MARY ESTES

TitleDistinguished Service Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Virology & Microbiology
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleDistinguished Service Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-Gastroenterology & Hepatol

    TitleDistinguished Service Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine
    DivisionMedicine-Infectious Disease


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    Collapse Biography 
    Collapse awards and honors
    1966 - 1967Beta Beta Beta
    1967Biology Award, Elmira College
    1974American Cancer Society Postdoctoral Fellowship (declined)
    1974 - 1976National Institutes of Health Postdoctoral Fellowship
    1987 - 1988ASM Foundation for Microbiology, Lecturer in Virology
    1992Wallace P. Rowe Award for Excellence in Virologic Research
    1992 - 1994ASM Foundation for Microbiology, Lecturer in Virology
    1994 - 2003Editor, Journal of Virology
    19951995 Michael E. DeBakey Award for Outstanding Research
    19961996 Elected Fellow, American Academy of Microbiology
    1996 - 1997President, American Society for Virology
    20002000 Elected Fellow, American Association for the Advancement of Science
    2000Researcher/Investigator of the Year, Crohn’s & Colitis Foundation Gold Key Award
    2005Elected Member, Institute of Medicine, National Academy of Science
    2005Member, Academy of Medicine, Engineering and Science of Texas
    2006Cullen Foundation Endowed Chair of Human and Molecular Virology
    2007Elected Member, National Academy of Sciences
    2007Associate Editor, PLoS Pathogens
    2009Distinguished Faculty Award, Baylor College of Medicine
    2009mBio Board of Editors
    2010Distinguished Service Professor, Baylor College of Medicine
    2010AGA Distinguished Achievement Award
    2011 - 2013Co-Editor in Chief, Current Opinion in Virology
    2011Elected Fellow, American Gastroenterological Association

    Collapse Overview 
    Collapse overview
    Molecular Biology of Gastrointestinal Viruses

    The gastrointestinal (GI) tract represents the largest and most heterogeneous organ in the body. However, information on the molecular biology of most cell types in the GI tract remains limited. We are using viruses that infect distinct types of cells (enterocytes, crypt cells, M cells) in the GI tract as probes to learn about the biology, host response and gene expression of these cells. We are using multidisciplinary approaches to probe the structure and molecular biology of GI viruses to understand the basic mechanisms that control virus replication, morphogenesis, virus-host interactions, and pathogenesis.

    Our work uses two viruses, rotaviruses, the major cause of diarrhea in children and animals worldwide, and human caliciviruses, the major cause of epidemic gastroenteritis. Studies on the molecular biology of the rotaviruses seek to dissect the biologic, biochemical and structural role(s) inducing disease. Current studies are focusing on the rotavirus spike protein and the viral enterotoxin and how these proteins induce signaling pathways in cells that are important in immunity and pathogenesis. We are studying proteins expressed from inducible cDNAs in mammalian cells and virus-like particles (VLPs) produced using the baculovirus expression system. We aim to determine how specific domains of the viral proteins interact with intestinal cell receptors, affect cell signaling mechan-isms, and induce diarrhea. We also are evaluating how to effectively orally deliver virus-like particlesubunit vaccines to induce a mucosal immune response and protection from virus infection.

    Studies on the human caliciviruses are using molecular approaches to characterize Norwalk virus and related viruses. Sequence analysis and expression of genes from a cloned DNA library of Norwalk virus nucleic acid have classified this virus, determined its genome organization and relatedness to other Norwalk-like viruses and other gastroenteritis viruses such as astroviruses and enteroviruses, and produced new diagnostic assays. Use of these new assays is changing our understanding of the natural history and epidemiology of infections with these viruses. Notably, these viruses are being increasingly recognized as important causes of disease in children and in immunocompromised individuals. Expression of the capsid protein using mammalian and plant VLPs allowed the first crystallographic structure of a calicivirus to be solved and they are being tested directly as mucosal vaccines or as delivery systems for vaccines containing epitopes from other pathogens. Finally, the molecular basis of the restricted replication of Norwalk viruses to the gastrointestinal tract of humans is being probed by expression of Norwalk virus genes with different vectors and testing the interactions of virus with different cell lines and tissues derived from the gastrointestinal tract.

    Collapse Research 
    Collapse research activities and funding
    R01AM030144     (ESTES, MARY KOLB)Aug 1, 1981 - Jul 31, 1989
    NIH/NIADDK
    MOLECULAR BIOLOGY OF THE ROTAVIRUSES
    Role: Principal Investigator

    R01DK030144     (ESTES, MARY KOLB)Aug 1, 1981 - Jun 30, 2006
    NIH/NIDDK
    MOLECULAR BIOLOGY OF THE ROTAVIRUSES
    Role: Principal Investigator

    R56DK030144     (ESTES, MARY KOLB)Aug 1, 1981 - Jun 30, 2009
    NIH/NIDDK
    Molecular Biology of the Rotaviruses
    Role: Principal Investigator

    R22AI020649     (ESTES, MARY KOLB)Sep 30, 1984 - Jul 31, 1991
    NIH/NIAID
    ANTIGENIC VARIATION OF HUMAN ROTAVIRUSES
    Role: Principal Investigator

    R01AI020649     (ESTES, MARY KOLB)Sep 30, 1984 - Nov 30, 1992
    NIH/NIAID
    ANTIGENIC VARIATION OF HUMAN ROTAVIRUSES
    Role: Principal Investigator

    R01AI024998     (CONNER, MARGARET E.)Jul 1, 1987 - Sep 30, 2010
    NIH/NIAID
    Intestinal Mucosal Immunity
    Role: Co-Principal Investigator

    U01AI030448     (ESTES, MARY KOLB)Jul 1, 1990 - Jun 30, 1995
    NIH/NIAID
    DEVELOPMENT OF DIAGNOSTIC TESTS FOR NORWALK VIRUSES
    Role: Principal Investigator

    R13AI030488     (ESTES, MARY KOLB)Dec 1, 1990 - Nov 30, 1991
    NIH/NIAID
    INTERNATIONAL SYMPOSIUM ON DOUBLE-STRANDED RNA VIRUSES
    Role: Principal Investigator

    U01AI038036     (ESTES, MARY KOLB)Jul 1, 1995 - Jun 30, 1999
    NIH/NIAID
    STRUCTURE DIRECTED ANTIVIRAL STRATEGIES FOR CALICIVIRUSE
    Role: Principal Investigator

    R21AI042646     (ESTES, MARY KOLB)Sep 30, 1997 - Sep 29, 2000
    NIH/NIAID
    MUCOSAL VACCINE FOR HIV
    Role: Principal Investigator

    R01AI046581     (ESTES, MARY KOLB)Jan 15, 2000 - Dec 31, 2004
    NIH/NIAID
    MOLECULAR AND ANTIGENIC ANALYSIS OF HUMAN CALICIVIRUS
    Role: Principal Investigator

    P30DK056338     (EL-SERAG, HASHEM B)Apr 15, 2001 - May 31, 2012
    NIH/NIDDK
    Texas Medical Center Digestive Diseases Center
    Role: Co-Principal Investigator

    T32AI055413     (ATMAR, ROBERT L.)Aug 1, 2003 - May 31, 2019
    NIH/NIAID
    Research Training in Infection and Immunity
    Role: Co-Principal Investigator

    P01AI057788     (ESTES, MARY KOLB)Dec 1, 2003 - Sep 30, 2011
    NIH/NIAID
    Mechanisms of Norovirus Pathogenesis and Replication to Develop Therapeutics
    Role: Principal Investigator

    R03TW007764     (ESTES, MARY KOLB)Jul 1, 2007 - Apr 30, 2011
    NIH/FIC
    CALICIVIRAL INFECTIONS AND DISEASE IN SOUTHERN INDIA
    Role: Principal Investigator

    R56AI080656     (ESTES, MARY KOLB)Dec 1, 2008 - Jul 31, 2015
    NIH/NIAID
    Regulation of Rotavirus Replication
    Role: Principal Investigator

    R01AI080656     (ESTES, MARY KOLB)Aug 11, 2009 - Jul 31, 2014
    NIH/NIAID
    Regulation of Rotavirus Replication
    Role: Principal Investigator

    T32GM088129     (VAN DEN VEYVER, IGNATIA B)Jul 1, 2010 - Jun 30, 2020
    NIH/NIGMS
    Training Program in Translational Biology and Molecular Medicine
    Role: Co-Principal Investigator

    R01AI105101     (ESTES, MARY KOLB)Jul 1, 2013 - Jun 30, 2017
    NIH/NIAID
    Intestinal and Milk Glycan Expression in Restriction of Neonatal Infection
    Role: Principal Investigator

    U01DK103168     (ESTES, MARY KOLB)Sep 5, 2014 - Aug 31, 2024
    NIH/NIDDK
    Intestinal Niche in Homeostasis and Epithelial Regeneration
    Role: Principal Investigator

    U19AI116497     (ESTES, MARY KOLB)Mar 15, 2015 - Feb 29, 2020
    NIH/NIAID
    Engineering Novel Enteroid Models for Understanding Human Enteric Disease
    Role: Principal Investigator

