RENAN ORELLANA

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address6621 FANNIN
Houston, TX 77030
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    Collapse Biography 
    Collapse awards and honors
    2012Vernon R. Young International Award for Amino Acid Research, American Society for Nutrition
    2011Samuel J. Fomon Young Physician Award, american Society for Nutrition

    Collapse Research 
    Collapse research activities and funding
    K08AR051563     (ORELLANA, RENAN A)May 1, 2005 - Apr 30, 2011
    NIH
    Regulation of Protein Synthesis in Neonatal Sepsis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Yock-Corrales A, Casson N, Sosa-Soto G, Orellana RA. Pediatric Critical Care Transport: Survey of Current State in Latin America. Latin American Society of Pediatric Intensive Care Transport Committee. Pediatr Emerg Care. 2022 Jan 01; 38(1):e295-e299. PMID: 33105465.
      Citations:    Fields:    Translation:Humans
    2. Navaei AH, Shekerdemian LS, Mohammad MA, Coss-Bu JA, Bastero P, Ettinger NA, Orellana R, Fernandes CJ, Marini JC. Derangement of Arginine and Related Amino Acids in Children Undergoing Surgery for Congenital Heart Disease With Cardiopulmonary Bypass. Crit Care Explor. 2020 Jul; 2(7):e0150. PMID: 32766551.
      Citations: 2     
    3. Branco RG, Orellana RA. Physician Awareness and Management Practices of Fluid Overload in Critically Ill Children. Pediatr Crit Care Med. 2018 10; 19(10):1012-1014. PMID: 30281576.
      Citations:    Fields:    Translation:Humans
    4. El-Kadi SW, Boutry C, Suryawan A, Gazzaneo MC, Orellana RA, Srivastava N, Nguyen HV, Kimball SR, Fiorotto ML, Davis TA. Intermittent bolus feeding promotes greater lean growth than continuous feeding in a neonatal piglet model. Am J Clin Nutr. 2018 10 01; 108(4):830-841. PMID: 30239549.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    5. Hernandez-García AD, Columbus DA, Manjarín R, Nguyen HV, Suryawan A, Orellana RA, Davis TA. Leucine supplementation stimulates protein synthesis and reduces degradation signal activation in muscle of newborn pigs during acute endotoxemia. Am J Physiol Endocrinol Metab. 2016 10 01; 311(4):E791-E801. PMID: 27624100.
      Citations: 9     Fields:    Translation:AnimalsCells
    6. Manjarín R, Suryawan A, Koo SJ, Wilson FA, Nguyen HV, Davis TA, Orellana RA. Insulin modulates energy and substrate sensing and protein catabolism induced by chronic peritonitis in skeletal muscle of neonatal pigs. Pediatr Res. 2016 11; 80(5):744-752. PMID: 27508897.
      Citations: 2     Fields:    Translation:AnimalsCells
    7. Kyle UG, Lucas LA, Mackey G, Silva JC, Lusk J, Orellana R, Shekerdemian LS, Coss-Bu JA. Implementation of Nutrition Support Guidelines May Affect Energy and Protein Intake in the Pediatric Intensive Care Unit. J Acad Nutr Diet. 2016 05; 116(5):844-851.e4. PMID: 27126156.
      Citations: 2     Fields:    Translation:Humans
    8. Hernandez-García A, Manjarín R, Suryawan A, Nguyen HV, Davis TA, Orellana RA. Amino acids, independent of insulin, attenuate skeletal muscle autophagy in neonatal pigs during endotoxemia. Pediatr Res. 2016 09; 80(3):448-51. PMID: 27064245.
      Citations: 4     Fields:    Translation:Animals
    9. Boutry C, El-Kadi SW, Suryawan A, Steinhoff-Wagner J, Stoll B, Orellana RA, Nguyen HV, Kimball SR, Fiorotto ML, Davis TA. Pulsatile delivery of a leucine supplement during long-term continuous enteral feeding enhances lean growth in term neonatal pigs. Am J Physiol Endocrinol Metab. 2016 04 15; 310(8):E699-E713. PMID: 26884386.
      Citations: 2     Fields:    Translation:AnimalsCells
    10. Wheatley SM, El-Kadi SW, Suryawan A, Boutry C, Orellana RA, Nguyen HV, Davis SR, Davis TA. Protein synthesis in skeletal muscle of neonatal pigs is enhanced by administration of ß-hydroxy-ß-methylbutyrate. Am J Physiol Endocrinol Metab. 2014 Jan 01; 306(1):E91-9. PMID: 24192287.
