InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
Houston, TX 77030
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    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Virology & Microbiology
    DivisionMolecular Virology & Microbiology

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    2RO1AI078314-06A1     (Sara Lustigman)Apr 11, 2017 - Feb 28, 2022
    New York Blood Center
    TEh Development of a recombinant vaccine against onchocerciasis
    Role: BCM Principal Invvestigator

    W81XWH-17-2-0050     (Peter Hotez)Sep 15, 2017 - Sep 14, 2020
    A vaccine to prevent leishmaniasis
    Role: Co-Investigator

         (Peter Hotez)Nov 1, 2018 - Oct 31, 2022
    Phase I/IIb Testing of the Sm-TSP-2 Schistosomiasis Vaccine in Uganda
    Role: Project Leader

    R13AI142711     (BOTTAZZI, MARIA ELENA)Feb 6, 2019 - Apr 30, 2019
    2019 Tropical Infectious Diseases
    Role: Principal Investigator

         (Peter Hotez)Apr 1, 2019 - Mar 31, 2021
    A novel mucosal trichuriasis vaccine for TH2 immune protection
    Role: Co-Investigator

    R21AI144891     (LIN, YI-PIN)Feb 1, 2020 - Jan 31, 2022
    Identification of the mechanism of protection against a B. burgdorferi protein CspZ for the prevention of Lyme disease
    Role: Co-Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pritchard DI, Diemert D, Bottazzi ME, Hawdon JM, Correa-Oliveira R, Bethony JM. Controlled Infection of Humans with the Hookworm Parasite Necator americanus to Accelerate Vaccine Development : The Human Hookworm Vaccination/Challenge Model (HVCM). Curr Top Microbiol Immunol. 2021 Jul 31. PMID: 34328562.
    2. Pino M, Abid T, Pereira Ribeiro S, Edara VV, Floyd K, Smith JC, Latif MB, Pacheco-Sanchez G, Dutta D, Wang S, Gumber S, Kirejczyk S, Cohen J, Stammen RL, Jean SM, Wood JS, Connor-Stroud F, Pollet J, Chen WH, Wei J, Zhan B, Lee J, Liu Z, Strych U, Shenvi N, Easley K, Weiskopf D, Sette A, Pollara J, Mielke D, Gao H, Eisel N, LaBranche CC, Shen X, Ferrari G, Tomaras GD, Montefiori DC, Sekaly RP, Vanderford TH, Tomai MA, Fox CB, Suthar MS, Kozlowski PA, Hotez PJ, Paiardini M, Bottazzi ME, Kasturi SP. A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates. Sci Immunol. 2021 07 15; 6(61). PMID: 34266981.
      Citations:    Fields:    
    3. Pollet J, Strych U, Chen WH, Versteeg L, Keegan B, Zhan B, Wei J, Liu Z, Lee J, Kundu R, Adhikari R, Poveda C, Villar MJ, Lopez B, Gillespie PM, Ronca S, Kimata JT, Reers M, Paradkar V, Hotez PJ, Bottazzi ME. Receptor-binding domain recombinant protein RBD219-N1C1 on alum-CpG induces broad protection against SARS-CoV-2 variants of concern. bioRxiv. 2021 Jul 07. PMID: 34268512.
      Citations: 1     
    4. Li G, Hoeweler L, Keegan B, Peng J, Scholte L, Hotez P, Bottazzi ME, Diemert D, Bethony J. Potency testing for a recombinant protein vaccine early in clinical development: Lessons from the Schistosoma mansoni Tetraspanin 2 vaccine. Vaccine X. 2021 Aug; 8:100100. PMID: 34169270.
    5. Naniche D, Hotez P, Bottazzi ME, Ergonul O, Figueroa JP, Gilbert S, Gursel M, Hassanain M, Kang G, Kaslow D, Kim JH, Lall B, Larson H, Sheahan T, Shoham S, Wilder-Smith A, Sow SO, Strub-Wourgaft N, Yadav P, Batista C. Beyond the jab: A need for global coordination of pharmacovigilance for COVID-19 vaccine deployment. EClinicalMedicine. 2021 Jun; 36:100925. PMID: 34099998.
    6. Batista C, Shoham S, Ergonul O, Hotez P, Bottazzi ME, Figueroa JP, Gilbert S, Gursel M, Hassanain M, Kang G, Kaslow D, Kim JH, Lall B, Larson H, Naniche D, Sheahan T, Wilder-Smith A, Sow SO, Yadav P, Strub-Wourgaft N. Urgent needs to accelerate the race for COVID-19 therapeutics. EClinicalMedicine. 2021 Jun; 36:100911. PMID: 34036254.
    7. Nanishi E, Borriello F, O'Meara TR, McGrath ME, Saito Y, Haupt RE, Seo HS, van Haren SD, Brook B, Chen J, Diray-Arce J, Doss-Gollin S, Leon M, Chew K, Menon M, Song K, Xu AZ, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Sherman AC, Baden LR, Ernst RK, Dillen C, Weston SM, Johnson RM, Hammond HL, Mayer R, Burke A, Bottazzi ME, Hotez PJ, Strych U, Chang A, Yu J, Barouch DH, Dhe-Paganon S, Zanoni I, Ozonoff A, Frieman MB, Levy O, Dowling DJ. Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity. bioRxiv. 2021 May 21. PMID: 34031655.
    8. Lee J, Liu Z, Chen WH, Wei J, Kundu R, Adhikari R, Rivera JA, Gillespie PM, Strych U, Zhan B, Hotez PJ, Bottazzi ME. Process development and scale-up optimization of the SARS-CoV-2 receptor binding domain-based vaccine candidate, RBD219-N1C1. Appl Microbiol Biotechnol. 2021 May; 105(10):4153-4165. PMID: 33959781.
      Citations:    Fields:    Translation:HumansAnimals
    9. Bartsch SM, Wedlock PT, O'Shea KJ, Cox SN, Strych U, Nuzzo JB, Ferguson MC, Bottazzi ME, Siegmund SS, Hotez PJ, Lee BY. Lives and Costs Saved by Expanding and Expediting COVID-19 Vaccination. J Infect Dis. 2021 May 06. PMID: 33954775.
      Citations: 1     Fields:    
    10. Pollet J, Chen WH, Versteeg L, Keegan B, Zhan B, Wei J, Liu Z, Lee J, Kundu R, Adhikari R, Poveda C, Villar MJ, de Araujo Leao AC, Altieri Rivera J, Momin Z, Gillespie PM, Kimata JT, Strych U, Hotez PJ, Bottazzi ME. SARS-CoV-2 RBD219-N1C1: A yeast-expressed SARS-CoV-2 recombinant receptor-binding domain candidate vaccine stimulates virus neutralizing antibodies and T-cell immunity in mice. Hum Vaccin Immunother. 2021 Apr 13; 1-11. PMID: 33847226.
      Citations: 3     Fields:    
    11. Hoffman K, Liu Z, Hossain E, Bottazzi ME, Hotez PJ, Jones KM, McCall LI. Alterations to the Cardiac Metabolome Induced by Chronic T. cruzi Infection Relate to the Degree of Cardiac Pathology. ACS Infect Dis. 2021 06 11; 7(6):1638-1649. PMID: 33843195.
      Citations: 2     Fields:    Translation:HumansAnimals
    12. Hayon J, Weatherhead J, Hotez PJ, Bottazzi ME, Zhan B. Advances in vaccine development for human trichuriasis. Parasitology. 2021 Mar 24; 1-12. PMID: 33757603.
      Citations:    Fields:    
    13. Chen WH, Wei J, Kundu RT, Adhikari R, Liu Z, Lee J, Versteeg L, Poveda C, Keegan B, Villar MJ, de Araujo Leao AC, Rivera JA, Gillespie PM, Pollet J, Strych U, Zhan B, Hotez PJ, Bottazzi ME. Genetic modification to design a stable yeast-expressed recombinant SARS-CoV-2 receptor binding domain as a COVID-19 vaccine candidate. Biochim Biophys Acta Gen Subj. 2021 06; 1865(6):129893. PMID: 33731300.
      Citations: 4     Fields:    Translation:AnimalsCells
    14. Hotez P, Batista C, Ergonul O, Figueroa JP, Gilbert S, Gursel M, Hassanain M, Kang G, Kim JH, Lall B, Larson H, Naniche D, Sheahan T, Shoham S, Wilder-Smith A, Strub-Wourgaft N, Yadav P, Bottazzi ME. Correcting COVID-19 vaccine misinformation: Lancet Commission on COVID-19 Vaccines and Therapeutics Task Force Members. EClinicalMedicine. 2021 Mar; 33:100780. PMID: 33718854.
      Citations: 1     
    15. Talavera-López C, Messenger LA, Lewis MD, Yeo M, Reis-Cunha JL, Matos GM, Bartholomeu DC, Calzada JE, Saldaña A, Ramírez JD, Guhl F, Ocaña-Mayorga S, Costales JA, Gorchakov R, Jones K, Nolan MS, Teixeira SMR, Carrasco HJ, Bottazzi ME, Hotez PJ, Murray KO, Grijalva MJ, Burleigh B, Grisard EC, Miles MA, Andersson B. Repeat-Driven Generation of Antigenic Diversity in a Major Human Pathogen, Trypanosoma cruzi. Front Cell Infect Microbiol. 2021; 11:614665. PMID: 33747978.
      Citations: 1     Fields:    Translation:Animals
    16. Cruz-Chan JV, Villanueva-Lizama LE, Versteeg L, Damania A, Villar MJ, González-López C, Keegan B, Pollet J, Gusovsky F, Hotez PJ, Bottazzi ME, Jones KM. Vaccine-linked chemotherapy induces IL-17 production and reduces cardiac pathology during acute Trypanosoma cruzi infection. Sci Rep. 2021 Feb 05; 11(1):3222. PMID: 33547365.
      Citations: 1     Fields:    
    17. Ryan NM, Hess JA, de Villena FP, Leiby BE, Shimada A, Yu L, Yarmahmoodi A, Petrovsky N, Zhan B, Bottazzi ME, Makepeace BL, Lustigman S, Abraham D. Onchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice. NPJ Vaccines. 2021 Jan 26; 6(1):17. PMID: 33500417.
