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TSE-HUA TAN

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
DivisionImmunology
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    R01GM049875     (TAN, TSE-HUA)Aug 1, 1993 - Jul 31, 1998
    NIH/NIGMS
    PROTEIN-PROTEIN INTERACTIONS INVOLVED IN C-REL FUNCTION
    Role: Principal Investigator

    R01AI038649     (TAN, TSE-HUA)Jul 1, 1995 - Jun 30, 2000
    NIH/NIAID
    JNK KINASE AND REL/NF/KB IN CD28 SIGNAL TRANSDUCTION
    Role: Principal Investigator

    T32AI007495     (TAN, TSE-HUA)May 1, 1996 - Jul 31, 2013
    NIH/NIAID
    Molecular and Cellular Mechanisms of Host Defense
    Role: Principal Investigator

    R01AI042532     (TAN, TSE-HUA)Sep 1, 1998 - Aug 31, 2004
    NIH/NIAID
    HPK1 MEDIATED T CELL SIGNAL TRANSDUCTION MECHANISMS
    Role: Principal Investigator

    R56AI042532     (TAN, TSE-HUA)Sep 1, 1998 - Feb 28, 2007
    NIH/NIAID
    HPK1-Mediated Lymphocyte Signal Transduction Mechanisms
    Role: Principal Investigator

    R01CA087076     (TAN, TSE-HUA)Apr 1, 2002 - Mar 31, 2008
    NIH/NCI
    Protein Phosphatases and Proinflammatory Cytokines
    Role: Principal Investigator

    R21CA112475     (TAN, TSE-HUA)Apr 18, 2005 - Mar 31, 2008
    NIH/NCI
    PP4 and IGF-1 Signaling in Breast Tumorigenesis
    Role: Principal Investigator

