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KATHERINE KING

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Infectious Diseases
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    Collapse ORNG Applications 
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    Collapse Biography 
    Collapse education and training
    Harvard University, CambridgeAB06/1996Biochemical Sciences
    Washington University, St. LouisMD PhD06/2003Molecular Microbiology and Microbial Pathogenesis
    Baylor College of Medicine, Houstonresidency06/2006Pediatrics
    Baylor College of Medicine, Houstonfellowship06/2010Infectious Diseases
    Collapse awards and honors
    2015 - 2017Liviya Anderson Research Award, Aplastic Anemia and MDS International Foundation
    2015 - 2017Basil O'Connor Starter Scholar Award, March of Dimes
    2014 - 2015BCM Junior Faculty Seed Grant, Caroline Wiess Law Fund for Research in Molecular Medicine
    2010 - 2015KO8 Mentored Clinical Scientist Training Award, NIH
    2011 - 2012Pediatric Pilot Award, Texas Children's Hospital
    2008 - 2009Collaborative Research Grant, L.E. and Virginia Simmons Family Foundation
    2017 - 2018New Member Outstanding Science Award, Society for Pediatric Research
    2017 - 2018Woman of Excellence Award, Baylor College of Medicine

    Collapse Overview 
    Collapse overview
    The long-term goal of Dr. King’s research is to alleviate deaths from infectious diseases. Given that severe infections are frequently related to weaknesses in the immune system, Dr. King’s research focuses on the molecular mechanisms by which inflammation affects blood and immune cell production by hematopoietic stem cells in the bone marrow. Dr. King has been the recipient of a NIH K08 mentored physician scientist training award, the March of Dimes Basil O’Connor Starter Scholar Award, the Aplastic Anemia and MDS International Foundation Liviya Anderson Award, and the Caroline Wiess Law Foundation in Molecular Medicine Award. Her research has been published in highly regarded journals such as Nature, Cell Reports, and Blood.

    Current projects in the lab include:

    Inflammatory Regulation of Hematopoietic Stem and Progenitor Cells to Enhance Innate Immunity
    We are studying the therapeutic use of hematopoietic stem and progenitors to improve immune responses against bacterial infections including Group A Streptococcal superinfections complicating influenza. Funding to support this project: NIH R01, 2017-2021

    The Contribution of Infection to Preleukemic Clonal Hematopoiesis
    We are studying how the differential responses of hematopoietic stem cells to inflammation contribute to emergence of leukemia. These studies provide a mechanistic understanding of how infections affect cancer risk. Funding to support this project: NIH R01, 2017-2022

    Microbiota-dependent Regulation of Primitive Hematopoiesis
    An adverse side effect of antibiotics is that they may suppress blood and immune cell production by the bone marrow. In a study published last year, we demonstrated that these adverse effects of antibiotics are due to disruption of the intestinal microbiome. Our current work will define the molecular pathways through which the microbiome signals to support normal blood production. Funding to supporting this project: NIH R01 (co-investigator), 2018-2023

    Collapse Research 
    Collapse research activities and funding
    K08HL098898     (KING, KATHERINE YUDEH)May 1, 2010 - Feb 28, 2015
    NIH/NHLBI
    The Role of Interferon-gamma in the Regulation of Hematopoietic Stem Cells
    Role: Principal Investigator

    R01HL136333     (KING, KATHERINE YUDEH)May 1, 2017 - Apr 30, 2023
    NIH/NHLBI
    The Contribution ofInfection to Preleukemic Clonal Hematopoiesis
    Role: Principal Investigator

    R01HL134880     (KING, KATHERINE YUDEH)Aug 1, 2017 - Jun 30, 2021
    NIH/NHLBI
    Inflammatory Regulation of Hematopoietic Stem and Progenitor Cells to Enhance Innate Immunity
    Role: Principal Investigator

    R01AI141716     (BALDRIDGE, MEGAN T)Nov 7, 2018 - Oct 31, 2023
    NIH
    Microbiota-dependent regulation of primitive hematopoieses
    Role Description: The goal of this study is to quantify the impact of a variety of environmental stressors on clonal dynamics of a panel of genetically distinct hematopoietic stem cell clones.
    Role: Co-PI

