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PAUL KLOTMAN

TitlePresident
InstitutionBaylor College of Medicine
DepartmentOffice of the President
DivisionOffice of the President
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-Nephrology


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    P01DK038108     (COFFMAN, THOMAS M)Aug 1, 1988 - Jan 31, 2011
    NIH/NIDDK
    Pathophysiology of Renal Allograft Dysfunction
    Role: Co-Principal Investigator

    P01DK050795     (KLOTMAN, PAUL EVAN)Sep 30, 1996 - Jul 31, 2003
    NIH/NIDDK
    MOLECULAR THERAPY FOR RENAL DISEASE
    Role: Principal Investigator

    T32DK007757     (HE, JOHN C)Jul 1, 1998 - Sep 14, 2019
    NIH/NIDDK
    Molecular Basis of Renal Diseases
    Role: Co-Principal Investigator

    P01DK056492     (KLOTMAN, PAUL EVAN)Sep 15, 1999 - Apr 30, 2022
    NIH/NIDDK
    Long-term consequences of HIV in the Kidney
    Role: Principal Investigator

    R13DK058334     (KLOTMAN, PAUL EVAN)Jun 1, 2000 - May 31, 2001
    NIH/NIDDK
    FOREFRONTS IN NEPHROLOGY SYMPOSIUM--GENE THERAPY
    Role: Principal Investigator

    R01DK063610     (KLOTMAN, PAUL EVAN)Jun 20, 2002 - Jan 31, 2007
    NIH/NIDDK
    Mechanisms of Nucleic acid Uptake by Renal Epithelium
    Role: Principal Investigator

    RC4DK090860     (KLOTMAN, PAUL EVAN)Sep 30, 2010 - Sep 29, 2013
    NIH/NIDDK
    RNA profiling of HIV-associated nephropathy in patients with the MYH9 risk allele
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Li H, Zhang W, Zhong F, Das GC, Xie Y, Li Z, Cai W, Jiang G, Choi J, Sidani M, Hyink DP, Lee K, Klotman PE, He JC. Epigenetic regulation of RCAN1 expression in kidney disease and its role in podocyte injury. Kidney Int. 2018 12; 94(6):1160-1176. PMID: 30366682.
      View in: PubMed
    2. Cheung JY, Gordon J, Wang J, Song J, Zhang XQ, Prado FJ, Shanmughapriya S, Rajan S, Tomar D, Tahrir FG, Gupta MK, Knezevic T, Merabova N, Kontos CD, McClung JM, Klotman PE, Madesh M, Khalili K, Feldman AM. Mitochondrial dysfunction in human immunodeficiency virus-1 transgenic mouse cardiac myocytes. J Cell Physiol. 2019 Apr; 234(4):4432-4444. PMID: 30256393.
      View in: PubMed
    3. Cheung JY, Gordon J, Wang J, Song J, Zhang XQ, Tilley DG, Gao E, Koch WJ, Rabinowitz J, Klotman PE, Khalili K, Feldman AM. Cardiac Dysfunction in HIV-1 Transgenic Mouse: Role of Stress and BAG3. Clin Transl Sci. 2015 Aug; 8(4):305-10. PMID: 26300236.
      View in: PubMed
    4. Razzak Chaudhary S, Workeneh BT, Montez-Rath ME, Zolopa AR, Klotman PE, Winkelmayer WC. Trends in the outcomes of end-stage renal disease secondary to human immunodeficiency virus-associated nephropathy. Nephrol Dial Transplant. 2015 Oct; 30(10):1734-40. PMID: 26175146.
      View in: PubMed
    5. Hays T, Ma'ayan A, Clark NR, Tan CM, Teixeira A, Teixeira A, Choi JW, Burdis N, Jung SY, Bajaj AO, O'Malley BW, He JC, Hyink DP, Klotman PE. Proteomics analysis of the non-muscle myosin heavy chain IIa-enriched actin-myosin complex reveals multiple functions within the podocyte. PLoS One. 2014; 9(6):e100660. PMID: 24949636.
      View in: PubMed
    6. Potla U, Ni J, Vadaparampil J, Yang G, Leventhal JS, Campbell KN, Chuang PY, Morozov A, He JC, D'Agati VD, Klotman PE, Kaufman L. Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury. J Clin Invest. 2014 Apr; 124(4):1757-69. PMID: 24642466.