    R01AI066895     (TAN, TSE-HUA)Jul 1, 2005 - Mar 31, 2011
    NIH/NIAID
    Protein Phosphatases in Lymphocyte Signal Transduction
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chuang HC, Tsai CY, Hsueh CH, Tan TH. GLK-IKKß signaling induces dimerization and translocation of the AhR-ROR?t complex in IL-17A induction and autoimmune disease. Sci Adv. 2018 09; 4(9):eaat5401. PMID: 30214937.
      View in: PubMed
    2. Peng HY, Liang YC, Tan TH, Chuang HC, Lin YJ, Lin JC. RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis. Int J Mol Sci. 2018 Sep 06; 19(9). PMID: 30200638.
      View in: PubMed
    3. Hsu WC, Chen MY, Hsu SC, Huang LR, Kao CY, Cheng WH, Pan CH, Wu MS, Yu GY, Hung MS, Leu CM, Tan TH, Su YW. DUSP6 mediates T cell receptor-engaged glycolysis and restrains TFH cell differentiation. Proc Natl Acad Sci U S A. 2018 08 21; 115(34):E8027-E8036. PMID: 30087184.
      View in: PubMed
    4. Yang CY, Chiu LL, Chang CC, Chuang HC, Tan TH. Induction of DUSP14 ubiquitination by PRMT5-mediated arginine methylation. FASEB J. 2018 Jun 19; fj201800244RR. PMID: 29920217.
      View in: PubMed
    5. Lin JC, Lee YC, Tan TH, Liang YC, Chuang HC, Fann YC, Johnson KR, Lin YJ. RBM4-SRSF3-MAP4K4 splicing cascade modulates the metastatic signature of colorectal cancer cell. Biochim Biophys Acta Mol Cell Res. 2018 Feb; 1865(2):259-272. PMID: 29138007.
      View in: PubMed
    6. Chuang HC, Tan TH. MAP4K4 and IL-6+ Th17 cells play important roles in non-obese type 2 diabetes. J Biomed Sci. 2017 Jan 07; 24(1):4. PMID: 28061846.
      View in: PubMed
    7. Chuang HC, Chen YM, Hung WT, Li JP, Chen DY, Lan JL, Tan TH. Downregulation of the phosphatase JKAP/DUSP22 in T cells as a potential new biomarker of systemic lupus erythematosus nephritis. Oncotarget. 2016 Sep 06; 7(36):57593-57605. PMID: 27557500.
      View in: PubMed
    8. Ho CH, Chuang HC, Wu IC, Tsai HW, Lin YJ, Sun HY, Young KC, Chiu YC, Cheng PN, Liu WC, Tan TH, Chang TT. Prediction of early hepatocellular carcinoma recurrence using germinal center kinase-like kinase. Oncotarget. 2016 Aug 02; 7(31):49765-49776. PMID: 27343552.
      View in: PubMed
    9. Hsu CP, Chuang HC, Lee MC, Tsou HH, Lee LW, Li JP, Tan TH. GLK/MAP4K3 overexpression associates with recurrence risk for non-small cell lung cancer. Oncotarget. 2016 Jul 05; 7(27):41748-41757. PMID: 27203390.
      View in: PubMed
    10. Chuang HC, Wang JS, Lee IT, Sheu WH, Tan TH. Epigenetic regulation of HGK/MAP4K4 in T cells of type 2 diabetes patients. Oncotarget. 2016 Mar 08; 7(10):10976-89. PMID: 26918832.
      View in: PubMed
    11. Yang CY, Chiu LL, Tan TH. TRAF2-mediated Lys63-linked ubiquitination of DUSP14/MKP6 is essential for its phosphatase activity. Cell Signal. 2016 Jan; 28(1):145-51. PMID: 26521044.
      View in: PubMed
    12. Chuang HC, Wang X, Tan TH. MAP4K Family Kinases in Immunity and Inflammation. Adv Immunol. 2016; 129:277-314. PMID: 26791862.
      View in: PubMed
    13. Chen MY, Chen YP, Wu MS, Yu GY, Lin WJ, Tan TH, Su YW. PP4 is essential for germinal center formation and class switch recombination in mice. PLoS One. 2014; 9(9):e107505. PMID: 25215539.
      View in: PubMed
    14. Chuang HC, Sheu WH, Lin YT, Tsai CY, Yang CY, Cheng YJ, Huang PY, Li JP, Chiu LL, Wang X, Xie M, Schneider MD, Tan TH. HGK/MAP4K4 deficiency induces TRAF2 stabilization and Th17 differentiation leading to insulin resistance. Nat Commun. 2014 Aug 06; 5:4602. PMID: 25098764.
      View in: PubMed
    15. Seeley-Fallen MK, Liu LJ, Shapiro MR, Onabajo OO, Palaniyandi S, Zhu X, Tan TH, Upadhyaya A, Song W. Actin-binding protein 1 links B-cell antigen receptors to negative signaling pathways. Proc Natl Acad Sci U S A. 2014 Jul 08; 111(27):9881-6. PMID: 24958882.
      View in: PubMed
    16. Liao FH, Shui JW, Hsing EW, Hsiao WY, Lin YC, Chan YC, Tan TH, Huang CY. Protein phosphatase 4 is an essential positive regulator for Treg development, function, and protective gut immunity. Cell Biosci. 2014; 4:25. PMID: 24904742.
      View in: PubMed
