STEPHEN PFLUGFELDER

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Ophthalmology
Address6501 Fannin St
Houston, TX 77030
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    R03EY008193     (PFLUGFELDER, STEPHEN CARL)Mar 1, 1989 - Feb 28, 1990
    NIH/NEI
    DETECTION OF EPSTEIN-BARR VIRAL DNA IN OCULAR SPECIMENS
    Role: Principal Investigator

    R01EY008711     (PFLUGFELDER, STEPHEN CARL)Aug 1, 1990 - Jul 31, 1994
    NIH/NEI
    EBV AND OCULAR PATHOLOGY IN SJOGREN'S SYNDROME
    Role: Principal Investigator

    R01EY011915     (PFLUGFELDER, STEPHEN C)Aug 1, 1997 - Sep 30, 2006
    NIH/NEI
    Pathogenesis of Conjunctival Squamous Metaplasia
    Role: Principal Investigator

    R01EY018090     (PFLUGFELDER, STEPHEN CARL)Aug 1, 2009 - Jul 31, 2011
    NIH/NEI
    Environmentally-Induced Ocular Surface Inflammation Mimicking Sjogren's Syndrome
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Perez VL, Stern ME, Pflugfelder SC. Inflammatory basis for dry eye disease flares. Exp Eye Res. 2020 Oct 08; 108294. PMID: 33039458.
      Citations:    Fields:    
    2. Pflugfelder SC, Stern ME. The cornea in keratoconjunctivitis sicca. Exp Eye Res. 2020 Oct 07; 201:108295. PMID: 33038387.
      Citations:    Fields:    
    3. Ganugula R, Arora M, Lepiz MA, Niu Y, Mallick BK, Pflugfelder SC, Scott EM, Kumar MNVR. Systemic anti-inflammatory therapy aided by double-headed nanoparticles in a canine model of acute intraocular inflammation. Sci Adv. 2020 Aug; 6(35):eabb7878. PMID: 32923645.
      Citations:    Fields:    
    4. Liu Z, Chen D, Chen X, Bian F, Qin W, Gao N, Xiao Y, Li J, Pflugfelder SC, Li DQ. Trehalose Induces Autophagy Against Inflammation by Activating TFEB Signaling Pathway in Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress. Invest Ophthalmol Vis Sci. 2020 Aug 03; 61(10):26. PMID: 32785678.
      Citations:    Fields:    
    5. Kamal SM, Riccobono K, Kwok A, Edmond JC, Pflugfelder SC. Unilateral pediatric neurotrophic keratitis due to congenital left trigeminal nerve aplasia with PROSE (prosthetic replacement of the ocular surface ecosystem) treatment. Am J Ophthalmol Case Rep. 2020 Dec; 20:100854. PMID: 33094195.
      Citations:    
    6. Alam J, de Souza RG, Yu Z, Stern ME, de Paiva CS, Pflugfelder SC. Calcineurin Inhibitor Voclosporin Preserves Corneal Barrier and Conjunctival Goblet Cells in Experimental Dry Eye. J Ocul Pharmacol Ther. 2020 11; 36(9):679-685. PMID: 32721249.
      Citations:    Fields:    
    7. Pflugfelder SC, de Paiva CS. Goblet cells promote tolerance induction in the conjunctiva. Mucosal Immunol. 2020 09; 13(5):717-718. PMID: 32616838.
      Citations:    Fields:    Translation:Cells
    8. Pflugfelder SC, Stern ME. Biological functions of tear film. Exp Eye Res. 2020 Aug; 197:108115. PMID: 32561483.
      Citations:    Fields:    
    9. Utine CA, Li G, Asbell P, Pflugfelder S, Akpek E. Ocular surface disease associated with dupilumab treatment for atopic diseases. Ocul Surf. 2020 May 18. PMID: 32439390.
      Citations: 1     Fields:    
    10. Hu J, Gao N, Zhang Y, Chen X, Li J, Bian F, Chi W, Liu Z, de Paiva CS, Pflugfelder SC, Li DQ. IL-33/ST2/IL-9/IL-9R signaling disrupts ocular surface barrier in allergic inflammation. Mucosal Immunol. 2020 11; 13(6):919-930. PMID: 32358573.
      Citations:    Fields:    
    11. Khimani KS, Go JA, De Souza RG, Mitchell T, Yu Z, de Paiva CS, Saumur M, Pflugfelder SC. Regional Comparison of Goblet Cell Number and Area in Exposed and Covered Dry Eyes and Their Correlation with Tear MUC5AC. Sci Rep. 2020 02 19; 10(1):2933. PMID: 32076085.
      Citations:    Fields:    
    12. de Paiva CS, Pflugfelder SC. Mechanisms of Disease in Sjögren Syndrome-New Developments and Directions. Int J Mol Sci. 2020 Jan 19; 21(2). PMID: 31963817.
      Citations:    Fields:    Translation:HumansCells
    13. Alam J, de Paiva CS, Pflugfelder SC. Immune - Goblet cell interaction in the conjunctiva. Ocul Surf. 2020 04; 18(2):326-334. PMID: 31953222.
      Citations:    Fields:    
    14. Trujillo-Vargas CM, Schaefer L, Alam J, Pflugfelder SC, Britton RA, de Paiva CS. The gut-eye-lacrimal gland-microbiome axis in Sjögren Syndrome. Ocul Surf. 2020 04; 18(2):335-344. PMID: 31644955.
      Citations:    Fields:    
    15. Wang C, Schaefer L, Bian F, Yu Z, Pflugfelder SC, Britton RA, de Paiva CS. Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide. Invest Ophthalmol Vis Sci. 2019 10 01; 60(13):4224-4233. PMID: 31618426.
      Citations:    Fields:    Translation:Animals
    16. de Paiva CS, Pflugfelder SC, Ng SM, Akpek EK. Topical cyclosporine A therapy for dry eye syndrome. Cochrane Database Syst Rev. 2019 09 13; 9:CD010051. PMID: 31517988.
      Citations: 4     Fields:    Translation:Humans
    17. Hsu JI, Pflugfelder SC, Kim SJ. Ocular complications of atopic dermatitis. Cutis. 2019 Sep; 104(3):189-193. PMID: 31675394.
      Citations:    Fields:    Translation:Humans
    18. Pflugfelder SC, Massaro-Giordano M, Perez VL, Hamrah P, Deng SX, Espandar L, Foster CS, Affeldt J, Seedor JA, Afshari NA, Chao W, Allegretti M, Mantelli F, Dana R. Topical Recombinant Human Nerve Growth Factor (Cenegermin) for Neurotrophic Keratopathy: A Multicenter Randomized Vehicle-Controlled Pivotal Trial. Ophthalmology. 2020 01; 127(1):14-26. PMID: 31585826.
      Citations: 2     Fields:    Translation:Humans
    19. Deng R, Chen X, Zhang Y, Bian F, Gao N, Hu J, Wang C, de Souza RG, Lu F, Pflugfelder SC, Li DQ. Short ragweed pollen promotes M2 macrophage polarization via TSLP/TSLPR/OX40L signaling in allergic inflammation. Mucosal Immunol. 2019 09; 12(5):1141-1149. PMID: 31350466.
      Citations: 1     Fields:    Translation:AnimalsCells
    20. Bian F, Xiao Y, Barbosa FL, de Souza RG, Hernandez H, Yu Z, Pflugfelder SC, de Paiva CS. Age-associated antigen-presenting cell alterations promote dry-eye inducing Th1 cells. Mucosal Immunol. 2019 07; 12(4):897-908. PMID: 30696983.
      Citations: 6     Fields:    Translation:AnimalsCells
    21. Chen X, Deng R, Chi W, Hua X, Lu F, Bian F, Gao N, Li Z, Pflugfelder SC, de Paiva CS, Li DQ. IL-27 signaling deficiency develops Th17-enhanced Th2-dominant inflammation in murine allergic conjunctivitis model. Allergy. 2019 05; 74(5):910-921. PMID: 30515838.
      Citations: 3     Fields:    Translation:AnimalsCells
    22. Stepp MA, Pal-Ghosh S, Tadvalkar G, Williams AR, Pflugfelder SC, de Paiva CS. Reduced Corneal Innervation in the CD25 Null Model of Sjögren Syndrome. Int J Mol Sci. 2018 Nov 30; 19(12). PMID: 30513621.
      Citations: 3     Fields:    Translation:Animals
    23. Stamer WD, Williams AM, Pflugfelder S, Coupland SE. Accessibility to and Quality of Human Eye Tissue for Research: A Cross-Sectional Survey of ARVO Members. Invest Ophthalmol Vis Sci. 2018 10 01; 59(12):4783-4792. PMID: 30304462.
      Citations: 3     Fields:    Translation:Humans
    24. Xiao Y, de Paiva CS, Yu Z, de Souza RG, Li DQ, Pflugfelder SC. Goblet cell-produced retinoic acid suppresses CD86 expression and IL-12 production in bone marrow-derived cells. Int Immunol. 2018 09 25; 30(10):457-470. PMID: 30010888.
      Citations: 3     Fields:    Translation:AnimalsCells
    25. Pflugfelder SC, Bian F, Gumus K, Farley W, Stern ME, De Paiva CS. Severity of Sjögren's Syndrome Keratoconjunctivitis Sicca Increases with Increased Percentage of Conjunctival Antigen-Presenting Cells. Int J Mol Sci. 2018 Sep 14; 19(9). PMID: 30223431.
      Citations: 8     Fields:    Translation:HumansCells
    26. Guimaraes de Souza R, Yu Z, Stern ME, Pflugfelder SC, de Paiva CS. Suppression of Th1-Mediated Keratoconjunctivitis Sicca by Lifitegrast. J Ocul Pharmacol Ther. 2018 09; 34(7):543-549. PMID: 29958030.
      Citations: 4     Fields:    Translation:AnimalsCells
    27. Zaheer M, Wang C, Bian F, Yu Z, Hernandez H, de Souza RG, Simmons KT, Schady D, Swennes AG, Pflugfelder SC, Britton RA, de Paiva CS. Protective role of commensal bacteria in Sjögren Syndrome. J Autoimmun. 2018 09; 93:45-56. PMID: 29934134.
      Citations: 3     Fields:    Translation:AnimalsCells
    28. Patel SN, Shetlar DJ, Pflugfelder SC. Bilateral Candida parapsilosis infiltration of nonhealing indolent epithelial defects in a diabetic patient with neurotrophic keratopathy. Can J Ophthalmol. 2018 12; 53(6):e224-e226. PMID: 30502998.
      Citations:    Fields:    Translation:HumansAnimals
    29. Yang J, Chandwani R, Gopinatth V, Boyce T, Pflugfelder SC, Huang D, Liu G. Near-infrared laser thermal conjunctivoplasty. Sci Rep. 2018 03 01; 8(1):3863. PMID: 29497112.
      Citations: 1     Fields:    Translation:Animals
    30. Wang C, Zaheer M, Bian F, Quach D, Swennes AG, Britton RA, Pflugfelder SC, de Paiva CS. Sjögren-Like Lacrimal Keratoconjunctivitis in Germ-Free Mice. Int J Mol Sci. 2018 Feb 13; 19(2). PMID: 29438346.
      Citations: 8     Fields:    Translation:AnimalsCells
    31. Ko BY, Xiao Y, Barbosa FL, de Paiva CS, Pflugfelder SC. Goblet cell loss abrogates ocular surface immune tolerance. JCI Insight. 2018 02 08; 3(3). PMID: 29415888.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    32. Parra AS, Roth BM, Nguyen TM, Wang L, Pflugfelder SC, Al-Mohtaseb Z. Assessment of the Prosthetic Replacement of Ocular Surface Ecosystem (PROSE) scleral lens on visual acuity for corneal irregularity and ocular surface disease. Ocul Surf. 2018 04; 16(2):254-258. PMID: 29425812.
      Citations: 2     Fields:    Translation:Humans
    33. Stepp MA, Pal-Ghosh S, Tadvalkar G, Williams A, Pflugfelder SC, de Paiva CS. Reduced intraepithelial corneal nerve density and sensitivity accompany desiccating stress and aging in C57BL/6 mice. Exp Eye Res. 2018 04; 169:91-98. PMID: 29407221.
      Citations: 10     Fields:    Translation:AnimalsCells
    34. McDonnell PJ, Pflugfelder SC, Stern ME, Hardten DR, Conway T, Villanueva L, Hollander DA. Study design and baseline findings from the progression of ocular findings (PROOF) natural history study of dry eye. BMC Ophthalmol. 2017 Dec 28; 17(1):265. PMID: 29284427.
      Citations: 3     Fields:    Translation:Humans
    35. Pflugfelder SC, de Paiva CS. The Pathophysiology of Dry Eye Disease: What We Know and Future Directions for Research. Ophthalmology. 2017 11; 124(11S):S4-S13. PMID: 29055361.
      Citations: 32     Fields:    Translation:HumansCells
    36. Li J, Xiao Y, Coursey TG, Chen X, Deng R, Lu F, Pflugfelder SC, Li DQ. Identification for Differential Localization of Putative Corneal Epithelial Stem Cells in Mouse and Human. Sci Rep. 2017 07 12; 7(1):5169. PMID: 28701781.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    37. Barbosa FL, Xiao Y, Bian F, Coursey TG, Ko BY, Clevers H, de Paiva CS, Pflugfelder SC. Goblet Cells Contribute to Ocular Surface Immune Tolerance-Implications for Dry Eye Disease. Int J Mol Sci. 2017 May 05; 18(5). PMID: 28475124.
      Citations: 16     Fields:    Translation:AnimalsCells
    38. Jin H, Parker WT, Law NW, Clarke CL, Gisseman JD, Pflugfelder SC, Wang L, Al-Mohtaseb ZN. Evolving risk factors and antibiotic sensitivity patterns for microbial keratitis at a large county hospital. Br J Ophthalmol. 2017 11; 101(11):1483-1487. PMID: 28336675.
      Citations: 6     Fields:    Translation:Humans
    39. Zhao YE, Gong XH, Zhu XN, Li HM, Tu MJ, Coursey TG, Pflugfelder SC, Gu F, Chen D. Long-term outcomes of ciliary sulcus versus capsular bag fixation of intraocular lenses in children: An ultrasound biomicroscopy study. PLoS One. 2017; 12(3):e0172979. PMID: 28301497.
      Citations: 4     Fields:    Translation:Humans
    40. Gumus K, Schuetzle KL, Pflugfelder SC. Randomized Controlled Crossover Trial Comparing the Impact of Sham or Intranasal Tear Neurostimulation on Conjunctival Goblet Cell Degranulation. Am J Ophthalmol. 2017 May; 177:159-168. PMID: 28302532.
