TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
Address1102 BATES
Houston, TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pediatrics

    Collapse Research 
    Collapse research activities and funding
    R21DK078032     (SAVIDGE, TOR)Jun 1, 2009 - May 31, 2012
    S-nitrosoglutathione regulation of intestinal barrier function in Crohn's disease
    Role: Principal Investigator

    R01AI100914     (SAVIDGE, TOR)Jun 1, 2012 - May 31, 2018
    Allosteric therapy of the Clostridium difficile toxins
    Role: Principal Investigator

    R21DK096323     (SAVIDGE, TOR)Sep 15, 2014 - Aug 31, 2016
    Metabolome-Based Biomarkers and Neutraceuticals in Clostridium Difficile Infection
    Role: Principal Investigator

    U01AI124290     (SAVIDGE, TOR)Aug 20, 2016 - Jul 31, 2021
    Decoding Antibiotic-induced Susceptibility to Clostridium difficile Infection
    Role: Principal Investigator

    P01AI152999     (ARIAS, CESAR AUGUSTO)Aug 1, 2020 - Jul 31, 2025
    Dynamics of Colonization and Infection by Multidrug-resistant Pathogens in Immunocompromised and Critically Ill Patients (DYNAMITE)
    Role: Co-Principal Investigator

    R01DK130517     (MARGOLIS, KARA GROSS)Aug 15, 2021 - Jul 31, 2025
    A Prospective Study Examining the Role of Gestational SSRI Exposure in the Development of Functional Gastrointestinal Disorders
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. So SY, Wu Q, Leung KS, Kundi ZM, Savidge TC, El-Nezami H. Yeast ß-glucan reduces obesity-associated Bilophila abundance and modulates bile acid metabolism in healthy and high-fat diet mouse models. Am J Physiol Gastrointest Liver Physiol. 2021 Oct 13. PMID: 34643089.
    2. Blutt SE, Crawford SE, Bomidi C, Zeng XL, Broughman JR, Robertson M, Coarfa C, Tessier MEM, Savidge T, Hollinger FB, Curley SA, Donowitz M, Estes MK. Use of human tissue stem cell-derived organoid cultures to model enterohepatic circulation. Am J Physiol Gastrointest Liver Physiol. 2021 09 01; 321(3):G270-G279. PMID: 34288725.
      Citations:    Fields:    Translation:HumansCells
    3. Kvakova M, Bertkova I, Stofilova J, Savidge TC. Co-Encapsulated Synbiotics and Immobilized Probiotics in Human Health and Gut Microbiota Modulation. Foods. 2021 Jun 04; 10(6). PMID: 34200108.
    4. Miles-Jay A, Young VB, Pamer EG, Savidge TC, Kamboj M, Garey KW, Snitkin ES. A multisite genomic epidemiology study of Clostridioides difficile infections in the USA supports differential roles of healthcare versus community spread for two common strains. Microb Genom. 2021 06; 7(6). PMID: 34180789.
      Citations:    Fields:    
    5. Gonzales-Luna AJ, Spinler JK, Oezguen N, Khan MAW, Danhof HA, Endres BT, Alam MJ, Begum K, Lancaster C, Costa GP, Savidge TC, Hurdle JG, Britton R, Garey KW. Systems biology evaluation of refractory Clostridioides difficile infection including multiple failures of fecal microbiota transplantation. Anaerobe. 2021 Aug; 70:102387. PMID: 34044101.
      Citations:    Fields:    
    6. So SY, Savidge TC. Sex-Bias in Irritable Bowel Syndrome: Linking Steroids to the Gut-Brain Axis. Front Endocrinol (Lausanne). 2021; 12:684096. PMID: 34093447.
      Citations: 1     
    7. Aitken SL, Sahasrabhojane PV, Kontoyiannis DP, Savidge TC, Arias CA, Ajami NJ, Shelburne SA, Galloway-Peña JR. Alterations of the Oral Microbiome and Cumulative Carbapenem Exposure Are Associated With Stenotrophomonas maltophilia Infection in Patients With Acute Myeloid Leukemia Receiving Chemotherapy. Clin Infect Dis. 2021 05 04; 72(9):1507-1513. PMID: 32544947.