      Citations: 1     
    18. Bartsch SM, O'Shea KJ, Wedlock PT, Strych U, Ferguson MC, Bottazzi ME, Randall SL, Siegmund SS, Cox SN, Hotez PJ, Lee BY. The Benefits of Vaccinating With the First Available COVID-19 Coronavirus Vaccine. Am J Prev Med. 2021 05; 60(5):605-613. PMID: 33632650.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    19. Clark EH, Fredricks K, Woc-Colburn L, Bottazzi ME, Weatherhead J. Preparing for SARS-CoV-2 Vaccines in US Immigrant Communities: Strategies for Allocation, Distribution, and Communication. Am J Public Health. 2021 Apr; 111(4):577-581. PMID: 33351664.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    20. Hotez PJ, Huete-Perez JA, Bottazzi ME. COVID-19 in the Americas and the erosion of human rights for the poor. PLoS Negl Trop Dis. 2020 12; 14(12):e0008954. PMID: 33338042.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    21. de Castro JC, de Almeida LV, Cardoso MS, Oliveira FMS, Nogueira DS, Reis-Cunha JL, Magalhaes LMD, Zhan B, Bottazzi ME, Hotez PJ, Bueno LL, Bartholomeu DC, Fujiwara RT. Vaccination with chimeric protein induces protection in murine model against ascariasis. Vaccine. 2021 01 08; 39(2):394-401. PMID: 33248854.
      Citations:    Fields:    Translation:AnimalsPHPublic Health
    22. Poveda C, Bottazzi ME, Jones KM. Mining the Metabolome for New and Innovative Chagas Disease Treatments. Trends Pharmacol Sci. 2021 01; 42(1):1-3. PMID: 33248705.
      Citations: 1     Fields:    Translation:HumansAnimals
    23. Pollet J, Chen WH, Versteeg L, Keegan B, Zhan B, Wei J, Liu Z, Lee J, Kundu R, Adhikari R, Poveda C, Villar MJ, de Araujo Leao AC, Rivera JA, Momin Z, Gillespie PM, Kimata JT, Strych U, Hotez PJ, Bottazzi ME. SARS-CoV-2 RBD219-N1C1: A Yeast-Expressed SARS-CoV-2 Recombinant Receptor-Binding Domain Candidate Vaccine Stimulates Virus Neutralizing Antibodies and T-cell Immunity in Mice. bioRxiv. 2020 Nov 05. PMID: 33173864.
      Citations: 3     
    24. Weatherhead JE, Gazzinelli-Guimaraes P, Knight JM, Fujiwara R, Hotez PJ, Bottazzi ME, Corry DB. Host Immunity and Inflammation to Pulmonary Helminth Infections. Front Immunol. 2020; 11:594520. PMID: 33193446.
      Citations:    Fields:    Translation:HumansAnimals
    25. Hotez P, Bottazzi ME, Strub-Wourgaft N, Sosa-Estani S, Torrico F, Pajín L, Abril M, Sancho J. A new patient registry for Chagas disease. PLoS Negl Trop Dis. 2020 10; 14(10):e0008418. PMID: 33001966.
      Citations:    Fields:    Translation:HumansAnimals
    26. Chen WH, Tao X, Agrawal AS, Algaissi A, Peng BH, Pollet J, Strych U, Bottazzi ME, Hotez PJ, Lustigman S, Du L, Jiang S, Tseng CK. Yeast-expressed SARS-CoV recombinant receptor-binding domain (RBD219-N1) formulated with aluminum hydroxide induces protective immunity and reduces immune enhancement. Vaccine. 2020 11 03; 38(47):7533-7541. PMID: 33039209.
      Citations: 17     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    27. Adegnika AA, de Vries SG, Zinsou FJ, Honkepehedji YJ, Dejon Agobé JC, Vodonou KG, Bikangui R, Bouyoukou Hounkpatin A, Bache EB, Massinga Loembe M, van Leeuwen R, Molemans M, Kremsner PG, Yazdanbakhsh M, Hotez PJ, Bottazzi ME, Li G, Bethony JM, Diemert DJ, Grobusch MP. Safety and immunogenicity of co-administered hookworm vaccine candidates Na-GST-1 and Na-APR-1 in Gabonese adults: a randomised, controlled, double-blind, phase 1 dose-escalation trial. Lancet Infect Dis. 2021 02; 21(2):275-285. PMID: 32926834.
      Citations: 1     Fields:    Translation:HumansAnimalsCTClinical Trials
    28. Liu Z, Kundu R, Damena S, Biter AB, Nyon MP, Chen WH, Zhan B, Strych U, Hotez PJ, Bottazzi ME. A scalable and reproducible manufacturing process for Phlebotomus papatasi salivary protein PpSP15, a vaccine candidate for leishmaniasis. Protein Expr Purif. 2021 01; 177:105750. PMID: 32920041.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    29. Mejia R, Hotez P, Bottazzi ME. Global COVID-19 Efforts as the Platform to Achieving the Sustainable Development Goals. Curr Trop Med Rep. 2020 Aug 20; 1-5. PMID: 32844081.
      Citations: 7     
    30. Diemert DJ, Freire J, Valente V, Fraga CG, Talles F, Grahek S, Campbell D, Jariwala A, Periago MV, Enk M, Gazzinelli MF, Bottazzi ME, Hamilton R, Brelsford J, Yakovleva A, Li G, Peng J, Correa-Oliveira R, Hotez P, Bethony J. Correction: Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults. PLoS Negl Trop Dis. 2020 08; 14(8):e0008670. PMID: 32804987.
      Citations:    Fields:    
    31. Hotez PJ, Bottazzi ME. Developing a low-cost and accessible COVID-19 vaccine for global health. PLoS Negl Trop Dis. 2020 07; 14(7):e0008548. PMID: 32726304.
      Citations: 12     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    32. Mekonnen GG, Tedla BA, Pickering D, Becker L, Wang L, Zhan B, Bottazzi ME, Loukas A, Sotillo J, Pearson MS. Schistosoma haematobium Extracellular Vesicle Proteins Confer Protection in a Heterologous Model of Schistosomiasis. Vaccines (Basel). 2020 Jul 24; 8(3). PMID: 32722279.
      Citations: 8     
    33. Bartsch SM, O'Shea KJ, Ferguson MC, Bottazzi ME, Wedlock PT, Strych U, McKinnell JA, Siegmund SS, Cox SN, Hotez PJ, Lee BY. Vaccine Efficacy Needed for a COVID-19 Coronavirus Vaccine to Prevent or Stop an Epidemic as the Sole Intervention. Am J Prev Med. 2020 10; 59(4):493-503. PMID: 32778354.
      Citations: 35     Fields:    Translation:HumansCellsPHPublic Health
    34. Clark E, Fredricks K, Woc-Colburn L, Bottazzi ME, Weatherhead J. Disproportionate impact of the COVID-19 pandemic on immigrant communities in the United States. PLoS Negl Trop Dis. 2020 07; 14(7):e0008484. PMID: 32658925.
      Citations: 24     Fields:    Translation:HumansCellsPHPublic Health
    35. Villanueva-Lizama LE, Cruz-Chan JV, Versteeg L, Teh-Poot CF, Hoffman K, Kendricks A, Keegan B, Pollet J, Gusovsky F, Hotez PJ, Bottazzi ME, Jones KM. TLR4 agonist protects against Trypanosoma cruzi acute lethal infection by decreasing cardiac parasite burdens. Parasite Immunol. 2020 10; 42(10):e12769. PMID: 32592180.
      Citations: 2     Fields:    Translation:Animals
    36. Hotez PJ, Corry DB, Strych U, Bottazzi ME. COVID-19 vaccines: neutralizing antibodies and the alum advantage. Nat Rev Immunol. 2020 07; 20(7):399-400. PMID: 32499636.
      Citations: 24     Fields:    Translation:HumansAnimals
    37. Bottazzi ME, Strych U, Hotez PJ, Corry DB. Coronavirus vaccine-associated lung immunopathology-what is the significance? Microbes Infect. 2020 10; 22(9):403-404. PMID: 32599077.
      Citations: 5     Fields:    Translation:HumansCellsPHPublic Health
    38. Bottazzi ME. I Never Thought I Had "Moral Courage," until COVID-19 Happened. Am J Trop Med Hyg. 2020 08; 103(2):551. PMID: 32588797.
      Citations:    Fields:    Translation:HumansCellsPHPublic Health
    39. Naceanceno KS, Matamoros G, Gabrie JA, Bottazzi ME, Sanchez A, Mejia R. Use of Multi-Parallel Real-Time Quantitative PCR to Determine Blastocystis Prevalence and Association with Other Gastrointestinal Parasite Infection in a Rural Honduran Location. Am J Trop Med Hyg. 2020 06; 102(6):1373-1375. PMID: 32189609.
      Citations: 3     Fields:    Translation:HumansAnimals
    40. Bartsch SM, O'Shea KJ, Ferguson MC, Bottazzi ME, Cox SN, Strych U, McKinnell JA, Wedlock PT, Siegmund SS, Hotez PJ, Lee BY. How Efficacious Must a COVID-19 Coronavirus Vaccine be to Prevent or Stop an Epidemic by Itself. medRxiv. 2020 May 30. PMID: 32511569.
    41. Chen WH, Tao X, Agrawal A, Algaissi A, Peng BH, Pollet J, Strych U, Bottazzi ME, Hotez PJ, Lustigman S, Du L, Jiang S, Tseng CK. Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1) Formulated with Alum Induces Protective Immunity and Reduces Immune Enhancement. bioRxiv. 2020 May 22. PMID: 32511385.
    42. Dumonteil E, Herrera C, Tu W, Goff K, Fahlberg M, Haupt E, Kaur A, Marx PA, Ortega-Lopez J, Hotez PJ, Bottazzi ME. Safety and immunogenicity of a recombinant vaccine against Trypanosoma cruzi in Rhesus macaques. Vaccine. 2020 06 15; 38(29):4584-4591. PMID: 32417142.
