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KARL-DIMITER BISSIG

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentCenter for Cell & Gene Therapy
    DivisionCenter for Cell & Gene Therapy

    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Virology & Microbiology
    DivisionMolecular Virology & Microbiology


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    R01HL134510     (BISSIG, KARL-DIMITER)Jul 1, 2016 - Apr 30, 2021
    NIH/NHLBI
    Therapeutic potential of CRISPR/Cas9 genome engineering in humanized mouse models
    Role: Principal Investigator

    R56DK115461     (BISSIG, KARL-DIMITER)Sep 13, 2017 - Sep 12, 2018
    NIH/NIDDK
    Therapeutic pathway reprogramming for metabolic liver disease
    Role: Principal Investigator

    R01DK115461     (BISSIG, KARL-DIMITER)Sep 14, 2018 - Aug 31, 2021
    NIH/NIDDK
    Therapeutic pathway reprogramming for metabolic liver disease
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Pankowicz FP, Barzi M, Kim KH, Legras X, Martins CS, Wooton-Kee CR, Lagor WR, Marini JC, Elsea SH, Bissig-Choisat B, Moore DD, Bissig KD. Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing. Gastroenterology. 2018 12; 155(6):1967-1970.e6. PMID: 30170115.
      View in: PubMed
    2. Bissig KD, Han W, Barzi M, Kovalchuk N, Ding L, Fan X, Pankowicz FP, Zhang QY, Ding X. P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity. Drug Metab Dispos. 2018 11; 46(11):1734-1744. PMID: 30093418.
      View in: PubMed
    3. Kho J, Tian X, Wong WT, Bertin T, Jiang MM, Chen S, Jin Z, Shchelochkov OA, Burrage LC, Reddy AK, Jiang H, Abo-Zahrah R, Ma S, Zhang P, Bissig KD, Kim JJ, Devaraj S, Rodney GG, Erez A, Bryan NS, Nagamani SCS, Lee BH. Argininosuccinate Lyase Deficiency Causes an Endothelial-Dependent Form of Hypertension. Am J Hum Genet. 2018 08 02; 103(2):276-287. PMID: 30075114.
      View in: PubMed
    4. Valanejad L, Cast A, Wright M, Bissig KD, Karns R, Weirauch MT, Timchenko N. PARP1 activation increases expression of modified tumor suppressors and pathways underlying development of aggressive hepatoblastoma. Commun Biol. 2018; 1:67. PMID: 30271949.
      View in: PubMed
    5. Kruse RL, Shum T, Tashiro H, Barzi M, Yi Z, Whitten-Bauer C, Legras X, Bissig-Choisat B, Garaigorta U, Gottschalk S, Bissig KD. HBsAg-redirected T cells exhibit antiviral activity in HBV-infected human liver chimeric mice. Cytotherapy. 2018 05; 20(5):697-705. PMID: 29631939.
      View in: PubMed
    6. Woodfield SE, Shi Y, Patel RH, Jin J, Major A, Sarabia SF, Starosolski Z, Zorman B, Gupta SS, Chen Z, Ibarra AM, Bissig KD, Ghaghada KB, Sumazin P, López-Terrada D, Vasudevan SA. A Novel Cell Line Based Orthotopic Xenograft Mouse Model That Recapitulates Human Hepatoblastoma. Sci Rep. 2017 12 19; 7(1):17751. PMID: 29259231.
      View in: PubMed
    7. Barzi M, Pankowicz FP, Zorman B, Liu X, Legras X, Yang D, Borowiak M, Bissig-Choisat B, Sumazin P, Li F, Bissig KD. Erratum: A novel humanized mouse lacking murine p450 oxidoreductase for studying human drug metabolism. Nat Commun. 2017 10 17; 8(1):984. PMID: 29042563.
      View in: PubMed
