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John P. Lydon

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology
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    R29CA077530     (LYDON, JOHN P)Apr 1, 1998 - Mar 31, 2005
    NIH/NCI
    PROGESTERONE RECEPTOR AND BREAST CANCER
    Role: Principal Investigator

    R01CA077530     (LYDON, JOHN P)Apr 1, 1998 - Apr 30, 2010
    NIH/NCI
    PROGESTERONE RECEPTOR IN BREAST DEVELOPMENT AND CANCER
    Role: Principal Investigator

    R01HD042311     (LYDON, JOHN P)Apr 1, 2002 - Jul 31, 2024
    NIH/NICHD
    Molecular Analysis of Uterine Receptivity
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Toufaily C, Schang G, Zhou X, Wartenberg P, Boehm U, Lydon JP, Roelfsema F, Bernard DJ. Impaired LH surge amplitude in gonadotrope-specific progesterone receptor knockout mice. J Endocrinol. 2020 Jan; 244(1):111-122. PMID: 31585440.
      View in: PubMed
    2. Nanjappa MK, Mesa AM, Medrano TI, Jefferson WN, DeMayo FJ, Williams CJ, Lydon JP, Levin ER, Cooke PS. The histone methyltransferase EZH2 is required for normal uterine development and function in mice†. Biol Reprod. 2019 Aug 01; 101(2):306-317. PMID: 31201420.
      View in: PubMed
    3. Hai L, Szwarc MM, Lonard DM, Rajapakshe K, Perera D, Coarfa C, Ittmann M, Fernandez-Valdivia R, Lydon JP. Short-term RANKL exposure initiates a neoplastic transcriptional program in the basal epithelium of the murine salivary gland. Cytokine. 2019 Nov; 123:154745. PMID: 31226438.
      View in: PubMed
    4. de Oliveira V, Schaefer J, Calder M, Lydon JP, DeMayo FJ, Bhattacharya M, Radovick S, Babwah AV. Uterine Gaq/11 signaling, in a progesterone-dependent manner, critically regulates the acquisition of uterine receptivity in the female mouse. FASEB J. 2019 Aug; 33(8):9374-9387. PMID: 31091422.
      View in: PubMed
    5. Hewitt SC, Lierz SL, Garcia M, Hamilton KJ, Gruzdev A, Grimm SA, Lydon JP, Demayo FJ, Korach KS. A distal super enhancer mediates estrogen-dependent mouse uterine-specific gene transcription of Igf1 (insulin-like growth factor 1). J Biol Chem. 2019 Jun 21; 294(25):9746-9759. PMID: 31073032.
      View in: PubMed
    6. Fang X, Ni N, Lydon JP, Ivanov I, Bayless KJ, Rijnkels M, Li Q. Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit Is Required for Uterine Epithelial Integrity. Am J Pathol. 2019 Jun; 189(6):1212-1225. PMID: 30954472.
      View in: PubMed
    7. Thiele K, Hierweger AM, Riquelme JIA, Solano ME, Lydon JP, Arck PC. Impaired Progesterone-Responsiveness of CD11c+ Dendritic Cells Affects the Generation of CD4+ Regulatory T Cells and Is Associated With Intrauterine Growth Restriction in Mice. Front Endocrinol (Lausanne). 2019; 10:96. PMID: 30858825.
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    8. Szwarc MM, Hai L, Gibbons WE, Mo Q, Lanz RB, DeMayo FJ, Lydon JP. Early growth response 1 transcriptionally primes the human endometrial stromal cell for decidualization. J Steroid Biochem Mol Biol. 2019 05; 189:283-290. PMID: 30711473.
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    9. Hierweger AM, Engler JB, Friese MA, Reichardt HM, Lydon J, DeMayo F, Mittrücker HW, Arck PC. Progesterone modulates the T-cell response via glucocorticoid receptor-dependent pathways. Am J Reprod Immunol. 2019 02; 81(2):e13084. PMID: 30604567.
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    10. Hai L, Szwarc MM, Lanza DG, Heaney JD, Lydon JP. Using CRISPR/Cas9 engineering to generate a mouse with a conditional knockout allele for the promyelocytic leukemia zinc finger transcription factor. Genesis. 2019 03; 57(3):e23281. PMID: 30628160.
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    11. Ni N, Gao Y, Fang X, Melgar M, Vincent DF, Lydon JP, Bartholin L, Li Q. Glandular defects in the mouse uterus with sustained activation of TGF-beta signaling is associated with altered differentiation of endometrial stromal cells and formation of stromal compartment. PLoS One. 2018; 13(12):e0209417. PMID: 30550590.
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    12. Vasquez YM, Wang X, Wetendorf M, Franco HL, Mo Q, Wang T, Lanz RB, Young SL, Lessey BA, Spencer TE, Lydon JP, DeMayo FJ. FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation. PLoS Genet. 2018 11; 14(11):e1007787. PMID: 30452456.
