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NICHOLAS JAY WEBSTER

TitleGraduate Student
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Human Genetics
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    R01DK044643     (WEBSTER, NICHOLAS J)Sep 30, 1992 - Sep 30, 1996
    NIH/NIDDK
    INACTIVATION AND IN VIVO MUTAGENESIS OF THE IR GENE
    Role: Principal Investigator

    R03AG023191     (WEBSTER, NICHOLAS J)Dec 15, 2003 - Nov 30, 2005
    NIH/NIA
    Combinatorial Approaches to Activators of the NGF Recep*
    Role: Principal Investigator

    R01HD047400     (WEBSTER, NICHOLAS J)Jul 1, 2005 - Apr 30, 2011
    NIH/NICHD
    GnRH signaling in LbetaT2 gonadotrope cells
    Role: Principal Investigator

    I01BX000130     (WEBSTER, NICHOLAS J)Apr 1, 2010 - Mar 31, 2014
    VA
    Alternative Splicing of the Insulin Receptor Gene
    Role: Principal Investigator

    I01BX002709     (WEBSTER, NICHOLAS J)Jan 1, 2016 - Dec 31, 2019
    VA
    SRSF3 Loss and Hepatocellular Carcinoma
    Role: Principal Investigator

    R01CA196853     (WEBSTER, NICHOLAS J)Apr 1, 2016 - Mar 31, 2021
    NIH/NCI
    Time-Restricted Feeding and Breast Cancer
    Role: Principal Investigator

    IS1BX004386     (WEBSTER, NICHOLAS J)Jan 1, 2018 - Sep 30, 2018
    VA
    ShEEP Request for Beckman-Coulter Optima XPN 100 Ultracentrifuge
    Role: Principal Investigator

    R01HL141999     (RAZ, EYAL)Jan 1, 2019 - Dec 31, 2022
    NIH/NHLBI
    A novel pathway of Th17/Th2 induction: The role of cAMP signaling in DC
    Role: Co-Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rickert E, Fernandez MO, Choi I, Gorman M, Olefsky JM, Webster NJG. Neuronal SIRT1 Regulates Metabolic and Reproductive Function and the Response to Caloric Restriction. J Endocr Soc. 2019 Feb 01; 3(2):427-445. PMID: 30746504.
      View in: PubMed
    2. Sahu BS, Mahata S, Bandyopadhyay K, Mahata M, Avolio E, Pasqua T, Sahu C, Bandyopadhyay GK, Bartolomucci A, Webster NJG, Van Den Bogaart G, Fischer-Colbrie R, Corti A, Eiden LE, Mahata SK. Catestatin regulates vesicular quanta through modulation of cholinergic and peptidergic (PACAPergic) stimulation in PC12 cells. Cell Tissue Res. 2018 Nov 22. PMID: 30467710.
      View in: PubMed
    3. Dawson EP, Lanza DG, Webster NJ, Benton SM, Suetake I, Heaney JD. Delayed male germ cell sex-specification permits transition into embryonal carcinoma cells with features of primed pluripotency. Development. 2018 03 15; 145(6). PMID: 29545285.
      View in: PubMed
    4. Ying W, Mahata S, Bandyopadhyay GK, Zhou Z, Wollam J, Vu J, Mayoral R, Chi NW, Webster NJG, Corti A, Mahata SK. Catestatin Inhibits Obesity-Induced Macrophage Infiltration and Inflammation in the Liver and Suppresses Hepatic Glucose Production, Leading to Improved Insulin Sensitivity. Diabetes. 2018 05; 67(5):841-848. PMID: 29432123.
      View in: PubMed
    5. Fernandez MO, Hsueh K, Park HT, Sauceda C, Hwang V, Kumar D, Kim S, Rickert E, Mahata S, Webster NJG. Astrocyte-Specific Deletion of Peroxisome-Proliferator Activated Receptor-? Impairs Glucose Metabolism and Estrous Cycling in Female Mice. J Endocr Soc. 2017 Nov 01; 1(11):1332-1350. PMID: 29264458.
      View in: PubMed
    6. Webster NJG. Alternative RNA Splicing in the Pathogenesis of Liver Disease. Front Endocrinol (Lausanne). 2017; 8:133. PMID: 28680417.
