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KAREN K HIRSCHI

TitleAdjunct Professor
InstitutionBaylor College of Medicine
DepartmentCenter for Cell & Gene Therapy
DivisionCenter for Cell & Gene Therapy
AddressONE BAYLOR PLAZA
PEDIATRICS - NUTRITION
HOUSTON TX 77030
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    Other Positions
    TitleAdjunct Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

    TitleAdjunct Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Physiology & Biophysics
    DivisionMolecular Physiology & Biophysics

    TitleAdjunct Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pediatrics
    DivisionPediatrics-Nutrition


    Collapse Research 
    Collapse research activities and funding
    F32HL009037     (HIRSCHI, KAREN K)Aug 27, 1994
    NIH/NHLBI
    SMOOTH MUSCLE CELL RECRUITMENT AND DIFFERENTIATION
    Role: Principal Investigator

    R01HL061408     (HIRSCHI, KAREN K)May 1, 2000 - Apr 30, 2006
    NIH/NHLBI
    RETINOID REGULATION OF BLOOD VESSEL FORMATION
    Role: Principal Investigator

    R01HL076260     (HIRSCHI, KAREN K)Apr 1, 2004 - Mar 31, 2009
    NIH/NHLBI
    Developmental Defects in Blood and Vessel Formation
    Role: Principal Investigator

    R01HL077675     (HIRSCHI, KAREN K)Jul 1, 2004 - May 31, 2013
    NIH/NHLBI
    Role of Gap Junctions in Blood Vessel Assembly
    Role: Principal Investigator

    R01EB005173     (HIRSCHI, KAREN K)Sep 30, 2005 - Aug 31, 2011
    NIH/NIBIB
    Tissue Engineering of Hematopoietic Bone
    Role: Principal Investigator

    P20EB007076     (HIRSCHI, KAREN K)Sep 25, 2006 - Aug 31, 2010
    NIH/NIBIB
    Neuro-Vascular Regeneration
    Role: Principal Investigator

    R01HL096360     (HIRSCHI, KAREN K)Apr 1, 2009 - Nov 30, 2014
    NIH/NHLBI
    Human Endothelial Cell Differentiation
    Role: Principal Investigator

    R13HL115803     (HIRSCHI, KAREN K)Jul 7, 2012 - Jun 30, 2013
    NIH/NHLBI
    2012 Signal Transduction By Engineered Extracellular Matrices Gordon Research Con
    Role: Principal Investigator

    R01EB016629     (HIRSCHI, KAREN K)Jan 15, 2014 - Dec 31, 2018
    NIH/NIBIB
    Neurovascualar Regeneration
    Role: Principal Investigator

    R01HL128064     (HIRSCHI, KAREN K)Apr 1, 2015 - Feb 28, 2019
    NIH/NHLBI
    Specification of Hemogenic Endothelial Cells
    Role: Principal Investigator

    R13HL142339     (HIRSCHI, KAREN K)Jun 1, 2018 - May 30, 2019
    NIH/NHLBI
    2018 Endothelial Cell Phenotypes in Health and Disease Gordon Research Conference and Gordon Research Seminar
    Role: Principal Investigator

