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ROLANDO RUMBAUT

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
DivisionMedicine-Pulmonary
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pediatrics
    DivisionPediatrics-Leukocyte Biology


    Collapse Research 
    Collapse research activities and funding
    K08HL003738     (RUMBAUT, ROLANDO E)Sep 1, 1997 - Aug 31, 2000
    NIH/NHLBI
    REGULATION OF MICROVASCULAR PERMEABILITY BY NITRIC OXIDE
    Role: Principal Investigator

    R01HL064721     (RUMBAUT, ROLANDO E)Jul 1, 2001 - May 31, 2005
    NIH/NHLBI
    Regulation of microvascular permeability by nitric oxide
    Role: Principal Investigator

    R01HL079368     (RUMBAUT, ROLANDO E)Apr 1, 2006 - Mar 31, 2012
    NIH/NHLBI
    MECHANISMS OF MICROVASCULAR THROMBOSIS IN ENDOTOXEMIA
    Role: Principal Investigator

    R01EY018239     (RUMBAUT, ROLANDO E)Apr 1, 2007 - Sep 29, 2016
    NIH/NEI
    Ocular Surface Injury: Inflammatory Cascade and Healing of Corneal Wounds
    Role: Principal Investigator

    I01BX000550     (RUMBAUT, ROLANDO E)Oct 1, 2009 - Sep 30, 2014
    VA
    The complement system links platelet activation to inflammation
    Role: Principal Investigator

    R01HL116524     (RUMBAUT, ROLANDO E)Feb 1, 2013 - Jan 31, 2018
    NIH/NHLBI
    Platelets and Their Microparticles in the Inflamed Microcirculation
    Role: Principal Investigator

    I01BX002551     (RUMBAUT, ROLANDO E)Apr 1, 2016 - Mar 31, 2020
    VA
    Platelets and microvascular thrombosis in inflammation
    Role: Principal Investigator

    IS1BX003082     (RUMBAUT, ROLANDO E)May 1, 2016 - Sep 30, 2016
    VA
    LAMb Request for Laboratory Animal Major Vivarium Equipment
    Role: Principal Investigator

    IS1BX003967     (RUMBAUT, ROLANDO E)Jan 1, 2017 - Sep 30, 2017
    VA
    ShEEP Request for Super Resolution Laser Scanning Confocal Microscopy System
    Role: Principal Investigator

    T32HL139425     (RUMBAUT, ROLANDO E)Aug 1, 2018 - Jul 31, 2023
    NIH/NHLBI
    Collaborative Research Training in Thrombosis and Inflammation
    Role: Principal Investigator

