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LI ZHANG

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
DivisionMedicine-Endocrinology
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    Collapse ORNG Applications 
    Collapse Websites
    Collapse Verify Publications

    Collapse Biography 
    Collapse education and training
    University of Colorado, AuroraPostdoc fellowship05/2011Type 1 Diabetes
    University of Shandong, ChinaPh.D06/2005Endocrinology

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    ADA 7-06-MN-17     (George Eisenbarth)Jul 1, 2006 - Jun 30, 2010
    The America Diabetes Association
    Pathogenesis type 1 diabetes
    Role: Co-Investigator/Fellow

    JDRF Fellowship Award 3-2008-107     Mar 1, 2007 - Feb 28, 2010
    The Juvenile Diabetes Research Foundation International
    Insulin reactive T cell receptor repertoire
    Role: Principal Investigator

    UA19AI050864 Sub award     (LI ZHANG)Sep 1, 2010 - Aug 31, 2011
    National Institutes of Health (NIH) under Autoimmune Prevention Cooperative Study (UA19AI050864, Eisenbarth as PI)
    Vaccination” with MHC covalently tethered/register fixed primary peptide for prevention of spontaneous autoimmunity
    Role: Principal Investigator

    NAAF:2570449     (LI ZHANG)Oct 1, 2010 - Sep 30, 2011
    National Alopecia Areata Fundation
    Developing Molecular Assays for Alopecia Areata
    Role: Principal Investigator

    10-2011-138     (LI ZHANG)Mar 1, 2011 - Feb 28, 2014
    The Juvenile Diabetes Research Foundation International
    Monoclonal Antibody targeting MHC Tethered/Register-Fixed Primary Peptide.
    Role: Principal Investigator

    ADA 7-11-BS-107     (Willi Born)Jul 1, 2011 - Jun 30, 2014
    The America Diabetes Association
    The role of gamma/delta T cells in type 1 diabetes
    Role: Co-Investigator

    The Helmsley Trust Pilot Study     (Peter Gottlieb)Jul 1, 2014 - Jun 30, 2015
    The Leona M. and Harry B. Helmsley Charitable Trust
    MAS-1, A Novel Adjuvant for Antigen Specific Therapy
    Role: Co-Investigator

    JDRF1-INO-2015-74-S-B     (LI ZHANG)Jun 1, 2015 - Nov 30, 2017
    The Juvenile Diabetes Research Foundation International.
    Using insulin B:9-23 register 3 specific CAR T cells to modulate T1D
    Role: Principal Investigator

    Junior Faculty Seed Award     (LI ZHANG)Jul 1, 2015 - Jun 30, 2017
    Caroline Wiess Law Fund for Research in Molecular Medicine
    The Role of A Monoclonal Antibody Targeting A Key Autoantigen In Modulating Type 1 Diabetes.
    Role: Principal Investigator

    JDRF 2-SRA-2016-238-S-B     (LI ZHANG)Jul 1, 2016 - Jun 30, 2018
    The Juvenile Diabetes Research Foundation International.
    Mechanism study of using an antigen specific monoclonal antibody to treat type 1 diabetes.
    Role: Principal Investigator

    Diabetes grant award     (LI ZHANG)Jan 1, 2017 - Jan 31, 2017
    Diabetes Education and Action Foundation
    Using an antigen specific monoclonal antibody to modulate islet autoimmunity
    Role: Principal Investigator

    2 R01 DK112311-15A1     (Massimo Pietropaolo)Jul 1, 2017 - Jun 30, 2022
    NIH
    Enhancement of Biomarkers for Type 1 Diabetes
    Role: Co-Investigator

    Diabetes Action 2018     (LI ZHANG)Jan 1, 2018 - Jun 30, 2020
    Diabetes Education and Action
    Using an antigen specific monoclonal antibody to modulate islet autoimmunity
    Role: Principal Investigator