    S10OD028480     (ESTES, MARY KOLB)Aug 15, 2020 - Aug 14, 2021
    NIH
    Confocal Microscope (Zeiss LSM980 with Airyscan 2)
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wilson RL, Hewes SA, Rajan A, Lin SC, Bomidi C, Iida T, Estes MK, Maresso AW, Grande-Allen KJ. A Millifluidic Perfusion Cassette for Studying the Pathogenesis of Enteric Infections Using Ex-Vivo Organoids. Ann Biomed Eng. 2021 Jan 06. PMID: 33409849.
      Citations:    Fields:    
    2. Wilson RL, Swaminathan G, Ettayebi K, Bomidi C, Zeng XL, Blutt SE, Estes MK, Grande-Allen KJ. Protein-functionalized poly(ethylene glycol) hydrogels as scaffolds for monolayer organoid culture. Tissue Eng Part C Methods. 2020 Dec 17. PMID: 33334213.
      Citations:    Fields:    
    3. Huang W, Soeung V, Boragine DM, Hu L, Prasad BVV, Estes MK, Atmar RL, Palzkill T. High-Resolution Mapping of Human Norovirus Antigens via Genomic Phage Display Library Selections and Deep Sequencing. J Virol. 2020 Dec 09; 95(1). PMID: 33055250.
      Citations:    Fields:    
    4. Hasan NM, Johnson KF, Yin J, Baetz NW, Fayad L, Sherman V, Blutt SE, Estes MK, Kumbhari V, Zachos NC, Kovbasnjuk O. Intestinal stem cell-derived enteroids from morbidly obese patients preserve obesity-related phenotypes: Elevated glucose absorption and gluconeogenesis. Mol Metab. 2020 Nov 25; 44:101129. PMID: 33246140.
      Citations:    Fields:    
    5. Chang-Graham AL, Perry JL, Engevik MA, Engevik KA, Scribano FJ, Gebert JT, Danhof HA, Nelson JC, Kellen JS, Strtak AC, Sastri NP, Estes MK, Britton RA, Versalovic J, Hyser JM. Rotavirus induces intercellular calcium waves through ADP signaling. Science. 2020 11 20; 370(6519). PMID: 33214249.
      Citations:    Fields:    
    6. Engevik M, Danhof HA, Auchtung J, Endres BT, Ruan W, Bassères E, Engevik AC, Wu Q, Nicholson M, Luna RA, Garey KW, Crawford SE, Estes MK, Lux R, Yacyshyn MB, Yacyshyn B, Savidge T, Britton RA, Versalovic J. Fusobacterium nucleatum adheres to Clostridioides difficile via the RadD adhesin to enhance biofilm formation in intestinal mucus. Gastroenterology. 2020 Nov 20. PMID: 33227279.
      Citations:    Fields:    
    7. Criglar JM, Crawford SE, Estes MK. Plasmid-based reverse genetics for probing phosphorylation-dependent viroplasm formation in rotaviruses. Virus Res. 2021 Jan 02; 291:198193. PMID: 33053412.
      Citations:    Fields:    
    8. Rajan A, Robertson MJ, Carter HE, Poole NM, Clark JR, Green SI, Criss ZK, Zhao B, Karandikar U, Xing Y, Margalef-Català M, Jain N, Wilson RL, Bai F, Hyser JM, Petrosino J, Shroyer NF, Blutt SE, Coarfa C, Song X, Prasad BV, Amieva MR, Grande-Allen J, Estes MK, Okhuysen PC, Maresso AW. Enteroaggregative E. coli Adherence to Human Heparan Sulfate Proteoglycans Drives Segment and Host Specific Responses to Infection. PLoS Pathog. 2020 09; 16(9):e1008851. PMID: 32986782.
      Citations:    Fields:    Translation:HumansCells
    9. In JG, Yin J, Atanga R, Doucet M, Cole RN, DeVine L, Donowitz M, Zachos NC, Blutt SE, Estes MK, Kovbasnjuk O. Epithelial WNT2B and Desert Hedgehog Are Necessary for Human Colonoid Regeneration after Bacterial Cytotoxin Injury. iScience. 2020 Oct 23; 23(10):101618. PMID: 33089106.
      Citations:    
    10. Chakravarti D, Hu B, Mao X, Rashid A, Li J, Li J, Liao WT, Whitley EM, Dey P, Hou P, LaBella KA, Chang A, Wang G, Spring DJ, Deng P, Zhao D, Liang X, Lan Z, Lin Y, Sarkar S, Terranova C, Deribe YL, Blutt SE, Okhuysen P, Zhang J, Vilar E, Nielsen OH, Dupont A, Younes M, Patel KR, Shroyer NF, Rai K, Estes MK, Wang YA, Bertuch AA, DePinho RA. Telomere dysfunction activates YAP1 to drive tissue inflammation. Nat Commun. 2020 09 21; 11(1):4766. PMID: 32958778.
      Citations:    Fields:    Translation:HumansAnimalsCells
    11. Olvera A, Carter H, Rajan A, Carlin LG, Yu X, Zeng XL, Shelburne S, Bhatti M, Blutt SE, Shroyer NF, Jenq R, Estes MK, Maresso A, Okhuysen PC. Enteropathogenic Escherichia coli Infection in Cancer and Immunosuppressed Patients. Clin Infect Dis. 2020 Sep 15. PMID: 32930708.
      Citations:    Fields:    
    12. Rimkute I, Thorsteinsson K, Henricsson M, Tenge VR, Yu X, Lin SC, Haga K, Atmar RL, Lycke N, Nilsson J, Estes MK, Bally M, Larson G. Histo-blood group antigens of glycosphingolipids predict susceptibility of human intestinal enteroids to norovirus infection. J Biol Chem. 2020 Nov 20; 295(47):15974-15987. PMID: 32913124.
      Citations:    Fields:    
    13. Lin SC, Qu L, Ettayebi K, Crawford SE, Blutt SE, Robertson MJ, Zeng XL, Tenge VR, Ayyar BV, Karandikar UC, Yu X, Coarfa C, Atmar RL, Ramani S, Estes MK. Human norovirus exhibits strain-specific sensitivity to host interferon pathways in human intestinal enteroids. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23782-23793. PMID: 32907944.
      Citations:    Fields:    Translation:HumansCells
    14. Criglar JM, Crawford SE, Zhao B, Smith HG, Stossi F, Estes MK. A Genetically Engineered Rotavirus NSP2 Phosphorylation Mutant Impaired in Viroplasm Formation and Replication Shows an Early Interaction between vNSP2 and Cellular Lipid Droplets. J Virol. 2020 07 16; 94(15). PMID: 32461314.
      Citations:    Fields:    Translation:AnimalsCells
    15. Kumar D, Yu X, Crawford SE, Moreno R, Jakana J, Sankaran B, Anish R, Kaundal S, Hu L, Estes MK, Wang Z, Prasad BVV. 2.7 Å cryo-EM structure of rotavirus core protein VP3, a unique capping machine with a helicase activity. Sci Adv. 2020 Apr; 6(16):eaay6410. PMID: 32494598.
      Citations:    Fields:    
    16. Graziano VR, Walker FC, Kennedy EA, Wei J, Ettayebi K, Strine MS, Filler RB, Hassan E, Hsieh LL, Kim AS, Kolawole AO, Wobus CE, Lindesmith LC, Baric RS, Estes MK, Orchard RC, Baldridge MT, Wilen CB. CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus. PLoS Pathog. 2020 04; 16(4):e1008242. PMID: 32251490.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    17. Hewes SA, Wilson RL, Estes MK, Shroyer NF, Blutt SE, Grande-Allen KJ. In Vitro Models of the Small Intestine: Engineering Challenges and Engineering Solutions. Tissue Eng Part B Rev. 2020 08; 26(4):313-326. PMID: 32046599.
      Citations: 1     Fields:    
    18. Haga K, Ettayebi K, Tenge VR, Karandikar UC, Lewis MA, Lin SC, Neill FH, Ayyar BV, Zeng XL, Larson G, Ramani S, Atmar RL, Estes MK. Genetic Manipulation of Human Intestinal Enteroids Demonstrates the Necessity of a Functional Fucosyltransferase 2 Gene for Secretor-Dependent Human Norovirus Infection. mBio. 2020 03 17; 11(2). PMID: 32184242.
      Citations: 6     Fields:    
    19. Atmar RL, Ettayebi K, Ayyar BV, Neill FH, Braun RP, Ramani S, Estes MK. Comparison of Microneutralization and Histo-Blood Group Antigen-Blocking Assays for Functional Norovirus Antibody Detection. J Infect Dis. 2020 02 18; 221(5):739-743. PMID: 31613328.
      Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
    20. Murakami K, Tenge VR, Karandikar UC, Lin SC, Ramani S, Ettayebi K, Crawford SE, Zeng XL, Neill FH, Ayyar BV, Katayama K, Graham DY, Bieberich E, Atmar RL, Estes MK. Bile acids and ceramide overcome the entry restriction for GII.3 human norovirus replication in human intestinal enteroids. Proc Natl Acad Sci U S A. 2020 01 21; 117(3):1700-1710. PMID: 31896578.
      Citations: 11     Fields:    Translation:HumansCells
    21. Stewart CJ, Estes MK, Ramani S. Establishing Human Intestinal Enteroid/Organoid Lines from Preterm Infant and Adult Tissue. Methods Mol Biol. 2020; 2121:185-198. PMID: 32147796.
      Citations:    Fields:    
    22. Cardenas D, Bhalchandra S, Lamisere H, Chen Y, Zeng XL, Ramani S, Karandikar UC, Kaplan DL, Estes MK, Ward HD. Two- and Three-Dimensional Bioengineered Human Intestinal Tissue Models for Cryptosporidium. Methods Mol Biol. 2020; 2052:373-402. PMID: 31452173.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    23. Crawford SE, Criglar JM, Liu Z, Broughman JR, Estes MK. COPII Vesicle Transport Is Required for Rotavirus NSP4 Interaction with the Autophagy Protein LC3 II and Trafficking to Viroplasms. J Virol. 2019 12 12; 94(1). PMID: 31597778.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    24. Blutt SE, Estes MK. Gut Bacterial Bouncers: Keeping Viral Pathogens out of the Epithelium. . 2019 11 13; 26(5):569-570. PMID: 31726023.
      Citations:    
    25. Vinjé J, Estes MK, Esteves P, Green KY, Katayama K, Knowles NJ, L'Homme Y, Martella V, Vennema H, White PA. ICTV Virus Taxonomy Profile: Caliciviridae. J Gen Virol. 2019 11; 100(11):1469-1470. PMID: 31573467.
      Citations: 7     Fields:    Translation:AnimalsCells
    26. Engevik MA, Morra CN, Röth D, Engevik K, Spinler JK, Devaraj S, Crawford SE, Estes MK, Kalkum M, Versalovic J. Microbial Metabolic Capacity for Intestinal Folate Production and Modulation of Host Folate Receptors. Front Microbiol. 2019; 10:2305. PMID: 31649646.
      Citations:    
    27. Blutt SE, Klein OD, Donowitz M, Shroyer N, Guha C, Estes MK. Use of organoids to study regenerative responses to intestinal damage. Am J Physiol Gastrointest Liver Physiol. 2019 12 01; 317(6):G845-G852. PMID: 31589468.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    28. Chan MC, Cheung SKC, Mohammad KN, Chan JCM, Estes MK, Chan PKS. Use of Human Intestinal Enteroids to Detect ?Human Norovirus Infectivity. Emerg Infect Dis. 2019 09; 25(9):1730-1735. PMID: 31441758.