    R56DK118728     (NICOLI, STEFANIA)Aug 1, 2018 - Jul 31, 2019
    NIH/NIDDK
    miR-223 regulates endothelial to hematopoietic transition
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hirschi KK, Dejana E. Resident Endothelial Progenitors Make Themselves at Home. Cell Stem Cell. 2018 Aug 02; 23(2):153-155. PMID: 30075124.
      View in: PubMed
    2. Genet N, Bhatt N, Bourdieu A, Hirschi KK. Multifaceted Roles of Connexin 43 in Stem Cell Niches. Curr Stem Cell Rep. 2018; 4(1):1-12. PMID: 29600160.
      View in: PubMed
    3. Fang JS, Coon BG, Gillis N, Chen Z, Qiu J, Chittenden TW, Burt JM, Schwartz MA, Hirschi KK. Addendum: Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification. Nat Commun. 2018 02 14; 9(1):720. PMID: 29445140.
      View in: PubMed
    4. Fang JS, Coon BG, Gillis N, Chen Z, Qiu J, Chittenden TW, Burt JM, Schwartz MA, Hirschi KK. Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification. Nat Commun. 2017 12 15; 8(1):2149. PMID: 29247167.
      View in: PubMed
    5. Polacheck WJ, Kutys ML, Yang J, Eyckmans J, Wu Y, Vasavada H, Hirschi KK, Chen CS. A non-canonical Notch complex regulates adherens junctions and vascular barrier function. Nature. 2017 12 14; 552(7684):258-262. PMID: 29160307.
      View in: PubMed
    6. Sivarapatna A, Ghaedi M, Xiao Y, Han E, Aryal B, Zhou J, Fernandez-Hernando C, Qyang Y, Hirschi KK, Niklason LE. Engineered Microvasculature in PDMS Networks Using Endothelial Cells Derived from Human Induced Pluripotent Stem Cells. Cell Transplant. 2017 08; 26(8):1365-1379. PMID: 28901188.
      View in: PubMed
    7. Yu P, Wilhelm K, Dubrac A, Tung JK, Alves TC, Fang JS, Xie Y, Zhu J, Chen Z, De Smet F, Zhang J, Jin SW, Sun L, Sun H, Kibbey RG, Hirschi KK, Hay N, Carmeliet P, Chittenden TW, Eichmann A, Potente M, Simons M. FGF-dependent metabolic control of vascular development. Nature. 2017 05 11; 545(7653):224-228. PMID: 28467822.
      View in: PubMed
    8. Hirschi KK, Nicoli S, Walsh K. Hematopoiesis Lineage Tree Uprooted: Every Cell Is a Rainbow. Dev Cell. 2017 04 10; 41(1):7-9. PMID: 28399402.
      View in: PubMed
    9. Dejana E, Hirschi KK, Simons M. The molecular basis of endothelial cell plasticity. Nat Commun. 2017 02 09; 8:14361. PMID: 28181491.
      View in: PubMed
    10. Fuster JJ, MacLauchlan S, Zuriaga MA, Polackal MN, Ostriker AC, Chakraborty R, Wu CL, Sano S, Muralidharan S, Rius C, Vuong J, Jacob S, Muralidhar V, Robertson AA, Cooper MA, Andrés V, Hirschi KK, Martin KA, Walsh K. Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice. Science. 2017 02 24; 355(6327):842-847. PMID: 28104796.
      View in: PubMed
    11. Ola R, Dubrac A, Han J, Zhang F, Fang JS, Larrivée B, Lee M, Urarte AA, Kraehling JR, Genet G, Hirschi KK, Sessa WC, Canals FV, Graupera M, Yan M, Young LH, Oh PS, Eichmann A. PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia. Nat Commun. 2016 11 29; 7:13650. PMID: 27897192.
      View in: PubMed
    12. Ceneri N, Zhao L, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi MM, Bender JR, Morrison AR. Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1ß Production. Arterioscler Thromb Vasc Biol. 2017 Feb; 37(2):328-340. PMID: 27834690.
      View in: PubMed
