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Richard H. Finnell

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentCenter for Precision Environmental Health
    DivisionCenter for Precision Env Health

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-General Medicine


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    R03MH042149     (FINNELL, RICHARD H.)Aug 1, 1986 - Jul 31, 1987
    NIH/NIMH
    HEAT SHOCK PROTEINS AND ABNORMAL NEURAL DEVELOPMENT
    Role: Principal Investigator

    R01ES004326     (FINNELL, RICHARD H.)Jan 15, 1988 - Jun 30, 1991
    NIH/NIEHS
    THE HEAT SHOCK RESPONSE: POTENTIAL TO SCREEN TERATOGENS
    Role: Principal Investigator

    R01DE011303     (FINNELL, RICHARD H.)May 1, 1994 - Apr 30, 1999
    NIH/NIDCR
    ANTIEPILETIC DRUG SYNDROME--A MOLECULAR ANALYSIS
    Role: Principal Investigator

    R01ES007165     (FINNELL, RICHARD H.)Jul 1, 1994 - Jun 30, 1998
    NIH/NIEHS
    GENE EXPRESSION DURING MURINE NEURAL TUBE CLOSURE
    Role: Principal Investigator

    R01HD035396     (FINNELL, RICHARD H.)Apr 1, 1997 - Mar 31, 2002
    NIH/NICHD
    FOLATE RECEPTOR KNOCKOUTS, ARSENATE AND BIRTH DEFECTS
    Role: Principal Investigator

    R01DE013613     (FINNELL, RICHARD H.)May 1, 1999 - Apr 30, 2004
    NIH/NIDCR
    FOLATE RECEPTORS IN CRANIOFACIAL MALFORMATIONS
    Role: Principal Investigator

    R01DE016315     (FINNELL, RICHARD H.)Aug 1, 2005 - Oct 30, 2010
    NIH/NIDCR
    GENETIC REGULATION OF FOLATE RESPONSIVE BIRTH DEFECTS
    Role: Principal Investigator

    R13NS066584     (FINNELL, RICHARD H.)Jul 1, 2009 - Jun 30, 2010
    NIH/NINDS
    Sixth International Neural Tube Defects Conference
    Role: Principal Investigator

    U13DP003269     (FINNELL, RICHARD H.)Sep 30, 2011 - Sep 29, 2016
    CDC/NCCDPHP
    7TH INTERNATIONAL CONFERENCE ON NEURAL TUBE DEFECTS (NTDS)
    Role: Principal Investigator

    R21HD072251     (FINNELL, RICHARD H.)Aug 1, 2012 - Jul 31, 2014
    NIH/NICHD
    Genetic Regulation of Valproic Acid Teratogenicity
    Role: Principal Investigator

    R01ES021006     (FINNELL, RICHARD H.)Aug 16, 2012 - Jun 30, 2015
    NIH/NIEHS
    Study of Neural Tube Defects Etiology: Genome and Exposome
    Role: Principal Investigator

    R13HD084156     (FINNELL, RICHARD H.)Aug 1, 2015 - Jul 31, 2016
    NIH/NICHD
    2015 International Conference on Neural Tube Defects
    Role: Principal Investigator

    R01HD081216     (FINNELL, RICHARD H.)Aug 10, 2015 - Jun 30, 2020
    NIH/NICHD
    Folic Acid, Parental Mutation Rates and the Risk for Neural Tube Defects
    Role: Principal Investigator

    R01HD083809     (FINNELL, RICHARD H.)Feb 15, 2016 - Jan 31, 2021
    NIH/NICHD
    INTERVENTION STRATEGIES FOR NON-FOLATE RESPONSIVE NEURAL TUBE DEFECTS
    Role: Principal Investigator

    R13HD093414     (FINNELL, RICHARD H.)Jul 16, 2017 - Jun 30, 2018
    NIH/NICHD
    2017 10th International Conference on Neural Tube Defects
    Role: Principal Investigator

    R01HD093758     (FINNELL, RICHARD H.)Sep 1, 2018 - Jun 30, 2023
    NIH/NICHD
    The Role of GPR161 in the Etiology of Neural Tube Defects
    Role: Principal Investigator