      Citations: 3     Fields:    Translation:HumansCells
    29. Tapia R, Perez-Yepez EA, Carlino MJ, Karandikar UC, Kralicek SE, Estes MK, Hecht GA. Sperm Flagellar 1 Binds Actin in Intestinal Epithelial Cells and Contributes to Formation of Filopodia and Lamellipodia. Gastroenterology. 2019 12; 157(6):1544-1555.e3. PMID: 31473225.
      Citations:    Fields:    Translation:HumansAnimalsCells
    30. Fasciano AC, Blutt SE, Estes MK, Mecsas J. Induced Differentiation of M Cell-like Cells in Human Stem Cell-derived Ileal Enteroid Monolayers. J Vis Exp. 2019 07 26; (149). PMID: 31403623.
      Citations: 3     Fields:    Translation:HumansCells
    31. Chang-Graham AL, Perry JL, Strtak AC, Ramachandran NK, Criglar JM, Philip AA, Patton JT, Estes MK, Hyser JM. Rotavirus Calcium Dysregulation Manifests as Dynamic Calcium Signaling in the Cytoplasm and Endoplasmic Reticulum. Sci Rep. 2019 07 25; 9(1):10822. PMID: 31346185.
      Citations: 6     Fields:    Translation:HumansCells
    32. Estes MK, Ettayebi K, Tenge VR, Murakami K, Karandikar U, Lin SC, Ayyar BV, Cortes-Penfield NW, Haga K, Neill FH, Opekun AR, Broughman JR, Zeng XL, Blutt SE, Crawford SE, Ramani S, Graham DY, Atmar RL. Human Norovirus Cultivation in Nontransformed Stem Cell-Derived Human Intestinal Enteroid Cultures: Success and Challenges. Viruses. 2019 07 11; 11(7). PMID: 31336765.
      Citations: 8     Fields:    Translation:HumansCells
    33. Chang-Graham AL, Danhof HA, Engevik MA, Tomaro-Duchesneau C, Karandikar UC, Estes MK, Versalovic J, Britton RA, Hyser JM. Human Intestinal Enteroids With Inducible Neurogenin-3 Expression as a Novel Model of Gut Hormone Secretion. Cell Mol Gastroenterol Hepatol. 2019; 8(2):209-229. PMID: 31029854.
      Citations: 14     Fields:    Translation:HumansCells
    34. Uotani T, Murakami K, Uchida T, Tanaka S, Nagashima H, Zeng XL, Akada J, Estes MK, Graham DY, Yamaoka Y. Changes of tight junction and interleukin-8 expression using a human gastroid monolayer model of Helicobacter pylori infection. Helicobacter. 2019 Jun; 24(3):e12583. PMID: 30950121.
      Citations: 1     Fields:    Translation:HumansCells
    35. Viskovska MA, Zhao B, Shanker S, Choi JM, Deng L, Song Y, Palzkill T, Hu L, Estes MK, Venkataram Prasad BV. GII.4 Norovirus Protease Shows pH-Sensitive Proteolysis with a Unique Arg-His Pairing in the Catalytic Site. J Virol. 2019 03 15; 93(6). PMID: 30626675.
      Citations: 3     Fields:    Translation:HumansCells
    36. Zou WY, Blutt SE, Crawford SE, Ettayebi K, Zeng XL, Saxena K, Ramani S, Karandikar UC, Zachos NC, Estes MK. Human Intestinal Enteroids: New Models to Study Gastrointestinal Virus Infections. Methods Mol Biol. 2019; 1576:229-247. PMID: 28361480.
      Citations: 32     Fields:    Translation:HumansCells
    37. Criglar JM, Anish R, Hu L, Crawford SE, Sankaran B, Prasad BVV, Estes MK. Phosphorylation cascade regulates the formation and maturation of rotaviral replication factories. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):E12015-E12023. PMID: 30509975.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    38. Ramani S, Stewart CJ, Laucirica DR, Ajami NJ, Robertson B, Autran CA, Shinge D, Rani S, Anandan S, Hu L, Ferreon JC, Kuruvilla KA, Petrosino JF, Venkataram Prasad BV, Bode L, Kang G, Estes MK. Human milk oligosaccharides, milk microbiome and infant gut microbiome modulate neonatal rotavirus infection. Nat Commun. 2018 11 27; 9(1):5010. PMID: 30479342.
      Citations: 15     Fields:    Translation:HumansCells
    39. Atmar RL, Ramani S, Estes MK. Human noroviruses: recent advances in a 50-year history. Curr Opin Infect Dis. 2018 10; 31(5):422-432. PMID: 30102614.
      Citations: 19     Fields:    Translation:HumansCells
    40. Liang H, Estes MK, Zhang H, Du G, Zhou Y. Bile acids target proteolipid nano-assemblies of EGFR and phosphatidic acid in the plasma membrane for stimulation of MAPK signaling. PLoS One. 2018; 13(8):e0198983. PMID: 30169511.
      Citations: 1     Fields:    Translation:HumansCells
    41. Alvarado G, Ettayebi K, Atmar RL, Bombardi RG, Kose N, Estes MK, Crowe JE. Human Monoclonal Antibodies That Neutralize Pandemic GII.4 Noroviruses. Gastroenterology. 2018 12; 155(6):1898-1907. PMID: 30170116.
      Citations: 14     Fields:    Translation:HumansCells
    42. Costantini V, Morantz EK, Browne H, Ettayebi K, Zeng XL, Atmar RL, Estes MK, Vinjé J. Human Norovirus Replication in Human Intestinal Enteroids as Model to Evaluate Virus Inactivation. Emerg Infect Dis. 2018 08; 24(8):1453-1464. PMID: 30014841.
      Citations: 37     Fields:    Translation:HumansCells
    43. Hu L, Sankaran B, Laucirica DR, Patil K, Salmen W, Ferreon ACM, Tsoi PS, Lasanajak Y, Smith DF, Ramani S, Atmar RL, Estes MK, Ferreon JC, Prasad BVV. Glycan recognition in globally dominant human rotaviruses. Nat Commun. 2018 07 06; 9(1):2631. PMID: 29980685.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    44. Bányai K, Estes MK, Martella V, Parashar UD. Viral gastroenteritis. Lancet. 2018 07 14; 392(10142):175-186. PMID: 30025810.
      Citations: 25     Fields:    Translation:HumansCells
    45. Ramani S, Crawford SE, Blutt SE, Estes MK. Human organoid cultures: transformative new tools for human virus studies. Curr Opin Virol. 2018 04; 29:79-86. PMID: 29656244.
      Citations: 16     Fields:    Translation:Humans
    46. Rajan A, Vela L, Zeng XL, Yu X, Shroyer N, Blutt SE, Poole NM, Carlin LG, Nataro JP, Estes MK, Okhuysen PC, Maresso AW. Novel Segment- and Host-Specific Patterns of Enteroaggregative Escherichia coli Adherence to Human Intestinal Enteroids. mBio. 2018 02 20; 9(1). PMID: 29463660.
      Citations: 19     Fields:    Translation:HumansCells
    47. Zou WY, Blutt SE, Zeng XL, Chen MS, Lo YH, Castillo-Azofeifa D, Klein OD, Shroyer NF, Donowitz M, Estes MK. Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation. Cell Rep. 2018 01 23; 22(4):1003-1015. PMID: 29386123.
      Citations: 9     Fields:    Translation:AnimalsCells
    48. Blutt SE, Crawford SE, Ramani S, Zou WY, Estes MK. Engineered Human Gastrointestinal Cultures to Study the Microbiome and Infectious Diseases. Cell Mol Gastroenterol Hepatol. 2018 Mar; 5(3):241-251. PMID: 29675450.
      Citations: 18     Fields:    
    49. Chen Y, Zhou W, Roh T, Estes MK, Kaplan DL. In vitro enteroid-derived three-dimensional tissue model of human small intestinal epithelium with innate immune responses. PLoS One. 2017; 12(11):e0187880. PMID: 29186150.
      Citations: 21     Fields:    Translation:HumansCells
    50. Crawford SE, Ramani S, Tate JE, Parashar UD, Svensson L, Hagbom M, Franco MA, Greenberg HB, O'Ryan M, Kang G, Desselberger U, Estes MK. Rotavirus infection. Nat Rev Dis Primers. 2017 Nov 09; 3:17083. PMID: 29119972.
      Citations: 46     Fields:    Translation:Humans
    51. Poole NM, Green SI, Rajan A, Vela LE, Zeng XL, Estes MK, Maresso AW. Role for FimH in Extraintestinal Pathogenic Escherichia coli Invasion and Translocation through the Intestinal Epithelium. Infect Immun. 2017 11; 85(11). PMID: 28808163.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    52. Cortes-Penfield NW, Ramani S, Estes MK, Atmar RL. Prospects and Challenges in the Development of a Norovirus Vaccine. Clin Ther. 2017 Aug; 39(8):1537-1549. PMID: 28756066.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    53. Sharma S, Carlsson B, Czakó R, Vene S, Haglund M, Ludvigsson J, Larson G, Hammarström L, Sosnovtsev SV, Atmar RL, Green KY, Estes MK, Svensson L. Human Sera Collected between 1979 and 2010 Possess Blocking-Antibody Titers to Pandemic GII.4 Noroviruses Isolated over Three Decades. J Virol. 2017 07 15; 91(14). PMID: 28468886.
      Citations: 2     Fields:    Translation:HumansCells
    54. Laucirica DR, Triantis V, Schoemaker R, Estes MK, Ramani S. Milk Oligosaccharides Inhibit Human Rotavirus Infectivity in MA104 Cells. J Nutr. 2017 09; 147(9):1709-1714. PMID: 28637685.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    55. Shanker S, Hu L, Ramani S, Atmar RL, Estes MK, Venkataram Prasad BV. Structural features of glycan recognition among viral pathogens. Curr Opin Struct Biol. 2017 06; 44:211-218. PMID: 28591681.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    56. Blutt SE, Broughman JR, Zou W, Zeng XL, Karandikar UC, In J, Zachos NC, Kovbasnjuk O, Donowitz M, Estes MK. Gastrointestinal microphysiological systems. Exp Biol Med (Maywood). 2017 10; 242(16):1633-1642. PMID: 28534432.
      Citations: 5     Fields:    Translation:Humans
    57. Ramani S, Neill FH, Ferreira J, Treanor JJ, Frey SE, Topham DJ, Goodwin RR, Borkowski A, Baehner F, Mendelman PM, Estes MK, Atmar RL. B-Cell Responses to Intramuscular Administration of a Bivalent Virus-Like Particle Human Norovirus Vaccine. Clin Vaccine Immunol. 2017 May; 24(5). PMID: 28249841.
      Citations: 7     Fields:    Translation:HumansCellsCTClinical Trials