    13. Wang Y, Baeyens N, Corti F, Tanaka K, Fang JS, Zhang J, Jin Y, Coon B, Hirschi KK, Schwartz MA, Simons M. Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development. Development. 2016 12 01; 143(23):4441-4451. PMID: 27789626.
      View in: PubMed
    14. Fang JS, Gritz EC, Marcelo KL, Hirschi KK. Isolation of Murine Embryonic Hemogenic Endothelial Cells. J Vis Exp. 2016 06 17; (112). PMID: 27341393.
      View in: PubMed
    15. Goligorsky MS, Hirschi K. Stress-Induced Premature Senescence of Endothelial and Endothelial Progenitor Cells. Adv Pharmacol. 2016; 77:281-306. PMID: 27451101.
      View in: PubMed
    16. Gritz E, Hirschi KK. Specification and function of hemogenic endothelium during embryogenesis. Cell Mol Life Sci. 2016 Apr; 73(8):1547-67. PMID: 26849156; PMCID: PMC4805691.
    17. Muralidharan S, Sasi SP, Zuriaga MA, Hirschi KK, Porada CD, Coleman MA, Walsh KX, Yan X, Goukassian DA. Corrigendum: Ionizing Particle Radiation as a Modulator of Endogenous Bone Marrow Cell Reprogramming: Implications for Hematological Cancers. Front Oncol. 2015; 5:255. PMID: 26636037; PMCID: PMC4658418.
    18. Cuchiara ML, Coskun S, Banda OA, Horter KL, Hirschi KK, West JL. Bioactive poly(ethylene glycol) hydrogels to recapitulate the HSC niche and facilitate HSC expansion in culture. Biotechnol Bioeng. 2016 Apr; 113(4):870-81. PMID: 26497172.
      View in: PubMed
    19. Muralidharan S, Sasi SP, Zuriaga MA, Hirschi KK, Porada CD, Coleman MA, Walsh KX, Yan X, Goukassian DA. Ionizing Particle Radiation as a Modulator of Endogenous Bone Marrow Cell Reprogramming: Implications for Hematological Cancers. Front Oncol. 2015; 5:231. PMID: 26528440; PMCID: PMC4604322.
    20. Martin KA, Hirschi KK. The magic touch: endothelial cells muscle-up adipose. Circ Res. 2014 Oct 10; 115(9):752-4. PMID: 25301822; PMCID: PMC4269234.
    21. Coskun S, Chao H, Vasavada H, Heydari K, Gonzales N, Zhou X, de Crombrugghe B, Hirschi KK. Development of the fetal bone marrow niche and regulation of HSC quiescence and homing ability by emerging osteolineage cells. Cell Rep. 2014 Oct 23; 9(2):581-90. PMID: 25310984; PMCID: PMC4266564.
    22. Hirschi KK, Li S, Roy K. Induced pluripotent stem cells for regenerative medicine. Annu Rev Biomed Eng. 2014 Jul 11; 16:277-94. PMID: 24905879; PMCID: PMC4287204.
    23. Vunjak-Novakovic G, Bhatia S, Chen C, Hirschi K. HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease. Stem Cell Res Ther. 2013; 4 Suppl 1:S8. PMID: 24565063; PMCID: PMC4029174.
    24. Marcelo KL, Sills TM, Coskun S, Vasavada H, Sanglikar S, Goldie LC, Hirschi KK. Hemogenic endothelial cell specification requires c-Kit, Notch signaling, and p27-mediated cell-cycle control. Dev Cell. 2013 Dec 09; 27(5):504-15. PMID: 24331925; PMCID: PMC3994666.
    25. Marcelo KL, Goldie LC, Hirschi KK. Regulation of endothelial cell differentiation and specification. Circ Res. 2013 Apr 26; 112(9):1272-87. PMID: 23620236; PMCID: PMC3768127.
    26. Goldberg JS, Vadakkan TJ, Hirschi KK, Dickinson ME. A computational approach to detect gap junction plaques and associate them with cells in fluorescent images. J Histochem Cytochem. 2013 Apr; 61(4):283-93. PMID: 23324867; PMCID: PMC3636683.
    27. Fang JS, Dai C, Kurjiaka DT, Burt JM, Hirschi KK. Connexin45 regulates endothelial-induced mesenchymal cell differentiation toward a mural cell phenotype. Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2):362-8. PMID: 23220276; PMCID: PMC3737426.