      Citations: 4     Fields:    Translation:HumansCells
    41. Bian F, Xiao Y, Zaheer M, Volpe EA, Pflugfelder SC, Li DQ, de Paiva CS. Inhibition of NLRP3 Inflammasome Pathway by Butyrate Improves Corneal Wound Healing in Corneal Alkali Burn. Int J Mol Sci. 2017 Mar 05; 18(3). PMID: 28273882.
      Citations: 8     Fields:    Translation:Animals
    42. Chi W, Hua X, Chen X, Bian F, Yuan X, Zhang L, Wang X, Chen D, Deng R, Li Z, Liu Y, de Paiva CS, Pflugfelder SC, Li DQ. Mitochondrial DNA oxidation induces imbalanced activity of NLRP3/NLRP6 inflammasomes by activation of caspase-8 and BRCC36 in dry eye. J Autoimmun. 2017 Jun; 80:65-76. PMID: 28238526.
      Citations: 6     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    43. Chen D, Qu Y, Hua X, Zhang L, Liu Z, Pflugfelder SC, Li DQ. A hyaluronan hydrogel scaffold-based xeno-free culture system for ex vivo expansion of human corneal epithelial stem cells. Eye (Lond). 2017 Jun; 31(6):962-971. PMID: 28211875.
      Citations: 6     Fields:    Translation:HumansCells
    44. Gumus K, Pflugfelder SC. Intranasal Tear Neurostimulation: An Emerging Concept in the Treatment of Dry Eye. Int Ophthalmol Clin. 2017; 57(2):101-108. PMID: 28282317.
      Citations: 3     Fields:    Translation:Humans
    45. Pflugfelder SC, Gumus K, Feuerman J, Alex A. Tear Volume-based Diagnostic Classification for Tear Dysfunction. Int Ophthalmol Clin. 2017; 57(2):1-12. PMID: 28282310.
      Citations: 1     Fields:    Translation:Humans
    46. Gumus K, Pflugfelder SC. Anterior Segment Optical Coherence Tomography (AS-OCT) in the Management of Dry Eye. Int Ophthalmol Clin. 2017; 57(2):13-22. PMID: 28282311.
      Citations: 1     Fields:    Translation:Humans
    47. Stern ME, Pflugfelder SC. What We Have Learned From Animal Models of Dry Eye. Int Ophthalmol Clin. 2017; 57(2):109-118. PMID: 28282318.
      Citations: 3     Fields:    Translation:HumansAnimals
    48. Pflugfelder SC, Stern M, Zhang S, Shojaei A. LFA-1/ICAM-1 Interaction as a Therapeutic Target in Dry Eye Disease. J Ocul Pharmacol Ther. 2017 Jan/Feb; 33(1):5-12. PMID: 27906544.
      Citations: 19     Fields:    Translation:HumansAnimals
    49. Li J, Zhang L, Chen X, Chen D, Hua X, Bian F, Deng R, Lu F, Li Z, Pflugfelder SC, Li DQ. Pollen/TLR4 Innate Immunity Signaling Initiates IL-33/ST2/Th2 Pathways in Allergic Inflammation. Sci Rep. 2016 10 31; 6:36150. PMID: 27796360.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    50. Coursey TG, Bian F, Zaheer M, Pflugfelder SC, Volpe EA, de Paiva CS. Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells. Mucosal Immunol. 2017 05; 10(3):743-756. PMID: 27706128.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    51. Volpe EA, Henriksson JT, Wang C, Barbosa FL, Zaheer M, Zhang X, Pflugfelder SC, de Paiva CS. Interferon-gamma deficiency protects against aging-related goblet cell loss. Oncotarget. 2016 10 04; 7(40):64605-64614. PMID: 27623073.
      Citations: 7     Fields:    Translation:AnimalsCells
    52. Marcano DC, Shin CS, Lee B, Isenhart LC, Liu X, Li F, Jester JV, Pflugfelder SC, Simpson J, Acharya G. Synergistic Cysteamine Delivery Nanowafer as an Efficacious Treatment Modality for Corneal Cystinosis. Mol Pharm. 2016 10 03; 13(10):3468-3477. PMID: 27571217.
      Citations: 5     Fields:    Translation:Animals
    53. Bian F, Shin CS, Wang C, Pflugfelder SC, Acharya G, De Paiva CS. Dexamethasone Drug Eluting Nanowafers Control Inflammation in Alkali-Burned Corneas Associated With Dry Eye. Invest Ophthalmol Vis Sci. 2016 06 01; 57(7):3222-30. PMID: 27327581.
      Citations: 4     Fields:    Translation:Animals
    54. Simmons KT, Xiao Y, Pflugfelder SC, de Paiva CS. Inflammatory Response to Lipopolysaccharide on the Ocular Surface in a Murine Dry Eye Model. Invest Ophthalmol Vis Sci. 2016 05 01; 57(6):2443-51. PMID: 27136463.
      Citations: 6     Fields:    Translation:AnimalsCells
    55. de Paiva CS, Jones DB, Stern ME, Bian F, Moore QL, Corbiere S, Streckfus CF, Hutchinson DS, Ajami NJ, Petrosino JF, Pflugfelder SC. Altered Mucosal Microbiome Diversity and Disease Severity in Sjögren Syndrome. Sci Rep. 2016 Apr 18; 6:23561. PMID: 27087247.
      Citations: 50     Fields:    Translation:HumansAnimals
    56. Coursey TG, Tukler Henriksson J, Barbosa FL, de Paiva CS, Pflugfelder SC. Interferon-?-Induced Unfolded Protein Response in Conjunctival Goblet Cells as a Cause of Mucin Deficiency in Sjögren Syndrome. Am J Pathol. 2016 06; 186(6):1547-58. PMID: 27085137.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    57. Bian F, Wang C, Tukler-Henriksson J, Pflugfelder SC, Camodeca C, Nuti E, Rossello A, Li DQ, de Paiva CS. MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions. J Cell Physiol. 2016 11; 231(11):2506-16. PMID: 26923552.
      Citations: 3     Fields:    Translation:AnimalsCells
    58. Kohanim S, Palioura S, Saeed HN, Akpek EK, Amescua G, Basu S, Blomquist PH, Bouchard CS, Dart JK, Gai X, Gomes JA, Gregory DG, Iyer G, Jacobs DS, Johnson AJ, Kinoshita S, Mantagos IS, Mehta JS, Perez VL, Pflugfelder SC, Sangwan VS, Sippel KC, Sotozono C, Srinivasan B, Tan DT, Tandon R, Tseng SC, Ueta M, Chodosh J. Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. II. Ophthalmic Disease. Ocul Surf. 2016 04; 14(2):168-88. PMID: 26882981.
      Citations: 18     Fields:    Translation:Humans
    59. Perez VL, Pflugfelder SC, Zhang S, Shojaei A, Haque R. Lifitegrast, a Novel Integrin Antagonist for Treatment of Dry Eye Disease. Ocul Surf. 2016 04; 14(2):207-15. PMID: 26807723.
      Citations: 29     Fields:    Translation:Humans
    60. Li J, Hua X, Zhang L, Lu F, Coursey TG, Pflugfelder SC, Li DQ. Blueberry Component Pterostilbene Protects Corneal Epithelial Cells from Inflammation via Anti-oxidative Pathway. Sci Rep. 2016 Jan 14; 6:19408. PMID: 26762881.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    61. Bian F, Pelegrino FS, Henriksson JT, Pflugfelder SC, Volpe EA, Li DQ, de Paiva CS. Differential Effects of Dexamethasone and Doxycycline on Inflammation and MMP Production in Murine Alkali-Burned Corneas Associated with Dry Eye. Ocul Surf. 2016 04; 14(2):242-54. PMID: 26772899.
      Citations: 18     Fields:    Translation:Animals
    62. Kohanim S, Palioura S, Saeed HN, Akpek EK, Amescua G, Basu S, Blomquist PH, Bouchard CS, Dart JK, Gai X, Gomes JA, Gregory DG, Iyer G, Jacobs DS, Johnson AJ, Kinoshita S, Mantagos IS, Mehta JS, Perez VL, Pflugfelder SC, Sangwan VS, Sippel KC, Sotozono C, Srinivasan B, Tan DT, Tandon R, Tseng SC, Ueta M, Chodosh J. Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis--A Comprehensive Review and Guide to Therapy. I. Systemic Disease. Ocul Surf. 2016 Jan; 14(1):2-19. PMID: 26549248.
      Citations: 16     Fields:    Translation:Humans
    63. Pflugfelder SC, De Paiva CS, Moore QL, Volpe EA, Li DQ, Gumus K, Zaheer ML, Corrales RM. Aqueous Tear Deficiency Increases Conjunctival Interferon-? (IFN-?) Expression and Goblet Cell Loss. Invest Ophthalmol Vis Sci. 2015 Nov; 56(12):7545-50. PMID: 26618646.
      Citations: 30     Fields:    Translation:HumansCells
    64. Zhang L, Su Z, Zhang Z, Lin J, Li DQ, Pflugfelder SC. Effects of azithromycin on gene expression profiles of proinflammatory and anti-inflammatory mediators in the eyelid margin and conjunctiva of patients with meibomian gland disease. JAMA Ophthalmol. 2015 Oct; 133(10):1117-23. PMID: 26204109.
      Citations: 11     Fields:    Translation:HumansCells
    65. Bauskar A, Mack WJ, Mauris J, Argüeso P, Heur M, Nagel BA, Kolar GR, Gleave ME, Nakamura T, Kinoshita S, Moradian-Oldak J, Panjwani N, Pflugfelder SC, Wilson MR, Fini ME, Jeong S. Clusterin Seals the Ocular Surface Barrier in Mouse Dry Eye. PLoS One. 2015; 10(9):e0138958. PMID: 26402857.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    66. Krauss AH, Corrales RM, Pelegrino FS, Tukler-Henriksson J, Pflugfelder SC, de Paiva CS. Improvement of Outcome Measures of Dry Eye by a Novel Integrin Antagonist in the Murine Desiccating Stress Model. Invest Ophthalmol Vis Sci. 2015 Sep; 56(10):5888-95. PMID: 26348638.
      Citations: 6     Fields:    Translation:AnimalsCells
    67. Rahman EZ, Lam PK, Chu CK, Moore Q, Pflugfelder SC. Corneal Sensitivity in Tear Dysfunction and its Correlation With Clinical Parameters and Blink Rate. Am J Ophthalmol. 2015 Nov; 160(5):858-866.e5. PMID: 26255576.
      Citations: 13     Fields:    Translation:Humans
    68. Hua X, Deng R, Li J, Chi W, Su Z, Lin J, Pflugfelder SC, Li DQ. Protective Effects of L-Carnitine Against Oxidative Injury by Hyperosmolarity in Human Corneal Epithelial Cells. Invest Ophthalmol Vis Sci. 2015 Aug; 56(9):5503-11. PMID: 26284556.
      Citations: 13     Fields:    Translation:HumansCells
    69. Coursey TG, Henriksson JT, Marcano DC, Shin CS, Isenhart LC, Ahmed F, De Paiva CS, Pflugfelder SC, Acharya G. Dexamethasone nanowafer as an effective therapy for dry eye disease. J Control Release. 2015 Sep 10; 213:168-174. PMID: 26184051.
      Citations: 16     Fields:    Translation:Animals
    70. Tukler Henriksson J, Coursey TG, Corry DB, De Paiva CS, Pflugfelder SC. IL-13 Stimulates Proliferation and Expression of Mucin and Immunomodulatory Genes in Cultured Conjunctival Goblet Cells. Invest Ophthalmol Vis Sci. 2015 Jul; 56(8):4186-97. PMID: 26132778.
      Citations: 24     Fields:    Translation:AnimalsCells
    71. Bian F, Pelegrino FS, Pflugfelder SC, Volpe EA, Li DQ, de Paiva CS. Desiccating Stress-Induced MMP Production and Activity Worsens Wound Healing in Alkali-Burned Corneas. Invest Ophthalmol Vis Sci. 2015 Jul; 56(8):4908-18. PMID: 26225631.
      Citations: 8     Fields:    Translation:Animals
    72. Hua X, Yuan X, Li Z, Coursey TG, Pflugfelder SC, Li DQ. A Novel Innate Response of Human Corneal Epithelium to Heat-killed Candida albicans by Producing Peptidoglycan Recognition Proteins. PLoS One. 2015; 10(6):e0128039. PMID: 26039076.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    73. Deng R, Hua X, Li J, Chi W, Zhang Z, Lu F, Zhang L, Pflugfelder SC, Li DQ. Oxidative stress markers induced by hyperosmolarity in primary human corneal epithelial cells. PLoS One. 2015; 10(5):e0126561. PMID: 26024535.
      Citations: 31     Fields:    Translation:HumansCells
    74. Moore QL, De Paiva CS, Pflugfelder SC. Effects of Dry Eye Therapies on Environmentally Induced Ocular Surface Disease. Am J Ophthalmol. 2015 Jul; 160(1):135-42.e1. PMID: 25868759.
      Citations: 11     Fields:    Translation:HumansCTClinical Trials
    75. You IC, Bian F, Volpe EA, de Paiva CS, Pflugfelder SC. Age-Related Conjunctival Disease in the C57BL/6.NOD-Aec1Aec2 Mouse Model of Sjögren Syndrome Develops Independent of Lacrimal Dysfunction. Invest Ophthalmol Vis Sci. 2015 Apr; 56(4):2224-33. PMID: 25758816.
      Citations: 10     Fields:    Translation:Animals
    76. You IC, Coursey TG, Bian F, Barbosa FL, de Paiva CS, Pflugfelder SC. Macrophage Phenotype in the Ocular Surface of Experimental Murine Dry Eye Disease. Arch Immunol Ther Exp (Warsz). 2015 Aug; 63(4):299-304. PMID: 25772203.
      Citations: 8     Fields:    Translation:AnimalsCells
    77. Bian F, Barbosa FL, Corrales RM, Pelegrino FS, Volpe EA, Pflugfelder SC, de Paiva CS. Altered balance of interleukin-13/interferon-gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sjögren's syndrome. Arthritis Res Ther. 2015 Mar 10; 17:53. PMID: 25889094.
      Citations: 10     Fields:    Translation:Animals
    78. Qu Y, Chi W, Hua X, Deng R, Li J, Liu Z, Pflugfelder SC, Li DQ. Unique expression pattern and functional role of periostin in human limbal stem cells. PLoS One. 2015; 10(2):e0117139. PMID: 25658308.
      Citations: 5     Fields:    Translation:HumansCells
    79. Yuan X, Marcano DC, Shin CS, Hua X, Isenhart LC, Pflugfelder SC, Acharya G. Ocular drug delivery nanowafer with enhanced therapeutic efficacy. ACS Nano. 2015 Feb 24; 9(2):1749-58. PMID: 25585134.