    58. Yu H, Hasan NM, In JG, Estes MK, Kovbasnjuk O, Zachos NC, Donowitz M. The Contributions of Human Mini-Intestines to the Study of Intestinal Physiology and Pathophysiology. Annu Rev Physiol. 2017 02 10; 79:291-312. PMID: 28192061.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    59. Hurwitz AM, Huang W, Kou B, Estes MK, Atmar RL, Palzkill T. Identification and Characterization of Single-Chain Antibodies that Specifically Bind GI Noroviruses. PLoS One. 2017; 12(1):e0170162. PMID: 28095447.
      Citations: 1     Fields:    Translation:HumansCells
    60. Saxena K, Simon LM, Zeng XL, Blutt SE, Crawford SE, Sastri NP, Karandikar UC, Ajami NJ, Zachos NC, Kovbasnjuk O, Donowitz M, Conner ME, Shaw CA, Estes MK. A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection. Proc Natl Acad Sci U S A. 2017 01 24; 114(4):E570-E579. PMID: 28069942.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    61. Hurwitz AM, Huang W, Estes MK, Atmar RL, Palzkill T. Deep sequencing of phage-displayed peptide libraries reveals sequence motif that detects norovirus. Protein Eng Des Sel. 2017 Feb; 30(2):129-139. PMID: 28035012.
      Citations: 2     Fields:    Translation:Cells
    62. Ramani S, Mamani N, Villena R, Bandyopadhyay AS, Gast C, Sato A, Laucirica D, Clemens R, Estes MK, O'Ryan ML. Rotavirus Serum IgA Immune Response in Children Receiving Rotarix Coadministered With bOPV or IPV. Pediatr Infect Dis J. 2016 10; 35(10):1137-9. PMID: 27254033.
      Citations: 10     Fields:    Translation:HumansCellsCTClinical Trials
    63. In JG, Foulke-Abel J, Estes MK, Zachos NC, Kovbasnjuk O, Donowitz M. Human mini-guts: new insights into intestinal physiology and host-pathogen interactions. Nat Rev Gastroenterol Hepatol. 2016 Nov; 13(11):633-642. PMID: 27677718.
      Citations: 36     Fields:    Translation:Humans
    64. Shanker S, Czakó R, Sapparapu G, Alvarado G, Viskovska M, Sankaran B, Atmar RL, Crowe JE, Estes MK, Prasad BV. Structural basis for norovirus neutralization by an HBGA blocking human IgA antibody. Proc Natl Acad Sci U S A. 2016 10 04; 113(40):E5830-E5837. PMID: 27647885.
      Citations: 12     Fields:    Translation:HumansCells
    65. Qu L, Murakami K, Broughman JR, Lay MK, Guix S, Tenge VR, Atmar RL, Estes MK. Replication of Human Norovirus RNA in Mammalian Cells Reveals Lack of Interferon Response. J Virol. 2016 10 01; 90(19):8906-23. PMID: 27466422.
      Citations: 13     Fields:    Translation:HumansCells
    66. Ettayebi K, Crawford SE, Murakami K, Broughman JR, Karandikar U, Tenge VR, Neill FH, Blutt SE, Zeng XL, Qu L, Kou B, Opekun AR, Burrin D, Graham DY, Ramani S, Atmar RL, Estes MK. Replication of human noroviruses in stem cell-derived human enteroids. Science. 2016 09 23; 353(6306):1387-1393. PMID: 27562956.
      Citations: 290     Fields:    Translation:HumansCells
    67. Hesse S, Neill FH, Estes MK, Shanker S, Prasad BV, Ferreira J, Atmar RL. Correction for Hesse et al., Serological Responses to a Norovirus Nonstructural Fusion Protein after Vaccination and Infection. Clin Vaccine Immunol. 2016 08; 23(8):735. PMID: 27495982.
      Citations:    Fields:    
    68. Lloyd RE, Estes MK. Editorial overview: Viruses and cell metabolism. Curr Opin Virol. 2016 08; 19:vii-viii. PMID: 27619793.
      Citations: 1     Fields:    Translation:HumansCells
    69. Karandikar UC, Crawford SE, Ajami NJ, Murakami K, Kou B, Ettayebi K, Papanicolaou GA, Jongwutiwes U, Perales MA, Shia J, Mercer D, Finegold MJ, Vinjé J, Atmar RL, Estes MK. Detection of human norovirus in intestinal biopsies from immunocompromised transplant patients. J Gen Virol. 2016 09; 97(9):2291-2300. PMID: 27412790.
      Citations: 25     Fields:    Translation:HumansCells
    70. Sapparapu G, Czakó R, Alvarado G, Shanker S, Prasad BV, Atmar RL, Estes MK, Crowe JE. Frequent Use of the IgA Isotype in Human B Cells Encoding Potent Norovirus-Specific Monoclonal Antibodies That Block HBGA Binding. PLoS Pathog. 2016 06; 12(6):e1005719. PMID: 27355511.
      Citations: 8     Fields:    Translation:HumansCells
    71. Mills M, Estes MK. Physiologically relevant human tissue models for infectious diseases. Drug Discov Today. 2016 09; 21(9):1540-1552. PMID: 27352632.
      Citations: 10     Fields:    Translation:HumansAnimals
    72. Prasad BV, Shanker S, Muhaxhiri Z, Deng L, Choi JM, Estes MK, Song Y, Palzkill T, Atmar RL. Antiviral targets of human noroviruses. Curr Opin Virol. 2016 06; 18:117-25. PMID: 27318434.
      Citations: 13     Fields:    Translation:HumansCells
    73. Menon VK, George S, Sarkar R, Giri S, Samuel P, Vivek R, Saravanabavan A, Liakath FB, Ramani S, Iturriza-Gomara M, Gray JJ, Brown DW, Estes MK, Kang G. Norovirus Gastroenteritis in a Birth Cohort in Southern India. PLoS One. 2016; 11(6):e0157007. PMID: 27284939.
      Citations: 10     Fields:    Translation:HumansCells
    74. Ramani S, Estes MK, Atmar RL. Correlates of Protection against Norovirus Infection and Disease-Where Are We Now, Where Do We Go? PLoS Pathog. 2016 04; 12(4):e1005334. PMID: 27115358.
      Citations: 16     Fields:    Translation:HumansCells
    75. Ramani S, Hu L, Venkataram Prasad BV, Estes MK. Diversity in Rotavirus-Host Glycan Interactions: A "Sweet" Spectrum. Cell Mol Gastroenterol Hepatol. 2016 May; 2(3):263-273. PMID: 28090561.
      Citations: 15     Fields:    
    76. In J, Foulke-Abel J, Zachos NC, Hansen AM, Kaper JB, Bernstein HD, Halushka M, Blutt S, Estes MK, Donowitz M, Kovbasnjuk O. Enterohemorrhagic Escherichia coli reduce mucus and intermicrovillar bridges in human stem cell-derived colonoids. Cell Mol Gastroenterol Hepatol. 2016 Jan 01; 2(1):48-62.e3. PMID: 26855967.
      Citations: 62     Fields:    
    77. Zachos NC, Kovbasnjuk O, Foulke-Abel J, In J, Blutt SE, de Jonge HR, Estes MK, Donowitz M. Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology. J Biol Chem. 2016 Feb 19; 291(8):3759-66. PMID: 26677228.
      Citations: 71     Fields:    Translation:HumansCells
    78. Hesse S, Neill FH, Estes MK, Shanker S, Prasad BV, Ferreira J, Atmar RL. Serological Responses to a Norovirus Nonstructural Fusion Protein after Vaccination and Infection. Clin Vaccine Immunol. 2016 02; 23(2):181-3. PMID: 26656120.
      Citations: 1     Fields:    Translation:HumansCells
    79. Foulke-Abel J, In J, Yin J, Zachos NC, Kovbasnjuk O, Estes MK, de Jonge H, Donowitz M. Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology. Gastroenterology. 2016 Mar; 150(3):638-649.e8. PMID: 26677983.
      Citations: 57     Fields:    Translation:Humans
    80. Hyser JM, Estes MK. Pathophysiological Consequences of Calcium-Conducting Viroporins. Annu Rev Virol. 2015 Nov; 2(1):473-96. PMID: 26958925.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    81. Kou B, Huang W, Neill FH, Palzkill T, Estes MK, Atmar RL. Norovirus Antigen Detection with a Combination of Monoclonal and Single-Chain Antibodies. J Clin Microbiol. 2015 Dec; 53(12):3916-8. PMID: 26447115.
      Citations: 5     Fields:    Translation:HumansCells
    82. Saxena K, Blutt SE, Ettayebi K, Zeng XL, Broughman JR, Crawford SE, Karandikar UC, Sastri NP, Conner ME, Opekun AR, Graham DY, Qureshi W, Sherman V, Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Donowitz M, Estes MK. Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and Pathophysiology. J Virol. 2016 01 01; 90(1):43-56. PMID: 26446608.
      Citations: 103     Fields:    Translation:HumansCells
    83. Hu L, Ramani S, Czako R, Sankaran B, Yu Y, Smith DF, Cummings RD, Estes MK, Venkataram Prasad BV. Structural basis of glycan specificity in neonate-specific bovine-human reassortant rotavirus. Nat Commun. 2015 Sep 30; 6:8346. PMID: 26420502.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    84. Atmar RL, Bernstein DI, Lyon GM, Treanor JJ, Al-Ibrahim MS, Graham DY, Vinjé J, Jiang X, Gregoricus N, Frenck RW, Moe CL, Chen WH, Ferreira J, Barrett J, Opekun AR, Estes MK, Borkowski A, Baehner F, Goodwin R, Edmonds A, Mendelman PM. Serological Correlates of Protection against a GII.4 Norovirus. Clin Vaccine Immunol. 2015 Aug; 22(8):923-9. PMID: 26041041.
      Citations: 32     Fields:    Translation:HumansCellsCTClinical Trials
    85. Henning SJ, Estes MK. Women in Science: Hints for Success. Gastroenterology. 2015 Jul; 149(1):10-3. PMID: 26021234.
      Citations:    Fields:    Translation:Humans
    86. Hagström AE, Garvey G, Paterson AS, Dhamane S, Adhikari M, Estes MK, Strych U, Kourentzi K, Atmar RL, Willson RC. Sensitive detection of norovirus using phage nanoparticle reporters in lateral-flow assay. PLoS One. 2015; 10(5):e0126571. PMID: 25978622.
      Citations: 11     Fields:    Translation:HumansCells
    87. Ramani S, Neill FH, Opekun AR, Gilger MA, Graham DY, Estes MK, Atmar RL. Mucosal and Cellular Immune Responses to Norwalk Virus. J Infect Dis. 2015 Aug 01; 212(3):397-405. PMID: 25635121.
      Citations: 37     Fields:    Translation:HumansCells
    88. Czakó R, Atmar RL, Opekun AR, Gilger MA, Graham DY, Estes MK. Experimental human infection with Norwalk virus elicits a surrogate neutralizing antibody response with cross-genogroup activity. Clin Vaccine Immunol. 2015 Feb; 22(2):221-8. PMID: 25540269.
      Citations: 11     Fields:    Translation:HumansCells
    89. Crawford SE, Ajami N, Parker TD, Kitamoto N, Natori K, Takeda N, Tanaka T, Kou B, Atmar RL, Estes MK. Mapping broadly reactive norovirus genogroup I and II monoclonal antibodies. Clin Vaccine Immunol. 2015 Feb; 22(2):168-77. PMID: 25428246.