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    13. Wang X, Li X, Wang T, Wu SP, Jeong JW, Kim TH, Young SL, Lessey BA, Lanz RB, Lydon JP, DeMayo FJ. SOX17 regulates uterine epithelial-stromal cross-talk acting via a distal enhancer upstream of Ihh. Nat Commun. 2018 10 24; 9(1):4421. PMID: 30356064.
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    14. Hewitt SC, Li R, Adams N, Winuthayanon W, Hamilton KJ, Donoghue LJ, Lierz SL, Garcia M, Lydon JP, DeMayo FJ, Adelman K, Korach KS. Negative elongation factor is essential for endometrial function. FASEB J. 2019 02; 33(2):3010-3023. PMID: 30332301.
      View in: PubMed
    15. Szwarc MM, Hai L, Gibbons WE, White LD, Mo Q, Kommagani R, Lanz RB, DeMayo FJ, O’Malley BW, Lydon JP. Retinoid signaling controlled by SRC-2 in decidualization revealed by transcriptomics Reproduction. 2018 10 16; 156(5):387-395. PMID: 30325183.
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    16. Szwarc MM, Kommagani R, Putluri V, Dubrulle J, Stossi F, Mancini MA, Coarfa C, Lanz RB, Putluri N, DeMayo FJ, Lydon JP, O'Malley BW. Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells. Sci Rep. 2018 09 03; 8(1):13134. PMID: 30177747.
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    17. Hai L, Szwarc MM, Wetendorf M, Wu SP, Peavey MC, Grimm SL, Edwards DP, DeMayo FJ, Lydon JP. A mouse model engineered to conditionally express the progesterone receptor-B isoform. Genesis. 2018 08; 56(8):e23223. PMID: 30004627.
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    18. Hai L, Szwarc MM, He B, Lonard DM, Kommagani R, DeMayo FJ, Lydon JP. Uterine function in the mouse requires speckle-type poz protein. Biol Reprod. 2018 06 01; 98(6):856-869. PMID: 29546395.
      View in: PubMed
    19. Szwarc MM, Hai L, Gibbons WE, Peavey MC, White LD, Mo Q, Lonard DM, Kommagani R, Lanz RB, DeMayo FJ, Lydon JP. Human endometrial stromal cell decidualization requires transcriptional reprogramming by PLZF. Biol Reprod. 2018 01 01; 98(1):15-27. PMID: 29186366.
      View in: PubMed
    20. Peavey MC, Reynolds CL, Szwarc MM, Gibbons WE, Valdes CT, DeMayo FJ, Lydon JP. A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse. J Vis Exp. 2017 10 24; (128). PMID: 29155779.
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    21. Camden AJ, Szwarc MM, Chadchan SB, DeMayo FJ, O'Malley BW, Lydon JP, Kommagani R. Growth regulation by estrogen in breast cancer 1 (GREB1) is a novel progesterone-responsive gene required for human endometrial stromal decidualization. Mol Hum Reprod. 2017 09 01; 23(9):646-653. PMID: 28911214.
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    22. Gao Y, Lin P, Lydon JP, Li Q. Conditional abrogation of transforming growth factor-ß receptor 1 in PTEN-inactivated endometrium promotes endometrial cancer progression in mice. J Pathol. 2017 09; 243(1):89-99. PMID: 28657664.
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    23. Cui T, He B, Kong S, Zhou C, Zhang H, Ni Z, Bao H, Qiu J, Xin Q, Reinberg D, Lydon JP, Lu J, Wang H. PR-Set7 deficiency limits uterine epithelial population growth hampering postnatal gland formation in mice. Cell Death Differ. 2017 12; 24(12):2013-2021. PMID: 28731465.
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    24. El Zowalaty AE, Li R, Zheng Y, Lydon JP, DeMayo FJ, Ye X. Deletion of RhoA in Progesterone Receptor-Expressing Cells Leads to Luteal Insufficiency and Infertility in Female Mice. Endocrinology. 2017 07 01; 158(7):2168-2178. PMID: 28498971.
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    25. Ran H, Kong S, Zhang S, Cheng J, Zhou C, He B, Xin Q, Lydon JP, DeMayo FJ, Feng GS, Xia G, Lu Z, Wang C, Wang H. Nuclear Shp2 directs normal embryo implantation via facilitating the ERa tyrosine phosphorylation by the Src kinase. Proc Natl Acad Sci U S A. 2017 05 02; 114(18):4816-4821. PMID: 28424251.
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    26. Mapes J, Li Q, Kannan A, Anandan L, Laws M, Lydon JP, Bagchi IC, Bagchi MK. CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy. PLoS Genet. 2017 Mar; 13(3):e1006654. PMID: 28278176.
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    27. Szwarc MM, Kommagani R, Peavey MC, Hai L, Lonard DM, Lydon JP. A bioluminescence reporter mouse that monitors expression of constitutively active ß-catenin. PLoS One. 2017; 12(3):e0173014. PMID: 28253313.