    8. Kruse RL, Shum T, Legras X, Barzi M, Pankowicz FP, Gottschalk S, Bissig KD. In Situ Liver Expression of HBsAg/CD3-Bispecific Antibodies for HBV Immunotherapy. Mol Ther Methods Clin Dev. 2017 Dec 15; 7:32-41. PMID: 29018834.
      View in: PubMed
    9. Barzi M, Pankowicz FP, Zorman B, Liu X, Legras X, Yang D, Borowiak M, Bissig-Choisat B, Sumazin P, Li F, Bissig KD. A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism. Nat Commun. 2017 06 28; 8(1):39. PMID: 28659616.
      View in: PubMed
    10. Velasquez-Mao AJ, Tsao CJM, Monroe MN, Legras X, Bissig-Choisat B, Bissig KD, Ruano R, Jacot JG. Differentiation of spontaneously contracting cardiomyocytes from non-virally reprogrammed human amniotic fluid stem cells. PLoS One. 2017; 12(5):e0177824. PMID: 28545044.
      View in: PubMed
    11. Pankowicz FP, Jarrett KE, Lagor WR, Bissig KD. CRISPR/Cas9: at the cutting edge of hepatology. Gut. 2017 07; 66(7):1329-1340. PMID: 28487442.
      View in: PubMed
    12. Jarrett KE, Lee CM, Yeh YH, Hsu RH, Gupta R, Zhang M, Rodriguez PJ, Lee CS, Gillard BK, Bissig KD, Pownall HJ, Martin JF, Bao G, Lagor WR. Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease. Sci Rep. 2017 03 16; 7:44624. PMID: 28300165.
      View in: PubMed
    13. Pankowicz FP, Barzi M, Legras X, Hubert L, Mi T, Tomolonis JA, Ravishankar M, Sun Q, Yang D, Borowiak M, Sumazin P, Elsea SH, Bissig-Choisat B, Bissig KD. Reprogramming metabolic pathways in vivo with CRISPR/Cas9 genome editing to treat hereditary tyrosinaemia. Nat Commun. 2016 08 30; 7:12642. PMID: 27572891.
      View in: PubMed
    14. Bissig KD, Paust S, Barzi M. Liver is liver and blood is blood, and finally the twain have met. J Hepatol. 2016 08; 65(2):245-8. PMID: 27221221.
      View in: PubMed
    15. Bissig-Choisat B, Kettlun-Leyton C, Legras XD, Zorman B, Barzi M, Chen LL, Amin MD, Huang YH, Pautler RG, Hampton OA, Prakash MM, Yang D, Borowiak M, Muzny D, Doddapaneni HV, Hu J, Shi Y, Gaber MW, Hicks MJ, Thompson PA, Lu Y, Mills GB, Finegold M, Goss JA, Parsons DW, Vasudevan SA, Sumazin P, López-Terrada D, Bissig KD. Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer. J Hepatol. 2016 08; 65(2):325-33. PMID: 27117591.
      View in: PubMed
    16. Billioud G, Kruse RL, Carrillo M, Whitten-Bauer C, Gao D, Kim A, Chen L, McCaleb ML, Crosby JR, Hamatake R, Hong Z, Garaigorta U, Swayze E, Bissig KD, Wieland S. In vivo reduction of hepatitis B virus antigenemia and viremia by antisense oligonucleotides. J Hepatol. 2016 Apr; 64(4):781-9. PMID: 26658683.
      View in: PubMed
    17. Shih YM, Sun CP, Chou HH, Wu TH, Chen CC, Wu PY, Enya Chen YC, Bissig KD, Tao MH. Combinatorial RNA Interference Therapy Prevents Selection of Pre-existing HBV Variants in Human Liver Chimeric Mice. Sci Rep. 2015 Oct 20; 5:15259. PMID: 26482836.
      View in: PubMed
    18. Bissig-Choisat B, Wang L, Legras X, Saha PK, Chen L, Bell P, Pankowicz FP, Hill MC, Barzi M, Leyton CK, Leung HE, Kruse RL, Himes RW, Goss JA, Wilson JM, Chan L, Lagor WR, Bissig KD. Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model. Nat Commun. 2015 Jun 17; 6:7339. PMID: 26081744.
      View in: PubMed
    19. Lin F, Marcelo KL, Rajapakshe K, Coarfa C, Dean A, Wilganowski N, Robinson H, Sevick E, Bissig KD, Goldie LC, Means AR, York B. The camKK2/camKIV relay is an essential regulator of hepatic cancer. Hepatology. 2015 Aug; 62(2):505-20. PMID: 25847065.
