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RAY CHANG

TitleInstructor
InstitutionBaylor College of Medicine
DepartmentDepartment of Physical Medicine & Rehabilitation
DivisionDepartment of Physical Medicine & R
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Mi XS, Feng Q, Lo ACY, Chang RC, Chung SK, So KF. Lycium barbarum polysaccharides related RAGE and Aß levels in the retina of mice with acute ocular hypertension and promote maintenance of blood retinal barrier. Neural Regen Res. 2020 Dec; 15(12):2344-2352. PMID: 32594059.
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    2. Machhi J, Herskovitz J, Senan AM, Dutta D, Nath B, Oleynikov MD, Blomberg WR, Meigs DD, Hasan M, Patel M, Kline P, Chang RC, Chang L, Gendelman HE, Kevadiya BD. The Natural History, Pathobiology, and Clinical Manifestations of SARS-CoV-2 Infections. J Neuroimmune Pharmacol. 2020 Jul 21. PMID: 32696264.
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    3. Goto T, Kuramoto E, Dhar A, Wang RP, Seki H, Iwai H, Yamanaka A, Matsumoto SE, Hara H, Michikawa M, Ohyagi Y, Leung WK, Chang RC. Neurodegeneration of Trigeminal Mesencephalic Neurons by the Tooth Loss Triggers the Progression of Alzheimer's Disease in 3×Tg-AD Model Mice. J Alzheimers Dis. 2020 Jul 09. PMID: 32651317.
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    4. Chang R, Yan Q, Kingshott P, Tsai WB, Wang PY. Harnessing the perinuclear actin cap (pnAC) to influence nanocarrier trafficking and gene transfection efficiency in skeletal myoblasts using nanopillars. Acta Biomater. 2020 07 15; 111:221-231. PMID: 32442782.
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    5. Chen XK, Kwan JS, Chang RC, Ma AC. 1-phenyl 2-thiourea (PTU) activates autophagy in zebrafish embryos. Autophagy. 2020 Apr 22; 1-10. PMID: 32286915.
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    6. Wong CW, Wang Y, Liu T, Li L, Cheung SKK, Or PM, Cheng AS, Choy KW, Burbach JPH, Feng B, Chang RCC, Chan AM. Autism-associated PTEN missense mutation leads to enhanced nuclear localization and neurite outgrowth in an induced pluripotent stem cell line. FEBS J. 2020 Mar 09. PMID: 32150788.
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    7. Liu H, Fang C, Gong Z, Chang RC, Qian J, Gao H, Lin Y. Fundamental Characteristics of Neuron Adhesion Revealed by Forced Peeling and Time-Dependent Healing. Biophys J. 2020 Apr 21; 118(8):1811-1819. PMID: 32197062.
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    8. Ho YS, Zhao FY, Yeung WF, Wong GT, Zhang HQ, Chang RC. Application of Acupuncture to Attenuate Immune Responses and Oxidative Stress in Postoperative Cognitive Dysfunction: What Do We Know So Far? Oxid Med Cell Longev. 2020; 2020:9641904. PMID: 32148660.
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    9. Liu Y, Chu JMT, Yan T, Zhang Y, Chen Y, Chang RCC, Wong GTC. Short-term resistance exercise inhibits neuroinflammation and attenuates neuropathological changes in 3xTg Alzheimer's disease mice. J Neuroinflammation. 2020 Jan 03; 17(1):4. PMID: 31900170.
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    10. Wang RP, Ho YS, Leung WK, Goto T, Chang RC. Systemic inflammation linking chronic periodontitis to cognitive decline. Brain Behav Immun. 2019 10; 81:63-73. PMID: 31279681.
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    11. Shao X, You R, Hui TH, Fang C, Gong Z, Yan Z, Chang RCC, Shenoy VB, Lin Y. Tension- and Adhesion-Regulated Retraction of Injured Axons. Biophys J. 2019 07 23; 117(2):193-202. PMID: 31278003.
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    12. Huang C, Ng OT, Chu JM, Irwin MG, Hu X, Zhu S, Chang RC, Wong GT. Differential effects of propofol and dexmedetomidine on neuroinflammation induced by systemic endotoxin lipopolysaccharides in adult mice. Neurosci Lett. 2019 08 10; 707:134309. PMID: 31158431.
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    13. Lam NC, Yeung HY, Li WK, Lo HY, Yuen CF, Chang RC, Ho YS. Cognitive impairment in Irritable Bowel Syndrome (IBS): A systematic review. Brain Res. 2019 09 15; 1719:274-284. PMID: 31150650.
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    14. Shah A, Chao J, Legido-Quigley C, Chang RC. Oxyresveratrol exerts ATF4- and Grp78-mediated neuroprotection against endoplasmic reticulum stress in experimental Parkinson's disease. Nutr Neurosci. 2019 May 17; 1-16. PMID: 31100053.
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    15. Wu H, Dunnett S, Ho YS, Chang RC. The role of sleep deprivation and circadian rhythm disruption as risk factors of Alzheimer's disease. Front Neuroendocrinol. 2019 07; 54:100764. PMID: 31102663.
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    16. Liu AKL, Chau TW, Lim EJ, Ahmed I, Chang RC, Kalaitzakis ME, Graeber MB, Gentleman SM, Pearce RKB. Hippocampal CA2 Lewy pathology is associated with cholinergic degeneration in Parkinson's disease with cognitive decline. Acta Neuropathol Commun. 2019 04 25; 7(1):61. PMID: 31023342.
