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Martin Matthew Matzuk

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
DivisionPathology
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Human Genetics
    DivisionMolecular & Human Genetics

    TitleInterim Chair
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pathology & Immunology
    DivisionPathology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pharmacology and Chemical Biology
    DivisionPharmacology


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    U09RG000144     (MATZUK, MARTIN M)Jul 1, 1991 - Sep 29, 2006
    NIH/CSR
    DIVISION OF BIOLOGIC, BASIS OF DISEASE
    Role: Principal Investigator

    K11HD000960     (MATZUK, MARTIN M)Aug 1, 1991 - Jul 31, 1996
    NIH/NICHD
    DEVELOPMENTAL &FUNCTIONAL ROLES OF ACTIVIN &INHIBIN
    Role: Principal Investigator

    R01CA060651     (MATZUK, MARTIN M)Aug 1, 1993 - Feb 28, 2012
    NIH/NCI
    Mouse Models to Study Gonadal Tumor Development
    Role: Principal Investigator

    R01HD032067     (MATZUK, MARTIN M.)Aug 17, 1994 - Jun 30, 2020
    NIH/NICHD
    Bone Morphogenic protein signaling pathways in uterine biology
    Role: Principal Investigator

    R37HD033438     (MATZUK, MARTIN M)May 1, 1996 - Sep 29, 2011
    NIH/NICHD
    ANALYSIS OF REPRODUCTIVE FUNCTION USING TRANSGENIC MICE
    Role: Principal Investigator

    R01HD033438     (MATZUK, MARTIN M)May 1, 1996 - May 31, 2016
    NIH/NICHD
    Analysis of Reproductive Function Using Transgenic Mice
    Role: Principal Investigator

    R03HD037231     (MATZUK, MARTIN M)Dec 15, 1998 - Nov 30, 2000
    NIH/NICHD
    IDENTIFICATION AND ANALYSIS OF NOVEL OVARIAN GENES
    Role: Principal Investigator

    R01HD042500     (MATZUK, MARTIN M)Apr 1, 2003 - Mar 31, 2009
    NIH/NICHD
    Regulation of Key Processes in Oocyte Biology
    Role: Principal Investigator

    U01HD060496     (MATZUK, MARTIN M)Feb 15, 2009 - Jan 31, 2014
    NIH/NICHD
    identification of small molecule contraceptives that target the male germline
    Role: Principal Investigator

    R01HD057880     (MATZUK, MARTIN M)Jul 27, 2009 - Jun 30, 2012
    NIH/NICHD
    Defining the Mammalian Intercellular Bridge Interactome
    Role: Principal Investigator

    R01HD088412     (MATZUK, MARTIN M.)Aug 1, 2016 - May 31, 2021
    NIH/NICHD
    Functional analysis of novel testis-expressed secreted and transmembrane proteins
    Role: Principal Investigator

    P01HD087157     (MATZUK, MARTIN M.)May 1, 2017 - Apr 30, 2022
    NIH/NICHD
    Functional genomics and DEC-Tec to identify germ cell-specific contraceptives
    Role: Principal Investigator

    P20CA221729     (MATZUK, MARTIN M.)Sep 20, 2018 - Aug 31, 2022
    NIH/NCI
    2/2: UHCOP-DLDCCC alliance: Cancer drug discovery/development and education
    Role: Principal Investigator

    P20CA221731     (CHOW, DIANA S-L.)Sep 20, 2018 - Aug 31, 2022
    NIH/NCI
    1/2: UHCOP-DLDCCC alliance: Cancer drug discovery/development and education
    Role: Co-Principal Investigator

