Header Logo
Last Name


TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pharmacology and Chemical Biology
AddressBaylor College of Medicine
One Baylor Plaza
Houston TX 77030
vCardDownload vCard

    Collapse Research 
    Collapse research activities and funding
    R01GM122763     (FERREON, JOSEPHINE CHU)Jan 1, 2018 - Dec 31, 2022
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Moosa MM, Ferreon JC, Ferreon ACM. Single-Molecule FRET Detection of Early-Stage Conformations in a-Synuclein Aggregation. Methods Mol Biol. 2019; 1948:221-233. PMID: 30771181.
      View in: PubMed
    2. Choi KJ, Tsoi PS, Moosa MM, Paulucci-Holthauzen A, Liao SJ, Ferreon JC, Ferreon ACM. A Chemical Chaperone Decouples TDP-43 Disordered Domain Phase Separation from Fibrillation. Biochemistry. 2018 Dec 18; 57(50):6822-6826. PMID: 30520303.
      View in: PubMed
    3. Moosa MM, Tsoi PS, Choi KJ, Ferreon ACM, Ferreon JC. Direct Single-Molecule Observation of Sequential DNA Bending Transitions by the Sox2 HMG Box. Int J Mol Sci. 2018 Dec 04; 19(12). PMID: 30518054.
      View in: PubMed
    4. Ramani S, Stewart CJ, Laucirica DR, Ajami NJ, Robertson B, Autran CA, Shinge D, Rani S, Anandan S, Hu L, Ferreon JC, Kuruvilla KA, Petrosino JF, Venkataram Prasad BV, Bode L, Kang G, Estes MK. Human milk oligosaccharides, milk microbiome and infant gut microbiome modulate neonatal rotavirus infection. Nat Commun. 2018 11 27; 9(1):5010. PMID: 30479342.
      View in: PubMed
    5. Hu L, Sankaran B, Laucirica DR, Patil K, Salmen W, Ferreon ACM, Tsoi PS, Lasanajak Y, Smith DF, Ramani S, Atmar RL, Estes MK, Ferreon JC, Prasad BVV. Glycan recognition in globally dominant human rotaviruses. Nat Commun. 2018 07 06; 9(1):2631. PMID: 29980685.
      View in: PubMed
    6. Moosa MM, Ferreon JC, Ferreon ACM. Ligand interactions and the protein order-disorder energetic continuum. Semin Cell Dev Biol. 2018 May 12. PMID: 29753880.
      View in: PubMed
    7. Ferreon JC, Jain A, Choi KJ, Tsoi PS, MacKenzie KR, Jung SY, Ferreon AC. Acetylation Disfavors Tau Phase Separation. Int J Mol Sci. 2018 May 04; 19(5). PMID: 29734651.
      View in: PubMed
    8. Moosa MM, Goodman AZ, Ferreon JC, Lee CW, Ferreon ACM, Deniz AA. Denaturant-specific effects on the structural energetics of a protein-denatured ensemble. Eur Biophys J. 2018 Jan; 47(1):89-94. PMID: 29080139.
      View in: PubMed
    9. Krois AS, Ferreon JC, Martinez-Yamout MA, Dyson HJ, Wright PE. Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein. Proc Natl Acad Sci U S A. 2016 Mar 29; 113(13):E1853-62. PMID: 26976603; PMCID: PMC4822595.
    10. Ferreon AC, Ferreon JC, Wright PE, Deniz AA. Modulation of allostery by protein intrinsic disorder. Nature. 2013 Jun 20; 498(7454):390-4. PMID: 23783631; PMCID: PMC3718496.
    11. Arai M, Ferreon JC, Wright PE. Quantitative analysis of multisite protein-ligand interactions by NMR: binding of intrinsically disordered p53 transactivation subdomains with the TAZ2 domain of CBP. J Am Chem Soc. 2012 Feb 29; 134(8):3792-803. PMID: 22280219; PMCID: PMC3290704.
    12. Lee CW, Ferreon JC, Ferreon AC, Arai M, Wright PE. Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation. Proc Natl Acad Sci U S A. 2010 Nov 09; 107(45):19290-5. PMID: 20962272; PMCID: PMC2984141.
