixon FJ. The pattern of tegument-capsid interaction in the herpes simplex virus type 1 virion is not influenced by the small hexon-associated protein VP26. J Virol. 2001 Dec; 75(23):11863-7. PMID: 11689667.
      View in: PubMed
    241. Jiang W, Li Z, Zhang Z, Booth CR, Baker ML, Chiu W. Semi-automated icosahedral particle reconstruction at sub-nanometer resolution. J Struct Biol. 2001 Dec; 136(3):214-25. PMID: 12051901.
      View in: PubMed
    242. Su CT, Yang HJ, Lin CF, Tsai MC, Shieh YH, Chiu WT. Arterial blood pressure and blood lipids as cardiovascular risk factors and occupational stress in Taiwan. Int J Cardiol. 2001 Dec; 81(2-3):181-7. PMID: 11744135.
      View in: PubMed
    243. Ludtke SJ, Jakana J, Song JL, Chuang DT, Chiu W. A 11.5 A single particle reconstruction of GroEL using EMAN. J Mol Biol. 2001 Nov 23; 314(2):253-62. PMID: 11718559.
      View in: PubMed
    244. Paredes A, Alwell-Warda K, Weaver SC, Chiu W, Watowich SJ. Venezuelan equine encephalomyelitis virus structure and its divergence from old world alphaviruses. J Virol. 2001 Oct; 75(19):9532-7. PMID: 11533216.
      View in: PubMed
    245. Wang YY, Hong CT, Chiu WT, Fang JY. In vitro and in vivo evaluations of topically applied capsaicin and nonivamide from hydrogels. Int J Pharm. 2001 Aug 14; 224(1-2):89-104. PMID: 11472818.
      View in: PubMed
    246. Jiang W, Chiu W. Web-based Simulation for Contrast Transfer Function and Envelope Functions. Microsc Microanal. 2001 Jul; 7(4):329-334. PMID: 12597807.
      View in: PubMed
    247. He J, Schmid MF, Zhou ZH, Rixon F, Chiu W. Finding and using local symmetry in identifying lower domain movements in hexon subunits of the herpes simplex virus type 1 B capsid. J Mol Biol. 2001 Jun 15; 309(4):903-14. PMID: 11399067.
      View in: PubMed
    248. Fang JY, Hong CT, Chiu WT, Wang YY. Effect of liposomes and niosomes on skin permeation of enoxacin. Int J Pharm. 2001 May 21; 219(1-2):61-72. PMID: 11337166.
      View in: PubMed
    249. Jiang W, Baker ML, Ludtke SJ, Chiu W. Bridging the information gap: computational tools for intermediate resolution structure interpretation. J Mol Biol. 2001 May 18; 308(5):1033-44. PMID: 11352589.
      View in: PubMed
    250. Saad A, Ludtke SJ, Jakana J, Rixon FJ, Tsuruta H, Chiu W. Fourier amplitude decay of electron cryomicroscopic images of single particles and effects on structure determination. J Struct Biol. 2001 Jan; 133(1):32-42. PMID: 11356062.
      View in: PubMed
    251. Thuman-Commike PA, Chiu W. Reconstruction principles of icosahedral virus structure determination using electron cryomicroscopy. Micron. 2000 Dec; 31(6):687-711. PMID: 10838029.
      View in: PubMed
    252. Huang HM, Lee MC, Lee SY, Chiu WT, Pan LC, Chen CT. Finite element analysis of brain contusion: an indirect impact study. Med Biol Eng Comput. 2000 May; 38(3):253-9. PMID: 10912340.
      View in: PubMed
    253. Chiu WT, Kuo CY, Hung CC, Chen M. The effect of the Taiwan motorcycle helmet use law on head injuries. Am J Public Health. 2000 May; 90(5):793-6. PMID: 10800433.