    2-SRA-2018-648-S-B     (LI ZHANG)Jun 1, 2018 - May 31, 2020
    The Juvenile Diabetes Research Foundation International
    To Reprogram Type 1 Diabetes Using Insulin Pathogenic Register-Specific Chimeric Antigen Receptor Redirected Regulatory T Cells
    Role: Principal Investigator

    R03AI139811     (ZHANG, LI)Jul 1, 2019 - Jun 30, 2021
    NIH
    Using Insulin Pathogenic Register Specific Chimeric Antigen Receptor Redirected Regulatory T Cells to Modulate Type 1 Diabetes
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Davidson HW, Cepeda JR, Sekhar NS, Han J, Gao L, Sosinowski T, Zhang L. High-Efficiency Generation of Antigen-Specific Primary Mouse Cytotoxic T Cells for Functional Testing in an Autoimmune Diabetes Model. J Vis Exp. 2019 08 16; (150). PMID: 31475985.
      View in: PubMed
    2. Zhang L, Sosinowski T, Cox AR, Cepeda JR, Sekhar NS, Hartig SM, Miao D, Yu L, Pietropaolo M, Davidson HW. Chimeric antigen receptor (CAR) T cells targeting a pathogenic MHC class II:peptide complex modulate the progression of autoimmune diabetes. J Autoimmun. 2019 01; 96:50-58. PMID: 30122420.
      View in: PubMed
    3. Zaidi G, Bhatia V, Sahoo SK, Sarangi AN, Bharti N, Zhang L, Yu L, Eriksson D, Bensing S, Kämpe O, Bharani N, Yachha SK, Bhansali A, Sachan A, Jain V, Shah N, Aggarwal R, Aggarwal A, Srinivasan M, Agarwal S, Bhatia E. Autoimmune polyendocrine syndrome type 1 in an Indian cohort: a longitudinal study. Endocr Connect. 2017 Jul; 6(5):289-296. PMID: 28446514.
      View in: PubMed
    4. Michels A, Zhang L, Khadra A, Kushner JA, Redondo MJ, Pietropaolo M. Prediction and prevention of type 1 diabetes: update on success of prediction and struggles at prevention. Pediatr Diabetes. 2015 Nov; 16(7):465-84. PMID: 26202050.
      View in: PubMed
    5. Miao D, Steck AK, Zhang L, Guyer KM, Jiang L, Armstrong T, Muller SM, Krischer J, Rewers M, Yu L. Electrochemiluminescence assays for insulin and glutamic acid decarboxylase autoantibodies improve prediction of type 1 diabetes risk. Diabetes Technol Ther. 2015 Feb; 17(2):119-27. PMID: 25562486.
      View in: PubMed
    6. Aydintug MK, Zhang L, Wang C, Liang D, Wands JM, Michels AW, Hirsch B, Day BJ, Zhang G, Sun D, Eisenbarth GS, O'Brien RL, Born WK. ?d T cells recognize the insulin B:9-23 peptide antigen when it is dimerized through thiol oxidation. Mol Immunol. 2014 Aug; 60(2):116-28. PMID: 24853397.
      View in: PubMed
    7. Zhang L, Londono P, Yu L, Grimes S, Blackburn P, Gottlieb P, Eisenbarth GS. MAS-1 adjuvant immunotherapy generates robust Th2 type and regulatory immune responses providing long-term protection from diabetes in late-stage pre-diabetic NOD mice. Autoimmunity. 2014 Aug; 47(5):341-50. PMID: 24783965.
      View in: PubMed
    8. Zhang L, Crawford F, Yu L, Michels A, Nakayama M, Davidson HW, Kappler JW, Eisenbarth GS. Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes. Proc Natl Acad Sci U S A. 2014 Feb 18; 111(7):2656-61. PMID: 24550292.
      View in: PubMed