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    28. Clark NC, Pru CA, Yee SP, Lydon JP, Peluso JJ, Pru JK. Conditional Ablation of Progesterone Receptor Membrane Component 2 Causes Female Premature Reproductive Senescence. Endocrinology. 2017 03 01; 158(3):640-651. PMID: 28005395.
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    29. Wetendorf M, Wu SP, Wang X, Creighton CJ, Wang T, Lanz RB, Blok L, Tsai SY, Tsai MJ, Lydon JP, DeMayo FJ. Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment. Biol Reprod. 2017 02 01; 96(2):313-326. PMID: 28203817.
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    30. Gargiulo L, May M, Rivero EM, Copsel S, Lamb C, Lydon J, Davio C, Lanari C, Lüthy IA, Bruzzone A. A Novel Effect of ß-Adrenergic Receptor on Mammary Branching Morphogenesis and its Possible Implications in Breast Cancer. J Mammary Gland Biol Neoplasia. 2017 03; 22(1):43-57. PMID: 28074314.
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    31. Peavey MC, Reynolds CL, Szwarc MM, Gibbons WE, Valdes CT, DeMayo FJ, Lydon JP. Three-Dimensional High-Frequency Ultrasonography for Early Detection and Characterization of Embryo Implantation Site Development in the Mouse. PLoS One. 2017; 12(1):e0169312. PMID: 28046063.
      View in: PubMed
    32. Rubel CA, Wu SP, Lin L, Wang T, Lanz RB, Li X, Kommagani R, Franco HL, Camper SA, Tong Q, Jeong JW, Lydon JP, DeMayo FJ. A Gata2-Dependent Transcription Network Regulates Uterine Progesterone Responsiveness and Endometrial Function. Cell Rep. 2016 10 25; 17(5):1414-1425. PMID: 27783953.
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    33. Xiao L, Feng Q, Zhang Z, Wang F, Lydon JP, Ittmann MM, Xin L, Mitsiades N, He B. The essential role of GATA transcription factors in adult murine prostate. Oncotarget. 2016 Jul 26; 7(30):47891-47903. PMID: 27374105.
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    34. Gal A, Lin PC, Cacioppo JA, Hannon PR, Mahoney MM, Wolfe A, Fernandez-Valdivia R, Lydon JP, Elias CF, Ko C. Loss of Fertility in the Absence of Progesterone Receptor Expression in Kisspeptin Neurons of Female Mice. PLoS One. 2016; 11(7):e0159534. PMID: 27441639.
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    35. McCallum ML, Pru CA, Niikura Y, Yee SP, Lydon JP, Peluso JJ, Pru JK. Conditional Ablation of Progesterone Receptor Membrane Component 1 Results in Subfertility in the Female and Development of Endometrial Cysts. Endocrinology. 2016 09; 157(9):3309-19. PMID: 27309940.
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    36. Xiao L, Lanz RB, Frolov A, Castro PD, Zhang Z, Dong B, Xue W, Jung SY, Lydon JP, Edwards DP, Mancini MA, Feng Q, Ittmann MM, He B. The Germ Cell Gene TDRD1 as an ERG Target Gene and a Novel Prostate Cancer Biomarker. Prostate. 2016 10; 76(14):1271-84. PMID: 27272765.
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    37. Mehta FF, Son J, Hewitt SC, Jang E, Lydon JP, Korach KS, Chung SH. Distinct functions and regulation of epithelial progesterone receptor in the mouse cervix, vagina, and uterus. Oncotarget. 2016 Apr 05; 7(14):17455-67. PMID: 27007157.
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    38. Kommagani R, Szwarc MM, Vasquez YM, Peavey MC, Mazur EC, Gibbons WE, Lanz RB, DeMayo FJ, Lydon JP. The Promyelocytic Leukemia Zinc Finger Transcription Factor Is Critical for Human Endometrial Stromal Cell Decidualization. PLoS Genet. 2016 Apr; 12(4):e1005937. PMID: 27035670.
      View in: PubMed
    39. Vasquez YM, Wu SP, Anderson ML, Hawkins SM, Creighton CJ, Ray M, Tsai SY, Tsai MJ, Lydon JP, DeMayo FJ. Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis. Mol Endocrinol. 2016 May; 30(5):518-32. PMID: 27018534.
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    40. Shen J, Yao L, Lin YG, DeMayo FJ, Lydon JP, Dubeau L, Lee AS. Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development. Oncotarget. 2016 Mar 22; 7(12):14885-97. PMID: 26910913.
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    41. Stelzer IA, Mori M, DeMayo F, Lydon J, Arck PC, Solano ME. Differential mouse-strain specific expression of Junctional Adhesion Molecule (JAM)-B in placental structures. Cell Adh Migr. 2016 03 03; 10(1-2):2-17. PMID: 26914234.