      View in: PubMed
    7. Wollam J, Mahata S, Riopel M, Hernandez-Carretero A, Biswas A, Bandyopadhyay GK, Chi NW, Eiden LE, Mahapatra NR, Corti A, Webster NJG, Mahata SK. Chromogranin A regulates vesicle storage and mitochondrial dynamics to influence insulin secretion. Cell Tissue Res. 2017 06; 368(3):487-501. PMID: 28220294.
      View in: PubMed
    8. Fernandez MO, Sharma S, Kim S, Rickert E, Hsueh K, Hwang V, Olefsky JM, Webster NJ. Obese Neuronal PPAR? Knockout Mice Are Leptin Sensitive but Show Impaired Glucose Tolerance and Fertility. Endocrinology. 2017 01 01; 158(1):121-133. PMID: 27841948.
      View in: PubMed
    9. Tang K, Pasqua T, Biswas A, Mahata S, Tang J, Tang A, Bandyopadhyay GK, Sinha-Hikim AP, Chi NW, Webster NJ, Corti A, Mahata SK. Muscle injury, impaired muscle function and insulin resistance in Chromogranin A-knockout mice. J Endocrinol. 2017 02; 232(2):137-153. PMID: 27799464.
      View in: PubMed
    10. Cho CG, Pak K, Webster N, Kurabi A, Ryan AF. Both canonical and non-canonical NF-?B activation contribute to the proliferative response of the middle ear mucosa during bacterial infection. Innate Immun. 2016 11; 22(8):626-634. PMID: 27655045.
      View in: PubMed
    11. Chung H, Chou W, Sears DD, Patterson RE, Webster NJ, Ellies LG. Time-restricted feeding improves insulin resistance and hepatic steatosis in a mouse model of postmenopausal obesity. Metabolism. 2016 Dec; 65(12):1743-1754. PMID: 27832862.
      View in: PubMed
    12. Huang PP, Brusman LE, Iyer AK, Webster NJ, Mellon PL. A Novel Gonadotropin-Releasing Hormone 1 (Gnrh1) Enhancer-Derived Noncoding RNA Regulates Gnrh1 Gene Expression in GnRH Neuronal Cell Models. PLoS One. 2016; 11(7):e0158597. PMID: 27389022; PMCID: PMC4936741.
    13. Kauffman AS, Thackray VG, Ryan GE, Tolson KP, Glidewell-Kenney CA, Semaan SJ, Poling MC, Iwata N, Breen KM, Duleba AJ, Stener-Victorin E, Shimasaki S, Webster NJ, Mellon PL. A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice. Biol Reprod. 2015 Sep; 93(3):69. PMID: 26203175; PMCID: PMC4710190.
    14. Hernandez M, Leichtle A, Pak K, Webster NJ, Wasserman SI, Ryan AF. The transcriptome of a complete episode of acute otitis media. BMC Genomics. 2015 Apr 03; 16:259. PMID: 25888408; PMCID: PMC4394589.
    15. Lee J, Kim TH, Murray F, Li X, Choi SS, Broide DH, Corr M, Lee J, Webster NJ, Insel PA, Raz E. Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1529-34. PMID: 25605931; PMCID: PMC4321256.
    16. Sen S, Langiewicz M, Jumaa H, Webster NJ. Deletion of serine/arginine-rich splicing factor 3 in hepatocytes predisposes to hepatocellular carcinoma in mice. Hepatology. 2015 Jan; 61(1):171-83. PMID: 25132062; PMCID: PMC4280350.
    17. Yao W, Frie M, Pan J, Pak K, Webster N, Wasserman SI, Ryan AF. C-Jun N-terminal kinase (JNK) isoforms play differing roles in otitis media. BMC Immunol. 2014 Oct 14; 15:46. PMID: 25311344; PMCID: PMC4200133.
    18. Chung H, Lee YS, Mayoral R, Oh DY, Siu JT, Webster NJ, Sears DD, Olefsky JM, Ellies LG. Omega-3 fatty acids reduce obesity-induced tumor progression independent of GPR120 in a mouse model of postmenopausal breast cancer. Oncogene. 2015 Jul; 34(27):3504-13. PMID: 25220417; PMCID: PMC4362785.
