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KRITHIKA LINGAPPAN

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Newborn
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    Collapse Biography 
    Collapse awards and honors
    2011AAP Young Investigator Award, The American Academy of Pediatrics, Section on Perinatal Pediatrics
    2012SSPR Young Investigator Award, Southern Society of Pediatric Research
    2012The Arnold J.Rudolph Award, Baylor College of Medicine
    2015SSPR Young Faculty Award, Southern Society of Pediatric Research
    2016SSPR Young Faculty Award, Southern Society of Pediatric research
    2017SSPR Young Faculty Award, Southern Society of Pediatric research

    Collapse Overview 
    Collapse overview
    My research focuses on reducing long term morbidities such as chronic lung disease (bronchopulmonary dysplasia) in premature babies. Specifically, our research focises on the elucidating the mechanisms behind sex-specific differences in the incidence of BPD. In the future, this research should lead to therapeutic lung-protective strategies. There is a great need for such therapeutic strategies to improve outcomes in premature babies, given that the incidence of BPD in premature neonates has been reported to be as high as 50%. The long-term goal of this research is to develop new translational strategies, both therapeutic and diagnostic in the field of neonatal lung injury.

    Collapse Research 
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    K08HL127103     (LINGAPPAN, KRITHIKA)May 1, 2015 - Apr 30, 2020
    NIH/NHLBI
    Mechanisms of sex specific differences in neonatal hyperoxic lung injury
    Role: Principal Investigator

    R03HL141572     (LINGAPPAN, KRITHIKA)May 5, 2018 - Apr 30, 2020
    NIH/NHLBI
    Sex-specific differences in neonatal hyperoxic lung injury: Role of the NF-kappa B pathway
    Role: Principal Investigator