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    42. Kim YS, Kim HR, Kim H, Yang SC, Park M, Yoon JA, Lim HJ, Hong SH, DeMayo FJ, Lydon JP, Choi Y, Lee DR, Song H. Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice. Sci Rep. 2016 Feb 02; 6:20242. PMID: 26833131.
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    43. Monsivais D, Clementi C, Peng J, Titus MM, Barrish JP, Creighton CJ, Lydon JP, DeMayo FJ, Matzuk MM. Uterine ALK3 is essential during the window of implantation. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):E387-95. PMID: 26721398.
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    44. Whirledge SD, Oakley RH, Myers PH, Lydon JP, DeMayo F, Cidlowski JA. Uterine glucocorticoid receptors are critical for fertility in mice through control of embryo implantation and decidualization. Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):15166-71. PMID: 26598666.
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    45. Szwarc MM, Kommagani R, Jeong JW, Wu SP, Tsai SY, Tsai MJ, O'Malley BW, DeMayo FJ, Lydon JP. Correction: Perturbing the Cellular Levels of Steroid Receptor Coactivator-2 Impairs Murine Endometrial Function. PLoS One. 2015; 10(11):e0143652. PMID: 26580555.
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    46. Han SJ, Jung SY, Wu SP, Hawkins SM, Park MJ, Kyo S, Qin J, Lydon JP, Tsai SY, Tsai MJ, DeMayo FJ, O'Malley BW. Estrogen Receptor ß Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis. Cell. 2015 Nov 05; 163(4):960-74. PMID: 26544941.
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    47. Convissar SM, Bennett J, Baumgarten SC, Lydon JP, DeMayo FJ, Stocco C. GATA4 and GATA6 Knockdown During Luteinization Inhibits Progesterone Production and Gonadotropin Responsiveness in the Corpus Luteum of Female Mice. Biol Reprod. 2015 Dec; 93(6):133. PMID: 26510866.
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    48. Bhowmik SK, Putluri V, Kommagani R, Konde SA, Lydon JP, Sreekumar A, Putluri N. Application of (13) C isotope labeling using liquid chromatography mass spectrometry (LC-MS) to determining phosphate-containing metabolic incorporation. J Mass Spectrom. 2015 Oct; 50(10):1180. PMID: 26456788.
      View in: PubMed
    49. Kommagani R, Szwarc MM, Kovanci E, Gibbons WE, Putluri N, Maity S, Creighton CJ, Sreekumar A, DeMayo FJ, Lydon JP, O'Malley BW. Correction: Acceleration of the Glycolytic Flux by Steroid Receptor Coactivator-2 Is Essential for Endometrial Decidualization. PLoS Genet. 2015 Sep; 11(9):e1005515. PMID: 26418340.
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    50. Kim TH, Yoo JY, Wang Z, Lydon JP, Khatri S, Hawkins SM, Leach RE, Fazleabas AT, Young SL, Lessey BA, Ku BJ, Jeong JW. ARID1A Is Essential for Endometrial Function during Early Pregnancy. PLoS Genet. 2015 Sep; 11(9):e1005537. PMID: 26378916.
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    51. Szwarc MM, Lydon JP, O'Malley BW. Reprint of "Steroid receptor coactivators as therapeutic targets in the female reproductive system". J Steroid Biochem Mol Biol. 2015 Sep; 153:144-50. PMID: 26291832.
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    52. Szwarc MM, Lydon JP, O'Malley BW. Steroid receptor coactivators as therapeutic targets in the female reproductive system. J Steroid Biochem Mol Biol. 2015 Nov; 154:32-8. PMID: 26151740.
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    53. Szwarc MM, Kommagani R, Jacob AP, Dougall WC, Ittmann MM, Lydon JP. Aberrant Activation of the RANK Signaling Receptor Induces Murine Salivary Gland Tumors. PLoS One. 2015; 10(6):e0128467. PMID: 26061636.
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    54. Nanjappa MK, Medrano TI, Lydon JP, Bigsby RM, Cooke PS. Maximal Dexamethasone Inhibition of Luminal Epithelial Proliferation Involves Progesterone Receptor (PR)- and Non-PR-Mediated Mechanisms in Neonatal Mouse Uterus. Biol Reprod. 2015 May; 92(5):122. PMID: 25882702.
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    55. Solano ME, Kowal MK, O'Rourke GE, Horst AK, Modest K, Plösch T, Barikbin R, Remus CC, Berger RG, Jago C, Ho H, Sass G, Parker VJ, Lydon JP, DeMayo FJ, Hecher K, Karimi K, Arck PC. Progesterone and HMOX-1 promote fetal growth by CD8+ T cell modulation. J Clin Invest. 2015 Apr; 125(4):1726-38. PMID: 25774501.
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    56. Shiah YJ, Tharmapalan P, Casey AE, Joshi PA, McKee TD, Jackson HW, Beristain AG, Chan-Seng-Yue MA, Bader GD, Lydon JP, Waterhouse PD, Boutros PC, Khokha R. A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland. Stem Cell Reports. 2015 Mar 10; 4(3):313-322. PMID: 28447939.