      View in: PubMed
    254. Zhang Z, Greene B, Thuman-Commike PA, Jakana J, Prevelige PE, King J, Chiu W. Visualization of the maturation transition in bacteriophage P22 by electron cryomicroscopy. J Mol Biol. 2000 Mar 31; 297(3):615-26. PMID: 10731416.
      View in: PubMed
    255. Li YC, Liu L, Chiu WT, Jian WS. Neural network modeling for surgical decisions on traumatic brain injury patients. Int J Med Inform. 2000 Jan; 57(1):1-9. PMID: 10708251.
      View in: PubMed
    256. Schmid MF, Sherman MB, Matsudaira P, Tsuruta H, Chiu W. Scaling structure factor amplitudes in electron cryomicroscopy using X-Ray solution scattering. J Struct Biol. 1999 Dec 01; 128(1):51-7. PMID: 10600558.
      View in: PubMed
    257. Sherman MB, Jakana J, Sun S, Matsudaira P, Chiu W, Schmid MF. The three-dimensional structure of the Limulus acrosomal process: a dynamic actin bundle. J Mol Biol. 1999 Nov 19; 294(1):139-49. PMID: 10556034.
      View in: PubMed
    258. Chen M, Shih JC, Chiu WT, Hsieh FJ. Separation of cesarean scar during second-trimester intravaginal misoprostol abortion. Obstet Gynecol. 1999 Nov; 94(5 Pt 2):840. PMID: 10546751.
      View in: PubMed
    259. Serysheva II, Schatz M, van Heel M, Chiu W, Hamilton SL. Structure of the skeletal muscle calcium release channel activated with Ca2+ and AMP-PCP. Biophys J. 1999 Oct; 77(4):1936-44. PMID: 10512814.
      View in: PubMed
    260. Huang HM, Lee MC, Chiu WT, Chen CT, Lee SY. Three-dimensional finite element analysis of subdural hematoma. J Trauma. 1999 Sep; 47(3):538-44. PMID: 10498311.
      View in: PubMed
    261. McGough A, Chiu W. ADF/cofilin weakens lateral contacts in the actin filament. J Mol Biol. 1999 Aug 20; 291(3):513-9. PMID: 10448032.
      View in: PubMed
    262. Saad A, Zhou ZH, Jakana J, Chiu W, Rixon FJ. Roles of triplex and scaffolding proteins in herpes simplex virus type 1 capsid formation suggested by structures of recombinant particles. J Virol. 1999 Aug; 73(8):6821-30. PMID: 10400780.
      View in: PubMed
    263. Orlova EV, Sherman MB, Chiu W, Mowri H, Smith LC, Gotto AM. Three-dimensional structure of low density lipoproteins by electron cryomicroscopy. Proc Natl Acad Sci U S A. 1999 Jul 20; 96(15):8420-5. PMID: 10411890.
      View in: PubMed
    264. Chiu WT, Chan P, Liao SS, Liou JR, Cheng JT. Effect of trilinolein on the activity and gene expression of superoxide dismutase in cultured rat brain astrocytes. Neurosci Lett. 1999 Jul 02; 269(1):17-20. PMID: 10821634.
      View in: PubMed
    265. Thuman-Commike PA, Greene B, Malinski JA, Burbea M, McGough A, Chiu W, Prevelige PE. Mechanism of scaffolding-directed virus assembly suggested by comparison of scaffolding-containing and scaffolding-lacking P22 procapsids. Biophys J. 1999 Jun; 76(6):3267-77. PMID: 10354452.
      View in: PubMed
    266. Tsauo JY, Hwang JS, Chiu WT, Hung CC, Wang JD. Estimation of expected utility gained from the helmet law in Taiwan by quality-adjusted survival time. Accid Anal Prev. 1999 May; 31(3):253-63. PMID: 10196602.
      View in: PubMed
    267. Chan P, Chiu WT, Chen YJ, Wu PJ, Cheng JT. Calcium influx inhibition: possible mechanism of the negative effect of tetrahydropalmatine on left ventricular pressure in isolated rat heart. Planta Med. 1999 May; 65(4):340-2. PMID: 10364840.