    9. Zhang L, Stadinski BD, Michels A, Kappler JW, Eisenbarth GS. Immunization with an insulin peptide-MHC complex to prevent type 1 diabetes of NOD mice. Diabetes Metab Res Rev. 2011 Nov; 27(8):784-9. PMID: 22069260.
      View in: PubMed
    10. Michels AW, Ostrov DA, Zhang L, Nakayama M, Fuse M, McDaniel K, Roep BO, Gottlieb PA, Atkinson MA, Eisenbarth GS. Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation. J Immunol. 2011 Dec 01; 187(11):5921-30. PMID: 22043012.
      View in: PubMed
    11. Zhang L, Eisenbarth GS. Prediction and prevention of Type 1 diabetes mellitus. J Diabetes. 2011 Mar; 3(1):48-57. PMID: 21073664.
      View in: PubMed
    12. Stadinski BD, Zhang L, Crawford F, Marrack P, Eisenbarth GS, Kappler JW. Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):10978-83. PMID: 20534455.
      View in: PubMed
    13. Zhang L, Jin N, Nakayama M, O'Brien RL, Eisenbarth GS, Born WK. Gamma delta T cell receptors confer autonomous responsiveness to the insulin-peptide B:9-23. J Autoimmun. 2010 Jun; 34(4):478-84. PMID: 20080388.
      View in: PubMed
    14. Pang S, Zhang L, Wang H, Yi Z, Li L, Gao L, Zhao J, Tisch R, Katz JD, Wang B. CD8(+) T cells specific for beta cells encounter their cognate antigens in the islets of NOD mice. Eur J Immunol. 2009 Oct; 39(10):2716-24. PMID: 19658094.
      View in: PubMed
    15. Zhang L, Jasinski JM, Kobayashi M, Davenport B, Johnson K, Davidson H, Nakayama M, Haskins K, Eisenbarth GS. Analysis of T cell receptor beta chains that combine with dominant conserved TRAV5D-4*04 anti-insulin B:9-23 alpha chains. J Autoimmun. 2009 Aug; 33(1):42-9. PMID: 19286348.
      View in: PubMed
    16. Kobayashi M, Jasinski J, Liu E, Li M, Miao D, Zhang L, Yu L, Nakayama M, Eisenbarth GS. Conserved T cell receptor alpha-chain induces insulin autoantibodies. Proc Natl Acad Sci U S A. 2008 Jul 22; 105(29):10090-4. PMID: 18626021.
      View in: PubMed
    17. Zhang L, Nakayama M, Eisenbarth GS. Insulin as an autoantigen in NOD/human diabetes. Curr Opin Immunol. 2008 Feb; 20(1):111-8. PMID: 18178393.
      View in: PubMed
    18. Zhang L, Gianani R, Nakayama M, Liu E, Kobayashi M, Baschal E, Yu L, Babu S, Dawson A, Johnson K, Jahromi M, Aly T, Fain P, Barker J, Rewers M, Eisenbarth GS. Type 1 diabetes: chronic progressive autoimmune disease. Novartis Found Symp. 2008; 292:85-94; discussion 94-8, 122-9, 202-3. PMID: 19203094.
      View in: PubMed
    19. Sun Y, Zhang L, Gu HF, Han W, Ren M, Wang F, Gong B, Wang L, Guo H, Xin W, Zhao J, Gao L. Peroxisome proliferator-activated receptor-alpha regulates the expression of pancreatic/duodenal homeobox-1 in rat insulinoma (INS-1) cells and ameliorates glucose-induced insulin secretion impaired by palmitate. Endocrinology. 2008 Feb; 149(2):662-71. PMID: 17991720.
      View in: PubMed
    20. Zhang L, Barker JM, Babu S, Su M, Stenerson M, Cheng M, Shum A, Zamir E, Badolato R, Law A, Eisenbarth GS, Anderson MS. A robust immunoassay for anti-interferon autoantibodies that is highly specific for patients with autoimmune polyglandular syndrome type 1. Clin Immunol. 2007 Nov; 125(2):131-7. PMID: 17825626.
      View in: PubMed
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