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    57. Bangari DS, Ashe KM, Desnick RJ, Maloney C, Lydon J, Piepenhagen P, Budman E, Leonard JP, Cheng SH, Marshall J, Thurberg BL. a-Galactosidase A knockout mice: progressive organ pathology resembles the type 2 later-onset phenotype of Fabry disease. Am J Pathol. 2015 Mar; 185(3):651-65. PMID: 25553976.
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    58. Gao Y, Duran S, Lydon JP, DeMayo FJ, Burghardt RC, Bayless KJ, Bartholin L, Li Q. Constitutive activation of transforming growth factor Beta receptor 1 in the mouse uterus impairs uterine morphology and function. Biol Reprod. 2015 Feb; 92(2):34. PMID: 25505200.
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    59. Grimm SL, Ward RD, Obr AE, Franco HL, Fernandez-Valdivia R, Kim JS, Roberts JM, Jeong JW, DeMayo FJ, Lydon JP, Edwards DP, Weigel NL. A role for site-specific phosphorylation of mouse progesterone receptor at serine 191 in vivo. Mol Endocrinol. 2014 Dec; 28(12):2025-37. PMID: 25333515.
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    60. Akgul Y, Word RA, Ensign LM, Yamaguchi Y, Lydon J, Hanes J, Mahendroo M. Hyaluronan in cervical epithelia protects against infection-mediated preterm birth. J Clin Invest. 2014 Dec; 124(12):5481-9. PMID: 25384213.
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    61. Kim TH, Yoo JY, Kim HI, Gilbert J, Ku BJ, Li J, Mills GB, Broaddus RR, Lydon JP, Lim JM, Yoon HG, Jeong JW. Mig-6 suppresses endometrial cancer associated with Pten deficiency and ERK activation. Cancer Res. 2014 Dec 15; 74(24):7371-82. PMID: 25377472.
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    62. Szwarc MM, Kommagani R, Lessey BA, Lydon JP. The p160/steroid receptor coactivator family: potent arbiters of uterine physiology and dysfunction. Biol Reprod. 2014 Nov; 91(5):122. PMID: 25297546.
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    63. Zhang S, Kong S, Wang B, Cheng X, Chen Y, Wu W, Wang Q, Shi J, Zhang Y, Wang S, Lu J, Lydon JP, DeMayo F, Pear WS, Han H, Lin H, Li L, Wang H, Wang YL, Li B, Chen Q, Duan E, Wang H. Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms. Cell Res. 2014 Aug; 24(8):925-42. PMID: 24971735.
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    64. Large MJ, Wetendorf M, Lanz RB, Hartig SM, Creighton CJ, Mancini MA, Kovanci E, Lee KF, Threadgill DW, Lydon JP, Jeong JW, DeMayo FJ. The epidermal growth factor receptor critically regulates endometrial function during early pregnancy. PLoS Genet. 2014 Jun; 10(6):e1004451. PMID: 24945252.
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    65. Szwarc MM, Kommagani R, Jeong JW, Wu SP, Tsai SY, Tsai MJ, O'Malley BW, DeMayo FJ, Lydon JP. Perturbing the cellular levels of steroid receptor coactivator-2 impairs murine endometrial function. PLoS One. 2014; 9(6):e98664. PMID: 24905738.
      View in: PubMed
    66. Putluri N, Maity S, Kommagani R, Kommangani R, Creighton CJ, Putluri V, Chen F, Nanda S, Bhowmik SK, Terunuma A, Dorsey T, Nardone A, Fu X, Shaw C, Sarkar TR, Schiff R, Lydon JP, O'Malley BW, Ambs S, Das GM, Michailidis G, Sreekumar A. Pathway-centric integrative analysis identifies RRM2 as a prognostic marker in breast cancer associated with poor survival and tamoxifen resistance. Neoplasia. 2014 May; 16(5):390-402. PMID: 25016594.
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    67. Kommagani R, Szwarc MM, Kovanci E, Creighton CJ, O'Malley BW, Demayo FJ, Lydon JP. A murine uterine transcriptome, responsive to steroid receptor coactivator-2, reveals transcription factor 23 as essential for decidualization of human endometrial stromal cells. Biol Reprod. 2014 Apr; 90(4):75. PMID: 24571987.
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    68. van der Horst PH, van der Zee M, Heijmans-Antonissen C, Jia Y, DeMayo FJ, Lydon JP, van Deurzen CH, Ewing PC, Burger CW, Blok LJ. A mouse model for endometrioid ovarian cancer arising from the distal oviduct. Int J Cancer. 2014 Sep 01; 135(5):1028-37. PMID: 24474556.
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    69. Kim TH, Yu Y, Luo L, Lydon JP, Jeong JW, Kim JJ. Activated AKT pathway promotes establishment of endometriosis. Endocrinology. 2014 May; 155(5):1921-30. PMID: 24605828.
