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NIKOLAOS GEORGI FRANGOGIANNIS

TitleAdjunct Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
DivisionMedicine-Cardiovascular Science
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    R01HL076246     (FRANGOGIANNIS, NIKOLAOS G)Apr 1, 2004 - Jan 31, 2019
    NIH/NHLBI
    Chemokines in Healing Myocardial Infarction
    Role: Principal Investigator

    R01HL085440     (FRANGOGIANNIS, NIKOLAOS G)Jun 1, 2006 - May 31, 2021
    NIH/NHLBI
    Resolution of inflammation in healing myocardial infarcts
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Frangogiannis NG. How do endosomal Toll-like receptors sense and extend ischaemic myocardial injury? Cardiovasc Res. 2019 Oct 01; 115(12):1687-1689. PMID: 31099398.
      View in: PubMed
    2. Frangogiannis NG. S100A8/A9 as a therapeutic target in myocardial infarction: cellular mechanisms, molecular interactions, and translational challenges. Eur Heart J. 2019 Aug 21; 40(32):2724-2726. PMID: 31334753.
      View in: PubMed
    3. Hanna A, Frangogiannis NG. The cell biological basis for primary unloading in acute myocardial infarction. Int J Cardiol. 2019 Oct 15; 293:45-47. PMID: 31296394.
      View in: PubMed
    4. Humeres C, Frangogiannis NG. Fibroblasts in the Infarcted, Remodeling, and Failing Heart. JACC Basic Transl Sci. 2019 Jun; 4(3):449-467. PMID: 31312768.
      View in: PubMed
    5. Frangogiannis NG. The Extracellular Matrix in Ischemic and Nonischemic Heart Failure. Circ Res. 2019 Jun 21; 125(1):117-146. PMID: 31219741.
      View in: PubMed
    6. Andreadou I, Cabrera-Fuentes HA, Devaux Y, Frangogiannis NG, Frantz S, Guzik T, Liehn EA, Gomes CPC, Schulz R, Hausenloy DJ. Immune cells as targets for cardioprotection: new players and novel therapeutic opportunities. Cardiovasc Res. 2019 Jun 01; 115(7):1117-1130. PMID: 30825305.
      View in: PubMed
    7. Chen B, Huang S, Su Y, Wu YJ, Hanna A, Brickshawana A, Graff J, Frangogiannis NG. Macrophage Smad3 Protects the Infarcted Heart, Stimulating Phagocytosis and Regulating Inflammation. Circ Res. 2019 Jun 21; 125(1):55-70. PMID: 31092129.
      View in: PubMed
    8. Frangogiannis NG. Can Myocardial Fibrosis Be Reversed? J Am Coll Cardiol. 2019 May 14; 73(18):2283-2285. PMID: 31072571.
      View in: PubMed
    9. Huang S, Chen B, Su Y, Alex L, Humeres C, Shinde AV, Conway SJ, Frangogiannis NG. Distinct roles of myofibroblast-specific Smad2 and Smad3 signaling in repair and remodeling of the infarcted heart. J Mol Cell Cardiol. 2019 Jul; 132:84-97. PMID: 31085202.
      View in: PubMed
    10. Russo I, Cavalera M, Huang S, Su Y, Hanna A, Chen B, Shinde AV, Conway SJ, Graff J, Frangogiannis NG. Protective Effects of Activated Myofibroblasts in the Pressure-Overloaded Myocardium Are Mediated Through Smad-Dependent Activation of a Matrix-Preserving Program. Circ Res. 2019 Apr 12; 124(8):1214-1227. PMID: 30686120.
      View in: PubMed
    11. Chen B, Brickshawana A, Frangogiannis NG. The Functional Heterogeneity of Resident Cardiac Macrophages in Myocardial InjuryCCR2+ Cells Promote Inflammation, Whereas CCR2- Cells Protect. Circ Res. 2019 Jan 18; 124(2):183-185. PMID: 30653429.
      View in: PubMed
    12. Frangogiannis NG. Protean Functions and Phenotypic Plasticity of Regulatory T Cells in Chronic Ischemic Heart Failure. Circulation. 2019 01 08; 139(2):222-225. PMID: 30615501.
      View in: PubMed
    13. Chen B, Huang S, Frangogiannis NG. Aging, cardiac repair and Smad3. Aging (Albany NY). 2018 09 20; 10(9):2230-2232. PMID: 30243021.
      View in: PubMed
    14. Frangogiannis NG. Cardiac fibrosis: Cell biological mechanisms, molecular pathways and therapeutic opportunities. Mol Aspects Med. 2019 02; 65:70-99. PMID: 30056242.
      View in: PubMed
    15. Alex L, Russo I, Holoborodko V, Frangogiannis NG. Characterization of a mouse model of obesity-related fibrotic cardiomyopathy that recapitulates features of human heart failure with preserved ejection fraction. Am J Physiol Heart Circ Physiol. 2018 10 01; 315(4):H934-H949. PMID: 30004258.
      View in: PubMed
    16. Frangogiannis NG. Targeting mitochondrial calcium transport in myocardial infarction. Hellenic J Cardiol. 2018 Jul - Aug; 59(4):223-225. PMID: 29940221.
      View in: PubMed
    17. Chen B, Frangogiannis NG. The Role of Macrophages in Nonischemic Heart Failure. JACC Basic Transl Sci. 2018 Apr; 3(2):245-248. PMID: 30062210.
      View in: PubMed
    18. Frangogiannis NG. Galectin-3 in the fibrotic response: Cellular targets and molecular mechanisms. Int J Cardiol. 2018 05 01; 258:226-227. PMID: 29544937.
      View in: PubMed
    19. Huang S, Frangogiannis NG. Anti-inflammatory therapies in myocardial infarction: failures, hopes and challenges. Br J Pharmacol. 2018 05; 175(9):1377-1400. PMID: 29394499.