      Citations: 14     Fields:    Translation:AnimalsCells
    11. Kyle UG, Spoede ET, Mallory GB, Orellana R, Shekerdemian LS, Schecter MG, Coss-Bu JA. Changes in body composition after lung transplantation in children. J Heart Lung Transplant. 2013 Aug; 32(8):800-6. PMID: 23856217.
      Citations: 3     Fields:    Translation:Humans
    12. Boutry C, El-Kadi SW, Suryawan A, Wheatley SM, Orellana RA, Kimball SR, Nguyen HV, Davis TA. Leucine pulses enhance skeletal muscle protein synthesis during continuous feeding in neonatal pigs. Am J Physiol Endocrinol Metab. 2013 Sep 01; 305(5):E620-31. PMID: 23839523.
      Citations: 21     Fields:    Translation:Animals
    13. El-Kadi SW, Gazzaneo MC, Suryawan A, Orellana RA, Torrazza RM, Srivastava N, Kimball SR, Nguyen HV, Fiorotto ML, Davis TA. Viscera and muscle protein synthesis in neonatal pigs is increased more by intermittent bolus than by continuous feeding. Pediatr Res. 2013 Aug; 74(2):154-62. PMID: 23736770.
      Citations: 7     Fields:    Translation:AnimalsCells
    14. Toole BJ, Toole LE, Kyle UG, Cabrera AG, Orellana RA, Coss-Bu JA. Perioperative nutritional support and malnutrition in infants and children with congenital heart disease. Congenit Heart Dis. 2014 Jan-Feb; 9(1):15-25. PMID: 23602045.
      Citations: 12     Fields:    Translation:Humans
    15. Kyle UG, Akcan-Arikan A, Orellana RA, Coss-Bu JA. Nutrition support among critically ill children with AKI. Clin J Am Soc Nephrol. 2013 Apr; 8(4):568-74. PMID: 23293125.
      Citations: 4     Fields:    Translation:Humans
    16. Suryawan A, Torrazza RM, Gazzaneo MC, Orellana RA, Fiorotto ML, El-Kadi SW, Srivastava N, Nguyen HV, Davis TA. Enteral leucine supplementation increases protein synthesis in skeletal and cardiac muscles and visceral tissues of neonatal pigs through mTORC1-dependent pathways. Pediatr Res. 2012 Apr; 71(4 Pt 1):324-31. PMID: 22391631.
      Citations: 25     Fields:    Translation:AnimalsCells
    17. Orellana RA, Suryawan A, Wilson FA, Gazzaneo MC, Fiorotto ML, Nguyen HV, Davis TA. Development aggravates the severity of skeletal muscle catabolism induced by endotoxemia in neonatal pigs. Am J Physiol Regul Integr Comp Physiol. 2012 Mar 15; 302(6):R682-90. PMID: 22277935.
      Citations: 12     Fields:    Translation:Animals
    18. El-Kadi SW, Suryawan A, Gazzaneo MC, Srivastava N, Orellana RA, Nguyen HV, Lobley GE, Davis TA. Anabolic signaling and protein deposition are enhanced by intermittent compared with continuous feeding in skeletal muscle of neonates. Am J Physiol Endocrinol Metab. 2012 Mar 15; 302(6):E674-86. PMID: 22215651.
      Citations: 17     Fields:    Translation:AnimalsCells
    19. Gazzaneo MC, Suryawan A, Orellana RA, Torrazza RM, El-Kadi SW, Wilson FA, Kimball SR, Srivastava N, Nguyen HV, Fiorotto ML, Davis TA. Intermittent bolus feeding has a greater stimulatory effect on protein synthesis in skeletal muscle than continuous feeding in neonatal pigs. J Nutr. 2011 Dec; 141(12):2152-8. PMID: 22013195.
      Citations: 23     Fields:    Translation:AnimalsCells
    20. Gazzaneo MC, Orellana RA, Suryawan A, Tuckow AP, Kimball SR, Wilson FA, Nguyen HV, Torrazza RM, Fiorotto ML, Davis TA. Differential regulation of protein synthesis and mTOR signaling in skeletal muscle and visceral tissues of neonatal pigs after a meal. Pediatr Res. 2011 Sep; 70(3):253-60. PMID: 21654549.
      Citations: 14     Fields:    Translation:AnimalsCells
    21. Orellana RA, Wilson FA, Gazzaneo MC, Suryawan A, Davis TA, Nguyen HV. Sepsis and development impede muscle protein synthesis in neonatal pigs by different ribosomal mechanisms. Pediatr Res. 2011 Jun; 69(6):473-8. PMID: 21364490.
