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Theodore G. Wensel

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry & Molecular Biology
DivisionBiochemistry & Molecular Biology
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    Other Positions
    TitleChair
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Biochemistry & Molecular Biology
    DivisionBiochemistry & Molecular Biology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Ophthalmology
    DivisionOphthalmology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pharmacology and Chemical Biology
    DivisionPharmacology


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    Collapse Biography 
    Collapse awards and honors
    2005Barbara and Corbin J. Robertson Jr. Presidential Award for Excellence in Education , Baylor College of Medicine
    2013Proctor Medal, Association for Research in Vision and Ophthalmology
    2013Alcon Research Award, Alcon Research Institute

    Collapse Overview 
    Collapse overview
    Theodore (Ted) Wensel is Chair of the Verna and Marrs McLean Department of Biochemistry and Molecular Biology. In 2012, it ranked 11th among medical school Biochemistry departments nationwide in NIH funding, according to the Blue Ridge Institute for Medical Research.
    The Wensel lab studies molecular mechanisms of intracellular signal transduction, primarily in the nervous system, and new approaches to understanding and developing therapies for diseases involving defects in signal transduction and neurodegeneration in sensory systems. Our approaches range from using x-ray crystallography, cryo-electron microscopy mutagenesis, and time resolved luminescence energy transfer to understand the structural basis for signal transduction at the molecular and atomic level, to extensive use and development of genetically engineered animal models to understand the impact of molecular defects at the level of intact animals. Particular areas of interest and expertise include:
    Visual transduction in the vertebrate retina
    G protein pathways and proteins that regulate them in the retina and the brain
    RGS proteins: GAPs for heterotrimeric G proteins
    Biomembranes
    Ocular Proteomics
    Gene repair in neurons
    Time-resolved fluorescence and luminescence
    Electron and x-ray crystallography
    Cryo-electron tomography
    Gene engineering in mice and frogs
    TRP Channels

    Theodore (Ted) Wensel is Chair of the Verna and Marrs McLean Department of Biochemistry and Molecular Biology. In 2013, it ranked 10th among medical school Biochemistry departments nationwide in NIH funding, according to the Blue Ridge Institute for Medical Research.
    The Wensel lab studies molecular mechanisms of intracellular signal transduction, primarily in the nervous system, and new approaches to understanding and developing therapies for diseases involving defects in signal transduction and neurodegeneration in sensory systems. Our approaches range from using x-ray crystallography, cryo-electron microscopy mutagenesis, and time resolved luminescence energy transfer to understand the structural basis for signal transduction at the molecular and atomic level, to extensive use and development of genetically engineered animal models to understand the impact of molecular defects at the level of intact animals. Particular areas of interest and expertise include:
    Visual transduction in the vertebrate retina
    G protein pathways and proteins that regulate them in the retina and the brain
    RGS proteins: GAPs for heterotrimeric G proteins
    Biomembranes
    Ocular Proteomics
    Gene repair in neurons
    Time-resolved fluorescence and luminescence
    Electron and x-ray crystallography
    Cryo-electron tomography
    Gene engineering in mice and frogs
    TRP Channels

    Collapse Research 
    Collapse research activities and funding
    F32EY005815     (WENSEL, THEODORE G)Jun 24, 1985
    NIH/NEI
    PROTEIN INTERACTIONS IN VISUAL TRANSDUCTION
    Role: Principal Investigator

    T32GM008280     (WENSEL, THEODORE G.)Sep 30, 1988 - Jun 30, 2024
    NIH/NIGMS
    Houston Area Molecular Biophysics Program
    Role: Principal Investigator

    R01EY007981     (WENSEL, THEODORE G.)Aug 1, 1989 - Feb 28, 2017
    NIH/NEI
    Trasnducin Interactions with Photoreceptor Membranes
    Role: Principal Investigator

    U13EY010618     (WENSEL, THEODORE G)Apr 1, 1994 - Jun 30, 2014
    NIH/NEI
    Course on Fundamental Issues in Vision Research
    Role: Principal Investigator

    R01EY011900     (WENSEL, THEODORE G)Jul 1, 1998 - Jun 30, 2012
    NIH/NEI
    RGS Protein Function in Mammalian Retina
    Role: Principal Investigator

    R01DA015189     (WENSEL, THEODORE G)Jul 15, 2002 - Apr 30, 2007
    NIH/NIDA
    RGS Domain Function in Mammalian Brain
    Role: Principal Investigator

    U13EY021709     (WENSEL, THEODORE G)May 1, 2011 - Apr 30, 2012
    NIH/NEI
    FASEB SRC on Biology and Chemistry of Vision
    Role: Principal Investigator

    R01GM097207     (WENSEL, THEODORE G.)Aug 1, 2012 - May 31, 2021
    NIH/NIGMS
    EXPLORING STRUCTURE AND SEQUENCE SPACES OF G PROTEIN-COUPLED RECEPTOR SIGNALING
    Role: Co-Principal Investigator

    R01EY025218     (WENSEL, THEODORE G.)Dec 1, 2015 - Nov 30, 2019
    NIH/NEI
    Light regulation of retinal phosphoinositides
    Role: Principal Investigator

    R01EY026545     (WENSEL, THEODORE G.)Apr 1, 2016 - Mar 31, 2020
    NIH/NEI
    Cilium-Associated Structures in Rod Cells
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Robichaux MA, Potter VL, Zhang Z, He F, Liu J, Schmid MF, Wensel TG. Defining the layers of a sensory cilium with STORM and cryoelectron nanoscopy. Proc Natl Acad Sci U S A. 2019 Nov 05. PMID: 31690665.