      View in: PubMed
    268. Thuman-Commike PA, Tsuruta H, Greene B, Prevelige PE, King J, Chiu W. Solution x-ray scattering-based estimation of electron cryomicroscopy imaging parameters for reconstruction of virus particles. Biophys J. 1999 Apr; 76(4):2249-61. PMID: 10096920.
      View in: PubMed
    269. Chiu W, McGough A, Sherman MB, Schmid MF. High-resolution electron cryomicroscopy of macromolecular assemblies. Trends Cell Biol. 1999 Apr; 9(4):154-9. PMID: 10203794.
      View in: PubMed
    270. Sherman MB, Soejima T, Chiu W, van Heel M. Multivariate analysis of single unit cells in electron crystallography. Ultramicroscopy. 1998 Sep; 74(4):179-99. PMID: 9809457.
      View in: PubMed
    271. Brink J, Gross H, Tittmann P, Sherman MB, Chiu W. Reduction of charging in protein electron cryomicroscopy. J Microsc. 1998 Jul; 191(Pt 1):67-73. PMID: 9723190.
      View in: PubMed
    272. Brink J, Sherman MB, Berriman J, Chiu W. Evaluation of charging on macromolecules in electron cryomicroscopy. Ultramicroscopy. 1998 Apr; 72(1-2):41-52. PMID: 9561796.
      View in: PubMed
    273. McGough A, Chiu W, Way M. Determination of the gelsolin binding site on F-actin: implications for severing and capping. Biophys J. 1998 Feb; 74(2 Pt 1):764-72. PMID: 9533689.
      View in: PubMed
    274. Paredes AM, Heidner H, Thuman-Commike P, Prasad BV, Johnston RE, Chiu W. Structural localization of the E3 glycoprotein in attenuated Sindbis virus mutants. J Virol. 1998 Feb; 72(2):1534-41. PMID: 9445057.
      View in: PubMed
    275. Zhou ZH, Chiu W, Haskell K, Spears H, Jakana J, Rixon FJ, Scott LR. Refinement of herpesvirus B-capsid structure on parallel supercomputers. Biophys J. 1998 Jan; 74(1):576-88. PMID: 9449358.
      View in: PubMed
    276. Sherman MB, Jakana J, Sun S, Matsudaira P, Chiu W, Schmid MF. A strategy for electron tomographic data collection and crystallographic reconstruction of biological bundles. J Struct Biol. 1997 Dec; 120(3):245-56. PMID: 9441930.
      View in: PubMed
    277. Sherman MB, Chiu W. Reliability of phases retrieved from 400-kV spot-scan images of purple membranes acquired on a slow-scan CCD camera. J Microsc. 1997 Dec; 188(Pt 3):285-9. PMID: 9450331.
      View in: PubMed
    278. Chen HY, Chiu WT, Chen SS, Lee LS, Hung CI, Hung CL, Wang YC, Hung CC, Lin LS, Shih YH. A nationwide epidemiological study of spinal cord injuries in Taiwan from July 1992 to June 1996. Neurol Res. 1997 Dec; 19(6):617-22. PMID: 9427963.
      View in: PubMed
    279. McGough A, Pope B, Chiu W, Weeds A. Cofilin changes the twist of F-actin: implications for actin filament dynamics and cellular function. J Cell Biol. 1997 Aug 25; 138(4):771-81. PMID: 9265645.
      View in: PubMed
    280. McAlarney ME, Chiu WK. Comparison of numeric techniques in the analysis of cleft palate dental arch form change. Cleft Palate Craniofac J. 1997 Jul; 34(4):281-91. PMID: 9257018.
      View in: PubMed
    281. Chiu WT, Yeh KH, Li YC, Gan YH, Chen HY, Hung CC. Traumatic brain injury registry in Taiwan. Neurol Res. 1997 Jun; 19(3):261-4. PMID: 9192378.