      Citations: 1     Fields:    Translation:HumansCells
    8. Kamp KJ, Plantinga AM, Cain KC, Burr RL, Barney P, Jarrett M, Luna RA, Savidge T, Shulman R, Heitkemper MM. A Comprehensive Self-Management Program With Diet Education Does Not Alter Microbiome Characteristics in Women With Irritable Bowel Syndrome. Biol Res Nurs. 2021 07; 23(3):471-480. PMID: 33412896.
      Citations:    Fields:    Translation:Humans
    9. Hegde S, Lin YM, Fu Y, Savidge T, Shi XZ. Precision Lactobacillus reuteri therapy attenuates luminal distension-associated visceral hypersensitivity by inducing peripheral opioid receptors in the colon. Pain. 2020 12; 161(12):2737-2749. PMID: 32569084.
      Citations: 1     Fields:    Translation:AnimalsCells
    10. Engevik MA, Danhof HA, Auchtung J, Endres BT, Ruan W, Bassères E, Engevik AC, Wu Q, Nicholson M, Luna RA, Garey KW, Crawford SE, Estes MK, Lux R, Yacyshyn MB, Yacyshyn B, Savidge T, Britton RA, Versalovic J. Fusobacteriumnucleatum Adheres to Clostridioides difficile via the RadD Adhesin to Enhance Biofilm Formation in Intestinal Mucus. Gastroenterology. 2021 03; 160(4):1301-1314.e8. PMID: 33227279.
      Citations: 4     Fields:    Translation:HumansCells
    11. Norsigian CJ, Danhof HA, Brand CK, Oezguen N, Midani FS, Palsson BO, Savidge TC, Britton RA, Spinler JK, Monk JM. Systems biology analysis of the Clostridioides difficile core-genome contextualizes microenvironmental evolutionary pressures leading to genotypic and phenotypic divergence. NPJ Syst Biol Appl. 2020 10 20; 6(1):31. PMID: 33082337.
      Citations: 1     Fields:    
    12. Savidge T. Predicting Inflammatory Bowel Disease Symptoms Onset: Nitrous Take on Gut Bacteria Is No Laughing Matter. Cell Mol Gastroenterol Hepatol. 2021; 11(2):661-662. PMID: 33065091.
      Citations: 1     Fields:    Translation:HumansCells
    13. Foong JPP, Hung LY, Poon S, Savidge TC, Bornstein JC. Early life interaction between the microbiota and the enteric nervous system. Am J Physiol Gastrointest Liver Physiol. 2020 11 01; 319(5):G541-G548. PMID: 32902314.
      Citations: 5     Fields:    Translation:HumansAnimals
    14. Hung LY, Parathan P, Boonma P, Wu Q, Wang Y, Haag A, Luna RA, Bornstein JC, Savidge TC, Foong JPP. Antibiotic exposure postweaning disrupts the neurochemistry and function of enteric neurons mediating colonic motor activity. Am J Physiol Gastrointest Liver Physiol. 2020 06 01; 318(6):G1042-G1053. PMID: 32390463.
      Citations: 2     Fields:    Translation:Animals
    15. Kociolek LK, Espinosa RO, Gerding DN, Hauser AR, Ozer EA, Budz M, Balaji A, Chen X, Tanz RR, Yalcinkaya N, Conner ME, Savidge T, Kelly CP. Natural Clostridioides difficile Toxin Immunization in Colonized Infants. Clin Infect Dis. 2020 05 06; 70(10):2095-2102. PMID: 31253983.
      Citations: 6     Fields:    Translation:HumansPHPublic Health
    16. Wu Q, Savidge TC. Systems approaches for the clinical diagnosis of Clostridioides difficile infection. Transl Res. 2020 06; 220:57-67. PMID: 32272094.
      Citations: 1     Fields:    Translation:Humans
    17. Andersson JA, Peniche AG, Galindo CL, Boonma P, Sha J, Luna RA, Savidge TC, Chopra AK, Dann SM. New Host-Directed Therapeutics for the Treatment of Clostridioides difficile Infection. mBio. 2020 03 10; 11(2). PMID: 32156806.
