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NINO CARLO RAINUSSO

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Oncology
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    Collapse Biography 
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    2007St.Baldrick's Foundation Fellowship, St.Baldrick's Foundation
    2009Young Investigator Award, American Society of Clinical Oncology
    2013St.Baldrick's Scholar Award, St.Baldrick's Foundation

    Collapse Overview 
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    I am physician scientist, who is interested in the role of cancer stem cells (CSCs) in tumorigenesis and chemotherapy resistance in pediatric sarcomas. I have conducted several studies aimed to characterize CSCs in pediatric bone tumors. For the past 5 years, I have been a member of the Osteosarcoma Research Program and the Musculoskeletal Tumor Clinic at Texas Children’s Cancer Center. I have successfully developed a patient derived tumor xenograft mouse model for pediatric sarcomas using tumor specimens obtained from patients treated in our institution.
    As a clinician, I’m also interested in the evaluation and prevention of the cardiotoxic effects caused by chemotherapy

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Nomura M, Rainusso N, Lee YC, Dawson B, Coarfa C, Han R, Larson JL, Shuck R, Kurenbekova L, Yustein JT. Tegavivint and the ß-catenin/ALDH Axis in Chemotherapy-Resistant and Metastatic Osteosarcoma. J Natl Cancer Inst. 2019 Feb 21. PMID: 30793158.
      View in: PubMed
    2. Rainusso N, Seghers V, Egler R, Hicks J, Russell HV. Neuroblastoma of the Bone and Bone Marrow Without an Apparent Primary Site: Report of 4 Cases With Long-term Follow-up. Pediatr Dev Pathol. 2019 Jul-Aug; 22(4):329-333. PMID: 30600764.
      View in: PubMed
    3. Rainusso N, Cleveland H, Hernandez JA, Quintanilla NM, Hicks J, Vasudevan S, Marco RAW, Allen-Rhoades W, Wang LL, Yustein JT. Generation of patient-derived tumor xenografts from percutaneous tumor biopsies in children with bone sarcomas. Pediatr Blood Cancer. 2019 Apr; 66(4):e27579. PMID: 30548185.
      View in: PubMed
    4. Allen-Rhoades W, Whittle SB, Rainusso N. Pediatric Solid Tumors in Children and Adolescents: An Overview. Pediatr Rev. 2018 Sep; 39(9):444-453. PMID: 30171055.
      View in: PubMed
    5. Fuja DG, Rainusso NC, Shuck RL, Kurenbekova L, Donehower LA, Yustein JT. Transglutaminase-2 promotes metastatic and stem-like phenotypes in osteosarcoma. Am J Cancer Res. 2018; 8(9):1752-1763. PMID: 30323968.
      View in: PubMed
    6. Allen-Rhoades W, Whittle SB, Rainusso N. Pediatric Solid Tumors of Infancy: An Overview. Pediatr Rev. 2018 Feb; 39(2):57-67. PMID: 29437125.
      View in: PubMed
    7. Byrd TT, Fousek K, Pignata A, Szot C, Samaha H, Seaman S, Dobrolecki L, Salsman VS, Oo HZ, Bielamowicz K, Landi D, Rainusso N, Hicks J, Powell S, Baker ML, Wels WS, Koch J, Sorensen PH, Deneen B, Ellis MJ, Lewis MT, Hegde M, Fletcher BS, St Croix B, Ahmed N. TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer. Cancer Res. 2018 01 15; 78(2):489-500. PMID: 29183891.
      View in: PubMed
    8. Mohan AC, Venkatramani R, Okcu MF, Nuchtern JG, Vasudevan SA, Mahajan A, Rainusso NC, Allen-Rhoades W, Chintagumpala M, Paulino AC. Local therapy to distant metastatic sites in stage IV rhabdomyosarcoma. Pediatr Blood Cancer. 2018 Feb; 65(2). PMID: 29049857.
      View in: PubMed
    9. Dasgupta A, Trucco M, Rainusso N, Bernardi RJ, Shuck R, Kurenbekova L, Loeb DM, Yustein JT. Metabolic modulation of Ewing sarcoma cells inhibits tumor growth and stem cell properties. Oncotarget. 2017 Sep 29; 8(44):77292-77308. PMID: 29100387.
      View in: PubMed
    10. Rao PH, Zhao S, Zhao YJ, Yu A, Rainusso N, Trucco M, Allen-Rhoades W, Satterfield L, Fuja D, Borra VJ, Man TK, Donehower LA, Yustein JT. Coamplification of Myc/Pvt1 and homozygous deletion of Nlrp1 locus are frequent genetics changes in mouse osteosarcoma. Genes Chromosomes Cancer. 2015 Dec; 54(12):796-808. PMID: 26355645.
      View in: PubMed
    11. Ahmed N, Brawley VS, Hegde M, Robertson C, Ghazi A, Gerken C, Liu E, Dakhova O, Ashoori A, Corder A, Gray T, Wu MF, Liu H, Hicks J, Rainusso N, Dotti G, Mei Z, Grilley B, Gee A, Rooney CM, Brenner MK, Heslop HE, Wels WS, Wang LL, Anderson P, Gottschalk S. Human Epidermal Growth Factor Receptor 2 (HER2) -Specific Chimeric Antigen Receptor-Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma. J Clin Oncol. 2015 May 20; 33(15):1688-96. PMID: 25800760.
      View in: PubMed
    12. Allen-Rhoades W, Kurenbekova L, Satterfield L, Parikh N, Fuja D, Shuck RL, Rainusso N, Trucco M, Barkauskas DA, Jo E, Ahern C, Hilsenbeck S, Donehower LA, Yustein JT. Cross-species identification of a plasma microRNA signature for detection, therapeutic monitoring, and prognosis in osteosarcoma. Cancer Med. 2015 Jul; 4(7):977-88. PMID: 25784290.
      View in: PubMed
    13. Rainusso N, Wang LL, Yustein JT. The adolescent and young adult with cancer: state of the art -- bone tumors. Curr Oncol Rep. 2013 Aug; 15(4):296-307. PMID: 23690089.
      View in: PubMed
    14. Chow KK, Naik S, Kakarla S, Brawley VS, Shaffer DR, Yi Z, Rainusso N, Wu MF, Liu H, Kew Y, Grossman RG, Powell S, Lee D, Ahmed N, Gottschalk S. T cells redirected to EphA2 for the immunotherapy of glioblastoma. Mol Ther. 2013 Mar; 21(3):629-37. PMID: 23070117.
      View in: PubMed
    15. Rainusso N, Brawley VS, Ghazi A, Hicks MJ, Gottschalk S, Rosen JM, Ahmed N. Immunotherapy targeting HER2 with genetically modified T cells eliminates tumor-initiating cells in osteosarcoma. Cancer Gene Ther. 2012 Mar; 19(3):212-7. PMID: 22173710.
      View in: PubMed
    16. Rainusso N, Man TK, Lau CC, Hicks J, Shen JJ, Yu A, Wang LL, Rosen JM. Identification and gene expression profiling of tumor-initiating cells isolated from human osteosarcoma cell lines in an orthotopic mouse model. Cancer Biol Ther. 2011 Aug 15; 12(4):278-87. PMID: 21617384.
      View in: PubMed
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