    IS1BX004798     (RUMBAUT, ROLANDO E)Jan 1, 2019 - Sep 30, 2019
    VA
    ShEEP request for high-resolution flow cytometry system
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hargrave A, Courson JA, Pham V, Landry P, Magadi S, Shankar P, Hanlon S, Das A, Rumbaut RE, Smith CW, Burns AR. Corneal dysfunction precedes the onset of hyperglycemia in a mouse model of diet-induced obesity. PLoS One. 2020; 15(9):e0238750. PMID: 32886728.
      View in: PubMed
    2. Bray MA, Sartain SE, Gollamudi J, Rumbaut RE. Microvascular thrombosis: experimental and clinical implications. Transl Res. 2020 May 23. PMID: 32454092.
      View in: PubMed
    3. Valladolid C, Martinez-Vargas M, Sekhar N, Lam F, Brown C, Palzkill T, Tischer A, Auton M, Vijayan KV, Rumbaut RE, Nguyen TC, Cruz MA. Modulating the rate of fibrin formation and clot structure attenuates microvascular thrombosis in systemic inflammation. Blood Adv. 2020 Apr 14; 4(7):1340-1349. PMID: 32259201.
      View in: PubMed
    4. Courson JA, Smith I, Do T, Landry PT, Hargrave A, Behzad AR, Hanlon SD, Rumbaut RE, Smith CW, Burns AR. Serial block-face scanning electron microscopy reveals neuronal-epithelial cell fusion in the mouse cornea. PLoS One. 2019; 14(11):e0224434. PMID: 31721785.
      View in: PubMed
    5. Osae EA, Steven P, Redfern R, Hanlon S, Smith CW, Rumbaut RE, Burns AR. Dyslipidemia and Meibomian Gland Dysfunction: Utility of Lipidomics and Experimental Prospects with a Diet-Induced Obesity Mouse Model. Int J Mol Sci. 2019 Jul 17; 20(14). PMID: 31319467.
      View in: PubMed
    6. Cardenas EI, Gonzalez R, Breaux K, Da Q, Gutierrez BA, Ramos MA, Cardenas RA, Burns AR, Rumbaut RE, Adachi R. Munc18-2, but not Munc18-1 or Munc18-3, regulates platelet exocytosis, hemostasis, and thrombosis. J Biol Chem. 2019 03 29; 294(13):4784-4792. PMID: 30696774.
      View in: PubMed
    7. Da Q, Derry PJ, Lam FW, Rumbaut RE. Fluorescent labeling of endogenous platelets for intravital microscopy: Effects on platelet function. Microcirculation. 2018 08; 25(6):e12457. PMID: 29701894.
      View in: PubMed
    8. Cardenas EI, Breaux K, Da Q, Flores JR, Ramos MA, Tuvim MJ, Burns AR, Rumbaut RE, Adachi R. Platelet Munc13-4 regulates hemostasis, thrombosis and airway inflammation. Haematologica. 2018 07; 103(7):1235-1244. PMID: 29674495.
      View in: PubMed
    9. Royse KE, Chen L, Berger DH, Ittmann MM, El-Serag HB, Balentine CJ, Graham DY, Richardson PA, Rumbaut RE, Shen X, White DL, Jiao L. Expression of pattern recognition receptor genes and mortality in patients with colorectal adenocarcinoma. Int J Mol Epidemiol Genet. 2017; 8(2):8-18. PMID: 28533893.
      View in: PubMed
    10. Dasgupta SK, Le A, Da Q, Cruz M, Rumbaut RE, Thiagarajan P. Wdr1-Dependent Actin Reorganization in Platelet Activation. PLoS One. 2016; 11(9):e0162897. PMID: 27627652.
      View in: PubMed
    11. Lam FW, Cruz MA, Parikh K, Rumbaut RE. Histones stimulate von Willebrand factor release in vitro and in vivo. Haematologica. 2016 07; 101(7):e277-9. PMID: 27013650.
      View in: PubMed
    12. Lam FW, Rumbaut RE. Platelets mediate acetaminophen hepatotoxicity. Blood. 2015 Oct 08; 126(15):1738-9. PMID: 26450954.
      View in: PubMed
    13. Lam FW, Vijayan KV, Rumbaut RE. Platelets and Their Interactions with Other Immune Cells. Compr Physiol. 2015 Jul 01; 5(3):1265-80. PMID: 26140718.
      View in: PubMed