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    70. Filant J, DeMayo FJ, Pru JK, Lydon JP, Spencer TE. Fibroblast growth factor receptor two (FGFR2) regulates uterine epithelial integrity and fertility in mice. Biol Reprod. 2014 Jan; 90(1):7. PMID: 24227756.
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    71. Bhowmik SK, Putluri V, Kommagani R, Konde SA, Lydon JP, Sreekumar A, Putluri N. Application of 13C isotope labeling using liquid chromatography mass spectrometry (LC-MS) to determining phosphate-containing metabolic incorporation. J Mass Spectrom. 2013 Dec; 48(12):1270-5. PMID: 24338880.
      View in: PubMed
    72. Clementi C, Tripurani SK, Large MJ, Edson MA, Creighton CJ, Hawkins SM, Kovanci E, Kaartinen V, Lydon JP, Pangas SA, DeMayo FJ, Matzuk MM. Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans. PLoS Genet. 2013 Nov; 9(11):e1003863. PMID: 24244176.
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    73. Bruno RD, Boulanger CA, Rosenfield SM, Anderson LH, Lydon JP, Smith GH. Paracrine-rescued lobulogenesis in chimeric outgrowths comprising progesterone-receptor-null mammary epithelium and redirected wild-type testicular cells. J Cell Sci. 2014 Jan 01; 127(Pt 1):27-32. PMID: 24190884.
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    74. Kommagani R, Szwarc MM, Kovanci E, Gibbons WE, Putluri N, Maity S, Creighton CJ, Sreekumar A, DeMayo FJ, Lydon JP, O'Malley BW. Acceleration of the glycolytic flux by steroid receptor coactivator-2 is essential for endometrial decidualization. PLoS Genet. 2013 Oct; 9(10):e1003900. PMID: 24204309.
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    75. Oh SJ, Shin JH, Kim TH, Lee HS, Yoo JY, Ahn JY, Broaddus RR, Taketo MM, Lydon JP, Leach RE, Lessey BA, Fazleabas AT, Lim JM, Jeong JW. ß-Catenin activation contributes to the pathogenesis of adenomyosis through epithelial-mesenchymal transition. J Pathol. 2013 Oct; 231(2):210-22. PMID: 23784889.
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    76. Filant J, Lydon JP, Spencer TE. Integrated chromatin immunoprecipitation sequencing and microarray analysis identifies FOXA2 target genes in the glands of the mouse uterus. FASEB J. 2014 Jan; 28(1):230-43. PMID: 24025729.
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    77. Obr AE, Grimm SL, Bishop KA, Pike JW, Lydon JP, Edwards DP. Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells. Mol Endocrinol. 2013 Nov; 27(11):1808-24. PMID: 24014651.
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    78. Yoo YA, Son J, Mehta FF, DeMayo FJ, Lydon JP, Chung SH. Progesterone signaling inhibits cervical carcinogenesis in mice. Am J Pathol. 2013 Nov; 183(5):1679-1687. PMID: 24012679.
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    79. Kim M, Park HJ, Seol JW, Jang JY, Cho YS, Kim KR, Choi Y, Lydon JP, Demayo FJ, Shibuya M, Ferrara N, Sung HK, Nagy A, Alitalo K, Koh GY. VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy. EMBO Mol Med. 2013 Sep; 5(9):1415-30. PMID: 23853117.
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    80. Lindberg ME, Stodden GR, King ML, MacLean JA, Mann JL, DeMayo FJ, Lydon JP, Hayashi K. Loss of CDH1 and Pten accelerates cellular invasiveness and angiogenesis in the mouse uterus. Biol Reprod. 2013 Jul; 89(1):8. PMID: 23740945.
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    173. Schneider JS, Stone MK, Wynne-Edwards KE, Horton TH, Lydon J, O'Malley B, Levine JE. Progesterone receptors mediate male aggression toward infants. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2951-6. PMID: 12601162.
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    174. Chatterton RT, Lydon JP, Mehta RG, Mateo ET, Pletz A, Jordan VC. Role of the progesterone receptor (PR) in susceptibility of mouse mammary gland to 7,12-dimethylbenz[a]anthracene-induced hormone-independent preneoplastic lesions in vitro. Cancer Lett. 2002 Dec 15; 188(1-2):47-52. PMID: 12406547.
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    175. Grimm SL, Seagroves TN, Kabotyanski EB, Hovey RC, Vonderhaar BK, Lydon JP, Miyoshi K, Hennighausen L, Ormandy CJ, Lee AV, Stull MA, Wood TL, Rosen JM. Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development. Mol Endocrinol. 2002 Dec; 16(12):2675-91. PMID: 12456789.
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    176. Picard F, Wanatabe M, Schoonjans K, Lydon J, O'Malley BW, Auwerx J. Progesterone receptor knockout mice have an improved glucose homeostasis secondary to beta -cell proliferation. Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24):15644-8. PMID: 12438645.