    R01HL144775     (LINGAPPAN, KRITHIKA)Jul 1, 2019 - Jun 30, 2024
    NIH/NHLBI
    Mechanisms of sex differences in neonatal pulmonary oxygen toxicity
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Suter MA, Aagaard KM, Coarfa C, Robertson M, Zhou G, Jackson BP, Thompson D, Putluri V, Putluri N, Hagan J, Wang L, Jiang W, Lingappan K, Moorthy B. Association between elevated placental polycyclic aromatic hydrocarbons (PAHs) and PAH-DNA adducts from Superfund sites in Harris County, and increased risk of preterm birth (PTB). Biochem Biophys Res Commun. 2019 Jun 14. PMID: 31208719.
      View in: PubMed
    2. Zhang Y, Coarfa C, Dong X, Jiang W, Hayward-Piatkovskyi B, Gleghorn JP, Lingappan K. MicroRNA-30a as a candidate underlying sex-specific differences in neonatal hyperoxic lung injury: implications for BPD. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 01; 316(1):L144-L156. PMID: 30382766.
      View in: PubMed
    3. Veith AC, Bou Aram B, Jiang W, Wang L, Zhou G, Jefcoate CR, Couroucli XI, Lingappan K, Moorthy B. Mice Lacking the Cytochrome P450 1B1 Gene Are Less Susceptible to Hyperoxic Lung Injury Than Wild Type. Toxicol Sci. 2018 10 01; 165(2):462-474. PMID: 29939353.
      View in: PubMed
    4. Balaji S, Dong X, Li H, Zhang Y, Steen E, Lingappan K. Sex-specific differences in primary neonatal murine lung fibroblasts exposed to hyperoxia in vitro: implications for bronchopulmonary dysplasia. Physiol Genomics. 2018 11 01; 50(11):940-946. PMID: 30169132.
      View in: PubMed
    5. Zhang Y, Dong X, Shirazi J, Gleghorn JP, Lingappan K. Pulmonary endothelial cells exhibit sexual dimorphism in their response to hyperoxia. Am J Physiol Heart Circ Physiol. 2018 Nov 01; 315(5):H1287-H1292. PMID: 30095998.
      View in: PubMed
    6. Lingappan K, Arnold JL, Fernandes CJ, Pammi M. Videolaryngoscopy versus direct laryngoscopy for tracheal intubation in neonates. Cochrane Database Syst Rev. 2018 06 04; 6:CD009975. PMID: 29862490.
      View in: PubMed
    7. Thomas AN, Hagan JL, Lingappan K. Noninvasive ventilation strategies: which to choose? J Perinatol. 2018 May; 38(5):447-450. PMID: 29282353.
      View in: PubMed
    8. Pammi M, Lingappan K, Carbajal MM, Suresh GK. Focused Evidence-Based Medicine Curriculum for Trainees in Neonatal-Perinatal Medicine. MedEdPORTAL. 2017 Dec 26; 13:10664. PMID: 30800864.
      View in: PubMed
    9. Lingappan K, Maturu P, Liang YW, Jiang W, Wang L, Moorthy B, Couroucli XI. ß-Naphthoflavone treatment attenuates neonatal hyperoxic lung injury in wild type and Cyp1a2-knockout mice. Toxicol Appl Pharmacol. 2018 01 15; 339:133-142. PMID: 29180065.
      View in: PubMed
    10. Lingappan K. NF-?B in Oxidative Stress. Curr Opin Toxicol. 2018 Feb; 7:81-86. PMID: 29862377.
      View in: PubMed
    11. Jiang W, Maturu P, Liang YW, Wang L, Lingappan K, Couroucli X. Hyperoxia-mediated transcriptional activation of cytochrome P4501A1 (CYP1A1) and decreased susceptibility to oxygen-mediated lung injury in newborn mice. Biochem Biophys Res Commun. 2018 01 01; 495(1):408-413. PMID: 29101037.
      View in: PubMed
    12. Coarfa C, Zhang Y, Maity S, Perera DN, Jiang W, Wang L, Couroucli X, Moorthy B, Lingappan K. Sexual dimorphism of the pulmonary transcriptome in neonatal hyperoxic lung injury: identification of angiogenesis as a key pathway. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 01; 313(6):L991-L1005. PMID: 28818871.
      View in: PubMed
    13. Zhang Y, Jiang W, Wang L, Lingappan K. Sex-specific differences in the modulation of Growth Differentiation Factor 15 (GDF15) by hyperoxia in vivo and in vitro: Role of Hif-1a. Toxicol Appl Pharmacol. 2017 10 01; 332:8-14. PMID: 28734801.
      View in: PubMed
    14. Parmekar S, Arnold JL, Anselmo C, Pammi M, Hagan J, Fernandes CJ, Lingappan K. Mind the gap: can videolaryngoscopy bridge the competency gap in neonatal endotracheal intubation among pediatric trainees? a randomized controlled study. J Perinatol. 2017 08; 37(8):979-983. PMID: 28518132.
      View in: PubMed
    15. Maturu P, Wei-Liang Y, Jiang W, Wang L, Lingappan K, Barrios R, Liang Y, Moorthy B, Couroucli XI. Newborn Mice Lacking the Gene for Cyp1a1 Are More Susceptible to Oxygen-Mediated Lung Injury, and Are Rescued by Postnatal ß-Naphthoflavone Administration: Implications for Bronchopulmonary Dysplasia in Premature Infants. Toxicol Sci. 2017 05 01; 157(1):260-271. PMID: 28201809.
      View in: PubMed