      Citations: 7     Fields:    Translation:AnimalsCells
    90. Kou B, Crawford SE, Ajami NJ, Czakó R, Neill FH, Tanaka TN, Kitamoto N, Palzkill TG, Estes MK, Atmar RL. Characterization of cross-reactive norovirus-specific monoclonal antibodies. Clin Vaccine Immunol. 2015 Feb; 22(2):160-7. PMID: 25428247.
      Citations: 12     Fields:    Translation:HumansCells
    91. Zhang B, Chassaing B, Shi Z, Uchiyama R, Zhang Z, Denning TL, Crawford SE, Pruijssers AJ, Iskarpatyoti JA, Estes MK, Dermody TS, Ouyang W, Williams IR, Vijay-Kumar M, Gewirtz AT. Viral infection. Prevention and cure of rotavirus infection via TLR5/NLRC4-mediated production of IL-22 and IL-18. Science. 2014 Nov 14; 346(6211):861-5. PMID: 25395539.
      Citations: 69     Fields:    Translation:Animals
    92. Sastri NP, Viskovska M, Hyser JM, Tanner MR, Horton LB, Sankaran B, Prasad BV, Estes MK. Structural plasticity of the coiled-coil domain of rotavirus NSP4. J Virol. 2014 Dec; 88(23):13602-12. PMID: 25231315.
      Citations: 3     Fields:    Translation:Cells
    93. Bernstein DI, Atmar RL, Lyon GM, Treanor JJ, Chen WH, Jiang X, Vinjé J, Gregoricus N, Frenck RW, Moe CL, Al-Ibrahim MS, Barrett J, Ferreira J, Estes MK, Graham DY, Goodwin R, Borkowski A, Clemens R, Mendelman PM. Norovirus vaccine against experimental human GII.4 virus illness: a challenge study in healthy adults. J Infect Dis. 2015 Mar 15; 211(6):870-8. PMID: 25210140.
      Citations: 83     Fields:    Translation:HumansCellsPHPublic Health
    94. Katayama K, Murakami K, Sharp TM, Guix S, Oka T, Takai-Todaka R, Nakanishi A, Crawford SE, Atmar RL, Estes MK. Plasmid-based human norovirus reverse genetics system produces reporter-tagged progeny virus containing infectious genomic RNA. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):E4043-52. PMID: 25192933.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    95. Viskovska M, Anish R, Hu L, Chow DC, Hurwitz AM, Brown NG, Palzkill T, Estes MK, Prasad BV. Probing the sites of interactions of rotaviral proteins involved in replication. J Virol. 2014 Nov; 88(21):12866-81. PMID: 25165107.
      Citations: 7     Fields:    Translation:Cells
    96. Venkataram Prasad BV, Shanker S, Hu L, Choi JM, Crawford SE, Ramani S, Czako R, Atmar RL, Estes MK. Structural basis of glycan interaction in gastroenteric viral pathogens. Curr Opin Virol. 2014 Aug; 7:119-27. PMID: 25073118.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    97. Yu Y, Lasanajak Y, Song X, Hu L, Ramani S, Mickum ML, Ashline DJ, Prasad BV, Estes MK, Reinhold VN, Cummings RD, Smith DF. Human milk contains novel glycans that are potential decoy receptors for neonatal rotaviruses. Mol Cell Proteomics. 2014 Nov; 13(11):2944-60. PMID: 25048705.
      Citations: 42     Fields:    Translation:HumansCells
    98. Ashline DJ, Yu Y, Lasanajak Y, Song X, Hu L, Ramani S, Prasad V, Estes MK, Cummings RD, Smith DF, Reinhold VN. Structural characterization by multistage mass spectrometry (MSn) of human milk glycans recognized by human rotaviruses. Mol Cell Proteomics. 2014 Nov; 13(11):2961-74. PMID: 25048706.
      Citations: 20     Fields:    Translation:HumansCells
    99. Atmar RL, Opekun AR, Estes MK, Graham DY. Reply to Kirby et al. J Infect Dis. 2015 Jan 01; 211(1):167. PMID: 25015947.
      Citations:    Fields:    Translation:HumansCells
    100. Qu L, Vongpunsawad S, Atmar RL, Prasad BV, Estes MK. Development of a Gaussia luciferase-based human norovirus protease reporter system: cell type-specific profile of Norwalk virus protease precursors and evaluation of inhibitors. J Virol. 2014 Sep; 88(18):10312-26. PMID: 25008934.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    101. Huang W, Samanta M, Crawford SE, Estes MK, Neill FH, Atmar RL, Palzkill T. Identification of human single-chain antibodies with broad reactivity for noroviruses. Protein Eng Des Sel. 2014 Oct; 27(10):339-49. PMID: 24946948.
      Citations: 12     Fields:    Translation:HumansCells
    102. Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Ettayebi K, Blutt SE, Hyser JM, Zeng XL, Crawford SE, Broughman JR, Estes MK, Donowitz M. Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract. Exp Biol Med (Maywood). 2014 Sep; 239(9):1124-34. PMID: 24719375.
      Citations: 67     Fields:    Translation:HumansCells
    103. Shanker S, Czako R, Sankaran B, Atmar RL, Estes MK, Prasad BV. Structural analysis of determinants of histo-blood group antigen binding specificity in genogroup I noroviruses. J Virol. 2014 Jun; 88(11):6168-80. PMID: 24648450.
      Citations: 18     Fields:    Translation:HumansCells
    104. Ramani S, Atmar RL, Estes MK. Epidemiology of human noroviruses and updates on vaccine development. Curr Opin Gastroenterol. 2014 Jan; 30(1):25-33. PMID: 24232370.
      Citations: 68     Fields:    Translation:HumansCells
    105. Ajami NJ, Kavanagh OV, Ramani S, Crawford SE, Atmar RL, Jiang ZD, Okhuysen PC, Estes MK, DuPont HL. Seroepidemiology of norovirus-associated travelers' diarrhea. J Travel Med. 2014 Jan-Feb; 21(1):6-11. PMID: 24383649.
      Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
    106. Kovbasnjuk O, Zachos NC, In J, Foulke-Abel J, Ettayebi K, Hyser JM, Broughman JR, Zeng XL, Middendorp S, de Jonge HR, Estes MK, Donowitz M. Human enteroids: preclinical models of non-inflammatory diarrhea. Stem Cell Res Ther. 2013; 4 Suppl 1:S3. PMID: 24564938.
      Citations: 24     Fields:    Translation:HumansCells
    107. Atmar RL, Opekun AR, Gilger MA, Estes MK, Crawford SE, Neill FH, Ramani S, Hill H, Ferreira J, Graham DY. Determination of the 50% human infectious dose for Norwalk virus. J Infect Dis. 2014 Apr 01; 209(7):1016-22. PMID: 24253285.
      Citations: 80     Fields:    Translation:HumansCells
    108. Criglar JM, Hu L, Crawford SE, Hyser JM, Broughman JR, Prasad BV, Estes MK. A novel form of rotavirus NSP2 and phosphorylation-dependent NSP2-NSP5 interactions are associated with viroplasm assembly. J Virol. 2014 Jan; 88(2):786-98. PMID: 24198401.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    109. Hyser JM, Utama B, Crawford SE, Broughman JR, Estes MK. Activation of the endoplasmic reticulum calcium sensor STIM1 and store-operated calcium entry by rotavirus requires NSP4 viroporin activity. J Virol. 2013 Dec; 87(24):13579-88. PMID: 24109210.
      Citations: 17     Fields:    Translation:HumansCells
    110. Deng L, Muhaxhiri Z, Estes MK, Palzkill T, Prasad BV, Song Y. Synthesis, Activity and Structure-Activity Relationship of Noroviral Protease Inhibitors. Medchemcomm. 2013 Oct; 4(10). PMID: 24244836.
      Citations:    
    111. Hertel PM, Crawford SE, Bessard BC, Estes MK. Prevention of cholestasis in the murine rotavirus-induced biliary atresia model using passive immunization and nonreplicating virus-like particles. Vaccine. 2013 Nov 19; 31(48):5778-84. PMID: 23887039.
      Citations: 1     Fields:    Translation:Animals
    112. Menon VK, George S, Shanti AA, Saravanabavan A, Samuel P, Ramani S, Estes MK, Kang G. Exposure to human and bovine noroviruses in a birth cohort in southern India from 2002 to 2006. J Clin Microbiol. 2013 Jul; 51(7):2391-5. PMID: 23616452.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    113. Ramani S, Cortes-Penfield NW, Hu L, Crawford SE, Czako R, Smith DF, Kang G, Ramig RF, Le Pendu J, Prasad BV, Estes MK. The VP8* domain of neonatal rotavirus strain G10P[11] binds to type II precursor glycans. J Virol. 2013 Jul; 87(13):7255-64. PMID: 23616650.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    114. Rogers JD, Ajami NJ, Fryszczyn BG, Estes MK, Atmar RL, Palzkill T. Identification and characterization of a peptide affinity reagent for detection of noroviruses in clinical samples. J Clin Microbiol. 2013 Jun; 51(6):1803-8. PMID: 23554202.
      Citations: 8     Fields:    Translation:HumansCells
    115. Herbst-Kralovetz MM, Radtke AL, Lay MK, Hjelm BE, Bolick AN, Sarker SS, Atmar RL, Kingsley DH, Arntzen CJ, Estes MK, Nickerson CA. Lack of norovirus replication and histo-blood group antigen expression in 3-dimensional intestinal epithelial cells. Emerg Infect Dis. 2013 Mar; 19(3):431-8. PMID: 23622517.
      Citations: 35     Fields:    Translation:HumansCells
    116. Crawford SE, Estes MK. Viroporin-mediated calcium-activated autophagy. Autophagy. 2013 May; 9(5):797-8. PMID: 23442576.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    117. Vongpunsawad S, Venkataram Prasad BV, Estes MK. Norwalk Virus Minor Capsid Protein VP2 Associates within the VP1 Shell Domain. J Virol. 2013 May; 87(9):4818-25. PMID: 23408637.
      Citations: 41     Fields:    Translation:HumansCells
    118. Muhaxhiri Z, Deng L, Shanker S, Sankaran B, Estes MK, Palzkill T, Song Y, Prasad BV. Structural basis of substrate specificity and protease inhibition in Norwalk virus. J Virol. 2013 Apr; 87(8):4281-92. PMID: 23365454.
      Citations: 25     Fields:    Translation:Cells
    119. Crawford SE, Hyser JM, Utama B, Estes MK. Autophagy hijacked through viroporin-activated calcium/calmodulin-dependent kinase kinase-ß signaling is required for rotavirus replication. Proc Natl Acad Sci U S A. 2012 Dec 11; 109(50):E3405-13. PMID: 23184977.