      Citations: 6     Fields:    Translation:AnimalsCells
    22. Murgas Torrazza R, Suryawan A, Gazzaneo MC, Orellana RA, Frank JW, Nguyen HV, Fiorotto ML, El-Kadi S, Davis TA. Leucine supplementation of a low-protein meal increases skeletal muscle and visceral tissue protein synthesis in neonatal pigs by stimulating mTOR-dependent translation initiation. J Nutr. 2010 Dec; 140(12):2145-52. PMID: 20962152.
      Citations: 32     Fields:    Translation:AnimalsCells
    23. Suryawan A, Orellana RA, Fiorotto ML, Davis TA. Triennial Growth Symposium: leucine acts as a nutrient signal to stimulate protein synthesis in neonatal pigs. J Anim Sci. 2011 Jul; 89(7):2004-16. PMID: 20935141.
      Citations: 14     Fields:    Translation:Animals
    24. Wilson FA, Suryawan A, Orellana RA, Gazzaneo MC, Nguyen HV, Davis TA. Differential effects of long-term leucine infusion on tissue protein synthesis in neonatal pigs. Amino Acids. 2011 Jan; 40(1):157-65. PMID: 20505962.
      Citations: 11     Fields:    Translation:AnimalsCells
    25. Davis TA, Suryawan A, Orellana RA, Fiorotto ML, Burrin DG. Amino acids and insulin are regulators of muscle protein synthesis in neonatal pigs. Animal. 2010; 4(11):1790-1796. PMID: 21779306.
      Citations: 6     Fields:    
    26. Wilson FA, Suryawan A, Gazzaneo MC, Orellana RA, Nguyen HV, Davis TA. Stimulation of muscle protein synthesis by prolonged parenteral infusion of leucine is dependent on amino acid availability in neonatal pigs. J Nutr. 2010 Feb; 140(2):264-70. PMID: 20032489.
      Citations: 32     Fields:    Translation:AnimalsCells
    27. Wilson FA, Suryawan A, Orellana RA, Kimball SR, Gazzaneo MC, Nguyen HV, Fiorotto ML, Davis TA. Feeding rapidly stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing translation initiation. J Nutr. 2009 Oct; 139(10):1873-80. PMID: 19692527.
      Citations: 18     Fields:    Translation:AnimalsCells
    28. Orellana RA, Suryawan A, Kimball SR, Wu G, Nguyen HV, Jefferson LS, Davis TA. Insulin signaling in skeletal muscle and liver of neonatal pigs during endotoxemia. Pediatr Res. 2008 Nov; 64(5):505-10. PMID: 18596577.
      Citations: 7     Fields:    Translation:AnimalsCells
    29. Thivierge MC, Bush JA, Suryawan A, Nguyen HV, Orellana RA, Burrin DG, Jahoor F, Davis TA. Positive net movements of amino acids in the hindlimb after overnight food deprivation contribute to sustaining the elevated anabolism of neonatal pigs. J Appl Physiol (1985). 2008 Dec; 105(6):1959-66. PMID: 18801965.
      Citations: 3     Fields:    Translation:Animals
    30. Suryawan A, Jeyapalan AS, Orellana RA, Wilson FA, Nguyen HV, Davis TA. Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activation. Am J Physiol Endocrinol Metab. 2008 Oct; 295(4):E868-75. PMID: 18682538.
      Citations: 57     Fields:    Translation:AnimalsCells
    31. Wilson FA, Suryawan A, Orellana RA, Nguyen HV, Jeyapalan AS, Gazzaneo MC, Davis TA. Fed levels of amino acids are required for the somatotropin-induced increase in muscle protein synthesis. Am J Physiol Endocrinol Metab. 2008 Oct; 295(4):E876-83. PMID: 18682537.
      Citations: 1     Fields:    Translation:AnimalsCells
    32. Wilson FA, Orellana RA, Suryawan A, Nguyen HV, Jeyapalan AS, Frank J, Davis TA. Stimulation of muscle protein synthesis by somatotropin in pigs is independent of the somatotropin-induced increase in circulating insulin. Am J Physiol Endocrinol Metab. 2008 Jul; 295(1):E187-94. PMID: 18460595.
      Citations: 2     Fields:    Translation:Animals
    33. Suryawan A, Orellana RA, Nguyen HV, Jeyapalan AS, Fleming JR, Davis TA. Activation by insulin and amino acids of signaling components leading to translation initiation in skeletal muscle of neonatal pigs is developmentally regulated. Am J Physiol Endocrinol Metab. 2007 Dec; 293(6):E1597-605. PMID: 17878222.