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    177. Ismail PM, Li J, DeMayo FJ, O'Malley BW, Lydon JP. A novel LacZ reporter mouse reveals complex regulation of the progesterone receptor promoter during mammary gland development. Mol Endocrinol. 2002 Nov; 16(11):2475-89. PMID: 12403837.
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    178. Mills DJ, Coffman CB, Teasdale JR, Everts KL, Abdul-Baki AA, Lydon J, Anderson JD. Foliar Disease in Fresh-Market Tomato Grown in Differing Bed Strategies and Fungicide Spray Programs. Plant Dis. 2002 Sep; 86(9):955-959. PMID: 30818555.
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    179. Soyal S, Ismail PM, Li J, Mulac-Jericevic B, Conneely OM, Lydon JP. Progesterone's role in mammary gland development and tumorigenesis as disclosed by experimental mouse genetics. Breast Cancer Res. 2002; 4(5):191-6. PMID: 12223123.
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    180. Conneely OM, Mulac-Jericevic B, DeMayo F, Lydon JP, O'Malley BW. Reproductive functions of progesterone receptors. Recent Prog Horm Res. 2002; 57:339-55. PMID: 12017551.
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    181. Karas RH, van Eickels M, Lydon JP, Roddy S, Kwoun M, Aronovitz M, Baur WE, Conneely O, O'Malley BW, Mendelsohn ME. A complex role for the progesterone receptor in the response to vascular injury. J Clin Invest. 2001 Aug; 108(4):611-8. PMID: 11518735.
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    182. Conneely OM, Mulac-Jericevic B, Lydon JP, De Mayo FJ. Reproductive functions of the progesterone receptor isoforms: lessons from knock-out mice. Mol Cell Endocrinol. 2001 Jun 20; 179(1-2):97-103. PMID: 11420134.
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    183. Kurita T, Wang YZ, Donjacour AA, Zhao C, Lydon JP, O'Malley BW, Isaacs JT, Dahiya R, Cunha GR. Paracrine regulation of apoptosis by steroid hormones in the male and female reproductive system. Cell Death Differ. 2001 Feb; 8(2):192-200. PMID: 11313721.
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    184. Krebs CJ, Jarvis ED, Chan J, Lydon JP, Ogawa S, Pfaff DW. A membrane-associated progesterone-binding protein, 25-Dx, is regulated by progesterone in brain regions involved in female reproductive behaviors. Proc Natl Acad Sci U S A. 2000 Nov 07; 97(23):12816-21. PMID: 11070092.
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    185. Robker RL, Russell DL, Yoshioka S, Sharma SC, Lydon JP, O'Malley BW, Espey LL, Richards JS. Ovulation: a multi-gene, multi-step process. Steroids. 2000 Oct-Nov; 65(10-11):559-70. PMID: 11108860.
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    186. Conneely OM, Lydon JP. Progesterone receptors in reproduction: functional impact of the A and B isoforms. Steroids. 2000 Oct-Nov; 65(10-11):571-7. PMID: 11108861.
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    187. Mulac-Jericevic B, Mullinax RA, DeMayo FJ, Lydon JP, Conneely OM. Subgroup of reproductive functions of progesterone mediated by progesterone receptor-B isoform. Science. 2000 Sep 08; 289(5485):1751-4. PMID: 10976068.
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    188. Lydon JP, Sivaraman L, Conneely OM. A reappraisal of progesterone action in the mammary gland. J Mammary Gland Biol Neoplasia. 2000 Jul; 5(3):325-38. PMID: 14973394.
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    189. Robker RL, Russell DL, Espey LL, Lydon JP, O'Malley BW, Richards JS. Progesterone-regulated genes in the ovulation process: ADAMTS-1 and cathepsin L proteases. Proc Natl Acad Sci U S A. 2000 Apr 25; 97(9):4689-94. PMID: 10781075.
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    190. Kurita T, Lee KJ, Cooke PS, Lydon JP, Cunha GR. Paracrine regulation of epithelial progesterone receptor and lactoferrin by progesterone in the mouse uterus. Biol Reprod. 2000 Apr; 62(4):831-8. PMID: 10727250.
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    191. Seagroves TN, Lydon JP, Hovey RC, Vonderhaar BK, Rosen JM. C/EBPbeta (CCAAT/enhancer binding protein) controls cell fate determination during mammary gland development. Mol Endocrinol. 2000 Mar; 14(3):359-68. PMID: 10707954.
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    192. Conneely OM, Lydon JP, De Mayo F, O'Malley BW. Reproductive functions of the progesterone receptor. J Soc Gynecol Investig. 2000 Jan-Feb; 7(1 Suppl):S25-32. PMID: 10732326.
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    193. Lydon JP, Ge G, Kittrell FS, Medina D, O'Malley BW. Murine mammary gland carcinogenesis is critically dependent on progesterone receptor function. Cancer Res. 1999 Sep 01; 59(17):4276-84. PMID: 10485472.