    R01HD095520     (LARIN, KIRILL V)Sep 1, 2018 - Jun 30, 2023
    NIH/NICHD
    Biomechanics of Neural Tube Development using Brillouin-OCT Multimodality
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Li H, Wang X, Zhao H, Wang F, Bao Y, Guo J, Chang S, Wu L, Cheng H, Chen S, Zou J, Cui X, Niswander L, Finnell RH, Wang H, Zhang T. Low folate concentration impacts mismatch repair deficiency in neural tube defects. Epigenomics. 2019 Nov 26. PMID: 31769301.
      View in: PubMed
    2. Cabrera RM, Souder JP, Steele JW, Yeo L, Tukeman G, Gorelick DA, Finnell RH. The antagonism of folate receptor by dolutegravir: developmental toxicity reduction by supplemental folic acid. AIDS. 2019 Nov 01; 33(13):1967-1976. PMID: 31259764.
      View in: PubMed
    3. Chen Z, Lei Y, Zheng Y, Aguiar-Pulido V, Ross ME, Peng R, Jin L, Zhang T, Finnell RH, Wang H. Author Correction: Threshold for neural tube defect risk by accumulated singleton loss-of-function variants. Cell Res. 2019 Sep; 29(9):776. PMID: 31346254.
      View in: PubMed
    4. López-Escobar B, Wlodarczyk BJ, Caro-Vega J, Lin Y, Finnell RH, Ybot-González P. The interaction of maternal diabetes with mutations that affect folate metabolism and how they affect the development of neural tube defects in mice. Dev Dyn. 2019 Oct; 248(10):900-917. PMID: 31361376.
      View in: PubMed
    5. Alam C, Aufreiter S, Georgiou CJ, Hoque MT, Finnell RH, O'Connor DL, Goldman ID, Bendayan R. Upregulation of reduced folate carrier by vitamin D enhances brain folate uptake in mice lacking folate receptor alpha. Proc Natl Acad Sci U S A. 2019 Aug 27; 116(35):17531-17540. PMID: 31405972.
      View in: PubMed
    6. Jenkins MM, Almli LM, Pangilinan F, Chong JX, Blue EE, Shapira SK, White J, McGoldrick D, Smith JD, Mullikin JC, Bean CJ, Nembhard WN, Lou XY, Shaw GM, Romitti PA, Keppler-Noreuil K, Yazdy MM, Kay DM, Carter TC, Olshan AF, Moore KJ, Nascone-Yoder N, Finnell RH, Lupo PJ, Feldkamp ML, Nickerson DA, Bamshad MJ, Brody LC, Reefhuis J. Exome sequencing of family trios from the National Birth Defects Prevention Study: Tapping into a rich resource of genetic and environmental data. Birth Defects Res. 2019 Jul 21. PMID: 31328417.
      View in: PubMed
    7. Steele JW, Bayliss S, Bayliss J, Lin YL, Wlodarczyk BJ, Cabrera RM, Asfaw YG, Cummings TJ, Finnell RH, George TM. Heritable Spina Bifida in Sheep: A Potential Model for Fetal Repair of Myelomeningocele. J Pediatr Surg. 2019 Jun 29. PMID: 31301886.
      View in: PubMed
    8. Kousa YA, Zhu H, Fakhouri WD, Lei Y, Kinoshita A, Roushangar RR, Patel NK, Agopian AJ, Yang W, Leslie EJ, Busch TD, Mansour TA, Li X, Smith AL, Li EB, Sharma DB, Williams TJ, Chai Y, Amendt BA, Liao EC, Mitchell LE, Bassuk AG, Gregory S, Ashley-Koch A, Shaw GM, Finnell RH, Schutte BC. The TFAP2A-IRF6-GRHL3 genetic pathway is conserved in neurulation. Hum Mol Genet. 2019 05 15; 28(10):1726-1737. PMID: 30689861.
      View in: PubMed
    9. Hoang TT, Lei Y, Mitchell LE, Sharma SV, Swartz MD, Waller DK, Finnell RH, Benjamin RH, Browne ML, Canfield MA, Lupo PJ, McKenzie P, Shaw GM, Agopian AJ. Maternal genetic markers for risk of celiac disease and their potential association with neural tube defects in offspring. Mol Genet Genomic Med. 2019 Jun; 7(6):e688. PMID: 30968606.
      View in: PubMed
    10. Hoang TT, Lei Y, Mitchell LE, Sharma SV, Swartz MD, Waller DK, Finnell RH, Benjamin RH, Browne ML, Canfield MA, Lupo PJ, McKenzie P, Shaw G, Agopian AJ. Maternal Lactase Polymorphism (rs4988235) Is Associated with Neural Tube Defects in Offspring in the National Birth Defects Prevention Study. J Nutr. 2019 02 01; 149(2):295-303. PMID: 30689919.
      View in: PubMed
    11. Lei Y, Kim SE, Chen Z, Cao X, Zhu H, Yang W, Shaw GM, Zheng Y, Zhang T, Wang HY, Finnell RH. Variants identified in PTK7 associated with neural tube defects. Mol Genet Genomic Med. 2019 04; 7(4):e00584. PMID: 30689296.
      View in: PubMed
    12. Martin JB, Muccioli M, Herman K, Finnell RH, Plageman TF. Folic acid modifies the shape of epithelial cells during morphogenesis via a Folr1 and MLCK dependent mechanism. Biol Open. 2019 Jan 22; 8(1). PMID: 30670450.
      View in: PubMed
    13. Xie Y, Ma A, Wang B, Peng R, Jing Y, Wang D, Finnell RH, Qiao B, Wang Y, Wang H, Zheng Y. Rare mutations of ADAM17 from TOFs induce hypertrophy in human embryonic stem cell-derived cardiomyocytes via HB-EGF signaling. Clin Sci (Lond). 2019 01 31; 133(2):225-238. PMID: 30610007.
      View in: PubMed
    14. Kim SE, Lei Y, Hwang SH, Wlodarczyk BJ, Mukhopadhyay S, Shaw GM, Ross ME, Finnell RH. Dominant negative GPR161 rare variants are risk factors of human spina bifida. Hum Mol Genet. 2019 01 15; 28(2):200-208. PMID: 30256984.
      View in: PubMed
    15. Wang YM, Zheng YF, Yang SY, Yang ZM, Zhang LN, He YQ, Gong XH, Liu D, Finnell RH, Qiu ZL, Du YS, Wang HY. MicroRNA-197 controls ADAM10 expression to mediate MeCP2's role in the differentiation of neuronal progenitors. Cell Death Differ. 2019 Oct; 26(10):1863-1879. PMID: 30560934.
      View in: PubMed
    16. Walker DI, Perry-Walker K, Finnell RH, Pennell KD, Tran V, May RC, McElrath TF, Meador KJ, Pennell PB, Jones DP. Metabolome-wide association study of anti-epileptic drug treatment during pregnancy. Toxicol Appl Pharmacol. 2019 01 15; 363:122-130. PMID: 30521819.
      View in: PubMed
    17. Avagliano L, Massa V, George TM, Qureshy S, Bulfamante GP, Finnell RH. Overview on neural tube defects: From development to physical characteristics. Birth Defects Res. 2019 Nov 15; 111(19):1455-1467. PMID: 30421543.
      View in: PubMed
    18. Lin YL, Bialer M, Cabrera RM, Finnell RH, Wlodarczyk BJ. Teratogenicity of valproic acid and its constitutional isomer, amide derivative valnoctamide in mice. Birth Defects Res. 2019 Aug 15; 111(14):1013-1023. PMID: 30325584.