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    17. Yang Z, Li T, Li S, Wei M, Qi H, Shen B, Chang RC, Le W, Piao F. Altered Expression Levels of MicroRNA-132 and Nurr1 in Peripheral Blood of Parkinson's Disease: Potential Disease Biomarkers. ACS Chem Neurosci. 2019 05 15; 10(5):2243-2249. PMID: 30817108.
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    18. Chan HH, Lam HI, Choi KY, Li SZ, Lakshmanan Y, Yu WY, Chang RC, Lai JS, So KF. Delay of cone degeneration in retinitis pigmentosa using a 12-month treatment with Lycium barbarum supplement. J Ethnopharmacol. 2019 May 23; 236:336-344. PMID: 30877066.
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    19. You R, Liu Y, Chang RC. A Behavioral Test Battery for the Repeated Assessment of Motor Skills, Mood, and Cognition in Mice. J Vis Exp. 2019 03 02; (145). PMID: 30882789.
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    20. Liu Y, Yan T, Chu JM, Chen Y, Dunnett S, Ho YS, Wong GT, Chang RC. The beneficial effects of physical exercise in the brain and related pathophysiological mechanisms in neurodegenerative diseases. Lab Invest. 2019 07; 99(7):943-957. PMID: 30808929.
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    21. Shah A, Han P, Wong MY, Chang RC, Legido-Quigley C. Palmitate and Stearate are Increased in the Plasma in a 6-OHDA Model of Parkinson's Disease. Metabolites. 2019 Feb 13; 9(2). PMID: 30781729.
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    22. Chen ZX, Xu QQ, Shan CS, Shi YH, Wang Y, Chang RC, Zheng GQ. Borneol for Regulating the Permeability of the Blood-Brain Barrier in Experimental Ischemic Stroke: Preclinical Evidence and Possible Mechanism. Oxid Med Cell Longev. 2019; 2019:2936737. PMID: 30863478.
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    23. Gong Z, Fang C, You R, Shao X, Wei X, Chang RC, Lin Y. Distinct relaxation timescales of neurites revealed by rate-dependent indentation, relaxation and micro-rheology tests. Soft Matter. 2019 Jan 02; 15(2):166-174. PMID: 30420982.
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    24. Ng LHL, Huang Y, Han L, Chang RC, Chan YS, Lai CSW. Ketamine and selective activation of parvalbumin interneurons inhibit stress-induced dendritic spine elimination. Transl Psychiatry. 2018 12 10; 8(1):272. PMID: 30531859.
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    25. Chang R, Hsu CF, Tsai WB. Fabrication of Chlorophyll-Incorporated Nanogels for Potential Applications in Photothermal Cancer Therapy. ACS Omega. 2018 Nov 30; 3(11):16057-16062. PMID: 30556024.
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    26. Huang C, Chu JM, Liu Y, Chang RC, Wong GT. Varenicline reduces DNA damage, tau mislocalization and post surgical cognitive impairment in aged mice. Neuropharmacology. 2018 12; 143:217-227. PMID: 30273594.
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    27. You R, Ho YS, Hung CH, Liu Y, Huang CX, Chan HN, Ho SL, Lui SY, Li HW, Chang RC. Silica nanoparticles induce neurodegeneration-like changes in behavior, neuropathology, and affect synapse through MAPK activation. Part Fibre Toxicol. 2018 07 03; 15(1):28. PMID: 29970116.
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    28. Pang CC, Kiecker C, O'Brien JT, Noble W, Chang RC. Ammon's Horn 2 (CA2) of the Hippocampus: A Long-Known Region with a New Potential Role in Neurodegeneration. Neuroscientist. 2019 04; 25(2):167-180. PMID: 29865938.
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    29. Huang C, Irwin MG, Wong GTC, Chang RCC. Evidence of the impact of systemic inflammation on neuroinflammation from a non-bacterial endotoxin animal model. J Neuroinflammation. 2018 May 17; 15(1):147. PMID: 29776428.
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    30. Hung CH, Cheng SS, Cheung YT, Wuwongse S, Zhang NQ, Ho YS, Lee SM, Chang RC. A reciprocal relationship between reactive oxygen species and mitochondrial dynamics in neurodegeneration. Redox Biol. 2018 04; 14:7-19. PMID: 28837882.
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    31. Zhang F, Zhong R, Li S, Chang RC, Le W. The missing link between sleep disorders and age-related dementia: recent evidence and plausible mechanisms. J Neural Transm (Vienna). 2017 05; 124(5):559-568. PMID: 28188439.
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    32. Wu YL, Maachani UB, Schweitzer M, Singh R, Wang M, Chang R, Souweidane MM. Dual Inhibition of PI3K/AKT and MEK/ERK Pathways Induces Synergistic Antitumor Effects in Diffuse Intrinsic Pontine Glioma Cells. Transl Oncol. 2017 Apr; 10(2):221-228. PMID: 28189993.
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    33. Tosi U, Marnell CS, Chang R, Cho WC, Ting R, Maachani UB, Souweidane MM. Advances in Molecular Imaging of Locally Delivered Targeted Therapeutics for Central Nervous System Tumors. Int J Mol Sci. 2017 Feb 08; 18(2). PMID: 28208698.