    28. Agrawal V, Siu BF, Chao H, Hirschi KK, Raborn E, Johnson SA, Tottey S, Hurley KB, Medberry CJ, Badylak SF. Partial characterization of the Sox2+ cell population in an adult murine model of digit amputation. Tissue Eng Part A. 2012 Jul; 18(13-14):1454-63. PMID: 22530556; PMCID: PMC3397117.
    29. Hirschi KK. Hemogenic endothelium during development and beyond. Blood. 2012 May 24; 119(21):4823-7. PMID: 22415753; PMCID: PMC3367889.
    30. Suire C, Brouard N, Hirschi K, Simmons PJ. Isolation of the stromal-vascular fraction of mouse bone marrow markedly enhances the yield of clonogenic stromal progenitors. Blood. 2012 Mar 15; 119(11):e86-95. PMID: 22262767; PMCID: PMC4507041.
    31. Kienstra KA, Hirschi KK. Vascular progenitor cell mobilization. Methods Mol Biol. 2012; 904:155-64. PMID: 22890930.
      View in: PubMed
    32. Kienstra KA, Hirschi KK. Studying vascular progenitor cells in a neonatal mouse model. Methods Mol Biol. 2012; 904:235-42. PMID: 22890936.
      View in: PubMed
    33. Chaudhury H, Goldie LC, Hirschi KK. Vascular precursor cells. Genes Cancer. 2011 Dec; 2(12):1081-4. PMID: 22866199; PMCID: PMC3411132.
    34. Chaudhury H, Raborn E, Goldie LC, Hirschi KK. Stem cell-derived vascular endothelial cells and their potential application in regenerative medicine. Cells Tissues Organs. 2012; 195(1-2):41-7. PMID: 22005724.
      View in: PubMed
    35. Badylak SF, Hirschi KK, Niklason LE. Cardiovascular regenerative biology. Cells Tissues Organs. 2012; 195(1-2):4. PMID: 22179179; PMCID: PMC3697875.
    36. Salsman VS, Chow KK, Shaffer DR, Kadikoy H, Li XN, Gerken C, Perlaky L, Metelitsa LS, Gao X, Bhattacharjee M, Hirschi K, Heslop HE, Gottschalk S, Ahmed N. Crosstalk between medulloblastoma cells and endothelium triggers a strong chemotactic signal recruiting T lymphocytes to the tumor microenvironment. PLoS One. 2011; 6(5):e20267. PMID: 21647415; PMCID: PMC3103535.
    37. Sivina M, Yamada T, Park CS, Puppi M, Coskun S, Hirschi K, Lacorazza HD. The transcription factor E74-like factor controls quiescence of endothelial cells and their resistance to myeloablative treatments in bone marrow. Arterioscler Thromb Vasc Biol. 2011 May; 31(5):1185-91. PMID: 21350194; PMCID: PMC3100289.
    38. Coskun S, Hirschi KK. Establishment and regulation of the HSC niche: Roles of osteoblastic and vascular compartments. Birth Defects Res C Embryo Today. 2010 Dec; 90(4):229-42. PMID: 21181885.
      View in: PubMed
    39. Abbas HA, Maccio DR, Coskun S, Jackson JG, Hazen AL, Sills TM, You MJ, Hirschi KK, Lozano G. Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity. Cell Stem Cell. 2010 Nov 05; 7(5):606-17. PMID: 21040902; PMCID: PMC3026610.
    40. Enciso JM, Konecny CM, Karpen HE, Hirschi KK. Endothelial cell migration during murine yolk sac vascular remodeling occurs by means of a Rac1 and FAK activation pathway in vivo. Dev Dyn. 2010 Oct; 239(10):2570-83. PMID: 20737513; PMCID: PMC2967657.
    41. Kazanis I, Lathia JD, Vadakkan TJ, Raborn E, Wan R, Mughal MR, Eckley DM, Sasaki T, Patton B, Mattson MP, Hirschi KK, Dickinson ME, ffrench-Constant C. Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals. J Neurosci. 2010 Jul 21; 30(29):9771-81. PMID: 20660259; PMCID: PMC3842479.