    14. Casal RF, Lazarus DR, Kuhl K, Nogueras-González G, Perusich S, Green LK, Ost DE, Sarkiss M, Jimenez CA, Eapen GA, Morice RC, Cornwell L, Austria S, Sharafkanneh A, Rumbaut RE, Grosu H, Kheradmand F. Randomized trial of endobronchial ultrasound-guided transbronchial needle aspiration under general anesthesia versus moderate sedation. Am J Respir Crit Care Med. 2015 Apr 01; 191(7):796-803. PMID: 25574801.
      View in: PubMed
    15. Lam FW, Phillips J, Landry P, Magadi S, Smith CW, Rumbaut RE, Burns AR. Platelet recruitment promotes keratocyte repopulation following corneal epithelial abrasion in the mouse. PLoS One. 2015; 10(3):e0118950. PMID: 25775402.
      View in: PubMed
    16. Khatlani T, Pradhan S, Da Q, Gushiken FC, Bergeron AL, Langlois KW, Molkentin JD, Rumbaut RE, Vijayan KV. The ß isoform of the catalytic subunit of protein phosphatase 2B restrains platelet function by suppressing outside-in aII b ß3 integrin signaling. J Thromb Haemost. 2014 Dec; 12(12):2089-101. PMID: 25330904.
      View in: PubMed
    17. Dasgupta SK, Le A, Haudek SB, Entman ML, Rumbaut RE, Thiagarajan P. Rho associated coiled-coil kinase-1 regulates collagen-induced phosphatidylserine exposure in platelets. PLoS One. 2013; 8(12):e84649. PMID: 24358370.
      View in: PubMed
    18. Lam FW, Cruz MA, Leung HC, Parikh KS, Smith CW, Rumbaut RE. Histone induced platelet aggregation is inhibited by normal albumin. Thromb Res. 2013 Jul; 132(1):69-76. PMID: 23673386.
      View in: PubMed
    19. Zhou Z, Gushiken FC, Bolgiano D, Salsbery BJ, Aghakasiri N, Jing N, Wu X, Vijayan KV, Rumbaut RE, Adachi R, Lopez JA, Dong JF. Signal transducer and activator of transcription 3 (STAT3) regulates collagen-induced platelet aggregation independently of its transcription factor activity. Circulation. 2013 Jan 29; 127(4):476-485. PMID: 23266857.
      View in: PubMed
    20. Stark RJ, Aghakasiri N, Rumbaut RE. Platelet-derived Toll-like receptor 4 (Tlr-4) is sufficient to promote microvascular thrombosis in endotoxemia. PLoS One. 2012; 7(7):e41254. PMID: 22911769.
      View in: PubMed
    21. Dasgupta SK, Le A, Chavakis T, Rumbaut RE, Thiagarajan P. Developmental endothelial locus-1 (Del-1) mediates clearance of platelet microparticles by the endothelium. Circulation. 2012 Apr 03; 125(13):1664-72. PMID: 22388320.
      View in: PubMed
    22. Li Z, Burns AR, Han L, Rumbaut RE, Smith CW. IL-17 and VEGF are necessary for efficient corneal nerve regeneration. Am J Pathol. 2011 Mar; 178(3):1106-16. PMID: 21356362.
      View in: PubMed
    23. Lam FW, Burns AR, Smith CW, Rumbaut RE. Platelets enhance neutrophil transendothelial migration via P-selectin glycoprotein ligand-1. Am J Physiol Heart Circ Physiol. 2011 Feb; 300(2):H468-75. PMID: 21169400.
      View in: PubMed
    24. Patel KN, Soubra SH, Lam FW, Rodriguez MA, Rumbaut RE. Polymicrobial sepsis and endotoxemia promote microvascular thrombosis via distinct mechanisms. J Thromb Haemost. 2010 Jun; 8(6):1403-9. PMID: 20345726.
      View in: PubMed
    25. Godin B, Driessen WH, Proneth B, Lee SY, Srinivasan S, Rumbaut R, Arap W, Pasqualini R, Ferrari M, Decuzzi P. An integrated approach for the rational design of nanovectors for biomedical imaging and therapy. Adv Genet. 2010; 69:31-64. PMID: 20807601.
      View in: PubMed
    26. Rumbaut RE, Thiagarajan P. Integrated Systems Physiology: from Molecule to Function to Disease. Platelet-Vessel Wall Interactions in Hemostasis and Thrombosis. 2010; 1-67.