    R61HD099722     (MATZUK, MARTIN M.)Sep 13, 2019 - Aug 31, 2021
    NIH/NICHD
    Targeting testis-specific ubiquitin-proteasome pathways for male contraception
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Fujihara Y, Noda T, Kobayashi K, Oji A, Kobayashi S, Matsumura T, Larasati T, Oura S, Kojima-Kita K, Yu Z, Matzuk MM, Ikawa M. Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice. Proc Natl Acad Sci U S A. 2019 Sep 10; 116(37):18498-18506. PMID: 31455729.
      View in: PubMed
    2. Holcomb RJ, Oura S, Nozawa K, Kent K, Yu Z, Robertson MJ, Coarfa C, Matzuk MM, Ikawa M, Garcia TX. The testis-specific serine proteases Prss44, Prss46, and Prss54 are dispensable for mouse fertility. Biol Reprod. 2019 Aug 12. PMID: 31403672.
      View in: PubMed
    3. Lu Y, Oura S, Matsumura T, Oji A, Sakurai N, Fujihara Y, Shimada K, Miyata H, Tobita T, Noda T, Castaneda JM, Kiyozumi D, Zhang Q, Larasati T, Young SAM, Kodani M, Huddleston CA, Robertson MJ, Coarfa C, Isotani A, Aitken RJ, Okabe M, Matzuk MM, Garcia TX, Ikawa M. CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†. Biol Reprod. 2019 Aug 01; 101(2):501-511. PMID: 31201419.
      View in: PubMed
    4. Li JY, Miklossy G, Modukuri RK, Bohren KM, Yu Z, Palaniappan M, Faver JC, Riehle K, Matzuk MM, Simmons N. Palladium-Catalyzed Hydroxycarbonylation of (Hetero)aryl Halides for DNA-Encoded Chemical Library Synthesis. Bioconjug Chem. 2019 Aug 21; 30(8):2209-2215. PMID: 31329429.
      View in: PubMed
    5. Goebel EJ, Corpina RA, Hinck CS, Czepnik M, Castonguay R, Grenha R, Boisvert A, Miklossy G, Fullerton PT, Matzuk MM, Idone VJ, Economides AN, Kumar R, Hinck AP, Thompson TB. Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity. Proc Natl Acad Sci U S A. 2019 Jul 30; 116(31):15505-15513. PMID: 31315975.
      View in: PubMed
    6. Monsivais D, Kriseman M, Creighton CJ, Matzuk MM. Reply to Liu et al.: ALK5-mediated tumor suppressor signaling through SMAD2 and SMAD3 in the uterus. Proc Natl Acad Sci U S A. 2019 May 07; 116(19):9166-9167. PMID: 31068478.
      View in: PubMed
    7. Du HC, Bangs MC, Simmons N, Matzuk MM. Multistep Synthesis of 1,2,4-Oxadiazoles via DNA-Conjugated Aryl Nitrile Substrates. Bioconjug Chem. 2019 May 15; 30(5):1304-1308. PMID: 30964278.
      View in: PubMed
    8. Du HC, Simmons N, Faver JC, Yu Z, Palaniappan M, Riehle K, Matzuk MM. A Mild, DNA-Compatible Nitro Reduction Using B2(OH)4. Org Lett. 2019 04 05; 21(7):2194-2199. PMID: 30860855.
      View in: PubMed
    9. Yeung TL, Sheng J, Leung CS, Li F, Kim J, Ho SY, Matzuk MM, Lu KH, Wong STC, Mok SC. Systematic Identification of Druggable Epithelial-Stromal Crosstalk Signaling Networks in Ovarian Cancer. J Natl Cancer Inst. 2019 Mar 01; 111(3):272-282. PMID: 29860390.
      View in: PubMed
    10. Faver JC, Riehle K, Lancia DR, Milbank JBJ, Kollmann CS, Simmons N, Yu Z, Matzuk MM. Quantitative Comparison of Enrichment from DNA-Encoded Chemical Library Selections. ACS Comb Sci. 2019 02 11; 21(2):75-82. PMID: 30672692.
      View in: PubMed
    11. Monsivais D, Peng J, Kang Y, Matzuk MM. Activin-like kinase 5 (ALK5) inactivation in the mouse uterus results in metastatic endometrial carcinoma. Proc Natl Acad Sci U S A. 2019 02 26; 116(9):3883-3892. PMID: 30655341.
      View in: PubMed
    12. Kriseman M, Monsivais D, Agno J, Masand RP, Creighton CJ, Matzuk MM. Uterine double-conditional inactivation of Smad2 and Smad3 in mice causes endometrial dysregulation, infertility, and uterine cancer. Proc Natl Acad Sci U S A. 2019 02 26; 116(9):3873-3882. PMID: 30651315.
      View in: PubMed
    13. Niedenberger BA, Cook K, Baena V, Serra ND, Velte EK, Agno JE, Litwa KA, Terasaki M, Hermann BP, Matzuk MM, Geyer CB. Dynamic cytoplasmic projections connect mammalian spermatogonia in vivo. Development. 2018 08 13; 145(15). PMID: 29980567.
      View in: PubMed
    14. Walton JB, Farquharson M, Mason S, Port J, Kruspig B, Dowson S, Stevenson D, Murphy D, Matzuk M, Kim J, Coffelt S, Blyth K, McNeish IA. Author Correction: CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity. Sci Rep. 2018 Apr 13; 8(1):6231. PMID: 29651149.
      View in: PubMed
    15. Walton JB, Farquharson M, Mason S, Port J, Kruspig B, Dowson S, Stevenson D, Murphy D, Matzuk M, Kim J, Coffelt S, Blyth K, McNeish IA. CRISPR/Cas9-derived models of ovarian high grade serous carcinoma targeting Brca1, Pten and Nf1, and correlation with platinum sensitivity. Sci Rep. 2017 12 04; 7(1):16827. PMID: 29203787.
      View in: PubMed
    16. Monsivais D, Matzuk MM, Pangas SA. The TGF-ß Family in the Reproductive Tract. Cold Spring Harb Perspect Biol. 2017 Oct 03; 9(10). PMID: 28193725.
      View in: PubMed
    17. Castaneda JM, Hua R, Miyata H, Oji A, Guo Y, Cheng Y, Zhou T, Guo X, Cui Y, Shen B, Wang Z, Hu Z, Zhou Z, Sha J, Prunskaite-Hyyrylainen R, Yu Z, Ramirez-Solis R, Ikawa M, Matzuk MM, Liu M. TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa. Proc Natl Acad Sci U S A. 2017 07 03; 114(27):E5370-E5378. PMID: 28630322.
      View in: PubMed
    18. Jung D, Xiong J, Ye M, Qin X, Li L, Cheng S, Luo M, Peng J, Dong J, Tang F, Shen W, Matzuk MM, Kee K. In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells. Nat Commun. 2017 06 12; 8:15680. PMID: 28604658.
      View in: PubMed
    19. Ogushi S, Yamagata K, Obuse C, Furuta K, Wakayama T, Matzuk MM, Saitou M. Reconstitution of the oocyte nucleolus in mice through a single nucleolar protein, NPM2. J Cell Sci. 2017 Jul 15; 130(14):2416-2429. PMID: 28600324.
      View in: PubMed
    20. Fullerton PT, Monsivais D, Kommagani R, Matzuk MM. Follistatin is critical for mouse uterine receptivity and decidualization. Proc Natl Acad Sci U S A. 2017 06 13; 114(24):E4772-E4781. PMID: 28559342.
      View in: PubMed
    21. Monsivais D, Clementi C, Peng J, Fullerton PT, Prunskaite-Hyyryläinen R, Vainio SJ, Matzuk MM. BMP7 Induces Uterine Receptivity and Blastocyst Attachment. Endocrinology. 2017 04 01; 158(4):979-992. PMID: 28324064.
      View in: PubMed
    22. Iwamori T, Iwamori N, Matsumoto M, Ono E, Matzuk MM. Identification of KIAA1210 as a novel X-chromosome-linked protein that localizes to the acrosome and associates with the ectoplasmic specialization in testes. Biol Reprod. 2017 02 01; 96(2):469-477. PMID: 28203736.
      View in: PubMed
    23. Hua Y, Choi PW, Trachtenberg AJ, Ng AC, Kuo WP, Ng SK, Dinulescu DM, Matzuk MM, Berkowitz RS, Ng SW. Epithelialization of mouse ovarian tumor cells originating in the fallopian tube stroma. Oncotarget. 2016 Oct 04; 7(40):66077-66086. PMID: 27602775.
      View in: PubMed
    24. Iwamori N, Tominaga K, Sato T, Riehle K, Iwamori T, Ohkawa Y, Coarfa C, Ono E, Matzuk MM. MRG15 is required for pre-mRNA splicing and spermatogenesis. Proc Natl Acad Sci U S A. 2016 09 13; 113(37):E5408-15. PMID: 27573846.
      View in: PubMed
    25. Balhara J, Shan L, Zhang J, Muhuri A, Halayko AJ, Almiski MS, Doeing D, McConville J, Matzuk MM, Gounni AS. Pentraxin 3 deletion aggravates allergic inflammation through a TH17-dominant phenotype and enhanced CD4 T-cell survival. J Allergy Clin Immunol. 2017 Mar; 139(3):950-963.e9. PMID: 27567326.
      View in: PubMed
    26. Miyata H, Castaneda JM, Fujihara Y, Yu Z, Archambeault DR, Isotani A, Kiyozumi D, Kriseman ML, Mashiko D, Matsumura T, Matzuk RM, Mori M, Noda T, Oji A, Okabe M, Prunskaite-Hyyrylainen R, Ramirez-Solis R, Satouh Y, Zhang Q, Ikawa M, Matzuk MM. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Proc Natl Acad Sci U S A. 2016 07 12; 113(28):7704-10. PMID: 27357688.
      View in: PubMed