      View in: PubMed
    282. Chiu W, Avila-Sakar AJ, Schmid MF. Electron crystallography of macromolecular periodic arrays on phospholipid monolayers. Adv Biophys. 1997; 34:161-72. PMID: 9204133.
      View in: PubMed
    283. Chen HY, Chen SS, Chiu WT, Lee LS, Hung CI, Hung CL, Wang YC, Hung CC, Lin LS, Shih YH, Kuo CY. A nationwide epidemiological study of spinal cord injury in geriatric patients in Taiwan. Neuroepidemiology. 1997; 16(5):241-7. PMID: 9346344.
      View in: PubMed
    284. Prasad BV, Rothnagel R, Zeng CQ, Jakana J, Lawton JA, Chiu W, Estes MK. Visualization of ordered genomic RNA and localization of transcriptional complexes in rotavirus. Nature. 1996 Aug 01; 382(6590):471-3. PMID: 8684490.
      View in: PubMed
    285. Thuman-Commike PA, Greene B, Jakana J, Prasad BV, King J, Prevelige PE, Chiu W. Three-dimensional structure of scaffolding-containing phage p22 procapsids by electron cryo-microscopy. J Mol Biol. 1996 Jul 05; 260(1):85-98. PMID: 8676394.
      View in: PubMed
    286. Orlova EV, Serysheva II, van Heel M, Hamilton SL, Chiu W. Two structural configurations of the skeletal muscle calcium release channel. Nat Struct Biol. 1996 Jun; 3(6):547-52. PMID: 8646541.
      View in: PubMed
    287. Sherman MB, Brink J, Chiu W. Performance of a slow-scan CCD camera for macromolecular imaging in a 400 kV electron cryomicroscope. Micron. 1996 Apr; 27(2):129-39. PMID: 8858867.
      View in: PubMed
    288. Hung CC, Chiu WT, Lee LS, Lin LS, Shih CJ. Risk factors predicting surgically significant intracranial hematomas in patients with head injuries. J Formos Med Assoc. 1996 Apr; 95(4):294-7. PMID: 8935297.
      View in: PubMed
    289. Chang Z, Primm TP, Jakana J, Lee IH, Serysheva I, Chiu W, Gilbert HF, Quiocho FA. Mycobacterium tuberculosis 16-kDa antigen (Hsp16.3) functions as an oligomeric structure in vitro to suppress thermal aggregation. J Biol Chem. 1996 Mar 22; 271(12):7218-23. PMID: 8636160.
      View in: PubMed
    290. Chiu WT, Chen SY, Lin JW, Gan YH, Chiang MZ, Tseng CH, Chen JG. Color-Doppler Ultrasound-assisted endoscopic neurosurgery for intracerebral hemorrhage. Zhonghua Yi Xue Za Zhi (Taipei). 1996 Mar; 57(3):198-203. PMID: 8935226.
      View in: PubMed
    291. Avila-Sakar AJ, Chiu W. Visualization of beta-sheets and side-chain clusters in two-dimensional periodic arrays of streptavidin on phospholipid monolayers by electron crystallography. Biophys J. 1996 Jan; 70(1):57-68. PMID: 8770187.
      View in: PubMed
    292. Thuman-Commike PA, Chiu W. PTOOL: a software package for the selection of particles from electron cryomicroscopy spot-scan images. J Struct Biol. 1996 Jan-Feb; 116(1):41-7. PMID: 8742721.
      View in: PubMed
    293. Zhou ZH, Hardt S, Wang B, Sherman MB, Jakana J, Chiu W. CTF determination of images of ice-embedded single particles using a graphics interface. J Struct Biol. 1996 Jan-Feb; 116(1):216-22. PMID: 8742746.
      View in: PubMed
    294. Chiu WT, Kao TY, Lin MT. Interleukin-1 receptor antagonist increases survival in rat heatstroke by reducing hypothalamic serotonin release. Neurosci Lett. 1995 Dec 29; 202(1-2):33-6. PMID: 8787824.