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    194. Chappell PE, Schneider JS, Kim P, Xu M, Lydon JP, O'Malley BW, Levine JE. Absence of gonadotropin surges and gonadotropin-releasing hormone self-priming in ovariectomized (OVX), estrogen (E2)-treated, progesterone receptor knockout (PRKO) mice. Endocrinology. 1999 Aug; 140(8):3653-8. PMID: 10433223.
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    195. Vázquez F, Rodríguez-Manzaneque JC, Lydon JP, Edwards DP, O'Malley BW, Iruela-Arispe ML. Progesterone regulates proliferation of endothelial cells. J Biol Chem. 1999 Jan 22; 274(4):2185-92. PMID: 9890981.
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    196. Phelps SM, Lydon JP, O'malley BW, Crews D. Regulation of male sexual behavior by progesterone receptor, sexual experience, and androgen. Horm Behav. 1998 Dec; 34(3):294-302. PMID: 9878278.
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    197. Kurita T, Young P, Brody JR, Lydon JP, O'Malley BW, Cunha GR. Stromal progesterone receptors mediate the inhibitory effects of progesterone on estrogen-induced uterine epithelial cell deoxyribonucleic acid synthesis. Endocrinology. 1998 Nov; 139(11):4708-13. PMID: 9794483.
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    198. Brisken C, Park S, Vass T, Lydon JP, O'Malley BW, Weinberg RA. A paracrine role for the epithelial progesterone receptor in mammary gland development. Proc Natl Acad Sci U S A. 1998 Apr 28; 95(9):5076-81. PMID: 9560231.
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    199. Humphreys RC, Lydon JP, O'Malley BW, Rosen JM. Use of PRKO mice to study the role of progesterone in mammary gland development. J Mammary Gland Biol Neoplasia. 1997 Oct; 2(4):343-54. PMID: 10935022.
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    200. Chappell PE, Lydon JP, Conneely OM, O'Malley BW, Levine JE. Endocrine defects in mice carrying a null mutation for the progesterone receptor gene. Endocrinology. 1997 Oct; 138(10):4147-52. PMID: 9322923.
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    201. Said TK, Conneely OM, Medina D, O'Malley BW, Lydon JP. Progesterone, in addition to estrogen, induces cyclin D1 expression in the murine mammary epithelial cell, in vivo. Endocrinology. 1997 Sep; 138(9):3933-9. PMID: 9275084.
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    202. Qiu Y, Pereira FA, DeMayo FJ, Lydon JP, Tsai SY, Tsai MJ. Null mutation of mCOUP-TFI results in defects in morphogenesis of the glossopharyngeal ganglion, axonal projection, and arborization. Genes Dev. 1997 Aug 01; 11(15):1925-37. PMID: 9271116.
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    203. Humphreys RC, Lydon J, O'Malley BW, Rosen JM. Mammary gland development is mediated by both stromal and epithelial progesterone receptors. Mol Endocrinol. 1997 Jun; 11(6):801-11. PMID: 9171243.
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    204. Saucedo-Cardenas O, Kardon R, Ediger TR, Lydon JP, Conneely OM. Cloning and structural organization of the gene encoding the murine nuclear receptor transcription factor, NURR1. Gene. 1997 Mar 10; 187(1):135-9. PMID: 9073077.
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    205. Mani SK, Allen JM, Lydon JP, Mulac-Jericevic B, Blaustein JD, DeMayo FJ, Conneely O, O'Malley BW. Dopamine requires the unoccupied progesterone receptor to induce sexual behavior in mice. Mol Endocrinol. 1996 Dec; 10(12):1728-37. PMID: 8961281.
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    206. Lydon JP, DeMayo FJ, Conneely OM, O'Malley BW. Reproductive phenotpes of the progesterone receptor null mutant mouse. J Steroid Biochem Mol Biol. 1996 Jan; 56(1-6 Spec No):67-77. PMID: 8603049.
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    207. Lydon JP, DeMayo FJ, Funk CR, Mani SK, Hughes AR, Montgomery CA, Shyamala G, Conneely OM, O'Malley BW. Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities. Genes Dev. 1995 Sep 15; 9(18):2266-78. PMID: 7557380.
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    208. Lydon JP, O'Malley BR, Saucedo O, Lee T, Headon DR, Conneely OM. Nucleotide and primary amino acid sequence of porcine lactoferrin. Biochim Biophys Acta. 1992 Aug 17; 1132(1):97-9. PMID: 1511016.
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    209. Lydon JP, Power RF, Conneely OM. Differential modes of activation define orphan subclasses within the steroid/thyroid receptor superfamily. Gene Expr. 1992; 2(3):273-83. PMID: 1450665.
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    210. Power RF, Lydon JP, Conneely OM, O'Malley BW. Dopamine activation of an orphan of the steroid receptor superfamily. Science. 1991 Jun 14; 252(5012):1546-8. PMID: 2047861.
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