      View in: PubMed
    2. Terrón-Díaz ME, Wright SJ, Agosto MA, Lichtarge O, Wensel TG. Residues and residue pairs of evolutionary importance differentially direct signaling bias of D2 dopamine receptors. J Biol Chem. 2019 Nov 01. PMID: 31676688.
      View in: PubMed
    3. Tang J, Robichaux MA, Wu KL, Pei J, Nguyen NT, Zhou Y, Wensel TG, Xiao H. Single-Atom Fluorescence Switch: A General Approach toward Visible-Light-Activated Dyes for Biological Imaging. J Am Chem Soc. 2019 Sep 18; 141(37):14699-14706. PMID: 31450884.
      View in: PubMed
    4. He F, Nichols RM, Kailasam L, Wensel TG, Agosto MA. Critical Role for Phosphatidylinositol-3 Kinase Vps34/PIK3C3 in ON-Bipolar Cells. Invest Ophthalmol Vis Sci. 2019 Jul 01; 60(8):2861-2874. PMID: 31260037.
      View in: PubMed
    5. Dosey TL, Wang Z, Fan G, Zhang Z, Serysheva II, Chiu W, Wensel TG. Structures of TRPV2 in distinct conformations provide insight into role of the pore turret. Nat Struct Mol Biol. 2019 Jan; 26(1):40-49. PMID: 30598551.
      View in: PubMed
    6. Agosto MA, Anastassov IA, Robichaux MA, Wensel TG. A Large Endoplasmic Reticulum-Resident Pool of TRPM1 in Retinal ON-Bipolar Cells. eNeuro. 2018 May-Jun; 5(3). PMID: 30027108.
      View in: PubMed
    7. Dharmat R, Eblimit A, Robichaux MA, Zhang Z, Nguyen TT, Jung SY, He F, Jain A, Li Y, Qin J, Overbeek P, Roepman R, Mardon G, Wensel TG, Chen R. SPATA7 maintains a novel photoreceptor-specific zone in the distal connecting cilium. J Cell Biol. 2018 08 06; 217(8):2851-2865. PMID: 29899041.
      View in: PubMed
    8. Yu B, Egbejimi A, Dharmat R, Xu P, Zhao Z, Long B, Miao H, Chen R, Wensel TG, Cai J, Chen Y. Phagocytosed photoreceptor outer segments activate mTORC1 in the retinal pigment epithelium. Sci Signal. 2018 05 29; 11(532). PMID: 29844054.
      View in: PubMed
    9. Agosto MA, Anastassov IA, Wensel TG. Differential epitope masking reveals synapse-specific complexes of TRPM1. Vis Neurosci. 2018 01; 35:E001. PMID: 29370879.
      View in: PubMed
    10. Tse DY, Kim SJ, Chung I, He F, Wensel TG, Wu SM. The ocular toxicity and pharmacokinetics of simvastatin following intravitreal injection in mice. Int J Ophthalmol. 2017; 10(9):1361-1369. PMID: 28944193.
      View in: PubMed
    11. Galaz-Montoya M, Wright SJ, Rodriguez GJ, Lichtarge O, Wensel TG. ß2-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway. J Biol Chem. 2017 06 16; 292(24):9967-9974. PMID: 28442571.
      View in: PubMed
    12. Wensel TG, Zhang Z, Anastassov IA, Gilliam JC, He F, Schmid MF, Robichaux MA. Structural and molecular bases of rod photoreceptor morphogenesis and disease. Prog Retin Eye Res. 2016 11; 55:32-51. PMID: 27352937.
      View in: PubMed
    13. He F, Agosto MA, Anastassov IA, Tse DY, Wu SM, Wensel TG. Phosphatidylinositol-3-phosphate is light-regulated and essential for survival in retinal rods. Sci Rep. 2016 06 01; 6:26978. PMID: 27245220.
      View in: PubMed
    14. Sung YM, Wilkins AD, Rodriguez GJ, Wensel TG, Lichtarge O. Intramolecular allosteric communication in dopamine D2 receptor revealed by evolutionary amino acid covariation. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):3539-44. PMID: 26979958.
      View in: PubMed
    15. Zhao L, Chen Y, Bajaj AO, Eblimit A, Xu M, Soens ZT, Wang F, Ge Z, Jung SY, He F, Li Y, Wensel TG, Qin J, Chen R. Integrative subcellular proteomic analysis allows accurate prediction of human disease-causing genes. Genome Res. 2016 05; 26(5):660-9. PMID: 26912414.
      View in: PubMed
    16. Roman-Sanchez R, Wensel TG, Wilson JH. Nonsense mutations in the rhodopsin gene that give rise to mild phenotypes trigger mRNA degradation in human cells by nonsense-mediated decay. Exp Eye Res. 2016 04; 145:444-449. PMID: 26416182.
      View in: PubMed
    17. Zhang Z, He F, Constantine R, Baker ML, Baehr W, Schmid MF, Wensel TG, Agosto MA. Domain organization and conformational plasticity of the G protein effector, PDE6. J Biol Chem. 2015 Jul 10; 290(28):17131-2. PMID: 26163476.