      Citations: 14     Fields:    Translation:AnimalsCells
    80. Foulks GN, Forstot SL, Donshik PC, Forstot JZ, Goldstein MH, Lemp MA, Nelson JD, Nichols KK, Pflugfelder SC, Tanzer JM, Asbell P, Hammitt K, Jacobs DS. Clinical guidelines for management of dry eye associated with Sjögren disease. Ocul Surf. 2015 Apr; 13(2):118-32. PMID: 25881996.
      Citations: 41     Fields:    Translation:Humans
    81. Coursey TG, Bohat R, Barbosa FL, Pflugfelder SC, de Paiva CS. Desiccating stress-induced chemokine expression in the epithelium is dependent on upregulation of NKG2D/RAE-1 and release of IFN-? in experimental dry eye. J Immunol. 2014 Nov 15; 193(10):5264-72. PMID: 25288568.
      Citations: 17     Fields:    Translation:AnimalsCells
    82. Hua X, Su Z, Deng R, Lin J, Li DQ, Pflugfelder SC. Effects of L-carnitine, erythritol and betaine on pro-inflammatory markers in primary human corneal epithelial cells exposed to hyperosmotic stress. Curr Eye Res. 2015 Jul; 40(7):657-67. PMID: 25271595.
      Citations: 16     Fields:    Translation:HumansCells
    83. Deng R, Su Z, Hua X, Zhang Z, Li DQ, Pflugfelder SC. Osmoprotectants suppress the production and activity of matrix metalloproteinases induced by hyperosmolarity in primary human corneal epithelial cells. Mol Vis. 2014; 20:1243-52. PMID: 25352733.
      Citations: 9     Fields:    Translation:HumansCells
    84. Sheppard JD, Donnenfeld ED, Holland EJ, Slonim CB, Solomon R, Solomon KD, McDonald MB, Perry HD, Lane SS, Pflugfelder SC, Samudre SS. Effect of loteprednol etabonate 0.5% on initiation of dry eye treatment with topical cyclosporine 0.05%. Eye Contact Lens. 2014 Sep; 40(5):289-96. PMID: 25083776.
      Citations: 13     Fields:    Translation:Humans
    85. Pflugfelder SC, Stern ME. Mucosal environmental sensors in the pathogenesis of dry eye. Expert Rev Clin Immunol. 2014 Sep; 10(9):1137-40. PMID: 25075545.
      Citations: 12     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    86. Vo RC, Stafeeva K, Aldave AJ, Stulting RD, Moore Q, Pflugfelder SC, Chungfat NC, Holsclaw DS, Margolis TP, Deng SX. Complications related to a cosmetic eye-whitening procedure. Am J Ophthalmol. 2014 Nov; 158(5):967-73. PMID: 25072832.
      Citations: 2     Fields:    Translation:Humans
    87. Pflugfelder SC, Karpecki PM, Perez VL. Treatment of blepharitis: recent clinical trials. Ocul Surf. 2014 Oct; 12(4):273-84. PMID: 25284773.
      Citations: 14     Fields:    Translation:Humans
    88. Hua X, Yuan X, Tang X, Li Z, Pflugfelder SC, Li DQ. Human corneal epithelial cells produce antimicrobial peptides LL-37 and ß-defensins in response to heat-killed Candida albicans. Ophthalmic Res. 2014; 51(4):179-86. PMID: 24662332.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    89. Foulks GN, Pflugfelder SC. New testing options for diagnosing and grading dry eye disease. Am J Ophthalmol. 2014 Jun; 157(6):1122-9. PMID: 24631478.
      Citations: 7     Fields:    Translation:Humans
    90. Pflugfelder SC. What causes dryness in Sjögren's syndrome patients and how can it be targeted? Expert Rev Clin Immunol. 2014 Apr; 10(4):425-7. PMID: 24564508.
      Citations: 3     Fields:    Translation:Humans
    91. Deng R, Su Z, Lu F, Zhang L, Lin J, Zhang X, de Paiva CS, Pflugfelder SC, Li DQ. A potential link between bacterial pathogens and allergic conjunctivitis by dendritic cells. Exp Eye Res. 2014 Mar; 120:118-26. PMID: 24486456.
      Citations: 4     Fields:    Translation:AnimalsCells
    92. McClellan AJ, Volpe EA, Zhang X, Darlington GJ, Li DQ, Pflugfelder SC, de Paiva CS. Ocular surface disease and dacryoadenitis in aging C57BL/6 mice. Am J Pathol. 2014 Mar; 184(3):631-43. PMID: 24389165.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    93. Chen JJ, Applebaum DS, Sun GS, Pflugfelder SC. Atopic keratoconjunctivitis: A review. J Am Acad Dermatol. 2014 Mar; 70(3):569-75. PMID: 24342754.
      Citations: 19     Fields:    Translation:Humans
    94. Zhang X, De Paiva CS, Su Z, Volpe EA, Li DQ, Pflugfelder SC. Topical interferon-gamma neutralization prevents conjunctival goblet cell loss in experimental murine dry eye. Exp Eye Res. 2014 Jan; 118:117-24. PMID: 24315969.
      Citations: 23     Fields:    Translation:AnimalsCells
    95. Villani E, Baudouin C, Efron N, Hamrah P, Kojima T, Patel SV, Pflugfelder SC, Zhivov A, Dogru M. In vivo confocal microscopy of the ocular surface: from bench to bedside. Curr Eye Res. 2014 Mar; 39(3):213-31. PMID: 24215436.
      Citations: 54     Fields:    Translation:Humans
    96. Coursey TG, Gandhi NB, Volpe EA, Pflugfelder SC, de Paiva CS. Chemokine receptors CCR6 and CXCR3 are necessary for CD4(+) T cell mediated ocular surface disease in experimental dry eye disease. PLoS One. 2013; 8(11):e78508. PMID: 24223818.
      Citations: 19     Fields:    Translation:AnimalsCells
    97. Suhalim JL, Parfitt GJ, Xie Y, De Paiva CS, De Pavia CS, Pflugfelder SC, Shah TN, Potma EO, Brown DJ, Jester JV. Effect of desiccating stress on mouse meibomian gland function. Ocul Surf. 2014 Jan; 12(1):59-68. PMID: 24439047.
      Citations: 19     Fields:    Translation:AnimalsCells
    98. Sheppard JD, Singh R, McClellan AJ, Weikert MP, Scoper SV, Joly TJ, Whitley WO, Kakkar E, Pflugfelder SC. Long-term Supplementation With n-6 and n-3 PUFAs Improves Moderate-to-Severe Keratoconjunctivitis Sicca: A Randomized Double-Blind Clinical Trial. Cornea. 2013 Oct; 32(10):1297-304. PMID: 23884332.
      Citations: 17     Fields:    Translation:Humans
    99. Tung CI, Perin AF, Gumus K, Pflugfelder SC. Tear meniscus dimensions in tear dysfunction and their correlation with clinical parameters. Am J Ophthalmol. 2014 Feb; 157(2):301-310.e1. PMID: 24315297.
      Citations: 17     Fields:    Translation:Humans
    100. Zhang X, Schaumburg CS, Coursey TG, Siemasko KF, Volpe EA, Gandhi NB, Li DQ, Niederkorn JY, Stern ME, Pflugfelder SC, de Paiva CS. CD8? cells regulate the T helper-17 response in an experimental murine model of Sjögren syndrome. Mucosal Immunol. 2014 Mar; 7(2):417-27. PMID: 24022789.
      Citations: 18     Fields:    Translation:AnimalsCells
    101. Pflugfelder SC, Corrales RM, de Paiva CS. T helper cytokines in dry eye disease. Exp Eye Res. 2013 Dec; 117:118-25. PMID: 24012834.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    102. Gandhi NB, Su Z, Zhang X, Volpe EA, Pelegrino FS, Rahman SA, Li DQ, Pflugfelder SC, de Paiva CS. Dendritic cell-derived thrombospondin-1 is critical for the generation of the ocular surface Th17 response to desiccating stress. J Leukoc Biol. 2013 Dec; 94(6):1293-301. PMID: 23983225.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    103. Alex A, Edwards A, Hays JD, Kerkstra M, Shih A, de Paiva CS, Pflugfelder SC. Factors predicting the ocular surface response to desiccating environmental stress. Invest Ophthalmol Vis Sci. 2013 May 07; 54(5):3325-32. PMID: 23572103.
      Citations: 12     Fields:    Translation:HumansCells
    104. Lin J, Zhang L, Zhao G, Su Z, Deng R, Pflugfelder SC, Li DQ. A novel interleukin 33/ST2 signaling regulates inflammatory response in human corneal epithelium. PLoS One. 2013; 8(4):e60963. PMID: 23585867.
      Citations: 13     Fields:    Translation:HumansCells
    105. Henriksson JT, De Paiva CS, Farley W, Pflugfelder SC, Burns AR, Bergmanson JP. Morphologic alterations of the palpebral conjunctival epithelium in a dry eye model. Cornea. 2013 Apr; 32(4):483-90. PMID: 23146932.
      Citations: 3     Fields:    Translation:AnimalsCells
    106. Dimit R, Gire A, Pflugfelder SC, Bergmanson JP. Patient ocular conditions and clinical outcomes using a PROSE scleral device. Cont Lens Anterior Eye. 2013 Aug; 36(4):159-63. PMID: 23499361.
      Citations: 7     Fields:    Translation:Humans
    107. Redfern RL, Patel N, Hanlon S, Farley W, Gondo M, Pflugfelder SC, McDermott AM. Toll-like receptor expression and activation in mice with experimental dry eye. Invest Ophthalmol Vis Sci. 2013 Feb 28; 54(2):1554-63. PMID: 23372055.
      Citations: 16     Fields:    Translation:HumansAnimals
    108. Stern ME, Schaumburg CS, Pflugfelder SC. Dry eye as a mucosal autoimmune disease. Int Rev Immunol. 2013 Feb; 32(1):19-41. PMID: 23360156.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    109. Su Z, Lin J, Lu F, Zhang X, Zhang L, Gandhi NB, de Paiva CS, Pflugfelder SC, Li DQ. Potential autocrine regulation of interleukin-33/ST2 signaling of dendritic cells in allergic inflammation. Mucosal Immunol. 2013 Sep; 6(5):921-30. PMID: 23299617.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    110. Ling JD, Gire A, Pflugfelder SC. PROSE therapy used to minimize corneal trauma in patients with corneal epithelial defects. Am J Ophthalmol. 2013 Apr; 155(4):615-619, 619.e1-2. PMID: 23218704.
      Citations: 4     Fields:    Translation:Humans
    111. Lin J, Yoon KC, Zhang L, Su Z, Lu R, Ma P, De Paiva CS, Pflugfelder SC, Li DQ. A native-like corneal construct using donor corneal stroma for tissue engineering. PLoS One. 2012; 7(11):e49571. PMID: 23166715.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    112. de Paiva CS, Schwartz CE, Gjörstrup P, Pflugfelder SC. Resolvin E1 (RX-10001) reduces corneal epithelial barrier disruption and protects against goblet cell loss in a murine model of dry eye. Cornea. 2012 Nov; 31(11):1299-303. PMID: 22257864.
      Citations: 31     Fields:    Translation:AnimalsCells
    113. Pelegrino FS, Volpe EA, Gandhi NB, Li DQ, Pflugfelder SC, de Paiva CS. Deletion of interferon-? delays onset and severity of dacryoadenitis in CD25KO mice. Arthritis Res Ther. 2012 Nov 01; 14(6):R234. PMID: 23116218.
      Citations: 14     Fields:    Translation:AnimalsCells
    114. Gumus K, Pflugfelder SC. Increasing prevalence and severity of conjunctivochalasis with aging detected by anterior segment optical coherence tomography. Am J Ophthalmol. 2013 Feb; 155(2):238-242.e2. PMID: 23036571.
      Citations: 16     Fields:    Translation:Humans
    115. Lu R, Bian F, Lin J, Su Z, Qu Y, Pflugfelder SC, Li DQ. Identification of human fibroblast cell lines as a feeder layer for human corneal epithelial regeneration. PLoS One. 2012; 7(6):e38825. PMID: 22723892.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    116. Zhang X, Volpe EA, Gandhi NB, Schaumburg CS, Siemasko KF, Pangelinan SB, Kelly SD, Hayday AC, Li DQ, Stern ME, Niederkorn JY, Pflugfelder SC, De Paiva CS. NK cells promote Th-17 mediated corneal barrier disruption in dry eye. PLoS One. 2012; 7(5):e36822. PMID: 22590618.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    117. Stern ME, Schaumburg CS, Siemasko KF, Gao J, Wheeler LA, Grupe DA, De Paiva CS, Calder VL, Calonge M, Niederkorn JY, Pflugfelder SC. Autoantibodies contribute to the immunopathogenesis of experimental dry eye disease. Invest Ophthalmol Vis Sci. 2012 Apr 24; 53(4):2062-75. PMID: 22395876.
      Citations: 22     Fields:    Translation:AnimalsCells
    118. Gumus K, Lee S, Yen MT, Pflugfelder SC. Botulinum toxin injection for the management of refractory filamentary keratitis. Arch Ophthalmol. 2012 Apr; 130(4):446-50. PMID: 22491914.
      Citations: 1     Fields:    Translation:Humans
    119. Lu R, Qu Y, Ge J, Zhang L, Su Z, Pflugfelder SC, Li DQ. Transcription factor TCF4 maintains the properties of human corneal epithelial stem cells. Stem Cells. 2012 Apr; 30(4):753-61. PMID: 22232078.
      Citations: 23     Fields:    Translation:HumansCells
    120. De Paiva CS, Volpe EA, Gandhi NB, Zhang X, Zheng X, Pitcher JD, Farley WJ, Stern ME, Niederkorn JY, Li DQ, Flavell RA, Pflugfelder SC. Disruption of TGF-ß signaling improves ocular surface epithelial disease in experimental autoimmune keratoconjunctivitis sicca. PLoS One. 2011; 6(12):e29017. PMID: 22194977.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    121. Pelegrino FS, Pflugfelder SC, De Paiva CS. Low humidity environmental challenge causes barrier disruption and cornification of the mouse corneal epithelium via a c-jun N-terminal kinase 2 (JNK2) pathway. Exp Eye Res. 2012 Jan; 94(1):150-6. PMID: 22166618.
      Citations: 4     Fields:    Translation:AnimalsCells
    122. Pflugfelder SC, Baudouin C. Challenges in the clinical measurement of ocular surface disease in glaucoma patients. Clin Ophthalmol. 2011; 5:1575-83. PMID: 22125404.