      View in: PubMed
    20. Bissig KD, Grompe M. Response to "Can 'humanized' mice improve drug development in the 21st century?". Trends Pharmacol Sci. 2013 Aug; 34(8):425. PMID: 23876405.
      View in: PubMed
    21. Goldman O, Han S, Sourisseau M, Sourrisseau M, Dziedzic N, Hamou W, Corneo B, D'Souza S, Sato T, Kotton DN, Bissig KD, Kalir T, Jacobs A, Evans T, Evans MJ, Gouon-Evans V. KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development. Cell Stem Cell. 2013 Jun 06; 12(6):748-60. PMID: 23746980.
      View in: PubMed
    22. Ruiz S, Panopoulos AD, Herrerías A, Bissig KD, Lutz M, Berggren WT, Verma IM, Izpisua Belmonte JC. A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity. Curr Biol. 2011 Jan 11; 21(1):45-52. PMID: 21167714.
      View in: PubMed
    23. Bissig KD, Wieland SF, Tran P, Isogawa M, Le TT, Chisari FV, Verma IM. Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment. J Clin Invest. 2010 Mar; 120(3):924-30. PMID: 20179355.
      View in: PubMed
    24. Bissig KD, Le TT, Woods NB, Verma IM. Repopulation of adult and neonatal mice with human hepatocytes: a chimeric animal model. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20507-11. PMID: 18077355.
      View in: PubMed
    25. Bissig KD, Honer M, Zimmermann K, Summer KH, Solioz M. Whole animal copper flux assessed by positron emission tomography in the Long-Evans cinnamon rat--a feasibility study. Biometals. 2005 Feb; 18(1):83-8. PMID: 15865413.
      View in: PubMed
    26. Bissig KD, Zimmermann A, Bernasch D, Furrer H, Dufour JF. Herpes simplex virus hepatitis 4 years after liver transplantation. J Gastroenterol. 2003; 38(10):1005-8. PMID: 14614611.
      View in: PubMed
    27. Bissig KD, Voegelin TC, Solioz M. Tetrathiomolybdate inhibition of the Enterococcus hirae CopB copper ATPase. FEBS Lett. 2001 Nov 02; 507(3):367-70. PMID: 11696373.
      View in: PubMed
    28. Multhaup G, Strausak D, Bissig KD, Solioz M. Interaction of the CopZ copper chaperone with the CopA copper ATPase of Enterococcus hirae assessed by surface plasmon resonance. Biochem Biophys Res Commun. 2001 Oct 19; 288(1):172-7. PMID: 11594769.
      View in: PubMed
    29. Bissig KD, Wunderli-Ye H, Duda PW, Solioz M. Structure-function analysis of purified Enterococcus hirae CopB copper ATPase: effect of Menkes/Wilson disease mutation homologues. Biochem J. 2001 Jul 01; 357(Pt 1):217-23. PMID: 11415452.
      View in: PubMed
    30. Bissig KD, La Fontaine S, Mercer JF, Solioz M. Expression of the human Menkes ATPase in Xenopus laevis oocytes. Biol Chem. 2001 Apr; 382(4):711-4. PMID: 11405236.
      View in: PubMed
    31. Bissig KD, Marti U, Solioz M, Forestier M, Zimmermann H, Lüthi M, Reichen J. Epidermal growth factor is decreased in liver of rats with biliary cirrhosis but does not act as paracrine growth factor immediately after hepatectomy. J Hepatol. 2000 Aug; 33(2):275-81. PMID: 10952245.
      View in: PubMed
    32. Solioz M, Bissig KD. [How (deficient) copper causes illness]. Schweiz Med Wochenschr. 1998 Aug 04; 128(31-32):1175-80. PMID: 9738276.
      View in: PubMed
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