    19. Schwaederle M, Parker BA, Schwab RB, Fanta PT, Boles SG, Daniels GA, Bazhenova LA, Subramanian R, Coutinho AC, Ojeda-Fournier H, Datnow B, Webster NJ, Lippman SM, Kurzrock R. Molecular tumor board: the University of California-San Diego Moores Cancer Center experience. Oncologist. 2014 Jun; 19(6):631-6. PMID: 24797821; PMCID: PMC4041669.
    20. Sharma S, Morinaga H, Hwang V, Fan W, Fernandez MO, Varki N, Olefsky JM, Webster NJ. Free fatty acids induce Lhb mRNA but suppress Fshb mRNA in pituitary LßT2 gonadotropes and diet-induced obesity reduces FSH levels in male mice and disrupts the proestrous LH/FSH surge in female mice. Endocrinology. 2013 Jun; 154(6):2188-99. PMID: 23525221; PMCID: PMC3740488.
    21. Sen S, Jumaa H, Webster NJ. Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function. Nat Commun. 2013; 4:1336. PMID: 23299886; PMCID: PMC4314219.
    22. Ricaldi JN, Fouts DE, Selengut JD, Harkins DM, Patra KP, Moreno A, Lehmann JS, Purushe J, Sanka R, Torres M, Webster NJ, Vinetz JM, Matthias MA. Whole genome analysis of Leptospira licerasiae provides insight into leptospiral evolution and pathogenicity. PLoS Negl Trop Dis. 2012; 6(10):e1853. PMID: 23145189; PMCID: PMC3493377.
    23. Talukdar I, Sen S, Urbano R, Thompson J, Yates JR, Webster NJ. hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene. PLoS One. 2011; 6(11):e27869. PMID: 22132154; PMCID: PMC3223206.
    24. Nazari H, Khaleghian A, Takahashi A, Harada N, Webster NJ, Nakano M, Kishi K, Ebina Y, Nakaya Y. Cortactin, an actin binding protein, regulates GLUT4 translocation via actin filament remodeling. Biochemistry (Mosc). 2011 Nov; 76(11):1262-9. PMID: 22117553; PMCID: PMC4313749.
    25. Mistry DS, Tsutsumi R, Fernandez M, Sharma S, Cardenas SA, Lawson MA, Webster NJ. Gonadotropin-releasing hormone pulse sensitivity of follicle-stimulating hormone-beta gene is mediated by differential expression of positive regulatory activator protein 1 factors and corepressors SKIL and TGIF1. Mol Endocrinol. 2011 Aug; 25(8):1387-403. PMID: 21659477; PMCID: PMC3146254.
    26. Lan D, Lu M, Sharma S, Mellon PL, Olefsky JM, Webster NJ. Trans-resveratrol inhibits phosphorylation of Smad2/3 and represses FSHß gene expression by a SirT1-independent pathway in LßT2 gonadotrope cells. Reprod Toxicol. 2011 Jul; 32(1):85-92. PMID: 21679764; PMCID: PMC3155991.
    27. Lu M, Sarruf DA, Talukdar S, Sharma S, Li P, Bandyopadhyay G, Nalbandian S, Fan W, Gayen JR, Mahata SK, Webster NJ, Schwartz MW, Olefsky JM. Brain PPAR-? promotes obesity and is required for the insulin-sensitizing effect of thiazolidinediones. Nat Med. 2011 May; 17(5):618-22. PMID: 21532596; PMCID: PMC3380629.
    28. Godoy J, Nishimura M, Webster NJ. Gonadotropin-releasing hormone induces miR-132 and miR-212 to regulate cellular morphology and migration in immortalized LbetaT2 pituitary gonadotrope cells. Mol Endocrinol. 2011 May; 25(5):810-20. PMID: 21372146; PMCID: PMC3082323.
    29. Leichtle A, Hernandez M, Lee J, Pak K, Webster NJ, Wollenberg B, Wasserman SI, Ryan AF. The role of DNA sensing and innate immune receptor TLR9 in otitis media. Innate Immun. 2012 Feb; 18(1):3-13. PMID: 21239460; PMCID: PMC4041324.
    30. Sharma S, Sharma PM, Mistry DS, Chang RJ, Olefsky JM, Mellon PL, Webster NJ. PPARG regulates gonadotropin-releasing hormone signaling in LbetaT2 cells in vitro and pituitary gonadotroph function in vivo in mice. Biol Reprod. 2011 Mar; 84(3):466-75. PMID: 21076077; PMCID: PMC3043129.