      View in: PubMed
    18. Wang S, Tan KL, Agosto MA, Xiong B, Yamamoto S, Sandoval H, Jaiswal M, Bayat V, Zhang K, Charng WL, David G, Duraine L, Venkatachalam K, Wensel TG, Bellen HJ. Correction: the retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration. PLoS Biol. 2015 May; 13(5):e1002170. PMID: 26020534.
      View in: PubMed
    19. Zhang Z, He F, Constantine R, Baker ML, Baehr W, Schmid MF, Wensel TG, Agosto MA. Domain organization and conformational plasticity of the G protein effector, PDE6. J Biol Chem. 2015 May 15; 290(20):12833-43. PMID: 25809480.
      View in: PubMed
    20. Wensel TG, Gilliam JC. Three-dimensional architecture of murine rod cilium revealed by cryo-EM. Methods Mol Biol. 2015; 1271:267-92. PMID: 25697530.
      View in: PubMed
    21. Kang HJ, Wilkins AD, Lichtarge O, Wensel TG. Determinants of endogenous ligand specificity divergence among metabotropic glutamate receptors. J Biol Chem. 2015 Jan 30; 290(5):2870-8. PMID: 25519912.
      View in: PubMed
    22. Sandoval IM, Price BA, Gross AK, Chan F, Sammons JD, Wilson JH, Wensel TG. Abrupt onset of mutations in a developmentally regulated gene during terminal differentiation of post-mitotic photoreceptor neurons in mice. PLoS One. 2014; 9(9):e108135. PMID: 25264759.
      View in: PubMed
    23. Kang HJ, Menlove K, Ma J, Wilkins A, Lichtarge O, Wensel TG. Selectivity and evolutionary divergence of metabotropic glutamate receptors for endogenous ligands and G proteins coupled to phospholipase C or TRP channels. J Biol Chem. 2014 Oct 24; 289(43):29961-74. PMID: 25193666.
      View in: PubMed
    24. Agosto MA, Zhang Z, He F, Anastassov IA, Wright SJ, McGehee J, Wensel TG. Oligomeric state of purified transient receptor potential melastatin-1 (TRPM1), a protein essential for dim light vision. J Biol Chem. 2014 Sep 26; 289(39):27019-33. PMID: 25112866.
      View in: PubMed
    25. Wang S, Tan KL, Agosto MA, Xiong B, Yamamoto S, Sandoval H, Jaiswal M, Bayat V, Zhang K, Charng WL, David G, Duraine L, Venkatachalam K, Wensel TG, Bellen HJ. The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration. PLoS Biol. 2014 Apr; 12(4):e1001847. PMID: 24781186.
      View in: PubMed
    26. Wang S, Tan KL, Agosto MA, Xiong B, Yamamoto S, Sandoval H, Jaiswal M, Bayat V, Zhang K, Charng WL, David G, Duraine L, Venkatachalam K, Wensel TG, Bellen HJ;. Research Article. The retromer complex is required for rhodopsin recycling and its loss leads to photoreceptor degeneration. 2014; 12(4):e1001847.
    27. Arshavsky VY, Wensel TG. Timing is everything: GTPase regulation in phototransduction. Invest Ophthalmol Vis Sci. 2013 Nov 21; 54(12):7725-33. PMID: 24265205.
      View in: PubMed
    28. Gilliam JC, Chang JT, Sandoval IM, Zhang Y, Li T, Pittler SJ, Chiu W, Wensel TG. Three-dimensional architecture of the rod sensory cilium and its disruption in retinal neurodegeneration. Cell. 2012 Nov 21; 151(5):1029-41. PMID: 23178122.
      View in: PubMed
    29. Price BA, Sandoval IM, Chan F, Nichols R, Roman-Sanchez R, Wensel TG, Wilson JH. Rhodopsin gene expression determines rod outer segment size and rod cell resistance to a dominant-negative neurodegeneration mutant. PLoS One. 2012; 7(11):e49889. PMID: 23185477.
      View in: PubMed
    30. Price BA, Sandoval IM, Chan F, Simons DL, Wu SM, Wensel TG, Wilson JH. Mislocalization and degradation of human P23H-rhodopsin-GFP in a knockin mouse model of retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2011 Dec 28; 52(13):9728-36. PMID: 22110080.
      View in: PubMed
    31. Gilliam JC, Wensel TG. TRP channel gene expression in the mouse retina. Vision Res. 2011 Dec 08; 51(23-24):2440-52. PMID: 22037305.
      View in: PubMed
    32. Chan F, Hauswirth WW, Wensel TG, Wilson JH. Efficient mutagenesis of the rhodopsin gene in rod photoreceptor neurons in mice. Nucleic Acids Res. 2011 Aug; 39(14):5955-66. PMID: 21478169.
      View in: PubMed
    33. Baehr W, Wensel T, Hageman G, Wu S, Zack D. Retinal ganglion cells: development, function, and disease. Vision Res. 2011 Jan 28; 51(2):223. PMID: 21251506.
      View in: PubMed
    34. Moiseenkova-Bell V, Wensel TG. Functional and structural studies of TRP channels heterologously expressed in budding yeast. Adv Exp Med Biol. 2011; 704:25-40. PMID: 21290288.
      View in: PubMed
    35. Mojumder DK, Concepcion FA, Patel SK, Barkmeier AJ, Carvounis PE, Wilson JH, Holz ER, Wensel TG. Evaluating retinal toxicity of intravitreal caspofungin in the mouse eye. Invest Ophthalmol Vis Sci. 2010 Nov; 51(11):5796-803. PMID: 20505203.