    27. Paine MR, Kim J, Bennett RV, Parry RM, Gaul DA, Wang MD, Matzuk MM, Fernández FM. Whole Reproductive System Non-Negative Matrix Factorization Mass Spectrometry Imaging of an Early-Stage Ovarian Cancer Mouse Model. PLoS One. 2016; 11(5):e0154837. PMID: 27159635.
      View in: PubMed
    28. Monsivais D, Clementi C, Peng J, Titus MM, Barrish JP, Creighton CJ, Lydon JP, DeMayo FJ, Matzuk MM. Uterine ALK3 is essential during the window of implantation. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):E387-95. PMID: 26721398.
      View in: PubMed
    29. Castaneda J, Matzuk MM. DEVELOPMENTAL BIOLOGY. Toward a rapid and reversible male pill. Science. 2015 Oct 23; 350(6259):385-6. PMID: 26494747.
      View in: PubMed
    30. Peng J, Fullerton PT, Monsivais D, Clementi C, Su GH, Matzuk MM. Uterine Activin-Like Kinase 4 Regulates Trophoblast Development During Mouse Placentation. Mol Endocrinol. 2015 Dec; 29(12):1684-93. PMID: 26484579.
      View in: PubMed
    31. Lin H, Matzuk MM. Poreless eggshells. J Clin Invest. 2015 Nov 02; 125(11):4005-7. PMID: 26485282.
      View in: PubMed
    32. Peng J, Monsivais D, You R, Zhong H, Pangas SA, Matzuk MM. Uterine activin receptor-like kinase 5 is crucial for blastocyst implantation and placental development. Proc Natl Acad Sci U S A. 2015 Sep 08; 112(36):E5098-107. PMID: 26305969.
      View in: PubMed
    33. Fullerton PT, Creighton CJ, Matzuk MM. Insights Into SMAD4 Loss in Pancreatic Cancer From Inducible Restoration of TGF-ß Signaling. Mol Endocrinol. 2015 Oct; 29(10):1440-53. PMID: 26284758.
      View in: PubMed
    34. Chen J, Wang Y, McMonechy MK, Anglesio MS, Yang W, Senz J, Maines-Bandiera S, Rosner J, Trigo-Gonzalez G, Grace Cheng SW, Kim J, Matzuk MM, Morin GB, Huntsman DG. Recurrent DICER1 hotspot mutations in endometrial tumours and their impact on microRNA biogenesis. J Pathol. 2015 Oct; 237(2):215-25. PMID: 26033159.
      View in: PubMed
    35. Liu C, Peng J, Matzuk MM, Yao HH. Lineage specification of ovarian theca cells requires multicellular interactions via oocyte and granulosa cells. Nat Commun. 2015 Apr 28; 6:6934. PMID: 25917826.
      View in: PubMed
    36. PrabhuDas M, Bonney E, Caron K, Dey S, Erlebacher A, Fazleabas A, Fisher S, Golos T, Matzuk M, McCune JM, Mor G, Schulz L, Soares M, Spencer T, Strominger J, Way SS, Yoshinaga K. Immune mechanisms at the maternal-fetal interface: perspectives and challenges. Nat Immunol. 2015 Apr; 16(4):328-34. PMID: 25789673.
      View in: PubMed
    37. Kim J, Coffey DM, Ma L, Matzuk MM. The ovary is an alternative site of origin for high-grade serous ovarian cancer in mice. Endocrinology. 2015 Jun; 156(6):1975-81. PMID: 25815421.
      View in: PubMed
    38. Kannan K, Coarfa C, Chao PW, Luo L, Wang Y, Brinegar AE, Hawkins SM, Milosavljevic A, Matzuk MM, Yen L. Recurrent BCAM-AKT2 fusion gene leads to a constitutively activated AKT2 fusion kinase in high-grade serous ovarian carcinoma. Proc Natl Acad Sci U S A. 2015 Mar 17; 112(11):E1272-7. PMID: 25733895.
      View in: PubMed
    39. Jones CM, Monge ME, Kim J, Matzuk MM, Fernández FM. Metabolomic serum profiling detects early-stage high-grade serous ovarian cancer in a mouse model. J Proteome Res. 2015 Feb 06; 14(2):917-27. PMID: 25567202.
      View in: PubMed
    40. Yu Z, Kim J, He L, Creighton CJ, Gunaratne PH, Hawkins SM, Matzuk MM. Functional analysis of miR-34c as a putative tumor suppressor in high-grade serous ovarian cancer. Biol Reprod. 2014 Nov; 91(5):113. PMID: 25273528.
      View in: PubMed
    41. Peng J, Wigglesworth K, Rangarajan A, Eppig JJ, Thompson TB, Matzuk MM. Amino acid 72 of mouse and human GDF9 mature domain is responsible for altered homodimer bioactivities but has subtle effects on GDF9:BMP15 heterodimer activities. Biol Reprod. 2014 Dec; 91(6):142. PMID: 25253739.
      View in: PubMed
    42. Park DH, Hong SJ, Salinas RD, Liu SJ, Sun SW, Sgualdino J, Testa G, Matzuk MM, Iwamori N, Lim DA. Activation of neuronal gene expression by the JMJD3 demethylase is required for postnatal and adult brain neurogenesis. Cell Rep. 2014 Sep 11; 8(5):1290-9. PMID: 25176653.
      View in: PubMed
    43. Archambeault DR, Matzuk MM. Disrupting the male germ line to find infertility and contraception targets. Ann Endocrinol (Paris). 2014 May; 75(2):101-8. PMID: 24793995.
      View in: PubMed
    44. Kannan K, Coarfa C, Rajapakshe K, Hawkins SM, Matzuk MM, Milosavljevic A, Yen L. CDKN2D-WDFY2 is a cancer-specific fusion gene recurrent in high-grade serous ovarian carcinoma. PLoS Genet. 2014 Mar; 10(3):e1004216. PMID: 24675677.
      View in: PubMed
    45. Lin YN, Matzuk MM. Genetics of male fertility. Methods Mol Biol. 2014; 1154:25-37. PMID: 24782004.
      View in: PubMed
    46. Clementi C, Tripurani SK, Large MJ, Edson MA, Creighton CJ, Hawkins SM, Kovanci E, Kaartinen V, Lydon JP, Pangas SA, DeMayo FJ, Matzuk MM. Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans. PLoS Genet. 2013 Nov; 9(11):e1003863. PMID: 24244176.
      View in: PubMed
    47. Wigglesworth K, Lee KB, O'Brien MJ, Peng J, Matzuk MM, Eppig JJ. Bidirectional communication between oocytes and ovarian follicular somatic cells is required for meiotic arrest of mammalian oocytes. Proc Natl Acad Sci U S A. 2013 Sep 24; 110(39):E3723-9. PMID: 23980176.
      View in: PubMed
    48. Iwamori N, Iwamori T, Matzuk MM. H3K27 demethylase, JMJD3, regulates fragmentation of spermatogonial cysts. PLoS One. 2013; 8(8):e72689. PMID: 23967333.
      View in: PubMed
    49. Lim AK, Lorthongpanich C, Chew TG, Tan CW, Shue YT, Balu S, Gounko N, Kuramochi-Miyagawa S, Matzuk MM, Chuma S, Messerschmidt DM, Solter D, Knowles BB. The nuage mediates retrotransposon silencing in mouse primordial ovarian follicles. Development. 2013 Sep; 140(18):3819-25. PMID: 23924633.
      View in: PubMed
    50. Peng J, Li Q, Wigglesworth K, Rangarajan A, Kattamuri C, Peterson RT, Eppig JJ, Thompson TB, Matzuk MM. Reply to Mottershead et al.: GDF9:BMP15 heterodimers are potent regulators of ovarian functions. Proc Natl Acad Sci U S A. 2013 Jun 18; 110(25):E2258. PMID: 23940843.
      View in: PubMed
    51. Wang Q, Liu X, Tang N, Archambeault DR, Li J, Song H, Tang C, He B, Matzuk MM, Wang Y. GASZ promotes germ cell derivation from embryonic stem cells. Stem Cell Res. 2013 Sep; 11(2):845-60. PMID: 23816659.
      View in: PubMed
    52. Nagashima T, Li Q, Clementi C, Lydon JP, DeMayo FJ, Matzuk MM. BMPR2 is required for postimplantation uterine function and pregnancy maintenance. J Clin Invest. 2013 Jun; 123(6):2539-50. PMID: 23676498.
      View in: PubMed
    53. Peng J, Li Q, Wigglesworth K, Rangarajan A, Kattamuri C, Peterson RT, Eppig JJ, Thompson TB, Matzuk MM. Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):E776-85. PMID: 23382188.
      View in: PubMed
    54. Yatsenko AN, Georgiadis AP, Murthy LJ, Lamb DJ, Matzuk MM. UBE2B mRNA alterations are associated with severe oligozoospermia in infertile men. Mol Hum Reprod. 2013 Jun; 19(6):388-94. PMID: 23378580.
      View in: PubMed
    55. Matzuk MM, McKeown MR, Filippakopoulos P, Li Q, Ma L, Agno JE, Lemieux ME, Picaud S, Yu RN, Qi J, Knapp S, Bradner JE. Small-molecule inhibition of BRDT for male contraception. Cell. 2012 Aug 17; 150(4):673-84. PMID: 22901802.
      View in: PubMed
    56. Chen J, Matzuk MM, Zhou XJ, Lu CY. Endothelial pentraxin 3 contributes to murine ischemic acute kidney injury. Kidney Int. 2012 Dec; 82(11):1195-207. PMID: 22895517.
      View in: PubMed
    57. Lee SJ, Huynh TV, Lee YS, Sebald SM, Wilcox-Adelman SA, Iwamori N, Lepper C, Matzuk MM, Fan CM. Role of satellite cells versus myofibers in muscle hypertrophy induced by inhibition of the myostatin/activin signaling pathway. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):E2353-60. PMID: 22869749.