      View in: PubMed
    20. Kirk JA, Frangogiannis NG. Galectin-3 in the pathogenesis of heart failure: a causative mediator or simply a biomarker? Am J Physiol Heart Circ Physiol. 2018 06 01; 314(6):H1256-H1258. PMID: 29498533.
      View in: PubMed
    21. Shinde AV, Su Y, Palanski BA, Fujikura K, Garcia MJ, Frangogiannis NG. Pharmacologic inhibition of the enzymatic effects of tissue transglutaminase reduces cardiac fibrosis and attenuates cardiomyocyte hypertrophy following pressure overload. J Mol Cell Cardiol. 2018 04; 117:36-48. PMID: 29481819.
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    22. Alex L, Frangogiannis NG. The Cellular Origin of Activated Fibroblasts in the Infarcted and Remodeling Myocardium. Circ Res. 2018 02 16; 122(4):540-542. PMID: 29449358.
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    23. Frangogiannis NG. Cell therapy for peripheral artery disease. Curr Opin Pharmacol. 2018 04; 39:27-34. PMID: 29452987.
      View in: PubMed
    24. Lindsey ML, Bolli R, Canty JM, Du XJ, Frangogiannis NG, Frantz S, Gourdie RG, Holmes JW, Jones SP, Kloner RA, Lefer DJ, Liao R, Murphy E, Ping P, Przyklenk K, Recchia FA, Schwartz Longacre L, Ripplinger CM, Van Eyk JE, Heusch G. Guidelines for experimental models of myocardial ischemia and infarction. Am J Physiol Heart Circ Physiol. 2018 04 01; 314(4):H812-H838. PMID: 29351451.
      View in: PubMed
    25. Shinde AV, Frangogiannis NG. Tissue transglutaminase in the pathogenesis of heart failure. Cell Death Differ. 2018 03; 25(3):453-456. PMID: 29238072.
      View in: PubMed
    26. Frangogiannis NG. Cell biological mechanisms in regulation of the post-infarction inflammatory response. Curr Opin Physiol. 2018 Feb; 1:7-13. PMID: 29552674.
      View in: PubMed
    27. Kong P, Shinde AV, Su Y, Russo I, Chen B, Saxena A, Conway SJ, Graff JM, Frangogiannis NG. Opposing Actions of Fibroblast and Cardiomyocyte Smad3 Signaling in the Infarcted Myocardium. Circulation. 2018 02 13; 137(7):707-724. PMID: 29229611.
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    28. Frangogiannis NG. Fibroblasts and the extracellular matrix in right ventricular disease. Cardiovasc Res. 2017 Oct 01; 113(12):1453-1464. PMID: 28957531.
      View in: PubMed
    29. Wang Y, Wu B, Lu P, Zhang D, Wu B, Varshney S, Del Monte-Nieto G, Zhuang Z, Charafeddine R, Kramer AH, Sibinga NE, Frangogiannis NG, Kitsis RN, Adams RH, Alitalo K, Sharp DJ, Harvey RP, Stanley P, Zhou B. Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1. Nat Commun. 2017 09 18; 8(1):578. PMID: 28924218.
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    30. Shinde AV, Dobaczewski M, de Haan JJ, Saxena A, Lee KK, Xia Y, Chen W, Su Y, Hanif W, Kaur Madahar I, Paulino VM, Melino G, Frangogiannis NG. Tissue transglutaminase induction in the pressure-overloaded myocardium regulates matrix remodelling. Cardiovasc Res. 2017 Jul 01; 113(8):892-905. PMID: 28371893.
      View in: PubMed
    31. Hanif W, Alex L, Su Y, Shinde AV, Russo I, Li N, Frangogiannis NG. Left atrial remodeling, hypertrophy, and fibrosis in mouse models of heart failure. Cardiovasc Pathol. 2017 Sep - Oct; 30:27-37. PMID: 28759817.
      View in: PubMed
    32. Frangogiannis NG. The extracellular matrix in myocardial injury, repair, and remodeling. J Clin Invest. 2017 May 01; 127(5):1600-1612. PMID: 28459429.
      View in: PubMed
    33. Frangogiannis NG. Editor's Choice- Activation of the innate immune system in the pathogenesis of acute heart failure. Eur Heart J Acute Cardiovasc Care. 2018 Jun; 7(4):358-361. PMID: 28452231.
      View in: PubMed
    34. Shinde AV, Frangogiannis NG. Mechanisms of Fibroblast Activation in the Remodeling Myocardium. Curr Pathobiol Rep. 2017 Jun; 5(2):145-152. PMID: 29057165.
      View in: PubMed
    35. Frangogiannis NG. The role of transforming growth factor (TGF)-ß in the infarcted myocardium. J Thorac Dis. 2017 Mar; 9(Suppl 1):S52-S63. PMID: 28446968.
      View in: PubMed
    36. Chen B, Frangogiannis NG. Immune cells in repair of the infarcted myocardium. Microcirculation. 2017 01; 24(1). PMID: 27542099.
      View in: PubMed
    37. Shinde AV, Humeres C, Frangogiannis NG. The role of a-smooth muscle actin in fibroblast-mediated matrix contraction and remodeling. Biochim Biophys Acta Mol Basis Dis. 2017 01; 1863(1):298-309. PMID: 27825850.
      View in: PubMed
    38. Spinale FG, Frangogiannis NG, Hinz B, Holmes JW, Kassiri Z, Lindsey ML. Crossing Into the Next Frontier of Cardiac Extracellular Matrix Research. Circ Res. 2016 10 28; 119(10):1040-1045. PMID: 27789578.
      View in: PubMed
    39. Frangogiannis NG. The Functional Pluralism of Fibroblasts in the Infarcted Myocardium. Circ Res. 2016 10 28; 119(10):1049-1051. PMID: 27789580.