      View in: PubMed
    7. Hutter R, Huang L, Speidl WS, Giannarelli C, Trubin P, Bauriedel G, Klotman ME, Fuster V, Badimon JJ, Klotman PE. Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma. Circulation. 2013 Nov 26; 128(22):2351-63. PMID: 24043300.
      View in: PubMed
    8. Wyatt CM, Schwartz GJ, Owino Ong'or W, Abuya J, Abraham AG, Mboku C, M'mene LB, Koima WJ, Hotta M, Maier P, Klotman PE, Wools-Kaloustian K. Estimating kidney function in HIV-infected adults in Kenya: comparison to a direct measure of glomerular filtration rate by iohexol clearance. PLoS One. 2013; 8(8):e69601. PMID: 23950899.
      View in: PubMed
    9. Gu L, Dai Y, Xu J, Mallipattu S, Kaufman L, Klotman PE, He JC, Chuang PY. Deletion of podocyte STAT3 mitigates the entire spectrum of HIV-1-associated nephropathy. AIDS. 2013 Apr 24; 27(7):1091-8. PMID: 23343908.
      View in: PubMed
    10. Zhong Y, Chen EY, Liu R, Chuang PY, Mallipattu SK, Tan CM, Clark NR, Deng Y, Klotman PE, Ma'ayan A, He JC. Renoprotective effect of combined inhibition of angiotensin-converting enzyme and histone deacetylase. J Am Soc Nephrol. 2013 Apr; 24(5):801-11. PMID: 23559582.
      View in: PubMed
    11. Sharma M, Magenheimer LK, Home T, Tamano KN, Singhal PC, Hyink DP, Klotman PE, Vanden Heuvel GB, Fields TA. Inhibition of Notch pathway attenuates the progression of human immunodeficiency virus-associated nephropathy. Am J Physiol Renal Physiol. 2013 Apr 15; 304(8):F1127-36. PMID: 23389453.
      View in: PubMed
    12. Mallipattu SK, Liu R, Zhong Y, Chen EY, D'Agati V, Kaufman L, Ma'ayan A, Klotman PE, Chuang PY, He JC. Expression of HIV transgene aggravates kidney injury in diabetic mice. Kidney Int. 2013 Apr; 83(4):626-34. PMID: 23325078.
      View in: PubMed
    13. Lipkowitz MS, Freedman BI, Langefeld CD, Comeau ME, Bowden DW, Kao WH, Astor BC, Bottinger EP, Iyengar SK, Klotman PE, Freedman RG, Zhang W, Parekh RS, Choi MJ, Nelson GW, Winkler CA, Kopp JB. Apolipoprotein L1 gene variants associate with hypertension-attributed nephropathy and the rate of kidney function decline in African Americans. Kidney Int. 2013 Jan; 83(1):114-20. PMID: 22832513.
      View in: PubMed
    14. Hays T, D'Agati VD, Garellek JA, Warren T, Trubin ME, Hyink DP, He JC, Klotman PE. Glomerular MYH9 expression is reduced by HIV-1. AIDS. 2012 Apr 24; 26(7):797-803. PMID: 22313957.
      View in: PubMed
    15. Mallipattu SK, Liu R, Zheng F, Narla G, Ma'ayan A, Dikman S, Jain MK, Saleem M, D'Agati V, Klotman P, Chuang PY, He JC. Kruppel-like factor 15 (KLF15) is a key regulator of podocyte differentiation. J Biol Chem. 2012 Jun 01; 287(23):19122-35. PMID: 22493483.
      View in: PubMed
    16. Zhong Y, Wu Y, Liu R, Deng Y, Mallipattu SK, Klotman PE, Chuang PY, He JC. Roflumilast enhances the renal protective effects of retinoids in an HIV-1 transgenic mouse model of rapidly progressive renal failure. Kidney Int. 2012 May; 81(9):856-64. PMID: 22258322.
      View in: PubMed
    17. Papeta N, Kiryluk K, Patel A, Sterken R, Kacak N, Snyder HJ, Imus PH, Mhatre AN, Lawani AK, Julian BA, Wyatt RJ, Novak J, Wyatt CM, Ross MJ, Winston JA, Klotman ME, Cohen DJ, Appel GB, D'Agati VD, Klotman PE, Gharavi AG. APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy. J Am Soc Nephrol. 2011 Nov; 22(11):1991-6. PMID: 21997397.