      Citations: 2     Fields:    Translation:AnimalsCells
    43. Hotez PJ, Corry DB, Bottazzi ME. COVID-19 vaccine design: the Janus face of immune enhancement. Nat Rev Immunol. 2020 06; 20(6):347-348. PMID: 32346094.
      Citations: 57     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    44. Marcinkiewicz AL, Lieknina I, Yang X, Lederman PL, Hart TM, Yates J, Chen WH, Bottazzi ME, Mantis NJ, Kraiczy P, Pal U, Tars K, Lin YP. The Factor H-Binding Site of CspZ as a Protective Target against Multistrain, Tick-Transmitted Lyme Disease. Infect Immun. 2020 04 20; 88(5). PMID: 32122944.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    45. Hotez PJ, Bottazzi ME, Corry DB. The potential role of Th17 immune responses in coronavirus immunopathology and vaccine-induced immune enhancement. Microbes Infect. 2020 May - Jun; 22(4-5):165-167. PMID: 32305501.
      Citations: 40     Fields:    Translation:HumansCellsPHPublic Health
    46. Chen WH, Hotez PJ, Bottazzi ME. Potential for developing a SARS-CoV receptor-binding domain (RBD) recombinant protein as a heterologous human vaccine against coronavirus infectious disease (COVID)-19. Hum Vaccin Immunother. 2020 06 02; 16(6):1239-1242. PMID: 32298218.
      Citations: 29     Fields:    Translation:HumansCellsPHPublic Health
    47. Hotez PJ, Bottazzi ME, Singh SK, Brindley PJ, Kamhawi S. Will COVID-19 become the next neglected tropical disease? PLoS Negl Trop Dis. 2020 04; 14(4):e0008271. PMID: 32275667.
      Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
    48. Hotez PJ, Damania A, Bottazzi ME. Central Latin America: Two decades of challenges in neglected tropical disease control. PLoS Negl Trop Dis. 2020 03; 14(3):e0007962. PMID: 32214311.
      Citations: 3     Fields:    Translation:HumansPHPublic Health
    49. Kendricks AL, Gray SB, Wilkerson GK, Sands CM, Abee CR, Bernacky BJ, Hotez PJ, Bottazzi ME, Craig SL, Jones KM. Reproductive Outcomes in Rhesus Macaques (Macaca mulatta) with Naturally-acquired Trypanosoma cruzi Infection. Comp Med. 2020 04 01; 70(2):152-159. PMID: 32183928.
      Citations:    Fields:    Translation:Animals
    50. Bartsch SM, Stokes-Cawley OJ, Buekens P, Asti L, Bottazzi ME, Strych U, Wedlock PT, Mitgang EA, Meymandi S, Falcon-Lezama JA, Hotez PJ, Lee BY. The potential economic value of a therapeutic Chagas disease vaccine for pregnant women to prevent congenital transmission. Vaccine. 2020 04 03; 38(16):3261-3270. PMID: 32171575.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    51. Chen WH, Strych U, Hotez PJ, Bottazzi ME. The SARS-CoV-2 Vaccine Pipeline: an Overview. Curr Trop Med Rep. 2020 Mar 03; 1-4. PMID: 32219057.
      Citations: 165     
    52. Chen WH, Nyon MP, Poongavanam MV, Liu Z, Biter AB, Kundu RT, Strych U, Hotez PJ, Bottazzi ME. Process Characterization and Biophysical Analysis for a Yeast-Expressed Phlebotomus papatasi Salivary Protein (PpSP15) as a Leishmania Vaccine Candidate. J Pharm Sci. 2020 05; 109(5):1673-1680. PMID: 32070701.
      Citations: 1     Fields:    Translation:Animals
    53. Versteeg L, Wei J, Liu Z, Keegan B, Fujiwara RT, Jones KM, Asojo O, Strych U, Bottazzi ME, Hotez PJ, Zhan B. Protective immunity elicited by the nematode-conserved As37 recombinant protein against Ascaris suum infection. PLoS Negl Trop Dis. 2020 02; 14(2):e0008057. PMID: 32053593.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    54. Bartsch SM, Asti L, Stokes-Cawley OJ, Sim SY, Bottazzi ME, Hotez PJ, Lee BY. The Potential Economic Value of a Zika Vaccine for a Woman of Childbearing Age. Am J Prev Med. 2020 03; 58(3):370-377. PMID: 31980305.
      Citations:    Fields:    Translation:HumansPHPublic Health
    55. Hoffman KA, Reynolds C, Bottazzi ME, Hotez P, Jones K. Improved Biomarker and Imaging Analysis for Characterizing Progressive Cardiac Fibrosis in a Mouse Model of Chronic Chagasic Cardiomyopathy. J Am Heart Assoc. 2019 11 19; 8(22):e013365. PMID: 31718442.
      Citations: 2     Fields:    Translation:AnimalsCells
    56. Bottazzi ME. Inspiring women scientists in Honduras. EBioMedicine. 2019 Nov; 49:21. PMID: 31636013.
      Citations: 1     Fields:    Translation:Humans
    57. Poveda C, Biter AB, Bottazzi ME, Strych U. Establishing Preferred Product Characterization for the Evaluation of RNA Vaccine Antigens. Vaccines (Basel). 2019 Sep 27; 7(4). PMID: 31569760.
      Citations: 4     
    58. Biter AB, Pollet J, Chen WH, Strych U, Hotez PJ, Bottazzi ME. A method to probe protein structure from UV absorbance spectra. Anal Biochem. 2019 12 15; 587:113450. PMID: 31550438.
      Citations:    Fields:    Translation:Cells
    59. George PJ, Hess JA, Jain S, Patton JB, Zhan T, Tricoche N, Zhan B, Bottazzi ME, Hotez PJ, Abraham D, Lustigman S. Antibody responses against the vaccine antigens Ov-103 and Ov-RAL-2 are associated with protective immunity to Onchocerca volvulus infection in both mice and humans. PLoS Negl Trop Dis. 2019 09; 13(9):e0007730. PMID: 31525197.
      Citations: 3     Fields:    Translation:AnimalsCellsPHPublic Health
    60. Keitel WA, Potter GE, Diemert D, Bethony J, El Sahly HM, Kennedy JK, Patel SM, Plieskatt JL, Jones W, Deye G, Bottazzi ME, Hotez PJ, Atmar RL. A phase 1 study of the safety, reactogenicity, and immunogenicity of a Schistosoma mansoni vaccine with or without glucopyranosyl lipid A aqueous formulation (GLA-AF) in healthy adults from a non-endemic area. Vaccine. 2019 10 08; 37(43):6500-6509. PMID: 31515141.
      Citations: 9     Fields:    Translation:HumansAnimalsCTClinical Trials
    61. Alonso-Padilla J, Cortés-Serra N, Pinazo MJ, Bottazzi ME, Abril M, Barreira F, Sosa-Estani S, Hotez PJ, Gascón J. Response to `letter to the editor: 'Strategies to enhance access to diagnosis and treatment for Chagas disease patients in Latin America'´. Expert Rev Anti Infect Ther. 2019 09; 17(9):673-675. PMID: 31361163.
      Citations:    Fields:    Translation:Humans
    62. Bottazzi ME, Hotez PJ. "Running the Gauntlet": Formidable challenges in advancing neglected tropical diseases vaccines from development through licensure, and a "Call to Action". Hum Vaccin Immunother. 2019; 15(10):2235-2242. PMID: 31180271.
      Citations: 4     Fields:    Translation:HumansPHPublic Health
    63. Barry MA, Versteeg L, Wang Q, Pollet J, Zhan B, Gusovsky F, Bottazzi ME, Hotez PJ, Jones KM. A therapeutic vaccine prototype induces protective immunity and reduces cardiac fibrosis in a mouse model of chronic Trypanosoma cruzi infection. PLoS Negl Trop Dis. 2019 05; 13(5):e0007413. PMID: 31145733.
      Citations: 13     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    64. Bartsch SM, Bottazzi ME, Asti L, Strych U, Meymandi S, Falcón-Lezama JA, Randall S, Hotez PJ, Lee BY. Economic value of a therapeutic Chagas vaccine for indeterminate and Chagasic cardiomyopathy patients. Vaccine. 2019 06 19; 37(28):3704-3714. PMID: 31104883.
      Citations: 4     Fields:    Translation:HumansAnimalsPHPublic Health
    65. Alonso-Padilla J, Cortés-Serra N, Pinazo MJ, Bottazzi ME, Abril M, Barreira F, Sosa-Estani S, Hotez PJ, Gascón J. Strategies to enhance access to diagnosis and treatment for Chagas disease patients in Latin America. Expert Rev Anti Infect Ther. 2019 03; 17(3):145-157. PMID: 30712412.
      Citations: 14     Fields:    Translation:HumansAnimals
    66. Wang L, Zou Y, Zhu X, Bottazzi ME, Hotez PJ, Zhan B. China's shifting neglected parasitic infections in an era of economic reform, urbanization, disease control, and the Belt and Road Initiative. PLoS Negl Trop Dis. 2019 01; 13(1):e0006946. PMID: 30677027.
      Citations: 4     Fields:    Translation:HumansPHPublic Health
    67. Weatherhead JE, Porter P, Coffey A, Haydel D, Versteeg L, Zhan B, Gazzinelli Guimarães AC, Fujiwara R, Jaramillo AM, Bottazzi ME, Hotez PJ, Corry DB, Beaumier CM. Ascaris Larval Infection and Lung Invasion Directly Induce Severe Allergic Airway Disease in Mice. Infect Immun. 2018 12; 86(12). PMID: 30249744.
      Citations: 8     Fields:    Translation:AnimalsCells
    68. Hotez PJ, Bottazzi ME, Bethony J, Diemert DD. Advancing the Development of a Human Schistosomiasis Vaccine. Trends Parasitol. 2019 02; 35(2):104-108. PMID: 30455112.