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    34. Chang R, Mas MF, Joseph PJ, Verduzco-Gutierrez M. Poster 345 Rehabilitation of Bickerstaff Brainstem Encephalitis: A Case Report. PM R. 2016 Sep; 8(9S):S273. PMID: 27673099.
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    35. Yu SS, Tang X, Ho YS, Chang RC, Chiu K. Links between the Brain and Retina: The Effects of Cigarette Smoking-Induced Age-Related Changes in Alzheimer's Disease and Macular Degeneration. Front Neurol. 2016; 7:119. PMID: 27512384.
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    36. Lai HM, Liu AK, Ng WL, DeFelice J, Lee WS, Li H, Li W, Ng HM, Chang RC, Lin B, Wu W, Gentleman SM. Rationalisation and Validation of an Acrylamide-Free Procedure in Three-Dimensional Histological Imaging. PLoS One. 2016; 11(6):e0158628. PMID: 27359336.
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    37. Ying M, Sui X, Zhang Y, Sun Q, Qu Z, Luo X, Chang RC, Ni J, Liu J, Yang X. Identification of Novel Key Molecules Involved in Spatial Memory Impairment in Triple Transgenic Mice of Alzheimer's Disease. Mol Neurobiol. 2017 07; 54(5):3843-3858. PMID: 27335030.
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    38. Xing R, Zhang Y, Xu H, Luo X, Chang RC, Liu J, Yang X. Spatial memory impairment by TRPC1 depletion is ameliorated by environmental enrichment. Oncotarget. 2016 May 10; 7(19):27855-73. PMID: 27034165.
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    39. Chang RC. Editorial. Am J Alzheimers Dis Other Demen. 2016 May; 31(3):193. PMID: 27099382.
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    40. Sy LK, Lok CN, Wang JY, Liu Y, Cheng L, Wan PK, Leung CT, Cao B, Kwong WL, Chang RC, Che CM. Identification of "sarsasapogenin-aglyconed" timosaponins as novel Aß-lowering modulators of amyloid precursor protein processing. Chem Sci. 2016 May 01; 7(5):3206-3214. PMID: 29997812.
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    41. Huang C, Ng OT, Ho YS, Irwin MG, Chang RC, Wong GT. Effect of Continuous Propofol Infusion in Rat on Tau Phosphorylation with or without Temperature Control. J Alzheimers Dis. 2016; 51(1):213-26. PMID: 26836157.
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    42. Liu Q, Yang X, Chang RC. Editorial: Bioactive Small Molecules in Regulating Inflammation and Metabolic Disorder. Curr Top Med Chem. 2016; 16(8):809-10. PMID: 26381415.
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    43. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
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    44. Yang X, Zhang Y, Xu H, Luo X, Yu J, Liu J, Chang RC. Neuroprotection of Coenzyme Q10 in Neurodegenerative Diseases. Curr Top Med Chem. 2016; 16(8):858-66. PMID: 26311425.
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    45. Alexandris A, Liu AK, Chang RC, Pearce RK, Gentleman SM. Differential expression of galanin in the cholinergic basal forebrain of patients with Lewy body disorders. Acta Neuropathol Commun. 2015 Dec 01; 3:77. PMID: 26621352.
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    46. Wang H, Lau BW, Wang NL, Wang SY, Lu QJ, Chang RC, So KF. Lycium barbarum polysaccharides promotes in vivo proliferation of adult rat retinal progenitor cells. Neural Regen Res. 2015 Dec; 10(12):1976-81. PMID: 26889185.
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    47. Poon DC, Ho YS, You R, Tse HL, Chiu K, Chang RC. PKR deficiency alters E. coli-induced sickness behaviors but does not exacerbate neuroimmune responses or bacterial load. J Neuroinflammation. 2015 Nov 19; 12:212. PMID: 26585788.
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    48. Asthana P, Vong JS, Kumar G, Chang RC, Zhang G, Sheikh KA, Ma CH. Dissecting the Role of Anti-ganglioside Antibodies in Guillain-Barré Syndrome: an Animal Model Approach. Mol Neurobiol. 2016 09; 53(7):4981-91. PMID: 26374552.
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    49. Poon DC, Ho YS, Chiu K, Wong HL, Chang RC. Sickness: From the focus on cytokines, prostaglandins, and complement factors to the perspectives of neurons. Neurosci Biobehav Rev. 2015 Oct; 57:30-45. PMID: 26363665.
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    50. Zhang LQ, Sa F, Chong CM, Wang Y, Zhou ZY, Chang RC, Chan SW, Hoi PM, Yuen Lee SM. Schisantherin A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3ß pathways. J Ethnopharmacol. 2015 Jul 21; 170:8-15. PMID: 25934514.
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    51. Jiang T, Chang RC, Rosenmann H, Yu JT. Advances in Alzheimer's disease: from bench to bedside. Biomed Res Int. 2015; 2015:202676. PMID: 25789309.
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    52. Carret-Rebillat AS, Pace C, Gourmaud S, Ravasi L, Montagne-Stora S, Longueville S, Tible M, Sudol E, Chang RC, Paquet C, Mouton-Liger F, Hugon J. Neuroinflammation and Aß accumulation linked to systemic inflammation are decreased by genetic PKR down-regulation. Sci Rep. 2015 Feb 17; 5:8489. PMID: 25687824.