         (Margaret Goodell)Jul 1, 2019 - Jun 30, 2022
    Helis Medical Research Foundation
    Environmental Drivers of Clonal Hematopoiesis
    Role: Co-PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Hormaechea-Agulla D, Le DT, King KY. Common Sources of Inflammation and Their Impact on Hematopoietic Stem Cell Biology. Curr Stem Cell Rep. 2020 Aug 17; 1-12. PMID: 32837857.
      View in: PubMed
    2. King KY, Huang Y, Nakada D, Goodell MA. Environmental influences on clonal hematopoiesis. Exp Hematol. 2020 03; 83:66-73. PMID: 31893524.
      View in: PubMed
    3. Niles D, Boguniewicz J, Shakeel O, Margolin J, Chelius D, Gupta M, Paul D, King KY, McNeil JC. Candida tropicalis Thyroiditis Presenting With Thyroid Storm in a Pediatric Patient With Acute Lymphocytic Leukemia. Pediatr Infect Dis J. 2019 10; 38(10):1051-1053. PMID: 31365478.
      View in: PubMed
    4. Zeng H, He H, Guo L, Li J, Lee M, Han W, Guzman AG, Zang S, Zhou Y, Zhang X, Goodell MA, King KY, Sun D, Huang Y. Antibiotic treatment ameliorates Ten-eleven translocation 2 (TET2) loss-of-function associated hematological malignancies. Cancer Lett. 2019 12 28; 467:1-8. PMID: 31563562.
      View in: PubMed
    5. Foster CE, Taylor M, Schallert EK, Rosenfeld S, King KY. Brodie Abscess in Children: A 10-Year Single Institution Retrospective Review. Pediatr Infect Dis J. 2019 02; 38(2):e32-e34. PMID: 29620720.
      View in: PubMed
    6. Kennedy EA, King KY, Baldridge MT. Mouse Microbiota Models: Comparing Germ-Free Mice and Antibiotics Treatment as Tools for Modifying Gut Bacteria. Front Physiol. 2018; 9:1534. PMID: 30429801.
      View in: PubMed
    7. Morales-Mantilla DE, King KY. The Role of Interferon-Gamma in Hematopoietic Stem Cell Development, Homeostasis, and Disease. Curr Stem Cell Rep. 2018; 4(3):264-271. PMID: 30148048.
      View in: PubMed
    8. Yan H, Baldridge MT, King KY. Hematopoiesis and the bacterial microbiome. Blood. 2018 08 09; 132(6):559-564. PMID: 29853538.
      View in: PubMed
    9. Kitagawa MG, Ettinger N, Breen D, Erklauer J, Chang E, Herce H, King K, Naik S. Transmission of West Nile Virus Through a Hematopoietic Stem Cell Transplant. J Pediatric Infect Dis Soc. 2018 May 15; 7(2):e52-e54. PMID: 29309636.
      View in: PubMed
    10. Tashi T, Swierczek S, Kim SJ, Salama ME, Song J, Heikal N, King KY, Hickman K, Litton S, Prchal JT. Pegylated interferon Alfa-2a and hydroxyurea in polycythemia vera and essential thrombocythemia: differential cellular and molecular responses. Leukemia. 2018 08; 32(8):1830-1833. PMID: 29556018.
      View in: PubMed
    11. Matatall KA, Kadmon CS, King KY. Detecting Hematopoietic Stem Cell Proliferation Using BrdU Incorporation. Methods Mol Biol. 2018; 1686:91-103. PMID: 29030815.
      View in: PubMed
    12. King KY. Saving Stem Cells after Stress. Cell Stem Cell. 2017 12 07; 21(6):709-710. PMID: 29220661.
      View in: PubMed
    13. Kadmon CS, Landers CT, Li HS, Watowich SS, Rodriguez A, King KY. MicroRNA-22 controls interferon alpha production and erythroid maturation in response to infectious stress in mice. Exp Hematol. 2017 12; 56:7-15. PMID: 28911907.
      View in: PubMed
    14. Matatall KA, Jeong M, Chen S, Sun D, Chen F, Mo Q, Kimmel M, King KY. Chronic Infection Depletes Hematopoietic Stem Cells through Stress-Induced Terminal Differentiation. Cell Rep. 2016 12 06; 17(10):2584-2595. PMID: 27926863.
      View in: PubMed
    15. Josefsdottir KS, Baldridge MT, Kadmon CS, King KY. Antibiotics impair murine hematopoiesis by depleting the intestinal microbiota. Blood. 2017 02 09; 129(6):729-739. PMID: 27879260.
      View in: PubMed
    16. Luis TC, Tremblay CS, Manz MG, North TE, King KY, Challen GA. Inflammatory signals in HSPC development and homeostasis: Too much of a good thing? Exp Hematol. 2016 10; 44(10):908-12. PMID: 27423816.
      View in: PubMed
    17. Li HS, Jin J, Liang X, Matatall KA, Ma Y, Zhang H, Ullrich SE, King KY, Sun SC, Watowich SS. Loss of c-Kit and bone marrow failure upon conditional removal of the GATA-2 C-terminal zinc finger domain in adult mice. Eur J Haematol. 2016 Sep; 97(3):261-70. PMID: 26660446.
      View in: PubMed