      View in: PubMed
    36. Rodriguez GJ, Yao R, Lichtarge O, Wensel TG. Evolution-guided discovery and recoding of allosteric pathway specificity determinants in psychoactive bioamine receptors. Proc Natl Acad Sci U S A. 2010 Apr 27; 107(17):7787-92. PMID: 20385837.
      View in: PubMed
    37. Budzynski E, Gross AK, McAlear SD, Peachey NS, Shukla M, He F, Edwards M, Won J, Hicks WL, Wensel TG, Naggert JK, Nishina PM. Mutations of the opsin gene (Y102H and I307N) lead to light-induced degeneration of photoreceptors and constitutive activation of phototransduction in mice. J Biol Chem. 2010 May 07; 285(19):14521-33. PMID: 20207741.
      View in: PubMed
    38. Jeffrey BG, Morgans CW, Puthussery T, Wensel TG, Burke NS, Brown RL, Duvoisin RM. R9AP stabilizes RGS11-G beta5 and accelerates the early light response of ON-bipolar cells. Vis Neurosci. 2010 Mar; 27(1-2):9-17. PMID: 20100392.
      View in: PubMed
    39. Mancuso JJ, Qian Y, Long C, Wu GY, Wensel TG. Distribution of RGS9-2 in neurons of the mouse striatum. J Neurochem. 2010 Feb; 112(3):651-61. PMID: 19912469.
      View in: PubMed
    40. Yao CK, Lin YQ, Ly CV, Ohyama T, Haueter CM, Moiseenkova-Bell VY, Wensel TG, Bellen HJ. A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis. Cell. 2009 Sep 04; 138(5):947-60. PMID: 19737521.
      View in: PubMed
    41. Mojumder DK, Wensel TG. Topical mydriatics affect light-evoked retinal responses in anesthetized mice. Invest Ophthalmol Vis Sci. 2010 Jan; 51(1):567-76. PMID: 19661232.
      View in: PubMed
    42. Mojumder DK, Qian Y, Wensel TG. Two R7 regulator of G-protein signaling proteins shape retinal bipolar cell signaling. J Neurosci. 2009 Jun 17; 29(24):7753-65. PMID: 19535587.
      View in: PubMed
    43. Mancuso JJ, Larson AM, Wensel TG, Saggau P. Multiphoton adaptation of a commercial low-cost confocal microscope for live tissue imaging. J Biomed Opt. 2009 May-Jun; 14(3):034048. PMID: 19566340.
      View in: PubMed
    44. Moiseenkova-Bell VY, Wensel TG. Hot on the trail of TRP channel structure. J Gen Physiol. 2009 Mar; 133(3):239-44. PMID: 19237588.
      View in: PubMed
    45. Sakamoto K, McCluskey M, Wensel TG, Naggert JK, Nishina PM. New mouse models for recessive retinitis pigmentosa caused by mutations in the Pde6a gene. Hum Mol Genet. 2009 Jan 01; 18(1):178-92. PMID: 18849587.
      View in: PubMed
    46. Mojumder DK, Wensel TG, Frishman LJ. Subcellular compartmentalization of two calcium binding proteins, calretinin and calbindin-28 kDa, in ganglion and amacrine cells of the rat retina. Mol Vis. 2008 Aug 31; 14:1600-13. PMID: 18769561.
      View in: PubMed
    47. Wang Q, Zhang X, Zhang L, He F, Zhang G, Jamrich M, Wensel TG. Activation-dependent hindrance of photoreceptor G protein diffusion by lipid microdomains. J Biol Chem. 2008 Oct 31; 283(44):30015-24. PMID: 18713731.
      View in: PubMed
    48. Moiseenkova-Bell VY, Stanciu LA, Serysheva II, Tobe BJ, Wensel TG. Structure of TRPV1 channel revealed by electron cryomicroscopy. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7451-5. PMID: 18490661.
      View in: PubMed
    49. Benfield AP, Macleod MC, Liu Y, Wu Q, Wensel TG, Vasquez KM. Targeted generation of DNA strand breaks using pyrene-conjugated triplex-forming oligonucleotides. Biochemistry. 2008 Jun 10; 47(23):6279-88. PMID: 18473480.
      View in: PubMed
    50. Wensel TG. Signal transducing membrane complexes of photoreceptor outer segments. Vision Res. 2008 Sep; 48(20):2052-61. PMID: 18456304.
      View in: PubMed
    51. Jedema HP, Gold SJ, Gonzalez-Burgos G, Sved AF, Tobe BJ, Wensel T, Grace AA. Chronic cold exposure increases RGS7 expression and decreases alpha(2)-autoreceptor-mediated inhibition of noradrenergic locus coeruleus neurons. Eur J Neurosci. 2008 May; 27(9):2433-43. PMID: 18461718.
      View in: PubMed
    52. Abd-El-Barr MM, Albini TA, Carvounis PE, He F, Manzano RP, Chevez-Barrios P, Wensel TG, Wu SM, Holz ER. Safety and pharmokinetics of triamcinolone hexacetonide in rabbit eyes. J Ocul Pharmacol Ther. 2008 Apr; 24(2):197-205. PMID: 18355133.
      View in: PubMed
    53. Morgans CW, Wensel TG, Brown RL, Perez-Leon JA, Bearnot B, Duvoisin RM. Gbeta5-RGS complexes co-localize with mGluR6 in retinal ON-bipolar cells. Eur J Neurosci. 2007 Nov; 26(10):2899-905. PMID: 18001285.