      Citations: 12     Fields:    Translation:Humans
    69. Gazzinelli-Guimarães AC, Gazzinelli-Guimarães PH, Nogueira DS, Oliveira FMS, Barbosa FS, Amorim CCO, Cardoso MS, Kraemer L, Caliari MV, Akamatsu MA, Ho PL, Jones KM, Weatherhead J, Bottazzi ME, Hotez PJ, Zhan B, Bartholomeu DC, Russo RC, Bueno LL, Fujiwara RT. IgG Induced by Vaccination With Ascaris suum Extracts Is Protective Against Infection. Front Immunol. 2018; 9:2535. PMID: 30473693.
      Citations: 10     Fields:    Translation:AnimalsPHPublic Health
    70. Zhan B, Arumugam S, Kennedy MW, Tricoche N, Lian LY, Asojo OA, Bennuru S, Bottazzi ME, Hotez PJ, Lustigman S, Klei TR. Ligand binding properties of two Brugia malayi fatty acid and retinol (FAR) binding proteins and their vaccine efficacies against challenge infection in gerbils. PLoS Negl Trop Dis. 2018 10; 12(10):e0006772. PMID: 30296268.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    71. Gunter SM, Versteeg L, Jones KM, Keegan BP, Strych U, Bottazzi ME, Hotez PJ, Brown EL. Covalent vaccination with Trypanosoma cruzi Tc24 induces catalytic antibody production. Parasite Immunol. 2018 Nov; 40(11):e12585. PMID: 30132929.
      Citations: 1     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    72. de la Cruz JJ, Villanueva-Lizama L, Dzul-Huchim V, Ramírez-Sierra MJ, Martinez-Vega P, Rosado-Vallado M, Ortega-Lopez J, Flores-Pucheta CI, Gillespie P, Zhan B, Bottazzi ME, Hotez PJ, Dumonteil E. Production of recombinant TSA-1 and evaluation of its potential for the immuno-therapeutic control of Trypanosoma cruzi infection in mice. Hum Vaccin Immunother. 2019; 15(1):210-219. PMID: 30192702.
      Citations: 6     Fields:    Translation:AnimalsCells
    73. Briggs N, Wei J, Versteeg L, Zhan B, Keegan B, Damania A, Pollet J, Hayes KS, Beaumier C, Seid CA, Leong J, Grencis RK, Bottazzi ME, Sastry KJ, Hotez PJ. Trichuris muris whey acidic protein induces type 2 protective immunity against whipworm. PLoS Pathog. 2018 08; 14(8):e1007273. PMID: 30153307.
      Citations: 7     Fields:    Translation:AnimalsPHPublic Health
    74. Diemert DJ, Bottazzi ME, Plieskatt J, Hotez PJ, Bethony JM. Lessons along the Critical Path: Developing Vaccines against Human Helminths. Trends Parasitol. 2018 09; 34(9):747-758. PMID: 30064902.
      Citations: 10     Fields:    Translation:Humans
    75. Jain S, George PJ, Deng W, Koussa J, Parkhouse K, Hensley SE, Jiang J, Lu J, Liu Z, Wei J, Zhan B, Bottazzi ME, Shen H, Lustigman S. The parasite-derived rOv-ASP-1 is an effective antigen-sparing CD4+ T cell-dependent adjuvant for the trivalent inactivated influenza vaccine, and functions in the absence of MyD88 pathway. Vaccine. 2018 06 14; 36(25):3650-3665. PMID: 29764680.
      Citations: 1     Fields:    Translation:AnimalsCellsPHPublic Health
    76. Diemert D, Campbell D, Brelsford J, Leasure C, Li G, Peng J, Zumer M, Younes N, Bottazzi ME, Mejia R, Pritchard DI, Hawdon JM, Bethony JM. Controlled Human Hookworm Infection: Accelerating Human Hookworm Vaccine Development. Open Forum Infect Dis. 2018 May; 5(5):ofy083. PMID: 29780848.
      Citations: 6     
    77. Jones K, Versteeg L, Damania A, Keegan B, Kendricks A, Pollet J, Cruz-Chan JV, Gusovsky F, Hotez PJ, Bottazzi ME. Vaccine-Linked Chemotherapy Improves Benznidazole Efficacy for Acute Chagas Disease. Infect Immun. 2018 04; 86(4). PMID: 29311242.
      Citations: 10     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    78. Bouchery T, Filbey K, Shepherd A, Chandler J, Patel D, Schmidt A, Camberis M, Peignier A, Smith AAT, Johnston K, Painter G, Pearson M, Giacomin P, Loukas A, Bottazzi ME, Hotez P, LeGros G. A novel blood-feeding detoxification pathway in Nippostrongylus brasiliensis L3 reveals a potential checkpoint for arresting hookworm development. PLoS Pathog. 2018 03; 14(3):e1006931. PMID: 29566094.
      Citations: 7     Fields:    Translation:AnimalsCells
    79. Nyon MP, Du L, Tseng CK, Seid CA, Pollet J, Naceanceno KS, Agrawal A, Algaissi A, Peng BH, Tai W, Jiang S, Bottazzi ME, Strych U, Hotez PJ. Engineering a stable CHO cell line for the expression of a MERS-coronavirus vaccine antigen. Vaccine. 2018 03 27; 36(14):1853-1862. PMID: 29496347.
      Citations: 26     Fields:    Translation:AnimalsCells
    80. Villanueva-Lizama LE, Cruz-Chan JV, Aguilar-Cetina ADC, Herrera-Sanchez LF, Rodriguez-Perez JM, Rosado-Vallado ME, Ramirez-Sierra MJ, Ortega-Lopez J, Jones K, Hotez P, Bottazzi ME, Dumonteil E. Trypanosoma cruzi vaccine candidate antigens Tc24 and TSA-1 recall memory immune response associated with HLA-A and -B supertypes in Chagasic chronic patients from Mexico. PLoS Negl Trop Dis. 2018 01; 12(1):e0006240. PMID: 29377898.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    81. Biter AB, Weltje S, Hudspeth EM, Seid CA, McAtee CP, Chen WH, Pollet JB, Strych U, Hotez PJ, Bottazzi ME. Characterization and Stability of Trypanosoma cruzi 24-C4 (Tc24-C4), a Candidate Antigen for a Therapeutic Vaccine Against Chagas Disease. J Pharm Sci. 2018 05; 107(5):1468-1473. PMID: 29274820.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    82. McKenna ML, McAtee S, Bryan PE, Jeun R, Ward T, Kraus J, Bottazzi ME, Hotez PJ, Flowers CC, Mejia R. Human Intestinal Parasite Burden and Poor Sanitation in Rural Alabama. Am J Trop Med Hyg. 2017 Nov; 97(5):1623-1628. PMID: 29016326.
      Citations: 21     Fields:    Translation:HumansAnimalsPHPublic Health
    83. Lustigman S, Makepeace BL, Klei TR, Babayan SA, Hotez P, Abraham D, Bottazzi ME. Onchocerca volvulus: The Road from Basic Biology to a Vaccine. Trends Parasitol. 2018 01; 34(1):64-79. PMID: 28958602.
      Citations: 10     Fields:    Translation:HumansAnimals
    84. Konduri V, Halpert MM, Liang D, Levitt JM, Cruz-Chan JV, Zhan B, Bottazzi ME, Hotez PJ, Jones KM, Decker WK. Genetic Adjuvantation of a Cell-Based Therapeutic Vaccine for Amelioration of Chagasic Cardiomyopathy. Infect Immun. 2017 09; 85(9). PMID: 28674032.
      Citations: 6     Fields:    Translation:AnimalsCells
    85. Liu Z, Kelleher A, Tabb S, Wei J, Pollet J, Hotez PJ, Bottazzi ME, Zhan B, Asojo OA. Identification, Characterization, and Structure of Tm16 from Trichuris muris. J Parasitol Res. 2017; 2017:4342789. PMID: 28884022.
      Citations: 4     
    86. Wei J, Versteeg L, Liu Z, Keegan B, Gazzinelli-Guimarães AC, Fujiwara RT, Briggs N, Jones KM, Strych U, Beaumier CM, Bottazzi ME, Hotez PJ, Zhan B. Yeast-expressed recombinant As16 protects mice against Ascaris suum infection through induction of a Th2-skewed immune response. PLoS Negl Trop Dis. 2017 Jul; 11(7):e0005769. PMID: 28708895.
      Citations: 8     Fields:    Translation:AnimalsCellsPHPublic Health
    87. Gunter SM, Jones KM, Seid CA, Essigmann HT, Zhan B, Strych U, Bottazzi ME, Hotez PJ, Brown EL. Mutations to Cysteine Residues in the Trypanosoma cruzi B-Cell Superantigen Tc24 Diminish Susceptibility to IgM-Mediated Hydrolysis. J Parasitol. 2017 10; 103(5):579-583. PMID: 28581897.
      Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    88. Diemert DJ, Freire J, Valente V, Fraga CG, Talles F, Grahek S, Campbell D, Jariwala A, Periago MV, Enk M, Gazzinelli MF, Bottazzi ME, Hamilton R, Brelsford J, Yakovleva A, Li G, Peng J, Correa-Oliveira R, Hotez P, Bethony J. Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults. PLoS Negl Trop Dis. 2017 05; 11(5):e0005574. PMID: 28464026.
      Citations: 18     Fields:    Translation:HumansAnimalsCTClinical Trials
    89. Chen WH, Chag SM, Poongavanam MV, Biter AB, Ewere EA, Rezende W, Seid CA, Hudspeth EM, Pollet J, McAtee CP, Strych U, Bottazzi ME, Hotez PJ. Optimization of the Production Process and Characterization of the Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1), a SARS Vaccine Candidate. J Pharm Sci. 2017 08; 106(8):1961-1970. PMID: 28456726.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    90. Asojo OA, Kelleher A, Liu Z, Pollet J, Hudspeth EM, Rezende WC, Groen MJ, Seid CA, Abdeladhim M, Townsend S, de Castro W, Mendes-Sousa A, Bartholomeu DC, Fujiwara RT, Bottazzi ME, Hotez PJ, Zhan B, Oliveira F, Kamhawi S, Valenzuela JG. Structure of SALO, a leishmaniasis vaccine candidate from the sand fly Lutzomyia longipalpis. PLoS Negl Trop Dis. 2017 03; 11(3):e0005374. PMID: 28278244.
