KRITHIKA LINGAPPAN

TitleAdjunct Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
Houston, TX 77030
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    Collapse Biography 
    Collapse awards and honors
    2011AAP Young Investigator Award, The American Academy of Pediatrics, Section on Perinatal Pediatrics
    2012SSPR Young Investigator Award, Southern Society of Pediatric Research
    2012The Arnold J.Rudolph Award, Baylor College of Medicine
    2015SSPR Young Faculty Award, Southern Society of Pediatric Research
    2016SSPR Young Faculty Award, Southern Society of Pediatric research
    2017SSPR Young Faculty Award, Southern Society of Pediatric research
    2019Young Investigator Award, Department of Pediatrics, Baylor College of Medicine
    2019Norton Rose Fulbright Award for Teaching and Evaluation, Baylor College of Medicine
    2019Woman of Excellence Award, Baylor College of Medcine
    2020 - 2024Leveraging multi-omics and advanced mouse models to delineate mechanisms underlying sex-specific dif, NHLBI
    2019 - 2024Mechanisms of sex differences in neonatal pulmonary oxygen toxicity , NHLBI

    Collapse Overview 
    Collapse overview
    My research focuses on reducing long term morbidities such as chronic lung disease (bronchopulmonary dysplasia) in premature babies. Specifically, our research focises on the elucidating the mechanisms behind sex-specific differences in the incidence of BPD. In the future, this research should lead to therapeutic lung-protective strategies. There is a great need for such therapeutic strategies to improve outcomes in premature babies, given that the incidence of BPD in premature neonates has been reported to be as high as 50%. The long-term goal of this research is to develop new translational strategies, both therapeutic and diagnostic in the field of neonatal lung injury.

    Collapse Research 
    Collapse research activities and funding
    K08HL127103     (LINGAPPAN, KRITHIKA)May 1, 2015 - Apr 30, 2020
    NIH
    Mechanisms of sex specific differences in neonatal hyperoxic lung injury
    Role: Principal Investigator

    R03HL141572     (LINGAPPAN, KRITHIKA)May 5, 2018 - Apr 30, 2020
    NIH
    Sex-specific differences in neonatal hyperoxic lung injury: Role of the NF-kappa B pathway
    Role: Principal Investigator

    R01HL144775     (LINGAPPAN, KRITHIKA)Jul 1, 2019 - Jun 30, 2024
    NIH
    Mechanisms of sex differences in neonatal pulmonary oxygen toxicity
    Role: Principal Investigator

    R01HL146395     (LINGAPPAN, KRITHIKA)May 15, 2020 - Apr 30, 2024
    NIH
    Leveraging multiomics and advanced mouse models to delineate mechanisms underlying sex?specific differences in recovery and repair after neonatal hyperoxia exposure in the developing lung
    Role: Principal Investigator