      View in: PubMed
    18. Wyatt CM, Meliambro K, Klotman PE. Recent progress in HIV-associated nephropathy. Annu Rev Med. 2012; 63:147-59. PMID: 21888512.
      View in: PubMed
    19. Shea JA, Stern DT, Klotman PE, Clayton CP, O'Hara JL, Feldman MD, Griendling KK, Moss M, Straus SE, Jagsi R. Career development of physician scientists: a survey of leaders in academic medicine. Am J Med. 2011 Aug; 124(8):779-87. PMID: 21640329.
      View in: PubMed
    20. Medapalli RK, He JC, Klotman PE. HIV-associated nephropathy: pathogenesis. Curr Opin Nephrol Hypertens. 2011 May; 20(3):306-11. PMID: 21358326.
      View in: PubMed
    21. Stern DT, Podolsky AH, Klotman P. Follow the leader. Educ Health (Abingdon). 2011 Apr; 24(1):615. PMID: 21710426.
      View in: PubMed
    22. Hostetter TH, Kochis DJ, Shaffer RN, Chertow G, Harmon WE, Klotman PE, Powe NR, Sedor JR, Smedberg PC, Watnick S, Winkelmayer WC. World Kidney Day 2011. J Am Soc Nephrol. 2011 Mar; 22(3):397-8. PMID: 21355055.
      View in: PubMed
    23. Chen P, Chen BK, Mosoian A, Hays T, Ross MJ, Klotman PE, Klotman ME. Virological synapses allow HIV-1 uptake and gene expression in renal tubular epithelial cells. J Am Soc Nephrol. 2011 Mar; 22(3):496-507. PMID: 21335514.
      View in: PubMed
    24. Wyatt CM, Hoover DR, Shi Q, Tien PC, Karim R, Cohen MH, Goderre JL, Seaberg EC, Lazar J, Young MA, Klotman PE, Anastos K. Pre-existing albuminuria predicts AIDS and non-AIDS mortality in women initiating antiretroviral therapy. Antivir Ther. 2011; 16(4):591-6. PMID: 21685547.
      View in: PubMed
    25. Ratnam KK, Feng X, Chuang PY, Verma V, Lu TC, Wang J, Jin Y, Farias EF, Napoli JL, Chen N, Kaufman L, Takano T, D'Agati VD, Klotman PE, He JC. Role of the retinoic acid receptor-a in HIV-associated nephropathy. Kidney Int. 2011 Mar; 79(6):624-634. PMID: 21150871.
      View in: PubMed
    26. Wyatt CM, Hoover DR, Shi Q, Seaberg E, Wei C, Tien PC, Karim R, Lazar J, Young MA, Cohen MH, Klotman PE, Anastos K. Microalbuminuria is associated with all-cause and AIDS mortality in women with HIV infection. J Acquir Immune Defic Syndr. 2010 Sep; 55(1):73-7. PMID: 20098331.
      View in: PubMed
    27. Bishop TF, Klotman PE, Vladeck BC, Callahan MA. The future of malpractice reform. Am J Med. 2010 Aug; 123(8):673-4. PMID: 20670716.
      View in: PubMed
    28. Kaufman L, Potla U, Coleman S, Dikiy S, Hata Y, Kurihara H, He JC, D'Agati VD, Klotman PE. Up-regulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosis. J Biol Chem. 2010 Aug 13; 285(33):25677-85. PMID: 20562105.
      View in: PubMed
    29. Mosoian A, Teixeira A, Burns CS, Sander LE, Gusella GL, He C, Blander JM, Klotman P, Klotman ME. Prothymosin-alpha inhibits HIV-1 via Toll-like receptor 4-mediated type I interferon induction. Proc Natl Acad Sci U S A. 2010 Jun 01; 107(22):10178-83. PMID: 20479248.
      View in: PubMed
    30. Snyder A, Alsauskas ZC, Leventhal JS, Rosenstiel PE, Gong P, Chan JJ, Barley K, He JC, Klotman ME, Ross MJ, Klotman PE. HIV-1 viral protein r induces ERK and caspase-8-dependent apoptosis in renal tubular epithelial cells. AIDS. 2010 May 15; 24(8):1107-19. PMID: 20404718.
      View in: PubMed
    31. Kaufman L, Collins SE, Klotman PE. The pathogenesis of HIV-associated nephropathy. Adv Chronic Kidney Dis. 2010 Jan; 17(1):36-43. PMID: 20005487.