    42. Armstrong JJ, Larina IV, Dickinson ME, Zimmer WE, Hirschi KK. Characterization of bacterial artificial chromosome transgenic mice expressing mCherry fluorescent protein substituted for the murine smooth muscle alpha-actin gene. Genesis. 2010 Jul; 48(7):457-63. PMID: 20506352; PMCID: PMC2906650.
    43. Iacobas I, Vats A, Hirschi KK. Vascular potential of human pluripotent stem cells. Arterioscler Thromb Vasc Biol. 2010 Jun; 30(6):1110-7. PMID: 20453170; PMCID: PMC2896478.
    44. Hirschi KK. Vascular precursors: origin, regulation and function. Arterioscler Thromb Vasc Biol. 2010 Jun; 30(6):1078-9. PMID: 20453165.
      View in: PubMed
    45. Dilling CF, Wada AM, Lazard ZW, Salisbury EA, Gannon FH, Vadakkan TJ, Gao L, Hirschi K, Dickinson ME, Davis AR, Olmsted-Davis EA. Vessel formation is induced prior to the appearance of cartilage in BMP-2-mediated heterotopic ossification. J Bone Miner Res. 2010 May; 25(5):1147-56. PMID: 19839764; PMCID: PMC3153372.
    46. Chao H, Hirschi KK. Hemato-vascular origins of endothelial progenitor cells? Microvasc Res. 2010 May; 79(3):169-73. PMID: 20149806; PMCID: PMC2857563.
    47. Justice MJ, Hirschi KK. The role of quaking in mammalian embryonic development. Adv Exp Med Biol. 2010; 693:82-92. PMID: 21189687.
      View in: PubMed
    48. Boles MK, Wilkinson BM, Wilming LG, Liu B, Probst FJ, Harrow J, Grafham D, Hentges KE, Woodward LP, Maxwell A, Mitchell K, Risley MD, Johnson R, Hirschi K, Lupski JR, Funato Y, Miki H, Marin-Garcia P, Matthews L, Coffey AJ, Parker A, Hubbard TJ, Rogers J, Bradley A, Adams DJ, Justice MJ. Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin. PLoS Genet. 2009 Dec; 5(12):e1000759. PMID: 20011118.
      View in: PubMed
    49. Agrawal V, Johnson SA, Reing J, Zhang L, Tottey S, Wang G, Hirschi KK, Braunhut S, Gudas LJ, Badylak SF. Epimorphic regeneration approach to tissue replacement in adult mammals. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3351-5. PMID: 19966310; PMCID: PMC2840465.
    50. Goldberg JS, Hirschi KK. Diverse roles of the vasculature within the neural stem cell niche. Regen Med. 2009 Nov; 4(6):879-97. PMID: 19903006; PMCID: PMC2836203.
    51. Boles MK, Wilkinson BM, Maxwell A, Lai L, Mills AA, Nishijima I, Salinger AP, Moskowitz I, Hirschi KK, Liu B, Bradley A, Justice MJ. A mouse chromosome 4 balancer ENU-mutagenesis screen isolates eleven lethal lines. BMC Genet. 2009 Mar 06; 10:12. PMID: 19267930.
      View in: PubMed
    52. Kelly MA, Hirschi KK. Signaling hierarchy regulating human endothelial cell development. Arterioscler Thromb Vasc Biol. 2009 May; 29(5):718-24. PMID: 19213939; PMCID: PMC2729243.
    53. Goldie LC, Nix MK, Hirschi KK. Embryonic vasculogenesis and hematopoietic specification. Organogenesis. 2008 Oct; 4(4):257-63. PMID: 19337406; PMCID: PMC2634331.
    54. Goldie LC, Lucitti JL, Dickinson ME, Hirschi KK. Cell signaling directing the formation and function of hemogenic endothelium during murine embryogenesis. Blood. 2008 Oct 15; 112(8):3194-204. PMID: 18684862; PMCID: PMC2569173.
    55. Hirschi KK, Ingram DA, Yoder MC. Assessing identity, phenotype, and fate of endothelial progenitor cells. Arterioscler Thromb Vasc Biol. 2008 Sep; 28(9):1584-95. PMID: 18669889.
      View in: PubMed
    56. Kienstra KA, Jackson KA, Hirschi KK. Injury mechanism dictates contribution of bone marrow-derived cells to murine hepatic vascular regeneration. Pediatr Res. 2008 Feb; 63(2):131-6. PMID: 18043513.