      View in: PubMed
    58. Hawkins SM, Andreu-Vieyra CV, Kim TH, Jeong JW, Hodgson MC, Chen R, Creighton CJ, Lydon JP, Gunaratne PH, DeMayo FJ, Matzuk MM. Dysregulation of uterine signaling pathways in progesterone receptor-Cre knockout of dicer. Mol Endocrinol. 2012 Sep; 26(9):1552-66. PMID: 22798293.
      View in: PubMed
    59. Bonomi L, Brown M, Ungerleider N, Muse M, Matzuk MM, Schneyer A. Activin B regulates islet composition and islet mass but not whole body glucose homeostasis or insulin sensitivity. Am J Physiol Endocrinol Metab. 2012 Sep 01; 303(5):E587-96. PMID: 22739106.
      View in: PubMed
    60. Iwamori N, Iwamori T, Matzuk MM. Characterization of spermatogonial stem cells lacking intercellular bridges and genetic replacement of a mutation in spermatogonial stem cells. PLoS One. 2012; 7(6):e38914. PMID: 22719986.
      View in: PubMed
    61. Kim J, Coffey DM, Creighton CJ, Yu Z, Hawkins SM, Matzuk MM. High-grade serous ovarian cancer arises from fallopian tube in a mouse model. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3921-6. PMID: 22331912.
      View in: PubMed
    62. Matzuk MM, Burns KH. Genetics of mammalian reproduction: modeling the end of the germline. Annu Rev Physiol. 2012; 74:503-28. PMID: 22335799.
      View in: PubMed
    63. Li Q, Agno JE, Edson MA, Nagaraja AK, Nagashima T, Matzuk MM. Transforming growth factor ß receptor type 1 is essential for female reproductive tract integrity and function. PLoS Genet. 2011 Oct; 7(10):e1002320. PMID: 22028666.
      View in: PubMed
    64. Yatsenko AN, O'Neil DS, Roy A, Arias-Mendoza PA, Chen R, Murthy LJ, Lamb DJ, Matzuk MM. Association of mutations in the zona pellucida binding protein 1 (ZPBP1) gene with abnormal sperm head morphology in infertile men. Mol Hum Reprod. 2012 Jan; 18(1):14-21. PMID: 21911476.
      View in: PubMed
    65. Fauser BC, Diedrich K, Bouchard P, Domínguez F, Matzuk M, Franks S, Hamamah S, Simón C, Devroey P, Ezcurra D, Howles CM. Contemporary genetic technologies and female reproduction. Hum Reprod Update. 2011 Nov-Dec; 17(6):829-47. PMID: 21896560.
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    66. Nagashima T, Kim J, Li Q, Lydon JP, DeMayo FJ, Lyons KM, Matzuk MM. Connective tissue growth factor is required for normal follicle development and ovulation. Mol Endocrinol. 2011 Oct; 25(10):1740-59. PMID: 21868453.
      View in: PubMed
    67. Gokoffski KK, Wu HH, Beites CL, Kim J, Kim EJ, Matzuk MM, Johnson JE, Lander AD, Calof AL. Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate. Development. 2011 Oct; 138(19):4131-42. PMID: 21852401.
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    68. Greenbaum MP, Iwamori T, Buchold GM, Matzuk MM. Germ cell intercellular bridges. Cold Spring Harb Perspect Biol. 2011 Aug 01; 3(8):a005850. PMID: 21669984.
      View in: PubMed
    69. Roy A, Matzuk MM. Reproductive tract function and dysfunction in women. Nat Rev Endocrinol. 2011 May 24; 7(9):517-25. PMID: 21610684.
      View in: PubMed
    70. Hawkins SM, Buchold GM, Matzuk MM. Minireview: The roles of small RNA pathways in reproductive medicine. Mol Endocrinol. 2011 Aug; 25(8):1257-79. PMID: 21546411.
      View in: PubMed
    71. Hawkins SM, Creighton CJ, Han DY, Zariff A, Anderson ML, Gunaratne PH, Matzuk MM. Functional microRNA involved in endometriosis. Mol Endocrinol. 2011 May; 25(5):821-32. PMID: 21436257.
      View in: PubMed
    72. Iwamori T, Lin YN, Ma L, Iwamori N, Matzuk MM. Identification and characterization of RBM44 as a novel intercellular bridge protein. PLoS One. 2011 Feb 25; 6(2):e17066. PMID: 21364893.
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    73. Iwamori N, Zhao M, Meistrich ML, Matzuk MM. The testis-enriched histone demethylase, KDM4D, regulates methylation of histone H3 lysine 9 during spermatogenesis in the mouse but is dispensable for fertility. Biol Reprod. 2011 Jun; 84(6):1225-34. PMID: 21293030.
      View in: PubMed
    74. Buchold GM, Coarfa C, Kim J, Milosavljevic A, Gunaratne PH, Matzuk MM. Analysis of microRNA expression in the prepubertal testis. PLoS One. 2010 Dec 29; 5(12):e15317. PMID: 21206922.
      View in: PubMed
    75. Hwang K, Yatsenko AN, Jorgez CJ, Mukherjee S, Nalam RL, Matzuk MM, Lamb DJ. Mendelian genetics of male infertility. Ann N Y Acad Sci. 2010 Dec; 1214:E1-E17. PMID: 21382200.
      View in: PubMed
    76. Sugiura K, Su YQ, Li Q, Wigglesworth K, Matzuk MM, Eppig JJ. Estrogen promotes the development of mouse cumulus cells in coordination with oocyte-derived GDF9 and BMP15. Mol Endocrinol. 2010 Dec; 24(12):2303-14. PMID: 21047911.
      View in: PubMed
    77. Lee SJ, Lee YS, Zimmers TA, Soleimani A, Matzuk MM, Tsuchida K, Cohn RD, Barton ER. Regulation of muscle mass by follistatin and activins. Mol Endocrinol. 2010 Oct; 24(10):1998-2008. PMID: 20810712.
      View in: PubMed
    78. Nagaraja AK, Middlebrook BS, Rajanahally S, Myers M, Li Q, Matzuk MM, Pangas SA. Defective gonadotropin-dependent ovarian folliculogenesis and granulosa cell gene expression in inhibin-deficient mice. Endocrinology. 2010 Oct; 151(10):4994-5006. PMID: 20739397.
      View in: PubMed
    79. Andreu-Vieyra CV, Chen R, Agno JE, Glaser S, Anastassiadis K, Stewart AF, Matzuk MM. MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing. PLoS Biol. 2010 Aug 17; 8(8). PMID: 20808952.
      View in: PubMed
    80. Nalam RL, Andreu-Vieyra C, Matzuk MM. Absence of inhibin alpha and retinoblastoma protein leads to early sertoli cell dysfunction. PLoS One. 2010 Jul 27; 5(7):e11797. PMID: 20676395.
      View in: PubMed
    81. Rajanahally S, Agno JE, Nalam RL, Weinstein MB, Loveland KL, Matzuk MM, Li Q. Genetic evidence that SMAD2 is not required for gonadal tumor development in inhibin-deficient mice. Reprod Biol Endocrinol. 2010 Jun 21; 8:69. PMID: 20565978.
      View in: PubMed
    82. Nalam RL, Matzuk MM. Local signalling environments and human male infertility: what we can learn from mouse models. Expert Rev Mol Med. 2010 May 11; 12:e15. PMID: 20456819.
      View in: PubMed
    83. Su YQ, Sugiura K, Li Q, Wigglesworth K, Matzuk MM, Eppig JJ. Mouse oocytes enable LH-induced maturation of the cumulus-oocyte complex via promoting EGF receptor-dependent signaling. Mol Endocrinol. 2010 Jun; 24(6):1230-9. PMID: 20382892.
      View in: PubMed
    84. Edson MA, Nalam RL, Clementi C, Franco HL, Demayo FJ, Lyons KM, Pangas SA, Matzuk MM. Granulosa cell-expressed BMPR1A and BMPR1B have unique functions in regulating fertility but act redundantly to suppress ovarian tumor development. Mol Endocrinol. 2010 Jun; 24(6):1251-66. PMID: 20363875.
      View in: PubMed
    85. Creighton CJ, Benham AL, Zhu H, Khan MF, Reid JG, Nagaraja AK, Fountain MD, Dziadek O, Han D, Ma L, Kim J, Hawkins SM, Anderson ML, Matzuk MM, Gunaratne PH. Discovery of novel microRNAs in female reproductive tract using next generation sequencing. PLoS One. 2010 Mar 10; 5(3):e9637. PMID: 20224791.
      View in: PubMed
    86. Creighton CJ, Fountain MD, Yu Z, Nagaraja AK, Zhu H, Khan M, Olokpa E, Zariff A, Gunaratne PH, Matzuk MM, Anderson ML. Molecular profiling uncovers a p53-associated role for microRNA-31 in inhibiting the proliferation of serous ovarian carcinomas and other cancers. Cancer Res. 2010 Mar 01; 70(5):1906-15. PMID: 20179198.
      View in: PubMed
    87. Iwamori T, Iwamori N, Ma L, Edson MA, Greenbaum MP, Matzuk MM. TEX14 interacts with CEP55 to block cell abscission. Mol Cell Biol. 2010 May; 30(9):2280-92. PMID: 20176808.
      View in: PubMed