    31. Nguyen KA, Intriago RE, Upadhyay HC, Santos SJ, Webster NJ, Lawson MA. Modulation of gonadotropin-releasing hormone-induced extracellular signal-regulated kinase activation by dual-specificity protein phosphatase 1 in LbetaT2 gonadotropes. Endocrinology. 2010 Oct; 151(10):4882-93. PMID: 20685880; PMCID: PMC2946148.
    32. Sen S, Talukdar I, Liu Y, Tam J, Reddy S, Webster NJ. Muscleblind-like 1 (Mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer. J Biol Chem. 2010 Aug 13; 285(33):25426-37. PMID: 20519504; PMCID: PMC2919106.
    33. Datta SK, Sabet M, Nguyen KP, Valdez PA, Gonzalez-Navajas JM, Islam S, Mihajlov I, Fierer J, Insel PA, Webster NJ, Guiney DG, Raz E. Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10638-43. PMID: 20479237; PMCID: PMC2890829.
    34. Tsutsumi R, Mistry D, Webster NJ. Signaling responses to pulsatile gonadotropin-releasing hormone in LbetaT2 gonadotrope cells. J Biol Chem. 2010 Jun 25; 285(26):20262-72. PMID: 20406815; PMCID: PMC2888439.
    35. Leichtle A, Hernandez M, Pak K, Webster NJ, Wasserman SI, Ryan AF. The toll-Like receptor adaptor TRIF contributes to otitis media pathogenesis and recovery. BMC Immunol. 2009 Aug 05; 10:45. PMID: 19656404; PMCID: PMC2736931.
    36. Tsutsumi R, Webster NJ. GnRH pulsatility, the pituitary response and reproductive dysfunction. Endocr J. 2009; 56(6):729-37. PMID: 19609045; PMCID: PMC4307809.
    37. Leichtle A, Hernandez M, Pak K, Yamasaki K, Cheng CF, Webster NJ, Ryan AF, Wasserman SI. TLR4-mediated induction of TLR2 signaling is critical in the pathogenesis and resolution of otitis media. Innate Immun. 2009 Aug; 15(4):205-15. PMID: 19586996; PMCID: PMC3565845.
    38. Beevers CS, Chen L, Liu L, Luo Y, Webster NJ, Huang S. Curcumin disrupts the Mammalian target of rapamycin-raptor complex. Cancer Res. 2009 Feb 01; 69(3):1000-8. PMID: 19176385; PMCID: PMC4307947.
    39. Hernandez M, Leichtle A, Pak K, Ebmeyer J, Euteneuer S, Obonyo M, Guiney DG, Webster NJ, Broide DH, Ryan AF, Wasserman SI. Myeloid differentiation primary response gene 88 is required for the resolution of otitis media. J Infect Dis. 2008 Dec 15; 198(12):1862-9. PMID: 18986247; PMCID: PMC3584630.
    40. Webster NJ, Pirrung MC. Small molecule activators of the Trk receptors for neuroprotection. BMC Neurosci. 2008 Dec 03; 9 Suppl 2:S1. PMID: 19090982; PMCID: PMC2604901.
    41. Sen S, Talukdar I, Webster NJ. SRp20 and CUG-BP1 modulate insulin receptor exon 11 alternative splicing. Mol Cell Biol. 2009 Feb; 29(3):871-80. PMID: 19047369; PMCID: PMC2630670.
    42. Chandrasekar B, Boylston WH, Venkatachalam K, Webster NJ, Prabhu SD, Valente AJ. Adiponectin blocks interleukin-18-mediated endothelial cell death via APPL1-dependent AMP-activated protein kinase (AMPK) activation and IKK/NF-kappaB/PTEN suppression. J Biol Chem. 2008 Sep 05; 283(36):24889-98. PMID: 18632660; PMCID: PMC3259831.
    43. Pirrung MC, Deng L, Lin B, Webster NJ. Quinone replacements for small molecule insulin mimics. Chembiochem. 2008 Feb 15; 9(3):360-2. PMID: 18232038.
      View in: PubMed
    44. Lu M, Tang Q, Olefsky JM, Mellon PL, Webster NJ. Adiponectin activates adenosine monophosphate-activated protein kinase and decreases luteinizing hormone secretion in LbetaT2 gonadotropes. Mol Endocrinol. 2008 Mar; 22(3):760-71. PMID: 18006641; PMCID: PMC2262174.