    R21HD100862     (LINGAPPAN, KRITHIKA)Jun 23, 2020 - May 31, 2022
    NIH
    Sex as biological variable in Bronchopulmonary Dysplasia: Role of the Notch pathway
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lingappan K. Does the Epigenome Hold Clues to Leptin-associated Hypertension in Obesity? Am J Respir Cell Mol Biol. 2021 08; 65(2):132-133. PMID: 34029509.
      Citations:    Fields:    Translation:Humans
    2. Koo J, Lingappan K, Song C. National professional society augments career development and leadership amongst neonatal fellows and early career neonatologists. J Perinatol. 2021 Jul 22. PMID: 34294879.
      Citations:    Fields:    
    3. Grimm SL, Dong X, Zhang Y, Carisey AF, Arnold AP, Moorthy B, Coarfa C, Lingappan K. Effect of sex chromosomes versus hormones in neonatal lung injury. JCI Insight. 2021 Jul 08; 6(13). PMID: 34061778.
      Citations:    Fields:    
    4. Jain PN, Robertson M, Lasa JJ, Shekerdemian L, Guffey D, Zhang Y, Lingappan K, Checchia P, Coarfa C. Altered metabolic and inflammatory transcriptomics after cardiac surgery in neonates with congenital heart disease. Sci Rep. 2021 Mar 02; 11(1):4965. PMID: 33654130.
      Citations: 1     Fields:    
    5. Stading R, Couroucli X, Lingappan K, Moorthy B. The role of cytochrome P450 (CYP) enzymes in hyperoxic lung injury. Expert Opin Drug Metab Toxicol. 2021 Feb; 17(2):171-178. PMID: 33215946.
      Citations: 2     Fields:    Translation:HumansAnimals
    6. Al-Mudares F, Reddick S, Ren J, Venkatesh A, Zhao C, Lingappan K. Role of Growth Differentiation Factor 15 in Lung Disease and Senescence: Potential Role Across the Lifespan. Front Med (Lausanne). 2020; 7:594137. PMID: 33344478.
      Citations: 2     
    7. Coarfa C, Grimm SL, Katz T, Zhang Y, Jangid RK, Walker CL, Moorthy B, Lingappan K. Epigenetic response to hyperoxia in the neonatal lung is sexually dimorphic. Redox Biol. 2020 10; 37:101718. PMID: 32961439.
      Citations: 3     Fields:    Translation:Animals
    8. Callaway DA, Jiang W, Wang L, Lingappan K, Moorthy B. Oxygen-mediated lung injury in mice lacking the gene for NRF2: Rescue with the cytochrome P4501A-inducer, beta-naphthoflavone (BNF), and differential sex-specific effects. Free Radic Biol Med. 2020 11 20; 160:208-218. PMID: 32791187.
      Citations:    Fields:    Translation:HumansAnimals
    9. Stading R, Chu C, Couroucli X, Lingappan K, Moorthy B. Molecular role of cytochrome P4501A enzymes inoxidative stress. Curr Opin Toxicol. 2020 Apr-Jun; 20-21:77-84. PMID: 33283080.
      Citations:    
    10. Lingappan K, Savani RC. The Wnt Signaling Pathway and the Development of Bronchopulmonary Dysplasia. Am J Respir Crit Care Med. 2020 05 15; 201(10):1174-1176. PMID: 32101467.
      Citations: 2     Fields:    Translation:HumansCells
    11. Zhang Y, Dong X, Lingappan K. Role of HIF-1a-miR30a-Snai1 Axis in Neonatal Hyperoxic Lung Injury. Oxid Med Cell Longev. 2019; 2019:8327486. PMID: 31772711.
      Citations: 5     Fields:    Translation:HumansAnimals
    12. Althouse MH, Stewart C, Jiang W, Moorthy B, Lingappan K. Impact of Early Life Antibiotic Exposure and Neonatal Hyperoxia on the Murine Microbiome and Lung Injury. Sci Rep. 2019 10 18; 9(1):14992. PMID: 31628395.
      Citations: 2     Fields:    Translation:Animals
    13. Suter MA, Aagaard KM, Coarfa C, Robertson M, Zhou G, Jackson BP, Thompson D, Putluri V, Putluri N, Hagan J, Wang L, Jiang W, Lingappan K, Moorthy B. Association between elevated placental polycyclic aromatic hydrocarbons (PAHs) and PAH-DNA adducts from Superfund sites in Harris County, and increased risk of preterm birth (PTB). Biochem Biophys Res Commun. 2019 08 20; 516(2):344-349. PMID: 31208719.
      Citations: 8     Fields:    Translation:HumansPHPublic Health
    14. Zhang Y, Coarfa C, Dong X, Jiang W, Hayward-Piatkovskyi B, Gleghorn JP, Lingappan K. MicroRNA-30a as a candidate underlying sex-specific differences in neonatal hyperoxic lung injury: implications for BPD. Am J Physiol Lung Cell Mol Physiol. 2019 01 01; 316(1):L144-L156. PMID: 30382766.
      Citations: 6     Fields:    Translation:AnimalsCells
    15. Veith AC, Bou Aram B, Jiang W, Wang L, Zhou G, Jefcoate CR, Couroucli XI, Lingappan K, Moorthy B. Mice Lacking the Cytochrome P450 1B1 Gene Are Less Susceptible to Hyperoxic Lung Injury Than Wild Type. Toxicol Sci. 2018 10 01; 165(2):462-474. PMID: 29939353.