      Citations: 57     Fields:    Translation:AnimalsCells
    120. Kavanagh O, Zeng XL, Ramani S, Mukhopadhya I, Crawford SE, Kang G, Estes MK. A time-resolved immunoassay to measure serum antibodies to the rotavirus VP6 capsid protein. J Virol Methods. 2013 Apr; 189(1):228-31. PMID: 23183143.
      Citations: 4     Fields:    Translation:HumansCells
    121. Ajami NJ, Barry MA, Carrillo B, Muhaxhiri Z, Neill FH, Prasad BV, Opekun AR, Gilger MA, Graham DY, Atmar RL, Estes MK. Antibody responses to norovirus genogroup GI.1 and GII.4 proteases in volunteers administered Norwalk virus. Clin Vaccine Immunol. 2012 Dec; 19(12):1980-3. PMID: 23035177.
      Citations: 9     Fields:    Translation:HumansCells
    122. Sharp TM, Crawford SE, Ajami NJ, Neill FH, Atmar RL, Katayama K, Utama B, Estes MK. Secretory pathway antagonism by calicivirus homologues of Norwalk virus nonstructural protein p22 is restricted to noroviruses. Virol J. 2012 Sep 03; 9:181. PMID: 22943503.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    123. Atmar RL, Estes MK. Norovirus vaccine development: next steps. Expert Rev Vaccines. 2012 Sep; 11(9):1023-5. PMID: 23151158.
      Citations: 25     Fields:    Translation:HumansCells
    124. Koo HL, Neill FH, Estes MK, Munoz FM, Cameron A, DuPont HL, Atmar RL. Noroviruses: The Most Common Pediatric Viral Enteric Pathogen at a Large University Hospital After Introduction of Rotavirus Vaccination. J Pediatric Infect Dis Soc. 2013 Mar; 2(1):57-60. PMID: 23687584.
      Citations: 56     Fields:    
    125. Hu L, Chow DC, Patton JT, Palzkill T, Estes MK, Prasad BV. Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5' GG Sequence for RTPase Activity. J Virol. 2012 Oct; 86(19):10547-57. PMID: 22811529.
      Citations: 11     Fields:    Translation:Cells
    126. Hu L, Crawford SE, Hyser JM, Estes MK, Prasad BV. Rotavirus non-structural proteins: structure and function. Curr Opin Virol. 2012 Aug; 2(4):380-8. PMID: 22789743.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    127. Finkbeiner SR, Zeng XL, Utama B, Atmar RL, Shroyer NF, Estes MK. Stem cell-derived human intestinal organoids as an infection model for rotaviruses. mBio. 2012; 3(4):e00159-12. PMID: 22761392.
      Citations: 76     Fields:    Translation:HumansCells
    128. Estes MK, Desselberger U. Rotaviruses: cause of vaccine-preventable disease yet many fundamental questions remain to be explored. Curr Opin Virol. 2012 Aug; 2(4):369-72. PMID: 22762866.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    129. Hu L, Crawford SE, Czako R, Cortes-Penfield NW, Smith DF, Le Pendu J, Estes MK, Prasad BV. Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen. Nature. 2012 Apr 15; 485(7397):256-9. PMID: 22504179.
      Citations: 100     Fields:    Translation:HumansAnimalsCells
    130. Hyser JM, Utama B, Crawford SE, Estes MK. Genetic divergence of rotavirus nonstructural protein 4 results in distinct serogroup-specific viroporin activity and intracellular punctate structure morphologies. J Virol. 2012 May; 86(9):4921-34. PMID: 22357281.
      Citations: 11     Fields:    Translation:AnimalsCells
    131. Hertel PM, Estes MK. Rotavirus and biliary atresia: can causation be proven? Curr Opin Gastroenterol. 2012 Jan; 28(1):10-7. PMID: 22123643.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    132. Czakó R, Atmar RL, Opekun AR, Gilger MA, Graham DY, Estes MK. Serum hemagglutination inhibition activity correlates with protection from gastroenteritis in persons infected with Norwalk virus. Clin Vaccine Immunol. 2012 Feb; 19(2):284-7. PMID: 22190401.
      Citations: 25     Fields:    Translation:HumansCells
    133. Atmar RL, Bernstein DI, Harro CD, Al-Ibrahim MS, Chen WH, Ferreira J, Estes MK, Graham DY, Opekun AR, Richardson C, Mendelman PM. Norovirus vaccine against experimental human Norwalk Virus illness. N Engl J Med. 2011 Dec 08; 365(23):2178-87. PMID: 22150036.
      Citations: 168     Fields:    Translation:HumansCells
    134. Baclayon M, Shoemaker GK, Uetrecht C, Crawford SE, Estes MK, Prasad BV, Heck AJ, Wuite GJ, Roos WH. Prestress strengthens the shell of Norwalk virus nanoparticles. . 2011 Nov 09; 11(11):4865-9. PMID: 21967663.
      Citations:    
    135. Gladstone BP, Ramani S, Mukhopadhya I, Muliyil J, Sarkar R, Rehman AM, Jaffar S, Gomara MI, Gray JJ, Brown DW, Desselberger U, Crawford SE, John J, Babji S, Estes MK, Kang G. Protective effect of natural rotavirus infection in an Indian birth cohort. N Engl J Med. 2011 Jul 28; 365(4):337-46. PMID: 21793745.
      Citations: 56     Fields:    Translation:HumansCells
    136. Hertel PM, Crawford SE, Finegold MJ, Estes MK. Osteopontin upregulation in rotavirus-induced murine biliary atresia requires replicating virus but is not necessary for development of biliary atresia. Virology. 2011 Sep 01; 417(2):281-92. PMID: 21742364.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    137. Shanker S, Choi JM, Sankaran B, Atmar RL, Estes MK, Prasad BV. Structural analysis of histo-blood group antigen binding specificity in a norovirus GII.4 epidemic variant: implications for epochal evolution. J Virol. 2011 Sep; 85(17):8635-45. PMID: 21715503.
      Citations: 71     Fields:    Translation:HumansCells
    138. Pan S, Wang S, Utama B, Huang L, Blok N, Estes MK, Moremen KW, Sifers RN. Golgi localization of ERManI defines spatial separation of the mammalian glycoprotein quality control system. Mol Biol Cell. 2011 Aug 15; 22(16):2810-22. PMID: 21697506.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    139. Matthijnssens J, Ciarlet M, McDonald SM, Attoui H, Bányai K, Brister JR, Buesa J, Esona MD, Estes MK, Gentsch JR, Iturriza-Gómara M, Johne R, Kirkwood CD, Martella V, Mertens PP, Nakagomi O, Parreño V, Rahman M, Ruggeri FM, Saif LJ, Santos N, Steyer A, Taniguchi K, Patton JT, Desselberger U, Van Ranst M. Uniformity of rotavirus strain nomenclature proposed by the Rotavirus Classification Working Group (RCWG). Arch Virol. 2011 Aug; 156(8):1397-413. PMID: 21597953.
      Citations: 214     Fields:    Translation:HumansAnimalsCells
    140. Kavanagh O, Estes MK, Reeck A, Raju RM, Opekun AR, Gilger MA, Graham DY, Atmar RL. Serological responses to experimental Norwalk virus infection measured using a quantitative duplex time-resolved fluorescence immunoassay. Clin Vaccine Immunol. 2011 Jul; 18(7):1187-90. PMID: 21593238.
      Citations: 13     Fields:    Translation:HumansCells
    141. Criglar J, Greenberg HB, Estes MK, Ramig RF. Reconciliation of rotavirus temperature-sensitive mutant collections and assignment of reassortment groups D, J, and K to genome segments. J Virol. 2011 May; 85(10):5048-60. PMID: 21367894.
      Citations: 1     Fields:    Translation:Cells
    142. da Silva AK, Kavanagh OV, Estes MK, Elimelech M. Adsorption and aggregation properties of norovirus GI and GII virus-like particles demonstrate differing responses to solution chemistry. Environ Sci Technol. 2011 Jan 15; 45(2):520-6. PMID: 21121659.
      Citations: 17     Fields:    Translation:Cells
    143. Hyser JM, Collinson-Pautz MR, Utama B, Estes MK. Rotavirus disrupts calcium homeostasis by NSP4 viroporin activity. mBio. 2010 Nov 30; 1(5). PMID: 21151776.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    144. Sharp TM, Guix S, Katayama K, Crawford SE, Estes MK. Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. PLoS One. 2010 Oct 18; 5(10):e13130. PMID: 20976190.
      Citations: 29     Fields:    Translation:Cells
    145. Reeck A, Kavanagh O, Estes MK, Opekun AR, Gilger MA, Graham DY, Atmar RL. Serological correlate of protection against norovirus-induced gastroenteritis. J Infect Dis. 2010 Oct 15; 202(8):1212-8. PMID: 20815703.
      Citations: 106     Fields:    Translation:HumansCellsCTClinical Trials
    146. Sharp TM, Estes MK. An inside job: subversion of the host secretory pathway by intestinal pathogens. Curr Opin Infect Dis. 2010 Oct; 23(5):464-9. PMID: 20717028.
      Citations: 3     Fields:    Translation:HumansCells
    147. Lay MK, Atmar RL, Guix S, Bharadwaj U, He H, Neill FH, Sastry KJ, Yao Q, Estes MK. Norwalk virus does not replicate in human macrophages or dendritic cells derived from the peripheral blood of susceptible humans. Virology. 2010 Oct 10; 406(1):1-11. PMID: 20667573.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    148. Deal EM, Jaimes MC, Crawford SE, Estes MK, Greenberg HB. Rotavirus structural proteins and dsRNA are required for the human primary plasmacytoid dendritic cell IFNalpha response. PLoS Pathog. 2010 Jun 03; 6(6):e1000931. PMID: 20532161.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    149. Shoemaker GK, van Duijn E, Crawford SE, Uetrecht C, Baclayon M, Roos WH, Wuite GJ, Estes MK, Prasad BV, Heck AJ. Norwalk virus assembly and stability monitored by mass spectrometry. Mol Cell Proteomics. 2010 Aug; 9(8):1742-51. PMID: 20418222.
      Citations: 38     Fields:    Translation:Cells
    150. Kavanagh OV, Ajami NJ, Cheng E, Ciarlet M, Guerrero RA, Zeng CQ, Crawford SE, Estes MK. Rotavirus enterotoxin NSP4 has mucosal adjuvant properties. Vaccine. 2010 Apr 19; 28(18):3106-11. PMID: 20197138.