      Citations:    
    123. Chang E, McClellan AJ, Farley WJ, Li DQ, Pflugfelder SC, De Paiva CS. Biodegradable PLGA-Based Drug Delivery Systems for Modulating Ocular Surface Disease under Experimental Murine Dry Eye. J Clin Exp Ophthalmol. 2011 Nov 01; 2(11). PMID: 23560247.
      Citations:    
    124. Pflugfelder SC. Tear dysfunction and the cornea: LXVIII Edward Jackson Memorial Lecture. Am J Ophthalmol. 2011 Dec; 152(6):900-909.e1. PMID: 22019306.
      Citations: 29     Fields:    Translation:Humans
    125. Schaumburg CS, Siemasko KF, De Paiva CS, Wheeler LA, Niederkorn JY, Pflugfelder SC, Stern ME. Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis. J Immunol. 2011 Oct 01; 187(7):3653-62. PMID: 21880984.
      Citations: 45     Fields:    Translation:AnimalsCells
    126. Zhang X, Chen W, De Paiva CS, Volpe EA, Gandhi NB, Farley WJ, Li DQ, Niederkorn JY, Stern ME, Pflugfelder SC. Desiccating stress induces CD4+ T-cell-mediated Sjögren's syndrome-like corneal epithelial apoptosis via activation of the extrinsic apoptotic pathway by interferon-?. Am J Pathol. 2011 Oct; 179(4):1807-14. PMID: 21843497.
      Citations: 27     Fields:    Translation:AnimalsCells
    127. Zhang X, Chen W, De Paiva CS, Corrales RM, Volpe EA, McClellan AJ, Farley WJ, Li DQ, Pflugfelder SC. Interferon-? exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways. Invest Ophthalmol Vis Sci. 2011 Aug 09; 52(9):6279-85. PMID: 21474767.
      Citations: 34     Fields:    Translation:AnimalsCells
    128. Li DQ, Zhang L, Pflugfelder SC, De Paiva CS, Zhang X, Zhao G, Zheng X, Su Z, Qu Y. Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways. J Allergy Clin Immunol. 2011 Dec; 128(6):1318-1325.e2. PMID: 21820713.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    129. Zhang L, Lu R, Zhao G, Pflugfelder SC, Li DQ. TLR-mediated induction of pro-allergic cytokine IL-33 in ocular mucosal epithelium. Int J Biochem Cell Biol. 2011 Sep; 43(9):1383-91. PMID: 21684348.
      Citations: 32     Fields:    Translation:HumansCells
    130. Corrales RM, de Paiva CS, Li DQ, Farley WJ, Henriksson JT, Bergmanson JP, Pflugfelder SC. Entrapment of conjunctival goblet cells by desiccation-induced cornification. Invest Ophthalmol Vis Sci. 2011 Jun 01; 52(6):3492-9. PMID: 21421863.
      Citations: 21     Fields:    Translation:AnimalsCells
    131. Pitcher JD, De Paiva CS, Pelegrino FS, McClellan AJ, Raince JK, Pangelinan SB, Rahimy E, Farley WJ, Stern ME, Li DQ, Pflugfelder SC. Pharmacological cholinergic blockade stimulates inflammatory cytokine production and lymphocytic infiltration in the mouse lacrimal gland. Invest Ophthalmol Vis Sci. 2011 May 16; 52(6):3221-7. PMID: 21273534.
      Citations: 15     Fields:    Translation:AnimalsCells
    132. Lu R, Bian F, Zhang X, Qi H, Chuang EY, Pflugfelder SC, Li DQ. The ß-catenin/Tcf4/survivin signaling maintains a less differentiated phenotype and high proliferative capacity of human corneal epithelial progenitor cells. Int J Biochem Cell Biol. 2011 May; 43(5):751-9. PMID: 21292023.
      Citations: 15     Fields:    Translation:HumansCells
    133. Gumus K, Gire A, Pflugfelder SC. The impact of the Boston ocular surface prosthesis on wavefront higher-order aberrations. Am J Ophthalmol. 2011 Apr; 151(4):682-690.e2. PMID: 21269603.
      Citations: 11     Fields:    Translation:Humans
    134. Gumus K, Crockett CH, Rao K, Yeu E, Weikert MP, Shirayama M, Hada S, Pflugfelder SC. Noninvasive assessment of tear stability with the tear stability analysis system in tear dysfunction patients. Invest Ophthalmol Vis Sci. 2011 Jan; 52(1):456-61. PMID: 20631241.
      Citations: 18     Fields:    Translation:Humans
    135. De Paiva CS, Raince JK, McClellan AJ, Shanmugam KP, Pangelinan SB, Volpe EA, Corrales RM, Farley WJ, Corry DB, Li DQ, Pflugfelder SC. Homeostatic control of conjunctival mucosal goblet cells by NKT-derived IL-13. Mucosal Immunol. 2011 Jul; 4(4):397-408. PMID: 21178983.
      Citations: 34     Fields:    Translation:AnimalsCells
    136. Gumus K, Gire A, Pflugfelder SC. The successful use of Boston ocular surface prosthesis in the treatment of persistent corneal epithelial defect after herpes zoster ophthalmicus. Cornea. 2010 Dec; 29(12):1465-8. PMID: 20847682.
      Citations:    Fields:    Translation:Humans
    137. Bian F, Qi H, Ma P, Zhang L, Yoon KC, Pflugfelder SC, Li DQ. An immunoprotective privilege of corneal epithelial stem cells against Th17 inflammatory stress by producing glial cell-derived neurotrophic factor. Stem Cells. 2010 Dec; 28(12):2172-81. PMID: 20936708.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    138. Gumus K, Crockett CH, Pflugfelder SC. Anterior segment optical coherence tomography: a diagnostic instrument for conjunctivochalasis. Am J Ophthalmol. 2010 Dec; 150(6):798-806. PMID: 20869039.
      Citations: 22     Fields:    Translation:Humans
    139. Qi H, Zheng X, Yuan X, Pflugfelder SC, Li DQ. Potential localization of putative stem/progenitor cells in human bulbar conjunctival epithelium. J Cell Physiol. 2010 Oct; 225(1):180-5. PMID: 20458737.
      Citations: 9     Fields:    Translation:HumansCells
    140. Zheng X, De Paiva CS, Rao K, Li DQ, Farley WJ, Stern M, Pflugfelder SC. Evaluation of the transforming growth factor-beta activity in normal and dry eye human tears by CCL-185 cell bioassay. Cornea. 2010 Sep; 29(9):1048-54. PMID: 20539212.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    141. Haque RM, Torkildsen GL, Brubaker K, Zink RC, Kowalski RP, Mah FS, Pflugfelder SC. Multicenter open-label study evaluating the efficacy of azithromycin ophthalmic solution 1% on the signs and symptoms of subjects with blepharitis. Cornea. 2010 Aug; 29(8):871-7. PMID: 20508503.
      Citations: 16     Fields:    Translation:Humans
    142. Nettune GR, Pflugfelder SC. Post-LASIK tear dysfunction and dysesthesia. Ocul Surf. 2010 Jul; 8(3):135-45. PMID: 20712970.
      Citations: 24     Fields:    Translation:Humans
    143. Rahimy E, Pitcher JD, Pangelinan SB, Chen W, Farley WJ, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC, De Paiva CS. Spontaneous autoimmune dacryoadenitis in aged CD25KO mice. Am J Pathol. 2010 Aug; 177(2):744-53. PMID: 20566743.
      Citations: 16     Fields:    Translation:AnimalsCells
    144. Li DQ, Zhou N, Zhang L, Ma P, Pflugfelder SC. Suppressive effects of azithromycin on zymosan-induced production of proinflammatory mediators by human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2010 Nov; 51(11):5623-9. PMID: 20538995.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    145. Chen Z, Li Z, Basti S, Farley WJ, Pflugfelder SC. Altered morphology and function of the lacrimal functional unit in protein kinase C{alpha} knockout mice. Invest Ophthalmol Vis Sci. 2010 Nov; 51(11):5592-600. PMID: 20505191.
      Citations: 6     Fields:    Translation:Animals
    146. Stern ME, Schaumburg CS, Dana R, Calonge M, Niederkorn JY, Pflugfelder SC. Autoimmunity at the ocular surface: pathogenesis and regulation. Mucosal Immunol. 2010 Sep; 3(5):425-42. PMID: 20485329.
      Citations: 28     Fields:    Translation:HumansAnimals
    147. Bian F, Liu W, Yoon KC, Lu R, Zhou N, Ma P, Pflugfelder SC, Li DQ. Molecular signatures and biological pathway profiles of human corneal epithelial progenitor cells. Int J Biochem Cell Biol. 2010 Jul; 42(7):1142-53. PMID: 20363357.
      Citations: 11     Fields:    Translation:HumansCells
    148. Zheng X, de Paiva CS, Li DQ, Farley WJ, Pflugfelder SC. Desiccating stress promotion of Th17 differentiation by ocular surface tissues through a dendritic cell-mediated pathway. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):3083-91. PMID: 20130281.
      Citations: 40     Fields:    Translation:AnimalsCells
    149. Zheng X, Ma P, de Paiva CS, Cunningham MA, Hwang CS, Pflugfelder SC, Li DQ. TSLP and downstream molecules in experimental mouse allergic conjunctivitis. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):3076-82. PMID: 20107175.
      Citations: 16     Fields:    Translation:AnimalsCells
    150. Zheng X, Bian F, Ma P, De Paiva CS, Stern M, Pflugfelder SC, Li DQ. Induction of Th17 differentiation by corneal epithelial-derived cytokines. J Cell Physiol. 2010 Jan; 222(1):95-102. PMID: 19746420.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    151. Miller KL, Walt JG, Mink DR, Satram-Hoang S, Wilson SE, Perry HD, Asbell PA, Pflugfelder SC. Minimal clinically important difference for the ocular surface disease index. Arch Ophthalmol. 2010 Jan; 128(1):94-101. PMID: 20065224.
      Citations: 84     Fields:    Translation:Humans
    152. De Paiva CS, Hwang CS, Pitcher JD, Pangelinan SB, Rahimy E, Chen W, Yoon KC, Farley WJ, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC. Age-related T-cell cytokine profile parallels corneal disease severity in Sjogren's syndrome-like keratoconjunctivitis sicca in CD25KO mice. Rheumatology (Oxford). 2010 Feb; 49(2):246-58. PMID: 20007286.
      Citations: 39     Fields:    Translation:AnimalsCells
    153. Rao K, Leveque C, Pflugfelder SC. Corneal nerve regeneration in neurotrophic keratopathy following autologous plasma therapy. Br J Ophthalmol. 2010 May; 94(5):584-91. PMID: 19965821.
      Citations: 18     Fields:    Translation:HumansCells
    154. De Paiva CS, Pangelinan SB, Chang E, Yoon KC, Farley WJ, Li DQ, Pflugfelder SC. Essential role for c-Jun N-terminal kinase 2 in corneal epithelial response to desiccating stress. Arch Ophthalmol. 2009 Dec; 127(12):1625-31. PMID: 20008718.
      Citations: 14     Fields:    Translation:AnimalsCells
    155. De Paiva CS, Yoon KC, Pangelinan SB, Pham S, Puthenparambil LM, Chuang EY, Farley WJ, Stern ME, Li DQ, Pflugfelder SC. Cleavage of functional IL-2 receptor alpha chain (CD25) from murine corneal and conjunctival epithelia by MMP-9. J Inflamm (Lond). 2009 Oct 31; 6:31. PMID: 19878594.
      Citations:    
    156. Yoon KC, Park CS, You IC, Choi HJ, Lee KH, Im SK, Park HY, Pflugfelder SC. Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome. Invest Ophthalmol Vis Sci. 2010 Feb; 51(2):643-50. PMID: 19850844.
      Citations: 48     Fields:    Translation:HumansCellsCTClinical Trials
    157. Rao K, Farley WJ, Pflugfelder SC. Association between high tear epidermal growth factor levels and corneal subepithelial fibrosis in dry eye conditions. Invest Ophthalmol Vis Sci. 2010 Feb; 51(2):844-9. PMID: 19815739.
      Citations: 14     Fields:    Translation:Humans
    158. Ma P, Wang Z, Pflugfelder SC, Li DQ. Toll-like receptors mediate induction of peptidoglycan recognition proteins in human corneal epithelial cells. Exp Eye Res. 2010 Jan; 90(1):130-6. PMID: 19799901.
      Citations: 14     Fields:    Translation:Humans
    159. Chen JJ, Rao K, Pflugfelder SC. Corneal epithelial opacity in dysfunctional tear syndrome. Am J Ophthalmol. 2009 Sep; 148(3):376-82. PMID: 19541283.
      Citations: 5     Fields:    Translation:Humans
    160. Yeh S, de Paiva CS, Hwang CS, Trinca K, Lingappan A, Rafati JK, Farley WJ, Li DQ, Pflugfelder SC. Spontaneous T cell mediated keratoconjunctivitis in Aire-deficient mice. Br J Ophthalmol. 2009 Sep; 93(9):1260-4. PMID: 19429577.
      Citations: 8     Fields:    Translation:AnimalsCells
    161. Donnenfeld E, Pflugfelder SC. Topical ophthalmic cyclosporine: pharmacology and clinical uses. Surv Ophthalmol. 2009 May-Jun; 54(3):321-38. PMID: 19422961.
      Citations: 35     Fields:    Translation:Humans
    162. Pflugfelder SC, Stern ME. Immunoregulation on the ocular surface: 2nd Cullen Symposium. Ocul Surf. 2009 Apr; 7(2):67-77. PMID: 19383275.
      Citations: 14     Fields:    Translation:HumansCells
    163. Chotikavanich S, de Paiva CS, Li de Q, Chen JJ, Bian F, Farley WJ, Pflugfelder SC. Production and activity of matrix metalloproteinase-9 on the ocular surface increase in dysfunctional tear syndrome. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3203-9. PMID: 19255163.
      Citations: 94     Fields:    Translation:HumansCells
    164. De Paiva CS, Chotikavanich S, Pangelinan SB, Pitcher JD, Fang B, Zheng X, Ma P, Farley WJ, Siemasko KF, Niederkorn JY, Stern ME, Li DQ, Pflugfelder SC. IL-17 disrupts corneal barrier following desiccating stress. Mucosal Immunol. 2009 May; 2(3):243-53. PMID: 19242409.
      Citations: 145     Fields:    Translation:HumansAnimalsCells
    165. Ma P, Bian F, Wang Z, Zheng X, Chotikavanich S, Pflugfelder SC, Li DQ. Human corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines. Invest Ophthalmol Vis Sci. 2009 Jun; 50(6):2702-9. PMID: 19151401.