      View in: PubMed
    19. Zhang J, Raghunathan R, Rippy J, Wu C, Finnell RH, Larin KV, Scarcelli G. Tissue biomechanics during cranial neural tube closure measured by Brillouin microscopy and optical coherence tomography. Birth Defects Res. 2019 Aug 15; 111(14):991-998. PMID: 30239173.
      View in: PubMed
    20. Conde-Vancells J, Vazquez-Chantada M, McCollum CW, Bondesson M, Kalasekar SM, Wlodarczyk BJ, Gustafsson JÅ, Cabrera RM, Finnell RH. Combining mouse embryonic stem cells and zebrafish embryos to evaluate developmental toxicity of chemical exposure. Reprod Toxicol. 2018 10; 81:220-228. PMID: 30103011.
      View in: PubMed
    21. Zhou X, Xu M, Zeng W, Chen Z, Lu G, Gong Y, Finnell RH, Xiao H, Qiao B, Wang H. Combined effects of FH (E404D) and ACOX2 (R409H) cause metabolic defects in primary cardiac malignant tumor. Cell Death Discov. 2018; 4:18. PMID: 30062063.
      View in: PubMed
    22. Chen Z, Lei Y, Zheng Y, Aguiar-Pulido V, Ross ME, Peng R, Jin L, Zhang T, Finnell RH, Wang H. Threshold for neural tube defect risk by accumulated singleton loss-of-function variants. Cell Res. 2018 10; 28(10):1039-1041. PMID: 29976953.
      View in: PubMed
    23. Wang H, Zhao S, Finnell RH, George T, Cooney AJ. Generation of integration-free induced pluripotent stem cells from a patient with spina bifida. Stem Cell Res. 2018 08; 31:27-30. PMID: 30007220.
      View in: PubMed
    24. Dong Y, Wang L, Lei Y, Yang N, Cabrera RM, Finnell RH, Ren A. Gene variants in the folate pathway are associated with increased levels of folate receptor autoantibodies. Birth Defects Res. 2018 07 17; 110(12):973-981. PMID: 29732742.
      View in: PubMed
    25. Gao X, Finnell RH, Wang H, Zheng Y. Network correlation analysis revealed potential new mechanisms for neural tube defects beyond folic acid. Birth Defects Res. 2018 07 17; 110(12):982-993. PMID: 29732722.
      View in: PubMed
    26. Kim J, Lei Y, Guo J, Kim SE, Wlodarczyk BJ, Cabrera RM, Lin YL, Nilsson TK, Zhang T, Ren A, Wang L, Yuan Z, Zheng YF, Wang HY, Finnell RH. Formate rescues neural tube defects caused by mutations in Slc25a32. Proc Natl Acad Sci U S A. 2018 05 01; 115(18):4690-4695. PMID: 29666258.
      View in: PubMed
    27. Chen Z, Lei Y, Cao X, Zheng Y, Wang F, Bao Y, Peng R, Finnell RH, Zhang T, Wang H. Genetic analysis of Wnt/PCP genes in neural tube defects. BMC Med Genomics. 2018 04 04; 11(1):38. PMID: 29618362.
      View in: PubMed
    28. Tian T, Wang L, Shen Y, Zhang B, Finnell RH, Ren A. Hypomethylation of GRHL3 gene is associated with the occurrence of neural tube defects. Epigenomics. 2018 07; 10(7):891-901. PMID: 29587534.
      View in: PubMed
    29. Wang L, Xiao Y, Tian T, Jin L, Lei Y, Finnell RH, Ren A. Digenic variants of planar cell polarity genes in human neural tube defect patients. Mol Genet Metab. 2018 05; 124(1):94-100. PMID: 29573971.
      View in: PubMed
    30. Chen Z, Kuang L, Finnell RH, Wang H. Genetic and functional analysis of SHROOM1-4 in a Chinese neural tube defect cohort. Hum Genet. 2018 Mar; 137(3):195-202. PMID: 29423651.
      View in: PubMed
    31. Niedzwiecki MM, Liu X, Zhu H, Hall MN, Slavkovich V, Ilievski V, Levy D, Siddique AB, Kibriya MG, Parvez F, Islam T, Ahmed A, Navas-Acien A, Graziano JH, Finnell RH, Ahsan H, Gamble MV. Serum homocysteine, arsenic methylation, and arsenic-induced skin lesion incidence in Bangladesh: A one-carbon metabolism candidate gene study. Environ Int. 2018 04; 113:133-142. PMID: 29421402.
      View in: PubMed
    32. Waller DK, Hashmi SS, Hoyt AT, Duong HT, Tinker SC, Gallaway MS, Olney RS, Finnell RH, Hecht JT, Canfield MA. Maternal report of fever from cold or flu during early pregnancy and the risk for noncardiac birth defects, National Birth Defects Prevention Study, 1997-2011. Birth Defects Res. 2018 03 01; 110(4):342-351. PMID: 29094488.
      View in: PubMed
    33. Alam C, Hoque MT, Finnell RH, Goldman ID, Bendayan R. Regulation of Reduced Folate Carrier (RFC) by Vitamin D Receptor at the Blood-Brain Barrier. Mol Pharm. 2017 11 06; 14(11):3848-3858. PMID: 28885847.
      View in: PubMed
    34. Vichier-Guerre C, Parker M, Pomerantz Y, Finnell RH, Cabrera RM. Impact of selective serotonin reuptake inhibitors on neural crest stem cell formation. Toxicol Lett. 2017 Nov 05; 281:20-25. PMID: 28844482.
      View in: PubMed
    35. Li P, Huang L, Zheng Y, Pan X, Peng R, Jiang Y, Finnell RH, Li H, Qiao B, Wang HY. A missense mutation in TCN2 is associated with decreased risk for congenital heart defects and may increase cellular uptake of vitamin B12 via Megalin. Oncotarget. 2017 Aug 15; 8(33):55216-55229. PMID: 28903415.
      View in: PubMed
    36. Toriyama M, Toriyama M, Wallingford JB, Finnell RH. Folate-dependent methylation of septins governs ciliogenesis during neural tube closure. FASEB J. 2017 08; 31(8):3622-3635. PMID: 28432198.
      View in: PubMed
    37. Lu HC, Tan Q, Rousseaux MW, Wang W, Kim JY, Richman R, Wan YW, Yeh SY, Patel JM, Liu X, Lin T, Lee Y, Fryer JD, Han J, Chahrour M, Finnell RH, Lei Y, Zurita-Jimenez ME, Ahimaz P, Anyane-Yeboa K, Van Maldergem L, Lehalle D, Jean-Marcais N, Mosca-Boidron AL, Thevenon J, Cousin MA, Bro DE, Lanpher BC, Klee EW, Alexander N, Bainbridge MN, Orr HT, Sillitoe RV, Ljungberg MC, Liu Z, Schaaf CP, Zoghbi HY. Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans. Nat Genet. 2017 Apr; 49(4):527-536. PMID: 28288114.
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    38. Bibi D, Mawasi H, Nocentini A, Supuran CT, Wlodarczyk B, Finnell RH, Bialer M. Design and Comparative Evaluation of the Anticonvulsant Profile, Carbonic-Anhydrate Inhibition and Teratogenicity of Novel Carbamate Derivatives of Branched Aliphatic Carboxylic Acids with 4-Aminobenzensulfonamide. Neurochem Res. 2017 Jul; 42(7):1972-1982. PMID: 28275953.