      View in: PubMed
    57. Kienstra KA, Freysdottir D, Gonzales NM, Hirschi KK. Murine neonatal intravascular injections: modeling newborn disease. J Am Assoc Lab Anim Sci. 2007 Nov; 46(6):50-4. PMID: 17994673.
      View in: PubMed
    58. Enciso JM, Hirschi KK. Nutrient regulation of tumor and vascular endothelial cell proliferation. Curr Cancer Drug Targets. 2007 Aug; 7(5):432-7. PMID: 17691902.
      View in: PubMed
    59. Adams KE, Ke S, Kwon S, Liang F, Fan Z, Lu Y, Hirschi K, Mawad ME, Barry MA, Sevick-Muraca EM. Comparison of visible and near-infrared wavelength-excitable fluorescent dyes for molecular imaging of cancer. J Biomed Opt. 2007 Mar-Apr; 12(2):024017. PMID: 17477732.
      View in: PubMed
    60. Saunders WB, Bohnsack BL, Faske JB, Anthis NJ, Bayless KJ, Hirschi KK, Davis GE. Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3. J Cell Biol. 2006 Oct 09; 175(1):179-91. PMID: 17030988; PMCID: PMC2064509.
    61. Bohnsack BL, Lai L, Northrop JL, Justice MJ, Hirschi KK. Visceral endoderm function is regulated by quaking and required for vascular development. Genesis. 2006 Feb; 44(2):93-104. PMID: 16470614.
      View in: PubMed
    62. Enciso JM, Hirschi KK. Understanding abnormalities in vascular specification and remodeling. Pediatrics. 2005 Jul; 116(1):228-30. PMID: 15995057.
      View in: PubMed
    63. Bohnsack BL, Hirschi KK. Red light, green light: signals that control endothelial cell proliferation during embryonic vascular development. Cell Cycle. 2004 Dec; 3(12):1506-11. PMID: 15611620.
      View in: PubMed
    64. Huss WJ, Lai L, Barrios RJ, Hirschi KK, Greenberg NM. Retinoic acid slows progression and promotes apoptosis of spontaneous prostate cancer. Prostate. 2004 Oct 01; 61(2):142-52. PMID: 15305337.
      View in: PubMed
    65. Bohnsack BL, Lai L, Dolle P, Hirschi KK. Signaling hierarchy downstream of retinoic acid that independently regulates vascular remodeling and endothelial cell proliferation. Genes Dev. 2004 Jun 01; 18(11):1345-58. PMID: 15175265; PMCID: PMC420359.
    66. Bohnsack BL, Hirschi KK. Nutrient regulation of cell cycle progression. Annu Rev Nutr. 2004; 24:433-53. PMID: 15189127.
      View in: PubMed
    67. Hirschi KK, Majesky MW. Smooth muscle stem cells. Anat Rec A Discov Mol Cell Evol Biol. 2004 Jan; 276(1):22-33. PMID: 14699631.
      View in: PubMed
    68. Olmsted-Davis EA, Gugala Z, Camargo F, Gannon FH, Jackson K, Kienstra KA, Shine HD, Lindsey RW, Hirschi KK, Goodell MA, Brenner MK, Davis AR. Primitive adult hematopoietic stem cells can function as osteoblast precursors. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15877-82. PMID: 14673088; PMCID: PMC307661.
    69. Abramowitz J, Dai C, Hirschi KK, Dmitrieva RI, Doris PA, Liu L, Allen JC. Ouabain- and marinobufagenin-induced proliferation of human umbilical vein smooth muscle cells and a rat vascular smooth muscle cell line, A7r5. Circulation. 2003 Dec 16; 108(24):3048-53. PMID: 14638550.
      View in: PubMed
    70. Lai L, Bohnsack BL, Niederreither K, Hirschi KK. Retinoic acid regulates endothelial cell proliferation during vasculogenesis. Development. 2003 Dec; 130(26):6465-74. PMID: 14627725.
      View in: PubMed