      Citations:    Fields:    Translation:Animals
    18. Kline KT, Lian H, Zhong XS, Luo X, Winston JH, Cong Y, Savidge TC, Dashwood RH, Powell DW, Li Q. Neonatal Injury Increases Gut Permeability by Epigenetically Suppressing E-Cadherin in Adulthood. J Immunol. 2020 02 15; 204(4):980-989. PMID: 31889022.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    19. Spinler JK, Gonzales-Luna AJ, Raza S, Runge JK, Luna RA, Savidge TC, Garey KW. Complete Genome Sequence of Clostridioides difficile Ribotype 255 Strain Mta-79, Assembled Using Oxford Nanopore and Illumina Sequencing. Microbiol Resour Announc. 2019 Oct 17; 8(42). PMID: 31624167.
      Citations: 3     
    20. Spinner JA, Bocchini CE, Luna RA, Thapa S, Balderas MA, Denfield SW, Dreyer WJ, Nagy-Szakal D, Ihekweazu FD, Versalovic J, Savidge T, Kellermayer R. Fecal microbiota transplantation in a toddler after heart transplant was a safe and effective treatment for recurrent Clostridiodes difficile infection: A case report. Pediatr Transplant. 2020 02; 24(1):e13598. PMID: 31617299.
      Citations: 1     Fields:    Translation:Humans
    21. Sallam HS, Urvil P, Savidge TC, Chen JDZ. Ghrelin abates bacterial translocation following burn injury by improving gastric emptying. Neurogastroenterol Motil. 2020 02; 32(2):e13742. PMID: 31603615.
      Citations:    Fields:    Translation:Animals
    22. Arnold LE, Luna RA, Williams K, Chan J, Parker RA, Wu Q, Hollway JA, Jeffs A, Lu F, Coury DL, Hayes C, Savidge T. Probiotics for Gastrointestinal Symptoms and Quality of Life in Autism: A Placebo-Controlled Pilot Trial. J Child Adolesc Psychopharmacol. 2019 11; 29(9):659-669. PMID: 31478755.
      Citations: 6     Fields:    Translation:Humans
    23. Horvath TD, Ak S, Haidacher SJ, Hoch KM, Savidge TC, Haag AM. Sterilization performance comparison between an autosampler-ready microporous filter vial and a syringe-based filter. J Microbiol Methods. 2019 09; 164:105669. PMID: 31356842.
      Citations:    Fields:    Translation:CellsPHPublic Health
    24. Oezguen N, Yalcinkaya N, Kücükali CI, Dahdouli M, Hollister EB, Luna RA, Türkoglu R, Kürtüncü M, Eraksoy M, Savidge TC, Tüzün E. Microbiota stratification identifies disease-specific alterations in neuro-Behçet's disease and multiple sclerosis. Clin Exp Rheumatol. 2019 Nov-Dec; 37 Suppl 121(6):58-66. PMID: 31172918.
      Citations: 8     Fields:    Translation:Humans
    25. Hosie S, Ellis M, Swaminathan M, Ramalhosa F, Seger GO, Balasuriya GK, Gillberg C, Råstam M, Churilov L, McKeown SJ, Yalcinkaya N, Urvil P, Savidge T, Bell CA, Bodin O, Wood J, Franks AE, Bornstein JC, Hill-Yardin EL. Gastrointestinal dysfunction in patients and mice expressing the autism-associated R451C mutation in neuroligin-3. Autism Res. 2019 07; 12(7):1043-1056. PMID: 31119867.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    26. Hung LY, Boonma P, Unterweger P, Parathan P, Haag A, Luna RA, Bornstein JC, Savidge TC, Foong JPP. Neonatal Antibiotics Disrupt Motility and Enteric Neural Circuits in Mouse Colon. Cell Mol Gastroenterol Hepatol. 2019; 8(2):298-300.e6. PMID: 31022477.