      Citations: 26     Fields:    Translation:HumansCells
    166. Lam H, Bleiden L, de Paiva CS, Farley W, Stern ME, Pflugfelder SC. Tear cytokine profiles in dysfunctional tear syndrome. Am J Ophthalmol. 2009 Feb; 147(2):198-205. e1. PMID: 18992869.
      Citations: 132     Fields:    Translation:Humans
    167. de Paiva CS, Pflugfelder SC. Rationale for anti-inflammatory therapy in dry eye syndrome. Arq Bras Oftalmol. 2008 Nov-Dec; 71(6 Suppl):89-95. PMID: 19274418.
      Citations: 25     Fields:    Translation:Humans
    168. Qi H, Shine HD, Li DQ, de Paiva CS, Farley WJ, Jones DB, Pflugfelder SC. Glial cell-derived neurotrophic factor gene delivery enhances survival of human corneal epithelium in culture and the overexpression of GDNF in bioengineered constructs. Exp Eye Res. 2008 Dec; 87(6):580-6. PMID: 18938159.
      Citations: 6     Fields:    Translation:HumansCells
    169. Qi H, Li DQ, Bian F, Chuang EY, Jones DB, Pflugfelder SC. Expression of glial cell-derived neurotrophic factor and its receptor in the stem-cell-containing human limbal epithelium. Br J Ophthalmol. 2008 Sep; 92(9):1269-74. PMID: 18723744.
      Citations: 10     Fields:    Translation:HumansCells
    170. Pflugfelder SC, de Paiva CS, Li DQ, Stern ME. Epithelial-immune cell interaction in dry eye. Cornea. 2008 Sep; 27 Suppl 1:S9-11. PMID: 18813079.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    171. Beardsley RM, De Paiva CS, Power DF, Pflugfelder SC. Desiccating stress decreases apical corneal epithelial cell size--modulation by the metalloproteinase inhibitor doxycycline. Cornea. 2008 Sep; 27(8):935-40. PMID: 18724157.
      Citations: 14     Fields:    Translation:AnimalsCells
    172. Chuang EY, Li DQ, Bian F, Zheng X, Pflugfelder SC. Effects of contact lens multipurpose solutions on human corneal epithelial survival and barrier function. Eye Contact Lens. 2008 Sep; 34(5):281-6. PMID: 18779668.
      Citations: 8     Fields:    Translation:HumansCells
    173. Narayanan S, Corrales RM, Farley W, McDermott AM, Pflugfelder SC. Interleukin-1 receptor-1-deficient mice show attenuated production of ocular surface inflammatory cytokines in experimental dry eye. Cornea. 2008 Aug; 27(7):811-7. PMID: 18650668.
      Citations: 19     Fields:    Translation:Animals
    174. Siemasko KF, Gao J, Calder VL, Hanna R, Calonge M, Pflugfelder SC, Niederkorn JY, Stern ME. In vitro expanded CD4+CD25+Foxp3+ regulatory T cells maintain a normal phenotype and suppress immune-mediated ocular surface inflammation. Invest Ophthalmol Vis Sci. 2008 Dec; 49(12):5434-40. PMID: 18658093.
      Citations: 23     Fields:    Translation:AnimalsCells
    175. Corrales RM, Luo L, Chang EY, Pflugfelder SC. Effects of osmoprotectants on hyperosmolar stress in cultured human corneal epithelial cells. Cornea. 2008 Jun; 27(5):574-9. PMID: 18520508.
      Citations: 38     Fields:    Translation:HumansCells
    176. Pflugfelder SC. Prevalence, burden, and pharmacoeconomics of dry eye disease. Am J Manag Care. 2008 Apr; 14(3 Suppl):S102-6. PMID: 18452369.
      Citations: 58     Fields:    Translation:Humans
    177. Chen Z, Tong L, Li Z, Yoon KC, Qi H, Farley W, Li DQ, Pflugfelder SC. Hyperosmolarity-induced cornification of human corneal epithelial cells is regulated by JNK MAPK. Invest Ophthalmol Vis Sci. 2008 Feb; 49(2):539-49. PMID: 18234997.
      Citations: 29     Fields:    Translation:HumansCells
    178. Wilhelmus KR, Jones DB, Matoba AY, Hamill MB, Pflugfelder SC, Weikert MP. Bilateral acanthamoeba keratitis. Am J Ophthalmol. 2008 Feb; 145(2):193-197. PMID: 18222188.
      Citations: 7     Fields:    Translation:Humans
    179. Pflugfelder SC, De Paiva CS, Villarreal AL, Stern ME. Effects of sequential artificial tear and cyclosporine emulsion therapy on conjunctival goblet cell density and transforming growth factor-beta2 production. Cornea. 2008 Jan; 27(1):64-9. PMID: 18245969.
      Citations: 41     Fields:    Translation:HumansCells
    180. Yoon KC, De Paiva CS, Qi H, Chen Z, Farley WJ, Li DQ, Stern ME, Pflugfelder SC. Desiccating environmental stress exacerbates autoimmune lacrimal keratoconjunctivitis in non-obese diabetic mice. J Autoimmun. 2008 Jun; 30(4):212-21. PMID: 17988834.
      Citations: 14     Fields:    Translation:AnimalsCells
    181. Qi H, Chuang EY, Yoon KC, de Paiva CS, Shine HD, Jones DB, Pflugfelder SC, Li DQ. Patterned expression of neurotrophic factors and receptors in human limbal and corneal regions. Mol Vis. 2007 Oct 16; 13:1934-41. PMID: 17982417.
      Citations: 26     Fields:    Translation:Humans
    182. Pflugfelder SC, Stern ME. Future directions in therapeutic interventions for conjunctival inflammatory disorders. Curr Opin Allergy Clin Immunol. 2007 Oct; 7(5):450-3. PMID: 17873588.
      Citations: 2     Fields:    Translation:HumansAnimals
    183. Qi H, Li DQ, Shine HD, Chen Z, Yoon KC, Jones DB, Pflugfelder SC. Nerve growth factor and its receptor TrkA serve as potential markers for human corneal epithelial progenitor cells. Exp Eye Res. 2008 Jan; 86(1):34-40. PMID: 17980361.
      Citations: 33     Fields:    Translation:HumansCells
    184. De Paiva CS, Villarreal AL, Corrales RM, Rahman HT, Chang VY, Farley WJ, Stern ME, Niederkorn JY, Li DQ, Pflugfelder SC. Dry eye-induced conjunctival epithelial squamous metaplasia is modulated by interferon-gamma. Invest Ophthalmol Vis Sci. 2007 Jun; 48(6):2553-60. PMID: 17525184.
      Citations: 107     Fields:    Translation:AnimalsCells
    185. Yoon KC, De Paiva CS, Qi H, Chen Z, Farley WJ, Li DQ, Pflugfelder SC. Expression of Th-1 chemokines and chemokine receptors on the ocular surface of C57BL/6 mice: effects of desiccating stress. Invest Ophthalmol Vis Sci. 2007 Jun; 48(6):2561-9. PMID: 17525185.
      Citations: 72     Fields:    Translation:AnimalsCells
    186. Corrales RM, Villarreal A, Farley W, Stern ME, Li DQ, Pflugfelder SC. Strain-related cytokine profiles on the murine ocular surface in response to desiccating stress. Cornea. 2007 Jun; 26(5):579-84. PMID: 17525655.
      Citations: 36     Fields:    Translation:AnimalsCells
    187. Luo L, Li DQ, Pflugfelder SC. Hyperosmolarity-induced apoptosis in human corneal epithelial cells is mediated by cytochrome c and MAPK pathways. Cornea. 2007 May; 26(4):452-60. PMID: 17457195.
      Citations: 43     Fields:    Translation:HumansCells
    188. Parghi C, McKnight GT, Pflugfelder SC. Prominent corneal nerves in a patient with multiple myeloma. Cornea. 2007 Feb; 26(2):220-2. PMID: 17251817.
      Citations: 4     Fields:    Translation:Humans
    189. Villareal AL, Farley W, Pflugfelder SC. Effect of topical ophthalmic epinastine and olopatadine on tear volume in mice. Eye Contact Lens. 2006 Dec; 32(6):272-6. PMID: 17099387.
      Citations: 12     Fields:    Translation:Animals
    190. Tong L, Chen Z, De Paiva CS, Beuerman R, Li DQ, Pflugfelder SC. Transglutaminase participates in UVB-induced cell death pathways in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2006 Oct; 47(10):4295-301. PMID: 17003418.
      Citations: 6     Fields:    Translation:HumansCells
    191. Behrens A, Doyle JJ, Stern L, Chuck RS, McDonnell PJ, Azar DT, Dua HS, Hom M, Karpecki PM, Laibson PR, Lemp MA, Meisler DM, Del Castillo JM, O'Brien TP, Pflugfelder SC, Rolando M, Schein OD, Seitz B, Tseng SC, van Setten G, Wilson SE, Yiu SC. Dysfunctional tear syndrome: a Delphi approach to treatment recommendations. Cornea. 2006 Sep; 25(8):900-7. PMID: 17102664.
      Citations: 112     Fields:    Translation:Humans
    192. Chen Z, Li DQ, Tong L, Stewart P, Chu C, Pflugfelder SC. Targeted inhibition of p57 and p15 blocks transforming growth factor beta-inhibited proliferation of primary cultured human limbal epithelial cells. Mol Vis. 2006 Aug 23; 12:983-94. PMID: 16943770.
      Citations: 10     Fields:    Translation:HumansCells
    193. Corrales RM, Stern ME, De Paiva CS, Welch J, Li DQ, Pflugfelder SC. Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium. Invest Ophthalmol Vis Sci. 2006 Aug; 47(8):3293-302. PMID: 16877394.
      Citations: 57     Fields:    Translation:AnimalsCells
    194. Pflugfelder SC. Is autologous serum a tonic for the ailing corneal epithelium? Am J Ophthalmol. 2006 Aug; 142(2):316-7. PMID: 16876515.
      Citations: 19     Fields:    Translation:Humans
    195. De Paiva CS, Corrales RM, Villarreal AL, Farley W, Li DQ, Stern ME, Pflugfelder SC. Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline. Invest Ophthalmol Vis Sci. 2006 Jul; 47(7):2847-56. PMID: 16799024.
      Citations: 65     Fields:    Translation:Animals
    196. Chen Z, Mok H, Pflugfelder SC, Li DQ, Barry MA. Improved transduction of human corneal epithelial progenitor cells with cell-targeting adenoviral vectors. Exp Eye Res. 2006 Oct; 83(4):798-806. PMID: 16793039.
      Citations: 6     Fields:    Translation:HumansCells
    197. Tong L, Corrales RM, Chen Z, Villarreal AL, De Paiva CS, Beuerman R, Li DQ, Pflugfelder SC. Expression and regulation of cornified envelope proteins in human corneal epithelium. Invest Ophthalmol Vis Sci. 2006 May; 47(5):1938-46. PMID: 16639001.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    198. De Paiva CS, Corrales RM, Villarreal AL, Farley WJ, Li DQ, Stern ME, Pflugfelder SC. Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye. Exp Eye Res. 2006 Sep; 83(3):526-35. PMID: 16643899.
      Citations: 118     Fields:    Translation:AnimalsCells
    199. Niederkorn JY, Stern ME, Pflugfelder SC, De Paiva CS, Corrales RM, Gao J, Siemasko K. Desiccating stress induces T cell-mediated Sjögren's Syndrome-like lacrimal keratoconjunctivitis. J Immunol. 2006 Apr 01; 176(7):3950-7. PMID: 16547229.
      Citations: 120     Fields:    Translation:AnimalsCells
    200. De Paiva CS, Chen Z, Koch DD, Hamill MB, Manuel FK, Hassan SS, Wilhelmus KR, Pflugfelder SC. The incidence and risk factors for developing dry eye after myopic LASIK. Am J Ophthalmol. 2006 Mar; 141(3):438-45. PMID: 16490488.
      Citations: 45     Fields:    Translation:Humans
    201. Chen Z, Evans WH, Pflugfelder SC, Li DQ. Gap junction protein connexin 43 serves as a negative marker for a stem cell-containing population of human limbal epithelial cells. Stem Cells. 2006 May; 24(5):1265-73. PMID: 16424398.
      Citations: 35     Fields:    Translation:HumansCells
    202. Pflugfelder SC. Integrating restasis into the management of dry eye. Int Ophthalmol Clin. 2006; 46(4):101-3. PMID: 17060796.
      Citations: 2     Fields:    Translation:Humans
    203. Li DQ, Luo L, Chen Z, Kim HS, Song XJ, Pflugfelder SC. JNK and ERK MAP kinases mediate induction of IL-1beta, TNF-alpha and IL-8 following hyperosmolar stress in human limbal epithelial cells. Exp Eye Res. 2006 Apr; 82(4):588-96. PMID: 16202406.
      Citations: 101     Fields:    Translation:HumansCells
    204. McDermott AM, Perez V, Huang AJ, Pflugfelder SC, Stern ME, Baudouin C, Beuerman RW, Burns AR, Calder VL, Calonge M, Chodosh J, Coster DJ, Dana R, Hazlett LD, Jones DB, Kim SK, Knop E, Li DQ, Mitchell BM, Niederkorn JY, Pearlman E, Wilhelmus KR, Kurie E. Pathways of corneal and ocular surface inflammation: a perspective from the cullen symposium. Ocul Surf. 2005 Oct; 3(4 Suppl):S131-8. PMID: 17216102.
      Citations: 16     Fields:    
    205. Li DQ, Pflugfelder SC. Matrix metalloproteinases in corneal inflammation. Ocul Surf. 2005 Oct; 3(4 Suppl):S198-202. PMID: 17216119.
      Citations: 15     Fields:    
    206. Stern ME, Siemasko KF, Gao J, Calonge M, Niederkorn JY, Pflugfelder SC. Evaluation of ocular surface inflammation in the presence of dry eye and allergic conjunctival disease. Ocul Surf. 2005 Oct; 3(4 Suppl):S161-4. PMID: 17216110.
      Citations: 11     Fields:    
    207. Barber LD, Pflugfelder SC, Tauber J, Foulks GN. Phase III safety evaluation of cyclosporine 0.1% ophthalmic emulsion administered twice daily to dry eye disease patients for up to 3 years. Ophthalmology. 2005 Oct; 112(10):1790-4. PMID: 16102833.
      Citations: 32     Fields:    Translation:HumansCTClinical Trials
    208. Pflugfelder SC, de Paiva CS, Tong L, Luo L, Stern ME, Li DQ. Stress-activated protein kinase signaling pathways in dry eye and ocular surface disease. Ocul Surf. 2005 Oct; 3(4 Suppl):S154-7. PMID: 17216108.
      Citations: 14     Fields:    
    209. Luo L, Li DQ, Corrales RM, Pflugfelder SC. Hyperosmolar saline is a proinflammatory stress on the mouse ocular surface. Eye Contact Lens. 2005 Sep; 31(5):186-93. PMID: 16163009.