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    53. Liu AK, Chang RC, Pearce RK, Gentleman SM. Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer's and Parkinson's disease. Acta Neuropathol. 2015 Apr; 129(4):527-40. PMID: 25633602.
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    54. Li HY, Ruan YW, Kau PW, Chiu K, Chang RC, Chan HH, So KF. Effect of Lycium barbarum (Wolfberry) on alleviating axonal degeneration after partial optic nerve transection. Cell Transplant. 2015; 24(3):403-17. PMID: 25622224.
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    55. Ho WL, Leung Y, Cheng SS, Lok CK, Ho YS, Baum L, Yang X, Chiu K, Chang RC. Investigating degeneration of the retina in young and aged tau P301L mice. Life Sci. 2015 Mar 01; 124:16-23. PMID: 25592136.
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    56. Huang C, Ho YS, Ng OT, Irwin MG, Chang RC, Wong GT. Dexmedetomidine directly increases tau phosphorylation. J Alzheimers Dis. 2015; 44(3):839-50. PMID: 25374108.
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    57. Yu J, Luo X, Xu H, Ma Q, Yuan J, Li X, Chang RC, Qu Z, Huang X, Zhuang Z, Liu J, Yang X. Identification of the key molecules involved in chronic copper exposure-aggravated memory impairment in transgenic mice of Alzheimer's disease using proteomic analysis. J Alzheimers Dis. 2015; 44(2):455-69. PMID: 25352456.
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    58. Xiao J, Xing F, Huo J, Fung ML, Liong EC, Ching YP, Xu A, Chang RC, So KF, Tipoe GL. Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model. Sci Rep. 2014 Jul 07; 4:5587. PMID: 24998389.
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    59. Lau CF, Ho YS, Hung CH, Wuwongse S, Poon CH, Chiu K, Yang X, Chu LW, Chang RC. Protective effects of testosterone on presynaptic terminals against oligomeric ß-amyloid peptide in primary culture of hippocampal neurons. Biomed Res Int. 2014; 2014:103906. PMID: 25045655.
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    60. He M, Pan H, Chang RC, So KF, Brecha NC, Pu M. Activation of the Nrf2/HO-1 antioxidant pathway contributes to the protective effects of Lycium barbarum polysaccharides in the rodent retina after ischemia-reperfusion-induced damage. PLoS One. 2014; 9(1):e84800. PMID: 24400114.
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    61. Chang RC, Ho YS, Wong S, Gentleman SM, Ng HK. Neuropathology of cigarette smoking. Acta Neuropathol. 2014 Jan; 127(1):53-69. PMID: 24240736.
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    62. Xu M, Chen X, Gu Y, Peng T, Yang D, Chang RC, So KF, Liu K, Shen J. Baicalin can scavenge peroxynitrite and ameliorate endogenous peroxynitrite-mediated neurotoxicity in cerebral ischemia-reperfusion injury. J Ethnopharmacol. 2013 Oct 28; 150(1):116-24. PMID: 23973788.
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    63. Wuwongse S, Cheng SS, Wong GT, Hung CH, Zhang NQ, Ho YS, Law AC, Chang RC. Effects of corticosterone and amyloid-beta on proteins essential for synaptic function: implications for depression and Alzheimer's disease. Biochim Biophys Acta. 2013 Dec; 1832(12):2245-56. PMID: 23928361.
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    64. Sen A, Wang Y, Chiu K, Whiley L, Cowan D, Chang RC, Legido-Quigley C. Metabolic phenotype of the healthy rodent model using in-vial extraction of dried serum, urine, and cerebrospinal fluid spots. Anal Chem. 2013 Aug 06; 85(15):7257-63. PMID: 23845063.
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    65. Li H, Liang Y, Chiu K, Yuan Q, Lin B, Chang RC, So KF. Lycium barbarum (wolfberry) reduces secondary degeneration and oxidative stress, and inhibits JNK pathway in retina after partial optic nerve transection. PLoS One. 2013; 8(7):e68881. PMID: 23894366.
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    66. Mi XS, Zhong JX, Chang RC, So KF. Research advances on the usage of traditional Chinese medicine for neuroprotection in glaucoma. J Integr Med. 2013 Jul; 11(4):233-40. PMID: 23867241.
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    67. Xiao J, Guo R, Fung ML, Liong EC, Chang RC, Ching YP, Tipoe GL. Garlic-Derived S-Allylmercaptocysteine Ameliorates Nonalcoholic Fatty Liver Disease in a Rat Model through Inhibition of Apoptosis and Enhancing Autophagy. Evid Based Complement Alternat Med. 2013; 2013:642920. PMID: 23861709.
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    68. Chiu PW, Mak HK, Yau KK, Chan Q, Chang RC, Chu LW. Metabolic changes in the anterior and posterior cingulate cortices of the normal aging brain: proton magnetic resonance spectroscopy study at 3 T. Age (Dordr). 2014 Feb; 36(1):251-64. PMID: 23709317.
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    69. Zhang YK, Wang J, Liu L, Chang RC, So KF, Ju G. The effect of Lycium barbarum on spinal cord injury, particularly its relationship with M1 and M2 macrophage in rats. BMC Complement Altern Med. 2013 Mar 22; 13:67. PMID: 23517687.