      View in: PubMed
    54. Khajavi M, Shiga K, Wiszniewski W, He F, Shaw CA, Yan J, Wensel TG, Snipes GJ, Lupski JR. Oral curcumin mitigates the clinical and neuropathologic phenotype of the Trembler-J mouse: a potential therapy for inherited neuropathy. Am J Hum Genet. 2007 Sep; 81(3):438-53. PMID: 17701891.
      View in: PubMed
    55. Marc RE, Jones BW, Anderson JR, Kinard K, Marshak DW, Wilson JH, Wensel T, Lucas RJ. Neural reprogramming in retinal degeneration. Invest Ophthalmol Vis Sci. 2007 Jul; 48(7):3364-71. PMID: 17591910.
      View in: PubMed
    56. Song JH, Song H, Wensel TG, Sokolov M, Martemyanov KA. Localization and differential interaction of R7 RGS proteins with their membrane anchors R7BP and R9AP in neurons of vertebrate retina. Mol Cell Neurosci. 2007 Jun; 35(2):311-9. PMID: 17442586.
      View in: PubMed
    57. Zhang X, Wensel TG, Yuan C. Tokay gecko photoreceptors achieve rod-like physiology with cone-like proteins. Photochem Photobiol. 2006 Nov-Dec; 82(6):1452-60. PMID: 16553462.
      View in: PubMed
    58. Gross AK, Decker G, Chan F, Sandoval IM, Wilson JH, Wensel TG. Defective development of photoreceptor membranes in a mouse model of recessive retinal degeneration. Vision Res. 2006 Dec; 46(27):4510-8. PMID: 16979686.
      View in: PubMed
    59. Krispel CM, Chen D, Melling N, Chen YJ, Martemyanov KA, Quillinan N, Arshavsky VY, Wensel TG, Chen CK, Burns ME. RGS expression rate-limits recovery of rod photoresponses. Neuron. 2006 Aug 17; 51(4):409-16. PMID: 16908407.
      View in: PubMed
    60. Meltzer RH, Lurtz MM, Wensel TG, Pedersen SE. Nicotinic acetylcholine receptor channel electrostatics determined by diffusion-enhanced luminescence energy transfer. Biophys J. 2006 Aug 15; 91(4):1315-24. PMID: 16751249.
      View in: PubMed
    61. Meltzer RH, Thompson E, Soman KV, Song XZ, Ebalunode JO, Wensel TG, Briggs JM, Pedersen SE. Electrostatic steering at acetylcholine binding sites. Biophys J. 2006 Aug 15; 91(4):1302-14. PMID: 16751247.
      View in: PubMed
    62. Iyer MN, He F, Wensel TG, Mieler WF, Benz MS, Holz ER. Clearance of intravitreal moxifloxacin. Invest Ophthalmol Vis Sci. 2006 Jan; 47(1):317-9. PMID: 16384979.
      View in: PubMed
    63. Wensel TG, Gross AK, Chan F, Sykoudis K, Wilson JH. Rhodopsin-EGFP knock-ins for imaging quantal gene alterations. Vision Res. 2005 Dec; 45(28):3445-53. PMID: 16139321.
      View in: PubMed
    64. Wiszniewski W, Zaremba CM, Yatsenko AN, Jamrich M, Wensel TG, Lewis RA, Lupski JR. ABCA4 mutations causing mislocalization are found frequently in patients with severe retinal dystrophies. Hum Mol Genet. 2005 Oct 01; 14(19):2769-78. PMID: 16103129.
      View in: PubMed
    65. Iyer MN, He F, Wensel TG, Mieler WF, Benz MS, Holz ER. Intravitreal clearance of moxifloxacin. Trans Am Ophthalmol Soc. 2005; 103:76-81; discussion 81-3. PMID: 17057790.
      View in: PubMed
    66. Wensel TG, He F, Malinski JA. Purification, reconstitution on lipid vesicles, and assays of PDE6 and its activator G protein, transducin. Methods Mol Biol. 2005; 307:289-313. PMID: 15988071.
      View in: PubMed
    67. Chan F, Bradley A, Wensel TG, Wilson JH. Knock-in human rhodopsin-GFP fusions as mouse models for human disease and targets for gene therapy. Proc Natl Acad Sci U S A. 2004 Jun 15; 101(24):9109-14. PMID: 15184660.
      View in: PubMed
    68. Zhang Z, Melia TJ, He F, Yuan C, McGough A, Schmid MF, Wensel TG. How a G protein binds a membrane. J Biol Chem. 2004 Aug 06; 279(32):33937-45. PMID: 15173184.
      View in: PubMed
    69. Hu G, Wensel TG. Characterization of R9AP, a membrane anchor for the photoreceptor GTPase-accelerating protein, RGS9-1. Methods Enzymol. 2004; 390:178-96. PMID: 15488178.
      View in: PubMed
    70. He F, Mao M, Wensel TG. Enhancement of phototransduction g protein-effector interactions by phosphoinositides. J Biol Chem. 2004 Mar 05; 279(10):8986-90. PMID: 14699118.
      View in: PubMed
    71. Madabushi S, Gross AK, Philippi A, Meng EC, Wensel TG, Lichtarge O. Evolutionary trace of G protein-coupled receptors reveals clusters of residues that determine global and class-specific functions. J Biol Chem. 2004 Feb 27; 279(9):8126-32. PMID: 14660595.