      Citations: 82     Fields:    Translation:AnimalsCells
    210. De Paiva CS, Pflugfelder SC, Li DQ. Cell size correlates with phenotype and proliferative capacity in human corneal epithelial cells. Stem Cells. 2006 Feb; 24(2):368-75. PMID: 16123387.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    211. Thomas JW, Pflugfelder SC. Therapy of progressive rheumatoid arthritis-associated corneal ulceration with infliximab. Cornea. 2005 Aug; 24(6):742-4. PMID: 16015096.
      Citations: 18     Fields:    Translation:Humans
    212. Stewart P, Chen Z, Farley W, Olmos L, Pflugfelder SC. Effect of experimental dry eye on tear sodium concentration in the mouse. Eye Contact Lens. 2005 Jul; 31(4):175-8. PMID: 16021005.
      Citations: 17     Fields:    Translation:Animals
    213. Li DQ, Chen Z, Song XJ, de Paiva CS, Kim HS, Pflugfelder SC. Partial enrichment of a population of human limbal epithelial cells with putative stem cell properties based on collagen type IV adhesiveness. Exp Eye Res. 2005 Apr; 80(4):581-90. PMID: 15781286.
      Citations: 30     Fields:    Translation:HumansCells
    214. Kim HS, Luo L, Pflugfelder SC, Li DQ. Doxycycline inhibits TGF-beta1-induced MMP-9 via Smad and MAPK pathways in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2005 Mar; 46(3):840-8. PMID: 15728539.
      Citations: 40     Fields:    Translation:HumansCells
    215. Strong B, Farley W, Stern ME, Pflugfelder SC. Topical cyclosporine inhibits conjunctival epithelial apoptosis in experimental murine keratoconjunctivitis sicca. Cornea. 2005 Jan; 24(1):80-5. PMID: 15604871.
      Citations: 38     Fields:    Translation:AnimalsCells
    216. Pflugfelder SC, Farley W, Luo L, Chen LZ, de Paiva CS, Olmos LC, Li DQ, Fini ME. Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye. Am J Pathol. 2005 Jan; 166(1):61-71. PMID: 15632000.
      Citations: 91     Fields:    Translation:AnimalsCells
    217. de Paiva CS, Chen Z, Corrales RM, Pflugfelder SC, Li DQ. ABCG2 transporter identifies a population of clonogenic human limbal epithelial cells. Stem Cells. 2005; 23(1):63-73. PMID: 15625123.
      Citations: 93     Fields:    Translation:HumansAnimalsCells
    218. Li DQ, Chen Z, Song XJ, Luo L, Pflugfelder SC. Stimulation of matrix metalloproteinases by hyperosmolarity via a JNK pathway in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2004 Dec; 45(12):4302-11. PMID: 15557436.
      Citations: 83     Fields:    Translation:HumansCells
    219. Luo L, Li DQ, Doshi A, Farley W, Corrales RM, Pflugfelder SC. Experimental dry eye stimulates production of inflammatory cytokines and MMP-9 and activates MAPK signaling pathways on the ocular surface. Invest Ophthalmol Vis Sci. 2004 Dec; 45(12):4293-301. PMID: 15557435.
      Citations: 174     Fields:    Translation:AnimalsCells
    220. Seth RK, Su GW, Pflugfelder SC. Mucous membrane pemphigoid in a patient with chronic lymphocytic leukemia. Cornea. 2004 Oct; 23(7):740-3. PMID: 15448507.
      Citations: 2     Fields:    Translation:Humans
    221. Pflugfelder SC, Maskin SL, Anderson B, Chodosh J, Holland EJ, De Paiva CS, Bartels SP, Micuda T, Proskin HM, Vogel R. A randomized, double-masked, placebo-controlled, multicenter comparison of loteprednol etabonate ophthalmic suspension, 0.5%, and placebo for treatment of keratoconjunctivitis sicca in patients with delayed tear clearance. Am J Ophthalmol. 2004 Sep; 138(3):444-57. PMID: 15364229.
      Citations: 53     Fields:    Translation:HumansCTClinical Trials
    222. Kim HS, Shang T, Chen Z, Pflugfelder SC, Li DQ. TGF-beta1 stimulates production of gelatinase (MMP-9), collagenases (MMP-1, -13) and stromelysins (MMP-3, -10, -11) by human corneal epithelial cells. Exp Eye Res. 2004 Aug; 79(2):263-74. PMID: 15325573.
      Citations: 28     Fields:    Translation:HumansCells
    223. Kim HS, Jun Song X, de Paiva CS, Chen Z, Pflugfelder SC, Li DQ. Phenotypic characterization of human corneal epithelial cells expanded ex vivo from limbal explant and single cell cultures. Exp Eye Res. 2004 Jul; 79(1):41-9. PMID: 15183099.
      Citations: 80     Fields:    Translation:HumansCells
    224. Stern ME, Pflugfelder SC. Inflammation in dry eye. Ocul Surf. 2004 Apr; 2(2):124-30. PMID: 17216083.
      Citations: 49     Fields:    
    225. Stern ME, Gao J, Siemasko KF, Beuerman RW, Pflugfelder SC. The role of the lacrimal functional unit in the pathophysiology of dry eye. Exp Eye Res. 2004 Mar; 78(3):409-16. PMID: 15106920.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    226. de Paiva CS, Pflugfelder SC. Tear clearance implications for ocular surface health. Exp Eye Res. 2004 Mar; 78(3):395-7. PMID: 15106918.
      Citations: 6     Fields:    Translation:Humans
    227. Pflugfelder SC. Hormonal deficiencies and dry eye. Arch Ophthalmol. 2004 Feb; 122(2):273-4. PMID: 14769606.
      Citations:    Fields:    Translation:Humans
    228. Pflugfelder SC. Antiinflammatory therapy for dry eye. Am J Ophthalmol. 2004 Feb; 137(2):337-42. PMID: 14962426.
      Citations: 99     Fields:    Translation:Humans
    229. Chen Z, de Paiva CS, Luo L, Kretzer FL, Pflugfelder SC, Li DQ. Characterization of putative stem cell phenotype in human limbal epithelia. Stem Cells. 2004; 22(3):355-66. PMID: 15153612.
      Citations: 144     Fields:    Translation:HumansCells
    230. Hernandez-Illas M, Tozman E, Fulcher SF, Jundt JW, Davis J, Pflugfelder SC. Recombinant human tumor necrosis factor receptor Fc fusion protein (Etanercept): experience as a therapy for sight-threatening scleritis and sterile corneal ulceration. Eye Contact Lens. 2004 Jan; 30(1):2-5. PMID: 14722460.
      Citations: 6     Fields:    Translation:Humans
    231. De Paiva CS, Pflugfelder SC. Corneal epitheliopathy of dry eye induces hyperesthesia to mechanical air jet stimulation. Am J Ophthalmol. 2004 Jan; 137(1):109-15. PMID: 14700652.
      Citations: 42     Fields:    Translation:HumansCells
    232. Song XJ, Li DQ, Farley W, Luo LH, Heuckeroth RO, Milbrandt J, Pflugfelder SC. Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 2003 Oct; 44(10):4223-9. PMID: 14507865.
      Citations: 29     Fields:    Translation:AnimalsCells
    233. Wall V, Yen MT, Yang MC, Huang AJ, Pflugfelder SC. Management of the late ocular sequelae of Stevens-Johnson syndrome. Ocul Surf. 2003 Oct; 1(4):192-201. PMID: 17075650.
      Citations: 1     Fields:    
    234. Solomon R, Donnenfeld ED, Azar DT, Holland EJ, Palmon FR, Pflugfelder SC, Rubenstein JB. Infectious keratitis after laser in situ keratomileusis: results of an ASCRS survey. J Cataract Refract Surg. 2003 Oct; 29(10):2001-6. PMID: 14604725.
      Citations: 10     Fields:    Translation:HumansCells
    235. Li DQ, Shang TY, Kim HS, Solomon A, Lokeshwar BL, Pflugfelder SC. Regulated expression of collagenases MMP-1, -8, and -13 and stromelysins MMP-3, -10, and -11 by human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2003 Jul; 44(7):2928-36. PMID: 12824233.
      Citations: 27     Fields:    Translation:HumansCells
    236. de Paiva CS, Lindsey JL, Pflugfelder SC. Assessing the severity of keratitis sicca with videokeratoscopic indices. Ophthalmology. 2003 Jun; 110(6):1102-9. PMID: 12799233.
      Citations: 22     Fields:    Translation:Humans
    237. Pflugfelder SC. The Ocular Surface Center at the Baylor College of Medicine, Houston. Ocul Surf. 2003 Apr; 1(2):89-90. PMID: 17075639.
      Citations:    Fields:    
    238. Karp CL, Tuli SS, Yoo SH, Vroman DT, Alfonso EC, Huang AH, Pflugfelder SC, Culbertson WW. Infectious keratitis after LASIK. Ophthalmology. 2003 Mar; 110(3):503-10. PMID: 12623812.
      Citations: 12     Fields:    Translation:HumansCells
    239. Yeh S, Song XJ, Farley W, Li DQ, Stern ME, Pflugfelder SC. Apoptosis of ocular surface cells in experimentally induced dry eye. Invest Ophthalmol Vis Sci. 2003 Jan; 44(1):124-9. PMID: 12506064.
      Citations: 69     Fields:    Translation:AnimalsCells
    240. De Paiva CS, Harris LD, Pflugfelder SC. Keratoconus-like topographic changes in keratoconjunctivitis sicca. Cornea. 2003 Jan; 22(1):22-4. PMID: 12502943.
      Citations: 3     Fields:    Translation:Humans
    241. Pflugfelder SC. Anti-inflammatory therapy of dry eye. Ocul Surf. 2003 Jan; 1(1):31-6. PMID: 17075627.
      Citations: 13     Fields:    
    242. Pflugfelder SC, Liu Z, Feuer W, Verm A. Corneal thickness indices discriminate between keratoconus and contact lens-induced corneal thinning. Ophthalmology. 2002 Dec; 109(12):2336-41. PMID: 12466180.
      Citations: 23     Fields:    Translation:Humans
    243. Dursun D, Wang M, Monroy D, Li DQ, Lokeshwar BL, Stern ME, Pflugfelder SC. A mouse model of keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 2002 Mar; 43(3):632-8. PMID: 11867577.
      Citations: 73     Fields:    Translation:AnimalsCells
    244. Pflugfelder SC, Solomon A, Dursun D, Li DQ. Dry eye and delayed tear clearance: "a call to arms.". Adv Exp Med Biol. 2002; 506(Pt B):739-43. PMID: 12613986.
      Citations: 5     Fields:    Translation:HumansAnimals
    245. Dursun D, Wang M, Monroy D, Li DQ, Lokeshwar BL, Stern M, Pflugfelder SC. Experimentally induced dry eye produces ocular surface inflammation and epithelial disease. Adv Exp Med Biol. 2002; 506(Pt A):647-55. PMID: 12613973.
      Citations: 14     Fields:    Translation:AnimalsCells
    246. Li DQ, Lokeshwar BL, Solomon A, Monroy D, Ji Z, Pflugfelder SC. Regulation of MMP-9 production by human corneal epithelial cells. Exp Eye Res. 2001 Oct; 73(4):449-59. PMID: 11825017.
      Citations: 59     Fields:    Translation:Humans
    247. Solomon A, Dursun D, Liu Z, Xie Y, Macri A, Pflugfelder SC. Pro- and anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease. Invest Ophthalmol Vis Sci. 2001 Sep; 42(10):2283-92. PMID: 11527941.
      Citations: 175     Fields:    Translation:Humans
    248. Dursun D, Piniella AM, Pflugfelder SC. Pseudokeratoconus caused by rosacea. Cornea. 2001 Aug; 20(6):668-9. PMID: 11473174.
      Citations: 6     Fields:    Translation:Humans
    249. Battat L, Macri A, Dursun D, Pflugfelder SC. Effects of laser in situ keratomileusis on tear production, clearance, and the ocular surface. Ophthalmology. 2001 Jul; 108(7):1230-5. PMID: 11425680.
      Citations: 46     Fields:    Translation:Humans
    250. Dursun D, Kim MC, Solomon A, Pflugfelder SC. Treatment of recalcitrant recurrent corneal erosions with inhibitors of matrix metalloproteinase-9, doxycycline and corticosteroids. Am J Ophthalmol. 2001 Jul; 132(1):8-13. PMID: 11438047.
      Citations: 33     Fields:    Translation:Humans
    251. Solomon A, Rosenblatt M, Monroy D, Ji Z, Pflugfelder SC, Tseng SC. Suppression of interleukin 1alpha and interleukin 1beta in human limbal epithelial cells cultured on the amniotic membrane stromal matrix. Br J Ophthalmol. 2001 Apr; 85(4):444-9. PMID: 11264135.
      Citations: 61     Fields:    Translation:HumansCells
    252. Yen MT, Pflugfelder SC, Feuer WJ. The effect of punctal occlusion on tear production, tear clearance, and ocular surface sensation in normal subjects. Am J Ophthalmol. 2001 Mar; 131(3):314-23. PMID: 11239863.
      Citations: 11     Fields:    Translation:Humans
    253. Liu Z, Carvajal M, Carraway CA, Carraway K, Pflugfelder SC. Expression of the receptor tyrosine kinases, epidermal growth factor receptor, ErbB2, and ErbB3, in human ocular surface epithelia. Cornea. 2001 Jan; 20(1):81-5. PMID: 11189010.
      Citations: 19     Fields:    Translation:HumansAnimals
    254. Macri A, Pflugfelder S. Correlation of the Schirmer 1 and fluorescein clearance tests with the severity of corneal epithelial and eyelid disease. Arch Ophthalmol. 2000 Dec; 118(12):1632-8. PMID: 11115257.
      Citations: 17     Fields:    Translation:Humans
    255. Pflugfelder SC, Solomon A, Stern ME. The diagnosis and management of dry eye: a twenty-five-year review. Cornea. 2000 Sep; 19(5):644-9. PMID: 11009316.
      Citations: 62     Fields:    Translation:HumansAnimals
    256. Dursun D, Monroy D, Knighton R, Tervo T, Vesaluoma M, Carraway K, Feuer W, Pflugfelder SC. The effects of experimental tear film removal on corneal surface regularity and barrier function. Ophthalmology. 2000 Sep; 107(9):1754-60. PMID: 10964840.
      Citations: 18     Fields:    Translation:Humans
    257. Liu Z, Xie Y, Zhang M, Pflugfelder SC. [The abnormal expression of epidermal growth factor receptor family in pterygium]. Zhonghua Yan Ke Za Zhi. 2000 Sep; 36(5):372-4, 25. PMID: 11853633.