    17. Li JP, Yang CY, Chuang HC, Lan JL, Chen DY, Chen YM, Wang X, Chen AJ, Belmont JW, Tan TH. The phosphatase JKAP/DUSP22 inhibits T-cell receptor signalling and autoimmunity by inactivating Lck. Nat Commun. 2014 Apr 09; 5:3618. PMID: 24714587.
      View in: PubMed
    18. Yang CY, Li JP, Chiu LL, Lan JL, Chen DY, Chuang HC, Huang CY, Tan TH. Dual-specificity phosphatase 14 (DUSP14/MKP6) negatively regulates TCR signaling by inhibiting TAB1 activation. J Immunol. 2014 Feb 15; 192(4):1547-57. PMID: 24403530.
      View in: PubMed
    19. Wang H, Chen Y, Lin P, Li L, Zhou G, Liu G, Logsdon C, Jin J, Abbruzzese JL, Tan TH, Wang H. The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1. J Biol Chem. 2014 Feb 14; 289(7):4009-17. PMID: 24362026.
      View in: PubMed
    20. Chen YM, Chuang HC, Lin WC, Tsai CY, Wu CW, Gong NR, Hung WT, Lan TH, Lan JL, Tan TH, Chen DY. Germinal center kinase-like kinase overexpression in T cells as a novel biomarker in rheumatoid arthritis. Arthritis Rheum. 2013 Oct; 65(10):2573-82. PMID: 23817999.
      View in: PubMed
    21. Wang X, Li JP, Chiu LL, Lan JL, Chen DY, Boomer J, Tan TH. Attenuation of T cell receptor signaling by serine phosphorylation-mediated lysine 30 ubiquitination of SLP-76 protein. J Biol Chem. 2012 Oct 05; 287(41):34091-100. PMID: 22902619.
      View in: PubMed
    22. Chen DY, Chuang HC, Lan JL, Chen YM, Hung WT, Lai KL, Tan TH. Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker. BMC Med. 2012 Aug 06; 10:84. PMID: 22867055.
      View in: PubMed
    23. Chen KR, Chang CH, Huang CY, Lin CY, Lin WY, Lo YC, Yang CY, Hsing EW, Chen LF, Shih SR, Shiau AL, Lei HY, Tan TH, Ling P. TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity. J Biol Chem. 2012 Sep 14; 287(38):32216-21. PMID: 22833682.
      View in: PubMed
    24. Wang X, Chuang HC, Li JP, Tan TH. Regulation of PKC-? function by phosphorylation in T cell receptor signaling. Front Immunol. 2012; 3:197. PMID: 22798961.
      View in: PubMed
    25. Wang X, Li JP, Kuo HK, Chiu LL, Dement GA, Lan JL, Chen DY, Yang CY, Hu H, Tan TH. Down-regulation of B cell receptor signaling by hematopoietic progenitor kinase 1 (HPK1)-mediated phosphorylation and ubiquitination of activated B cell linker protein (BLNK). J Biol Chem. 2012 Mar 30; 287(14):11037-48. PMID: 22334673.
      View in: PubMed
    26. Huang CY, Lin YC, Hsiao WY, Liao FH, Huang PY, Tan TH. DUSP4 deficiency enhances CD25 expression and CD4+ T-cell proliferation without impeding T-cell development. Eur J Immunol. 2012 Feb; 42(2):476-88. PMID: 22101742.
      View in: PubMed
    27. Chuang HC, Lan JL, Chen DY, Yang CY, Chen YM, Li JP, Huang CY, Liu PE, Wang X, Tan TH. The kinase GLK controls autoimmunity and NF-?B signaling by activating the kinase PKC-? in T cells. Nat Immunol. 2011 Oct 09; 12(11):1113-8. PMID: 21983831.
      View in: PubMed
    28. Li JP, Fu YN, Chen YR, Tan TH. JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration. J Biol Chem. 2010 Feb 19; 285(8):5472-8. PMID: 20018849.
      View in: PubMed
    29. Tucker KL, Kaiser WJ, Bergeron AL, Hu H, Dong JF, Tan TH, Gibbins JM. Proteomic analysis of resting and thrombin-stimulated platelets reveals the translocation and functional relevance of HIP-55 in platelets. Proteomics. 2009 Sep; 9(18):4340-54. PMID: 19725075.
      View in: PubMed
    30. Wang H, Song X, Logsdon C, Zhou G, Evans DB, Abbruzzese JL, Hamilton SR, Tan TH, Wang H. Proteasome-mediated degradation and functions of hematopoietic progenitor kinase 1 in pancreatic cancer. Cancer Res. 2009 Feb 01; 69(3):1063-70. PMID: 19141650.
      View in: PubMed
    31. Liang JJ, Wang H, Rashid A, Tan TH, Hwang RF, Hamilton SR, Abbruzzese JL, Evans DB, Wang H. Expression of MAP4K4 is associated with worse prognosis in patients with stage II pancreatic ductal adenocarcinoma. Clin Cancer Res. 2008 Nov 01; 14(21):7043-9. PMID: 18981001.
      View in: PubMed
    32. Onabajo OO, Seeley MK, Kale A, Qualmann B, Kessels M, Han J, Tan TH, Song W. Actin-binding protein 1 regulates B cell receptor-mediated antigen processing and presentation in response to B cell receptor activation. J Immunol. 2008 May 15; 180(10):6685-95. PMID: 18453588.