      Citations: 3     Fields:    Translation:Animals
    27. Hollister EB, Oezguen N, Chumpitazi BP, Luna RA, Weidler EM, Rubio-Gonzales M, Dahdouli M, Cope JL, Mistretta TA, Raza S, Metcalf GA, Muzny DM, Gibbs RA, Petrosino JF, Heitkemper M, Savidge TC, Shulman RJ, Versalovic J. Leveraging Human Microbiome Features to Diagnose and Stratify Children with Irritable Bowel Syndrome. J Mol Diagn. 2019 05; 21(3):449-461. PMID: 31005411.
      Citations: 17     Fields:    Translation:HumansCells
    28. Endres BT, Begum K, Sun H, Walk ST, Memariani A, Lancaster C, Gonzales-Luna AJ, Dotson KM, Bassères E, Offiong C, Tupy S, Kuper K, Septimus E, Arafat R, Alam MJ, Zhao Z, Hurdle JG, Savidge TC, Garey KW. Epidemic Clostridioides difficile Ribotype 027 Lineages: Comparisons of Texas Versus Worldwide Strains. Open Forum Infect Dis. 2019 Feb; 6(2):ofz013. PMID: 30793006.
      Citations: 7     
    29. Savidge T, Sorg JA. Role of Bile in Infectious Disease: the Gall of 7a-Dehydroxylating Gut Bacteria. Cell Chem Biol. 2019 01 17; 26(1):1-3. PMID: 30658109.
      Citations:    Fields:    Translation:Cells
    30. Chen D, Li Y, Guo W, Li Y, Savidge T, Li X, Fan X. The shielding effect of metal complexes on the binding affinities of ligands to metalloproteins. Phys Chem Chem Phys. 2018 Dec 19; 21(1):205-216. PMID: 30516774.
      Citations:    Fields:    Translation:Cells
    31. Bajaj JS, Kakiyama G, Savidge T, Takei H, Kassam ZA, Fagan A, Gavis EA, Pandak WM, Nittono H, Hylemon PB, Boonma P, Haag A, Heuman DM, Fuchs M, John B, Sikaroodi M, Gillevet PM. Antibiotic-Associated Disruption of Microbiota Composition and Function in Cirrhosis Is Restored by Fecal Transplant. Hepatology. 2018 10; 68(4):1549-1558. PMID: 29665102.
      Citations: 27     Fields:    Translation:HumansCTClinical Trials
    32. Chen D, Li Y, Zhao M, Tan W, Li X, Savidge T, Guo W, Fan X. Effective lead optimization targeting the displacement of bridging receptor-ligand water molecules. Phys Chem Chem Phys. 2018 Oct 07; 20(37):24399-24407. PMID: 30221291.
      Citations: 2     Fields:    Translation:Cells
    33. Hegde S, Lin YM, Golovko G, Khanipov K, Cong Y, Savidge T, Fofanov Y, Shi XZ. Microbiota dysbiosis and its pathophysiological significance in bowel obstruction. Sci Rep. 2018 09 03; 8(1):13044. PMID: 30177854.
      Citations: 7     Fields:    Translation:AnimalsCells
    34. Peniche AG, Spinler JK, Boonma P, Savidge TC, Dann SM. Aging impairs protective host defenses against Clostridioides (Clostridium) difficile infection in mice by suppressing neutrophil and IL-22 mediated immunity. Anaerobe. 2018 Dec; 54:83-91. PMID: 30099125.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    35. Zhong XS, Winston JH, Luo X, Kline KT, Nayeem SZ, Cong Y, Savidge TC, Dashwood RH, Powell DW, Li Q. Neonatal Colonic Inflammation Epigenetically Aggravates Epithelial Inflammatory Responses to Injury in Adult Life. Cell Mol Gastroenterol Hepatol. 2018; 6(1):65-78. PMID: 29928672.
      Citations: 6     Fields:    
    36. Spinler JK, Auchtung J, Brown A, Boonma P, Oezguen N, Ross CL, Luna RA, Runge J, Versalovic J, Peniche A, Dann SM, Britton RA, Haag A, Savidge TC. Next-Generation Probiotics Targeting Clostridium difficile through Precursor-Directed Antimicrobial Biosynthesis. Infect Immun. 2017 10; 85(10). PMID: 28760934.