    18. King KY, Matatall KA, Shen CC, Goodell MA, Swierczek SI, Prchal JT. Comparative long-term effects of interferon a and hydroxyurea on human hematopoietic progenitor cells. Exp Hematol. 2015 Oct; 43(10):912-918.e2. PMID: 26072330.
      View in: PubMed
    19. King KY, Hicks MJ, Mazziotti MV, Eldin KW, Starke JR, Michael M. Persistent cat scratch disease requiring surgical excision in a patient with MPGN. Pediatrics. 2015 Jun; 135(6):e1514-7. PMID: 25963015.
      View in: PubMed
    20. Josefsdottir KS, King KY. Interferons coordinate a multifaceted defense. Cell Host Microbe. 2015 Jan 14; 17(1):6-7. PMID: 25590754.
      View in: PubMed
    21. Trompouki E, King KY, Will B, Lessard J, Flores-Figueroa E, Kokkaliaris KD, Bowman T. Bloody signals: from birth to disease and death. Exp Hematol. 2014 Dec; 42(12):989-94. PMID: 25482344.
      View in: PubMed
    22. Matatall KA, Shen CC, Challen GA, King KY. Type II interferon promotes differentiation of myeloid-biased hematopoietic stem cells. Stem Cells. 2014 Nov; 32(11):3023-30. PMID: 25078851.
      View in: PubMed
    23. Rodgers JT, King KY, Brett JO, Cromie MJ, Charville GW, Maguire KK, Brunson C, Mastey N, Liu L, Tsai CR, Goodell MA, Rando TA. mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert). Nature. 2014 Jun 19; 510(7505):393-6. PMID: 24870234.
      View in: PubMed
    24. Rossi L, Lin KK, Boles NC, Yang L, King KY, Jeong M, Mayle A, Goodell MA. Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice. Cell Stem Cell. 2012 Sep 07; 11(3):302-17. PMID: 22958929.
      View in: PubMed
    25. King KY, Goodell MA. Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response. Nat Rev Immunol. 2011 Sep 09; 11(10):685-92. PMID: 21904387.
      View in: PubMed
    26. King KY, Baldridge MT, Weksberg DC, Chambers SM, Lukov GL, Wu S, Boles NC, Jung SY, Qin J, Liu D, Songyang Z, Eissa NT, Taylor GA, Goodell MA. Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling. Blood. 2011 Aug 11; 118(6):1525-33. PMID: 21633090.
      View in: PubMed
    27. King KY, Goodell MA. Direct conversion of skin cells into blood: alchemy or science? Mol Ther. 2011 Feb; 19(2):227-8. PMID: 21289635.
      View in: PubMed
    28. King KY, Lew JD, Ha NP, Lin JS, Ma X, Graviss EA, Goodell MA. Polymorphic allele of human IRGM1 is associated with susceptibility to tuberculosis in African Americans. PLoS One. 2011 Jan 21; 6(1):e16317. PMID: 21283700.
      View in: PubMed
    29. Baldridge MT, King KY, Goodell MA. Inflammatory signals regulate hematopoietic stem cells. Trends Immunol. 2011 Feb; 32(2):57-65. PMID: 21233016.
      View in: PubMed
    30. Baldridge MT, King KY, Boles NC, Weksberg DC, Goodell MA. Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection. Nature. 2010 Jun 10; 465(7299):793-7. PMID: 20535209.
      View in: PubMed
    31. King KY, Edwards MS, Word BM. Hepatitis associated with micafungin use in a preterm infant. J Perinatol. 2009 Apr; 29(4):320-2. PMID: 19325554.
      View in: PubMed
    32. King K, Browning JC, Metry DW, Prestigiacomo J, Scollard D, Schutze GE, Stryjewska B, Schwarzwald H. Leprosy and international adoption: a case report and review of diagnostic and treatment dilemmas. Pediatr Infect Dis J. 2009 Apr; 28(4):322-5. PMID: 19238115.
      View in: PubMed
    33. Brenot A, King KY, Caparon MG. The PerR regulon in peroxide resistance and virulence of Streptococcus pyogenes. Mol Microbiol. 2005 Jan; 55(1):221-34. PMID: 15612930.
      View in: PubMed
    34. Brenot A, King KY, Janowiak B, Griffith O, Caparon MG. Contribution of glutathione peroxidase to the virulence of Streptococcus pyogenes. Infect Immun. 2004 Jan; 72(1):408-13. PMID: 14688122.
      View in: PubMed
    35. King KY, Horenstein JA, Caparon MG. Aerotolerance and peroxide resistance in peroxidase and PerR mutants of Streptococcus pyogenes. J Bacteriol. 2000 Oct; 182(19):5290-9. PMID: 10986229.
      View in: PubMed
    36. Worley KC, King KY, Chua S, McCabe ER, Smith RF. Identification of new members of a carbohydrate kinase-encoding gene family. J Comput Biol. 1995; 2(3):451-8. PMID: 8521274.
      View in: PubMed
    37. Smith RF, King KY. Identification of a eukaryotic-like protein kinase gene in Archaebacteria. Protein Sci. 1995 Jan; 4(1):126-9. PMID: 7773169.
      View in: PubMed
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