      Citations: 3     Fields:    Translation:AnimalsCells
    91. Brelsford JB, Plieskatt JL, Yakovleva A, Jariwala A, Keegan BP, Peng J, Xia P, Li G, Campbell D, Periago MV, Correa-Oliveira R, Bottazzi ME, Hotez PJ, Diemert D, Bethony JM. Advances in neglected tropical disease vaccines: Developing relative potency and functional assays for the Na-GST-1/Alhydrogel hookworm vaccine. PLoS Negl Trop Dis. 2017 02; 11(2):e0005385. PMID: 28192438.
      Citations: 6     Fields:    Translation:HumansAnimals
    92. Pollet J, Versteeg L, Rezende W, Strych U, Gusovsky F, Hotez PJ, Bottazzi ME. A simple fluorescence-based assay for quantification of the Toll-Like Receptor agonist E6020 in vaccine formulations. Vaccine. 2017 03 07; 35(10):1410-1416. PMID: 28190745.
      Citations:    Fields:    Translation:Humans
    93. McAtee CP, Seid CA, Hammond M, Hudspeth E, Keegan BP, Liu Z, Wei J, Zhan B, Arjona-Sabido R, Cruz-Chan V, Dumonteil E, Hotez PJ, Bottazzi ME. Expression, purification, immunogenicity and protective efficacy of a recombinant nucleoside hydrolase from Leishmania donovani, a vaccine candidate for preventing cutaneous leishmaniasis. Protein Expr Purif. 2017 02; 130:129-136. PMID: 27773761.
      Citations: 5     Fields:    Translation:Animals
    94. Seid CA, Jones KM, Pollet J, Keegan B, Hudspeth E, Hammond M, Wei J, McAtee CP, Versteeg L, Gutierrez A, Liu Z, Zhan B, Respress JL, Strych U, Bottazzi ME, Hotez PJ. Cysteine mutagenesis improves the production without abrogating antigenicity of a recombinant protein vaccine candidate for human chagas disease. Hum Vaccin Immunother. 2017 03 04; 13(3):621-633. PMID: 27737611.
      Citations: 11     Fields:    Translation:AnimalsCells
    95. Wei J, Damania A, Gao X, Liu Z, Mejia R, Mitreva M, Strych U, Bottazzi ME, Hotez PJ, Zhan B. The hookworm Ancylostoma ceylanicum intestinal transcriptome provides a platform for selecting drug and vaccine candidates. Parasit Vectors. 2016 Sep 27; 9(1):518. PMID: 27677574.
      Citations: 9     Fields:    
    96. Bartsch SM, Hotez PJ, Asti L, Zapf KM, Bottazzi ME, Diemert DJ, Lee BY. The Global Economic and Health Burden of Human Hookworm Infection. PLoS Negl Trop Dis. 2016 09; 10(9):e0004922. PMID: 27607360.
      Citations: 38     Fields:    Translation:Humans
    97. Hess JA, Zhan B, Torigian AR, Patton JB, Petrovsky N, Zhan T, Bottazzi ME, Hotez PJ, Klei TR, Lustigman S, Abraham D. The Immunomodulatory Role of Adjuvants in Vaccines Formulated with the Recombinant Antigens Ov-103 and Ov-RAL-2 against Onchocerca volvulus in Mice. PLoS Negl Trop Dis. 2016 07; 10(7):e0004797. PMID: 27387453.
      Citations: 7     Fields:    Translation:HumansAnimalsPHPublic Health
    98. Hotez PJ, Strych U, Lustigman S, Bottazzi ME. Human anthelminthic vaccines: Rationale and challenges. Vaccine. 2016 06 24; 34(30):3549-55. PMID: 27171753.
      Citations: 18     Fields:    Translation:Humans
    99. Arumugam S, Wei J, Liu Z, Abraham D, Bell A, Bottazzi ME, Hotez PJ, Zhan B, Lustigman S, Klei TR. Vaccination of Gerbils with Bm-103 and Bm-RAL-2 Concurrently or as a Fusion Protein Confers Consistent and Improved Protection against Brugia malayi Infection. PLoS Negl Trop Dis. 2016 Apr; 10(4):e0004586. PMID: 27045170.
      Citations: 12     Fields:    Translation:Animals
    100. Hotez PJ, Beaumier CM, Gillespie PM, Strych U, Hayward T, Bottazzi ME. Advancing a vaccine to prevent hookworm disease and anemia. Vaccine. 2016 06 03; 34(26):3001-3005. PMID: 27040400.
      Citations: 11     Fields:    Translation:HumansAnimals
    101. Merrifield M, Hotez PJ, Beaumier CM, Gillespie P, Strych U, Hayward T, Bottazzi ME. Advancing a vaccine to prevent human schistosomiasis. Vaccine. 2016 06 03; 34(26):2988-2991. PMID: 27036511.
      Citations: 33     Fields:    Translation:HumansAnimals
    102. Beaumier CM, Gillespie PM, Strych U, Hayward T, Hotez PJ, Bottazzi ME. Status of vaccine research and development of vaccines for Chagas disease. Vaccine. 2016 06 03; 34(26):2996-3000. PMID: 27026146.
      Citations: 19     Fields:    Translation:Humans
    103. Bartsch SM, Hotez PJ, Hertenstein DL, Diemert DJ, Zapf KM, Bottazzi ME, Bethony JM, Brown ST, Lee BY. Modeling the economic and epidemiologic impact of hookworm vaccine and mass drug administration (MDA) in Brazil, a high transmission setting. Vaccine. 2016 Apr 27; 34(19):2197-206. PMID: 27002501.
      Citations: 10     Fields:    Translation:HumansPHPublic Health
    104. Gillespie PM, Beaumier CM, Strych U, Hayward T, Hotez PJ, Bottazzi ME. Status of vaccine research and development of vaccines for leishmaniasis. Vaccine. 2016 06 03; 34(26):2992-2995. PMID: 26973063.
      Citations: 48     Fields:    Translation:HumansAnimals
    105. Pecoul B, Batista C, Stobbaerts E, Ribeiro I, Vilasanjuan R, Gascon J, Pinazo MJ, Moriana S, Gold S, Pereiro A, Navarro M, Torrico F, Bottazzi ME, Hotez PJ. The BENEFIT Trial: Where Do We Go from Here? PLoS Negl Trop Dis. 2016 Feb; 10(2):e0004343. PMID: 26913759.
      Citations: 41     Fields:    Translation:HumansAnimals
    106. Barry MA, Wang Q, Jones KM, Heffernan MJ, Buhaya MH, Beaumier CM, Keegan BP, Zhan B, Dumonteil E, Bottazzi ME, Hotez PJ. A therapeutic nanoparticle vaccine against Trypanosoma cruzi in a BALB/c mouse model of Chagas disease. Hum Vaccin Immunother. 2016 04 02; 12(4):976-87. PMID: 26890466.
      Citations: 16     Fields:    Translation:AnimalsCells
    107. Hudspeth EM, Wang Q, Seid CA, Hammond M, Wei J, Liu Z, Zhan B, Pollet J, Heffernan MJ, McAtee CP, Engler DA, Matsunami RK, Strych U, Asojo OA, Hotez PJ, Bottazzi ME. Expression and purification of an engineered, yeast-expressed Leishmania donovani nucleoside hydrolase with immunogenic properties. Hum Vaccin Immunother. 2016 07 02; 12(7):1707-20. PMID: 26839079.
      Citations: 4     Fields:    Translation:AnimalsCells
    108. Gunter SM, Jones KM, Zhan B, Essigmann HT, Murray KO, Garcia MN, Gorchakov R, Bottazzi ME, Hotez PJ, Brown EL. Identification and Characterization of the Trypanosoma cruzi B-cell Superantigen Tc24. Am J Trop Med Hyg. 2016 Jan; 94(1):114-121. PMID: 26598565.
      Citations: 1     Fields:    Translation:HumansAnimals
    109. Zhan B, Ajmera R, Geiger SM, Gonçalves MT, Liu Z, Wei J, Wilkins PP, Fujiwara R, Gazzinelli-Guimaraes PH, Bottazzi ME, Hotez P. Identification of immunodominant antigens for the laboratory diagnosis of toxocariasis. Trop Med Int Health. 2015 Dec; 20(12):1787-96. PMID: 26426162.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    110. Hotez PJ, Bottazzi ME, Strych U. New Vaccines for the World's Poorest People. Annu Rev Med. 2016; 67:405-17. PMID: 26356803.
      Citations: 14     Fields:    Translation:Humans
    111. Martinez-Campos V, Martinez-Vega P, Ramirez-Sierra MJ, Rosado-Vallado M, Seid CA, Hudspeth EM, Wei J, Liu Z, Kwityn C, Hammond M, Ortega-López J, Zhan B, Hotez PJ, Bottazzi ME, Dumonteil E. Expression, purification, immunogenicity, and protective efficacy of a recombinant Tc24 antigen as a vaccine against Trypanosoma cruzi infection in mice. Vaccine. 2015 Aug 26; 33(36):4505-12. PMID: 26192358.
      Citations: 16     Fields:    Translation:AnimalsCells
    112. Hotez PJ, Bottazzi ME, Strych U, Chang LY, Lim YA, Goodenow MM, AbuBakar S. Neglected tropical diseases among the Association of Southeast Asian Nations (ASEAN): overview and update. PLoS Negl Trop Dis. 2015 Apr; 9(4):e0003575. PMID: 25880767.
      Citations: 28     Fields:    Translation:HumansAnimalsPHPublic Health
    113. Bottazzi ME. The human hookworm vaccine: recent updates and prospects for success. J Helminthol. 2015 Sep; 89(5):540-4. PMID: 25850789.
      Citations: 5     Fields:    Translation:HumansAnimalsPHPublic Health
    114. Hotez PJ, Bottazzi ME, Dumonteil E, Buekens P. The Gulf of Mexico: a "hot zone" for neglected tropical diseases? PLoS Negl Trop Dis. 2015 Feb; 9(2):e0003481. PMID: 25719411.