      Citations: 18     Fields:    Translation:HumansCells
    37. Yu H, Chen K, Sun Y, Carter M, Garey KW, Savidge TC, Devaraj S, Tessier ME, von Rosenvinge EC, Kelly CP, Pasetti MF, Feng H. Cytokines Are Markers of the Clostridium difficile-Induced Inflammatory Response and Predict Disease Severity. Clin Vaccine Immunol. 2017 Aug; 24(8). PMID: 28592627.
      Citations: 25     Fields:    Translation:HumansCells
    38. Labus JS, Hollister EB, Jacobs J, Kirbach K, Oezguen N, Gupta A, Acosta J, Luna RA, Aagaard K, Versalovic J, Savidge T, Hsiao E, Tillisch K, Mayer EA. Differences in gut microbial composition correlate with regional brain volumes in irritable bowel syndrome. Microbiome. 2017 05 01; 5(1):49. PMID: 28457228.
      Citations: 64     Fields:    Translation:HumansCells
    39. Ström J, Tham J, Månsson F, Ahl J, Savidge TC, Dann SM, Resman F. The Association between GABA-Modulators and Clostridium difficile Infection - A Matched Retrospective Case-Control Study. PLoS One. 2017; 12(1):e0169386. PMID: 28060888.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    40. Luna RA, Oezguen N, Balderas M, Venkatachalam A, Runge JK, Versalovic J, Veenstra-VanderWeele J, Anderson GM, Savidge T, Williams KC. Distinct Microbiome-Neuroimmune Signatures Correlate With Functional Abdominal Pain in Children With Autism Spectrum Disorder. Cell Mol Gastroenterol Hepatol. 2017 Mar; 3(2):218-230. PMID: 28275689.
      Citations: 54     Fields:    
    41. Spinler JK, Ross CL, Savidge TC. Probiotics as adjunctive therapy for preventing Clostridium difficile infection - What are we waiting for? Anaerobe. 2016 Oct; 41:51-57. PMID: 27180657.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    42. Ross CL, Spinler JK, Savidge TC. Structural and functional changes within the gut microbiota and susceptibility to Clostridium difficile infection. Anaerobe. 2016 Oct; 41:37-43. PMID: 27180006.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    43. Spinler JK, Brown A, Ross CL, Boonma P, Conner ME, Savidge TC. Administration of probiotic kefir to mice with Clostridium difficile infection exacerbates disease. Anaerobe. 2016 Aug; 40:54-7. PMID: 27180007.
      Citations: 6     Fields:    Translation:AnimalsCells
    44. Chen D, Oezguen N, Urvil P, Ferguson C, Dann SM, Savidge TC. Regulation of protein-ligand binding affinity by hydrogen bond pairing. Sci Adv. 2016 03; 2(3):e1501240. PMID: 27051863.
      Citations: 49     Fields:    Translation:Cells
    45. Luna RA, Savidge TC, Williams KC. The Brain-Gut-Microbiome Axis: What Role Does It Play in Autism Spectrum Disorder? Curr Dev Disord Rep. 2016 Mar; 3(1):75-81. PMID: 27398286.
      Citations: 14     
    46. Savidge TC. Epigenetic Regulation of Enteric Neurotransmission by Gut Bacteria. Front Cell Neurosci. 2015; 9:503. PMID: 26778967.
      Citations: 5     
    47. Savidge TC. Glial Orchestrated Neurodegeneration: An Important Crossroad for Neural Stem Cell Therapy to the Intestine. Cell Mol Gastroenterol Hepatol. 2016 Jan; 2(1):9-10. PMID: 28174703.
      Citations:    Fields:    
    48. Chen D, Savidge T. BIOPHYSICS. Comment on "Extreme electric fields power catalysis in the active site of ketosteroid isomerase". Science. 2015 Aug 28; 349(6251):936. PMID: 26315427.