      Citations:    Fields:    Translation:Humans
    258. Solomon A, Rosenblatt M, Li DQ, Liu Z, Monroy D, Ji Z, Lokeshwar BL, Pflugfelder SC. Doxycycline inhibition of interleukin-1 in the corneal epithelium. Invest Ophthalmol Vis Sci. 2000 Aug; 41(9):2544-57. PMID: 10937565.
      Citations: 29     Fields:    Translation:HumansCells
    259. Macri A, Rolando M, Pflugfelder S. A standardized visual scale for evaluation of tear fluorescein clearance. Ophthalmology. 2000 Jul; 107(7):1338-43. PMID: 10889108.
      Citations: 17     Fields:    Translation:Humans
    260. Wang MX, Shen DJ, Liu JC, Pflugfelder SC, Alfonso EC, Forster RK. Recurrent fungal keratitis and endophthalmitis. Cornea. 2000 Jul; 19(4):558-60. PMID: 10928778.
      Citations: 5     Fields:    Translation:HumansAnimalsPHPublic Health
    261. Turner K, Pflugfelder SC, Ji Z, Feuer WJ, Stern M, Reis BL. Interleukin-6 levels in the conjunctival epithelium of patients with dry eye disease treated with cyclosporine ophthalmic emulsion. Cornea. 2000 Jul; 19(4):492-6. PMID: 10928765.
      Citations: 38     Fields:    Translation:HumansCTClinical Trials
    262. Sobrin L, Liu Z, Monroy DC, Solomon A, Selzer MG, Lokeshwar BL, Pflugfelder SC. Regulation of MMP-9 activity in human tear fluid and corneal epithelial culture supernatant. Invest Ophthalmol Vis Sci. 2000 Jun; 41(7):1703-9. PMID: 10845589.
      Citations: 33     Fields:    Translation:HumansCells
    263. Pflugfelder SC, Liu Z, Monroy D, Li DQ, Carvajal ME, Price-Schiavi SA, Idris N, Solomon A, Perez A, Carraway KL. Detection of sialomucin complex (MUC4) in human ocular surface epithelium and tear fluid. Invest Ophthalmol Vis Sci. 2000 May; 41(6):1316-26. PMID: 10798646.
      Citations: 36     Fields:    Translation:Humans
    264. Liu Z, Carvajal M, Carothers Carraway CA, Carraway KL, Pflugfelder SC. Increased expression of the type 1 growth factor receptor family in the conjunctival epithelium of patients with keratoconjunctivitis sicca. Am J Ophthalmol. 2000 Apr; 129(4):472-80. PMID: 10764856.
      Citations: 6     Fields:    Translation:Humans
    265. Liu Z, Xie Y, Zhang M, Pflugfelder SC. [The effect of artificial tears on corneal surface regularity in dry eye]. Zhonghua Yan Ke Za Zhi. 2000 Mar; 36(2):131-4. PMID: 11853602.
      Citations:    Fields:    Translation:Humans
    266. Liu Z, Pflugfelder SC. The effects of long-term contact lens wear on corneal thickness, curvature, and surface regularity. Ophthalmology. 2000 Jan; 107(1):105-11. PMID: 10647727.
      Citations: 24     Fields:    Translation:Humans
    267. Afonso AA, Sobrin L, Monroy DC, Selzer M, Lokeshwar B, Pflugfelder SC. Tear fluid gelatinase B activity correlates with IL-1alpha concentration and fluorescein clearance in ocular rosacea. Invest Ophthalmol Vis Sci. 1999 Oct; 40(11):2506-12. PMID: 10509643.
      Citations: 46     Fields:    Translation:Humans
    268. Pflugfelder SC, Jones D, Ji Z, Afonso A, Monroy D. Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjögren's syndrome keratoconjunctivitis sicca. Curr Eye Res. 1999 Sep; 19(3):201-11. PMID: 10487957.
      Citations: 140     Fields:    Translation:HumansCells
    269. Liu Z, Pflugfelder SC. Corneal thickness is reduced in dry eye. Cornea. 1999 Jul; 18(4):403-7. PMID: 10422850.
      Citations: 28     Fields:    Translation:Humans
    270. Liu Z, Huang AJ, Pflugfelder SC. Evaluation of corneal thickness and topography in normal eyes using the Orbscan corneal topography system. Br J Ophthalmol. 1999 Jul; 83(7):774-8. PMID: 10381661.
      Citations: 32     Fields:    Translation:Humans
    271. Liu Z, Pflugfelder SC. Corneal surface regularity and the effect of artificial tears in aqueous tear deficiency. Ophthalmology. 1999 May; 106(5):939-43. PMID: 10328393.
      Citations: 33     Fields:    Translation:HumansCTClinical Trials
    272. Afonso AA, Monroy D, Stern ME, Feuer WJ, Tseng SC, Pflugfelder SC. Correlation of tear fluorescein clearance and Schirmer test scores with ocular irritation symptoms. Ophthalmology. 1999 Apr; 106(4):803-10. PMID: 10201606.
      Citations: 45     Fields:    Translation:Humans
    273. Marsh P, Pflugfelder SC. Topical nonpreserved methylprednisolone therapy for keratoconjunctivitis sicca in Sjögren syndrome. Ophthalmology. 1999 Apr; 106(4):811-6. PMID: 10201607.
      Citations: 57     Fields:    Translation:HumansCTClinical Trials
    274. Stern ME, Beuerman RW, Fox RI, Gao J, Mircheff AK, Pflugfelder SC. The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea. 1998 Nov; 17(6):584-9. PMID: 9820935.
      Citations: 152     Fields:    Translation:HumansAnimalsCells
    275. Ford JG, Huang AJ, Pflugfelder SC, Alfonso EC, Forster RK, Miller D. Nontuberculous mycobacterial keratitis in south Florida. Ophthalmology. 1998 Sep; 105(9):1652-8. PMID: 9754173.
      Citations: 13     Fields:    Translation:HumansCells
    276. Demirbas NH, Pflugfelder SC. Topographic pattern and apex location of keratoconus on elevation topography maps. Cornea. 1998 Sep; 17(5):476-84. PMID: 9756441.
      Citations: 4     Fields:    Translation:Humans
    277. Pflugfelder SC. Advances in the diagnosis and management of keratoconjunctivitis sicca. Curr Opin Ophthalmol. 1998 Aug; 9(4):50-3. PMID: 10387469.
      Citations: 2     Fields:    Translation:HumansAnimals
    278. Stern ME, Beuerman RW, Fox RI, Gao J, Mircheff AK, Pflugfelder SC. A unified theory of the role of the ocular surface in dry eye. Adv Exp Med Biol. 1998; 438:643-51. PMID: 9634949.
      Citations: 26     Fields:    Translation:HumansAnimals
    279. Pflugfelder SC. Tear fluid influence on the ocular surface. Adv Exp Med Biol. 1998; 438:611-7. PMID: 9634944.
      Citations: 6     Fields:    Translation:HumansCells
    280. Jones DT, Monroy D, Ji Z, Pflugfelder SC. Alterations of ocular surface gene expression in Sjögren's syndrome. Adv Exp Med Biol. 1998; 438:533-6. PMID: 9634933.
      Citations: 30     Fields:    Translation:HumansCells
    281. Barton K, Nava A, Monroy DC, Pflugfelder SC. Cytokines and tear function in ocular surface disease. Adv Exp Med Biol. 1998; 438:461-9. PMID: 9634922.
      Citations: 8     Fields:    Translation:Humans
    282. Pflugfelder SC, Tseng SC, Sanabria O, Kell H, Garcia CG, Felix C, Feuer W, Reis BL. Evaluation of subjective assessments and objective diagnostic tests for diagnosing tear-film disorders known to cause ocular irritation. Cornea. 1998 Jan; 17(1):38-56. PMID: 9436879.
      Citations: 86     Fields:    Translation:HumansCTClinical Trials
    283. Gupta A, Heigle T, Pflugfelder SC. Nasolacrimal stimulation of aqueous tear production. Cornea. 1997 Nov; 16(6):645-8. PMID: 9395874.
      Citations: 9     Fields:    Translation:Humans
    284. Barton K, Monroy DC, Nava A, Pflugfelder SC. Inflammatory cytokines in the tears of patients with ocular rosacea. Ophthalmology. 1997 Nov; 104(11):1868-74. PMID: 9373119.
      Citations: 19     Fields:    Translation:Humans
    285. Nava A, Barton K, Monroy DC, Pflugfelder SC. The effects of age, gender, and fluid dynamics on the concentration of tear film epidermal growth factor. Cornea. 1997 Jul; 16(4):430-8. PMID: 9220241.
      Citations: 13     Fields:    Translation:Humans
    286. Jones DT, Monroy D, Pflugfelder SC. A novel method of tear collection: comparison of glass capillary micropipettes with porous polyester rods. Cornea. 1997 Jul; 16(4):450-8. PMID: 9220244.
      Citations: 8     Fields:    Translation:Humans
    287. Barton K, Miller D, Pflugfelder SC. Corneal chromoblastomycosis. Cornea. 1997 Mar; 16(2):235-9. PMID: 9071540.
      Citations: 7     Fields:    Translation:HumansAnimals
    288. Hoft RH, Pflugfelder SC, Forster RK, Ullman S, Polack FM, Schiff ER. Clinical evidence for hepatitis B transmission resulting from corneal transplantation. Cornea. 1997 Mar; 16(2):132-7. PMID: 9071524.
      Citations: 6     Fields:    Translation:HumansCells
    289. Pflugfelder SC, Tseng SC, Yoshino K, Monroy D, Felix C, Reis BL. Correlation of goblet cell density and mucosal epithelial membrane mucin expression with rose bengal staining in patients with ocular irritation. Ophthalmology. 1997 Feb; 104(2):223-35. PMID: 9052626.
      Citations: 60     Fields:    Translation:Humans
    290. Scott IU, Flynn HW, Feuer W, Pflugfelder SC, Alfonso EC, Forster RK, Miller D. Endophthalmitis associated with microbial keratitis. Ophthalmology. 1996 Nov; 103(11):1864-70. PMID: 8942882.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    291. Yoshino K, Monroy D, Pflugfelder SC. Cholinergic stimulation of lactoferrin and epidermal growth factor secretion by the human lacrimal gland. Cornea. 1996 Nov; 15(6):617-21. PMID: 8899275.
      Citations: 4     Fields:    Translation:Humans
    292. Gupta A, Monroy D, Ji Z, Yoshino K, Huang A, Pflugfelder SC. Transforming growth factor beta-1 and beta-2 in human tear fluid. Curr Eye Res. 1996 Jun; 15(6):605-14. PMID: 8670763.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    293. Yoshino K, Garg R, Monroy D, Ji Z, Pflugfelder SC. Production and secretion of transforming growth factor beta (TGF-beta) by the human lacrimal gland. Curr Eye Res. 1996 Jun; 15(6):615-24. PMID: 8670764.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    294. Pflugfelder SC. Differential diagnosis of dry eye conditions. Adv Dent Res. 1996 Apr; 10(1):9-12. PMID: 8934916.
      Citations: 5     Fields:    Translation:Humans
    295. Karp CL, Scott IU, Chang TS, Pflugfelder SC. Conjunctival intraepithelial neoplasia. A possible marker for human immunodeficiency virus infection? Arch Ophthalmol. 1996 Mar; 114(3):257-61. PMID: 8600883.
      Citations: 18     Fields:    Translation:Humans
    296. Heigle TJ, Pflugfelder SC. Aqueous tear production in patients with neurotrophic keratitis. Cornea. 1996 Mar; 15(2):135-8. PMID: 8925660.
      Citations: 18     Fields:    Translation:Humans
    297. Yoshino K, Tseng SC, Pflugfelder SC. Substrate modulation of morphology, growth, and tear protein production by cultured human lacrimal gland epithelial cells. Exp Cell Res. 1995 Sep; 220(1):138-51. PMID: 7664830.
      Citations: 11     Fields:    Translation:HumansCells
    298. Tu EY, Culbertson WW, Pflugfelder SC, Huang A, Chodosh JC. Therapy of nonnecrotizing anterior scleritis with subconjunctival corticosteroid injection. Ophthalmology. 1995 May; 102(5):718-24. PMID: 7777270.
      Citations: 7     Fields:    Translation:Humans
    299. Chodosh J, Miller D, Stroop WG, Pflugfelder SC. Adenovirus epithelial keratitis. Cornea. 1995 Mar; 14(2):167-74. PMID: 7743800.
      Citations: 14     Fields:    Translation:HumansCells
    300. Davis JL, Feuer W, Culbertson WW, Pflugfelder SC. Interpretation of intraocular and serum antibody levels in necrotizing retinitis. Retina. 1995; 15(3):233-40. PMID: 7569351.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    301. Jones DT, Monroy D, Ji Z, Atherton SS, Pflugfelder SC. Sjögren's syndrome: cytokine and Epstein-Barr viral gene expression within the conjunctival epithelium. Invest Ophthalmol Vis Sci. 1994 Aug; 35(9):3493-504. PMID: 8056525.
      Citations: 37     Fields:    Translation:HumansCells
    302. Pflugfelder SC, Crouse CA, Atherton SS. Epstein-Barr virus and the lacrimal gland pathology of Sjögren's syndrome. Adv Exp Med Biol. 1994; 350:641-6. PMID: 8030548.
      Citations:    Fields:    Translation:HumansCells
    303. Mao LK, Flynn HW, Miller D, Pflugfelder SC. Endophthalmitis caused by Staphylococcus aureus. Am J Ophthalmol. 1993 Nov 15; 116(5):584-9. PMID: 8238218.
      Citations: 7     Fields:    Translation:HumansCells
    304. Culbertson WW, Huang AJ, Mandelbaum SH, Pflugfelder SC, Boozalis GT, Miller D. Effective treatment of phlyctenular keratoconjunctivitis with oral tetracycline. Ophthalmology. 1993 Sep; 100(9):1358-66. PMID: 8371924.
      Citations: 5     Fields:    Translation:Humans
    305. Pflugfelder SC, Crouse CA, Monroy D, Yen M, Rowe M, Atherton SS. Epstein-Barr virus and the lacrimal gland pathology of Sjögren's syndrome. Am J Pathol. 1993 Jul; 143(1):49-64. PMID: 8391219.
      Citations: 17     Fields:    Translation:HumansCells
    306. Winward KE, Pflugfelder SC, Flynn HW, Roussel TJ, Davis JL. Postoperative Propionibacterium endophthalmitis. Treatment strategies and long-term results. Ophthalmology. 1993 Apr; 100(4):447-51. PMID: 8479698.