    45. Lin B, Li Z, Park K, Deng L, Pai A, Zhong L, Pirrung MC, Webster NJ. Identification of novel orally available small molecule insulin mimetics. J Pharmacol Exp Ther. 2007 Nov; 323(2):579-85. PMID: 17687071.
      View in: PubMed
    46. Pirrung MC, Li Z, Hensley E, Liu Y, Tanksale A, Lin B, Pai A, Webster NJ. Parallel synthesis of indolylquinones and their cell-based insulin mimicry. J Comb Chem. 2007 Sep-Oct; 9(5):844-54. PMID: 17595147.
      View in: PubMed
    47. Lin B, Pirrung MC, Deng L, Li Z, Liu Y, Webster NJ. Neuroprotection by small molecule activators of the nerve growth factor receptor. J Pharmacol Exp Ther. 2007 Jul; 322(1):59-69. PMID: 17468299.
      View in: PubMed
    48. Furukawa M, Ebmeyer J, Pak K, Austin DA, Melhus A, Webster NJ, Ryan AF. Jun N-terminal protein kinase enhances middle ear mucosal proliferation during bacterial otitis media. Infect Immun. 2007 May; 75(5):2562-71. PMID: 17325051; PMCID: PMC1865762.
    49. Lawson MA, Tsutsumi R, Zhang H, Talukdar I, Butler BK, Santos SJ, Mellon PL, Webster NJ. Pulse sensitivity of the luteinizing hormone beta promoter is determined by a negative feedback loop Involving early growth response-1 and Ngfi-A binding protein 1 and 2. Mol Endocrinol. 2007 May; 21(5):1175-91. PMID: 17299135; PMCID: PMC2932486.
    50. Chung WH, Pak K, Lin B, Webster N, Ryan AF. A PI3K pathway mediates hair cell survival and opposes gentamicin toxicity in neonatal rat organ of Corti. J Assoc Res Otolaryngol. 2006 Dec; 7(4):373-82. PMID: 17053865; PMCID: PMC2504631.
    51. Paul S, Dansithong W, Kim D, Rossi J, Webster NJ, Comai L, Reddy S. Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing. EMBO J. 2006 Sep 20; 25(18):4271-83. PMID: 16946708; PMCID: PMC1570429.
    52. Matsushima R, Harada N, Webster NJ, Tsutsumi YM, Nakaya Y. Effect of TRB3 on insulin and nutrient-stimulated hepatic p70 S6 kinase activity. J Biol Chem. 2006 Oct 06; 281(40):29719-29. PMID: 16887816.
      View in: PubMed
    53. Zhang H, Bailey JS, Coss D, Lin B, Tsutsumi R, Lawson MA, Mellon PL, Webster NJ. Activin modulates the transcriptional response of LbetaT2 cells to gonadotropin-releasing hormone and alters cellular proliferation. Mol Endocrinol. 2006 Nov; 20(11):2909-30. PMID: 16772531; PMCID: PMC2673912.
    54. Liu F, Ruiz MS, Austin DA, Webster NJ. Constitutively active Gq impairs gonadotropin-releasing hormone-induced intracellular signaling and luteinizing hormone secretion in LbetaT2 cells. Mol Endocrinol. 2005 Aug; 19(8):2074-85. PMID: 15878957.
      View in: PubMed
    55. Pirrung MC, Liu Y, Deng L, Halstead DK, Li Z, May JF, Wedel M, Austin DA, Webster NJ. Methyl scanning: total synthesis of demethylasterriquinone B1 and derivatives for identification of sites of interaction with and isolation of its receptor(s). J Am Chem Soc. 2005 Apr 06; 127(13):4609-24. PMID: 15796526.
      View in: PubMed
    56. Palacios SD, Pak K, Rivkin AZ, Kayali AG, Austen D, Aletsee C, Melhus A, Webster NJ, Ryan AF. Role of p38 mitogen-activated protein kinase in middle ear mucosa hyperplasia during bacterial otitis media. Infect Immun. 2004 Aug; 72(8):4662-7. PMID: 15271927; PMCID: PMC470656.