    16. Lingappan K, Maity S, Jiang W, Wang L, Couroucli X, Veith A, Zhou G, Coarfa C, Moorthy B. Role of Cytochrome P450 (CYP)1A in Hyperoxic Lung Injury: Analysis of the Transcriptome and Proteome. Sci Rep. 2017 04 04; 7(1):642. PMID: 28377578.
      View in: PubMed
    17. Zhang Y, Lingappan K. Differential sex-specific effects of oxygen toxicity in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2017 04 29; 486(2):431-437. PMID: 28315681.
      View in: PubMed
    18. Hoover J, Lingappan K. One-Month-Old Infant With Hypotonia and Cardiorespiratory Arrest. Clin Pediatr (Phila). 2017 04; 56(4):397-398. PMID: 27356634.
      View in: PubMed
    19. Lingappan K, Jiang W, Wang L, Moorthy B. Sex-specific differences in neonatal hyperoxic lung injury. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 01; 311(2):L481-93. PMID: 27343189.
      View in: PubMed
    20. Dinu D, Chu C, Veith A, Lingappan K, Couroucli X, Jefcoate CR, Sheibani N, Moorthy B. Mechanistic role of cytochrome P450 (CYP)1B1 in oxygen-mediated toxicity in pulmonary cells: A novel target for prevention of hyperoxic lung injury. Biochem Biophys Res Commun. 2016 08 05; 476(4):346-351. PMID: 27235555.
      View in: PubMed
    21. Lingappan K, Kaiser JR, Srinivasan C, Gunn AJ. Relationship between PCO2 and unfavorable outcome in infants with moderate-to-severe hypoxic ischemic encephalopathy. Pediatr Res. 2016 08; 80(2):204-8. PMID: 27049290.
      View in: PubMed
    22. Lingappan K, Moorthy B. Can maternal DHA supplementation offer long-term protection against neonatal hyperoxic lung injury? Am J Physiol Lung Cell Mol Physiol. 2015 Dec 15; 309(12):L1383-6. PMID: 26361877.
      View in: PubMed
    23. Tiwari KK, Moorthy B, Lingappan K. Role of GDF15 (growth and differentiation factor 15) in pulmonary oxygen toxicity. Toxicol In Vitro. 2015 Oct; 29(7):1369-76. PMID: 26004619.
      View in: PubMed
    24. Lingappan K, Jiang W, Wang L, Couroucli XI, Moorthy B. Sex-specific differences in hyperoxic lung injury in mice: role of cytochrome P450 (CYP)1A. Toxicology. 2015 May 04; 331:14-23. PMID: 25703676.
      View in: PubMed
    25. Lingappan K, Arnold JL, Shaw TL, Fernandes CJ, Pammi M. Videolaryngoscopy versus direct laryngoscopy for tracheal intubation in neonates. Cochrane Database Syst Rev. 2015 Feb 18; (2):CD009975. PMID: 25691129.
      View in: PubMed
    26. Wang L, Lingappan K, Jiang W, Couroucli XI, Welty SE, Shivanna B, Barrios R, Wang G, Firoze Khan M, Gonzalez FJ, Jackson Roberts L, Moorthy B. Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury. Free Radic Biol Med. 2015 May; 82:147-59. PMID: 25680282.
      View in: PubMed
    27. Lingappan K, Srinivasan C, Jiang W, Wang L, Couroucli XI, Moorthy B. Analysis of the transcriptome in hyperoxic lung injury and sex-specific alterations in gene expression. PLoS One. 2014; 9(7):e101581. PMID: 25003466.
      View in: PubMed
    28. Tiwari KK, Chu C, Couroucli X, Moorthy B, Lingappan K. Differential concentration-specific effects of caffeine on cell viability, oxidative stress, and cell cycle in pulmonary oxygen toxicity in vitro. Biochem Biophys Res Commun. 2014 Aug 08; 450(4):1345-50. PMID: 24997337.
      View in: PubMed
    29. Lingappan K, Jiang W, Wang L, Wang G, Couroucli XI, Shivanna B, Welty SE, Barrios R, Khan MF, Nebert DW, Roberts LJ, Moorthy B. Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: evidence for protective role of CYP1A1 against oxidative stress. Toxicol Sci. 2014 Sep; 141(1):68-77. PMID: 24893714.
      View in: PubMed
    30. Thakur VS, Liang YW, Lingappan K, Jiang W, Wang L, Barrios R, Zhou G, Guntupalli B, Shivanna B, Maturu P, Welty SE, Moorthy B, Couroucli XI. Increased susceptibility to hyperoxic lung injury and alveolar simplification in newborn rats by prenatal administration of benzo[a]pyrene. Toxicol Lett. 2014 Oct 15; 230(2):322-32. PMID: 24657529.
      View in: PubMed
    31. Lingappan K, Arunachalam A, Pammi M. Lactoferrin and the newborn: current perspectives. Expert Rev Anti Infect Ther. 2013 Jul; 11(7):695-707. PMID: 23879609.
      View in: PubMed
    32. Lingappan K, Jiang W, Wang L, Couroucli XI, Barrios R, Moorthy B. Sex-specific differences in hyperoxic lung injury in mice: implications for acute and chronic lung disease in humans. Toxicol Appl Pharmacol. 2013 Oct 15; 272(2):281-90. PMID: 23792423.
      View in: PubMed
    33. Singh M, Lingappan K. Whooping cough: the current scene. Chest. 2006 Nov; 130(5):1547-53. PMID: 17099036.
      View in: PubMed
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