      View in: PubMed
    72. Wilson JH, Wensel TG. The nature of dominant mutations of rhodopsin and implications for gene therapy. Mol Neurobiol. 2003 Oct; 28(2):149-58. PMID: 14576453.
      View in: PubMed
    73. Zhang L, El-Hodiri HM, Ma HF, Zhang X, Servetnick M, Wensel TG, Jamrich M. Targeted expression of the dominant-negative FGFR4a in the eye using Xrx1A regulatory sequences interferes with normal retinal development. Development. 2003 Sep; 130(17):4177-86. PMID: 12874136.
      View in: PubMed
    74. Burns ME, Wensel TG. From molecules to behavior: new clues for RGS function in the striatum. Neuron. 2003 Jun 19; 38(6):853-6. PMID: 12818171.
      View in: PubMed
    75. Chen CK, Eversole-Cire P, Zhang H, Mancino V, Chen YJ, He W, Wensel TG, Simon MI. Instability of GGL domain-containing RGS proteins in mice lacking the G protein beta-subunit Gbeta5. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6604-9. PMID: 12738888.
      View in: PubMed
    76. Kennedy MJ, Sowa ME, Wensel TG, Hurley JB. Acceleration of key reactions as a strategy to elucidate the rate-limiting chemistry underlying phototransduction inactivation. Invest Ophthalmol Vis Sci. 2003 Mar; 44(3):1016-22. PMID: 12601023.
      View in: PubMed
    77. Zhang X, Wensel TG, Kraft TW. GTPase regulators and photoresponses in cones of the eastern chipmunk. J Neurosci. 2003 Feb 15; 23(4):1287-97. PMID: 12598617.
      View in: PubMed
    78. Hu G, Zhang Z, Wensel TG. Activation of RGS9-1GTPase acceleration by its membrane anchor, R9AP. J Biol Chem. 2003 Apr 18; 278(16):14550-4. PMID: 12560335.
      View in: PubMed
    79. Sokal I, Hu G, Liang Y, Mao M, Wensel TG, Palczewski K. Identification of protein kinase C isozymes responsible for the phosphorylation of photoreceptor-specific RGS9-1 at Ser475. J Biol Chem. 2003 Mar 07; 278(10):8316-25. PMID: 12499365.
      View in: PubMed
    80. Hu G, Wensel TG. R9AP, a membrane anchor for the photoreceptor GTPase accelerating protein, RGS9-1. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):9755-60. PMID: 12119397.
      View in: PubMed
    81. Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, Barker SA, He W, Wensel TG, Otero G, Brown G, Copeland NG, Jenkins NA, Wilkie TM. Evolution of the regulators of G-protein signaling multigene family in mouse and human. Genomics. 2002 Feb; 79(2):177-85. PMID: 11829488.
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    82. Imanishi Y, Li N, Sokal I, Sowa ME, Lichtarge O, Wensel TG, Saperstein DA, Baehr W, Palczewski K. Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man. Eur J Neurosci. 2002 Jan; 15(1):63-78. PMID: 11860507.
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    83. Wensel TG. RGS9-1 phosphorylation and Ca2+. Adv Exp Med Biol. 2002; 514:125-9. PMID: 12596919.
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    84. He W, Wensel TG. RGS function in visual signal transduction. Methods Enzymol. 2002; 344:724-40. PMID: 11771423.
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    85. Shroyer NF, Lewis RA, Yatsenko AN, Wensel TG, Lupski JR. Cosegregation and functional analysis of mutant ABCR (ABCA4) alleles in families that manifest both Stargardt disease and age-related macular degeneration. Hum Mol Genet. 2001 Nov 01; 10(23):2671-8. PMID: 11726554.
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    86. He W, Melia TJ, Cowan CW, Wensel TG. Dependence of RGS9-1 membrane attachment on its C-terminal tail. J Biol Chem. 2001 Dec 28; 276(52):48961-6. PMID: 11677233.
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    87. Hu G, Jang GF, Cowan CW, Wensel TG, Palczewski K. Phosphorylation of RGS9-1 by an endogenous protein kinase in rod outer segments. J Biol Chem. 2001 Jun 22; 276(25):22287-95. PMID: 11292825.
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    88. Lyubarsky AL, Naarendorp F, Zhang X, Wensel T, Simon MI, Pugh EN. RGS9-1 is required for normal inactivation of mouse cone phototransduction. Mol Vis. 2001 Mar 20; 7:71-8. PMID: 11262419.
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    89. Sowa ME, He W, Slep KC, Kercher MA, Lichtarge O, Wensel TG. Prediction and confirmation of a site critical for effector regulation of RGS domain activity. Nat Struct Biol. 2001 Mar; 8(3):234-7. PMID: 11224568.
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    90. Slep KC, Kercher MA, He W, Cowan CW, Wensel TG, Sigler PB. Structural determinants for regulation of phosphodiesterase by a G protein at 2.0 A. Nature. 2001 Feb 22; 409(6823):1071-7. PMID: 11234020.
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    91. Cowan CW, He W, Wensel TG. RGS proteins: lessons from the RGS9 subfamily. Prog Nucleic Acid Res Mol Biol. 2001; 65:341-59. PMID: 11008492.