      View in: PubMed
    40. Chen B, Frangogiannis NG. Macrophages in the Remodeling Failing Heart. Circ Res. 2016 09 16; 119(7):776-8. PMID: 27635078.
      View in: PubMed
    41. Frunza O, Russo I, Shinde AV, Su Y, Frangogiannis NG. Authors' Reply. Am J Pathol. 2016 Aug; 186(8):2234-2235. PMID: 27461365.
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    42. Prabhu SD, Frangogiannis NG. The Biological Basis for Cardiac Repair After Myocardial Infarction: From Inflammation to Fibrosis. Circ Res. 2016 06 24; 119(1):91-112. PMID: 27340270.
      View in: PubMed
    43. Frunza O, Russo I, Saxena A, Shinde AV, Humeres C, Hanif W, Rai V, Su Y, Frangogiannis NG. Myocardial Galectin-3 Expression Is Associated with Remodeling of the Pressure-Overloaded Heart and May Delay the Hypertrophic Response without Affecting Survival, Dysfunction, and Cardiac Fibrosis. Am J Pathol. 2016 05; 186(5):1114-27. PMID: 26948424.
      View in: PubMed
    44. Frangogiannis NG. Fibroblast-Extracellular Matrix Interactions in Tissue Fibrosis. Curr Pathobiol Rep. 2016 Mar; 4(1):11-18. PMID: 27171595.
      View in: PubMed
    45. Russo I, Frangogiannis NG. Diabetes-associated cardiac fibrosis: Cellular effectors, molecular mechanisms and therapeutic opportunities. J Mol Cell Cardiol. 2016 Jan; 90:84-93. PMID: 26705059.
      View in: PubMed
    46. Saxena A, Shinde AV, Haque Z, Wu YJ, Chen W, Su Y, Frangogiannis NG. The role of Interleukin Receptor Associated Kinase (IRAK)-M in regulation of myofibroblast phenotype in vitro, and in an experimental model of non-reperfused myocardial infarction. J Mol Cell Cardiol. 2015 Dec; 89(Pt B):223-31. PMID: 26542797.
      View in: PubMed
    47. Frangogiannis NG. Pathophysiology of Myocardial Infarction. Compr Physiol. 2015 Sep 20; 5(4):1841-75. PMID: 26426469.
      View in: PubMed
    48. Frangogiannis NG. Emerging roles for macrophages in cardiac injury: cytoprotection, repair, and regeneration. J Clin Invest. 2015 Aug 03; 125(8):2927-30. PMID: 26214519.
      View in: PubMed
    49. Saxena A, Russo I, Frangogiannis NG. Inflammation as a therapeutic target in myocardial infarction: learning from past failures to meet future challenges. Transl Res. 2016 Jan; 167(1):152-66. PMID: 26241027.
      View in: PubMed
    50. Shinde AV, Frangogiannis NG. Mediators secreted by myeloid cells may protect and repair the infarcted myocardium. Circ Res. 2015 Jun 19; 117(1):10-2. PMID: 26089362.
      View in: PubMed
    51. Frangogiannis NG. The reparative function of cardiomyocytes in the infarcted myocardium. Cell Metab. 2015 Jun 02; 21(6):797-8. PMID: 26039445.
      View in: PubMed
    52. Biernacka A, Cavalera M, Wang J, Russo I, Shinde A, Kong P, Gonzalez-Quesada C, Rai V, Dobaczewski M, Lee DW, Wang XF, Frangogiannis NG. Smad3 Signaling Promotes Fibrosis While Preserving Cardiac and Aortic Geometry in Obese Diabetic Mice. Circ Heart Fail. 2015 Jul; 8(4):788-98. PMID: 25985794.
      View in: PubMed
    53. Frangogiannis NG. Inflammation in cardiac injury, repair and regeneration. Curr Opin Cardiol. 2015 May; 30(3):240-5. PMID: 25807226.
      View in: PubMed
    54. Frangogiannis NG. Interleukin-1 in cardiac injury, repair, and remodeling: pathophysiologic and translational concepts. Discoveries (Craiova). 2015 Jan-Mar; 3(1). PMID: 26273700.
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    55. Frangogiannis NG. Targeting the transforming growth factor (TGF)-ß cascade in the remodeling heart: benefits and perils. J Mol Cell Cardiol. 2014 Nov; 76:169-71. PMID: 25218305.
      View in: PubMed
    56. Saxena A, Dobaczewski M, Rai V, Haque Z, Chen W, Li N, Frangogiannis NG. Regulatory T cells are recruited in the infarcted mouse myocardium and may modulate fibroblast phenotype and function. Am J Physiol Heart Circ Physiol. 2014 Oct 15; 307(8):H1233-42. PMID: 25128167.
      View in: PubMed
    57. Saxena A, Bujak M, Frunza O, Dobaczewski M, Gonzalez-Quesada C, Lu B, Gerard C, Frangogiannis NG. CXCR3-independent actions of the CXC chemokine CXCL10 in the infarcted myocardium and in isolated cardiac fibroblasts are mediated through proteoglycans. Cardiovasc Res. 2014 Jul 15; 103(2):217-27. PMID: 24891401.
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    58. Cavalera M, Wang J, Frangogiannis NG. Obesity, metabolic dysfunction, and cardiac fibrosis: pathophysiological pathways, molecular mechanisms, and therapeutic opportunities. Transl Res. 2014 Oct; 164(4):323-35. PMID: 24880146.
      View in: PubMed
    59. Frangogiannis NG. The inflammatory response in myocardial injury, repair, and remodelling. Nat Rev Cardiol. 2014 May; 11(5):255-65. PMID: 24663091.
      View in: PubMed
    60. Frangogiannis NG. The immune system and the remodeling infarcted heart: cell biological insights and therapeutic opportunities. J Cardiovasc Pharmacol. 2014 Mar; 63(3):185-95. PMID: 24072174.