      View in: PubMed
    295. Zhou ZH, He J, Jakana J, Tatman JD, Rixon FJ, Chiu W. Assembly of VP26 in herpes simplex virus-1 inferred from structures of wild-type and recombinant capsids. Nat Struct Biol. 1995 Nov; 2(11):1026-30. PMID: 7583656.
      View in: PubMed
    296. Chiu WT. The motorcycle helmet law in Taiwan. JAMA. 1995 Sep 27; 274(12):941-2. PMID: 7674519.
      View in: PubMed
    297. Lee MC, Chiu WT, Chang LT, Liu SC, Lin SH. Craniofacial injuries in unhelmeted riders of motorbikes. Injury. 1995 Sep; 26(7):467-70. PMID: 7493785.
      View in: PubMed
    298. Schmid MF, Jakana J, Chiu W, Matsudaira P. A 7-A projection map of frozen, hydrated acrosomal bundle from Limulus sperm. J Struct Biol. 1995 Sep-Oct; 115(2):209-13. PMID: 7577241.
      View in: PubMed
    299. Chiu WT, Hung CC, Shih CJ. Epidemiology of head injury in rural Taiwan -a four year survey. J Clin Neurosci. 1995 Jul; 2(3):210-5. PMID: 18638816.
      View in: PubMed
    300. Schmid MF, Jakana J, Matsudaira P, Chiu W. Three-dimensional structure of the acrosomal filament of Limulus sperm by 400 kV electron cryomicroscopy. Biophys J. 1995 Apr; 68(4 Suppl):8S-11S. PMID: 7787112.
      View in: PubMed
    301. Serysheva II, Orlova EV, Chiu W, Sherman MB, Hamilton SL, van Heel M. Electron cryomicroscopy and angular reconstitution used to visualize the skeletal muscle calcium release channel. Nat Struct Biol. 1995 Jan; 2(1):18-24. PMID: 7719847.
      View in: PubMed
    302. Zhou ZH, Prasad BV, Jakana J, Rixon FJ, Chiu W. Protein subunit structures in the herpes simplex virus A-capsid determined from 400 kV spot-scan electron cryomicroscopy. J Mol Biol. 1994 Sep 30; 242(4):456-69. PMID: 7932703.
      View in: PubMed
    303. Brink J, Chiu W. Applications of a slow-scan CCD camera in protein electron crystallography. J Struct Biol. 1994 Jul-Aug; 113(1):23-34. PMID: 7880650.
      View in: PubMed
    304. Avila-Sakar AJ, Guan TL, Arad T, Schmid MF, Loke TW, Yonath A, Piefke J, Franceschi F, Chiu W. Electron cryomicroscopy of Bacillus stearothermophilus 50 S ribosomal subunits crystallized on phospholipid monolayers. J Mol Biol. 1994 Jun 24; 239(5):689-97. PMID: 8014989.
      View in: PubMed
    305. Schmid MF, Agris JM, Jakana J, Matsudaira P, Chiu W. Three-dimensional structure of a single filament in the Limulus acrosomal bundle: scruin binds to homologous helix-loop-beta motifs in actin. J Cell Biol. 1994 Feb; 124(3):341-50. PMID: 8294517.
      View in: PubMed
    306. Schmid MF, Prasad BV, Chiu W. Structural studies of viruses by electron cryomicroscopy. Arch Virol Suppl. 1994; 9:523-9. PMID: 8032281.
      View in: PubMed
    307. Prasad BV, Chiu W. Structure of rotavirus. Curr Top Microbiol Immunol. 1994; 185:9-29. PMID: 8050286.
      View in: PubMed
    308. Chiu WT, LaPorte RE. Global Spine and Head Injury Prevention (SHIP) Project. J Trauma. 1993 Dec; 35(6):969-70. PMID: 8264006.