      Citations: 3     Fields:    
    49. Yu H, Chen K, Wu J, Yang Z, Shi L, Barlow LL, Aronoff DM, Garey KW, Savidge TC, von Rosenvinge EC, Kelly CP, Feng H. Identification of toxemia in patients with Clostridium difficile infection. PLoS One. 2015; 10(4):e0124235. PMID: 25885671.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    50. MacEachern SJ, Patel BA, Keenan CM, Dicay M, Chapman K, McCafferty DM, Savidge TC, Beck PL, MacNaughton WK, Sharkey KA. Inhibiting Inducible Nitric Oxide Synthase in Enteric Glia Restores Electrogenic Ion Transport in Mice With Colitis. Gastroenterology. 2015 Aug; 149(2):445-55.e3. PMID: 25865048.
      Citations: 21     Fields:    Translation:AnimalsCells
    51. Li S, Shi L, Yang Z, Zhang Y, Perez-Cordon G, Huang T, Ramsey J, Oezguen N, Savidge TC, Feng H. Critical roles of Clostridium difficile toxin B enzymatic activities in pathogenesis. Infect Immun. 2015 Feb; 83(2):502-13. PMID: 25404023.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    52. Joffré E, von Mentzer A, Abd El Ghany M, Oezguen N, Savidge T, Dougan G, Svennerholm AM, Sjöling Å. Allele variants of enterotoxigenic Escherichia coli heat-labile toxin are globally transmitted and associated with colonization factors. J Bacteriol. 2015 Jan; 197(2):392-403. PMID: 25404692.
      Citations: 11     Fields:    
    53. Savidge TC. Importance of NO and its related compounds in enteric nervous system regulation of gut homeostasis and disease susceptibility. Curr Opin Pharmacol. 2014 Dec; 19:54-60. PMID: 25108170.
      Citations: 6     Fields:    Translation:HumansAnimals
    54. Couturier J, Hutchison AT, Medina MA, Gingaras C, Urvil P, Yu X, Nguyen C, Mahale P, Lin L, Kozinetz CA, Schmitz JE, Kimata JT, Savidge TC, Lewis DE. HIV replication in conjunction with granzyme B production by CCR5+ memory CD4 T cells: Implications for bystander cell and tissue pathologies. Virology. 2014 Aug; 462-463:175-88. PMID: 24999042.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    55. Sharkey KA, Savidge TC. Reprint of: Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract. Auton Neurosci. 2014 May; 182:70-82. PMID: 24674836.
      Citations: 5     Fields:    
    56. Mayer EA, Savidge T, Shulman RJ. Brain-gut microbiome interactions and functional bowel disorders. Gastroenterology. 2014 May; 146(6):1500-12. PMID: 24583088.
      Citations: 116     Fields:    Translation:HumansAnimalsCells
    57. Chumpitazi BP, Hollister EB, Oezguen N, Tsai CM, McMeans AR, Luna RA, Savidge TC, Versalovic J, Shulman RJ. Gut microbiota influences low fermentable substrate diet efficacy in children with irritable bowel syndrome. Gut Microbes. 2014 Mar-Apr; 5(2):165-75. PMID: 24637601.
      Citations: 33     Fields:    Translation:HumansCells
    58. Sharkey KA, Savidge TC. Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract. Auton Neurosci. 2014 Apr; 181:94-106. PMID: 24412639.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    59. Peniche AG, Savidge TC, Dann SM. Recent insights into Clostridium difficile pathogenesis. Curr Opin Infect Dis. 2013 Oct; 26(5):447-53. PMID: 23982235.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    60. Zhang Y, Shi L, Li S, Yang Z, Standley C, Yang Z, ZhuGe R, Savidge T, Wang X, Feng H. A segment of 97 amino acids within the translocation domain of Clostridium difficile toxin B is essential for toxicity. PLoS One. 2013; 8(3):e58634. PMID: 23484044.
      Citations: 17     Fields:    Translation:AnimalsCells
    61. Juneau C, Mendias EN, Wagal N, Loeffelholz M, Savidge T, Croisant S, Dann S. Community-Acquired Clostridium Difficile Infection: Awareness and Clinical Implications. J Nurse Pract. 2013 Jan; 9(1):1-6. PMID: 23814528.
      Citations: 5     
    62. Wang H, Sun X, Zhang Y, Li S, Chen K, Shi L, Nie W, Kumar R, Tzipori S, Wang J, Savidge T, Feng H. A chimeric toxin vaccine protects against primary and recurrent Clostridium difficile infection. Infect Immun. 2012 Aug; 80(8):2678-88. PMID: 22615245.