    57. Webster NJ, Evans LG, Caples M, Erker L, Chew SL. Assembly of splicing complexes on exon 11 of the human insulin receptor gene does not correlate with splicing efficiency in-vitro. BMC Mol Biol. 2004 Jul 02; 5:7. PMID: 15233842; PMCID: PMC481066.
    58. Liu F, Austin DA, Webster NJ. Gonadotropin-releasing hormone-desensitized LbetaT2 gonadotrope cells are refractory to acute protein kinase C, cyclic AMP, and calcium-dependent signaling. Endocrinology. 2003 Oct; 144(10):4354-65. PMID: 12960037.
      View in: PubMed
    59. Webster NJ, Park K, Pirrung MC. Signaling effects of demethylasterriquinone B1, a selective insulin receptor modulator. Chembiochem. 2003 May 09; 4(5):379-85. PMID: 12740809.
      View in: PubMed
    60. Palacios SD, Pak K, Kayali AG, Rivkin AZ, Aletsee C, Melhus A, Webster NJ, Ryan AF. Participation of Ras and extracellular regulated kinase in the hyperplastic response of middle-ear mucosa during bacterial otitis media. J Infect Dis. 2002 Dec 15; 186(12):1761-9. PMID: 12447762.
      View in: PubMed
    61. Kayali AG, Austin DA, Webster NJ. Rottlerin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes by uncoupling mitochondrial oxidative phosphorylation. Endocrinology. 2002 Oct; 143(10):3884-96. PMID: 12239100.
      View in: PubMed
    62. Vasilyev VV, Lawson MA, Dipaolo D, Webster NJ, Mellon PL. Different signaling pathways control acute induction versus long-term repression of LHbeta transcription by GnRH. Endocrinology. 2002 Sep; 143(9):3414-26. PMID: 12193554; PMCID: PMC2932485.
    63. Lorenzo M, Teruel T, Hernandez R, Kayali AG, Webster NJ. PLCgamma participates in insulin stimulation of glucose uptake through activation of PKCzeta in brown adipocytes. Exp Cell Res. 2002 Aug 15; 278(2):146-57. PMID: 12169270.
      View in: PubMed
    64. Liu F, Usui I, Evans LG, Austin DA, Mellon PL, Olefsky JM, Webster NJ. Involvement of both G(q/11) and G(s) proteins in gonadotropin-releasing hormone receptor-mediated signaling in L beta T2 cells. J Biol Chem. 2002 Aug 30; 277(35):32099-108. PMID: 12050161; PMCID: PMC2930616.
    65. Seely BL, Samimi G, Webster NJ. Retroviral expression of a kinase-defective IGF-I receptor suppresses growth and causes apoptosis of CHO and U87 cells in-vivo. BMC Cancer. 2002 May 31; 2:15. PMID: 12057025; PMCID: PMC115841.
    66. Vasilyev VV, Pernasetti F, Rosenberg SB, Barsoum MJ, Austin DA, Webster NJ, Mellon PL. Transcriptional activation of the ovine follicle-stimulating hormone-beta gene by gonadotropin-releasing hormone involves multiple signal transduction pathways. Endocrinology. 2002 May; 143(5):1651-9. PMID: 11956146; PMCID: PMC2930615.
    67. Liu F, Austin DA, Mellon PL, Olefsky JM, Webster NJ. GnRH activates ERK1/2 leading to the induction of c-fos and LHbeta protein expression in LbetaT2 cells. Mol Endocrinol. 2002 Mar; 16(3):419-34. PMID: 11875099.
      View in: PubMed
    68. Eichhorn J, Kayali AG, Resor L, Austin DA, Rose DW, Webster NJ. PLC-gamma1 enzyme activity is required for insulin-induced DNA synthesis. Endocrinology. 2002 Feb; 143(2):655-64. PMID: 11796522.
      View in: PubMed
    69. Ramsden M, Plant LD, Webster NJ, Vaughan PF, Henderson Z, Pearson HA. Differential effects of unaggregated and aggregated amyloid beta protein (1-40) on K(+) channel currents in primary cultures of rat cerebellar granule and cortical neurones. J Neurochem. 2001 Nov; 79(3):699-712. PMID: 11701773.