    88. Yatsenko AN, Yatsenko SA, Weedin JW, Lawrence AE, Patel A, Peacock S, Matzuk MM, Lamb DJ, Cheung SW, Lipshultz LI. Comprehensive 5-year study of cytogenetic aberrations in 668 infertile men. J Urol. 2010 Apr; 183(4):1636-42. PMID: 20172548.
      View in: PubMed
    89. Mithraprabhu S, Mendis S, Meachem SJ, Tubino L, Matzuk MM, Brown CW, Loveland KL. Activin bioactivity affects germ cell differentiation in the postnatal mouse testis in vivo. Biol Reprod. 2010 May; 82(5):980-90. PMID: 20130270.
      View in: PubMed
    90. Nagaraja AK, Creighton CJ, Yu Z, Zhu H, Gunaratne PH, Reid JG, Olokpa E, Itamochi H, Ueno NT, Hawkins SM, Anderson ML, Matzuk MM. A link between mir-100 and FRAP1/mTOR in clear cell ovarian cancer. Mol Endocrinol. 2010 Feb; 24(2):447-63. PMID: 20081105.
      View in: PubMed
    91. Edson MA, Lin YN, Matzuk MM. Deletion of the novel oocyte-enriched gene, Gpr149, leads to increased fertility in mice. Endocrinology. 2010 Jan; 151(1):358-68. PMID: 19887567.
      View in: PubMed
    92. Nalam RL, Andreu-Vieyra C, Braun RE, Akiyama H, Matzuk MM. Retinoblastoma protein plays multiple essential roles in the terminal differentiation of Sertoli cells. Mol Endocrinol. 2009 Nov; 23(11):1900-13. PMID: 19819985.
      View in: PubMed
    93. Edson MA, Nagaraja AK, Matzuk MM. The mammalian ovary from genesis to revelation. Endocr Rev. 2009 Oct; 30(6):624-712. PMID: 19776209.
      View in: PubMed
    94. Nalam RL, Lin YN, Matzuk MM. Testicular cell adhesion molecule 1 (TCAM1) is not essential for fertility. Mol Cell Endocrinol. 2010 Feb 05; 315(1-2):246-53. PMID: 19766163.
      View in: PubMed
    95. Ma L, Buchold GM, Greenbaum MP, Roy A, Burns KH, Zhu H, Han DY, Harris RA, Coarfa C, Gunaratne PH, Yan W, Matzuk MM. GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline. PLoS Genet. 2009 Sep; 5(9):e1000635. PMID: 19730684.
      View in: PubMed
    96. Myers M, Middlebrook BS, Matzuk MM, Pangas SA. Loss of inhibin alpha uncouples oocyte-granulosa cell dynamics and disrupts postnatal folliculogenesis. Dev Biol. 2009 Oct 15; 334(2):458-67. PMID: 19666016.
      View in: PubMed
    97. Li Q, Rajanahally S, Edson MA, Matzuk MM. Stable expression and characterization of N-terminal tagged recombinant human bone morphogenetic protein 15. Mol Hum Reprod. 2009 Dec; 15(12):779-88. PMID: 19651638.
      View in: PubMed
    98. Matzuk MM. LIN28 lets BLIMP1 take the right course. Dev Cell. 2009 Aug; 17(2):160-1. PMID: 19686677.
      View in: PubMed
    99. Itman C, Small C, Griswold M, Nagaraja AK, Matzuk MM, Brown CW, Jans DA, Loveland KL. Developmentally regulated SMAD2 and SMAD3 utilization directs activin signaling outcomes. Dev Dyn. 2009 Jul; 238(7):1688-700. PMID: 19517569.
      View in: PubMed
    100. Sugiura K, Su YQ, Li Q, Wigglesworth K, Matzuk MM, Eppig JJ. Fibroblast growth factors and epidermal growth factor cooperate with oocyte-derived members of the TGFbeta superfamily to regulate Spry2 mRNA levels in mouse cumulus cells. Biol Reprod. 2009 Nov; 81(5):833-41. PMID: 19553596.
      View in: PubMed
    101. Roy A, Lin YN, Agno JE, DeMayo FJ, Matzuk MM. Tektin 3 is required for progressive sperm motility in mice. Mol Reprod Dev. 2009 May; 76(5):453-9. PMID: 18951373.
      View in: PubMed
    102. Souza DG, Amaral FA, Fagundes CT, Coelho FM, Arantes RM, Sousa LP, Matzuk MM, Garlanda C, Mantovani A, Dias AA, Teixeira MM. The long pentraxin PTX3 is crucial for tissue inflammation after intestinal ischemia and reperfusion in mice. Am J Pathol. 2009 Apr; 174(4):1309-18. PMID: 19286566.
      View in: PubMed
    103. Licona-Limón P, Alemán-Muench G, Chimal-Monroy J, Macías-Silva M, García-Zepeda EA, Matzuk MM, Fortoul TI, Soldevila G. Activins and inhibins: novel regulators of thymocyte development. Biochem Biophys Res Commun. 2009 Apr 03; 381(2):229-35. PMID: 19338778.
      View in: PubMed
    104. Huang X, Andreu-Vieyra CV, Wang M, Cooney AJ, Matzuk MM, Zhang P. Preimplantation mouse embryos depend on inhibitory phosphorylation of separase to prevent chromosome missegregation. Mol Cell Biol. 2009 Mar; 29(6):1498-505. PMID: 19124608.
      View in: PubMed
    105. Antsiferova M, Klatte JE, Bodó E, Paus R, Jorcano JL, Matzuk MM, Werner S, Kögel H. Keratinocyte-derived follistatin regulates epidermal homeostasis and wound repair. Lab Invest. 2009 Feb; 89(2):131-41. PMID: 19079322.
      View in: PubMed
    106. Greenbaum MP, Iwamori N, Agno JE, Matzuk MM. Mouse TEX14 is required for embryonic germ cell intercellular bridges but not female fertility. Biol Reprod. 2009 Mar; 80(3):449-57. PMID: 19020301.
      View in: PubMed
    107. Shen JJ, Huang L, Li L, Jorgez C, Matzuk MM, Brown CW. Deficiency of growth differentiation factor 3 protects against diet-induced obesity by selectively acting on white adipose. Mol Endocrinol. 2009 Jan; 23(1):113-23. PMID: 19008465.
      View in: PubMed
    108. Li Q, McKenzie LJ, Matzuk MM. Revisiting oocyte-somatic cell interactions: in search of novel intrafollicular predictors and regulators of oocyte developmental competence. Mol Hum Reprod. 2008 Dec; 14(12):673-8. PMID: 18996952.
      View in: PubMed
    109. Matzuk MM, Lamb DJ. The biology of infertility: research advances and clinical challenges. Nat Med. 2008 Nov; 14(11):1197-213. PMID: 18989307.
      View in: PubMed
    110. Creighton CJ, Nagaraja AK, Hanash SM, Matzuk MM, Gunaratne PH. A bioinformatics tool for linking gene expression profiling results with public databases of microRNA target predictions. RNA. 2008 Nov; 14(11):2290-6. PMID: 18812437.
      View in: PubMed
    111. Li Q, Pangas SA, Jorgez CJ, Graff JM, Weinstein M, Matzuk MM. Redundant roles of SMAD2 and SMAD3 in ovarian granulosa cells in vivo. Mol Cell Biol. 2008 Dec; 28(23):7001-11. PMID: 18809571.
      View in: PubMed
    112. Nalam RL, Pletcher SD, Matzuk MM. Appetite for reproduction: dietary restriction, aging and the mammalian gonad. J Biol. 2008 Sep 16; 7(7):23. PMID: 18828876.
      View in: PubMed
    113. Nagaraja AK, Andreu-Vieyra C, Franco HL, Ma L, Chen R, Han DY, Zhu H, Agno JE, Gunaratne PH, DeMayo FJ, Matzuk MM. Deletion of Dicer in somatic cells of the female reproductive tract causes sterility. Mol Endocrinol. 2008 Oct; 22(10):2336-52. PMID: 18687735.
      View in: PubMed
    114. Reid JG, Nagaraja AK, Lynn FC, Drabek RB, Muzny DM, Shaw CA, Weiss MK, Naghavi AO, Khan M, Zhu H, Tennakoon J, Gunaratne GH, Corry DB, Miller J, McManus MT, German MS, Gibbs RA, Matzuk MM, Gunaratne PH. Mouse let-7 miRNA populations exhibit RNA editing that is constrained in the 5'-seed/ cleavage/anchor regions and stabilize predicted mmu-let-7a:mRNA duplexes. Genome Res. 2008 Oct; 18(10):1571-81. PMID: 18614752.
      View in: PubMed
    115. Nagaraja AK, Agno JE, Kumar TR, Matzuk MM. Luteinizing hormone promotes gonadal tumorigenesis in inhibin-deficient mice. Mol Cell Endocrinol. 2008 Nov 06; 294(1-2):19-28. PMID: 18657590.
      View in: PubMed
    116. Andreu-Vieyra C, Chen R, Matzuk MM. Conditional deletion of the retinoblastoma (Rb) gene in ovarian granulosa cells leads to premature ovarian failure. Mol Endocrinol. 2008 Sep; 22(9):2141-61. PMID: 18599617.
      View in: PubMed
    117. Aitken RJ, Baker MA, Doncel GF, Matzuk MM, Mauck CK, Harper MJ. As the world grows: contraception in the 21st century. J Clin Invest. 2008 Apr; 118(4):1330-43. PMID: 18382745.
      View in: PubMed
    118. Huang X, Andreu-Vieyra CV, York JP, Hatcher R, Lu T, Matzuk MM, Zhang P. Inhibitory phosphorylation of separase is essential for genome stability and viability of murine embryonic germ cells. PLoS Biol. 2008 Jan; 6(1):e15. PMID: 18232736.
      View in: PubMed
    119. Hawkins SM, Matzuk MM. The menstrual cycle: basic biology. Ann N Y Acad Sci. 2008; 1135:10-8. PMID: 18574203.
