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RICHARD N SIFERS

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
DivisionPathology
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Physiology & Biophysics
    DivisionMolecular Physiology & Biophysics

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentHuffington Center on Aging
    DivisionHuffington Ctr on Aging

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentHuman Genome Sequencing Center
    DivisionHuman Genome Sequencing Center


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    F32HL007343     (SIFERS, RICHARD NORMAN)Mar 15, 1986
    NIH/NHLBI
    ALPHA-1-ANTITRYPSIN DEFICIENCY
    Role: Principal Investigator

    R29DK042806     (SIFERS, RICHARD NORMAN)May 1, 1991 - Oct 31, 1996
    NIH/NIDDK
    PREGOLGI DEGRADATION OF MUTANT SECRETORY PROTEINS
    Role: Principal Investigator

    R01HL062553     (SIFERS, RICHARD NORMAN)Feb 1, 2000 - Jan 31, 2005
    NIH/NHLBI
    PATHOBIOGENESIS OF HERITABLE PULMONARY EMPHYSEMA
    Role: Principal Investigator

    R01DK064232     (SIFERS, RICHARD NORMAN)Sep 15, 2004 - Jun 30, 2011
    NIH/NIDDK
    Post-translational Surveillance of Genome Expression
    Role: Principal Investigator

    K12GM084897     (SLAUGHTER, GAYLE)Aug 1, 2008 - Jul 31, 2017
    NIH/NIGMS
    Research Education and Career Horizons Program
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wang L, Adamski CJ, Bondar VV, Craigen E, Collette JR, Pang K, Han K, Jain A, Y Jung S, Liu Z, Sifers RN, Holder JL, Zoghbi HY. A kinome-wide RNAi screen identifies ERK2 as a druggable regulator of Shank3 stability. Mol Psychiatry. 2019 Jan 29. PMID: 30696942.
      View in: PubMed
    2. di Ronza A, Bajaj L, Sharma J, Sanagasetti D, Lotfi P, Adamski CJ, Collette J, Palmieri M, Amawi A, Popp L, Chang KT, Meschini MC, Leung HE, Segatori L, Simonati A, Sifers RN, Santorelli FM, Sardiello M. CLN8 is an endoplasmic reticulum cargo receptor that regulates lysosome biogenesis. Nat Cell Biol. 2018 12; 20(12):1370-1377. PMID: 30397314.
      View in: PubMed
    3. Mamrosh JL, Lee JM, Wagner M, Stambrook PJ, Whitby RJ, Sifers RN, Wu SP, Tsai MJ, DeMayo FJ, Moore DD. Correction: Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution. Elife. 2015 Jul 24; 4:e10084. PMID: 26205891.
      View in: PubMed
    4. Mamrosh JL, Lee JM, Wagner M, Stambrook PJ, Whitby RJ, Sifers RN, Wu SP, Tsai MJ, Demayo FJ, Moore DD. Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution. Elife. 2014 Apr 15; 3:e01694. PMID: 24737860.
      View in: PubMed
    5. Iannotti MJ, Figard L, Sokac AM, Sifers RN. A Golgi-localized mannosidase (MAN1B1) plays a non-enzymatic gatekeeper role in protein biosynthetic quality control. J Biol Chem. 2014 Apr 25; 289(17):11844-58. PMID: 24627495.
      View in: PubMed
    6. Pan S, Cheng X, Chen H, Castro PD, Ittmann MM, Hutson AW, Zapata SK, Sifers RN. ERManI is a target of miR-125b and promotes transformation phenotypes in hepatocellular carcinoma (HCC). PLoS One. 2013; 8(8):e72829. PMID: 23940818.
      View in: PubMed
    7. Sifers RN. Resurrecting the protein fold for disease intervention. Chem Biol. 2013 Mar 21; 20(3):298-300. PMID: 23521788.
      View in: PubMed
    8. Pan S, Cheng X, Sifers RN. Golgi-situated endoplasmic reticulum a-1, 2-mannosidase contributes to the retrieval of ERAD substrates through a direct interaction with ?-COP. Mol Biol Cell. 2013 Apr; 24(8):1111-21. PMID: 23427261.
      View in: PubMed
    9. Fong JJ, Nguyen BL, Bridger R, Medrano EE, Wells L, Pan S, Sifers RN. ß-N-Acetylglucosamine (O-GlcNAc) is a novel regulator of mitosis-specific phosphorylations on histone H3. J Biol Chem. 2012 Apr 06; 287(15):12195-203. PMID: 22371497.
      View in: PubMed
    10. Pan S, Wang S, Utama B, Huang L, Blok N, Estes MK, Moremen KW, Sifers RN. Golgi localization of ERManI defines spatial separation of the mammalian glycoprotein quality control system. Mol Biol Cell. 2011 Aug 15; 22(16):2810-22. PMID: 21697506.
      View in: PubMed