      View in: PubMed
    70. Webster NJ, Vaughan PF, Peers C. Hypoxic enhancement of evoked noradrenaline release from the human neuroblastoma SH-SY5Y. Brain Res Mol Brain Res. 2001 Apr 18; 89(1-2):50-7. PMID: 11311975.
      View in: PubMed
    71. Eichhorn J, Kayali AG, Austin DA, Webster NJ. Insulin activates phospholipase C-gamma1 via a PI-3 kinase dependent mechanism in 3T3-L1 adipocytes. Biochem Biophys Res Commun. 2001 Mar 30; 282(2):615-20. PMID: 11401505.
      View in: PubMed
    72. Roberts DJ, Khan N, McDonald RL, Webster NJ, Peers C, Vaughan PF. Inhibition of depolarisation-evoked [(3)H]noradrenaline release from SH-SYFY human neuroblastoma cells by muscarinic (M1) receptors is not mediated by changes in [Ca(2+)]. Brain Res Mol Brain Res. 2001 Feb 19; 87(1):81-91. PMID: 11223162.
      View in: PubMed
    73. Kayali AG, Austin DA, Webster NJ. Stimulation of MAPK cascades by insulin and osmotic shock: lack of an involvement of p38 mitogen-activated protein kinase in glucose transport in 3T3-L1 adipocytes. Diabetes. 2000 Nov; 49(11):1783-93. PMID: 11078444.
      View in: PubMed
    74. Park KS, Ciaraldi TP, Carter L, Mudaliar S, Nikoulina SE, Webster NJ, Henry RR. Induction of insulin resistance in human skeletal muscle cells by downregulation of glycogen synthase protein expression. Metabolism. 2000 Aug; 49(8):962-8. PMID: 10954011.
      View in: PubMed
    75. Zapf-Colby A, Eichhorn J, Webster NJ, Olefsky JM. Inhibition of PLC-gamma1 activity converts nerve growth factor from an anti-mitogenic to a mitogenic signal in CHO cells. Oncogene. 1999 Sep 02; 18(35):4908-19. PMID: 10490825.
      View in: PubMed
    76. Webster NJ, Huang Z. Hormonal regulation of alternative splicing. Front Horm Res. 1999; 25:1-17. PMID: 10941399.
      View in: PubMed
    77. Kayali AG, Eichhorn J, Haruta T, Morris AJ, Nelson JG, Vollenweider P, Olefsky JM, Webster NJ. Association of the insulin receptor with phospholipase C-gamma (PLCgamma) in 3T3-L1 adipocytes suggests a role for PLCgamma in metabolic signaling by insulin. J Biol Chem. 1998 May 29; 273(22):13808-18. PMID: 9593725.
      View in: PubMed
    78. Kosaki A, Nelson J, Webster NJ. Identification of intron and exon sequences involved in alternative splicing of insulin receptor pre-mRNA. J Biol Chem. 1998 Apr 24; 273(17):10331-7. PMID: 9553088.
      View in: PubMed
    79. Resnik JL, Reichart DB, Huey K, Webster NJ, Seely BL. Elevated insulin-like growth factor I receptor autophosphorylation and kinase activity in human breast cancer. Cancer Res. 1998 Mar 15; 58(6):1159-64. PMID: 9515800.
      View in: PubMed
    80. Webster NJ, Kong Y, Sharma P, Haas M, Sukumar S, Seely BL. Differential effects of Wilms tumor WT1 splice variants on the insulin receptor promoter. Biochem Mol Med. 1997 Dec; 62(2):139-50. PMID: 9441865.
      View in: PubMed
    81. Webster NJ, Resnik JL, Reichart DB, Strauss B, Haas M, Seely BL. Repression of the insulin receptor promoter by the tumor suppressor gene product p53: a possible mechanism for receptor overexpression in breast cancer. Cancer Res. 1996 Jun 15; 56(12):2781-8. PMID: 8665514.
      View in: PubMed
    82. Huang Z, Bodkin NL, Ortmeyer HK, Zenilman ME, Webster NJ, Hansen BC, Shuldiner AR. Altered insulin receptor messenger ribonucleic acid splicing in liver is associated with deterioration of glucose tolerance in the spontaneously obese and diabetic rhesus monkey: analysis of controversy between monkey and human studies. J Clin Endocrinol Metab. 1996 Apr; 81(4):1552-6. PMID: 8636366.