      View in: PubMed
    32. Villarroya J, Diaz-Delfin J, Hyink D, Domingo P, Giralt M, Klotman PE, Villarroya F. HIV type-1 transgene expression in mice alters adipose tissue and adipokine levels: towards a rodent model of HIV type-1 lipodystrophy. Antivir Ther. 2010; 15(7):1021-8. PMID: 21041917.
      View in: PubMed
    33. Rosenstiel PE, Chan J, Snyder A, Planelles V, D'Agati VD, Klotman PE, Klotman ME. HIV-1 Vpr activates the DNA damage response in renal tubule epithelial cells. AIDS. 2009 Sep 24; 23(15):2054-6. PMID: 19657269.
      View in: PubMed
    34. Snyder A, Alsauskas Z, Gong P, Rosenstiel PE, Klotman ME, Klotman PE, Ross MJ. FAT10: a novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy. J Virol. 2009 Nov; 83(22):11983-8. PMID: 19726511.
      View in: PubMed
    35. Paragas N, Nickolas TL, Wyatt C, Forster CS, Sise M, Morgello S, Jagla B, Buchen C, Stella P, Sanna-Cherchi S, Carnevali ML, Mattei S, Bovino A, Argentiero L, Magnano A, Devarajan P, Schmidt-Ott KM, Allegri L, Klotman P, D'Agati V, Gharavi AG, Barasch J. Urinary NGAL marks cystic disease in HIV-associated nephropathy. J Am Soc Nephrol. 2009 Aug; 20(8):1687-92. PMID: 19628667.
      View in: PubMed
    36. Feng X, Lu TC, Chuang PY, Fang W, Ratnam K, Xiong H, Ouyang X, Shen Y, Levy DE, Hyink D, Klotman M, D'Agati V, Iyengar R, Klotman PE, He JC. Reduction of Stat3 activity attenuates HIV-induced kidney injury. J Am Soc Nephrol. 2009 Oct; 20(10):2138-46. PMID: 19608706.
      View in: PubMed
    37. Rosenstiel P, Gharavi A, D'Agati V, Klotman P. Transgenic and infectious animal models of HIV-associated nephropathy. J Am Soc Nephrol. 2009 Nov; 20(11):2296-304. PMID: 19497967.
      View in: PubMed
    38. Papeta N, Chan KT, Prakash S, Martino J, Kiryluk K, Ballard D, Bruggeman LA, Frankel R, Zheng Z, Klotman PE, Zhao H, D'Agati VD, Lifton RP, Gharavi AG. Susceptibility loci for murine HIV-associated nephropathy encode trans-regulators of podocyte gene expression. J Clin Invest. 2009 May; 119(5):1178-88. PMID: 19381020.
      View in: PubMed
    39. DuBose TD, Behrens MT, Berns A, Davis C, Goldfarb S, Hostetter T, Klotman P, Linas S, Owens S, Szczech L, Himmelfarb J. The patient-centered medical home and nephrology. J Am Soc Nephrol. 2009 Apr; 20(4):681-2. PMID: 19297553.
      View in: PubMed
    40. Szczech LA, Harmon W, Hostetter TH, Klotman PE, Powe NR, Sedor JR, Smedberg P, Himmelfarb J. World Kidney Day 2009: problems and challenges in the emerging epidemic of kidney disease. J Am Soc Nephrol. 2009 Mar; 20(3):453-5. PMID: 19244576.