      View in: PubMed
    120. Lu B, Poirier C, Gaspar T, Gratzke C, Harrison W, Busija D, Matzuk MM, Andersson KE, Overbeek PA, Bishop CE. A mutation in the inner mitochondrial membrane peptidase 2-like gene (Immp2l) affects mitochondrial function and impairs fertility in mice. Biol Reprod. 2008 Apr; 78(4):601-10. PMID: 18094351.
      View in: PubMed
    121. Su YQ, Sugiura K, Wigglesworth K, O'Brien MJ, Affourtit JP, Pangas SA, Matzuk MM, Eppig JJ. Oocyte regulation of metabolic cooperativity between mouse cumulus cells and oocytes: BMP15 and GDF9 control cholesterol biosynthesis in cumulus cells. Development. 2008 Jan; 135(1):111-21. PMID: 18045843.
      View in: PubMed
    122. Pangas SA, Li X, Umans L, Zwijsen A, Huylebroeck D, Gutierrez C, Wang D, Martin JF, Jamin SP, Behringer RR, Robertson EJ, Matzuk MM. Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice. Mol Cell Biol. 2008 Jan; 28(1):248-57. PMID: 17967875.
      View in: PubMed
    123. Lin SY, Craythorn RG, O'Connor AE, Matzuk MM, Girling JE, Morrison JR, de Kretser DM. Female infertility and disrupted angiogenesis are actions of specific follistatin isoforms. Mol Endocrinol. 2008 Feb; 22(2):415-29. PMID: 17932109.
      View in: PubMed
    124. Li Q, Kumar R, Underwood K, O'Connor AE, Loveland KL, Seehra JS, Matzuk MM. Prevention of cachexia-like syndrome development and reduction of tumor progression in inhibin-deficient mice following administration of a chimeric activin receptor type II-murine Fc protein. Mol Hum Reprod. 2007 Sep; 13(9):675-83. PMID: 17704537.
      View in: PubMed
    125. Lin YN, Roy A, Yan W, Burns KH, Matzuk MM. Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. Mol Cell Biol. 2007 Oct; 27(19):6794-805. PMID: 17664285.
      View in: PubMed
    126. Pangas SA, Jorgez CJ, Tran M, Agno J, Li X, Brown CW, Kumar TR, Matzuk MM. Intraovarian activins are required for female fertility. Mol Endocrinol. 2007 Oct; 21(10):2458-71. PMID: 17609433.
      View in: PubMed
    127. Li Q, Graff JM, O'Connor AE, Loveland KL, Matzuk MM. SMAD3 regulates gonadal tumorigenesis. Mol Endocrinol. 2007 Oct; 21(10):2472-86. PMID: 17595316.
      View in: PubMed
    128. Sugiura K, Su YQ, Diaz FJ, Pangas SA, Sharma S, Wigglesworth K, O'Brien MJ, Matzuk MM, Shimasaki S, Eppig JJ. Oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells. Development. 2007 Jul; 134(14):2593-603. PMID: 17553902.
      View in: PubMed
    129. Andreu-Vieyra C, Chen R, Matzuk MM. Effects of granulosa cell-specific deletion of Rb in Inha-alpha null female mice. Endocrinology. 2007 Aug; 148(8):3837-49. PMID: 17510234.
      View in: PubMed
    130. Greenbaum MP, Ma L, Matzuk MM. Conversion of midbodies into germ cell intercellular bridges. Dev Biol. 2007 May 15; 305(2):389-96. PMID: 17383626.
      View in: PubMed
    131. Andreu-Vieyra C, Matzuk MM. Epigenetic modifications by Trithorax group proteins during early embryogenesis: do members of Trx-G function as maternal effect genes? Reprod Biomed Online. 2007 Feb; 14(2):201-7. PMID: 17298723.
      View in: PubMed
    132. Roy A, Lin YN, Agno JE, DeMayo FJ, Matzuk MM. Absence of tektin 4 causes asthenozoospermia and subfertility in male mice. FASEB J. 2007 Apr; 21(4):1013-25. PMID: 17244819.
      View in: PubMed
    133. Roy A, Matzuk MM. Society for Reproductive Biology Founders' Lecture 2007. Insights into germ cell biology: from the bench to the clinic. Reprod Fertil Dev. 2007; 19(7):783-91. PMID: 17897580.
      View in: PubMed
    134. Luk JM, Lee NP, Shum CK, Lam BY, Siu AF, Che CM, Tam PC, Cheung AN, Yang ZM, Lin YN, Matzuk MM, Lee KF, Yeung WS. Acrosome-specific gene AEP1: identification, characterization and roles in spermatogenesis. J Cell Physiol. 2006 Dec; 209(3):755-66. PMID: 16924657.
      View in: PubMed
    135. Roy A, Lin YN, Matzuk MM. Shaping the sperm head: an ER enzyme leaves its mark. J Clin Invest. 2006 Nov; 116(11):2860-3. PMID: 17080191.
      View in: PubMed
    136. Yatsenko AN, Roy A, Chen R, Ma L, Murthy LJ, Yan W, Lamb DJ, Matzuk MM. Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization. Hum Mol Genet. 2006 Dec 01; 15(23):3411-9. PMID: 17047026.
      View in: PubMed
    137. Pangas SA, Choi Y, Ballow DJ, Zhao Y, Westphal H, Matzuk MM, Rajkovic A. Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8. Proc Natl Acad Sci U S A. 2006 May 23; 103(21):8090-5. PMID: 16690745.
      View in: PubMed
    138. Andreu-Vieyra C, Lin YN, Matzuk MM. Mining the oocyte transcriptome. Trends Endocrinol Metab. 2006 May-Jun; 17(4):136-43. PMID: 16595178.
      View in: PubMed
    139. Jorgez CJ, De Mayo FJ, Matzuk MM. Inhibin alpha-iCre mice: Cre deleter lines for the gonads, pituitary, and adrenal. Genesis. 2006 Apr; 44(4):183-8. PMID: 16604527.
      View in: PubMed
    140. Ballow D, Meistrich ML, Matzuk M, Rajkovic A. Sohlh1 is essential for spermatogonial differentiation. Dev Biol. 2006 Jun 01; 294(1):161-7. PMID: 16564520.
      View in: PubMed
    141. Greenbaum MP, Yan W, Wu MH, Lin YN, Agno JE, Sharma M, Braun RE, Rajkovic A, Matzuk MM. TEX14 is essential for intercellular bridges and fertility in male mice. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):4982-7. PMID: 16549803.
      View in: PubMed
    142. Pangas SA, Li X, Robertson EJ, Matzuk MM. Premature luteinization and cumulus cell defects in ovarian-specific Smad4 knockout mice. Mol Endocrinol. 2006 Jun; 20(6):1406-22. PMID: 16513794.
      View in: PubMed
    143. Yan C, Elvin JA, Lin YN, Hadsell LA, Wang J, DeMayo FJ, Matzuk MM. Regulation of growth differentiation factor 9 expression in oocytes in vivo: a key role of the E-box. Biol Reprod. 2006 Jun; 74(6):999-1006. PMID: 16495478.
      View in: PubMed
    144. Roy A, Matzuk MM. Deconstructing mammalian reproduction: using knockouts to define fertility pathways. Reproduction. 2006 Feb; 131(2):207-19. PMID: 16452715.
      View in: PubMed
    145. Chen C, Ware SM, Sato A, Houston-Hawkins DE, Habas R, Matzuk MM, Shen MM, Brown CW. The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo. Development. 2006 Jan; 133(2):319-29. PMID: 16368929.
      View in: PubMed
    146. Lee SJ, Reed LA, Davies MV, Girgenrath S, Goad ME, Tomkinson KN, Wright JF, Barker C, Ehrmantraut G, Holmstrom J, Trowell B, Gertz B, Jiang MS, Sebald SM, Matzuk M, Li E, Liang LF, Quattlebaum E, Stotish RL, Wolfman NM. Regulation of muscle growth by multiple ligands signaling through activin type II receptors. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18117-22. PMID: 16330774.
      View in: PubMed
    147. Takayanagi Y, Yoshida M, Bielsky IF, Ross HE, Kawamata M, Onaka T, Yanagisawa T, Kimura T, Matzuk MM, Young LJ, Nishimori K. Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice. Proc Natl Acad Sci U S A. 2005 Nov 01; 102(44):16096-101. PMID: 16249339.
      View in: PubMed
    148. Abu-Elheiga L, Matzuk MM, Kordari P, Oh W, Shaikenov T, Gu Z, Wakil SJ. Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal. Proc Natl Acad Sci U S A. 2005 Aug 23; 102(34):12011-6. PMID: 16103361.
      View in: PubMed
    149. Ma X, Reyna A, Mani SK, Matzuk MM, Kumar TR. Impaired male sexual behavior in activin receptor type II knockout mice. Biol Reprod. 2005 Dec; 73(6):1182-90. PMID: 16093358.
      View in: PubMed
    150. Lin YN, Matzuk MM. High-throughput discovery of germ-cell-specific genes. Semin Reprod Med. 2005 Aug; 23(3):201-12. PMID: 16059826.
      View in: PubMed
    151. Kim J, Wu HH, Lander AD, Lyons KM, Matzuk MM, Calof AL. GDF11 controls the timing of progenitor cell competence in developing retina. Science. 2005 Jun 24; 308(5730):1927-30. PMID: 15976303.
      View in: PubMed