      View in: PubMed
    309. Shaw AL, Rothnagel R, Chen D, Ramig RF, Chiu W, Prasad BV. Three-dimensional visualization of the rotavirus hemagglutinin structure. Cell. 1993 Aug 27; 74(4):693-701. PMID: 8395350.
      View in: PubMed
    310. Chiu W, Schmid MF. Electron crystallography of macromolecules. Curr Opin Biotechnol. 1993 Aug; 4(4):397-402. PMID: 7763969.
      View in: PubMed
    311. Chiu WT, Dearwater SR, McCarty DJ, Songer TJ, LaPorte RE. Establishment of accurate incidence rates for head and spinal cord injuries in developing and developed countries: a capture-recapture approach. J Trauma. 1993 Aug; 35(2):206-11. PMID: 8355297.
      View in: PubMed
    312. Soejima T, Sherman MB, Schmid MF, Chiu W. 4-A projection map of bacteriophage T4 DNA helix-destabilizing protein (gp32*I) crystal by 400-kV electron cryomicroscopy. J Struct Biol. 1993 Jul-Aug; 111(1):9-16. PMID: 8251266.
      View in: PubMed
    313. Prasad BV, Prevelige PE, Marietta E, Chen RO, Thomas D, King J, Chiu W. Three-dimensional transformation of capsids associated with genome packaging in a bacterial virus. J Mol Biol. 1993 May 05; 231(1):65-74. PMID: 8496966.
      View in: PubMed
    314. Chiu W, Schmid MF, Prasad BV. Teaching electron diffraction and imaging of macromolecules. Biophys J. 1993 May; 64(5):1610-25. PMID: 8324196.
      View in: PubMed
    315. Chiu WT, Lin LS, Lin MT. Antagonistic effects of lesions of paramedian reticular nucleus on amphetamine-induced locomotion and striatal dopamine release in rats. Neurosci Res. 1993 May; 16(4):311-4. PMID: 8394558.
      View in: PubMed
    316. Schmid MF, Jakana J, Matsudaira P, Chiu W. Imaging frozen, hydrated acrosomal bundle from Limulus sperm at 7 A resolution with a 400 kV electron cryomicroscope. J Mol Biol. 1993 Mar 20; 230(2):384-6. PMID: 8464053.
      View in: PubMed
    317. Chiu WT, Lin WY, Lin LS, Hung CC, Shih CJ. Neurobehavioral manifestations following closed head injury. J Formos Med Assoc. 1993 Mar; 92(3):255-62. PMID: 8102280.
      View in: PubMed
    318. Zhou ZH, Chiu W. Prospects for using an IVEM with a FEG for imaging macromolecules towards atomic resolution. Ultramicroscopy. 1993 Feb; 49(1-4):407-16. PMID: 8475604.
      View in: PubMed
    319. Avila-Sakar AJ, Schmid MF, Li LS, Whitby FG, Phillips GN, Chiu W. Preliminary electron crystallographic analysis of ice-embedded tropomyosin crystals. J Struct Biol. 1993 Jan-Feb; 110(1):67-74. PMID: 8494673.
      View in: PubMed
    320. Chiu W. What does electron cryomicroscopy provide that X-ray crystallography and NMR spectroscopy cannot? Annu Rev Biophys Biomol Struct. 1993; 22:233-55. PMID: 8347990.
      View in: PubMed
    321. Brink J, Chiu W, Dougherty M. Computer-controlled spot-scan imaging of crotoxin complex crystals with 400 keV electrons at near-atomic resolution. Ultramicroscopy. 1992 Oct; 46(1-4):229-40. PMID: 1481273.
      View in: PubMed
    322. Lee LS, Shih YH, Chiu WT, Lin LS, Wu CM, Wang YC, Huang JS, Hung CC, Shih CJ, Laporte RE. [Epidemiologic study of head injuries in Taipei City, Taiwan]. Zhonghua Yi Xue Za Zhi (Taipei). 1992 Sep; 50(3):219-25. PMID: 1330249.