    71. McKinney-Freeman SL, Majka SM, Jackson KA, Norwood K, Hirschi KK, Goodell MA. Altered phenotype and reduced function of muscle-derived hematopoietic stem cells. Exp Hematol. 2003 Sep; 31(9):806-14. PMID: 12962727.
      View in: PubMed
    72. Hirschi KK, Burt JM, Hirschi KD, Dai C. Gap junction communication mediates transforming growth factor-beta activation and endothelial-induced mural cell differentiation. Circ Res. 2003 Sep 05; 93(5):429-37. PMID: 12919949.
      View in: PubMed
    73. Nadin BM, Goodell MA, Hirschi KK. Phenotype and hematopoietic potential of side population cells throughout embryonic development. Blood. 2003 Oct 01; 102(7):2436-43. PMID: 12805065.
      View in: PubMed
    74. Bohnsack BL, Hirschi KK. The FAKs about blood vessel assembly. Circ Res. 2003 Feb 21; 92(3):255-7. PMID: 12595334.
      View in: PubMed
    75. Majka SM, Jackson KA, Kienstra KA, Majesky MW, Goodell MA, Hirschi KK. Distinct progenitor populations in skeletal muscle are bone marrow derived and exhibit different cell fates during vascular regeneration. J Clin Invest. 2003 Jan; 111(1):71-9. PMID: 12511590; PMCID: PMC151835.
    76. Hirschi KK, Skalak TC, Peirce SM, Little CD. Vascular assembly in natural and engineered tissues. Ann N Y Acad Sci. 2002 Jun; 961:223-42. PMID: 12081906.
      View in: PubMed
    77. Skalak TC, Little CD, McIntire LV, Hirschi KK, Tranquillo R, Post M, Ranieri J. Vascular assembly in engineered and natural tissues: breakout session summary. Ann N Y Acad Sci. 2002 Jun; 961:255-7. PMID: 12081911.
      View in: PubMed
    78. Hirschi KK, Goodell MA. Hematopoietic, vascular and cardiac fates of bone marrow-derived stem cells. Gene Ther. 2002 May; 9(10):648-52. PMID: 12032711.
      View in: PubMed
    79. Noveroske JK, Lai L, Gaussin V, Northrop JL, Nakamura H, Hirschi KK, Justice MJ. Quaking is essential for blood vessel development. Genesis. 2002 Mar; 32(3):218-30. PMID: 11892011.
      View in: PubMed
    80. Hirschi KK, Lai L, Belaguli NS, Dean DA, Schwartz RJ, Zimmer WE. Transforming growth factor-beta induction of smooth muscle cell phenotpye requires transcriptional and post-transcriptional control of serum response factor. J Biol Chem. 2002 Feb 22; 277(8):6287-95. PMID: 11741973; PMCID: PMC4421896.
    81. Hirschi K, Goodell M. Common origins of blood and blood vessels in adults? Differentiation. 2001 Oct; 68(4-5):186-92. PMID: 11776471.
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    82. Shigaki T, Cheng NH, Pittman JK, Hirschi K. Structural determinants of Ca2+ transport in the Arabidopsis H+/Ca2+ antiporter CAX1. J Biol Chem. 2001 Nov 16; 276(46):43152-9. PMID: 11562366.
      View in: PubMed
    83. Mäser P, Thomine S, Schroeder JI, Ward JM, Hirschi K, Sze H, Talke IN, Amtmann A, Maathuis FJ, Sanders D, Harper JF, Tchieu J, Gribskov M, Persans MW, Salt DE, Kim SA, Guerinot ML. Phylogenetic relationships within cation transporter families of Arabidopsis. Plant Physiol. 2001 Aug; 126(4):1646-67. PMID: 11500563; PMCID: PMC117164.
    84. Goodell MA, Jackson KA, Majka SM, Mi T, Wang H, Pocius J, Hartley CJ, Majesky MW, Entman ML, Michael LH, Hirschi KK. Stem cell plasticity in muscle and bone marrow. Ann N Y Acad Sci. 2001 Jun; 938:208-18; discussion 218-20. PMID: 11458510.
      View in: PubMed