      Citations: 4     Fields:    Translation:Animals
    151. Patel NC, Hertel PM, Estes MK, de la Morena M, Petru AM, Noroski LM, Revell PA, Hanson IC, Paul ME, Rosenblatt HM, Abramson SL. Vaccine-acquired rotavirus in infants with severe combined immunodeficiency. N Engl J Med. 2010 Jan 28; 362(4):314-9. PMID: 20107217.
      Citations: 53     Fields:    Translation:HumansCells
    152. Gladstone BP, Das AR, Rehman AM, Jaffar S, Estes MK, Muliyil J, Kang G, Bose A. Burden of illness in the first 3 years of life in an Indian slum. J Trop Pediatr. 2010 Aug; 56(4):221-6. PMID: 20028725.
      Citations: 22     Fields:    Translation:Humans
    153. Glass RI, Parashar UD, Estes MK. Norovirus gastroenteritis. N Engl J Med. 2009 Oct 29; 361(18):1776-85. PMID: 19864676.
      Citations: 315     Fields:    Translation:HumansCells
    154. Greenberg HB, Estes MK. Rotaviruses: from pathogenesis to vaccination. Gastroenterology. 2009 May; 136(6):1939-51. PMID: 19457420.
      Citations: 109     Fields:    Translation:HumansCellsPHPublic Health
    155. Hyser JM, Estes MK. Rotavirus vaccines and pathogenesis: 2008. Curr Opin Gastroenterol. 2009 Jan; 25(1):36-43. PMID: 19114772.
      Citations: 7     Fields:    Translation:HumansCellsPHPublic Health
    156. Li Z, Baker ML, Jiang W, Estes MK, Prasad BV. Rotavirus architecture at subnanometer resolution. J Virol. 2009 Feb; 83(4):1754-66. PMID: 19036817.
      Citations: 44     Fields:    Translation:Cells
    157. Atmar RL, Opekun AR, Gilger MA, Estes MK, Crawford SE, Neill FH, Graham DY. Norwalk virus shedding after experimental human infection. Emerg Infect Dis. 2008 Oct; 14(10):1553-7. PMID: 18826818.
      Citations: 186     Fields:    Translation:HumansCells
    158. Matthijnssens J, Ciarlet M, Rahman M, Attoui H, Bányai K, Estes MK, Gentsch JR, Iturriza-Gómara M, Kirkwood CD, Martella V, Mertens PP, Nakagomi O, Patton JT, Ruggeri FM, Saif LJ, Santos N, Steyer A, Taniguchi K, Desselberger U, Van Ranst M. Recommendations for the classification of group A rotaviruses using all 11 genomic RNA segments. Arch Virol. 2008; 153(8):1621-9. PMID: 18604469.
      Citations: 125     Fields:    Translation:Cells
    159. Choi JM, Hutson AM, Estes MK, Prasad BV. Atomic resolution structural characterization of recognition of histo-blood group antigens by Norwalk virus. Proc Natl Acad Sci U S A. 2008 Jul 08; 105(27):9175-80. PMID: 18599458.
      Citations: 105     Fields:    Translation:HumansCells
    160. Seo NS, Zeng CQ, Hyser JM, Utama B, Crawford SE, Kim KJ, Höök M, Estes MK. Integrins alpha1beta1 and alpha2beta1 are receptors for the rotavirus enterotoxin. Proc Natl Acad Sci U S A. 2008 Jul 01; 105(26):8811-8. PMID: 18587047.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    161. Blutt SE, Warfield KL, Estes MK, Conner ME. Differential requirements for T cells in viruslike particle- and rotavirus-induced protective immunity. J Virol. 2008 Mar; 82(6):3135-8. PMID: 18184712.
      Citations: 6     Fields:    Translation:AnimalsCells
    162. Hyser JM, Zeng CQ, Beharry Z, Palzkill T, Estes MK. Epitope mapping and use of epitope-specific antisera to characterize the VP5* binding site in rotavirus SA11 NSP4. Virology. 2008 Mar 30; 373(1):211-28. PMID: 18164740.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    163. Guix S, Asanaka M, Katayama K, Crawford SE, Neill FH, Atmar RL, Estes MK. Norwalk virus RNA is infectious in mammalian cells. J Virol. 2007 Nov; 81(22):12238-48. PMID: 17855551.
      Citations: 62     Fields:    Translation:HumansCells
    164. Beau I, Cotte-Laffitte J, Géniteau-Legendre M, Estes MK, Servin AL. An NSP4-dependant mechanism by which rotavirus impairs lactase enzymatic activity in brush border of human enterocyte-like Caco-2 cells. Cell Microbiol. 2007 Sep; 9(9):2254-66. PMID: 17506819.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    165. Banerjee I, Gladstone BP, Le Fevre AM, Ramani S, Iturriza-Gomara M, Gray JJ, Brown DW, Estes MK, Muliyil JP, Jaffar S, Kang G. Neonatal infection with G10P[11] rotavirus did not confer protection against subsequent rotavirus infection in a community cohort in Vellore, South India. J Infect Dis. 2007 Mar 01; 195(5):625-32. PMID: 17262703.
      Citations: 16     Fields:    Translation:HumansCells
    166. Berkova Z, Crawford SE, Blutt SE, Morris AP, Estes MK. Expression of rotavirus NSP4 alters the actin network organization through the actin remodeling protein cofilin. J Virol. 2007 Apr; 81(7):3545-53. PMID: 17229686.
      Citations: 16     Fields:    Translation:HumansCells
    167. Ramani S, Banerjee I, Gladstone BP, Sarkar R, Selvapandian D, Le Fevre AM, Jaffar S, Iturriza-Gomara M, Gray JJ, Estes MK, Brown DW, Kang G. Geographic information systems and genotyping in identification of rotavirus G12 infections in residents of an urban slum with subsequent detection in hospitalized children: emergence of G12 genotype in South India. J Clin Microbiol. 2007 Feb; 45(2):432-7. PMID: 17135437.
      Citations: 13     Fields:    Translation:HumansCellsPHPublic Health
    168. Larsson MM, Rydell GE, Grahn A, Rodriguez-Diaz J, Akerlind B, Hutson AM, Estes MK, Larson G, Svensson L. Antibody prevalence and titer to norovirus (genogroup II) correlate with secretor (FUT2) but not with ABO phenotype or Lewis (FUT3) genotype. J Infect Dis. 2006 Nov 15; 194(10):1422-7. PMID: 17054072.
      Citations: 37     Fields:    Translation:HumansCells
    169. Estes MK, Prasad BV, Atmar RL. Noroviruses everywhere: has something changed? Curr Opin Infect Dis. 2006 Oct; 19(5):467-74. PMID: 16940871.
      Citations: 75     Fields:    Translation:HumansCells
    170. Jiang X, Jayaram H, Kumar M, Ludtke SJ, Estes MK, Prasad BV. Cryoelectron microscopy structures of rotavirus NSP2-NSP5 and NSP2-RNA complexes: implications for genome replication. J Virol. 2006 Nov; 80(21):10829-35. PMID: 16928740.
      Citations: 30     Fields:    Translation:Cells
    171. Zhang X, Buehner NA, Hutson AM, Estes MK, Mason HS. Tomato is a highly effective vehicle for expression and oral immunization with Norwalk virus capsid protein. Plant Biotechnol J. 2006 Jul; 4(4):419-32. PMID: 17177807.
      Citations: 33     Fields:    Translation:AnimalsCellsPHPublic Health
    172. Banerjee I, Ramani S, Primrose B, Moses P, Iturriza-Gomara M, Gray JJ, Jaffar S, Monica B, Muliyil JP, Brown DW, Estes MK, Kang G. Comparative study of the epidemiology of rotavirus in children from a community-based birth cohort and a hospital in South India. J Clin Microbiol. 2006 Jul; 44(7):2468-74. PMID: 16825366.
      Citations: 36     Fields:    Translation:HumansCells
    173. Le Guyader F, Loisy F, Atmar RL, Hutson AM, Estes MK, Ruvoën-Clouet N, Pommepuy M, Le Pendu J. Norwalk virus-specific binding to oyster digestive tissues. Emerg Infect Dis. 2006 Jun; 12(6):931-6. PMID: 16707048.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    174. Atmar RL, Estes MK. The epidemiologic and clinical importance of norovirus infection. Gastroenterol Clin North Am. 2006 Jun; 35(2):275-90, viii. PMID: 16880066.
      Citations: 77     Fields:    Translation:HumansCells
    175. Chen R, Neill JD, Estes MK, Prasad BV. X-ray structure of a native calicivirus: structural insights into antigenic diversity and host specificity. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):8048-53. PMID: 16702551.
      Citations: 68     Fields:    Translation:Cells
    176. Crawford SE, Patel DG, Cheng E, Berkova Z, Hyser JM, Ciarlet M, Finegold MJ, Conner ME, Estes MK. Rotavirus viremia and extraintestinal viral infection in the neonatal rat model. J Virol. 2006 May; 80(10):4820-32. PMID: 16641274.
      Citations: 46     Fields:    Translation:AnimalsCells
    177. Zeitler CE, Estes MK, Venkataram Prasad BV. X-ray crystallographic structure of the Norwalk virus protease at 1.5-A resolution. J Virol. 2006 May; 80(10):5050-8. PMID: 16641296.
      Citations: 45     Fields:    Translation:Cells
    178. Choi NW, Estes MK, Langridge WH. Synthesis of a ricin toxin B subunit-rotavirus VP7 fusion protein in potato. Mol Biotechnol. 2006 Feb; 32(2):117-28. PMID: 16444013.
      Citations: 6     Fields:    Translation:AnimalsCells
    179. Choi NW, Estes MK, Langridge WH. Ricin toxin B subunit enhancement of rotavirus NSP4 immunogenicity in mice. Viral Immunol. 2006; 19(1):54-63. PMID: 16553550.
      Citations: 3     Fields:    Translation:AnimalsCells
    180. Tanaka T, Kitamoto N, Jiang X, Estes MK. High efficiency cross-reactive monoclonal antibody production by oral immunization with recombinant norwalk virus-like particles. Microbiol Immunol. 2006; 50(11):883-8. PMID: 17116984.
      Citations: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    181. Choi NW, Estes MK, Langridge WH. Synthesis and assembly of a cholera toxin B subunit-rotavirus VP7 fusion protein in transgenic potato. Mol Biotechnol. 2005 Nov; 31(3):193-202. PMID: 16230769.
      Citations: 10     Fields:    Translation:Animals
    182. Choi NW, Estes MK, Langridge WH. Oral immunization with a shiga toxin B subunit: rotavirus NSP4(90) fusion protein protects mice against gastroenteritis. Vaccine. 2005 Oct 25; 23(44):5168-76. PMID: 16040169.
      Citations: 7     Fields:    Translation:AnimalsCellsPHPublic Health
