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SILKE PAUST

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Human Immunobiology
Address1102 Bates St.
Suite 330
Houston TX 77030
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Virology & Microbiology
    DivisionMolecular Virology & Microbiology


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    Collapse Biography 
    Collapse awards and honors
    2007 - 2010Irvington post-doctoral fellowship of the Cancer Research Institute, Harvard Medical School, Boston, MA
    2010 - 2012Ragon Institute of Harvard, MIT and MGH post-doctoral fellowship, Harvard Medical School, Boston, MA
    2012 - 2013T32 NIH Training Grant, Children's Hospital, Boston, MA
    2004The Hauser Award for outstanding achievement in scientific research and teaching., Harvard Medical School, Boston, MA
    2008Keystone Symposia Fellowship: NK and NKT cell biology, Keystone, CO., Keystone Symposia
    2010HMS Travel Fellowship; Harvard Medical School, Boston, MA., Harvard Medical School, Boston, MA
    2012Travel award: NK2012 meeting of the Society of Natural Immunity, Asilomar, CA., Society of Natural Immunity
    2014Woman and Diversity Award, Society for Leukocyte Biology., Society for Leukocyte Biology

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. You R, DeMayo FJ, Liu J, Cho SN, Burt B, Creighton CJ, Casal RF, Lazarus DR, Lu W, Tung HY, Yuan X, Hill-McALester A, Kim M, Perusich S, Cornwell L, Rosen D, Song LZ, Paust S, Diehl G, Corry D, Kheradmand F. IL17A Regulates Tumor Latency and Metastasis in Lung Adeno and Squamous SQ.2b and AD.1 Cancer. Cancer Immunol Res. 2018 Apr 13. PMID: 29653981.
      View in: PubMed
    2. Liang D, Tian L, You R, Halpert MM, Konduri V, Baig YC, Paust S, Kim D, Kim S, Jia F, Huang S, Zhang X, Kheradmand F, Corry DB, Gilbert BE, Levitt JM, Decker WK. AIMp1 Potentiates TH1 Polarization and Is Critical for Effective Antitumor and Antiviral Immunity. Front Immunol. 2017; 8:1801. PMID: 29379495.
      View in: PubMed
    3. Moreno-Smith M, Lakoma A, Chen Z, Tao L, Scorsone KA, Schild L, Aviles-Padilla K, Nikzad R, Zhang Y, Chakraborty R, Molenaar JJ, Vasudevan S, Sheehan V, Kim ES, Paust S, Shohet JM, Barbieri E. p53 non-genotoxic activation and mTORC1 inhibition lead to effective combination for neuroblastoma therapy. Clin Cancer Res. 2017 Aug 18. PMID: 28821555.
      View in: PubMed
    4. Paust S, Blish CA, Reeves RK. Redefining Memory: Building the Case for Adaptive NK cells. J Virol. 2017 Aug 09. PMID: 28794018.
      View in: PubMed
    5. Decker WK, da Silva RF, Sanabria MH, Angelo LS, Guimarães F, Burt BM, Kheradmand F, Paust S. Cancer Immunotherapy: Historical Perspective of a Clinical Revolution and Emerging Preclinical Animal Models. Front Immunol. 2017; 8:829. PMID: 28824608.
      View in: PubMed
    6. da Silva RF, Yoshida A, Cardozo DM, Jales RM, Paust S, Derchain S, Guimarães F. Natural Killer Cells Response to IL-2 Stimulation Is Distinct between Ascites with the Presence or Absence of Malignant Cells in Ovarian Cancer Patients. Int J Mol Sci. 2017 May 17; 18(5). PMID: 28513532.
      View in: PubMed
    7. Tao W, Hurst B, Shakya AK, Uddin MJ, Ingrole RS, Hernandez-Sanabria M, Arya R, Bimler L, Paust S, Tarbet EB, Gill HS. Consensus M2e peptide conjugated to gold nanoparticles confers protection against H1N1, H3N2 and H5N1 influenza A viruses. Antiviral Res. 2017 Feb 01. PMID: 28161578.
      View in: PubMed
    8. Mace EM, Bigley V, Gunesch JT, Chinn IK, Angelo LS, Care MA, Maisuria S, Keller MD, Togi S, Watkin LB, LaRosa DF, Jhangiani SN, Muzny DM, Stray-Pedersen A, Coban Akdemir Z, Smith JB, Hernández-Sanabria M, Le DT, Hogg GD, Cao TN, Freud AG, Szymanski EP, Savic S, Collin M, Cant AJ, Gibbs RA, Holland SM, Caligiuri MA, Ozato K, Paust S, Doody GM, Lupski JR, Orange JS. Biallelic mutations in IRF8 impair human NK cell maturation and function. J Clin Invest. 2017 Jan 03; 127(1):306-320. PMID: 27893462.