      Citations: 1     Fields:    
    115. Hotez PJ, Bottazzi ME, Zhan B, Makepeace BL, Klei TR, Abraham D, Taylor DW, Lustigman S. The Onchocerciasis Vaccine for Africa--TOVA--Initiative. PLoS Negl Trop Dis. 2015 Jan; 9(1):e0003422. PMID: 25634641.
      Citations: 12     Fields:    
    116. Pearson MS, Jariwala AR, Abbenante G, Plieskatt J, Wilson D, Bottazzi ME, Hotez PJ, Keegan B, Bethony JM, Loukas A. New tools for NTD vaccines: A case study of quality control assays for product development of the human hookworm vaccine Na-APR-1M74. Hum Vaccin Immunother. 2015; 11(5):1251-7. PMID: 26018444.
      Citations: 4     Fields:    Translation:Animals
    117. Seid CA, Curti E, Jones RM, Hudspeth E, Rezende W, Pollet J, Center L, Versteeg L, Pritchard S, Musiychuk K, Yusibov V, Hotez PJ, Bottazzi ME. Expression, purification, and characterization of the Necator americanus aspartic protease-1 (Na-APR-1 (M74)) antigen, a component of the bivalent human hookworm vaccine. Hum Vaccin Immunother. 2015; 11(6):1474-88. PMID: 25905574.
      Citations: 7     Fields:    Translation:Animals
    118. Knight JM, Zingales B, Bottazzi ME, Hotez P, Zhan B. Limited antigenic variation in the Trypanosoma cruzi candidate vaccine antigen TSA-1. Parasite Immunol. 2014 Dec; 36(12):708-12. PMID: 25040249.
      Citations: 2     Fields:    Translation:HumansAnimals
    119. Garcia MN, Murray KO, Hotez PJ, Rossmann SN, Gorchakov R, Ontiveros A, Woc-Colburn L, Bottazzi ME, Rhodes CE, Ballantyne CM, Aguilar D. Development of chagas cardiac manifestations among Texas blood donors. Am J Cardiol. 2015 Jan 01; 115(1):113-7. PMID: 25456877.
      Citations: 11     Fields:    Translation:Humans
    120. Garcia MN, Woc-Colburn L, Rossmann SN, Townsend RL, Stramer SL, Bravo M, Kamel H, Beddard R, Townsend M, Oldham R, Bottazzi ME, Hotez PJ, Murray KO. Trypanosoma cruzi screening in Texas blood donors, 2008-2012. Epidemiol Infect. 2016 Apr; 144(5):1010-3. PMID: 25170765.
      Citations: 11     Fields:    Translation:HumansAnimalsPHPublic Health
    121. Lee RM, Moore LB, Bottazzi ME, Hotez PJ. Toxocariasis in North America: a systematic review. PLoS Negl Trop Dis. 2014 Aug; 8(8):e3116. PMID: 25166906.
      Citations: 29     Fields:    Translation:Humans
    122. Hotez PJ, Bottazzi ME, Tseng CT, Zhan B, Lustigman S, Du L, Jiang S. Calling for rapid development of a safe and effective MERS vaccine. Microbes Infect. 2014 Jul; 16(7):529-31. PMID: 24931059.
      Citations: 16     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    123. Hess JA, Zhan B, Bonne-Année S, Deckman JM, Bottazzi ME, Hotez PJ, Klei TR, Lustigman S, Abraham D. Vaccines to combat river blindness: expression, selection and formulation of vaccines against infection with Onchocerca volvulus in a mouse model. Int J Parasitol. 2014 Aug; 44(9):637-46. PMID: 24907553.
      Citations: 14     Fields:    Translation:Animals
    124. Hotez PJ, Woc-Colburn L, Bottazzi ME. Neglected tropical diseases in Central America and Panama: review of their prevalence, populations at risk and impact on regional development. Int J Parasitol. 2014 Aug; 44(9):597-603. PMID: 24846528.
      Citations: 21     Fields:    Translation:Humans
    125. Sanchez AL, Gabrie JA, Rueda MM, Mejia RE, Bottazzi ME, Canales M. A scoping review and prevalence analysis of soil-transmitted helminth infections in Honduras. PLoS Negl Trop Dis. 2014; 8(1):e2653. PMID: 24466359.
      Citations: 7     Fields:    Translation:HumansAnimals
    126. Zhan B, Beaumier CM, Briggs N, Jones KM, Keegan BP, Bottazzi ME, Hotez PJ. Advancing a multivalent 'Pan-anthelmintic' vaccine against soil-transmitted nematode infections. Expert Rev Vaccines. 2014 Mar; 13(3):321-31. PMID: 24392641.
      Citations: 21     Fields:    Translation:HumansAnimals
    127. Bottazzi ME. Vaccines against neglected tropical diseases: promising interventions to rescue the poorest populations in the Americas. Immunotherapy. 2014; 6(2):117-9. PMID: 24491084.
      Citations: 2     Fields:    Translation:PHPublic Health
    128. Bottazzi M, Murray KO, Hotez PJ. . Los Estados Unidos de America: Pais endemico o no endemico de la enfermedad de Chagas. Revista española de salud pública. 2014; 1(88).
    129. Bottazzi M, Mejia R. . Current tropical medicine reports: A path forward to highlight research and clinical advances, new trends and innovations. Current Tropical Medicine Reports. 2014; (1):1.
    130. Curti E, Seid CA, Hudspeth E, Center L, Rezende W, Pollet J, Kwityn C, Hammond M, Matsunami RK, Engler DA, Hotez PJ, Elena Bottazzi M. Optimization and revision of the production process of the Necator americanus glutathione S-transferase 1 (Na-GST-1), the lead hookworm vaccine recombinant protein candidate. Hum Vaccin Immunother. 2014; 10(7):1914-25. PMID: 25424799.
      Citations: 10     Fields:    Translation:HumansAnimals
    131. Chen WH, Du L, Chag SM, Ma C, Tricoche N, Tao X, Seid CA, Hudspeth EM, Lustigman S, Tseng CT, Bottazzi ME, Hotez PJ, Zhan B, Jiang S. Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate. Hum Vaccin Immunother. 2014; 10(3):648-58. PMID: 24355931.
      Citations: 43     Fields:    Translation:AnimalsCells
    132. Hotez PJ, Dumonteil E, Betancourt Cravioto M, Bottazzi ME, Tapia-Conyer R, Meymandi S, Karunakara U, Ribeiro I, Cohen RM, Pecoul B. An unfolding tragedy of Chagas disease in North America. PLoS Negl Trop Dis. 2013; 7(10):e2300. PMID: 24205411.
      Citations: 41     Fields:    Translation:HumansAnimals
    133. Sanchez AL, Canales M, Enriquez L, Bottazzi ME, Zelaya AA, Espinoza VE, Fontecha GA. A research capacity strengthening project for infectious diseases in Honduras: experience and lessons learned. Glob Health Action. 2013 Aug 07; 6:21643. PMID: 23930937.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    134. Curti E, Kwityn C, Zhan B, Gillespie P, Brelsford J, Deumic V, Plieskatt J, Rezende WC, Tsao E, Kalampanayil B, Hotez PJ, Bottazzi ME. Expression at a 20L scale and purification of the extracellular domain of the Schistosoma mansoni TSP-2 recombinant protein: a vaccine candidate for human intestinal schistosomiasis. Hum Vaccin Immunother. 2013 Nov; 9(11):2342-50. PMID: 23899507.
      Citations: 11     Fields:    Translation:Animals
    135. Cheng W, Curti E, Rezende WC, Kwityn C, Zhan B, Gillespie P, Plieskatt J, Joshi SB, Volkin DB, Hotez PJ, Middaugh CR, Bottazzi ME. Biophysical and formulation studies of the Schistosoma mansoni TSP-2 extracellular domain recombinant protein, a lead vaccine candidate antigen for intestinal schistosomiasis. Hum Vaccin Immunother. 2013 Nov; 9(11):2351-61. PMID: 23880663.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    136. Andrus J, Bottazzi ME, Chow J, Goraleski KA, Fisher-Hoch SP, Lambuth JK, Lee BY, Margolis HS, McCormick JB, Melby P, Murray KO, Rico-Hesse R, Valenzuela JG, Hotez PJ. Ears of the Armadillo: Global Health Research and Neglected Diseases in Texas. PLoS Negl Trop Dis. 2013 Jun; 7(6):e2021. PMID: 23826397.
      Citations: 9     Fields:    
    137. Hotez PJ, Diemert D, Bacon KM, Beaumier C, Bethony JM, Bottazzi ME, Brooker S, Couto AR, Freire Mda S, Homma A, Lee BY, Loukas A, Loblack M, Morel CM, Oliveira RC, Russell PK. The Human Hookworm Vaccine. Vaccine. 2013 Apr 18; 31 Suppl 2:B227-32. PMID: 23598487.
      Citations: 35     Fields:    Translation:HumansAnimals
    138. Beaumier CM, Gillespie PM, Hotez PJ, Bottazzi ME. New vaccines for neglected parasitic diseases and dengue. Transl Res. 2013 Sep; 162(3):144-55. PMID: 23578479.
      Citations: 51     Fields:    Translation:Humans
    139. Lee BY, Bacon KM, Bottazzi ME, Hotez PJ. Global economic burden of Chagas disease: a computational simulation model. Lancet Infect Dis. 2013 Apr; 13(4):342-8. PMID: 23395248.
      Citations: 166     Fields:    Translation:Humans
    140. Hotez PJ, Dumonteil E, Heffernan MJ, Bottazzi ME. Innovation for the 'bottom 100 million': eliminating neglected tropical diseases in the Americas. Adv Exp Med Biol. 2013; 764:1-12. PMID: 23654053.
