TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
Houston, TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Ophthalmology

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    R01EY006656     (HURWITZ, RICHARD L)Jul 1, 1986 - Nov 30, 1996
    Role: Principal Investigator

    R21CA097762     (HURWITZ, RICHARD L)Jul 22, 2002 - Jun 30, 2005
    Gene Therapy for Retinoblastoma
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Liu A, Ildefonso CJ, Bond WS, Hurwitz MY, Hurwitz RL. Inhibitors of metalloprotease, ?-sectretase, protein kinase C and Rho kinase inhibit wild-type adenoviral replication. PLoS One. 2020; 15(7):e0236175. PMID: 32697798.
      Citations:    Fields:    Translation:HumansCells
    2. George A, Dinu B, Estrada N, Minard CG, Hurwitz R, Mahoney DH, Yates AM, Vaughan M, Carmouche A, Airewele G, Kirk SE, Fasipe T, Uwaezuoke P, Ware RE. Novel dose escalation to predict treatment with hydroxyurea (NDEPTH): A randomized controlled trial of a dose-prediction equation to determine maximum tolerated dose of hydroxyurea in pediatric sickle cell disease. Am J Hematol. 2020 09; 95(9):E242-E244. PMID: 32472611.
      Citations:    Fields:    Translation:Humans
    3. Akinfenwa PY, Bond WS, Ildefonso CJ, Hurwitz MY, Hurwitz RL. Versican G1 domain enhances adenoviral-mediated transgene expression and can be modulated by inhibitors of the Janus kinase (JAK)/STAT and Src family kinase pathways. J Biol Chem. 2017 09 01; 292(35):14381-14390. PMID: 28684419.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    4. Bond WS, Akinfenwa PY, Perlaky L, Hurwitz MY, Hurwitz RL, Chévez-Barrios P. Tumorspheres but not adherent cells derived from retinoblastoma tumors are of malignant origin. PLoS One. 2013; 8(6):e63519. PMID: 23826078.
      Citations: 8     Fields:    Translation:HumansCells
    5. Liu Z, Zhao X, Mao H, Baxter PA, Huang Y, Yu L, Wadhwa L, Su JM, Adesina A, Perlaky L, Hurwitz M, Idamakanti N, Police SR, Hallenbeck PL, Hurwitz RL, Lau CC, Chintagumpala M, Blaney SM, Li XN. Intravenous injection of oncolytic picornavirus SVV-001 prolongs animal survival in a panel of primary tumor-based orthotopic xenograft mouse models of pediatric glioma. Neuro Oncol. 2013 Sep; 15(9):1173-85. PMID: 23658322.
      Citations: 33     Fields:    Translation:AnimalsCells
    6. Hurwitz RL. A new vision of mesenchymal stromal cells. Mol Ther. 2012 Nov; 20(11):2017-8. PMID: 23131854.
      Citations:    Fields:    Translation:HumansAnimals
    7. Ildefonso CJ, Bond WS, Al-Tawashi AR, Hurwitz MY, Hurwitz RL. The liberation of CD44 intracellular domain modulates adenoviral vector transgene expression. J Biol Chem. 2012 Sep 21; 287(39):32697-707. PMID: 22865879.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    8. Wadhwa L, Bond WS, Perlaky L, Overbeek PA, Hurwitz MY, Chévez-Barrios P, Hurwitz RL. Embryonic retinal tumors in SV40 T-Ag transgenic mice contain CD133+ tumor-initiating cells. Invest Ophthalmol Vis Sci. 2012 Jun 08; 53(7):3454-62. PMID: 22562503.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    9. Bond WS, Wadhwa L, Perlaky L, Penland RL, Hurwitz MY, Hurwitz RL, Chèvez-Barrios P. Establishment and propagation of human retinoblastoma tumors in immune deficient mice. J Vis Exp. 2011 Aug 04; (54). PMID: 21847079.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    10. Yu L, Baxter PA, Zhao X, Liu Z, Wadhwa L, Zhang Y, Su JM, Tan X, Yang J, Adesina A, Perlaky L, Hurwitz M, Idamakanti N, Police SR, Hallenbeck PL, Blaney SM, Chintagumpala M, Hurwitz RL, Li XN. A single intravenous injection of oncolytic picornavirus SVV-001 eliminates medulloblastomas in primary tumor-based orthotopic xenograft mouse models. Neuro Oncol. 2011 Jan; 13(1):14-27. PMID: 21075780.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    11. Ildefonso CJ, Kong L, Leen A, Chai SJ, Petrochelli V, Chintagumpala M, Hurwitz MY, Chévez-Barrios P, Hurwitz RL. Absence of systemic immune response to adenovectors after intraocular administration to children with retinoblastoma. Mol Ther. 2010 Oct; 18(10):1885-90. PMID: 20606647.