    27. Gushiken FC, Hyojeong H, Pradhan S, Langlois KW, Alrehani N, Cruz MA, Rumbaut RE, Vijayan KV. The catalytic subunit of protein phosphatase 1 gamma regulates thrombin-induced murine platelet alpha(IIb)beta(3) function. PLoS One. 2009 Dec 15; 4(12):e8304. PMID: 20016849.
      View in: PubMed
    28. Byeseda SE, Burns AR, Dieffenbaugher S, Rumbaut RE, Smith CW, Li Z. ICAM-1 is necessary for epithelial recruitment of gammadelta T cells and efficient corneal wound healing. Am J Pathol. 2009 Aug; 175(2):571-9. PMID: 19608878.
      View in: PubMed
    29. Gushiken FC, Han H, Li J, Rumbaut RE, Afshar-Kharghan V. Abnormal platelet function in C3-deficient mice. J Thromb Haemost. 2009 May; 7(5):865-70. PMID: 19291167.
      View in: PubMed
    30. Dasgupta SK, Abdel-Monem H, Niravath P, Le A, Bellera RV, Langlois K, Nagata S, Rumbaut RE, Thiagarajan P. Lactadherin and clearance of platelet-derived microvesicles. Blood. 2009 Feb 05; 113(6):1332-9. PMID: 19023116.
      View in: PubMed
    31. Patel KN, Soubra SH, Bellera RV, Dong JF, McMullen CA, Burns AR, Rumbaut RE. Differential role of von Willebrand factor and P-selectin on microvascular thrombosis in endotoxemia. Arterioscler Thromb Vasc Biol. 2008 Dec; 28(12):2225-2230. PMID: 18802014.
      View in: PubMed
    32. Guchhait P, Shrimpton CN, Honke K, Rumbaut RE, Lopez JA, Thiagarajan P. Effect of an anti-sulfatide single-chain antibody probe on platelet function. Thromb Haemost. 2008 Mar; 99(3):552-7. PMID: 18327404.
      View in: PubMed
    33. Rumbaut RE, Mirkovic D. Magnetic therapy for edema in inflammation: a physiological assessment. Am J Physiol Heart Circ Physiol. 2008 Jan; 294(1):H19-20. PMID: 18032520.
      View in: PubMed
    34. Burns AR, Zheng Z, Soubra SH, Chen J, Rumbaut RE. Transendothelial flow inhibits neutrophil transmigration through a nitric oxide-dependent mechanism: potential role for cleft shear stress. Am J Physiol Heart Circ Physiol. 2007 Nov; 293(5):H2904-10. PMID: 17720767.
      View in: PubMed
    35. Li Z, Burns AR, Rumbaut RE, Smith CW. gamma delta T cells are necessary for platelet and neutrophil accumulation in limbal vessels and efficient epithelial repair after corneal abrasion. Am J Pathol. 2007 Sep; 171(3):838-45. PMID: 17675580.
      View in: PubMed
    36. Sorg H, Hoffmann JN, Rumbaut RE, Menger MD, Lindenblatt N, Vollmar B. Efficacy of antithrombin in the prevention of microvascular thrombosis during endotoxemia: an intravital microscopic study. Thromb Res. 2007; 121(2):241-8. PMID: 17512574.
      View in: PubMed
    37. Li Z, Rumbaut RE, Burns AR, Smith CW. Platelet response to corneal abrasion is necessary for acute inflammation and efficient re-epithelialization. Invest Ophthalmol Vis Sci. 2006 Nov; 47(11):4794-802. PMID: 17065490.
      View in: PubMed
    38. Andrade FH, McMullen CA, Rumbaut RE. Mitochondria are fast Ca2+ sinks in rat extraocular muscles: a novel regulatory influence on contractile function and metabolism. Invest Ophthalmol Vis Sci. 2005 Dec; 46(12):4541-7. PMID: 16303946.
      View in: PubMed
    39. Rumbaut RE, Bellera RV, Randhawa JK, Shrimpton CN, Dasgupta SK, Dong JF, Burns AR. Endotoxin enhances microvascular thrombosis in mouse cremaster venules via a TLR4-dependent, neutrophil-independent mechanism. Am J Physiol Heart Circ Physiol. 2006 Apr; 290(4):H1671-9. PMID: 16284241.
      View in: PubMed