      View in: PubMed
    41. Abbadessa G, Accolla R, Aiuti F, Albini A, Aldovini A, Alfano M, Antonelli G, Bartholomew C, Bentwich Z, Bertazzoni U, Berzofsky JA, Biberfeld P, Boeri E, Buonaguro L, Buonaguro FM, Bukrinsky M, Burny A, Caruso A, Cassol S, Chandra P, Ceccherini-Nelli L, Chieco-Bianchi L, Clerici M, Colombini-Hatch S, de Giuli Morghen C, de Maria A, de Rossi A, Dierich M, Della-Favera R, Dolei A, Douek D, Erfle V, Felber B, Fiorentini S, Franchini G, Gershoni JM, Gotch F, Green P, Greene WC, Hall W, Haseltine W, Jacobson S, Kallings LO, Kalyanaraman VS, Katinger H, Khalili K, Klein G, Klein E, Klotman M, Klotman P, Kotler M, Kurth R, Lafeuillade A, La Placa M, Lewis J, Lillo F, Lisziewicz J, Lomonico A, Lopalco L, Lori F, Lusso P, Macchi B, Malim M, Margolis L, Markham PD, McClure M, Miller N, Mingari MC, Moretta L, Noonan D, O'Brien S, Okamoto T, Pal R, Palese P, Panet A, Pantaleo G, Pavlakis G, Pistello M, Plotkin S, Poli G, Pomerantz R, Radaelli A, Robertguroff M, Roederer M, Sarngadharan MG, Schols D, Secchiero P, Shearer G, Siccardi A, Stevenson M, Svoboda J, Tartaglia J, Torelli G, Tornesello ML, Tschachler E, Vaccarezza M, Vallbracht A, van Lunzen J, Varnier O, Vicenzi E, von Melchner H, Witz I, Zagury D, Zagury JF, Zauli G, Zipeto D. Unsung hero Robert C. Gallo. Science. 2009 Jan 09; 323(5911):206-7. PMID: 19131607.
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    42. Chan KT, Papeta N, Martino J, Zheng Z, Frankel RZ, Klotman PE, D'Agati VD, Lifton RP, Gharavi AG. Accelerated development of collapsing glomerulopathy in mice congenic for the HIVAN1 locus. Kidney Int. 2009 Feb; 75(4):366-72. PMID: 19092797.
      View in: PubMed
    43. Wyatt CM, Morgello S, Katz-Malamed R, Wei C, Klotman ME, Klotman PE, D'Agati VD. The spectrum of kidney disease in patients with AIDS in the era of antiretroviral therapy. Kidney Int. 2009 Feb; 75(4):428-34. PMID: 19052538.
      View in: PubMed
    44. Hanss B, Leal-Pinto E, Teixeira A, Tran B, Lee CH, Henderson SC, Klotman PE. Localization of the nucleic acid channel regulatory subunit, cytosolic malate dehydrogenase. J Membr Biol. 2008 Nov-Dec; 226(1-3):1-8. PMID: 19015805.
      View in: PubMed
    45. Wyatt CM, Klotman PE. Kidney disease in HIV infection: introduction. Semin Nephrol. 2008 Nov; 28(6):511-2. PMID: 19013321.
      View in: PubMed
    46. Wyatt CM, Klotman PE, D'Agati VD. HIV-associated nephropathy: clinical presentation, pathology, and epidemiology in the era of antiretroviral therapy. Semin Nephrol. 2008 Nov; 28(6):513-22. PMID: 19013322.
      View in: PubMed
    47. Ratnam KK, He CJ, Klotman P. Nef as a Proliferative Factor for Kidney Epithelial Cells in HIV-Associated Nephropathy. Clin Med Oncol. 2008; 2:539-45. PMID: 21892329.
      View in: PubMed
    48. Wyatt CM, Malvestutto C, Coca SG, Klotman PE, Parikh CR. The impact of hepatitis C virus coinfection on HIV-related kidney disease: a systematic review and meta-analysis. AIDS. 2008 Sep 12; 22(14):1799-807. PMID: 18753863.
      View in: PubMed
    49. Lu TC, Wang Z, Feng X, Chuang P, Fang W, Chen Y, Neves S, Maayan A, Xiong H, Liu Y, Iyengar R, Klotman PE, He JC. Retinoic acid utilizes CREB and USF1 in a transcriptional feed-forward loop in order to stimulate MKP1 expression in human immunodeficiency virus-infected podocytes. Mol Cell Biol. 2008 Sep; 28(18):5785-94. PMID: 18625721.
      View in: PubMed
    50. Rosenstiel PE, Gruosso T, Letourneau AM, Chan JJ, LeBlanc A, Husain M, Najfeld V, Planelles V, D'Agati VD, Klotman ME, Klotman PE. HIV-1 Vpr inhibits cytokinesis in human proximal tubule cells. Kidney Int. 2008 Oct; 74(8):1049-58. PMID: 18614999.
      View in: PubMed
    51. Korgaonkar SN, Feng X, Ross MD, Lu TC, D'Agati V, Iyengar R, Klotman PE, He JC. HIV-1 upregulates VEGF in podocytes. J Am Soc Nephrol. 2008 May; 19(5):877-83. PMID: 18443354.