      View in: PubMed
    61. Rienks M, Papageorgiou AP, Frangogiannis NG, Heymans S. Myocardial extracellular matrix: an ever-changing and diverse entity. Circ Res. 2014 Feb 28; 114(5):872-88. PMID: 24577967.
      View in: PubMed
    62. Frangogiannis NG. Contribution of extramedullary organs in myocardial inflammation and remodeling: does the spleen cause cardiac melancholy? Circ Res. 2014 Jan 17; 114(2):230-2. PMID: 24436423.
      View in: PubMed
    63. Cavalera M, Frangogiannis NG. Targeting the chemokines in cardiac repair. Curr Pharm Des. 2014; 20(12):1971-9. PMID: 23844733.
      View in: PubMed
    64. Shinde AV, Frangogiannis NG. Fibroblasts in myocardial infarction: a role in inflammation and repair. J Mol Cell Cardiol. 2014 May; 70:74-82. PMID: 24321195.
      View in: PubMed
    65. Frangogiannis NG. MicroRNAs and endothelial function: many challenges and early hopes for clinical applications. J Am Coll Cardiol. 2014 Apr 29; 63(16):1695-6. PMID: 24291271.
      View in: PubMed
    66. Kong P, Cavalera M, Frangogiannis NG. The role of thrombospondin (TSP)-1 in obesity and diabetes. Adipocyte. 2014 Jan 01; 3(1):81-4. PMID: 24575376.
      View in: PubMed
    67. Gonzalez-Quesada C, Cavalera M, Biernacka A, Kong P, Lee DW, Saxena A, Frunza O, Dobaczewski M, Shinde A, Frangogiannis NG. Thrombospondin-1 induction in the diabetic myocardium stabilizes the cardiac matrix in addition to promoting vascular rarefaction through angiopoietin-2 upregulation. Circ Res. 2013 Dec 06; 113(12):1331-44. PMID: 24081879.
      View in: PubMed
    68. Saxena A, Chen W, Su Y, Rai V, Uche OU, Li N, Frangogiannis NG. IL-1 induces proinflammatory leukocyte infiltration and regulates fibroblast phenotype in the infarcted myocardium. J Immunol. 2013 Nov 01; 191(9):4838-48. PMID: 24078695.
      View in: PubMed
    69. Kong P, Christia P, Saxena A, Su Y, Frangogiannis NG. Lack of specificity of fibroblast-specific protein 1 in cardiac remodeling and fibrosis. Am J Physiol Heart Circ Physiol. 2013 Nov 01; 305(9):H1363-72. PMID: 23997102.
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    70. Christia P, Frangogiannis NG. Targeting inflammatory pathways in myocardial infarction. Eur J Clin Invest. 2013 Sep; 43(9):986-95. PMID: 23772948.
      View in: PubMed
    71. Kong P, Gonzalez-Quesada C, Li N, Cavalera M, Lee DW, Frangogiannis NG. Thrombospondin-1 regulates adiposity and metabolic dysfunction in diet-induced obesity enhancing adipose inflammation and stimulating adipocyte proliferation. Am J Physiol Endocrinol Metab. 2013 Aug 01; 305(3):E439-50. PMID: 23757408.
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    72. Christia P, Bujak M, Gonzalez-Quesada C, Chen W, Dobaczewski M, Reddy A, Frangogiannis NG. Systematic characterization of myocardial inflammation, repair, and remodeling in a mouse model of reperfused myocardial infarction. J Histochem Cytochem. 2013 Aug; 61(8):555-70. PMID: 23714783.
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    73. Kong P, Christia P, Frangogiannis NG. The pathogenesis of cardiac fibrosis. Cell Mol Life Sci. 2014 Feb; 71(4):549-74. PMID: 23649149.
      View in: PubMed
    74. Chen W, Saxena A, Li N, Sun J, Gupta A, Lee DW, Tian Q, Dobaczewski M, Frangogiannis NG. Endogenous IRAK-M attenuates postinfarction remodeling through effects on macrophages and fibroblasts. Arterioscler Thromb Vasc Biol. 2012 Nov; 32(11):2598-608. PMID: 22995519.
      View in: PubMed
    75. Chen W, Frangogiannis NG. Fibroblasts in post-infarction inflammation and cardiac repair. Biochim Biophys Acta. 2013 Apr; 1833(4):945-53. PMID: 22982064.
      View in: PubMed
    76. Dobaczewski M, de Haan JJ, Frangogiannis NG. The extracellular matrix modulates fibroblast phenotype and function in the infarcted myocardium. J Cardiovasc Transl Res. 2012 Dec; 5(6):837-47. PMID: 22956156.
      View in: PubMed
    77. Frangogiannis NG. Monomeric C-reactive protein and inflammatory injury in myocardial infarction. Cardiovasc Res. 2012 Oct 01; 96(1):4-6. PMID: 22871589.
      View in: PubMed
    78. Frangogiannis NG. Matricellular proteins in cardiac adaptation and disease. Physiol Rev. 2012 Apr; 92(2):635-88. PMID: 22535894.
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    79. Frangogiannis NG. Biomarkers: hopes and challenges in the path from discovery to clinical practice. Transl Res. 2012 Apr; 159(4):197-204. PMID: 22424424.
      View in: PubMed
    80. Frangogiannis NG. Regulation of the inflammatory response in cardiac repair. Circ Res. 2012 Jan 06; 110(1):159-73. PMID: 22223212.
      View in: PubMed
    81. Frangogiannis NG. The stromal cell-derived factor-1/CXCR4 axis in cardiac injury and repair. J Am Coll Cardiol. 2011 Nov 29; 58(23):2424-6. PMID: 22115650.