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    92. He W, Lu L, Zhang X, El-Hodiri HM, Chen CK, Slep KC, Simon MI, Jamrich M, Wensel TG. Modules in the photoreceptor RGS9-1.Gbeta 5L GTPase-accelerating protein complex control effector coupling, GTPase acceleration, protein folding, and stability. J Biol Chem. 2000 Nov 24; 275(47):37093-100. PMID: 10978345.
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    93. Intody Z, Perkins BD, Wilson JH, Wensel TG. Blocking transcription of the human rhodopsin gene by triplex-mediated DNA photocrosslinking. Nucleic Acids Res. 2000 Nov 01; 28(21):4283-90. PMID: 11058128.
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    94. He F, Seryshev AB, Cowan CW, Wensel TG. Multiple zinc binding sites in retinal rod cGMP phosphodiesterase, PDE6alpha beta. J Biol Chem. 2000 Jul 07; 275(27):20572-7. PMID: 10787404.
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    95. Womack KB, Gordon SE, He F, Wensel TG, Lu CC, Hilgemann DW. Do phosphatidylinositides modulate vertebrate phototransduction? J Neurosci. 2000 Apr 15; 20(8):2792-9. PMID: 10751430.
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    96. Sowa ME, He W, Wensel TG, Lichtarge O. A regulator of G protein signaling interaction surface linked to effector specificity. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1483-8. PMID: 10677488.
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    97. Kovoor A, Chen CK, He W, Wensel TG, Simon MI, Lester HA. Co-expression of Gbeta5 enhances the function of two Ggamma subunit-like domain-containing regulators of G protein signaling proteins. J Biol Chem. 2000 Feb 04; 275(5):3397-402. PMID: 10652332.
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    98. Melia TJ, Malinski JA, He F, Wensel TG. Enhancement of phototransduction protein interactions by lipid surfaces. J Biol Chem. 2000 Feb 04; 275(5):3535-42. PMID: 10652348.
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    99. Chen CK, Burns ME, He W, Wensel TG, Baylor DA, Simon MI. Slowed recovery of rod photoresponse in mice lacking the GTPase accelerating protein RGS9-1. Nature. 2000 Feb 03; 403(6769):557-60. PMID: 10676965.
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    100. Cowan CW, Wensel TG, Arshavsky VY. Enzymology of GTPase acceleration in phototransduction. Methods Enzymol. 2000; 315:524-38. PMID: 10736724.
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    101. Melia TJ, Sowa ME, Schutze L, Wensel TG. Formation of helical protein assemblies of IgG and transducin on varied lipid tubules. J Struct Biol. 1999 Dec 01; 128(1):119-30. PMID: 10600566.
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    102. Zhang K, Howes KA, He W, Bronson JD, Pettenati MJ, Chen C, Palczewski K, Wensel TG, Baehr W. Structure, alternative splicing, and expression of the human RGS9 gene. Gene. 1999 Nov 15; 240(1):23-34. PMID: 10564809.
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    103. Perkins BD, Wensel TG, Vasquez KM, Wilson JH. Psoralen photo-cross-linking by triplex-forming oligonucleotides at multiple sites in the human rhodopsin gene. Biochemistry. 1999 Sep 28; 38(39):12850-9. PMID: 10504255.
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    104. Rahman Z, Gold SJ, Potenza MN, Cowan CW, Ni YG, He W, Wensel TG, Nestler EJ. Cloning and characterization of RGS9-2: a striatal-enriched alternatively spliced product of the RGS9 gene. J Neurosci. 1999 Mar 15; 19(6):2016-26. PMID: 10066255.
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    105. DeMar JC, Rundle DR, Wensel TG, Anderson RE. Heterogeneous N-terminal acylation of retinal proteins. Prog Lipid Res. 1999 Jan; 38(1):49-90. PMID: 10396602.
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    106. Perkins BD, Wilson JH, Wensel TG, Vasquez KM. Triplex targets in the human rhodopsin gene. Biochemistry. 1998 Aug 11; 37(32):11315-22. PMID: 9698379.
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    107. Cowan CW, Fariss RN, Sokal I, Palczewski K, Wensel TG. High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods. Proc Natl Acad Sci U S A. 1998 Apr 28; 95(9):5351-6. PMID: 9560279.
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    108. He W, Cowan CW, Wensel TG. RGS9, a GTPase accelerator for phototransduction. Neuron. 1998 Jan; 20(1):95-102. PMID: 9459445.
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    109. Melia TJ, Cowan CW, Angleson JK, Wensel TG. A comparison of the efficiency of G protein activation by ligand-free and light-activated forms of rhodopsin. Biophys J. 1997 Dec; 73(6):3182-91. PMID: 9414230.
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    110. Vasquez KM, Wensel TG, Hogan ME, Wilson JH. High-efficiency triple-helix-mediated photo-cross-linking at a targeted site within a selectable mammalian gene. Biochemistry. 1996 Aug 20; 35(33):10712-9. PMID: 8718860.
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    111. Zera EM, Molloy DP, Angleson JK, Lamture JB, Wensel TG, Malinski JA. Low affinity interactions of GDPbetaS and ribose- or phosphoryl-substituted GTP analogues with the heterotrimeric G protein, transducin. J Biol Chem. 1996 May 31; 271(22):12925-31. PMID: 8662741.
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    112. Malinski JA, Zera EM, Angleson JK, Wensel TG. High affinity interactions of GTPgammaS with the heterotrimeric G protein, transducin. Evidence at high and low protein concentrations. J Biol Chem. 1996 May 31; 271(22):12919-24. PMID: 8662740.