      View in: PubMed
    39. Chen X, An Y, Gao Y, Guo L, Rui L, Xie H, Sun M, Lam Hung S, Sheng X, Zou J, Bao Y, Guan H, Niu B, Li Z, Finnell RH, Gusella JF, Wu BL, Zhang T. Rare Deleterious PARD3 Variants in the aPKC-Binding Region are Implicated in the Pathogenesis of Human Cranial Neural Tube Defects Via Disrupting Apical Tight Junction Formation. Hum Mutat. 2017 04; 38(4):378-389. PMID: 27925688.
      View in: PubMed
    40. Akimova D, Wlodarczyk BJ, Lin Y, Ross ME, Finnell RH, Chen Q, Gross SS. Metabolite profiling of whole murine embryos reveals metabolic perturbations associated with maternal valproate-induced neural tube closure defects. Birth Defects Res. 2017 01 30; 109(2):106-119. PMID: 27860192.
      View in: PubMed
    41. Ross ME, Mason CE, Finnell RH. Genomic approaches to the assessment of human spina bifida risk. Birth Defects Res. 2017 01 30; 109(2):120-128. PMID: 27883265.
      View in: PubMed
    42. Bayer CL, Wlodarczyk BJ, Finnell RH, Emelianov SY. Ultrasound-guided spectral photoacoustic imaging of hemoglobin oxygenation during development. Biomed Opt Express. 2017 Feb 01; 8(2):757-763. PMID: 28270982.
      View in: PubMed
    43. Yang N, Wang L, Finnell RH, Li Z, Jin L, Zhang L, Cabrera RM, Ye R, Ren A. Corrigendum for: Levels of folate receptor autoantibodies in maternal and cord blood and risk of neural tube defects in a Chinese population, 106:685-695 (10.1002/bdra.23517). Birth Defects Res A Clin Mol Teratol. 2016 12; 106(12):1062. PMID: 28000437.
      View in: PubMed
    44. McCollum CW, Conde-Vancells J, Hans C, Vazquez-Chantada M, Kleinstreuer N, Tal T, Knudsen T, Shah SS, Merchant FA, Finnell RH, Gustafsson JÅ, Cabrera R, Bondesson M. Identification of vascular disruptor compounds by analysis in zebrafish embryos and mouse embryonic endothelial cells. Reprod Toxicol. 2017 06; 70:60-69. PMID: 27838387.
      View in: PubMed
    45. Qiao X, Liu Y, Li P, Chen Z, Li H, Yang X, Finnell RH, Yang Z, Zhang T, Qiao B, Zheng Y, Wang H. Genetic analysis of rare coding mutations of CELSR1-3 in congenital heart and neural tube defects in Chinese people. Clin Sci (Lond). 2016 Dec 01; 130(24):2329-2340. PMID: 27756857.
      View in: PubMed
    46. Brzóska HL, d'Esposito AM, Kolatsi-Joannou M, Patel V, Igarashi P, Lei Y, Finnell RH, Lythgoe MF, Woolf AS, Papakrivopoulou E, Long DA. Planar cell polarity genes Celsr1 and Vangl2 are necessary for kidney growth, differentiation, and rostrocaudal patterning. Kidney Int. 2016 12; 90(6):1274-1284. PMID: 27597235.
      View in: PubMed
    47. Finnell RH, Shaw GM. Remembering Edward J. Lammer, MD. Am J Med Genet A. 2016 Nov; 170(11):2767-2768. PMID: 27481654.
      View in: PubMed
    48. Yang N, Wang L, Finnell RH, Li Z, Jin L, Zhang L, Cabrera RM, Ye R, Ren A. Levels of folate receptor autoantibodies in maternal and cord blood and risk of neural tube defects in a Chinese population. Birth Defects Res A Clin Mol Teratol. 2016 Aug; 106(8):685-95. PMID: 27166990.
      View in: PubMed
    49. Denny KJ, Kelly CF, Kumar V, Witham KL, Cabrera RM, Finnell RH, Taylor SM, Jeanes A, Woodruff TM. Autoantibodies against homocysteinylated protein in a mouse model of folate deficiency-induced neural tube defects. Birth Defects Res A Clin Mol Teratol. 2016 Mar; 106(3):201-7. PMID: 26900104.
      View in: PubMed
    50. Lei Y, Finnell RH. New Techniques for the Study of Neural Tube Defects. Adv Tech Biol Med. 2016 Feb; 4(1). PMID: 27066597.
      View in: PubMed
    51. Hill DS, Cabrera R, Wallis Schultz D, Zhu H, Lu W, Finnell RH, Wlodarczyk BJ. Autism-Like Behavior and Epigenetic Changes Associated with Autism as Consequences of In Utero Exposure to Environmental Pollutants in a Mouse Model. Behav Neurol. 2015; 2015:426263. PMID: 26586927.
      View in: PubMed
    52. Wlodarczyk BJ, Ogle K, Lin LY, Bialer M, Finnell RH. Comparative teratogenicity analysis of valnoctamide, risperidone, and olanzapine in mice. Bipolar Disord. 2015 Sep; 17(6):615-25. PMID: 26292082.
      View in: PubMed
    53. Shawlot W, Vazquez-Chantada M, Wallingford JB, Finnell RH. Rfx2 is required for spermatogenesis in the mouse. Genesis. 2015 Sep; 53(9):604-611. PMID: 26248850.
      View in: PubMed
    54. Wang B, Jin L, Ren A, Yuan Y, Liu J, Li Z, Zhang L, Yi D, Wang LL, Zhang Y, Wang X, Tao S, Finnell RH. Correction to Levels of Polycyclic Aromatic Hydrocarbons in Maternal Serum and Risk of Neural Tube Defects in Offspring. Environ Sci Technol. 2015 Sep 01; 49(17):10754-5. PMID: 26274604.
      View in: PubMed
    55. Cantarel BL, Lei Y, Weaver D, Zhu H, Farrell A, Benstead-Hume G, Reese J, Finnell RH. Analysis of archived residual newborn screening blood spots after whole genome amplification. BMC Genomics. 2015 Aug 13; 16:602. PMID: 26268606.
      View in: PubMed
    56. Webber DM, MacLeod SL, Bamshad MJ, Shaw GM, Finnell RH, Shete SS, Witte JS, Erickson SW, Murphy LD, Hobbs C. Developments in our understanding of the genetic basis of birth defects. Birth Defects Res A Clin Mol Teratol. 2015 Aug; 103(8):680-91. PMID: 26033863.
      View in: PubMed
    57. Mawasi H, Shekh-Ahmad T, Finnell RH, Wlodarczyk BJ, Bialer M. Pharmacodynamic and pharmacokinetic analysis of CNS-active constitutional isomers of valnoctamide and sec-butylpropylacetamide--Amide derivatives of valproic acid. Epilepsy Behav. 2015 May; 46:72-8. PMID: 25863940.
      View in: PubMed
    58. Lei Y, Fathe K, McCartney D, Zhu H, Yang W, Ross ME, Shaw GM, Finnell RH. Rare LRP6 variants identified in spina bifida patients. Hum Mutat. 2015 Mar; 36(3):342-9. PMID: 25546815.
      View in: PubMed