    40. Jiang X, Yang F, Tan H, Liao D, Bryan RM, Randhawa JK, Rumbaut RE, Durante W, Schafer AI, Yang X, Wang H. Hyperhomocystinemia impairs endothelial function and eNOS activity via PKC activation. Arterioscler Thromb Vasc Biol. 2005 Dec; 25(12):2515-21. PMID: 16210565.
      View in: PubMed
    41. Dhillon SS, Mahadevan K, Bandi V, Zheng Z, Smith CW, Rumbaut RE. Neutrophils, nitric oxide, and microvascular permeability in severe sepsis. Chest. 2005 Sep; 128(3):1706-12. PMID: 16162778.
      View in: PubMed
    42. Rumbaut RE. Platelet-microvessel interactions. Microcirculation. 2005 Apr-May; 12(3):233-4. PMID: 15814432.
      View in: PubMed
    43. Rumbaut RE, Slaff DW, Burns AR. Microvascular thrombosis models in venules and arterioles in vivo. Microcirculation. 2005 Apr-May; 12(3):259-74. PMID: 15814435.
      View in: PubMed
    44. Rumbaut RE, Randhawa JK, Smith CW, Burns AR. Mouse cremaster venules are predisposed to light/dye-induced thrombosis independent of wall shear rate, CD18, ICAM-1, or P-selectin. Microcirculation. 2004 Apr-May; 11(3):239-47. PMID: 15280078.
      View in: PubMed
    45. Bingaman S, Huxley VH, Rumbaut RE. Fluorescent dyes modify properties of proteins used in microvascular research. Microcirculation. 2003 Apr; 10(2):221-31. PMID: 12700589.
      View in: PubMed
    46. Harris NR, Whitt SP, Zilberberg J, Alexander JS, Rumbaut RE. Extravascular transport of fluorescently labeled albumins in the rat mesentery. Microcirculation. 2002 Jul; 9(3):177-87. PMID: 12080415.
      View in: PubMed
    47. Rumbaut RE, Huxley VH. Similar permeability responses to nitric oxide synthase inhibitors of venules from three animal species. Microvasc Res. 2002 Jul; 64(1):21-31. PMID: 12074627.
      View in: PubMed
    48. Harris NR, Rumbaut RE. Age-related responses of the microcirculation to ischemia-reperfusion and inflammation. Pathophysiology. 2001 Aug; 8(1):1-10. PMID: 11476967.
      View in: PubMed
    49. Rumbaut RE, Wang J, Huxley VH. Differential effects of L-NAME on rat venular hydraulic conductivity. Am J Physiol Heart Circ Physiol. 2000 Oct; 279(4):H2017-23. PMID: 11009493.
      View in: PubMed
    50. Huxley VH, Rumbaut RE. The microvasculature as a dynamic regulator of volume and solute exchange. Clin Exp Pharmacol Physiol. 2000 Oct; 27(10):847-54. PMID: 11022981.
      View in: PubMed
    51. Rumbaut RE, Sial AJ. Differential phototoxicity of fluorescent dye-labeled albumin conjugates. Microcirculation. 1999 Sep; 6(3):205-13. PMID: 10501094.
      View in: PubMed
    52. Rumbaut RE, Harris NR, Sial AJ, Huxley VH, Granger DN. Leakage responses to L-NAME differ with the fluorescent dye used to label albumin. Am J Physiol. 1999 01; 276(1):H333-9. PMID: 9887048.
      View in: PubMed
    53. King PD, Rumbaut R, Sanchez C. Pulmonary manifestations of chronic liver disease. Dig Dis. 1996 Mar-Apr; 14(2):73-82. PMID: 8653939.
      View in: PubMed
    54. Rumbaut RE, McKay MK, Huxley VH. Capillary hydraulic conductivity is decreased by nitric oxide synthase inhibition. Am J Physiol. 1995 May; 268(5 Pt 2):H1856-61. PMID: 7539589.
      View in: PubMed
    55. Rumbaut RE, Kroll MH, Gyorkey F, Schafer AI. Acquired platelet storage pool deficiency due to severe valvular disease corrected by prosthetic valve replacement. Am J Hematol. 1994 Mar; 45(3):272-3. PMID: 8296805.
      View in: PubMed
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