      Citations: 15     Fields:    Translation:HumansPHPublic Health
    141. Jiang S, Bottazzi ME, Du L, Lustigman S, Tseng CT, Curti E, Jones K, Zhan B, Hotez PJ. Roadmap to developing a recombinant coronavirus S protein receptor-binding domain vaccine for severe acute respiratory syndrome. Expert Rev Vaccines. 2012 Dec; 11(12):1405-13. PMID: 23252385.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    142. Bacon KM, Hotez PJ, Kruchten SD, Kamhawi S, Bottazzi ME, Valenzuela JG, Lee BY. The potential economic value of a cutaneous leishmaniasis vaccine in seven endemic countries in the Americas. Vaccine. 2013 Jan 07; 31(3):480-6. PMID: 23176979.
      Citations: 19     Fields:    Translation:HumansPHPublic Health
    143. Dumonteil E, Bottazzi ME, Zhan B, Heffernan MJ, Jones K, Valenzuela JG, Kamhawi S, Ortega J, de Leon Rosales SP, Lee BY, Bacon KM, Fleischer B, Slingsby BT, Cravioto MB, Tapia-Conyer R, Hotez PJ. Accelerating the development of a therapeutic vaccine for human Chagas disease: rationale and prospects. Expert Rev Vaccines. 2012 Sep; 11(9):1043-55. PMID: 23151163.
      Citations: 37     Fields:    Translation:HumansAnimalsPHPublic Health
    144. Lee BY, Bacon KM, Wateska AR, Bottazzi ME, Dumonteil E, Hotez PJ. Modeling the economic value of a Chagas' disease therapeutic vaccine. Hum Vaccin Immunother. 2012 Sep; 8(9):1293-301. PMID: 22894964.
      Citations: 24     Fields:    Translation:Humans
    145. Zhan B, Santiago H, Keegan B, Gillespie P, Xue J, Bethony J, de Oliveira LM, Jiang D, Diemert D, Xiao SH, Jones K, Feng X, Hotez PJ, Bottazzi ME. Fusion of Na-ASP-2 with human immunoglobulin Fc? abrogates histamine release from basophils sensitized with anti-Na-ASP-2 IgE. Parasite Immunol. 2012 Aug-Sep; 34(8-9):404-11. PMID: 22651670.
      Citations: 7     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    146. Hotez PJ, Dumonteil E, Woc-Colburn L, Serpa JA, Bezek S, Edwards MS, Hallmark CJ, Musselwhite LW, Flink BJ, Bottazzi ME. Chagas disease: "the new HIV/AIDS of the Americas". PLoS Negl Trop Dis. 2012; 6(5):e1498. PMID: 22666504.
      Citations: 68     Fields:    Translation:HumansPHPublic Health
    147. Plieskatt JL, Rezende WC, Olsen CM, Trefethen JM, Joshi SB, Middaugh CR, Hotez PJ, Bottazzi ME. Advances in vaccines against neglected tropical diseases: enhancing physical stability of a recombinant hookworm vaccine through biophysical and formulation studies. Hum Vaccin Immunother. 2012 Jun; 8(6):765-76. PMID: 22495115.
      Citations: 8     Fields:    Translation:HumansAnimals
    148. Goud GN, Deumic V, Gupta R, Brelsford J, Zhan B, Gillespie P, Plieskatt JL, Tsao EI, Hotez PJ, Bottazzi ME. Expression, purification, and molecular analysis of the Necator americanus glutathione S-transferase 1 (Na-GST-1): a production process developed for a lead candidate recombinant hookworm vaccine antigen. Protein Expr Purif. 2012 Jun; 83(2):145-51. PMID: 22503665.
      Citations: 12     Fields:    Translation:Animals
    149. Hotez PJ, Bottazzi ME, Dumonteil E, Valenzuela JG, Kamhawi S, Ortega J, Rosales SP, Cravioto MB, Tapia-Conyer R. Texas and Mexico: sharing a legacy of poverty and neglected tropical diseases. PLoS Negl Trop Dis. 2012; 6(3):e1497. PMID: 22479656.
      Citations: 18     Fields:    Translation:HumansPHPublic Health
    150. Mathias DK, Plieskatt JL, Armistead JS, Bethony JM, Abdul-Majid KB, McMillan A, Angov E, Aryee MJ, Zhan B, Gillespie P, Keegan B, Jariwala AR, Rezende W, Bottazzi ME, Scorpio DG, Hotez PJ, Dinglasan RR. Expression, immunogenicity, histopathology, and potency of a mosquito-based malaria transmission-blocking recombinant vaccine. Infect Immun. 2012 Apr; 80(4):1606-14. PMID: 22311924.
      Citations: 22     Fields:    Translation:HumansAnimals
    151. Lustigman S, McKerrow JH, Bottazzi M. . Parasitic Helminths. 1st Edition ed. Caffrey CR, editor. Weinheim, Germany: Wiley-Blackwell. Chapter 22, Vaccines Linked to Chemotherapy: A new approach to control helminth infections. 2012; 357.
    152. Bottazzi M, Della Torre L. [Immigration, work and health--social, cultural and best practices in occupational medicine: the views of union patronage]. G Ital Med Lav Ergon. 2011 Apr-Jun; 33(2 Suppl):29-32. PMID: 22187920.
      Citations:    Fields:    Translation:Humans
    153. Jiang D, Zhan B, Mayor RS, Gillespie P, Keegan B, Bottazzi ME, Hotez P. Ac-AP-12, a novel factor Xa anticoagulant peptide from the esophageal glands of adult Ancylostoma caninum. Mol Biochem Parasitol. 2011 May; 177(1):42-8. PMID: 21251931.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    154. Bottazzi M, Dumonteil E, Valenzuela J, Betancourt-Cravioto M, Tapia-Conyer R, et al. . Bridging the innovation gap for neglected tropical diseases in Mexico: Capacity building for the development of a new generation of antipoverty vaccines. B. oletin Medico del Hospital Infantil de Mexico. 2011; (2):130.
    155. Bonafé N, Zhan B, Bottazzi ME, Perez OA, Koski RA, Asojo OA. Expression, purification, crystallization and preliminary X-ray analysis of a truncated soluble domain of human glioma pathogenesis-related protein 1. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 01; 66(Pt 11):1487-9. PMID: 21045302.
      Citations: 2     Fields:    Translation:HumansCells
    156. Jariwala AR, Oliveira LM, Diemert DJ, Keegan B, Plieskatt JL, Periago MV, Bottazzi ME, Hotez PJ, Bethony JM. Potency testing for the experimental Na-GST-1 hookworm vaccine. Expert Rev Vaccines. 2010 Oct; 9(10):1219-30. PMID: 20923271.
      Citations: 10     Fields:    Translation:HumansAnimals
    157. Zhan B, Perally S, Brophy PM, Xue J, Goud G, Liu S, Deumic V, de Oliveira LM, Bethony J, Bottazzi ME, Jiang D, Gillespie P, Xiao SH, Gupta R, Loukas A, Ranjit N, Lustigman S, Oksov Y, Hotez P. Molecular cloning, biochemical characterization, and partial protective immunity of the heme-binding glutathione S-transferases from the human hookworm Necator americanus. Infect Immun. 2010 Apr; 78(4):1552-63. PMID: 20145100.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    158. Bethony JM, Bottazzi M, Brown A, Diemert D, Loukas A, et al. . New Generation Vaccines. 4th ed. Levine MM, editor. New York: Informa Helathcare USA. Chapter 75, Hookworm Vaccines. 2010; 830.
    159. Cai S, He F, Samra HS, de la Maza LM, Bottazzi ME, Joshi SB, Middaugh CR. Biophysical and stabilization studies of the Chlamydia trachomatis mouse pneumonitis major outer membrane protein. Mol Pharm. 2009 Sep-Oct; 6(5):1553-61. PMID: 19650664.
      Citations: 7     Fields:    Translation:AnimalsCells
    160. Franco-Paredes C, Bottazzi ME, Hotez PJ. The unfinished public health agenda of chagas disease in the era of globalization. PLoS Negl Trop Dis. 2009 Jul 07; 3(7):e470. PMID: 19582139.
      Citations: 6     Fields:    Translation:HumansPHPublic Health
    161. Pearson MS, Bethony JM, Pickering DA, de Oliveira LM, Jariwala A, Santiago H, Miles AP, Zhan B, Jiang D, Ranjit N, Mulvenna J, Tribolet L, Plieskatt J, Smith T, Bottazzi ME, Jones K, Keegan B, Hotez PJ, Loukas A. An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection. FASEB J. 2009 Sep; 23(9):3007-19. PMID: 19380510.
      Citations: 25     Fields:    Translation:HumansAnimalsPHPublic Health
    162. Bottazzi ME, Brown AS. Model for product development of vaccines against neglected tropical diseases: a vaccine against human hookworm. Expert Rev Vaccines. 2008 Dec; 7(10):1481-92. PMID: 19053205.
      Citations: 3     Fields:    Translation:HumansAnimals
    163. Hotez PJ, Bottazzi ME, Franco-Paredes C, Ault SK, Periago MR. The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and elimination. PLoS Negl Trop Dis. 2008 Sep 24; 2(9):e300. PMID: 18820747.
      Citations: 221     Fields:    Translation:Humans
    164. Campi-Azevedo AC, Gazzinelli G, Bottazzi ME, Teixeira-Carvalho A, Corrêa-Oliveira R, Caldas IR. In vitro cultured peripheral blood mononuclear cells from patients with chronic schistosomiasis mansoni show immunomodulation of cyclin D1,2,3 in the presence of soluble egg antigens. Microbes Infect. 2007 Oct; 9(12-13):1493-9. PMID: 17913547.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    165. Kehn K, Berro R, Alhaj A, Bottazzi ME, Yeh WI, Klase Z, Van Duyne R, Fu S, Kashanchi F. Functional consequences of cyclin D1/BRCA1 interaction in breast cancer cells. Oncogene. 2007 Aug 02; 26(35):5060-9. PMID: 17334399.
      Citations: 16     Fields:    Translation:HumansCells
    166. Fujiwara RT, Zhan B, Mendez S, Loukas A, Bueno LL, Wang Y, Plieskatt J, Oksov Y, Lustigman S, Bottazzi ME, Hotez P, Bethony JM. Reduction of worm fecundity and canine host blood loss mediates protection against hookworm infection elicited by vaccination with recombinant Ac-16. Clin Vaccine Immunol. 2007 Mar; 14(3):281-7. PMID: 17267592.