    59. Wang B, Jin L, Ren A, Yuan Y, Liu J, Li Z, Zhang L, Yi D, Wang LL, Zhang Y, Wang X, Tao S, Finnell RH. Levels of polycyclic aromatic hydrocarbons in maternal serum and risk of neural tube defects in offspring. Environ Sci Technol. 2015 Jan 06; 49(1):588-96. PMID: 25488567.
      View in: PubMed
    60. Yi D, Yuan Y, Jin L, Zhou G, Zhu H, Finnell RH, Ren A. Levels of PAH-DNA adducts in cord blood and cord tissue and the risk of fetal neural tube defects in a Chinese population. Neurotoxicology. 2015 Jan; 46:73-8. PMID: 25522656.
      View in: PubMed
    61. Shekh-Ahmad T, Mawasi H, McDonough JH, Finnell RH, Wlodarczyk BJ, Yavin E, Bialer M. Enantioselective pharmacodynamic and pharmacokinetic analysis of two chiral CNS-active carbamate derivatives of valproic acid. Epilepsia. 2014 Dec; 55(12):1944-52. PMID: 25442425.
      View in: PubMed
    62. Fathe K, Person MD, Finnell RH. The application of a chemical determination of N-homocysteinylation levels in developing mouse embryos: implication for folate responsive birth defects. J Nutr Biochem. 2015 Apr; 26(4):312-8. PMID: 25620692.
      View in: PubMed
    63. Martínez-Uña M, Varela-Rey M, Mestre D, Fernández-Ares L, Fresnedo O, Fernandez-Ramos D, Gutiérrez-de Juan V, Martin-Guerrero I, García-Orad A, Luka Z, Wagner C, Lu SC, García-Monzón C, Finnell RH, Aurrekoetxea I, Buqué X, Martínez-Chantar ML, Mato JM, Aspichueta P. S-Adenosylmethionine increases circulating very-low density lipoprotein clearance in non-alcoholic fatty liver disease. J Hepatol. 2015 Mar; 62(3):673-81. PMID: 25457203.
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    64. Hansler A, Chen Q, Gray JD, Ross ME, Finnell RH, Gross SS. Untargeted metabolite profiling of murine embryos to reveal metabolic perturbations associated with neural tube closure defects. Birth Defects Res A Clin Mol Teratol. 2014 Aug; 100(8):623-32. PMID: 25115437.
      View in: PubMed
    65. Mitchell LE, Finnell RH. Papers from the Eighth International Neural Tube Defects Conference. Birth Defects Res A Clin Mol Teratol. 2014 Aug; 100(8):561-2. PMID: 25155952.
      View in: PubMed
    66. Fathe K, Palacios A, Finnell RH. Brief report novel mechanism for valproate-induced teratogenicity. Birth Defects Res A Clin Mol Teratol. 2014 Aug; 100(8):592-7. PMID: 25066307.
      View in: PubMed
    67. Tsurubuchi T, Allender EV, Siddiqui MR, Shim KW, Ichi S, Boshnjaku V, Mania-Farnell B, Xi G, Finnell RH, McLone DG, Tomita T, Mayanil CS. A critical role of noggin in developing folate-nonresponsive NTD in Fkbp8 -/- embryos. Childs Nerv Syst. 2014 Aug; 30(8):1343-53. PMID: 24817375.
      View in: PubMed
    68. Lei Y, Zhu H, Yang W, Ross ME, Shaw GM, Finnell RH. Identification of novel CELSR1 mutations in spina bifida. PLoS One. 2014; 9(3):e92207. PMID: 24632739.
      View in: PubMed
    69. Wlodarczyk BJ, Zhu H, Finnell RH. Mthfr gene ablation enhances susceptibility to arsenic prenatal toxicity. Toxicol Appl Pharmacol. 2014 Feb 15; 275(1):22-7. PMID: 24384392.
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    247. Finnell RH, Shaw GM, Lammer EJ, Volcik KA. Does prenatal screening for 5,10-methylenetetrahydrofolate reductase (MTHFR) mutations in high-risk neural tube defect pregnancies make sense? Genet Test. 2002; 6(1):47-52. PMID: 12180076.
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    248. Wlodarczyk B, Spiegelstein O, Gelineau-van Waes J, Vorce RL, Lu X, Le CX, Finnell RH. Arsenic-induced congenital malformations in genetically susceptible folate binding protein-2 knockout mice. Toxicol Appl Pharmacol. 2001 Dec 15; 177(3):238-46. PMID: 11749123.
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    250. Waes JG, Finnell RH. Importance of model organisms in understanding the biology and genetic basis of human nonsyndromic neural tube defects. Teratology. 2001 Oct; 64(4):177-80. PMID: 11598923.
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    251. Gelineau-van Waes J, Finnell RH. Genetics of neural tube defects. Semin Pediatr Neurol. 2001 Sep; 8(3):160-4. PMID: 11575845.
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    252. Stegmann K, Boecker J, Richter B, Capra V, Finnell RH, Ngo ET, Strehl E, Ermert A, Koch MC. A screen for mutations in human homologues of mice exencephaly genes Tfap2alpha and Msx2 in patients with neural tube defects. Teratology. 2001 May; 63(5):167-75. PMID: 11320527.
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    253. Rosenquist TH, Finnell RH. Genes, folate and homocysteine in embryonic development. Proc Nutr Soc. 2001 Feb; 60(1):53-61. PMID: 11310424.
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    254. Eudy JD, Spiegelstein O, Barber RC, Wlodarczyk BJ, Talbot J, Finnell RH. Identification and characterization of the human and mouse SLC19A3 gene: a novel member of the reduced folate family of micronutrient transporter genes. Mol Genet Metab. 2000 Dec; 71(4):581-90. PMID: 11136550.
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    255. De Marco P, Moroni A, Merello E, de Franchis R, Andreussi L, Finnell RH, Barber RC, Cama A, Capra V. Folate pathway gene alterations in patients with neural tube defects. Am J Med Genet. 2000 Nov 27; 95(3):216-23. PMID: 11102926.
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    256. Spiegelstein O, Eudy JD, Finnell RH. Identification of two putative novel folate receptor genes in humans and mouse. Gene. 2000 Nov 27; 258(1-2):117-25. PMID: 11111049.
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    257. Ruan Y, Peterson MH, Wauson EM, Waes JG, Finnell RH, Vorce RL. Folic acid protects SWV/Fnn embryo fibroblasts against arsenic toxicity. Toxicol Lett. 2000 Nov 20; 117(3):129-37. PMID: 11087978.