    13. Ferreon AC, Moran CR, Ferreon JC, Deniz AA. Alteration of the alpha-synuclein folding landscape by a mutation related to Parkinson's disease. Angew Chem Int Ed Engl. 2010 May 03; 49(20):3469-72. PMID: 20544898; PMCID: PMC2972640.
    14. Ferreon JC, Martinez-Yamout MA, Dyson HJ, Wright PE. Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13260-5. PMID: 19651603; PMCID: PMC2726373.
    15. Manson A, Whitten ST, Ferreon JC, Fox RO, Hilser VJ. Characterizing the role of ensemble modulation in mutation-induced changes in binding affinity. J Am Chem Soc. 2009 May 20; 131(19):6785-93. PMID: 19397330; PMCID: PMC2711448.
    16. Ferreon JC, Lee CW, Arai M, Martinez-Yamout MA, Dyson HJ, Wright PE. Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2. Proc Natl Acad Sci U S A. 2009 Apr 21; 106(16):6591-6. PMID: 19357310; PMCID: PMC2672497.
    17. Ferreon AC, Ferreon JC, Bolen DW, Rösgen J. Protein phase diagrams II: nonideal behavior of biochemical reactions in the presence of osmolytes. Biophys J. 2007 Jan 01; 92(1):245-56. PMID: 17028144; PMCID: PMC1697851.
    18. Ferreon JC, Ferreon AC, Li K, Lemon SM. Molecular determinants of TRIF proteolysis mediated by the hepatitis C virus NS3/4A protease. J Biol Chem. 2005 May 27; 280(21):20483-92. PMID: 15767257.
      View in: PubMed
    19. Li K, Foy E, Ferreon JC, Nakamura M, Ferreon AC, Ikeda M, Ray SC, Gale M, Lemon SM. Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF. Proc Natl Acad Sci U S A. 2005 Feb 22; 102(8):2992-7. PMID: 15710891; PMCID: PMC548795.
    20. Ferreon JC, Hamburger JB, Hilser VJ. An experimental strategy to evaluate the thermodynamic stability of highly dynamic binding sites in proteins using hydrogen exchange. J Am Chem Soc. 2004 Oct 13; 126(40):12774-5. PMID: 15469262.
      View in: PubMed
    21. Hamburger JB, Ferreon JC, Whitten ST, Hilser VJ. Thermodynamic mechanism and consequences of the polyproline II (PII) structural bias in the denatured states of proteins. Biochemistry. 2004 Aug 03; 43(30):9790-9. PMID: 15274633.
      View in: PubMed
    22. Ferreon JC, Hilser VJ. Thermodynamics of binding to SH3 domains: the energetic impact of polyproline II (PII) helix formation. Biochemistry. 2004 Jun 22; 43(24):7787-97. PMID: 15196021.
      View in: PubMed
    23. Ferguson MR, Fan X, Mukherjee M, Luo J, Khan R, Ferreon JC, Hilser VJ, Shope RE, Fox RO. Directed discovery of bivalent peptide ligands to an SH3 domain. Protein Sci. 2004 Mar; 13(3):626-32. PMID: 14978303; PMCID: PMC2286729.
    24. Ferreon JC, Volk DE, Luxon BA, Gorenstein DG, Hilser VJ. Solution structure, dynamics, and thermodynamics of the native state ensemble of the Sem-5 C-terminal SH3 domain. Biochemistry. 2003 May 20; 42(19):5582-91. PMID: 12741814.
      View in: PubMed
    25. Ferreon JC, Hilser VJ. Ligand-induced changes in dynamics in the RT loop of the C-terminal SH3 domain of Sem-5 indicate cooperative conformational coupling. Protein Sci. 2003 May; 12(5):982-96. PMID: 12717021; PMCID: PMC2323869.
    26. Ferreon JC, Hilser VJ. The effect of the polyproline II (PPII) conformation on the denatured state entropy. Protein Sci. 2003 Mar; 12(3):447-57. PMID: 12592015; PMCID: PMC2312442.
    27. Soman KV, Midoro-Horiuti T, Ferreon JC, Goldblum RM, Brooks EG, Kurosky A, Braun W, Schein CH. Homology modeling and characterization of IgE binding epitopes of mountain cedar allergen Jun a 3. Biophys J. 2000 Sep; 79(3):1601-9. PMID: 10969020; PMCID: PMC1301052.
    FERREON's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    Co-Authors Expand Description
    Similar People Expand Description
    Same Department Expand Description