      Citations: 27     Fields:    Translation:AnimalsCells
    34. Orellana RA, Jeyapalan A, Escobar J, Frank JW, Nguyen HV, Suryawan A, Davis TA. Amino acids augment muscle protein synthesis in neonatal pigs during acute endotoxemia by stimulating mTOR-dependent translation initiation. Am J Physiol Endocrinol Metab. 2007 Nov; 293(5):E1416-25. PMID: 17848637.
      Citations: 13     Fields:    Translation:Animals
    35. Davis TA, Suryawan A, Orellana RA, Nguyen HV, Fiorotto ML. Postnatal ontogeny of skeletal muscle protein synthesis in pigs. J Anim Sci. 2008 Apr; 86(14 Suppl):E13-8. PMID: 17785597.
      Citations: 19     Fields:    Translation:AnimalsCells
    36. Jeyapalan AS, Orellana RA, Suryawan A, O'Connor PM, Nguyen HV, Escobar J, Frank JW, Davis TA. Glucose stimulates protein synthesis in skeletal muscle of neonatal pigs through an AMPK- and mTOR-independent process. Am J Physiol Endocrinol Metab. 2007 Aug; 293(2):E595-603. PMID: 17551002.
      Citations: 15     Fields:    Translation:AnimalsCells
    37. Moffett BS, Orellana R. Use of fenoldopam to increase urine output in a patient with renal insufficiency secondary to septic shock: A case report. Pediatr Crit Care Med. 2006 Nov; 7(6):600-2. PMID: 17006385.
      Citations: 3     Fields:    Translation:Humans
    38. Orellana RA, Kimball SR, Suryawan A, Escobar J, Nguyen HV, Jefferson LS, Davis TA. Insulin stimulates muscle protein synthesis in neonates during endotoxemia despite repression of translation initiation. Am J Physiol Endocrinol Metab. 2007 Feb; 292(2):E629-36. PMID: 17047163.
      Citations: 10     Fields:    Translation:AnimalsCells
    39. Orellana RA, O'Connor PM, Bush JA, Suryawan A, Thivierge MC, Nguyen HV, Fiorotto ML, Davis TA. Modulation of muscle protein synthesis by insulin is maintained during neonatal endotoxemia. Am J Physiol Endocrinol Metab. 2006 Jul; 291(1):E159-66. PMID: 16478773.
      Citations: 6     Fields:    Translation:AnimalsCells
    40. Thivierge MC, Bush JA, Suryawan A, Nguyen HV, Orellana RA, Burrin DG, Jahoor F, Davis TA. Whole-body and hindlimb protein breakdown are differentially altered by feeding in neonatal piglets. J Nutr. 2005 Jun; 135(6):1430-7. PMID: 15930448.
      Citations: 7     Fields:    Translation:AnimalsCells
    41. Orellana RA, Kimball SR, Nguyen HV, Bush JA, Suryawan A, Thivierge MC, Jefferson LS, Davis TA. Regulation of muscle protein synthesis in neonatal pigs during prolonged endotoxemia. Pediatr Res. 2004 Mar; 55(3):442-9. PMID: 14681494.
      Citations: 11     Fields:    Translation:AnimalsCells
    42. Suryawan A, Nguyen HV, Orellana RA, Bush JA, Davis TA. Insulin/insulin-like growth factor-I hybrid receptor abundance decreases with development in suckling pigs. J Nutr. 2003 Sep; 133(9):2783-7. PMID: 12949365.
      Citations: 3     Fields:    Translation:AnimalsCells
    43. Kimball SR, Orellana RA, O'Connor PM, Suryawan A, Bush JA, Nguyen HV, Thivierge MC, Jefferson LS, Davis TA. Endotoxin induces differential regulation of mTOR-dependent signaling in skeletal muscle and liver of neonatal pigs. Am J Physiol Endocrinol Metab. 2003 Sep; 285(3):E637-44. PMID: 12773308.
      Citations: 21     Fields:    Translation:AnimalsCells
    44. Bush JA, Kimball SR, O'Connor PM, Suryawan A, Orellana RA, Nguyen HV, Jefferson LS, Davis TA. Translational control of protein synthesis in muscle and liver of growth hormone-treated pigs. Endocrinology. 2003 Apr; 144(4):1273-83. PMID: 12639910.
      Citations: 14     Fields:    Translation:AnimalsCells
    45. Orellana RA, O'Connor PM, Nguyen HV, Bush JA, Suryawan A, Thivierge MC, Fiorotto ML, Davis TA. Endotoxemia reduces skeletal muscle protein synthesis in neonates. Am J Physiol Endocrinol Metab. 2002 Nov; 283(5):E909-16. PMID: 12376317.
      Citations: 16     Fields:    Translation:AnimalsCells
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