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    258. Finnell RH, Burn J. Effect of anti-epileptic drugs on intrauterine growth. Lancet. 2000 Nov 04; 356(9241):1537-8. PMID: 11075761.
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    259. Spiegelstein O, Yagen B, Bennett GD, Finnell RH, Blotnik S, Bialer M. Stereoselective pharmacokinetic analysis of valnoctamide, a CNS-active chiral amide analogue of valproic acid, in dogs, rats, and mice. Ther Drug Monit. 2000 Oct; 22(5):574-81. PMID: 11034263.
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    260. Shaw GM, Todoroff K, Finnell RH, Lammer EJ. Spina bifida phenotypes in infants or fetuses of obese mothers. Teratology. 2000 May; 61(5):376-81. PMID: 10777833.
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    261. Craig JC, Bennett GD, Miranda RC, Mackler SA, Finnell RH. Ribonucleotide reductase subunit R1: a gene conferring sensitivity to valproic acid-induced neural tube defects in mice. Teratology. 2000 Apr; 61(4):305-13. PMID: 10716750.
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    262. Shaw GM, Barber R, Todoroff K, Lammer EJ, Finnell RH. Microsatellites proximal to leptin and leptin receptor as risk factors for spina bifida. Teratology. 2000 Mar; 61(3):231-5. PMID: 10661913.
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    263. Finnell RH, Gelineau-van Waes J, Bennett GD, Barber RC, Wlodarczyk B, Shaw GM, Lammer EJ, Piedrahita JA, Eberwine JH. Genetic basis of susceptibility to environmentally induced neural tube defects. Ann N Y Acad Sci. 2000; 919:261-77. PMID: 11083116.
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    265. Spiegelstein O, Yagen B, Levy RH, Finnell RH, Bennett GD, Roeder M, Schurig V, Bialer M. Stereoselective pharmacokinetics and pharmacodynamics of propylisopropyl acetamide, a CNS-active chiral amide analog of valproic acid. Pharm Res. 1999 Oct; 16(10):1582-8. PMID: 10554101.
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    266. Piedrahita JA, Oetama B, Bennett GD, van Waes J, Kamen BA, Richardson J, Lacey SW, Anderson RG, Finnell RH. Mice lacking the folic acid-binding protein Folbp1 are defective in early embryonic development. Nat Genet. 1999 Oct; 23(2):228-32. PMID: 10508523.
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    267. Rao VH, Singh RK, Delimont DC, Schaefer GB, Bridge JA, Neff JR, Sanger WG, Sappenfield JW, Buehler BA, Finnell RH. Interleukin-1beta upregulates MMP-9 expression in stromal cells of human giant cell tumor of bone. J Interferon Cytokine Res. 1999 Oct; 19(10):1207-17. PMID: 10547161.
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    268. McAlhany RE, Miranda RC, Finnell RH, West JR. Ethanol decreases Glial-Derived Neurotrophic Factor (GDNF) protein release but not mRNA expression and increases GDNF-stimulated Shc phosphorylation in the developing cerebellum. Alcohol Clin Exp Res. 1999 Oct; 23(10):1691-7. PMID: 10550003.
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    269. Shaw GM, Todoroff K, Finnell RH, Rozen R, Lammer EJ. Maternal vitamin use, infant C677T mutation in MTHFR, and isolated cleft palate risk. Am J Med Genet. 1999 Jul 02; 85(1):84-5. PMID: 10377018.
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    270. Trembath D, Sherbondy AL, Vandyke DC, Shaw GM, Todoroff K, Lammer EJ, Finnell RH, Marker S, Lerner G, Murray JC. Analysis of select folate pathway genes, PAX3, and human T in a Midwestern neural tube defect population. Teratology. 1999 May; 59(5):331-41. PMID: 10332959.
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    271. Finnell RH, Bennett GD, Mather GG, Wlodarczyk B, Bajpai M, Levy RH. Effect of stiripentol dose on phenytoin-induced teratogenesis in a mouse model. Reprod Toxicol. 1999 Mar-Apr; 13(2):85-91. PMID: 10213515.
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    272. Finnell RH. Teratology: general considerations and principles. J Allergy Clin Immunol. 1999 Feb; 103(2 Pt 2):S337-42. PMID: 9949334.
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    273. Rao VH, Singh RK, Delimont DC, Finnell RH, Bridge JA, Neff JR, Garvin BP, Pickering DL, Sanger WG, Buehler BA, Schaefer GB. Transcriptional regulation of MMP-9 expression in stromal cells of human giant cell tumor of bone by tumor necrosis factor-alpha. Int J Oncol. 1999 Feb; 14(2):291-300. PMID: 9917505.
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    274. Barber RC, Lammer EJ, Shaw GM, Greer KA, Finnell RH. The role of folate transport and metabolism in neural tube defect risk. Mol Genet Metab. 1999 Jan; 66(1):1-9. PMID: 9973541.
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    275. Koebbe MJ, Golden JA, Bennett G, Finnell RH, Mackler SA. Effects of prenatal cocaine exposure on embryonic expression of sonic hedgehog. Teratology. 1999 Jan; 59(1):12-9. PMID: 9988878.
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    276. Shaw GM, Todoroff K, Finnell RH, Lammer EJ, Leclerc D, Gravel RA, Rozen R. Infant methionine synthase variants and risk for spina bifida. J Med Genet. 1999 Jan; 36(1):86-7. PMID: 9950377.
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    277. Barber RC, Bennett GD, Greer KA, Finnell RH. Expression patterns of folate binding proteins one and two in the developing mouse embryo. Mol Genet Metab. 1999 Jan; 66(1):31-9. PMID: 9973545.
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    278. Gelineau-van Waes J, Bennett GD, Finnell RH. Phenytoin-induced alterations in craniofacial gene expression. Teratology. 1999 Jan; 59(1):23-34. PMID: 9988880.
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    279. Shaw GM, Rozen R, Finnell RH, Todoroff K, Lammer EJ. Infant C677T mutation in MTHFR, maternal periconceptional vitamin use, and cleft lip. Am J Med Genet. 1998 Nov 16; 80(3):196-8. PMID: 9843036.