    11. Pan S, Iannotti MJ, Sifers RN. Analysis of serpin secretion, misfolding, and surveillance in the endoplasmic reticulum. Methods Enzymol. 2011; 499:1-16. PMID: 21683246.
      View in: PubMed
    12. Sifers RN. Intracellular processing of alpha1-antitrypsin. Proc Am Thorac Soc. 2010 Nov; 7(6):376-80. PMID: 21030516.
      View in: PubMed
    13. Sifers RN. Medicine. Clearing conformational disease. Science. 2010 Jul 09; 329(5988):154-5. PMID: 20616258.
      View in: PubMed
    14. Sifers RN. Manipulating proteostasis. Nat Chem Biol. 2010 Jun; 6(6):400-1. PMID: 20479748.
      View in: PubMed
    15. Sifers RN. Defining the ERAD connection: assembly required. Cell Cycle. 2009 Dec 15; 8(24):4026-7. PMID: 19959932.
      View in: PubMed
    16. Pan S, Huang L, McPherson J, Muzny D, Rouhani F, Brantly M, Gibbs R, Sifers RN. Single nucleotide polymorphism-mediated translational suppression of endoplasmic reticulum mannosidase I modifies the onset of end-stage liver disease in alpha1-antitrypsin deficiency. Hepatology. 2009 Jul; 50(1):275-81. PMID: 19444872.
      View in: PubMed
    17. Termine DJ, Moremen KW, Sifers RN. The mammalian UPR boosts glycoprotein ERAD by suppressing the proteolytic downregulation of ER mannosidase I. J Cell Sci. 2009 Apr 01; 122(Pt 7):976-84. PMID: 19258393.
      View in: PubMed
    18. Pan S, Wang R, Zhou X, Corvera J, Kloc M, Sifers R, Gallick GE, Lin SH, Kuang J. Extracellular Alix regulates integrin-mediated cell adhesions and extracellular matrix assembly. EMBO J. 2008 Aug 06; 27(15):2077-90. PMID: 18636094.
      View in: PubMed
    19. Mallya M, Phillips RL, Saldanha SA, Gooptu B, Brown SC, Termine DJ, Shirvani AM, Wu Y, Sifers RN, Abagyan R, Lomas DA. Small molecules block the polymerization of Z alpha1-antitrypsin and increase the clearance of intracellular aggregates. J Med Chem. 2007 Nov 01; 50(22):5357-63. PMID: 17918823.
      View in: PubMed
    20. Wu Y, Termine DJ, Swulius MT, Moremen KW, Sifers RN. Human endoplasmic reticulum mannosidase I is subject to regulated proteolysis. J Biol Chem. 2007 Feb 16; 282(7):4841-9. PMID: 17166854.
      View in: PubMed
    21. Termine D, Wu Y, Liu Y, Sifers RN. Alpha1-antitrypsin as model to assess glycan function in endoplasmic reticulum. Methods. 2005 Apr; 35(4):348-53. PMID: 15804606.
      View in: PubMed
    22. Mast SW, Diekman K, Karaveg K, Davis A, Sifers RN, Moremen KW. Human EDEM2, a novel homolog of family 47 glycosidases, is involved in ER-associated degradation of glycoproteins. Glycobiology. 2005 Apr; 15(4):421-36. PMID: 15537790.
      View in: PubMed
    23. Sifers RN. Insights into checkpoint capacity. Nat Struct Mol Biol. 2004 Feb; 11(2):108-9. PMID: 14749767.
      View in: PubMed
    24. Wu Y, Swulius MT, Moremen KW, Sifers RN. Elucidation of the molecular logic by which misfolded alpha 1-antitrypsin is preferentially selected for degradation. Proc Natl Acad Sci U S A. 2003 Jul 08; 100(14):8229-34. PMID: 12815101.
      View in: PubMed
    25. Sifers RN. Cell biology. Protein degradation unlocked. Science. 2003 Feb 28; 299(5611):1330-1. PMID: 12610289.
      View in: PubMed
    26. Han B, Luo G, Shi ZZ, Barrios R, Atwood D, Liu W, Habib GM, Sifers RN, Corry DB, Lieberman MW. Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo. Am J Pathol. 2002 Aug; 161(2):481-90. PMID: 12163373.
      View in: PubMed
    27. Cabral CM, Liu Y, Moremen KW, Sifers RN. Organizational diversity among distinct glycoprotein endoplasmic reticulum-associated degradation programs. Mol Biol Cell. 2002 Aug; 13(8):2639-50. PMID: 12181335.
      View in: PubMed
    28. Davis RL, Shrimpton AE, Carrell RW, Lomas DA, Gerhard L, Baumann B, Lawrence DA, Yepes M, Kim TS, Ghetti B, Piccardo P, Takao M, Lacbawan F, Muenke M, Sifers RN, Bradshaw CB, Kent PF, Collins GH, Larocca D, Holohan PD. Association between conformational mutations in neuroserpin and onset and severity of dementia. Lancet. 2002 Jun 29; 359(9325):2242-7. PMID: 12103288.
      View in: PubMed
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