      View in: PubMed
    52. Sarpel U, Vladeck BC, Divino CM, Klotman PE. Fact and fiction: debunking myths in the US healthcare system. Ann Surg. 2008 Apr; 247(4):563-9. PMID: 18362617.
      View in: PubMed
    53. Lu TC, He JC, Wang ZH, Feng X, Fukumi-Tominaga T, Chen N, Xu J, Iyengar R, Klotman PE. HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting protein. J Biol Chem. 2008 Mar 28; 283(13):8173-82. PMID: 18234668.
      View in: PubMed
    54. Serrano AL, Jardi M, Suelves M, Klotman PE, Munoz-Canoves P. HIV-1 transgenic expression in mice induces selective atrophy of fast-glycolytic skeletal muscle fibers. Front Biosci. 2008 Jan 01; 13:2797-805. PMID: 17981754.
      View in: PubMed
    55. Wyatt CM, Rosenstiel PE, Klotman PE. HIV-associated nephropathy. Contrib Nephrol. 2008; 159:151-61. PMID: 18391591.
      View in: PubMed
    56. Wyatt CM, Winston JA, Malvestutto CD, Fishbein DA, Barash I, Cohen AJ, Klotman ME, Klotman PE. Chronic kidney disease in HIV infection: an urban epidemic. AIDS. 2007 Oct 01; 21(15):2101-3. PMID: 17885301.
      View in: PubMed
    57. Wyatt CM, Klotman PE. HIV-1 and HIV-Associated Nephropathy 25 Years Later. Clin J Am Soc Nephrol. 2007 Jul; 2 Suppl 1:S20-4. PMID: 17699507.
      View in: PubMed
    58. Mosoian A, Teixeira A, Burns CS, Khitrov G, Zhang W, Gusella L, Klotman P, Klotman M. Influence of prothymosin-alpha on HIV-1 target cells. Ann N Y Acad Sci. 2007 Sep; 1112:269-85. PMID: 17600282.
      View in: PubMed
    59. Wyatt CM, Rodriguez-Caprio G, Klotman PE. Efavirenz: innocent bystander or direct nephrotoxin? AIDS. 2007 Jun 19; 21(10):1393. PMID: 17545729.
      View in: PubMed
    60. Lu TC, He JC, Klotman PE. Podocytes in HIV-associated nephropathy. Nephron Clin Pract. 2007; 106(2):c67-71. PMID: 17570932.
      View in: PubMed
    61. Wyatt CM, Klotman PE. HIV-associated nephropathy in the era of antiretroviral therapy. Am J Med. 2007 Jun; 120(6):488-92. PMID: 17524746.
      View in: PubMed
    62. Kaufman L, Yang G, Hayashi K, Ashby JR, Huang L, Ross MJ, Klotman ME, Klotman PE. The homophilic adhesion molecule sidekick-1 contributes to augmented podocyte aggregation in HIV-associated nephropathy. FASEB J. 2007 May; 21(7):1367-75. PMID: 17307840.
      View in: PubMed
    63. Sax PE, Gallant JE, Klotman PE. Renal safety of tenofovir disoproxil fumarate. AIDS Read. 2007 Feb; 17(2):90-2, 99-104, C3. PMID: 17323508.
      View in: PubMed
    64. He JC, Lu TC, Fleet M, Sunamoto M, Husain M, Fang W, Neves S, Chen Y, Shankland S, Iyengar R, Klotman PE. Retinoic acid inhibits HIV-1-induced podocyte proliferation through the cAMP pathway. J Am Soc Nephrol. 2007 Jan; 18(1):93-102. PMID: 17182884.
      View in: PubMed
    65. Shah SN, He CJ, Klotman P. Update on HIV-associated nephropathy. Curr Opin Nephrol Hypertens. 2006 Jul; 15(4):450-5. PMID: 16775461.
      View in: PubMed
    66. Wyatt CM, Klotman PE. HIV-associated nephropathy: a case study in race and genetics. Am J Kidney Dis. 2006 Jun; 47(6):1084-5; author reply 1085. PMID: 16731307.
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    67. Lu TC, He JC, Klotman P. Animal models of HIV-associated nephropathy. Curr Opin Nephrol Hypertens. 2006 May; 15(3):233-7. PMID: 16609288.
      View in: PubMed
    68. Ross MJ, Fan C, Ross MD, Chu TH, Shi Y, Kaufman L, Zhang W, Klotman ME, Klotman PE. HIV-1 infection initiates an inflammatory cascade in human renal tubular epithelial cells. J Acquir Immune Defic Syndr. 2006 May; 42(1):1-11. PMID: 16763488.
