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KEITH CHAN

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Urology
DivisionUrology
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    K99CA129640     (CHAN, KEITH SYSON)Aug 15, 2007 - Aug 31, 2009
    NIH/NCI
    Identification and characterization of bladder cancer stem cells
    Role: Principal Investigator

    R00CA129640     (CHAN, KEITH SYSON)Aug 15, 2007 - Aug 31, 2012
    NIH/NCI
    Identification and characterization of bladder cancer stem cells
    Role: Principal Investigator

    R01CA175397     (CHAN, KEITH SYSON)Sep 30, 2013 - Aug 31, 2019
    NIH/NCI
    Cancer-associated fibroblast in the regulation of bladder cancer stem cells
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kamoun A, Reyniès A, Allory Y, Sjödahl G, Gordon Robertson A, Seiler R, Hoadley KA, Groeneveld CS, Al-Ahmadie H, Choi W, Castro MAA, Fontugne J, Eriksson P, Mo Q, Kardos J, Zlotta A, Hartmann A, Dinney CP, Bellmunt J, Powles T, Malats N, Chan KS, Kim WY, McConkey DJ, Black PC, Dyrskjøt L, Höglund M, Lerner SP, Real FX, Radvanyi F. A Consensus Molecular Classification of Muscle-invasive Bladder Cancer. Eur Urol. 2019 Sep 25. PMID: 31563503.
      View in: PubMed
    2. Lee YC, Kurtova AV, Xiao J, Nikolos F, Hayashi K, Tramel Z, Jain A, Chen F, Chokshi M, Lee C, Bao G, Zhang X, Shen J, Mo Q, Jung SY, Rowley D, Chan KS. Collagen-rich airway smooth muscle cells are a metastatic niche for tumor colonization in the lung. Nat Commun. 2019 05 13; 10(1):2131. PMID: 31086186.
      View in: PubMed
    3. Mo Q, Nikolos F, Chen F, Tramel Z, Lee YC, Hayashi K, Xiao J, Shen J, Chan KS. Prognostic Power of a Tumor Differentiation Gene Signature for Bladder Urothelial Carcinomas. J Natl Cancer Inst. 2018 05 01; 110(5):448-459. PMID: 29342309.
      View in: PubMed
    4. Mo Q, Shen R, Guo C, Vannucci M, Chan KS, Hilsenbeck SG. A fully Bayesian latent variable model for integrative clustering analysis of multi-type omics data. Biostatistics. 2018 01 01; 19(1):71-86. PMID: 28541380.
      View in: PubMed
    5. Rodriguez-Brenes IA, Kurtova AV, Lin C, Lee YC, Xiao J, Mims M, Chan KS, Wodarz D. Cellular Hierarchy as a Determinant of Tumor Sensitivity to Chemotherapy. Cancer Res. 2017 05 01; 77(9):2231-2241. PMID: 28235762.
      View in: PubMed
    6. Brooks M, Mo Q, Krasnow R, Ho PL, Lee YC, Xiao J, Kurtova A, Lerner S, Godoy G, Jian W, Castro P, Chen F, Rowley D, Ittmann M, Chan KS. Positive association of collagen type I with non-muscle invasive bladder cancer progression. Oncotarget. 2016 Dec 13; 7(50):82609-82619. PMID: 27655672.
      View in: PubMed
    7. Lerner SP, McConkey DJ, Hoadley KA, Chan KS, Kim WY, Radvanyi F, Höglund M, Real FX. Bladder Cancer Molecular Taxonomy: Summary from a Consensus Meeting. Bladder Cancer. 2016 Jan 07; 2(1):37-47. PMID: 27376123.
      View in: PubMed
    8. Chan KS. Molecular Pathways: Targeting Cancer Stem Cells Awakened by Chemotherapy to Abrogate Tumor Repopulation. Clin Cancer Res. 2016 Feb 15; 22(4):802-6. PMID: 26671994.
      View in: PubMed
    9. Kurtova AV, Xiao J, Mo Q, Pazhanisamy S, Krasnow R, Lerner SP, Chen F, Roh TT, Lay E, Ho PL, Chan KS. Blocking PGE2-induced tumour repopulation abrogates bladder cancer chemoresistance. Nature. 2015 Jan 08; 517(7533):209-13. PMID: 25470039.
      View in: PubMed