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    82. Xia Y, Dobaczewski M, Gonzalez-Quesada C, Chen W, Biernacka A, Li N, Lee DW, Frangogiannis NG. Endogenous thrombospondin 1 protects the pressure-overloaded myocardium by modulating fibroblast phenotype and matrix metabolism. Hypertension. 2011 Nov; 58(5):902-11. PMID: 21947471.
      View in: PubMed
    83. Biernacka A, Dobaczewski M, Frangogiannis NG. TGF-ß signaling in fibrosis. Growth Factors. 2011 Oct; 29(5):196-202. PMID: 21740331.
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    84. Biernacka A, Frangogiannis NG. Aging and Cardiac Fibrosis. Aging Dis. 2011 Apr; 2(2):158-173. PMID: 21837283.
      View in: PubMed
    85. Frangogiannis NG. Stromal cell-derived factor-1-mediated angiogenesis for peripheral arterial disease: ready for prime time? Circulation. 2011 Mar 29; 123(12):1267-9. PMID: 21403099.
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    86. Dobaczewski M, Frangogiannis NG. The cellular specificity of leptin-mediated actions in the infarcted heart. Cardiovasc Res. 2011 Jan 01; 89(1):9-11. PMID: 21062917.
      View in: PubMed
    87. Dobaczewski M, Chen W, Frangogiannis NG. Transforming growth factor (TGF)-ß signaling in cardiac remodeling. J Mol Cell Cardiol. 2011 Oct; 51(4):600-6. PMID: 21059352.
      View in: PubMed
    88. Chen W, Frangogiannis NG. The role of inflammatory and fibrogenic pathways in heart failure associated with aging. Heart Fail Rev. 2010 Sep; 15(5):415-22. PMID: 20213186.
      View in: PubMed
    89. Dobaczewski M, Bujak M, Li N, Gonzalez-Quesada C, Mendoza LH, Wang XF, Frangogiannis NG. Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. Circ Res. 2010 Aug 06; 107(3):418-28. PMID: 20522804.
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    90. Dobaczewski M, Xia Y, Bujak M, Gonzalez-Quesada C, Frangogiannis NG. CCR5 signaling suppresses inflammation and reduces adverse remodeling of the infarcted heart, mediating recruitment of regulatory T cells. Am J Pathol. 2010 May; 176(5):2177-87. PMID: 20382703.
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    91. Frangogiannis NG. Syndecan-1: a critical mediator in cardiac fibrosis. Hypertension. 2010 Feb; 55(2):233-5. PMID: 20048190.
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    92. Durgan DJ, Pulinilkunnil T, Villegas-Montoya C, Garvey ME, Frangogiannis NG, Michael LH, Chow CW, Dyck JR, Young ME. Short communication: ischemia/reperfusion tolerance is time-of-day-dependent: mediation by the cardiomyocyte circadian clock. Circ Res. 2010 Feb 19; 106(3):546-50. PMID: 20007913.
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    93. Bujak M, Dobaczewski M, Gonzalez-Quesada C, Xia Y, Leucker T, Zymek P, Veeranna V, Tager AM, Luster AD, Frangogiannis NG. Induction of the CXC chemokine interferon-gamma-inducible protein 10 regulates the reparative response following myocardial infarction. Circ Res. 2009 Nov 06; 105(10):973-83. PMID: 19797174.
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    94. Dobaczewski M, Gonzalez-Quesada C, Frangogiannis NG. The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction. J Mol Cell Cardiol. 2010 Mar; 48(3):504-11. PMID: 19631653.
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    95. Dobaczewski M, Frangogiannis NG. Chemokines and cardiac fibrosis. Front Biosci (Schol Ed). 2009 Jun 01; 1:391-405. PMID: 19482709.
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    96. Bujak M, Frangogiannis NG. The role of IL-1 in the pathogenesis of heart disease. Arch Immunol Ther Exp (Warsz). 2009 May-Jun; 57(3):165-76. PMID: 19479203.
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    97. Gonzalez-Quesada C, Frangogiannis NG. Monocyte chemoattractant protein-1/CCL2 as a biomarker in acute coronary syndromes. Curr Atheroscler Rep. 2009 Mar; 11(2):131-8. PMID: 19228487.
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    98. Xia Y, Lee K, Li N, Corbett D, Mendoza L, Frangogiannis NG. Characterization of the inflammatory and fibrotic response in a mouse model of cardiac pressure overload. Histochem Cell Biol. 2009 Apr; 131(4):471-81. PMID: 19030868.
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    99. Thakker GD, Frangogiannis NG, Zymek PT, Sharma S, Raya JL, Barger PM, Taegtmeyer H, Entman ML, Ballantyne CM. Increased myocardial susceptibility to repetitive ischemia with high-fat diet-induced obesity. Obesity (Silver Spring). 2008 Dec; 16(12):2593-600. PMID: 18833212.
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    100. Dobaczewski M, Frangogiannis NG. Chemokines in myocardial infarction: translating basic research into clinical medicine. Future Cardiol. 2008 Jul; 4(4):347-51. PMID: 19804314.
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    101. Frangogiannis NG. The immune system and cardiac repair. Pharmacol Res. 2008 Aug; 58(2):88-111. PMID: 18620057.
      View in: PubMed
    102. Bujak M, Dobaczewski M, Chatila K, Mendoza LH, Li N, Reddy A, Frangogiannis NG. Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling. Am J Pathol. 2008 Jul; 173(1):57-67. PMID: 18535174.
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    103. Bujak M, Kweon HJ, Chatila K, Li N, Taffet G, Frangogiannis NG. Aging-related defects are associated with adverse cardiac remodeling in a mouse model of reperfused myocardial infarction. J Am Coll Cardiol. 2008 Apr 08; 51(14):1384-92. PMID: 18387441.