    152. Yan W, Ma L, Stein P, Pangas SA, Burns KH, Bai Y, Schultz RM, Matzuk MM. Mice deficient in oocyte-specific oligoadenylate synthetase-like protein OAS1D display reduced fertility. Mol Cell Biol. 2005 Jun; 25(11):4615-24. PMID: 15899864.
      View in: PubMed
    153. Tominaga K, Matzuk MM, Pereira-Smith OM. MrgX is not essential for cell growth and development in the mouse. Mol Cell Biol. 2005 Jun; 25(12):4873-80. PMID: 15923606.
      View in: PubMed
    154. Pangas SA, Matzuk MM. The art and artifact of GDF9 activity: cumulus expansion and the cumulus expansion-enabling factor. Biol Reprod. 2005 Oct; 73(4):582-5. PMID: 15917343.
      View in: PubMed
    155. Jorgez CJ, Lin YN, Matzuk MM. Genetic manipulations to study reproduction. Mol Cell Endocrinol. 2005 Apr 29; 234(1-2):127-35. PMID: 15836961.
      View in: PubMed
    156. Yang J, Medvedev S, Yu J, Tang LC, Agno JE, Matzuk MM, Schultz RM, Hecht NB. Absence of the DNA-/RNA-binding protein MSY2 results in male and female infertility. Proc Natl Acad Sci U S A. 2005 Apr 19; 102(16):5755-60. PMID: 15824319.
      View in: PubMed
    157. Tominaga K, Kirtane B, Jackson JG, Ikeno Y, Ikeda T, Hawks C, Smith JR, Matzuk MM, Pereira-Smith OM. MRG15 regulates embryonic development and cell proliferation. Mol Cell Biol. 2005 Apr; 25(8):2924-37. PMID: 15798182.
      View in: PubMed
    158. Matzuk MM. Gynecologic diseases get their genes. Nat Med. 2005 Jan; 11(1):24-6. PMID: 15635441.
      View in: PubMed
    159. Pangas SA, Yan W, Matzuk MM, Rajkovic A. Restricted germ cell expression of a gene encoding a novel mammalian HORMA domain-containing protein. Gene Expr Patterns. 2004 Dec; 5(2):257-63. PMID: 15567723.
      View in: PubMed
    160. Su YQ, Wu X, O'Brien MJ, Pendola FL, Denegre JN, Matzuk MM, Eppig JJ. Synergistic roles of BMP15 and GDF9 in the development and function of the oocyte-cumulus cell complex in mice: genetic evidence for an oocyte-granulosa cell regulatory loop. Dev Biol. 2004 Dec 01; 276(1):64-73. PMID: 15531364.
      View in: PubMed
    161. Ma X, Dong Y, Matzuk MM, Kumar TR. Targeted disruption of luteinizing hormone beta-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility. Proc Natl Acad Sci U S A. 2004 Dec 07; 101(49):17294-9. PMID: 15569941.
      View in: PubMed
    162. Matzuk MM. Germ-line immortality. Proc Natl Acad Sci U S A. 2004 Nov 23; 101(47):16395-6. PMID: 15546980.
      View in: PubMed
    163. De La Fuente R, Viveiros MM, Burns KH, Adashi EY, Matzuk MM, Eppig JJ. Major chromatin remodeling in the germinal vesicle (GV) of mammalian oocytes is dispensable for global transcriptional silencing but required for centromeric heterochromatin function. Dev Biol. 2004 Nov 15; 275(2):447-58. PMID: 15501230.
      View in: PubMed
    164. Combelles CM, Carabatsos MJ, Kumar TR, Matzuk MM, Albertini DF. Hormonal control of somatic cell oocyte interactions during ovarian follicle development. Mol Reprod Dev. 2004 Nov; 69(3):347-55. PMID: 15349847.
      View in: PubMed
    165. Wang XP, Suomalainen M, Jorgez CJ, Matzuk MM, Werner S, Thesleff I. Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signaling and ameloblast differentiation. Dev Cell. 2004 Nov; 7(5):719-30. PMID: 15525533.
      View in: PubMed
    166. Pangas SA, Matzuk MM. Genetic models for transforming growth factor beta superfamily signaling in ovarian follicle development. Mol Cell Endocrinol. 2004 Oct 15; 225(1-2):83-91. PMID: 15451572.
      View in: PubMed
    167. Tominaga K, Magee DM, Matzuk MM, Pereira-Smith OM. PAM14, a novel MRG- and Rb-associated protein, is not required for development and T-cell function in mice. Mol Cell Biol. 2004 Oct; 24(19):8366-73. PMID: 15367658.
      View in: PubMed
    168. Wang XP, Suomalainen M, Jorgez CJ, Matzuk MM, Wankell M, Werner S, Thesleff I. Modulation of activin/bone morphogenetic protein signaling by follistatin is required for the morphogenesis of mouse molar teeth. Dev Dyn. 2004 Sep; 231(1):98-108. PMID: 15305290.
      View in: PubMed
    169. Rajkovic A, Pangas SA, Ballow D, Suzumori N, Matzuk MM. NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression. Science. 2004 Aug 20; 305(5687):1157-9. PMID: 15326356.
      View in: PubMed
    170. Tang W, Ingalls CP, Durham WJ, Snider J, Reid MB, Wu G, Matzuk MM, Hamilton SL. Altered excitation-contraction coupling with skeletal muscle specific FKBP12 deficiency. FASEB J. 2004 Oct; 18(13):1597-9. PMID: 15289441.
      View in: PubMed
    171. Yao HH, Matzuk MM, Jorgez CJ, Menke DB, Page DC, Swain A, Capel B. Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. Dev Dyn. 2004 Jun; 230(2):210-5. PMID: 15162500.
      View in: PubMed
    172. Yan W, Ma L, Burns KH, Matzuk MM. Haploinsufficiency of kelch-like protein homolog 10 causes infertility in male mice. Proc Natl Acad Sci U S A. 2004 May 18; 101(20):7793-8. PMID: 15136734.
      View in: PubMed
    173. Pangas SA, Jorgez CJ, Matzuk MM. Growth differentiation factor 9 regulates expression of the bone morphogenetic protein antagonist gremlin. J Biol Chem. 2004 Jul 30; 279(31):32281-6. PMID: 15133038.
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    174. Wu X, Chen L, Brown CA, Yan C, Matzuk MM. Interrelationship of growth differentiation factor 9 and inhibin in early folliculogenesis and ovarian tumorigenesis in mice. Mol Endocrinol. 2004 Jun; 18(6):1509-19. PMID: 15016837.
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    175. Roy A, Yan W, Burns KH, Matzuk MM. Tektin3 encodes an evolutionarily conserved putative testicular microtubules-related protein expressed preferentially in male germ cells. Mol Reprod Dev. 2004 Mar; 67(3):295-302. PMID: 14735490.
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    176. Yan W, Ma L, Zilinski CA, Matzuk MM. Identification and characterization of evolutionarily conserved pufferfish, zebrafish, and frog orthologs of GASZ. Biol Reprod. 2004 Jun; 70(6):1619-25. PMID: 14766731.
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    177. Jorgez CJ, Klysik M, Jamin SP, Behringer RR, Matzuk MM. Granulosa cell-specific inactivation of follistatin causes female fertility defects. Mol Endocrinol. 2004 Apr; 18(4):953-67. PMID: 14701941.
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    178. Kumar TR, Agno J, Janovick JA, Conn PM, Matzuk MM. Regulation of FSHbeta and GnRH receptor gene expression in activin receptor II knockout male mice. Mol Cell Endocrinol. 2003 Dec 30; 212(1-2):19-27. PMID: 14654247.
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    179. Brown CW, Li L, Houston-Hawkins DE, Matzuk MM. Activins are critical modulators of growth and survival. Mol Endocrinol. 2003 Dec; 17(12):2404-17. PMID: 14551263.
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    180. Yan W, Ma L, Burns KH, Matzuk MM. HILS1 is a spermatid-specific linker histone H1-like protein implicated in chromatin remodeling during mammalian spermiogenesis. Proc Natl Acad Sci U S A. 2003 Sep 02; 100(18):10546-51. PMID: 12920187.
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    181. Burns KH, Agno JE, Sicinski P, Matzuk MM. Cyclin D2 and p27 are tissue-specific regulators of tumorigenesis in inhibin alpha knockout mice. Mol Endocrinol. 2003 Oct; 17(10):2053-69. PMID: 12855747.
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    182. Burns KH, Agno JE, Chen L, Haupt B, Ogbonna SC, Korach KS, Matzuk MM. Sexually dimorphic roles of steroid hormone receptor signaling in gonadal tumorigenesis. Mol Endocrinol. 2003 Oct; 17(10):2039-52. PMID: 12855748.
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    183. Bernard DJ, Burns KH, Haupt B, Matzuk MM, Woodruff TK. Normal reproductive function in InhBP/p120-deficient mice. Mol Cell Biol. 2003 Jul; 23(14):4882-91. PMID: 12832474.