      View in: PubMed
    9. Konduri V, Li D, Halpert MM, Liang D, Liang Z, Chen Y, Fisher WE, Paust S, Levitt JM, Yao QC, Decker WK. Chemo-immunotherapy mediates durable cure of orthotopic Kras(G12D)/p53(-/-) pancreatic ductal adenocarcinoma. Oncoimmunology. 2016; 5(9):e1213933. PMID: 27757308.
      View in: PubMed
    10. Sekine T, Marin D, Cao K, Li L, Mehta P, Shaim H, Sobieski C, Jones R, Oran B, Hosing C, Rondon G, Alsuliman A, Paust S, Andersson B, Popat U, Kebriaei P, Muftuoglu M, Basar R, Kondo K, Nieto Y, Shah N, Olson A, Alousi A, Liu E, Sarvaria A, Parmar S, Armstrong-James D, Imahashi N, Molldrem J, Champlin R, Shpall EJ, Rezvani K. Specific combinations of donor and recipient KIR-HLA genotypes predict for large differences in outcome after cord blood transplantation. Blood. 2016 May 31. PMID: 27247137.
      View in: PubMed
    11. Bissig KD, Paust S, Barzi M. Liver is liver and blood is blood, and finally the twain have met. J Hepatol. 2016 May 21. PMID: 27221221.
      View in: PubMed
    12. Halpert MM, Konduri V, Liang D, Chen Y, Wing JB, Paust S, Levitt JM, Decker WK. Dendritic Cell-Secreted Cytotoxic T-Lymphocyte-Associated Protein-4 Regulates the T-cell Response by Downmodulating Bystander Surface B7. Stem Cells Dev. 2016 May 15; 25(10):774-87. PMID: 26979751; PMCID: PMC4870609 [Available on 05/15/17].
    13. Paust S, Bettini M. Daring to learn from humanized mice. Blood. 2015 Jun 18; 125(25):3829-31. PMID: 26089378.
      View in: PubMed
    14. Riol-Blanco L, Ordovas-Montanes J, Perro M, Naval E, Thiriot A, Alvarez D, Paust S, Wood JN, von Andrian UH. Nociceptive sensory neurons drive interleukin-23-mediated psoriasiform skin inflammation. Nature. 2014 Jun 5; 510(7503):157-61. PMID: 24759321; PMCID: PMC4127885.
    15. Majewska-Szczepanik M, Paust S, von Andrian UH, Askenase PW, Szczepanik M. Natural killer cell-mediated contact sensitivity develops rapidly and depends on interferon-?, interferon-? and interleukin-12. Immunology. 2013 Sep; 140(1):98-110. PMID: 23659714; PMCID: PMC3809710.
    16. Paust S, von Andrian UH. Natural killer cell memory. Nat Immunol. 2011 Jun; 12(6):500-8. PMID: 21739673.
      View in: PubMed
    17. Paust S, Gill HS, Wang BZ, Flynn MP, Moseman EA, Senman B, Szczepanik M, Telenti A, Askenase PW, Compans RW, von Andrian UH. Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. Nat Immunol. 2010 Dec; 11(12):1127-35. PMID: 20972432; PMCID: PMC2982944.
    18. Paust S, Senman B, von Andrian UH. Adaptive immune responses mediated by natural killer cells. Immunol Rev. 2010 May; 235(1):286-96. PMID: 20536570; PMCID: PMC2911633.
    19. Paust S, Cantor H. Regulatory T cells and autoimmune disease. Immunol Rev. 2005 Apr; 204:195-207. PMID: 15790360.
      View in: PubMed
    20. McCarty N, Paust S, Ikizawa K, Dan I, Li X, Cantor H. Signaling by the kinase MINK is essential in the negative selection of autoreactive thymocytes. Nat Immunol. 2005 Jan; 6(1):65-72. PMID: 15608642.
      View in: PubMed
    21. Paust S, Lu L, McCarty N, Cantor H. Engagement of B7 on effector T cells by regulatory T cells prevents autoimmune disease. Proc Natl Acad Sci U S A. 2004 Jul 13; 101(28):10398-403. PMID: 15235129; PMCID: PMC478583.
    22. Plas DR, Williams CB, Kersh GJ, White LS, White JM, Paust S, Ulyanova T, Allen PM, Thomas ML. Cutting edge: the tyrosine phosphatase SHP-1 regulates thymocyte positive selection. J Immunol. 1999 May 15; 162(10):5680-4. PMID: 10229799.
      View in: PubMed
    23. Blasioli J, Paust S, Thomas ML. Definition of the sites of interaction between the protein tyrosine phosphatase SHP-1 and CD22. J Biol Chem. 1999 Jan 22; 274(4):2303-7. PMID: 9890995.
      View in: PubMed
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