      Citations: 12     Fields:    Translation:HumansCellsCTClinical Trials
    12. Wadhwa L, Hurwitz MY, Chévez-Barrios P, Hurwitz RL. Treatment of invasive retinoblastoma in a murine model using an oncolytic picornavirus. Cancer Res. 2007 Nov 15; 67(22):10653-6. PMID: 18006805.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    13. Chintagumpala M, Chevez-Barrios P, Paysse EA, Plon SE, Hurwitz R. Retinoblastoma: review of current management. Oncologist. 2007 Oct; 12(10):1237-46. PMID: 17962617.
      Citations: 59     Fields:    Translation:Humans
    14. Chaudhuri SR, Mallam JN, Chévez-Barrios P, Wadhwa L, Ng P, Hurwitz MY, Hurwitz RL. Modulation of adenoviral transduction in vitro and in vivo by hyaluronan and its receptor CD44. Mol Ther. 2007 Mar; 15(3):566-70. PMID: 17180120.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    15. Chong EM, Coffee RE, Chintagumpala M, Hurwitz RL, Hurwitz MY, Chévez-Barrios P. Extensively necrotic retinoblastoma is associated with high-risk prognostic factors. Arch Pathol Lab Med. 2006 Nov; 130(11):1669-72. PMID: 17076529.
      Citations: 9     Fields:    Translation:Humans
    16. Chévez-Barrios P, Chintagumpala M, Mieler W, Paysse E, Boniuk M, Kozinetz C, Hurwitz MY, Hurwitz RL. Response of retinoblastoma with vitreous tumor seeding to adenovirus-mediated delivery of thymidine kinase followed by ganciclovir. J Clin Oncol. 2005 Nov 01; 23(31):7927-35. PMID: 16258092.
      Citations: 44     Fields:    Translation:HumansCellsCTClinical Trials
    17. Mallam JN, Hurwitz MY, Mahoney T, Chévez-Barrios P, Hurwitz RL. Efficient gene transfer into retinal cells using adenoviral vectors: dependence on receptor expression. Invest Ophthalmol Vis Sci. 2004 Jun; 45(6):1680-7. PMID: 15161826.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    18. Hurwitz RL, Chévez-Barrios P, Boniuk M, Chintagumpala M, Hurwitz MY. Retinoblastoma: from bench to bedside. Expert Rev Mol Med. 2003 Jan 07; 5(1):1-14. PMID: 14987394.
      Citations: 4     Fields:    Translation:HumansAnimals
    19. Hozier J, Lindquist L, Hurwitz R, LeBien T, Kersey J. Evolution of cultured leukemic cell lines monitored by chromosomal and immunologic analysis. Int J Cancer. 1980 Sep 15; 26(3):281-4. PMID: 6945291.
      Citations: 1     Fields:    Translation:HumansCells
    20. Hurwitz RL, Schreinemachers D, Kersey JH. Elimination of platelets from mononuclear cell preparations using heat-killed yeast. Exp Hematol. 1979 Feb; 7(2):81-6. PMID: 371975.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    21. Hurwitz R, Hozier J, LeBien T, Minowada J, Gajl-Peczalska K, Kubonishi I, Kersey J. Characterization of a leukemic cell line of the pre-B phenotype. Int J Cancer. 1979 Feb; 23(2):174-80. PMID: 83966.
      Citations: 52     Fields:    Translation:HumansCells
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