      Citations: 46     Fields:    Translation:AnimalsCells
    63. Medina MA, Couturier J, Feske ML, Mahne AE, Turner M, Yu X, Kozinetz CA, Orozco AF, Hutchison AT, Savidge TC, Rodgers JR, Lewis DE. Granzyme B- and Fas ligand-mediated cytotoxic function induced by mitogenic CD28 stimulation of human memory CD4+ T cells. J Leukoc Biol. 2012 May; 91(5):759-71. PMID: 22416257.
      Citations: 7     Fields:    Translation:HumansCells
    64. Oezguen N, Power TD, Urvil P, Feng H, Pothoulakis C, Stamler JS, Braun W, Savidge TC. Clostridial toxins: sensing a target in a hostile gut environment. Gut Microbes. 2012 Jan-Feb; 3(1):35-41. PMID: 22356854.
      Citations: 2     Fields:    Translation:HumansCells
    65. Savidge TC, Urvil P, Oezguen N, Ali K, Choudhury A, Acharya V, Pinchuk I, Torres AG, English RD, Wiktorowicz JE, Loeffelholz M, Kumar R, Shi L, Nie W, Braun W, Herman B, Hausladen A, Feng H, Stamler JS, Pothoulakis C. Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins. Nat Med. 2011 Aug 21; 17(9):1136-41. PMID: 21857653.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    66. Savidge TC. Glia and NO nicotine: a perfect harmony for secretory control. J Physiol. 2011 Aug 01; 589(Pt 15):3685-6. PMID: 21807608.
      Citations: 3     Fields:    Translation:AnimalsCells
    67. Wiktorowicz JE, Stafford S, Rea H, Urvil P, Soman K, Kurosky A, Perez-Polo JR, Savidge TC. Quantification of cysteinyl S-nitrosylation by fluorescence in unbiased proteomic studies. Biochemistry. 2011 Jun 28; 50(25):5601-14. PMID: 21615140.
      Citations: 16     Fields:    Translation:AnimalsCells
    68. Savidge TC. S-nitrosothiol signals in the enteric nervous system: lessons learnt from big brother. Front Neurosci. 2011; 5:31. PMID: 21441985.
      Citations: 9     
    69. Van Landeghem L, Chevalier J, Mahé MM, Wedel T, Urvil P, Derkinderen P, Savidge T, Neunlist M. Enteric glia promote intestinal mucosal healing via activation of focal adhesion kinase and release of proEGF. Am J Physiol Gastrointest Liver Physiol. 2011 Jun; 300(6):G976-87. PMID: 21350188.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    70. Flamant M, Aubert P, Rolli-Derkinderen M, Bourreille A, Neunlist MR, Mahé MM, Meurette G, Marteyn B, Savidge T, Galmiche JP, Sansonetti PJ, Neunlist M. Enteric glia protect against Shigella flexneri invasion in intestinal epithelial cells: a role for S-nitrosoglutathione. Gut. 2011 Apr; 60(4):473-84. PMID: 21139062.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    71. Chaniotou Z, Giannogonas P, Theoharis S, Teli T, Gay J, Savidge T, Koutmani Y, Brugni J, Kokkotou E, Pothoulakis C, Karalis KP. Corticotropin-releasing factor regulates TLR4 expression in the colon and protects mice from colitis. Gastroenterology. 2010 Dec; 139(6):2083-92. PMID: 20732324.
      Citations: 19     Fields:    Translation:Animals
    72. Sun X, Savidge T, Feng H. The enterotoxicity of Clostridium difficile toxins. Toxins (Basel). 2010 07; 2(7):1848-80. PMID: 22069662.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    73. Savidge TC. MIND the gap: an astroglial perspective on barrier regulation. Neuron Glia Biol. 2007 Aug; 3(3):191-7. PMID: 18634610.