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    104. Huebener P, Abou-Khamis T, Zymek P, Bujak M, Ying X, Chatila K, Haudek S, Thakker G, Frangogiannis NG. CD44 is critically involved in infarct healing by regulating the inflammatory and fibrotic response. J Immunol. 2008 Feb 15; 180(4):2625-33. PMID: 18250474.
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    105. Rao L, Ling Y, He R, Gilbert AL, Frangogiannis NG, Wang J, Nagueh SF, Khoury DS. Integrated multimodal-catheter imaging unveils principal relationships among ventricular electrical activity, anatomy, and function. Am J Physiol Heart Circ Physiol. 2008 Feb; 294(2):H1002-9. PMID: 18083892.
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    106. Frangogiannis NG. The prognostic value of monocyte chemoattractant protein-1/CCL2 in acute coronary syndromes. J Am Coll Cardiol. 2007 Nov 27; 50(22):2125-7. PMID: 18036448.
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    107. Bujak M, Ren G, Kweon HJ, Dobaczewski M, Reddy A, Taffet G, Wang XF, Frangogiannis NG. Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling. Circulation. 2007 Nov 06; 116(19):2127-38. PMID: 17967775.
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    108. Xia Y, Frangogiannis NG. MCP-1/CCL2 as a therapeutic target in myocardial infarction and ischemic cardiomyopathy. Inflamm Allergy Drug Targets. 2007 Jun; 6(2):101-7. PMID: 17692033.
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    109. Frangogiannis NG. Chemokines in ischemia and reperfusion. Thromb Haemost. 2007 May; 97(5):738-47. PMID: 17479184.
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    110. Frangogiannis NG, Dewald O, Xia Y, Ren G, Haudek S, Leucker T, Kraemer D, Taffet G, Rollins BJ, Entman ML. Critical role of monocyte chemoattractant protein-1/CC chemokine ligand 2 in the pathogenesis of ischemic cardiomyopathy. Circulation. 2007 Feb 06; 115(5):584-92. PMID: 17283277.
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    111. Chatila K, Ren G, Xia Y, Huebener P, Bujak M, Frangogiannis NG. The role of the thrombospondins in healing myocardial infarcts. Cardiovasc Hematol Agents Med Chem. 2007 Jan; 5(1):21-7. PMID: 17266545.
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    112. Zymek P, Nah DY, Bujak M, Ren G, Koerting A, Leucker T, Huebener P, Taffet G, Entman M, Frangogiannis NG. Interleukin-10 is not a critical regulator of infarct healing and left ventricular remodeling. Cardiovasc Res. 2007 May 01; 74(2):313-22. PMID: 17188669.
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    113. Haudek SB, Xia Y, Huebener P, Lee JM, Carlson S, Crawford JR, Pilling D, Gomer RH, Trial J, Frangogiannis NG, Entman ML. Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice. Proc Natl Acad Sci U S A. 2006 Nov 28; 103(48):18284-9. PMID: 17114286.
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    114. Zymek P, Bujak M, Chatila K, Cieslak A, Thakker G, Entman ML, Frangogiannis NG. The role of platelet-derived growth factor signaling in healing myocardial infarcts. J Am Coll Cardiol. 2006 Dec 05; 48(11):2315-23. PMID: 17161265.
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    115. Frangogiannis NG. The mechanistic basis of infarct healing. Antioxid Redox Signal. 2006 Nov-Dec; 8(11-12):1907-39. PMID: 17034340.
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    116. Bujak M, Frangogiannis NG. The role of TGF-beta signaling in myocardial infarction and cardiac remodeling. Cardiovasc Res. 2007 May 01; 74(2):184-95. PMID: 17109837.
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    117. Thakker GD, Frangogiannis NG, Bujak M, Zymek P, Gaubatz JW, Reddy AK, Taffet G, Michael LH, Entman ML, Ballantyne CM. Effects of diet-induced obesity on inflammation and remodeling after myocardial infarction. Am J Physiol Heart Circ Physiol. 2006 Nov; 291(5):H2504-14. PMID: 16731644.
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    118. Dobaczewski M, Bujak M, Zymek P, Ren G, Entman ML, Frangogiannis NG. Extracellular matrix remodeling in canine and mouse myocardial infarcts. Cell Tissue Res. 2006 Jun; 324(3):475-88. PMID: 16496177.
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    119. Frangogiannis NG, Entman ML. Identification of mast cells in the cellular response to myocardial infarction. Methods Mol Biol. 2006; 315:91-101. PMID: 16110151.
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    120. Frangogiannis NG. Targeting the inflammatory response in healing myocardial infarcts. Curr Med Chem. 2006; 13(16):1877-93. PMID: 16842199.
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    121. Park TH, Nagueh SF, Khoury DS, Kopelen HA, Akrivakis S, Nasser K, Ren G, Frangogiannis NG. Impact of myocardial structure and function postinfarction on diastolic strain measurements: implications for assessment of myocardial viability. Am J Physiol Heart Circ Physiol. 2006 Feb; 290(2):H724-31. PMID: 16183729.
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    122. Frangogiannis NG, Entman ML. Chemokines in myocardial ischemia. Trends Cardiovasc Med. 2005 Jul; 15(5):163-9. PMID: 16165012.
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    123. Frangogiannis NG, Ren G, Dewald O, Zymek P, Haudek S, Koerting A, Winkelmann K, Michael LH, Lawler J, Entman ML. Critical role of endogenous thrombospondin-1 in preventing expansion of healing myocardial infarcts. Circulation. 2005 Jun 07; 111(22):2935-42. PMID: 15927970.
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    124. Dewald O, Zymek P, Winkelmann K, Koerting A, Ren G, Abou-Khamis T, Michael LH, Rollins BJ, Entman ML, Frangogiannis NG. CCL2/Monocyte Chemoattractant Protein-1 regulates inflammatory responses critical to healing myocardial infarcts. Circ Res. 2005 Apr 29; 96(8):881-9. PMID: 15774854.