      Citations: 5     Fields:    Translation:AnimalsCells
    16. Balaji S, Dong X, Li H, Zhang Y, Steen E, Lingappan K. Sex-specific differences in primary neonatal murine lung fibroblasts exposed to hyperoxia in vitro: implications for bronchopulmonary dysplasia. Physiol Genomics. 2018 11 01; 50(11):940-946. PMID: 30169132.
      Citations: 3     Fields:    Translation:AnimalsCells
    17. Zhang Y, Dong X, Shirazi J, Gleghorn JP, Lingappan K. Pulmonary endothelial cells exhibit sexual dimorphism in their response to hyperoxia. Am J Physiol Heart Circ Physiol. 2018 11 01; 315(5):H1287-H1292. PMID: 30095998.
      Citations: 12     Fields:    Translation:HumansCells
    18. Lingappan K, Arnold JL, Fernandes CJ, Pammi M. Videolaryngoscopy versus direct laryngoscopy for tracheal intubation in neonates. Cochrane Database Syst Rev. 2018 06 04; 6:CD009975. PMID: 29862490.
      Citations: 13     Fields:    Translation:Humans
    19. Thomas AN, Hagan JL, Lingappan K. Noninvasive ventilation strategies: which to choose? J Perinatol. 2018 05; 38(5):447-450. PMID: 29282353.
      Citations:    Fields:    Translation:Humans
    20. Pammi M, Lingappan K, Carbajal MM, Suresh GK. Focused Evidence-Based Medicine Curriculum for Trainees in Neonatal-Perinatal Medicine. MedEdPORTAL. 2017 12 26; 13:10664. PMID: 30800864.
      Citations: 2     Fields:    Translation:Humans
    21. Lingappan K, Maturu P, Liang YW, Jiang W, Wang L, Moorthy B, Couroucli XI. ß-Naphthoflavone treatment attenuates neonatal hyperoxic lung injury in wild type and Cyp1a2-knockout mice. Toxicol Appl Pharmacol. 2018 01 15; 339:133-142. PMID: 29180065.
      Citations:    Fields:    Translation:Animals
    22. Lingappan K. NF-?B in Oxidative Stress. Curr Opin Toxicol. 2018 Feb; 7:81-86. PMID: 29862377.
      Citations: 86     
    23. Jiang W, Maturu P, Liang YW, Wang L, Lingappan K, Couroucli X. Hyperoxia-mediated transcriptional activation of cytochrome P4501A1 (CYP1A1) and decreased susceptibility to oxygen-mediated lung injury in newborn mice. Biochem Biophys Res Commun. 2018 01 01; 495(1):408-413. PMID: 29101037.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    24. Coarfa C, Zhang Y, Maity S, Perera DN, Jiang W, Wang L, Couroucli X, Moorthy B, Lingappan K. Sexual dimorphism of the pulmonary transcriptome in neonatal hyperoxic lung injury: identification of angiogenesis as a key pathway. Am J Physiol Lung Cell Mol Physiol. 2017 Dec 01; 313(6):L991-L1005. PMID: 28818871.
      Citations: 9     Translation:AnimalsCells
    25. Zhang Y, Jiang W, Wang L, Lingappan K. Sex-specific differences in the modulation of Growth Differentiation Factor 15 (GDF15) by hyperoxia in vivo and in vitro: Role of Hif-1a. Toxicol Appl Pharmacol. 2017 10 01; 332:8-14. PMID: 28734801.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    26. Maturu P, Wei-Liang Y, Jiang W, Wang L, Lingappan K, Barrios R, Liang Y, Moorthy B, Couroucli XI. Newborn Mice Lacking the Gene for Cyp1a1 Are More Susceptible to Oxygen-Mediated Lung Injury, and Are Rescued by Postnatal ß-Naphthoflavone Administration: Implications for Bronchopulmonary Dysplasia in Premature Infants. Toxicol Sci. 2017 05 01; 157(1):260-271. PMID: 28201809.
      Citations: 11     Fields:    Translation:HumansAnimals
    27. Lingappan K, Maity S, Jiang W, Wang L, Couroucli X, Veith A, Zhou G, Coarfa C, Moorthy B. Role of Cytochrome P450 (CYP)1A in Hyperoxic Lung Injury: Analysis of the Transcriptome and Proteome. Sci Rep. 2017 04 04; 7(1):642. PMID: 28377578.
      Citations: 9     Fields:    Translation:AnimalsCells
    28. Zhang Y, Lingappan K. Differential sex-specific effects of oxygen toxicity in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2017 04 29; 486(2):431-437. PMID: 28315681.
      Citations: 11     Fields:    Translation:HumansCells
    29. Hoover J, Lingappan K. One-Month-Old Infant With Hypotonia and Cardiorespiratory Arrest. Clin Pediatr (Phila). 2017 04; 56(4):397-398. PMID: 27356634.
      Citations:    Fields:    Translation:Humans
    30. Lingappan K, Jiang W, Wang L, Moorthy B. Sex-specific differences in neonatal hyperoxic lung injury. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 01; 311(2):L481-93. PMID: 27343189.
      Citations: 32     Translation:Animals