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    70. Poon DC, Ho YS, Chiu K, Chang RC. Cytokines: how important are they in mediating sickness? Neurosci Biobehav Rev. 2013 Jan; 37(1):1-10. PMID: 23153795.
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    71. Ho WL, Leung Y, Tsang AW, So KF, Chiu K, Chang RC. Review: tauopathy in the retina and optic nerve: does it shadow pathological changes in the brain? Mol Vis. 2012; 18:2700-10. PMID: 23170062.
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    72. Zhang E, Yau SY, Lau BW, Ma H, Lee TM, Chang RC, So KF. Synaptic plasticity, but not hippocampal neurogenesis, mediated the counteractive effect of wolfberry on depression in rats(1). Cell Transplant. 2012; 21(12):2635-49. PMID: 23127884.
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    73. Mi XS, Feng Q, Lo AC, Chang RC, Lin B, Chung SK, So KF. Protection of retinal ganglion cells and retinal vasculature by Lycium barbarum polysaccharides in a mouse model of acute ocular hypertension. PLoS One. 2012; 7(10):e45469. PMID: 23094016.
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    74. Wong GT, Chang RC, Law AC. A breach in the scaffold: the possible role of cytoskeleton dysfunction in the pathogenesis of major depression. Ageing Res Rev. 2013 Jan; 12(1):67-75. PMID: 22995339.
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    75. Zhang L, Chang RC, Chu LW, Mak HK. Current neuroimaging techniques in Alzheimer's disease and applications in animal models. Am J Nucl Med Mol Imaging. 2012; 2(3):386-404. PMID: 23133824.
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    76. Zhu Q, Zhang NQ, Lau CF, Chao J, Sun Z, Chang RC, Chen F, Wang M. In vitro attenuation of acrolein-induced toxicity by phloretin, a phenolic compound from apple. Food Chem. 2012 Dec 01; 135(3):1762-8. PMID: 22953919.
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    77. Chao J, Leung Y, Wang M, Chang RC. Nutraceuticals and their preventive or potential therapeutic value in Parkinson's disease. Nutr Rev. 2012 Jul; 70(7):373-86. PMID: 22747840.
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    78. Ho YS, Yang X, Yeung SC, Chiu K, Lau CF, Tsang AW, Mak JC, Chang RC. Cigarette smoking accelerated brain aging and induced pre-Alzheimer-like neuropathology in rats. PLoS One. 2012; 7(5):e36752. PMID: 22606286.
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    79. Lau BW, Lee JC, Li Y, Fung SM, Sang YH, Shen J, Chang RC, So KF. Polysaccharides from wolfberry prevents corticosterone-induced inhibition of sexual behavior and increases neurogenesis. PLoS One. 2012; 7(4):e33374. PMID: 22523540.
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    80. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490.
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    81. Mi XS, Chiu K, Van G, Leung JW, Lo AC, Chung SK, Chang RC, So KF. Effect of Lycium barbarum Polysaccharides on the expression of endothelin-1 and its receptors in an ocular hypertension model of rat glaucoma. Neural Regen Res. 2012 Mar 25; 7(9):645-51. PMID: 25745457.
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    82. Yang D, Li SY, Yeung CM, Chang RC, So KF, Wong D, Lo AC. Lycium barbarum extracts protect the brain from blood-brain barrier disruption and cerebral edema in experimental stroke. PLoS One. 2012; 7(3):e33596. PMID: 22438957.
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    83. Chan TF, Chiu K, Lok CK, Lau HW, So KF, Chang RC. Morphometric analyses of retinal sections. J Vis Exp. 2012 Feb 19; (60). PMID: 22370760.
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    84. Ho YS, Yang X, Lau JC, Hung CH, Wuwongse S, Zhang Q, Wang J, Baum L, So KF, Chang RC. Endoplasmic reticulum stress induces tau pathology and forms a vicious cycle: implication in Alzheimer's disease pathogenesis. J Alzheimers Dis. 2012; 28(4):839-54. PMID: 22101233.
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    85. Ho YS, Poon DC, Chan TF, Chang RC. From small to big molecules: how do we prevent and delay the progression of age-related neurodegeneration? Curr Pharm Des. 2012; 18(1):15-26. PMID: 22211681.
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    86. Xiao J, Liong EC, Ching YP, Chang RC, So KF, Fung ML, Tipoe GL. Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation. J Ethnopharmacol. 2012 Jan 31; 139(2):462-70. PMID: 22138659.
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    87. Chiu K, Chan TF, Wu A, Leung IY, So KF, Chang RC. Neurodegeneration of the retina in mouse models of Alzheimer's disease: what can we learn from the retina? Age (Dordr). 2012 Jun; 34(3):633-49. PMID: 21559868.
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    88. Ho YS, So KF, Chang RC. Drug discovery from Chinese medicine against neurodegeneration in Alzheimer's and vascular dementia. Chin Med. 2011 Apr 22; 6:15. PMID: 21513513.
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    89. Shen F, Smith JA, Chang R, Bourdet DL, Tsuruda PR, Obedencio GP, Beattie DT. 5-HT(4) receptor agonist mediated enhancement of cognitive function in vivo and amyloid precursor protein processing in vitro: A pharmacodynamic and pharmacokinetic assessment. Neuropharmacology. 2011 Jul-Aug; 61(1-2):69-79. PMID: 21392515.