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    280. Hefer T, Joachims HZ, Carlson D, Finnell RH. [Factors associated with the etiology of congenital craniofacial anomalies--Part II]. Harefuah. 1998 Oct; 135(7-8):286-91. PMID: 9885676.
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    281. Hefer T, Joachims HZ, Carlson D, Finnell RH. [Factors associated with the etiology of congenital craniofacial anomalies--Part I]. Harefuah. 1998 Sep; 135(5-6):209-13. PMID: 9885638.
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    282. Shaw GM, Rozen R, Finnell RH, Wasserman CR, Lammer EJ. Maternal vitamin use, genetic variation of infant methylenetetrahydrofolate reductase, and risk for spina bifida. Am J Epidemiol. 1998 Jul 01; 148(1):30-7. PMID: 9663401.
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    283. Barber RC, Shaw GM, Lammer EJ, Greer KA, Biela TA, Lacey SW, Wasserman CR, Finnell RH. Lack of association between mutations in the folate receptor-alpha gene and spina bifida. Am J Med Genet. 1998 Apr 01; 76(4):310-7. PMID: 9545095.
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    284. Bennett GD, An J, Craig JC, Gefrides LA, Calvin JA, Finnell RH. Neurulation abnormalities secondary to altered gene expression in neural tube defect susceptible Splotch embryos. Teratology. 1998 Jan; 57(1):17-29. PMID: 9516748.
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    286. Amore BM, Kalhorn TF, Skiles GL, Hunter AP, Bennett GD, Finnell RH, Nelson SD, Slattery JT. Characterization of carbamazepine metabolism in a mouse model of carbamazepine teratogenicity. Drug Metab Dispos. 1997 Aug; 25(8):953-62. PMID: 9280403.
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    287. Finnell RH, Wlodarczyk BC, Craig JC, Piedrahita JA, Bennett GD. Strain-dependent alterations in the expression of folate pathway genes following teratogenic exposure to valproic acid in a mouse model. Am J Med Genet. 1997 Jun 13; 70(3):303-11. PMID: 9188671.
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    288. Craig JC, Eberwine JH, Calvin JA, Wlodarczyk B, Bennett GD, Finnell RH. Developmental expression of morphoregulatory genes in the mouse embryo: an analytical approach using a novel technology. Biochem Mol Med. 1997 Apr; 60(2):81-91. PMID: 9169087.
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    290. Vacha SJ, Bennett GD, Mackler SA, Koebbe MJ, Finnell RH. Identification of a growth arrest specific (gas 5) gene by differential display as a candidate gene for determining susceptibility to hyperthermia-induced exencephaly in mice. Dev Genet. 1997; 21(3):212-22. PMID: 9397537.
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    292. Bennett GD, Amore BM, Finnell RH, Wlodarczyk B, Kalhorn TF, Skiles GL, Nelson SD, Slattery JT. Teratogenicity of carbamazepine-10, 11-epoxide and oxcarbazepine in the SWV mouse. J Pharmacol Exp Ther. 1996 Dec; 279(3):1237-42. PMID: 8968346.
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    293. Wlodarczyk BJ, Bennett GD, Calvin JA, Finnell RH. Arsenic-induced neural tube defects in mice: alterations in cell cycle gene expression. Reprod Toxicol. 1996 Nov-Dec; 10(6):447-54. PMID: 8946558.
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    294. Shalat SL, Walker DB, Finnell RH. Role of arsenic as a reproductive toxin with particular attention to neural tube defects. J Toxicol Environ Health. 1996 Jun 28; 48(3):253-72. PMID: 8656449.
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    295. Lillibridge JH, Amore BM, Slattery JT, Kalhorn TF, Nelson SD, Finnell RH, Bennett GD. Protein-reactive metabolites of carbamazepine in mouse liver microsomes. Drug Metab Dispos. 1996 May; 24(5):509-14. PMID: 8723729.
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    296. Wlodraczyk B, Bennett GD, Calvin JA, Craig JC, Finnell RH. Arsenic-induced alterations in embryonic transcription factor gene expression: implications for abnormal neural development. Dev Genet. 1996; 18(4):306-15. PMID: 8754282.
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    297. Mackler SA, Bennett GD, Tsuei VP, Finnell RH. Cocaine selectively alters neurotransmitter receptor mRNAs in mouse embryos. Reprod Toxicol. 1996 Jan-Feb; 10(1):37-42. PMID: 8998384.
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    298. Finnell RH, Bennett GD, Slattery JT, Amore BM, Bajpai M, Levy RH. Effect of treatment with phenobarbital and stiripentol on carbamazepine-induced teratogenicity and reactive metabolite formation. Teratology. 1995 Dec; 52(6):324-32. PMID: 8711619.
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    299. Raymond GV, Buehler BA, Finnell RH, Holmes LB. Anticonvulsant teratogenesis: 3. Possible metabolic basis. Teratology. 1995 Feb; 51(2):55-6. PMID: 7660321.
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    300. Taylor LE, Bennett GD, Finnell RH. Altered gene expression in murine branchial arches following in utero exposure to retinoic acid. J Craniofac Genet Dev Biol. 1995 Jan-Mar; 15(1):13-25. PMID: 7601910.
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    301. Shaw GM, Wasserman CR, O'Malley CD, Lammer EJ, Finnell RH. Orofacial clefts and maternal anticonvulsant use. Reprod Toxicol. 1995 Jan-Feb; 9(1):97-8. PMID: 8520135.
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    302. Buehler BA, Rao V, Finnell RH. Biochemical and molecular teratology of fetal hydantoin syndrome. Neurol Clin. 1994 Nov; 12(4):741-8. PMID: 7845340.
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    303. Musselman AC, Bennett GD, Greer KA, Eberwine JH, Finnell RH. Preliminary evidence of phenytoin-induced alterations in embryonic gene expression in a mouse model. Reprod Toxicol. 1994 Sep-Oct; 8(5):383-95. PMID: 7841657.