      View in: PubMed
    323. Schmid MF, Jakana J, Matsudaira P, Chiu W. Effects of radiation damage with 400-kV electrons on frozen, hydrated actin bundles. J Struct Biol. 1992 Jan-Feb; 108(1):62-8. PMID: 1562434.
      View in: PubMed
    324. Hung CC, Chiu WT, Tsai JC, Laporte RE, Shih CJ. [An epidemiological study of head injury in Hualien County, Taiwan]. J Formos Med Assoc. 1991 Dec; 90(12):1227-33. PMID: 1686894.
      View in: PubMed
    325. Liu JS, Chiu WT, Lin LS, Hang CC. [Trauma score and injury severity score in evaluation of the trauma patients: a preliminary report of 1000 cases]. Zhonghua Yi Xue Za Zhi (Taipei). 1991 Oct; 48(4):297-304. PMID: 1659926.
      View in: PubMed
    326. Schmid MF, Matsudaira P, Jeng TW, Jakana J, Towns-Andrews E, Bordas J, Chiu W. Crystallographic analysis of acrosomal bundle from Limulus sperm. J Mol Biol. 1991 Sep 20; 221(2):711-25. PMID: 1920441.
      View in: PubMed
    327. Wong CL, Chiu WT, Wang JH. [Tolosa-Hunt syndrome--case report]. Zhonghua Yi Xue Za Zhi (Taipei). 1991 Jul; 48(1):71-5. PMID: 1653097.
      View in: PubMed
    328. Brink J, Chiu W. Contrast analysis of cryo-images of n-paraffin recorded at 400 kV out to 2.1 A resolution. J Microsc. 1991 Feb; 161(Pt 2):279-95. PMID: 2038034.
      View in: PubMed
    329. Prasad BV, Degn LL, Jeng TW, Chiu W. Estimation of allowable errors for tilt parameter determination in protein electron crystallography. Ultramicroscopy. 1990 Oct; 33(4):281-5. PMID: 2260229.
      View in: PubMed
    330. Prasad BV, Burns JW, Marietta E, Estes MK, Chiu W. Localization of VP4 neutralization sites in rotavirus by three-dimensional cryo-electron microscopy. Nature. 1990 Feb 01; 343(6257):476-9. PMID: 2153941.
      View in: PubMed
    331. Lin LS, Chiu WT, Shih CJ, Lin MT. Influence of thermal stress and various agents on the brain edema formation in rats following a cryogenic brain lesion. Chin J Physiol. 1989; 32(1):41-7. PMID: 2517859.
      View in: PubMed
    332. Chiu WT, Shih CJ, Chen HY, Lin LS. Neurogenic pulmonary edema. Zhonghua Yi Xue Za Zhi (Taipei). 1987 Sep; 40(3):283-8. PMID: 3502845.
      View in: PubMed
    333. Chiu WT, Lin LS, Shih CJ, Lin MT. Bombesin-induced hypothermia: possible involvement of cholinergic and dopaminergic receptors in the rat hypothalamus. Exp Neurol. 1987 Feb; 95(2):368-77. PMID: 2879738.
      View in: PubMed
    334. Lin LS, Chiu WT, Shih CJ, Lin MT. Involvement of both opiate and catecholaminergic receptors of ventromedial hypothalamus in the locomotor stimulant action of thyrotropin-releasing hormone. J Neural Transm. 1987; 68(3-4):217-25. PMID: 3031208.
      View in: PubMed
    335. Lin LS, Chiu WT, Lin MT, Shih CJ. Alterations in physiological functions and in brain monoamine content in the sympathectomized rats. Proc Natl Sci Counc Repub China B. 1986 Jul; 10(3):191-5. PMID: 2877471.
      View in: PubMed
    336. Chiu WT, Shih CJ, Chen HY, Lin LS. Treatment of central diabetes insipidus with DDAVP. Taiwan Yi Xue Hui Za Zhi. 1985 Aug; 84(8):944-52. PMID: 3865998.
      View in: PubMed
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