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    125. Somasundaram P, Ren G, Nagar H, Kraemer D, Mendoza L, Michael LH, Caughey GH, Entman ML, Frangogiannis NG. Mast cell tryptase may modulate endothelial cell phenotype in healing myocardial infarcts. J Pathol. 2005 Jan; 205(1):102-11. PMID: 15586361.
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    126. Frangogiannis NG. Chemokines in the ischemic myocardium: from inflammation to fibrosis. Inflamm Res. 2004 Nov; 53(11):585-95. PMID: 15693606.
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    127. Dewald O, Frangogiannis NG, Zoerlein MP, Duerr GD, Taffet G, Michael LH, Welz A, Entman ML. A murine model of ischemic cardiomyopathy induced by repetitive ischemia and reperfusion. Thorac Cardiovasc Surg. 2004 Oct; 52(5):305-11. PMID: 15470614.
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    128. Frangogiannis NG, Entman ML. Targeting the chemokines in myocardial inflammation. Circulation. 2004 Sep 14; 110(11):1341-2. PMID: 15364818.
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    129. Dobaczewski M, Akrivakis S, Nasser K, Michael LH, Entman ML, Frangogiannis NG. Vascular mural cells in healing canine myocardial infarcts. J Histochem Cytochem. 2004 Aug; 52(8):1019-29. PMID: 15258177.
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    130. Frangogiannis NG. The role of the chemokines in myocardial ischemia and reperfusion. Curr Vasc Pharmacol. 2004 Apr; 2(2):163-74. PMID: 15320517.
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    131. Dewald O, Ren G, Duerr GD, Zoerlein M, Klemm C, Gersch C, Tincey S, Michael LH, Entman ML, Frangogiannis NG. Of mice and dogs: species-specific differences in the inflammatory response following myocardial infarction. Am J Pathol. 2004 Feb; 164(2):665-77. PMID: 14742270.
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    132. Ren G, Dewald O, Frangogiannis NG. Inflammatory mechanisms in myocardial infarction. Curr Drug Targets Inflamm Allergy. 2003 Sep; 2(3):242-56. PMID: 14561159.
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    133. Frangogiannis NG. Myocardial hibernation. Clinical and pathological perspectives. Minerva Cardioangiol. 2003 Jun; 51(3):261-74. PMID: 12867878.
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    134. Frangogiannis NG, Mendoza LH, Ren G, Akrivakis S, Jackson PL, Michael LH, Smith CW, Entman ML. MCSF expression is induced in healing myocardial infarcts and may regulate monocyte and endothelial cell phenotype. Am J Physiol Heart Circ Physiol. 2003 Aug; 285(2):H483-92. PMID: 12689859.
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    135. Frangogiannis NG. The pathological basis of myocardial hibernation. Histol Histopathol. 2003 04; 18(2):647-55. PMID: 12647814.
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    136. Dewald O, Frangogiannis NG, Zoerlein M, Duerr GD, Klemm C, Knuefermann P, Taffet G, Michael LH, Crapo JD, Welz A, Entman ML. Development of murine ischemic cardiomyopathy is associated with a transient inflammatory reaction and depends on reactive oxygen species. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2700-5. PMID: 12586861.
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    137. Shimoni S, Frangogiannis NG, Aggeli CJ, Shan K, Verani MS, Quinones MA, Espada R, Letsou GV, Lawrie GM, Winters WL, Reardon MJ, Zoghbi WA. Identification of hibernating myocardium with quantitative intravenous myocardial contrast echocardiography: comparison with dobutamine echocardiography and thallium-201 scintigraphy. Circulation. 2003 Feb 04; 107(4):538-44. PMID: 12566363.
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    138. Fernandes LS, Conde ID, Wayne Smith C, Kansas GS, Snapp KR, Bennet N, Ballantyne C, McIntire LV, O'Brian Smith E, Klem JA, Mathew S, Frangogiannis N, Turner NA, Maresh KJ, Kleiman NS. Platelet-monocyte complex formation: effect of blocking PSGL-1 alone, and in combination with alphaIIbbeta3 and alphaMbeta2, in coronary stenting. Thromb Res. 2003; 111(3):171-7. PMID: 14678816.
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    139. Shimoni S, Frangogiannis NG, Aggeli CJ, Shan K, Quinones MA, Espada R, Letsou GV, Lawrie GM, Winters WL, Reardon MJ, Zoghbi WA. Microvascular structural correlates of myocardial contrast echocardiography in patients with coronary artery disease and left ventricular dysfunction: implications for the assessment of myocardial hibernation. Circulation. 2002 Aug 20; 106(8):950-6. PMID: 12186799.
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    140. Gersch C, Dewald O, Zoerlein M, Michael LH, Entman ML, Frangogiannis NG. Mast cells and macrophages in normal C57/BL/6 mice. Histochem Cell Biol. 2002 Jul; 118(1):41-9. PMID: 12122446.
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    141. Frangogiannis NG, Shimoni S, Chang SM, Ren G, Dewald O, Gersch C, Shan K, Aggeli C, Reardon M, Letsou GV, Espada R, Ramchandani M, Entman ML, Zoghbi WA. Active interstitial remodeling: an important process in the hibernating human myocardium. J Am Coll Cardiol. 2002 May 01; 39(9):1468-74. PMID: 11985909.
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    142. Frangogiannis NG, Shimoni S, Chang SM, Ren G, Shan K, Aggeli C, Reardon MJ, Letsou GV, Espada R, Ramchandani M, Entman ML, Zoghbi WA. Evidence for an active inflammatory process in the hibernating human myocardium. Am J Pathol. 2002 Apr; 160(4):1425-33. PMID: 11943726.