      Citations: 11     Fields:    Translation:AnimalsCellsPHPublic Health
    167. Hotez PJ, Bethony J, Bottazzi ME, Brooker S, Diemert D, Loukas A. New technologies for the control of human hookworm infection. Trends Parasitol. 2006 Jul; 22(7):327-31. PMID: 16709466.
      Citations: 24     Fields:    Translation:HumansAnimals
    168. Bottazzi ME, Miles AP, Diemert D, Hotez PJ. An ounce of prevention on a budget: a nonprofit approach to developing vaccines against neglected diseases. Expert Rev Vaccines. 2006 Apr; 5(2):189-98. PMID: 16608419.
      Citations: 6     Fields:    Translation:Humans
    169. Williamson AL, Lustigman S, Oksov Y, Deumic V, Plieskatt J, Mendez S, Zhan B, Bottazzi ME, Hotez PJ, Loukas A. Ancylostoma caninum MTP-1, an astacin-like metalloprotease secreted by infective hookworm larvae, is involved in tissue migration. Infect Immun. 2006 Feb; 74(2):961-7. PMID: 16428741.
      Citations: 36     Fields:    Translation:Animals
    170. Ghosh K, Wu W, Antoine AD, Bottazzi ME, Valenzuela JG, Hotez PJ, Mendez S. The impact of concurrent and treated Ancylostoma ceylanicum hookworm infections on the immunogenicity of a recombinant hookworm vaccine in hamsters. J Infect Dis. 2006 Jan 01; 193(1):155-62. PMID: 16323144.
      Citations: 12     Fields:    Translation:HumansAnimalsPHPublic Health
    171. Loukas A, Bethony JM, Mendez S, Fujiwara RT, Goud GN, Ranjit N, Zhan B, Jones K, Bottazzi ME, Hotez PJ. Vaccination with recombinant aspartic hemoglobinase reduces parasite load and blood loss after hookworm infection in dogs. PLoS Med. 2005 Oct; 2(10):e295. PMID: 16231975.
      Citations: 36     Fields:    Translation:AnimalsCellsPHPublic HealthCTClinical Trials
    172. Goud GN, Bottazzi ME, Zhan B, Mendez S, Deumic V, Plieskatt J, Liu S, Wang Y, Bueno L, Fujiwara R, Samuel A, Ahn SY, Solanki M, Asojo OA, Wang J, Bethony JM, Loukas A, Roy M, Hotez PJ. Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trials. Vaccine. 2005 Sep 15; 23(39):4754-64. PMID: 16054275.
      Citations: 29     Fields:    Translation:HumansAnimalsPHPublic Health
    173. Fujiwara RT, Loukas A, Mendez S, Williamson AL, Bueno LL, Wang Y, Samuel A, Zhan B, Bottazzi ME, Hotez PJ, Bethony JM. Vaccination with irradiated Ancylostoma caninum third stage larvae induces a Th2 protective response in dogs. Vaccine. 2006 Jan 23; 24(4):501-9. PMID: 16140437.
      Citations: 16     Fields:    Translation:AnimalsCellsPHPublic Health
    174. Bethony J, Loukas A, Smout M, Brooker S, Mendez S, Plieskatt J, Goud G, Bottazzi ME, Zhan B, Wang Y, Williamson A, Lustigman S, Correa-Oliveira R, Xiao S, Hotez PJ. Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals. FASEB J. 2005 Oct; 19(12):1743-5. PMID: 16037096.
      Citations: 57     Fields:    Translation:HumansAnimals
    175. Fujiwara RT, Bethony J, Bueno LL, Wang Y, Ahn SY, Samuel A, Bottazzi ME, Hotez P, Mendez S. Immunogenicity of the hookworm Na-ASP-2 vaccine candidate: characterization of humoral and cellular responses after vaccination in the Sprague Dawley rat. Hum Vaccin. 2005 May-Jun; 1(3):123-8. PMID: 17012856.
      Citations: 6     Fields:    Translation:AnimalsCells
    176. Hotez PJ, Bethony J, Bottazzi ME, Brooker S, Buss P. Hookworm: "the great infection of mankind". PLoS Med. 2005 Mar; 2(3):e67. PMID: 15783256.
      Citations: 50     Fields:    Translation:HumansPHPublic Health
    177. Kehn K, Fuente Cde L, Strouss K, Berro R, Jiang H, Brady J, Mahieux R, Pumfery A, Bottazzi ME, Kashanchi F. The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation. Oncogene. 2005 Jan 20; 24(4):525-40. PMID: 15580311.
      Citations: 48     Fields:    Translation:HumansCells
    178. Hotez PJ, Arora S, Bethony J, Bottazzi ME, Loukas A, Correa-Oliveira R, Brooker S. Helminth infections of children: prospects for control. Adv Exp Med Biol. 2005; 568:135-44. PMID: 16108129.
      Citations: 2     Fields:    Translation:HumansAnimals
    179. Kehn K, Berro R, de la Fuente C, Strouss K, Ghedin E, Dadgar S, Bottazzi ME, Pumfery A, Kashanchi F. Mechanisms of HTLV-1 transformation. Front Biosci. 2004 Sep 01; 9:2347-72. PMID: 15353292.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    180. Seelamgari A, Maddukuri A, Berro R, de la Fuente C, Kehn K, Deng L, Dadgar S, Bottazzi ME, Ghedin E, Pumfery A, Kashanchi F. Role of viral regulatory and accessory proteins in HIV-1 replication. Front Biosci. 2004 Sep 01; 9:2388-413. PMID: 15353294.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    181. Hotez PJ, Brooker S, Bethony JM, Bottazzi ME, Loukas A, Xiao S. Hookworm infection. N Engl J Med. 2004 Aug 19; 351(8):799-807. PMID: 15317893.
      Citations: 177     Fields:    Translation:HumansAnimals
    182. Loukas A, Bethony JM, Williamson AL, Goud GN, Mendez S, Zhan B, Hawdon JM, Elena Bottazzi M, Brindley PJ, Hotez PJ. Vaccination of dogs with a recombinant cysteine protease from the intestine of canine hookworms diminishes the fecundity and growth of worms. J Infect Dis. 2004 May 15; 189(10):1952-61. PMID: 15122534.
      Citations: 28     Fields:    Translation:AnimalsPHPublic Health
    183. Kehn K, Deng L, de la Fuente C, Strouss K, Wu K, Maddukuri A, Baylor S, Rufner R, Pumfery A, Bottazzi ME, Kashanchi F. The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells. Retrovirology. 2004 Apr 13; 1:6. PMID: 15169570.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    184. Wu K, Bottazzi ME, de la Fuente C, Deng L, Gitlin SD, Maddukuri A, Dadgar S, Li H, Vertes A, Pumfery A, Kashanchi F. Protein profile of tax-associated complexes. J Biol Chem. 2004 Jan 02; 279(1):495-508. PMID: 14530271.
      Citations: 46     Fields:    Translation:HumansCells
    185. Hotez PJ, Zhan B, Bethony JM, Loukas A, Williamson A, Goud GN, Hawdon JM, Dobardzic A, Dobardzic R, Ghosh K, Bottazzi ME, Mendez S, Zook B, Wang Y, Liu S, Essiet-Gibson I, Chung-Debose S, Xiao S, Knox D, Meagher M, Inan M, Correa-Oliveira R, Vilk P, Shepherd HR, Brandt W, Russell PK. Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine Initiative. Int J Parasitol. 2003 Sep 30; 33(11):1245-58. PMID: 13678639.
      Citations: 39     Fields:    Translation:HumansAnimals
    186. Bottazzi ME, Buzzai M, Zhu X, Desdouets C, Bréchot C, Assoian RK. Distinct effects of mitogens and the actin cytoskeleton on CREB and pocket protein phosphorylation control the extent and timing of cyclin A promoter activity. Mol Cell Biol. 2001 Nov; 21(22):7607-16. PMID: 11604497.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    187. Roovers K, Davey G, Zhu X, Bottazzi ME, Assoian RK. Alpha5beta1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells. Mol Biol Cell. 1999 Oct; 10(10):3197-204. PMID: 10512860.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    188. Bottazzi ME, Zhu X, Böhmer RM, Assoian RK. Regulation of p21(cip1) expression by growth factors and the extracellular matrix reveals a role for transient ERK activity in G1 phase. J Cell Biol. 1999 Sep 20; 146(6):1255-64. PMID: 10491389.
      Citations: 33     Fields:    Translation:AnimalsCells
    189. Bottazzi ME, Assoian RK. The extracellular matrix and mitogenic growth factors control G1 phase cyclins and cyclin-dependent kinase inhibitors. Trends Cell Biol. 1997 Sep; 7(9):348-52. PMID: 17708979.
      Citations: 13     Fields:    
    190. Bottazzi, ME, Desdouets C, Brechot C, Assoian RK. . Regulation of Cyclin: A gene transcription by the extracellular matrix. 1997; 118.
    191. Assoian RK, Zhu X, Davey GE, Bottazzi ME. . Role of extracellular matrix and cytoskeleton in the regulation of cyclins, cyclin-dependent kinase inhibitors and anchorage-dependent growth. Advances in Molecular and Cell Biology. 1996; (24):57.
    192. Ambrose MR, Bottazzi ME, Goodenow MM. Expression of the c-ski proto-oncogene during cell cycle arrest and myogenic differentiation. DNA Cell Biol. 1995 Aug; 14(8):701-7. PMID: 7646817.
      Citations: 3     Fields:    Translation:AnimalsCells
    193. Bottazzi ME, Goodenow MM, Moscovici MG, Moscovici C. BM2L is a spontaneous leukemogenic variant of a non-leukemogenic v-myb-transformed myeloid cell line. Oncogene. 1993 Mar; 8(3):731-6. PMID: 8437856.
      Citations:    Fields:    Translation:AnimalsCells
    194. Bottazzi, ME, Moscovici MG, Moscovici C, Goodenow MM. . Subcellular localization of v-myb in non-leukemogenic and leukemogenic transformed cells. 1993; 521.
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