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    90. Cheung YT, Zhang NQ, Hung CH, Lai CS, Yu MS, So KF, Chang RC. Temporal relationship of autophagy and apoptosis in neurons challenged by low molecular weight ß-amyloid peptide. J Cell Mol Med. 2011 Feb; 15(2):244-57. PMID: 20015199.
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    91. Li SY, Yang D, Yeung CM, Yu WY, Chang RC, So KF, Wong D, Lo AC. Lycium barbarum polysaccharides reduce neuronal damage, blood-retinal barrier disruption and oxidative stress in retinal ischemia/reperfusion injury. PLoS One. 2011 Jan 26; 6(1):e16380. PMID: 21298100.
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    92. Lau BW, Ren C, Yang J, Yan SW, Chang RC, Pu M, So KF. Light deprivation induces depression-like behavior and suppresses neurogenesis in diurnal mongolian gerbil (Meriones unguiculatus). Cell Transplant. 2011; 20(6):871-81. PMID: 21054936.
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    93. Zheng ZP, Ma J, Cheng KW, Chao J, Zhu Q, Chang RC, Zhao M, Lin ZX, Wang M. Sulfur-containing constituents and one 1H-pyrrole-2-carboxylic acid derivative from pineapple [Ananas comosus (L.) Merr.] fruit. Phytochemistry. 2010 Dec; 71(17-18):2046-51. PMID: 20843530.
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    94. Peng X, Ma J, Chao J, Sun Z, Chang RC, Tse I, Li ET, Chen F, Wang M. Beneficial effects of cinnamon proanthocyanidins on the formation of specific advanced glycation endproducts and methylglyoxal-induced impairment on glucose consumption. J Agric Food Chem. 2010 Jun 09; 58(11):6692-6. PMID: 20476737.
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    95. Hung CH, Ho YS, Chang RC. Modulation of mitochondrial calcium as a pharmacological target for Alzheimer's disease. Ageing Res Rev. 2010 Oct; 9(4):447-56. PMID: 20553970.
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    96. Chiu K, Zhou Y, Yeung SC, Lok CK, Chan OO, Chang RC, So KF, Chiu JF. Up-regulation of crystallins is involved in the neuroprotective effect of wolfberry on survival of retinal ganglion cells in rat ocular hypertension model. J Cell Biochem. 2010 May 15; 110(2):311-20. PMID: 20336662.
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    97. Wuwongse S, Chang RC, Law AC. The putative neurodegenerative links between depression and Alzheimer's disease. Prog Neurobiol. 2010 Aug; 91(4):362-75. PMID: 20441786.
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    98. Yu HT, Chan WW, Chai KH, Lee CW, Chang RC, Yu MS, McLoughlin DM, Miller CC, Lau KF. Transcriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1. J Cell Biochem. 2010 Mar 01; 109(4):782-93. PMID: 20091743.
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    99. Chiu K, Yeung SC, So KF, Chang RC. Modulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma. Cell Mol Immunol. 2010 Jan; 7(1):61-8. PMID: 20081877.
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    100. Ho YS, Yu MS, Yang XF, So KF, Yuen WH, Chang RC. Neuroprotective effects of polysaccharides from wolfberry, the fruits of Lycium barbarum, against homocysteine-induced toxicity in rat cortical neurons. J Alzheimers Dis. 2010; 19(3):813-27. PMID: 20157238.
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    101. Chao J, Lau WK, Huie MJ, Ho YS, Yu MS, Lai CS, Wang M, Yuen WH, Lam WH, Chan TH, Chang RC. A pro-drug of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) prevents differentiated SH-SY5Y cells from toxicity induced by 6-hydroxydopamine. Neurosci Lett. 2010 Jan 29; 469(3):360-4. PMID: 20026175.
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    102. Ho YS, Yu MS, Yik SY, So KF, Yuen WH, Chang RC. Polysaccharides from wolfberry antagonizes glutamate excitotoxicity in rat cortical neurons. Cell Mol Neurobiol. 2009 Dec; 29(8):1233-44. PMID: 19499323.
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    103. Ho YS, So KF, Chang RC. Anti-aging herbal medicine--how and why can they be used in aging-associated neurodegenerative diseases? Ageing Res Rev. 2010 Jul; 9(3):354-62. PMID: 19833234.
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    104. Hugon J, Paquet C, Chang RC. Could PKR inhibition modulate human neurodegeneration? Expert Rev Neurother. 2009 Oct; 9(10):1455-7. PMID: 19831834.
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    105. Chang RC, Chiu K, Ho YS, So KF. Modulation of neuroimmune responses on glia in the central nervous system: implication in therapeutic intervention against neuroinflammation. Cell Mol Immunol. 2009 Oct; 6(5):317-26. PMID: 19887044.
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    106. Chiu K, Chan HC, Yeung SC, Yuen WH, Zee SY, Chang RC, So KF. Erratum: Modulation of microglia by Wolfberry on the survival of retinal ganglion cells in a rat ocular hypertension model. J Ocul Biol Dis Infor. 2009 Sep; 2(3):127-136. PMID: 20046845.