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    143. Ren G, Michael LH, Entman ML, Frangogiannis NG. Morphological characteristics of the microvasculature in healing myocardial infarcts. J Histochem Cytochem. 2002 Jan; 50(1):71-9. PMID: 11748296.
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    144. Frangogiannis NG, Smith CW, Entman ML. The inflammatory response in myocardial infarction. Cardiovasc Res. 2002 Jan; 53(1):31-47. PMID: 11744011.
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    145. Nossuli TO, Frangogiannis NG, Knuefermann P, Lakshminarayanan V, Dewald O, Evans AJ, Peschon J, Mann DL, Michael LH, Entman ML. Brief murine myocardial I/R induces chemokines in a TNF-alpha-independent manner: role of oxygen radicals. Am J Physiol Heart Circ Physiol. 2001 Dec; 281(6):H2549-58. PMID: 11709422.
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    146. Lakshminarayanan V, Lewallen M, Frangogiannis NG, Evans AJ, Wedin KE, Michael LH, Entman ML. Reactive oxygen intermediates induce monocyte chemotactic protein-1 in vascular endothelium after brief ischemia. Am J Pathol. 2001 Oct; 159(4):1301-11. PMID: 11583958.
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    147. Frangogiannis NG, Mendoza LH, Lewallen M, Michael LH, Smith CW, Entman ML. Induction and suppression of interferon-inducible protein 10 in reperfused myocardial infarcts may regulate angiogenesis. FASEB J. 2001 Jun; 15(8):1428-30. PMID: 11387246.
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    148. Frangogiannis NG, Mendoza LH, Smith CW, Michael LH, Entman ML. Induction of the synthesis of the C-X-C chemokine interferon-gamma-inducible protein-10 in experimental canine endotoxemia. Cell Tissue Res. 2000 Dec; 302(3):365-76. PMID: 11151448.
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    149. Frangogiannis NG, Michael LH, Entman ML. Myofibroblasts in reperfused myocardial infarcts express the embryonic form of smooth muscle myosin heavy chain (SMemb). Cardiovasc Res. 2000 Oct; 48(1):89-100. PMID: 11033111.
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    150. Frangogiannis NG, Mendoza LH, Lindsey ML, Ballantyne CM, Michael LH, Smith CW, Entman ML. IL-10 is induced in the reperfused myocardium and may modulate the reaction to injury. J Immunol. 2000 Sep 01; 165(5):2798-808. PMID: 10946312.
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    151. Entman ML, Youker KA, Frangogiannis N, Lakshminarayanan V, Nossuli T, Evans A, Kurrelmeyer K, Mann DL, Smith CW. Is inflammation good for the ischemic heart--perspectives beyond the ordinary. Z Kardiol. 2000; 89 Suppl 9:IX/82-7. PMID: 11151802.
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    152. Frangogiannis NG, Farmer JA, Lakkis NM. Tirofiban for cocaine-induced coronary artery thrombosis: a novel therapeutic approach. Circulation. 1999 Nov 02; 100(18):1939. PMID: 10545440.
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    153. Frangogiannis NG, Burns AR, Michael LH, Entman ML. Histochemical and morphological characteristics of canine cardiac mast cells. Histochem J. 1999 Apr; 31(4):221-9. PMID: 10447063.
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    154. Gwechenberger M, Mendoza LH, Youker KA, Frangogiannis NG, Smith CW, Michael LH, Entman ML. Cardiac myocytes produce interleukin-6 in culture and in viable border zone of reperfused infarctions. Circulation. 1999 Feb 02; 99(4):546-51. PMID: 9927402.
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    155. Frangogiannis NG, Youker KA, Rossen RD, Gwechenberger M, Lindsey MH, Mendoza LH, Michael LH, Ballantyne CM, Smith CW, Entman ML. Cytokines and the microcirculation in ischemia and reperfusion. J Mol Cell Cardiol. 1998 Dec; 30(12):2567-76. PMID: 9990529.
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    156. Frangogiannis NG, Cate TR. Endocarditis and Ureaplasma urealyticum osteomyelitis in a hypogammaglobulinemic patient. A case report and review of the literature. J Infect. 1998 Sep; 37(2):181-4. PMID: 9821094.
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    157. Frangogiannis NG, Lindsey ML, Michael LH, Youker KA, Bressler RB, Mendoza LH, Spengler RN, Smith CW, Entman ML. Resident cardiac mast cells degranulate and release preformed TNF-alpha, initiating the cytokine cascade in experimental canine myocardial ischemia/reperfusion. Circulation. 1998 Aug 18; 98(7):699-710. PMID: 9715863.
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    158. Frangogiannis NG, Perrard JL, Mendoza LH, Burns AR, Lindsey ML, Ballantyne CM, Michael LH, Smith CW, Entman ML. Stem cell factor induction is associated with mast cell accumulation after canine myocardial ischemia and reperfusion. Circulation. 1998 Aug 18; 98(7):687-98. PMID: 9715862.
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    159. Youker KA, Birdsall HH, Frangogiannis NG, Kumar AG, Lindsey ML, Ballantyne CM, Smith CW, Rossen RD, Entman ML. Phagocytes in ischemia injury. Ann N Y Acad Sci. 1997 Dec 15; 832:243-65. PMID: 9704052.
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    160. Frangogiannis NG, Boridy I, Mazhar M, Mathews R, Gangopadhyay S, Cate T. Cyclophosphamide in the treatment of toxic epidermal necrolysis. South Med J. 1996 Oct; 89(10):1001-3. PMID: 8865797.
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    161. Frangogiannis NG, Youker KA, Entman ML. The role of the neutrophil in myocardial ischemia and reperfusion. EXS. 1996; 76:263-84. PMID: 8805800.
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    162. Frangogiannis NG, Gangopadhyay S, Cate T. Pemphigus of the larynx and esophagus. Ann Intern Med. 1995 May 15; 122(10):803-4. PMID: 7717612.
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