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    184. Burns KH, Owens GE, Ogbonna SC, Nilson JH, Matzuk MM. Expression profiling analyses of gonadotropin responses and tumor development in the absence of inhibins. Endocrinology. 2003 Oct; 144(10):4492-507. PMID: 12959983.
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    185. Yan W, Assadi AH, Wynshaw-Boris A, Eichele G, Matzuk MM, Clark GD. Previously uncharacterized roles of platelet-activating factor acetylhydrolase 1b complex in mouse spermatogenesis. Proc Natl Acad Sci U S A. 2003 Jun 10; 100(12):7189-94. PMID: 12775763.
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    186. Wu X, Wang P, Brown CA, Zilinski CA, Matzuk MM. Zygote arrest 1 (Zar1) is an evolutionarily conserved gene expressed in vertebrate ovaries. Biol Reprod. 2003 Sep; 69(3):861-7. PMID: 12773403.
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    187. Chirala SS, Chang H, Matzuk M, Abu-Elheiga L, Mao J, Mahon K, Finegold M, Wakil SJ. Fatty acid synthesis is essential in embryonic development: fatty acid synthase null mutants and most of the heterozygotes die in utero. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6358-63. PMID: 12738878.
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    188. Wu MH, Rajkovic A, Burns KH, Yan W, Lin YN, Matzuk MM. Sequence and expression of testis-expressed gene 14 (Tex14): a gene encoding a protein kinase preferentially expressed during spermatogenesis. Gene Expr Patterns. 2003 May; 3(2):231-6. PMID: 12711554.
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    189. Burns KH, Viveiros MM, Ren Y, Wang P, DeMayo FJ, Frail DE, Eppig JJ, Matzuk MM. Roles of NPM2 in chromatin and nucleolar organization in oocytes and embryos. Science. 2003 Apr 25; 300(5619):633-6. PMID: 12714744.
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    190. Matzuk MM, DeMayo FJ, Hadsell LA, Kumar TR. Overexpression of human chorionic gonadotropin causes multiple reproductive defects in transgenic mice. Biol Reprod. 2003 Jul; 69(1):338-46. PMID: 12672665.
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    191. Wu X, Viveiros MM, Eppig JJ, Bai Y, Fitzpatrick SL, Matzuk MM. Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the oocyte-to-embryo transition. Nat Genet. 2003 Feb; 33(2):187-91. PMID: 12539046.
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    192. Suzumori N, Burns KH, Yan W, Matzuk MM. RFPL4 interacts with oocyte proteins of the ubiquitin-proteasome degradation pathway. Proc Natl Acad Sci U S A. 2003 Jan 21; 100(2):550-5. PMID: 12525704.
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    193. Nakamura M, Matzuk MM, Gerstmayer B, Bosio A, Lauster R, Miyachi Y, Werner S, Paus R. Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin. FASEB J. 2003 Mar; 17(3):497-9. PMID: 12514121.
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    194. Lukas-Croisier C, Lasala C, Nicaud J, Bedecarrás P, Kumar TR, Dutertre M, Matzuk MM, Picard JY, Josso N, Rey R. Follicle-stimulating hormone increases testicular Anti-Mullerian hormone (AMH) production through sertoli cell proliferation and a nonclassical cyclic adenosine 5'-monophosphate-mediated activation of the AMH Gene. Mol Endocrinol. 2003 Apr; 17(4):550-61. PMID: 12554789.
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    195. Yan W, Burns KH, Matzuk MM. Genetic engineering to study testicular tumorigenesis. APMIS. 2003 Jan; 111(1):174-81; discussion 182-3. PMID: 12760377.
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    196. Chang H, Brown CW, Matzuk MM. Genetic analysis of the mammalian transforming growth factor-beta superfamily. Endocr Rev. 2002 Dec; 23(6):787-823. PMID: 12466190.
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    197. Matzuk MM, Lamb DJ. Genetic dissection of mammalian fertility pathways. Nat Cell Biol. 2002 Oct; 4 Suppl:s41-9. PMID: 12479614.
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    198. Yan W, Burns KH, Ma L, Matzuk MM. Identification of Zfp393, a germ cell-specific gene encoding a novel zinc finger protein. Mech Dev. 2002 Oct; 118(1-2):233-9. PMID: 12351194.
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    199. Harlow CR, Davidson L, Burns KH, Yan C, Matzuk MM, Hillier SG. FSH and TGF-beta superfamily members regulate granulosa cell connective tissue growth factor gene expression in vitro and in vivo. Endocrinology. 2002 Sep; 143(9):3316-25. PMID: 12193543.
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    200. Burns KH, Owens GE, Fernandez JM, Nilson JH, Matzuk MM. Characterization of integrin expression in the mouse ovary. Biol Reprod. 2002 Sep; 67(3):743-51. PMID: 12193380.
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    201. Burns KH, Matzuk MM. Minireview: genetic models for the study of gonadotropin actions. Endocrinology. 2002 Aug; 143(8):2823-35. PMID: 12130545.
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    202. Matzuk MM, Burns KH, Viveiros MM, Eppig JJ. Intercellular communication in the mammalian ovary: oocytes carry the conversation. Science. 2002 Jun 21; 296(5576):2178-80. PMID: 12077402.
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    203. Varani S, Elvin JA, Yan C, DeMayo J, DeMayo FJ, Horton HF, Byrne MC, Matzuk MM. Knockout of pentraxin 3, a downstream target of growth differentiation factor-9, causes female subfertility. Mol Endocrinol. 2002 Jun; 16(6):1154-67. PMID: 12040004.
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    204. Yan W, Rajkovic A, Viveiros MM, Burns KH, Eppig JJ, Matzuk MM. Identification of Gasz, an evolutionarily conserved gene expressed exclusively in germ cells and encoding a protein with four ankyrin repeats, a sterile-alpha motif, and a basic leucine zipper. Mol Endocrinol. 2002 Jun; 16(6):1168-84. PMID: 12040005.
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    205. Rajkovic A, Yan C, Yan W, Klysik M, Matzuk MM. Obox, a family of homeobox genes preferentially expressed in germ cells. Genomics. 2002 May; 79(5):711-7. PMID: 11991721.
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    206. Rajkovic A, Lee JH, Yan C, Matzuk MM. The ret finger protein-like 4 gene, Rfpl4, encodes a putative E3 ubiquitin-protein ligase expressed in adult germ cells. Mech Dev. 2002 Mar; 112(1-2):173-7. PMID: 11850190.
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    207. Rajkovic A, Matzuk MM. Functional analysis of oocyte-expressed genes using transgenic models. Mol Cell Endocrinol. 2002 Feb 22; 187(1-2):5-9. PMID: 11988305.
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    208. Suzumori N, Yan C, Matzuk MM, Rajkovic A. Nobox is a homeobox-encoding gene preferentially expressed in primordial and growing oocytes. Mech Dev. 2002 Feb; 111(1-2):137-41. PMID: 11804785.
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    209. Wu X, Matzuk MM. GDF-9 and BMP-15: oocyte organizers. Rev Endocr Metab Disord. 2002 Jan; 3(1):27-32. PMID: 11883102.
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    210. Rajkovic A, Yan M S C, Klysik M, Matzuk M. Discovery of germ cell-specific transcripts by expressed sequence tag database analysis. Fertil Steril. 2001 Sep; 76(3):550-4. PMID: 11532480.
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    211. Ben-Arie N, Hassan BA, Bermingham NA, Malicki DM, Armstrong D, Matzuk M, Bellen HJ, Zoghbi HY. Functional conservation of atonal and Math1 in the CNS and PNS. Development. 2000 Mar; 127(5):1039-48. PMID: 10662643.
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