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    107. Yu JT, Chang RC, Tan L. Calcium dysregulation in Alzheimer's disease: from mechanisms to therapeutic opportunities. Prog Neurobiol. 2009 Nov; 89(3):240-55. PMID: 19664678.
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    108. Chiu K, Chan HC, Yeung SC, Yuen WH, Zee SY, Chang RC, So KF. Modulation of microglia by Wolfberry on the survival of retinal ganglion cells in a rat ocular hypertension model. J Ocul Biol Dis Infor. 2009 Jun; 2(2):47-56. PMID: 19672466.
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    109. Chao J, Li H, Cheng KW, Yu MS, Chang RC, Wang M. Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. J Nutr Biochem. 2010 Jun; 21(6):482-9. PMID: 19443200.
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    110. Lai CS, Preisler J, Baum L, Lee DH, Ng HK, Hugon J, So KF, Chang RC. Low molecular weight Abeta induces collapse of endoplasmic reticulum. Mol Cell Neurosci. 2009 May; 41(1):32-43. PMID: 19386229.
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    111. Cheung YT, Lau WK, Yu MS, Lai CS, Yeung SC, So KF, Chang RC. Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research. Neurotoxicology. 2009 Jan; 30(1):127-35. PMID: 19056420.
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    112. Lau KF, Chan WM, Perkinton MS, Tudor EL, Chang RC, Chan HY, McLoughlin DM, Miller CC. Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription. J Biol Chem. 2008 Dec 12; 283(50):34728-37. PMID: 18922798.
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    113. Chao J, Yu MS, Ho YS, Wang M, Chang RC. Dietary oxyresveratrol prevents parkinsonian mimetic 6-hydroxydopamine neurotoxicity. Free Radic Biol Med. 2008 Oct 01; 45(7):1019-26. PMID: 18675900.
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    114. Chiu K, Lau WM, Yeung SC, Chang RC, So KF. Retrograde labeling of retinal ganglion cells by application of fluoro-gold on the surface of superior colliculus. J Vis Exp. 2008 Jun 17; (16). PMID: 19066544.
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    115. Sauter A, Stern-Straeter J, Chang RC, Hörmann K, Naim R. Influence of interleukin-13 on beta-catenin levels in eosinophilic chronic rhinosinusitis cell culture. Int J Mol Med. 2008 Apr; 21(4):447-52. PMID: 18360690.
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    116. Chiu K, Chang R, So KF. Laser-induced chronic ocular hypertension model on SD rats. J Vis Exp. 2007; (10):549. PMID: 18989402.
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    117. Lai CS, Yu MS, Yuen WH, So KF, Zee SY, Chang RC. Antagonizing beta-amyloid peptide neurotoxicity of the anti-aging fungus Ganoderma lucidum. Brain Res. 2008 Jan 23; 1190:215-24. PMID: 18083148.
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    118. Chiu K, Chang RC, So KF. Intravitreous injection for establishing ocular diseases model. J Vis Exp. 2007; (8):313. PMID: 18989417.
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    119. Chiu K, Lau WM, Lau HT, So KF, Chang RC. Micro-dissection of rat brain for RNA or protein extraction from specific brain region. J Vis Exp. 2007; (7):269. PMID: 18989440.
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    120. Chang RC, So KF. Use of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases. What do we know so far? Cell Mol Neurobiol. 2008 Aug; 28(5):643-52. PMID: 17710531.
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    121. Yu MS, Lai CS, Ho YS, Zee SY, So KF, Yuen WH, Chang RC. Characterization of the effects of anti-aging medicine Fructus lycii on beta-amyloid peptide neurotoxicity. Int J Mol Med. 2007 Aug; 20(2):261-8. PMID: 17611646.
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    122. Waterhouse RN, Chang RC, Atuehene N, Collier TL. In vitro and in vivo binding of neuroactive steroids to the sigma-1 receptor as measured with the positron emission tomography radioligand [18F]FPS. Synapse. 2007 Jul; 61(7):540-6. PMID: 17447254.
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    123. Chang RC, Yu MS, Lai CS. Significance of molecular signaling for protein translation control in neurodegenerative diseases. Neurosignals. 2006-2007; 15(5):249-58. PMID: 17496426.
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    124. Ho YS, Yu MS, Lai CS, So KF, Yuen WH, Chang RC. Characterizing the neuroprotective effects of alkaline extract of Lycium barbarum on beta-amyloid peptide neurotoxicity. Brain Res. 2007 Jul 16; 1158:123-34. PMID: 17568570.
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    125. Yu MS, Wong AY, So KF, Fang JN, Yuen WH, Chang RC. New polysaccharide from Nerium indicum protects neurons via stress kinase signaling pathway. Brain Res. 2007 Jun 11; 1153:221-30. PMID: 17475226.
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    126. Chan HC, Chang RC, Koon-Ching Ip A, Chiu K, Yuen WH, Zee SY, So KF. Neuroprotective effects of Lycium barbarum Lynn on protecting retinal ganglion cells in an ocular hypertension model of glaucoma. Exp Neurol. 2007 Jan; 203(1):269-73. PMID: 17045262.
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    127. Yu MS, Ho YS, So KF, Yuen WH, Chang RC. Cytoprotective effects of Lycium barbarum against reducing stress on endoplasmic reticulum. Int J Mol Med. 2006 Jun; 17(6):1157-61. PMID: 16685430.