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    113. DeMar JC, Wensel TG, Anderson RE. Biosynthesis of the unsaturated 14-carbon fatty acids found on the N termini of photoreceptor-specific proteins. J Biol Chem. 1996 Mar 01; 271(9):5007-16. PMID: 8617777.
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    114. Vasquez KM, Wensel TG, Hogan ME, Wilson JH. High-affinity triple helix formation by synthetic oligonucleotides at a site within a selectable mammalian gene. Biochemistry. 1995 May 30; 34(21):7243-51. PMID: 7766635.
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    115. Lamture JB, Wensel TG. Intensely luminescent immunoreactive conjugates of proteins and dipicolinate-based polymeric Tb (III) chelates. Bioconjug Chem. 1995 Jan-Feb; 6(1):88-92. PMID: 7711110.
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    116. Angleson JK, Wensel TG. Enhancement of rod outer segment GTPase accelerating protein activity by the inhibitory subunit of cGMP phosphodiesterase. J Biol Chem. 1994 Jun 10; 269(23):16290-6. PMID: 8206935.
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    117. Angleson JK, Wensel TG. A GTPase-accelerating factor for transducin, distinct from its effector cGMP phosphodiesterase, in rod outer segment membranes. Neuron. 1993 Nov; 11(5):939-49. PMID: 8240815.
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    118. Yang Z, Wensel TG. Inorganic pyrophosphatase from bovine retinal rod outer segments. J Biol Chem. 1992 Dec 05; 267(34):24634-40. PMID: 1360011.
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    119. Yang Z, Wensel TG. Molecular cloning and functional expression of cDNA encoding a mammalian inorganic pyrophosphatase. J Biol Chem. 1992 Dec 05; 267(34):24641-7. PMID: 1339444.
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    120. Yang Z, Wensel TG. N-myristoylation of the rod outer segment G protein, transducin, in cultured retinas. J Biol Chem. 1992 Nov 15; 267(32):23197-201. PMID: 1429667.
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    121. Malinski JA, Wensel TG. Membrane stimulation of cGMP phosphodiesterase activation by transducin: comparison of phospholipid bilayers to rod outer segment membranes. Biochemistry. 1992 Oct 06; 31(39):9502-12. PMID: 1327116.
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    122. Ramdas L, Disher RM, Wensel TG. Nucleotide exchange and cGMP phosphodiesterase activation by pertussis toxin inactivated transducin. Biochemistry. 1991 Dec 17; 30(50):11637-45. PMID: 1661143.
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    123. Keating SM, Wensel TG. Nanosecond fluorescence microscopy. Emission kinetics of fura-2 in single cells. Biophys J. 1991 Jan; 59(1):186-202. PMID: 2015383.
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    124. Northrup SH, Wensel TG, Meares CF, Wendoloski JJ, Matthew JB. Electrostatic field around cytochrome c: theory and energy transfer experiment. Proc Natl Acad Sci U S A. 1990 Dec; 87(23):9503-7. PMID: 2174564.
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    125. Holowka D, Wensel T, Baird B. A nanosecond fluorescence depolarization study on the segmental flexibility of receptor-bound immunoglobulin E. Biochemistry. 1990 May 15; 29(19):4607-12. PMID: 2142605.
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    126. Wensel TG, Stryer L. Activation mechanism of retinal rod cyclic GMP phosphodiesterase probed by fluorescein-labeled inhibitory subunit. Biochemistry. 1990 Feb 27; 29(8):2155-61. PMID: 2158346.
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    127. Meyer T, Wensel T, Stryer L. Kinetics of calcium channel opening by inositol 1,4,5-trisphosphate. Biochemistry. 1990 Jan 09; 29(1):32-7. PMID: 1691015.
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    128. Dangl JL, Wensel TG, Morrison SL, Stryer L, Herzenberg LA, Oi VT. Segmental flexibility and complement fixation of genetically engineered chimeric human, rabbit and mouse antibodies. EMBO J. 1988 Jul; 7(7):1989-94. PMID: 3138110.
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    129. Schneider WP, Wensel TG, Stryer L, Oi VT. Genetically engineered immunoglobulins reveal structural features controlling segmental flexibility. Proc Natl Acad Sci U S A. 1988 Apr; 85(8):2509-13. PMID: 3128789.
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    130. Wensel TG, Stryer L. Reciprocal control of retinal rod cyclic GMP phosphodiesterase by its gamma subunit and transducin. Proteins. 1986 Sep; 1(1):90-9. PMID: 2835761.
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    131. Wensel TG, Meares CF, Vlachy V, Matthew JB. Distribution of ions around DNA, probed by energy transfer. Proc Natl Acad Sci U S A. 1986 May; 83(10):3267-71. PMID: 3458180.
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    132. Haseman MK, Goodwin DA, Meares CF, Kaminski MS, Wensel TG, McCall MJ, Levy R. Metabolizable 111In chelate conjugated anti-idiotype monoclonal antibody for radioimmunodetection of lymphoma in mice. Eur J Nucl Med. 1986; 12(9):455-60. PMID: 3102237.
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    133. Wensel TG, Chang CH, Meares CF. Diffusion-enhanced lanthanide energy-transfer study of DNA-bound cobalt(III) bleomycins: comparisons of accessibility and electrostatic potential with DNA complexes of ethidium and acridine orange. Biochemistry. 1985 Jun 04; 24(12):3060-9. PMID: 2410019.
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