    31. Dinu D, Chu C, Veith A, Lingappan K, Couroucli X, Jefcoate CR, Sheibani N, Moorthy B. Mechanistic role of cytochrome P450 (CYP)1B1 in oxygen-mediated toxicity in pulmonary cells: A novel target for prevention of hyperoxic lung injury. Biochem Biophys Res Commun. 2016 08 05; 476(4):346-351. PMID: 27235555.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    32. Lingappan K, Kaiser JR, Srinivasan C, Gunn AJ. Relationship between PCO2 and unfavorable outcome in infants with moderate-to-severe hypoxic ischemic encephalopathy. Pediatr Res. 2016 08; 80(2):204-8. PMID: 27049290.
      Citations: 12     Fields:    Translation:Humans
    33. Lingappan K, Moorthy B. Can maternal DHA supplementation offer long-term protection against neonatal hyperoxic lung injury? Am J Physiol Lung Cell Mol Physiol. 2015 Dec 15; 309(12):L1383-6. PMID: 26361877.
      Citations:    Translation:HumansAnimals
    34. Tiwari KK, Moorthy B, Lingappan K. Role of GDF15 (growth and differentiation factor 15) in pulmonary oxygen toxicity. Toxicol In Vitro. 2015 Oct; 29(7):1369-76. PMID: 26004619.
      Citations: 16     Fields:    Translation:HumansCells
    35. Lingappan K, Jiang W, Wang L, Couroucli XI, Moorthy B. Sex-specific differences in hyperoxic lung injury in mice: role of cytochrome P450 (CYP)1A. Toxicology. 2015 May 04; 331:14-23. PMID: 25703676.
      Citations: 16     Fields:    Translation:Animals
    36. Lingappan K, Arnold JL, Shaw TL, Fernandes CJ, Pammi M. Videolaryngoscopy versus direct laryngoscopy for tracheal intubation in neonates. Cochrane Database Syst Rev. 2015 Feb 18; (2):CD009975. PMID: 25691129.
      Citations: 7     Fields:    Translation:Humans
    37. Wang L, Lingappan K, Jiang W, Couroucli XI, Welty SE, Shivanna B, Barrios R, Wang G, Firoze Khan M, Gonzalez FJ, Jackson Roberts L, Moorthy B. Disruption of cytochrome P4501A2 in mice leads to increased susceptibility to hyperoxic lung injury. Free Radic Biol Med. 2015 May; 82:147-59. PMID: 25680282.
      Citations: 15     Fields:    Translation:AnimalsCells
    38. Lingappan K, Srinivasan C, Jiang W, Wang L, Couroucli XI, Moorthy B. Analysis of the transcriptome in hyperoxic lung injury and sex-specific alterations in gene expression. PLoS One. 2014; 9(7):e101581. PMID: 25003466.
      Citations: 17     Fields:    Translation:AnimalsCells
    39. Tiwari KK, Chu C, Couroucli X, Moorthy B, Lingappan K. Differential concentration-specific effects of caffeine on cell viability, oxidative stress, and cell cycle in pulmonary oxygen toxicity in vitro. Biochem Biophys Res Commun. 2014 Aug 08; 450(4):1345-50. PMID: 24997337.
      Citations: 8     Fields:    Translation:AnimalsCells
    40. Lingappan K, Jiang W, Wang L, Wang G, Couroucli XI, Shivanna B, Welty SE, Barrios R, Khan MF, Nebert DW, Roberts LJ, Moorthy B. Mice deficient in the gene for cytochrome P450 (CYP)1A1 are more susceptible than wild-type to hyperoxic lung injury: evidence for protective role of CYP1A1 against oxidative stress. Toxicol Sci. 2014 Sep; 141(1):68-77. PMID: 24893714.
      Citations: 20     Fields:    Translation:AnimalsCells
    41. Thakur VS, Liang YW, Lingappan K, Jiang W, Wang L, Barrios R, Zhou G, Guntupalli B, Shivanna B, Maturu P, Welty SE, Moorthy B, Couroucli XI. Increased susceptibility to hyperoxic lung injury and alveolar simplification in newborn rats by prenatal administration of benzo[a]pyrene. Toxicol Lett. 2014 Oct 15; 230(2):322-32. PMID: 24657529.
      Citations: 11     Fields:    Translation:Animals
    42. Lingappan K, Arunachalam A, Pammi M. Lactoferrin and the newborn: current perspectives. Expert Rev Anti Infect Ther. 2013 Jul; 11(7):695-707. PMID: 23879609.
      Citations: 7     Fields:    Translation:HumansAnimals
    43. Lingappan K, Jiang W, Wang L, Couroucli XI, Barrios R, Moorthy B. Sex-specific differences in hyperoxic lung injury in mice: implications for acute and chronic lung disease in humans. Toxicol Appl Pharmacol. 2013 Oct 15; 272(2):281-90. PMID: 23792423.
      Citations: 24     Fields:    Translation:HumansAnimals
    44. Singh M, Lingappan K. Whooping cough: the current scene. Chest. 2006 Nov; 130(5):1547-53. PMID: 17099036.
      Citations: 15     Fields:    Translation:HumansCellsPHPublic Health
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