      View in: PubMed
    33. Chen M, Guerrero AD, Huang L, Shabier Z, Pan M, Tan TH, Wang J. Caspase-9-induced mitochondrial disruption through cleavage of anti-apoptotic BCL-2 family members. J Biol Chem. 2007 Nov 16; 282(46):33888-95. PMID: 17893147.
      View in: PubMed
    34. Shui JW, Boomer JS, Han J, Xu J, Dement GA, Zhou G, Tan TH. Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses. Nat Immunol. 2007 Jan; 8(1):84-91. PMID: 17115060.
      View in: PubMed
    35. Shui JW, Hu MC, Tan TH. Conditional knockout mice reveal an essential role of protein phosphatase 4 in thymocyte development and pre-T-cell receptor signaling. Mol Cell Biol. 2007 Jan; 27(1):79-91. PMID: 17060460.
      View in: PubMed
    36. Wang JY, Lin CH, Yang CH, Tan TH, Chen YR. Biochemical and biological characterization of a neuroendocrine-associated phosphatase. J Neurochem. 2006 Jul; 98(1):89-101. PMID: 16805799.
      View in: PubMed
    37. Yang HS, Matthews CP, Clair T, Wang Q, Baker AR, Li CC, Tan TH, Colburn NH. Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion. Mol Cell Biol. 2006 Feb; 26(4):1297-306. PMID: 16449643.
      View in: PubMed
    38. Han J, Shui JW, Zhang X, Zheng B, Han S, Tan TH. HIP-55 is important for T-cell proliferation, cytokine production, and immune responses. Mol Cell Biol. 2005 Aug; 25(16):6869-78. PMID: 16055701.
      View in: PubMed
    39. Boomer JS, Tan TH. Functional interactions of HPK1 with adaptor proteins. J Cell Biochem. 2005 May 01; 95(1):34-44. PMID: 15770651.
      View in: PubMed
    40. Zhang X, Ozawa Y, Lee H, Wen YD, Tan TH, Wadzinski BE, Seto E. Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4. Genes Dev. 2005 Apr 01; 19(7):827-39. PMID: 15805470.
      View in: PubMed
    41. MacCorkle RA, Tan TH. Mitogen-activated protein kinases in cell-cycle control. Cell Biochem Biophys. 2005; 43(3):451-61. PMID: 16244369.
      View in: PubMed
    42. Zhou G, Boomer JS, Tan TH. Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1. J Biol Chem. 2004 Nov 19; 279(47):49551-61. PMID: 15364934.
      View in: PubMed
    43. Mihindukulasuriya KA, Zhou G, Qin J, Tan TH. Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation. J Biol Chem. 2004 Nov 05; 279(45):46588-94. PMID: 15331607.
      View in: PubMed
    44. MacCorkle RA, Tan TH. Inhibition of JNK2 disrupts anaphase and produces aneuploidy in mammalian cells. J Biol Chem. 2004 Sep 17; 279(38):40112-21. PMID: 15262983.
      View in: PubMed
    45. Shui JW, Tan TH. Germline transmission and efficient DNA recombination in mouse embryonic stem cells mediated by adenoviral-Cre transduction. Genesis. 2004 Jul; 39(3):217-23. PMID: 15282749.
      View in: PubMed
    46. Zheng B, Marinova E, Han J, Tan TH, Han S. Cutting edge: gamma delta T cells provide help to B cells with altered clonotypes and are capable of inducing Ig gene hypermutation. J Immunol. 2003 Nov 15; 171(10):4979-83. PMID: 14607892.
      View in: PubMed
    47. Han J, Kori R, Shui JW, Chen YR, Yao Z, Tan TH. The SH3 domain-containing adaptor HIP-55 mediates c-Jun N-terminal kinase activation in T cell receptor signaling. J Biol Chem. 2003 Dec 26; 278(52):52195-202. PMID: 14557276.
      View in: PubMed
    48. Chen YR, Han J, Kori R, Kong AN, Tan TH. Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase. J Biol Chem. 2002 Oct 18; 277(42):39334-42. PMID: 12171915.
      View in: PubMed
    49. Chen AJ, Zhou G, Juan T, Colicos SM, Cannon JP, Cabriera-Hansen M, Meyer CF, Jurecic R, Copeland NG, Gilbert DJ, Jenkins NA, Fletcher F, Tan TH, Belmont JW. The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway. J Biol Chem. 2002 Sep 27; 277(39):36592-601. PMID: 12138158.
      View in: PubMed
    50. Zhou G, Mihindukulasuriya KA, MacCorkle-Chosnek RA, Van Hooser A, Hu MC, Brinkley BR, Tan TH. Protein phosphatase 4 is involved in tumor necrosis factor-alpha-induced activation of c-Jun N-terminal kinase. J Biol Chem. 2002 Feb 22; 277(8):6391-8. PMID: 11698396.
      View in: PubMed
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