    10. Kim W, Barron DA, San Martin R, Chan KS, Tran LL, Yang F, Ressler SJ, Rowley DR. RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiation. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16389-94. PMID: 25313057.
      View in: PubMed
    11. Ho PL, Kurtova A, Chan KS. Normal and neoplastic urothelial stem cells: getting to the root of the problem. Nat Rev Urol. 2012 Oct; 9(10):583-94. PMID: 22890301.
      View in: PubMed
    12. Ho PL, Lay EJ, Jian W, Parra D, Chan KS. Stat3 activation in urothelial stem cells leads to direct progression to invasive bladder cancer. Cancer Res. 2012 Jul 01; 72(13):3135-42. PMID: 22532166.
      View in: PubMed
    13. Volkmer JP, Sahoo D, Chin RK, Ho PL, Tang C, Kurtova AV, Willingham SB, Pazhanisamy SK, Contreras-Trujillo H, Storm TA, Lotan Y, Beck AH, Chung BI, Alizadeh AA, Godoy G, Lerner SP, van de Rijn M, Shortliffe LD, Weissman IL, Chan KS. Three differentiation states risk-stratify bladder cancer into distinct subtypes. Proc Natl Acad Sci U S A. 2012 Feb 07; 109(6):2078-83. PMID: 22308455.
      View in: PubMed
    14. Chan KS, Volkmer JP, Weissman I. Cancer stem cells in bladder cancer: a revisited and evolving concept. Curr Opin Urol. 2010 Sep; 20(5):393-7. PMID: 20657288.
      View in: PubMed
    15. Chan KS, Espinosa I, Chao M, Wong D, Ailles L, Diehn M, Gill H, Presti J, Chang HY, van de Rijn M, Shortliffe L, Weissman IL. Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proc Natl Acad Sci U S A. 2009 Aug 18; 106(33):14016-21. PMID: 19666525.
      View in: PubMed
    16. Chan KS, Sano S, Kataoka K, Abel E, Carbajal S, Beltran L, Clifford J, Peavey M, Shen J, Digiovanni J. Forced expression of a constitutively active form of Stat3 in mouse epidermis enhances malignant progression of skin tumors induced by two-stage carcinogenesis. Oncogene. 2008 Feb 14; 27(8):1087-94. PMID: 17700521.
      View in: PubMed
    17. Kim DJ, Chan KS, Sano S, Digiovanni J. Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis. Mol Carcinog. 2007 Aug; 46(8):725-31. PMID: 17610223.
      View in: PubMed
    18. Sano S, Chan KS, DiGiovanni J. Impact of Stat3 activation upon skin biology: a dichotomy of its role between homeostasis and diseases. J Dermatol Sci. 2008 Apr; 50(1):1-14. PMID: 17601706.
      View in: PubMed
    19. Sano S, Chan KS, Kira M, Kataoka K, Takagi S, Tarutani M, Itami S, Kiguchi K, Yokoi M, Sugasawa K, Mori T, Hanaoka F, Takeda J, DiGiovanni J. Signal transducer and activator of transcription 3 is a key regulator of keratinocyte survival and proliferation following UV irradiation. Cancer Res. 2005 Jul 01; 65(13):5720-9. PMID: 15994947.
      View in: PubMed
    20. Sano S, Chan KS, Carbajal S, Clifford J, Peavey M, Kiguchi K, Itami S, Nickoloff BJ, DiGiovanni J. Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nat Med. 2005 Jan; 11(1):43-9. PMID: 15592573.
      View in: PubMed
    21. Chan KS, Sano S, Kiguchi K, Anders J, Komazawa N, Takeda J, DiGiovanni J. Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis. J Clin Invest. 2004 Sep; 114(5):720-8. PMID: 15343391.
      View in: PubMed
    22. Chan KS, Carbajal S, Kiguchi K, Clifford J, Sano S, DiGiovanni J. Epidermal growth factor receptor-mediated activation of Stat3 during multistage skin carcinogenesis. Cancer Res. 2004 Apr 01; 64(7):2382-9. PMID: 15059889.
      View in: PubMed
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