    85. Jackson KA, Majka SM, Wang H, Pocius J, Hartley CJ, Majesky MW, Entman ML, Michael LH, Hirschi KK, Goodell MA. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest. 2001 Jun; 107(11):1395-402. PMID: 11390421; PMCID: PMC209322.
    86. Hirschi KD, Kreps JA, Hirschi KK. Molecular approaches to studying nutrient metabolism and function: an array of possibilities. J Nutr. 2001 May; 131(5):1605S-9S. PMID: 11340125.
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    87. Niklason LE, Abbott W, Gao J, Klagges B, Hirschi KK, Ulubayram K, Conroy N, Jones R, Vasanawala A, Sanzgiri S, Langer R. Morphologic and mechanical characteristics of engineered bovine arteries. J Vasc Surg. 2001 Mar; 33(3):628-38. PMID: 11241137.
      View in: PubMed
    88. Hirschi K. Vacuolar H+/Ca2+ transport: who's directing the traffic? Trends Plant Sci. 2001 Mar; 6(3):100-4. PMID: 11239607.
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    89. Shigaki T, Hirschi K. Characterization of CAX-like genes in plants: implications for functional diversity. Gene. 2000 Oct 31; 257(2):291-8. PMID: 11080595.
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    90. Hirschi KK, Keen CL. Nutrition in embryonic and fetal development. Nutrition. 2000 Jul-Aug; 16(7-8):495-9. PMID: 10906534.
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    91. Arbiser JL, Raab G, Rohan RM, Paul S, Hirschi K, Flynn E, Price ER, Fisher DE, Cohen C, Klagsbrun M. Isolation of mouse stromal cells associated with a human tumor using differential diphtheria toxin sensitivity. Am J Pathol. 1999 Sep; 155(3):723-9. PMID: 10487830; PMCID: PMC1866885.
    92. Niklason LE, Gao J, Abbott WM, Hirschi KK, Houser S, Marini R, Langer R. Functional arteries grown in vitro. Science. 1999 Apr 16; 284(5413):489-93. PMID: 10205057.
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    93. Hirschi KK, Rohovsky SA, Beck LH, Smith SR, D'Amore PA. Endothelial cells modulate the proliferation of mural cell precursors via platelet-derived growth factor-BB and heterotypic cell contact. Circ Res. 1999 Feb 19; 84(3):298-305. PMID: 10024303.
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    94. Hirschi KK, Rohovsky SA, D'Amore PA. PDGF, TGF-beta, and heterotypic cell-cell interactions mediate endothelial cell-induced recruitment of 10T1/2 cells and their differentiation to a smooth muscle fate. J Cell Biol. 1998 May 04; 141(3):805-14. PMID: 9566978; PMCID: PMC2132737.
    95. Hirschi KK, D'Amore PA. Control of angiogenesis by the pericyte: molecular mechanisms and significance. EXS. 1997; 79:419-28. PMID: 9002230.
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    96. Hirschi KK, D'Amore PA. Pericytes in the microvasculature. Cardiovasc Res. 1996 Oct; 32(4):687-98. PMID: 8915187.
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    97. Hirschi KK, Xu CE, Tsukamoto T, Sager R. Gap junction genes Cx26 and Cx43 individually suppress the cancer phenotype of human mammary carcinoma cells and restore differentiation potential. Cell Growth Differ. 1996 Jul; 7(7):861-70. PMID: 8809403.
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    98. Hirschi KK, Minnich BN, Moore LK, Burt JM. Oleic acid differentially affects gap junction-mediated communication in heart and vascular smooth muscle cells. Am J Physiol. 1993 Dec; 265(6 Pt 1):C1517-26. PMID: 7506488.
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