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    128. Yu MS, Suen KC, Kwok NS, So KF, Hugon J, Chang RC. Beta-amyloid peptides induces neuronal apoptosis via a mechanism independent of unfolded protein responses. Apoptosis. 2006 May; 11(5):687-700. PMID: 16532272.
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    129. Waterhouse RN, Chang RC, Zhao J, Carambot PE. In vivo evaluation in rats of [(18)F]1-(2-fluoroethyl)-4-[(4-cyanophenoxy)methyl]piperidine as a potential radiotracer for PET assessment of CNS sigma-1 receptors. Nucl Med Biol. 2006 Feb; 33(2):211-5. PMID: 16546675.
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    130. Lai SW, Yu MS, Yuen WH, Chang RC. Novel neuroprotective effects of the aqueous extracts from Verbena officinalis Linn. Neuropharmacology. 2006 May; 50(6):641-50. PMID: 16406021.
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    131. Fang X, Yu MM, Yuen WH, Zee SY, Chang RC. Immune modulatory effects of Prunella vulgaris L. on monocytes/macrophages. Int J Mol Med. 2005 Dec; 16(6):1109-16. PMID: 16273294.
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    132. Wong HL, Wang X, Chang RC, Jin DY, Feng H, Wang Q, Lo KW, Huang DP, Yuen PW, Takada K, Wong YC, Tsao SW. Stable expression of EBERs in immortalized nasopharyngeal epithelial cells confers resistance to apoptotic stress. Mol Carcinog. 2005 Oct; 44(2):92-101. PMID: 16086371.
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    133. Naim R, Chang RC, Alfano SS, Riedel F, Bayerl C, Sadick H, Bran G, Hormann K. Targeting TGF-beta1 increases hepatocyte growth factor (HGF/SF) levels in external auditory canal cholesteatoma (EACC) epithelial cell culture. Regul Pept. 2005 Aug 15; 130(1-2):75-80. PMID: 15913806.
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    134. Yu MS, Leung SK, Lai SW, Che CM, Zee SY, So KF, Yuen WH, Chang RC. Neuroprotective effects of anti-aging oriental medicine Lycium barbarum against beta-amyloid peptide neurotoxicity. Exp Gerontol. 2005 Aug-Sep; 40(8-9):716-27. PMID: 16139464.
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    135. Naim R, Chang RC, Anders C, Sadick H, Riedel F, Bayerl C, Bran G, Hormann K. Up-regulation of beta-catenin in external auditory canal cholesteatoma. Int J Mol Med. 2005 May; 15(5):801-4. PMID: 15806301.
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    136. Fang X, Chang RC, Yuen WH, Zee SY. Immune modulatory effects of Prunella vulgaris L. Int J Mol Med. 2005 Mar; 15(3):491-6. PMID: 15702244.
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    137. Yu MS, Lai SW, Lin KF, Fang JN, Yuen WH, Chang RC. Characterization of polysaccharides from the flowers of Nerium indicum and their neuroprotective effects. Int J Mol Med. 2004 Nov; 14(5):917-24. PMID: 15492866.
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    138. Lin KF, Chang RC, Suen KC, So KF, Hugon J. Modulation of calcium/calmodulin kinase-II provides partial neuroprotection against beta-amyloid peptide toxicity. Eur J Neurosci. 2004 Apr; 19(8):2047-55. PMID: 15090032.
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    139. Chang RC, Stout S, Miller RR. Comparing excitatory backward and forward conditioning. Q J Exp Psychol B. 2004 Jan; 57(1):1-23. PMID: 14690847.
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    140. Suen KC, Lin KF, Elyaman W, So KF, Chang RC, Hugon J. Reduction of calcium release from the endoplasmic reticulum could only provide partial neuroprotection against beta-amyloid peptide toxicity. J Neurochem. 2003 Dec; 87(6):1413-26. PMID: 14713297.
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    141. Suen KC, Yu MS, So KF, Chang RC, Hugon J. Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in beta-amyloid peptide neurotoxicity. J Biol Chem. 2003 Dec 12; 278(50):49819-27. PMID: 12975376.
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    142. Elyaman W, Terro F, Suen KC, Yardin C, Chang RC, Hugon J. BAD and Bcl-2 regulation are early events linking neuronal endoplasmic reticulum stress to mitochondria-mediated apoptosis. Brain Res Mol Brain Res. 2002 Dec 30; 109(1-2):233-8. PMID: 12531534.
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    143. Chang RC, Wong AK, Ng HK, Hugon J. Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease. Neuroreport. 2002 Dec 20; 13(18):2429-32. PMID: 12499843.
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    144. Chang RC, Suen KC, Ma CH, Elyaman W, Ng HK, Hugon J. Involvement of double-stranded RNA-dependent protein kinase and phosphorylation of eukaryotic initiation factor-2alpha in neuronal degeneration. J Neurochem. 2002 Dec; 83(5):1215-25. PMID: 12437593.
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    145. Jeohn GH, Cooper CL, Wilson B, Chang RC, Jang KJ, Kim HC, Liu B, Hong JS. p38 MAP kinase is involved in lipopolysaccharide-induced dopaminergic neuronal cell death in rat mesencephalic neuron-glia cultures. Ann N Y Acad Sci. 2002 May; 962:332-46. PMID: 12076985.
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