      Citations: 12     Fields:    Translation:HumansCells
    307. Rubsamen PE, McLeish WM, Pflugfelder S, Miller D. Capnocytophaga endophthalmitis. Ophthalmology. 1993 Apr; 100(4):456-9. PMID: 8479700.
      Citations:    Fields:    Translation:HumansCells
    308. Pflugfelder SC, Crouse CA, Atherton SS. Ophthalmic manifestations of Epstein-Barr virus infection. Int Ophthalmol Clin. 1993; 33(1):95-101. PMID: 8394294.
      Citations: 1     Fields:    Translation:HumansCells
    309. Pflugfelder SC, Flynn HW. Infectious endophthalmitis. Infect Dis Clin North Am. 1992 Dec; 6(4):859-73. PMID: 1460267.
      Citations: 4     Fields:    Translation:HumansAnimals
    310. Yen MT, Pflugfelder SC, Crouse CA, Atherton SS. Cytoskeletal antigen expression in ocular mucosa-associated lymphoid tissue. Invest Ophthalmol Vis Sci. 1992 Oct; 33(11):3235-41. PMID: 1399428.
      Citations: 3     Fields:    Translation:Humans
    311. Irvine WD, Flynn HW, Miller D, Pflugfelder SC. Endophthalmitis caused by gram-negative organisms. Arch Ophthalmol. 1992 Oct; 110(10):1450-4. PMID: 1417545.
      Citations: 28     Fields:    Translation:HumansCells
    312. Simon MW, Miller D, Pflugfelder SC, Murchison JF, Huang AJ, Atherton SS. Comparison of immunocytology to tissue culture for diagnosis of presumed herpesvirus dendritic epithelial keratitis. Ophthalmology. 1992 Sep; 99(9):1408-13. PMID: 1328982.
      Citations: 1     Fields:    Translation:HumansCells
    313. Pflugfelder SC, Roussel TJ, Denham D, Feuer W, Mandelbaum S, Parel JM. Photogrammetric analysis of corneal trephination. Arch Ophthalmol. 1992 Aug; 110(8):1160-6. PMID: 1497532.
      Citations: 4     Fields:    Translation:Humans
    314. Mao LK, Flynn HW, Miller D, Pflugfelder SC. Endophthalmitis caused by streptococcal species. Arch Ophthalmol. 1992 Jun; 110(6):798-801. PMID: 1596227.
      Citations: 14     Fields:    Translation:HumansCells
    315. Kervick GN, Pflugfelder SC, Haimovici R, Brown H, Tozman E, Yee R. Paracentral rheumatoid corneal ulceration. Clinical features and cyclosporine therapy. Ophthalmology. 1992 Jan; 99(1):80-8. PMID: 1741146.
      Citations: 15     Fields:    Translation:HumansCells
    316. Pflugfelder SC, Murchison JF. Corneal toxicity with an antibiotic/steroid-soaked collagen shield. Arch Ophthalmol. 1992 Jan; 110(1):20. PMID: 1731715.
      Citations:    Fields:    Translation:Humans
    317. Nanda M, Pflugfelder SC, Holland S. Fulminant pseudomonal keratitis and scleritis in human immunodeficiency virus-infected patients. Arch Ophthalmol. 1991 Apr; 109(4):503-5. PMID: 2012549.
      Citations: 5     Fields:    Translation:Humans
    318. Fox GM, Joondeph BC, Flynn HW, Pflugfelder SC, Roussel TJ. Delayed-onset pseudophakic endophthalmitis. Am J Ophthalmol. 1991 Feb 15; 111(2):163-73. PMID: 1992736.
      Citations: 22     Fields:    Translation:HumansCells
    319. Fox GM, Crouse CA, Chuang EL, Pflugfelder SC, Cleary TJ, Nelson SJ, Atherton SS. Detection of herpesvirus DNA in vitreous and aqueous specimens by the polymerase chain reaction. Arch Ophthalmol. 1991 Feb; 109(2):266-71. PMID: 1847043.
      Citations: 32     Fields:    Translation:HumansCells
    320. Kattan HM, Flynn HW, Pflugfelder SC, Robertson C, Forster RK. Nosocomial endophthalmitis survey. Current incidence of infection after intraocular surgery. Ophthalmology. 1991 Feb; 98(2):227-38. PMID: 2008282.
      Citations: 76     Fields:    Translation:Humans
    321. Flynn HW, Pulido JS, Pflugfelder SC, Davis JL, Culbertson WW, Roussel TJ, Miller D. Endophthalmitis therapy: changing antibiotic sensitivity patterns and current therapeutic recommendations. Arch Ophthalmol. 1991 Feb; 109(2):175-6. PMID: 1993022.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    322. Feist RM, Lim JI, Joondeph BC, Pflugfelder SC, Mieler WF, Ticho BH, Resnick K. Penetrating ocular injury from contaminated eating utensils. Arch Ophthalmol. 1991 Jan; 109(1):63-6. PMID: 1987951.
      Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
    323. Pepose JS, Akata RF, Pflugfelder SC, Voigt W. Mononuclear cell phenotypes and immunoglobulin gene rearrangements in lacrimal gland biopsies from patients with Sjögren's syndrome. Ophthalmology. 1990 Dec; 97(12):1599-605. PMID: 1965021.
      Citations: 16     Fields:    Translation:HumansCells
    324. Pflugfelder SC, Huang A, Crouse C. Epstein-Barr virus keratitis after a chemical facial peel. Am J Ophthalmol. 1990 Nov 15; 110(5):571-3. PMID: 2173408.
      Citations: 3     Fields:    Translation:HumansCells
    325. Kattan HM, Pflugfelder SC. Nocardia scleritis. Am J Ophthalmol. 1990 Oct 15; 110(4):446-7. PMID: 2220994.
      Citations: 7     Fields:    Translation:Humans
    326. Duffner LR, Pflugfelder SC, Mandelbaum S, Childress LL. Potential bacterial contamination in fluorescein-anesthetic solutions. Am J Ophthalmol. 1990 Aug 15; 110(2):199-202. PMID: 2116089.
      Citations:    Fields:    Translation:CellsPHPublic Health
    327. Pflugfelder SC, Huang AJ, Feuer W, Chuchovski PT, Pereira IC, Tseng SC. Conjunctival cytologic features of primary Sjögren's syndrome. Ophthalmology. 1990 Aug; 97(8):985-91. PMID: 1698273.
      Citations: 38     Fields:    Translation:HumansCells
    328. Pflugfelder SC, Crouse C, Pereira I, Atherton S. Amplification of Epstein-Barr virus genomic sequences in blood cells, lacrimal glands, and tears from primary Sjögren's syndrome patients. Ophthalmology. 1990 Aug; 97(8):976-84. PMID: 2169602.
      Citations: 10     Fields:    Translation:HumansCells
    329. Rosenwasser GO, Holland S, Pflugfelder SC, Lugo M, Heidemann DG, Culbertson WW, Kattan H. Topical anesthetic abuse. Ophthalmology. 1990 Aug; 97(8):967-72. PMID: 2402423.
      Citations: 12     Fields:    Translation:Humans
    330. Crouse CA, Pflugfelder SC, Pereira I, Cleary T, Rabinowitz S, Atherton SS. Detection of herpes viral genomes in normal and diseased corneal epithelium. Curr Eye Res. 1990 Jun; 9(6):569-81. PMID: 2167192.
      Citations: 15     Fields:    Translation:HumansCells
    331. Brod RD, Flynn HW, Clarkson JG, Pflugfelder SC, Culbertson WW, Miller D. Endogenous Candida endophthalmitis. Management without intravenous amphotericin B. Ophthalmology. 1990 May; 97(5):666-72; disc: 672-4. PMID: 2188195.
      Citations: 10     Fields:    Translation:HumansAnimals
    332. Pflugfelder SC, Tseng SC, Pepose JS, Fletcher MA, Klimas N, Feuer W. Epstein-Barr virus infection and immunologic dysfunction in patients with aqueous tear deficiency. Ophthalmology. 1990 Mar; 97(3):313-23. PMID: 2159609.
      Citations: 9     Fields:    Translation:HumansCells
    333. McLeish W, Pflugfelder SC, Crouse C, Rabinowitz S, Miller D, Hill EL, Atherton S. Interferon treatment of herpetic keratitis in a patient with acquired immunodeficiency syndrome. Am J Ophthalmol. 1990 Jan 15; 109(1):93-5. PMID: 2153343.
      Citations: 2     Fields:    Translation:HumansCells
    334. Rosenfeld SI, Mandelbaum S, Corrent GF, Pflugfelder SC, Culbertson WW. Granular epithelial keratopathy as an unusual manifestation of Pseudomonas keratitis associated with extended-wear soft contact lenses. Am J Ophthalmol. 1990 Jan 15; 109(1):17-22. PMID: 2105056.
      Citations: 1     Fields:    Translation:HumansCells
    335. Levine J, Pflugfelder SC, Yen M, Crouse CA, Atherton SS. Detection of the complement (CD21)/Epstein-Barr virus receptor in human lacrimal gland and ocular surface epithelia. Reg Immunol. 1990-1991; 3(4):164-70. PMID: 1966579.
      Citations: 4     Fields:    Translation:HumansCells
    336. Nanda M, Pflugfelder SC, Holland S. Mycobacterium tuberculosis scleritis. Am J Ophthalmol. 1989 Dec 15; 108(6):736-7. PMID: 2512813.
      Citations: 4     Fields:    Translation:HumansCells
    337. Denham D, Mandelbaum S, Parel JM, Holland S, Pflugfelder S, Parel JM. Shadow photogrammetric apparatus for the quantitative evaluation of corneal buttons. Ophthalmic Surg. 1989 Nov; 20(11):794-9. PMID: 2616127.
      Citations: 4     Fields:    Translation:Humans
    338. Rabinowitz SM, Pflugfelder SC, Goldberg M. Disposable extended-wear contact lens-related keratitis. Case report. Arch Ophthalmol. 1989 Aug; 107(8):1121. PMID: 2502975.
      Citations:    Fields:    Translation:HumansCells
    339. Zambrano W, Flynn HW, Pflugfelder SC, Roussel TJ, Culbertson WW, Holland S, Miller D. Management options for Propionibacterium acnes endophthalmitis. Ophthalmology. 1989 Jul; 96(7):1100-5. PMID: 2788852.
      Citations: 14     Fields:    Translation:HumansCells
    340. Thompson KP, Barraquer E, Parel JM, Loertscher H, Pflugfelder S, Roussel T, Holland S, Hanna K. Potential use of lasers for penetrating keratoplasty. J Cataract Refract Surg. 1989 Jul; 15(4):397-403. PMID: 2674411.
      Citations: 1     Fields:    Translation:Humans
    341. Kattan H, Pflugfelder SC. Complications of intraocular antimicrobial agents. Int Ophthalmol Clin. 1989; 29(3):188-94. PMID: 2666333.
      Citations:    Fields:    Translation:HumansAnimals
    342. Duerksen KM, Albert DW, Saulson RM, Pflugfelder SC. Soda pop top ophthalmopathy. Am J Ophthalmol. 1988 Dec 15; 106(6):761-2. PMID: 3195669.
      Citations: 2     Fields:    Translation:Humans
    343. Davis JL, Koidou-Tsiligianni A, Pflugfelder SC, Miller D, Flynn HW, Forster RK. Coagulase-negative staphylococcal endophthalmitis. Increase in antimicrobial resistance. Ophthalmology. 1988 Oct; 95(10):1404-10. PMID: 3265776.
      Citations: 8     Fields:    Translation:HumansCells
    344. Pflugfelder SC, Suelflow J, Pflugfelder ME, Parke DW. Serum and vitreous herpes simplex antibodies in noninfected eyes. Ann Ophthalmol. 1988 Sep; 20(9):355-7. PMID: 2847623.
      Citations:    Fields:    Translation:HumansCells
    345. Heidemann DG, Pflugfelder SC, Kronish J, Alfonso EC, Dunn SP, Ullman S. Necrotizing keratitis caused by Capnocytophaga ochracea. Am J Ophthalmol. 1988 Jun 15; 105(6):655-60. PMID: 3377043.
      Citations: 3     Fields:    Translation:HumansCells
    346. Buus DR, Pflugfelder SC, Schachter J, Miller D, Forster RK. Lymphogranuloma venereum conjunctivitis with a marginal corneal perforation. Ophthalmology. 1988 Jun; 95(6):799-802. PMID: 3062531.
      Citations: 1     Fields:    Translation:HumansCells
    347. Pflugfelder SC, Parel JM, Denham D, Mandelbaum S. A suction trephine block for marking donor corneal buttons. Arch Ophthalmol. 1988 Feb; 106(2):276-81. PMID: 3277610.
      Citations: 1     Fields:    Translation:Humans
    348. Pflugfelder SC, Flynn HW, Zwickey TA, Forster RK, Tsiligianni A, Culbertson WW, Mandelbaum S. Exogenous fungal endophthalmitis. Ophthalmology. 1988 Jan; 95(1):19-30. PMID: 3257818.
      Citations: 35     Fields:    Translation:HumansCells
    349. Pflugfelder SC, Saulson R, Ullman S. Peripheral corneal ulceration in a patient with AIDS-related complex. Am J Ophthalmol. 1987 Nov 15; 104(5):542-3. PMID: 3674189.
      Citations:    Fields:    Translation:Humans
    350. Pflugfelder SC, Hernández E, Fliesler SJ, Alvarez J, Pflugfelder ME, Forster RK. Intravitreal vancomycin. Retinal toxicity, clearance, and interaction with gentamicin. Arch Ophthalmol. 1987 Jun; 105(6):831-7. PMID: 3495255.
      Citations: 27     Fields:    Translation:Animals
    351. Ullman S, Pflugfelder SC. A supplemental labeling system for topical medications. Am J Ophthalmol. 1987 Mar 15; 103(3 Pt 1):335. PMID: 3826245.
      Citations: 1     Fields:    Translation:Humans
    352. Pflugfelder SC, Roussel TJ, Culbertson WW. Primary Sjögren's syndrome after infectious mononucleosis. JAMA. 1987 Feb 27; 257(8):1049-50. PMID: 3806887.
      Citations: 1     Fields:    Translation:Humans
    353. Ullman S, Pflugfelder SC, Hughes R, Forster RK. Bacillus cereus panophthalmitis manifesting as an orbital cellulitis. Am J Ophthalmol. 1987 Jan 15; 103(1):105-6. PMID: 3099579.
      Citations: 2     Fields:    Translation:HumansCells
    354. Pflugfelder SC, Wilhelmus KR, Osato MS, Matoba AY, Font RL. The autoimmune nature of aqueous tear deficiency. Ophthalmology. 1986 Dec; 93(12):1513-7. PMID: 3808613.
      Citations: 14     Fields:    Translation:Humans
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