      View in: PubMed
    83. Nur T, Sela I, Webster NJ, Madar Z. Starvation and refeeding regulate glycogen synthase gene expression in rat liver at the posttranscriptional level. J Nutr. 1995 Oct; 125(10):2457-62. PMID: 7562079.
      View in: PubMed
    84. Kosaki A, Pillay TS, Xu L, Webster NJ. The B isoform of the insulin receptor signals more efficiently than the A isoform in HepG2 cells. J Biol Chem. 1995 Sep 01; 270(35):20816-23. PMID: 7657666.
      View in: PubMed
    85. Wu H, Mahata SK, Mahata M, Webster NJ, Parmer RJ, O'Connor DT. A functional cyclic AMP response element plays a crucial role in neuroendocrine cell type-specific expression of the secretory granule protein chromogranin A. J Clin Invest. 1995 Jul; 96(1):568-78. PMID: 7615829; PMCID: PMC185231.
    86. Wu H, Rozansky DJ, Webster NJ, O'Connor DT. Cell type-specific gene expression in the neuroendocrine system. A neuroendocrine-specific regulatory element in the promoter of chromogranin A, a ubiquitous secretory granule core protein. J Clin Invest. 1994 Jul; 94(1):118-29. PMID: 8040254; PMCID: PMC296289.
    87. Webster NJ, Kong Y, Cameron KE, Resnik JL. An upstream element from the human insulin receptor gene promoter contains binding sites for C/EBP beta and NF-1. Diabetes. 1994 Feb; 43(2):305-12. PMID: 8288055.
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    88. Rolband GC, Williams JF, Webster NJ, Hsu D, Olefsky JM. Deletion of exon 21 of the insulin receptor eliminates tyrosine kinase activity but preserves mitogenic signaling. Biochemistry. 1993 Dec 14; 32(49):13545-50. PMID: 8257690.
      View in: PubMed
    89. Kosaki A, Webster NJ. Effect of dexamethasone on the alternative splicing of the insulin receptor mRNA and insulin action in HepG2 hepatoma cells. J Biol Chem. 1993 Oct 15; 268(29):21990-6. PMID: 8408055.
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    90. Kaliman P, Baron V, Alengrin F, Takata Y, Webster NJ, Olefsky JM, Van Obberghen E. The insulin receptor C-terminus is involved in regulation of the receptor kinase activity. Biochemistry. 1993 Sep 21; 32(37):9539-44. PMID: 7690586.
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    91. Rolband GC, Williams JF, Webster NJ, Olefsky JM. Deletion of the insulin receptor beta-subunit acidic domain results in enhanced metabolic signaling. Endocrinology. 1993 Sep; 133(3):1437-43. PMID: 8396020.
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    92. Anderson CM, Henry RR, Knudson PE, Olefsky JM, Webster NJ. Relative expression of insulin receptor isoforms does not differ in lean, obese, and noninsulin-dependent diabetes mellitus subjects. J Clin Endocrinol Metab. 1993 May; 76(5):1380-2. PMID: 7684396.
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    93. Cameron KE, Resnik J, Webster NJ. Transcriptional regulation of the human insulin receptor promoter. J Biol Chem. 1992 Aug 25; 267(24):17375-83. PMID: 1324934.
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    94. Takata Y, Webster NJ, Olefsky JM. Intracellular signaling by a mutant human insulin receptor lacking the carboxyl-terminal tyrosine autophosphorylation sites. J Biol Chem. 1992 May 05; 267(13):9065-70. PMID: 1577744.
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    95. Takata Y, Webster NJ, Olefsky JM. Mutation of the two carboxyl-terminal tyrosines results in an insulin receptor with normal metabolic signaling but enhanced mitogenic signaling properties. J Biol Chem. 1991 May 15; 266(14):9135-9. PMID: 2026614.
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    96. Thies RS, Webster NJ, McClain DA. A domain of the insulin receptor required for endocytosis in rat fibroblasts. J Biol Chem. 1990 Jun 15; 265(17):10132-7. PMID: 2161833.
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    97. Webster NJ, Green S, Tasset D, Ponglikitmongkol M, Chambon P. The transcriptional activation function located in the hormone-binding domain of the human oestrogen receptor is not encoded in a single exon. EMBO J. 1989 May; 8(5):1441-6. PMID: 2767048; PMCID: PMC400972.
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