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    304. Finnell RH, Kerr BM, van Waes M, Steward RL, Levy RH. Protection from phenytoin-induced congenital malformations by coadministration of the antiepileptic drug stiripentol in a mouse model. Epilepsia. 1994 Jan-Feb; 35(1):141-8. PMID: 8112237.
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    306. Finnell RH, Van Waes M, Bennett GD, Eberwine JH. Lack of concordance between heat shock proteins and the development of tolerance to teratogen-induced neural tube defects. Dev Genet. 1993; 14(2):137-47. PMID: 8482018.
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    309. Finnell RH, Mohl VK, Englen MD. In vitro analysis of the murine heat shock response: implications for reproductive toxicology. Toxicol Lett. 1991 Nov; 58(3):297-308. PMID: 1957325.
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    313. Dansky LV, Finnell RH. Parental epilepsy, anticonvulsant drugs, and reproductive outcome: epidemiologic and experimental findings spanning three decades; 2: Human studies. Reprod Toxicol. 1991; 5(4):301-35. PMID: 1806139.
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    314. Buehler BA, Delimont D, van Waes M, Finnell RH. Prenatal prediction of risk of the fetal hydantoin syndrome. N Engl J Med. 1990 May 31; 322(22):1567-72. PMID: 2336087.
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    315. Finnell RH, Toloyan S, van Waes M, Kalivas PW. Preliminary evidence for a cocaine-induced embryopathy in mice. Toxicol Appl Pharmacol. 1990 Apr; 103(2):228-37. PMID: 2330587.
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    316. Mohl VK, Bennett GD, Finnell RH. Genetic differences in the duration of the lymphocyte heat shock response in mice. Genetics. 1990 Apr; 124(4):949-55. PMID: 2323557.
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    318. Finnell RH, Abbott LC, Taylor SM. The fetal hydantoin syndrome: answers from a mouse model. Reprod Toxicol. 1989; 3(2):127-33. PMID: 2520510.
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    319. Finnell RH, Bennett GD, Karras SB, Mohl VK. Common hierarchies of susceptibility to the induction of neural tube defects in mouse embryos by valproic acid and its 4-propyl-4-pentenoic acid metabolite. Teratology. 1988 Oct; 38(4):313-20. PMID: 3149038.
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    320. Finnell RH, Chernoff GF. Anagyrine-induced congenital defects. J Pediatr. 1988 Feb; 112(2):331. PMID: 3339518.
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    321. Finnell RH, Shields HE, Taylor SM, Chernoff GF. Strain differences in phenobarbital-induced teratogenesis in mice. Teratology. 1987 Apr; 35(2):177-85. PMID: 3603402.
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    322. Boehnke WH, Chernoff GF, Finnell RH. Investigation of the teratogenic effects of exercise on pregnancy outcome in mice. Teratog Carcinog Mutagen. 1987; 7(4):391-7. PMID: 2888217.
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    323. Taylor SM, Finnell RH. Effect of quinidine and tetrodotoxin on the activation of non-adrenergic nerves in guinea-pig trachealis muscle. Comp Biochem Physiol C. 1987; 86(1):11-5. PMID: 2881704.
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    324. Finnell RH, Shields HE, Chernoff GF. Variable patterns in anticonvulsant drug-induced malformations in mice: comparisons of phenytoin and phenobarbital. Teratog Carcinog Mutagen. 1987; 7(6):541-9. PMID: 2893467.
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    325. Abbott LC, Finnell RH, Chernoff GF, Parish SM, Gay CC. Crooked calf disease: a histological and histochemical examination of eight affected calves. Vet Pathol. 1986 Nov; 23(6):734-40. PMID: 3811138.
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    326. Finnell RH, Baer JF. Congenital defects among the offspring of epileptic fathers: role of the genotype and phenytoin therapy in a mouse model. Epilepsia. 1986 Nov-Dec; 27(6):697-705. PMID: 3780606.
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    327. Willow M, Taylor SM, Catterall WA, Finnell RH. Down regulation of sodium channels in nerve terminals of spontaneously epileptic mice. Cell Mol Neurobiol. 1986 Jun; 6(2):213-20. PMID: 2425971.
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    328. Finnell RH, Moon SP, Abbott LC, Golden JA, Chernoff GF. Strain differences in heat-induced neural tube defects in mice. Teratology. 1986 Apr; 33(2):247-52. PMID: 3738820.
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    329. Finnell RH, Mohl VK, Bennett GD, Taylor SM. Failure of epoxide formation to influence carbamazepine-induced teratogenesis in a mouse model. Teratog Carcinog Mutagen. 1986; 6(5):393-401. PMID: 2878505.
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    330. Taylor SM, Bennett GD, Abbott LC, Finnell RH. Seizure control following administration of anticonvulsant drugs in the quaking mouse. Eur J Pharmacol. 1985 Nov 26; 118(1-2):163-70. PMID: 3936724.
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    331. Finnell RH, Chernoff GF. Genetic background: the elusive component in the fetal hydantoin syndrome. Am J Med Genet. 1984 Nov; 19(3):459-62. PMID: 6507492.
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    332. Finnell RH, Chernoff GF. Variable patterns of malformation in the mouse fetal hydantoin syndrome. Am J Med Genet. 1984 Nov; 19(3):463-71. PMID: 6507493.
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    333. Finnell RH, Chernoff GF. Mouse fetal hydantoin syndrome: effects of maternal seizures. Epilepsia. 1982 Aug; 23(4):423-9. PMID: 7094908.
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