    183. Vizzi E, Calviño E, González R, Pérez-Schael I, Ciarlet M, Kang G, Estes MK, Liprandi F, Ludert JE. Evaluation of serum antibody responses against the rotavirus nonstructural protein NSP4 in children after rhesus rotavirus tetravalent vaccination or natural infection. Clin Diagn Lab Immunol. 2005 Oct; 12(10):1157-63. PMID: 16210477.
      Citations: 7     Fields:    Translation:HumansCells
    184. Choi NW, Estes MK, Langridge WH. Mucosal immunization with a ricin toxin B subunit-rotavirus NSP4 fusion protein stimulates a Th1 lymphocyte response. J Biotechnol. 2006 Jan 24; 121(2):272-83. PMID: 16181698.
      Citations: 10     Fields:    Translation:AnimalsCellsPHPublic Health
    185. Blutt SE, Warfield KL, O'Neal CM, Estes MK, Conner ME. Host, viral, and vaccine factors that determine protective efficacy induced by rotavirus and virus-like particles (VLPs). Vaccine. 2006 Feb 20; 24(8):1170-9. PMID: 16191453.
      Citations: 15     Fields:    Translation:AnimalsCells
    186. Hutson AM, Airaud F, LePendu J, Estes MK, Atmar RL. Norwalk virus infection associates with secretor status genotyped from sera. J Med Virol. 2005 Sep; 77(1):116-20. PMID: 16032732.
      Citations: 66     Fields:    Translation:HumansCells
    187. Asanaka M, Atmar RL, Ruvolo V, Crawford SE, Neill FH, Estes MK. Replication and packaging of Norwalk virus RNA in cultured mammalian cells. Proc Natl Acad Sci U S A. 2005 Jul 19; 102(29):10327-32. PMID: 16002473.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    188. Pesavento JB, Crawford SE, Roberts E, Estes MK, Prasad BV. pH-induced conformational change of the rotavirus VP4 spike: implications for cell entry and antibody neutralization. J Virol. 2005 Jul; 79(13):8572-80. PMID: 15956598.
      Citations: 14     Fields:    Translation:Cells
    189. Parker TD, Kitamoto N, Tanaka T, Hutson AM, Estes MK. Identification of Genogroup I and Genogroup II broadly reactive epitopes on the norovirus capsid. J Virol. 2005 Jun; 79(12):7402-9. PMID: 15919896.
      Citations: 41     Fields:    Translation:HumansCells
    190. Nurgalieva ZZ, Conner ME, Opekun AR, Zheng CQ, Elliott SN, Ernst PB, Osato M, Estes MK, Graham DY. B-cell and T-cell immune responses to experimental Helicobacter pylori infection in humans. Infect Immun. 2005 May; 73(5):2999-3006. PMID: 15845507.
      Citations: 13     Fields:    Translation:HumansCells
    191. Scofield VL, Montufar-Solis D, Cheng E, Estes MK, Klein JR. Intestinal TSH production is localized in crypt enterocytes and in villus 'hotblocks' and is coupled to IL-7 production: evidence for involvement of TSH during acute enteric virus infection. Immunol Lett. 2005 Jun 15; 99(1):36-44. PMID: 15894109.
      Citations: 7     Fields:    Translation:AnimalsCells
    192. Chakravarty S, Hutson AM, Estes MK, Prasad BV. Evolutionary trace residues in noroviruses: importance in receptor binding, antigenicity, virion assembly, and strain diversity. J Virol. 2005 Jan; 79(1):554-68. PMID: 15596848.
      Citations: 27     Fields:    Translation:HumansCells
    193. Moe CL, Sair A, Lindesmith L, Estes MK, Jaykus LA. Diagnosis of norwalk virus infection by indirect enzyme immunoassay detection of salivary antibodies to recombinant norwalk virus antigen. Clin Diagn Lab Immunol. 2004 Nov; 11(6):1028-34. PMID: 15539501.
      Citations: 15     Fields:    Translation:HumansCells
    194. Blutt SE, Crawford SE, Warfield KL, Lewis DE, Estes MK, Conner ME. The VP7 outer capsid protein of rotavirus induces polyclonal B-cell activation. J Virol. 2004 Jul; 78(13):6974-81. PMID: 15194774.
      Citations: 16     Fields:    Translation:AnimalsCells
    195. Huang H, Schroeder F, Estes MK, McPherson T, Ball JM. Interaction(s) of rotavirus non-structural protein 4 (NSP4) C-terminal peptides with model membranes. Biochem J. 2004 Jun 15; 380(Pt 3):723-33. PMID: 15012630.
      Citations: 13     Fields:    Translation:AnimalsCells
    196. Hutson AM, Atmar RL, Estes MK. Norovirus disease: changing epidemiology and host susceptibility factors. Trends Microbiol. 2004 Jun; 12(6):279-87. PMID: 15165606.
      Citations: 84     Fields:    Translation:HumansCells
    197. Chen R, Neill JD, Noel JS, Hutson AM, Glass RI, Estes MK, Prasad BV. Inter- and intragenus structural variations in caliciviruses and their functional implications. J Virol. 2004 Jun; 78(12):6469-79. PMID: 15163740.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    198. Duizer E, Schwab KJ, Neill FH, Atmar RL, Koopmans MPG, Estes MK. Laboratory efforts to cultivate noroviruses. J Gen Virol. 2004 Jan; 85(Pt 1):79-87. PMID: 14718622.
      Citations: 184     Fields:    Translation:HumansAnimalsCells
    199. Bertolotti-Ciarlet A, Crawford SE, Hutson AM, Estes MK. The 3' end of Norwalk virus mRNA contains determinants that regulate the expression and stability of the viral capsid protein VP1: a novel function for the VP2 protein. J Virol. 2003 Nov; 77(21):11603-15. PMID: 14557646.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    200. Blutt SE, Kirkwood CD, Parreño V, Warfield KL, Ciarlet M, Estes MK, Bok K, Bishop RF, Conner ME. Rotavirus antigenaemia and viraemia: a common event? Lancet. 2003 Nov 01; 362(9394):1445-9. PMID: 14602437.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    201. Bertolotti-Ciarlet A, Ciarlet M, Crawford SE, Conner ME, Estes MK. Immunogenicity and protective efficacy of rotavirus 2/6-virus-like particles produced by a dual baculovirus expression vector and administered intramuscularly, intranasally, or orally to mice. Vaccine. 2003 Sep 08; 21(25-26):3885-900. PMID: 12922123.
      Citations: 28     Fields:    Translation:AnimalsCells
    202. Tacket CO, Sztein MB, Losonsky GA, Wasserman SS, Estes MK. Humoral, mucosal, and cellular immune responses to oral Norwalk virus-like particles in volunteers. Clin Immunol. 2003 Sep; 108(3):241-7. PMID: 14499247.
      Citations: 69     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
    203. Glass PJ, Zeng CQ, Estes MK. Two nonoverlapping domains on the Norwalk virus open reading frame 3 (ORF3) protein are involved in the formation of the phosphorylated 35K protein and in ORF3-capsid protein interactions. J Virol. 2003 Mar; 77(6):3569-77. PMID: 12610132.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    204. Hutson AM, Atmar RL, Marcus DM, Estes MK. Norwalk virus-like particle hemagglutination by binding to h histo-blood group antigens. J Virol. 2003 Jan; 77(1):405-15. PMID: 12477845.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    205. Kitamoto N, Tanaka T, Natori K, Takeda N, Nakata S, Jiang X, Estes MK. Cross-reactivity among several recombinant calicivirus virus-like particles (VLPs) with monoclonal antibodies obtained from mice immunized orally with one type of VLP. J Clin Microbiol. 2002 Jul; 40(7):2459-65. PMID: 12089262.
      Citations: 36     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    206. Casola A, Garofalo RP, Crawford SE, Estes MK, Mercurio F, Crowe SE, Brasier AR. Interleukin-8 gene regulation in intestinal epithelial cells infected with rotavirus: role of viral-induced IkappaB kinase activation. Virology. 2002 Jun 20; 298(1):8-19. PMID: 12093168.
      Citations: 17     Fields:    Translation:HumansCells
    207. Hutson AM, Atmar RL, Graham DY, Estes MK. Norwalk virus infection and disease is associated with ABO histo-blood group type. J Infect Dis. 2002 May 01; 185(9):1335-7. PMID: 12001052.
      Citations: 153     Fields:    Translation:HumansCells
    208. Bertolotti-Ciarlet A, White LJ, Chen R, Prasad BV, Estes MK. Structural requirements for the assembly of Norwalk virus-like particles. J Virol. 2002 Apr; 76(8):4044-55. PMID: 11907243.
      Citations: 65     Fields:    Translation:AnimalsCells
    209. Ciarlet M, Ludert JE, Iturriza-Gómara M, Liprandi F, Gray JJ, Desselberger U, Estes MK. Initial interaction of rotavirus strains with N-acetylneuraminic (sialic) acid residues on the cell surface correlates with VP4 genotype, not species of origin. J Virol. 2002 Apr; 76(8):4087-95. PMID: 11907248.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    210. Ciarlet M, Hyser JM, Estes MK. Sequence analysis of the VP4, VP6, VP7, and NSP4 gene products of the bovine rotavirus WC3. Virus Genes. 2002 Mar; 24(2):107-18. PMID: 12018701.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    211. Ciarlet M, Crawford SE, Cheng E, Blutt SE, Rice DA, Bergelson JM, Estes MK. VLA-2 (alpha2beta1) integrin promotes rotavirus entry into cells but is not necessary for rotavirus attachment. J Virol. 2002 Feb; 76(3):1109-23. PMID: 11773387.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    212. Ciarlet M, Conner ME, Finegold MJ, Estes MK. Group A rotavirus infection and age-dependent diarrheal disease in rats: a new animal model to study the pathophysiology of rotavirus infection. J Virol. 2002 Jan; 76(1):41-57. PMID: 11739670.
      Citations: 31     Fields:    Translation:AnimalsCells
    213. Atmar RL, Estes MK. Nonculturable agents of viral gastroenteritis. Clin Microbiol Newsl. 1997 Dec 01; 19(23):177-182. PMID: 32336850.
      Citations:    
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