      Citations: 3     Fields:    
    74. Hoogerwerf WA, Hellmich HL, Cornélissen G, Halberg F, Shahinian VB, Bostwick J, Savidge TC, Cassone VM. Clock gene expression in the murine gastrointestinal tract: endogenous rhythmicity and effects of a feeding regimen. Gastroenterology. 2007 Oct; 133(4):1250-60. PMID: 17919497.
      Citations: 86     Fields:    Translation:AnimalsCells
    75. Savidge TC, Sofroniew MV, Neunlist M. Starring roles for astroglia in barrier pathologies of gut and brain. Lab Invest. 2007 Aug; 87(8):731-6. PMID: 17607301.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    76. Moss AC, Anton P, Savidge T, Newman P, Cheifetz AS, Gay J, Paraschos S, Winter MW, Moyer MP, Karalis K, Kokkotou E, Pothoulakis C. Urocortin II mediates pro-inflammatory effects in human colonocytes via corticotropin-releasing hormone receptor 2alpha. Gut. 2007 Sep; 56(9):1210-7. PMID: 17412781.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    77. Savidge TC, Newman P, Pothoulakis C, Ruhl A, Neunlist M, Bourreille A, Hurst R, Sofroniew MV. Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione. Gastroenterology. 2007 Apr; 132(4):1344-58. PMID: 17408650.
      Citations: 124     Fields:    Translation:HumansAnimalsCells
    78. Savidge TC, Newman PG, Pan WH, Weng MQ, Shi HN, McCormick BA, Quaroni A, Walker WA. Lipopolysaccharide-induced human enterocyte tolerance to cytokine-mediated interleukin-8 production may occur independently of TLR-4/MD-2 signaling. Pediatr Res. 2006 Jan; 59(1):89-95. PMID: 16326999.
      Citations: 12     Fields:    Translation:HumansCells
    79. Kim H, Rhee SH, Kokkotou E, Na X, Savidge T, Moyer MP, Pothoulakis C, LaMont JT. Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK. J Biol Chem. 2005 Jun 03; 280(22):21237-45. PMID: 15767259.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    80. Mrsny RJ, Gewirtz AT, Siccardi D, Savidge T, Hurley BP, Madara JL, McCormick BA. Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7421-6. PMID: 15123795.
      Citations: 82     Fields:    Translation:HumansCells
    81. Claud EC, Lu L, Anton PM, Savidge T, Walker WA, Cherayil BJ. Developmentally regulated IkappaB expression in intestinal epithelium and susceptibility to flagellin-induced inflammation. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7404-8. PMID: 15123821.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    82. Savidge TC, Pan WH, Newman P, O'brien M, Anton PM, Pothoulakis C. Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine. Gastroenterology. 2003 Aug; 125(2):413-20. PMID: 12891543.
      Citations: 92     Fields:    Translation:HumansAnimalsCells
    83. Lu L, Baldeon ME, Savidge T, Pothoulakis C, Walker WA. Development of microbial-human enterocyte interaction: cholera toxin. Pediatr Res. 2003 Aug; 54(2):212-8. PMID: 12736381.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    84. Buisine MP, Aubert JP, Walker WA, Savidge TC. Developmental patterns of mucin gene expression in human fetal small intestinal xenografts maintained in severe-combined immunodeficient mice. Pediatr Res. 2003 Jun; 53(6):898-904. PMID: 12646731.
      Citations: 2     Fields:    Translation:HumansAnimals
    85. Claud EC, Savidge T, Walker WA. Modulation of human intestinal epithelial cell IL-8 secretion by human milk factors. Pediatr Res. 2003 Mar; 53(3):419-25. PMID: 12595589.
      Citations: 44     Fields:    Translation:HumansCells
    86. Cabarrocas J, Savidge TC, Liblau RS. Role of enteric glial cells in inflammatory bowel disease. Glia. 2003 Jan; 41(1):81-93. PMID: 12465048.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    87. Dai D, Nanthakumar NN, Savidge TC, Newburg DS, Walker WA. Region-specific ontogeny of alpha-2,6-sialyltransferase during normal and cortisone-induced maturation in mouse intestine. Am J Physiol Gastrointest Liver Physiol. 2002 Mar; 282(3):G480-90. PMID: 11841998.
      Citations: 11     Fields:    Translation:AnimalsCells
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