      View in: PubMed
    69. Wyatt CM, Klotman PE. Antiretroviral therapy and the kidney: balancing benefit and risk in patients with HIV infection. Expert Opin Drug Saf. 2006 Mar; 5(2):275-87. PMID: 16503748.
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    70. Wyatt CM, Arons RR, Klotman PE, Klotman ME. Acute renal failure in hospitalized patients with HIV: risk factors and impact on in-hospital mortality. AIDS. 2006 Feb 28; 20(4):561-5. PMID: 16470120.
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    71. Zerhouni-Layachi B, Husain M, Ross MJ, Marras D, Sunamoto M, Liu X, Klotman PE, Klotman ME. Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy. AIDS. 2006 Feb 28; 20(4):621-4. PMID: 16470129.
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    72. Ross MJ, Wosnitzer MS, Ross MD, Granelli B, Gusella GL, Husain M, Kaufman L, Vasievich M, D'Agati VD, Wilson PD, Klotman ME, Klotman PE. Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease. J Am Soc Nephrol. 2006 Apr; 17(4):996-1004. PMID: 16495380.
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    73. Husain M, D'Agati VD, He JC, Klotman ME, Klotman PE. HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN. AIDS. 2005 Nov 18; 19(17):1975-80. PMID: 16260903.
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    74. Schwartz EJ, Szczech LA, Ross MJ, Klotman ME, Winston JA, Klotman PE. Highly active antiretroviral therapy and the epidemic of HIV+ end-stage renal disease. J Am Soc Nephrol. 2005 Aug; 16(8):2412-20. PMID: 15987747.
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    75. Gupta SK, Eustace JA, Winston JA, Boydstun II, Ahuja TS, Rodriguez RA, Tashima KT, Roland M, Franceschini N, Palella FJ, Lennox JL, Klotman PE, Nachman SA, Hall SD, Szczech LA. Guidelines for the management of chronic kidney disease in HIV-infected patients: recommendations of the HIV Medicine Association of the Infectious Diseases Society of America. Clin Infect Dis. 2005 Jun 01; 40(11):1559-85. PMID: 15889353.
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    76. Leal-Pinto E, Teixeira A, Tran B, Hanss B, Klotman PE. Presence of the nucleic acid channel in renal brush-border membranes: allosteric modulation by extracellular calcium. Am J Physiol Renal Physiol. 2005 Jul; 289(1):F97-106. PMID: 15727991.
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    77. Hayashi K, Kaufman L, Ross MD, Klotman PE. Definition of the critical domains required for homophilic targeting of mouse sidekick molecules. FASEB J. 2005 Apr; 19(6):614-6. PMID: 15703275.
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    78. He JC, Husain M, Sunamoto M, D'Agati VD, Klotman ME, Iyengar R, Klotman PE. Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways. J Clin Invest. 2004 Sep; 114(5):643-51. PMID: 15343382.
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    79. Szczech LA, Gupta SK, Habash R, Guasch A, Kalayjian R, Appel R, Fields TA, Svetkey LP, Flanagan KH, Klotman PE, Winston JA. The clinical epidemiology and course of the spectrum of renal diseases associated with HIV infection. Kidney Int. 2004 Sep; 66(3):1145-52. PMID: 15327410.
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    80. Kaufman L, Hayashi K, Ross MJ, Ross MD, Klotman PE. Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy. J Am Soc Nephrol. 2004 Jul; 15(7):1721-30. PMID: 15213259.
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    81. Ross MJ, Klotman PE. HIV-associated nephropathy. AIDS. 2004 May 21; 18(8):1089-99. PMID: 15166524.
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    82. Gharavi AG, Ahmad T, Wong RD, Hooshyar R, Vaughn J, Oller S, Frankel RZ, Bruggeman LA, D'Agati VD, Klotman PE, Lifton RP. Mapping a locus for susceptibility to HIV-1-associated nephropathy to mouse chromosome 3. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2488-93. PMID: 14983036.
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    83. Richardson MW, Hostalek L, Dobson M, Hu J, Shippy R, Siwkowski A, Marmur JD, Khalili K, Klotman PE, Hampel A, Rappaport J. Design, targeting, and initial screening of sTRSV-derived hairpin ribozymes for optimum helix 1 length and catalytic efficiency in vitro. Methods Mol Biol. 2004; 252:339-58. PMID: 15017062.
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    84. Sunamoto M, Husain M, He JC, Schwartz EJ, Klotman PE. Critical role for Nef in HIV-1-induced podocyte dedifferentiation. Kidney Int. 2003 Nov; 64(5):1695-701. PMID: 14531802.
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    85. Ross MD, Bruggeman LA, Hanss B, Sunamoto M, Marras D, Klotman ME, Klotman PE. Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathy. J Biol Chem. 2003 Aug 29; 278(35):33248-55. PMID: 12796502.
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    86. Herman ES, Klotman PE. HIV-associated nephropathy: Epidemiology, pathogenesis, and treatment. Semin Nephrol. 2003 Mar; 23(2):200-8. PMID: 12704580.
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    87. Ross MJ, Klotman PE. Recent progress in HIV-associated nephropathy. J Am Soc Nephrol. 2002 Dec; 13(12):2997-3004. PMID: 12444220.
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    88. Cusumano AM, Bodkin NL, Hansen BC, Iotti R, Owens J, Klotman PE, Kopp JB. Glomerular hypertrophy is associated with hyperinsulinemia and precedes overt diabetes in aging rhesus monkeys. Am J Kidney Dis. 2002 Nov; 40(5):1075-85. PMID: 12407654.
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    89. Husain M, Gusella GL, Klotman ME, Gelman IH, Ross MD, Schwartz EJ, Cara A, Klotman PE. HIV-1 Nef induces proliferation and anchorage-independent growth in podocytes. J Am Soc Nephrol. 2002 Jul; 13(7):1806-15. PMID: 12089376.
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    90. Coller BS, Klotman P, Smith LG. Professing and living the oath: teaching medicine as a profession. Am J Med. 2002 Jun 15; 112(9):744-8. PMID: 12079723.
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    91. Schwartz EJ, Fierer DS, Neumann AU, Keller MJ, Parkas V, Zhang DY, Klotman ME, Winston JA, Klotman PE. HIV-1 dynamics in haemodialysis patients. AIDS. 2002 Jun 14; 16(9):1301-3. PMID: 12045502.
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    92. Klotman P, Klotman M. Editorial comment: renal insufficiency in HIV-infected patients may not always be HIVAN. AIDS Read. 2002 Jun; 12(6):273. PMID: 12138882.
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    93. Marras D, Bruggeman LA, Gao F, Tanji N, Mansukhani MM, Cara A, Ross MD, Gusella GL, Benson G, D'Agati VD, Hahn BH, Klotman ME, Klotman PE. Replication and compartmentalization of HIV-1 in kidney epithelium of patients with HIV-associated nephropathy. Nat Med. 2002 May; 8(5):522-6. PMID: 11984599.
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    94. Schwartz EJ, Neumann AU, Teixeira AV, Bruggeman LA, Rappaport J, Perelson AS, Klotman PE. Effect of target cell availability on HIV-1 production in vitro. AIDS. 2002 Feb 15; 16(3):341-5. PMID: 11834944.
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    95. Gusella GL, Fedorova E, Hanss B, Marras D, Klotman ME, Klotman PE. Lentiviral gene transduction of kidney. Hum Gene Ther. 2002 Feb 10; 13(3):407-14. PMID: 11860707.
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    96. Hanss B, Leal-Pinto E, Teixeira A, Christian RE, Shabanowitz J, Hunt DF, Klotman PE. Cytosolic malate dehydrogenase confers selectivity of the nucleic acid-conducting channel. Proc Natl Acad Sci U S A. 2002 Feb 05; 99(3):1707-12. PMID: 11805283.
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    97. Woo S, Klotman P. Gene therapy and renal disease. Introduction. Kidney Int. 2002 Jan; 61(1 Suppl):S1-2. PMID: 11841604.
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    98. Gusella GL, Fedorova E, Marras D, Klotman PE, Klotman ME. In vivo gene transfer to kidney by lentiviral vector. Kidney Int. 2002 Jan; 61(1 Suppl):S32-6. PMID: 11841609.
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    99. Stern AS, Klotman ME, Ioannou YA, Burrow CR, Wilson PD, Klotman PE, Lipkowitz MS. Polarity of alpha-galactosidase A uptake by renal tubule cells. Kidney Int. 2002 Jan; 61(1 Suppl):S52-5. PMID: 11841613.
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