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JOHN THOMAS BROSNAN

TitleAdjunct Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Nutrition
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. O'Reilly J, Pangilinan F, Hokamp K, Ueland PM, Brosnan JT, Brosnan ME, Brody LC, Molloy AM. The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites. Mol Genet Metab Rep. 2018 Sep; 16:20-22. PMID: 29988937.
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    2. MacMillan L, Tingley G, Young SK, Clow KA, Randell EW, Brosnan ME, Brosnan JT. Cobalamin Deficiency Results in Increased Production of Formate Secondary to Decreased Mitochondrial Oxidation of One-Carbon Units in Rats. J Nutr. 2018 03 01; 148(3):358-363. PMID: 29546303.
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    3. Brosnan JT, Mills JL, Ueland PM, Shane B, Fan R, Chiu CY, Pangilinan F, Brody LC, Brosnan ME, Pongnopparat T, Molloy AM. Lifestyle, metabolite, and genetic determinants of formate concentrations in a cross-sectional study in young, healthy adults. Am J Clin Nutr. 2018 03 01; 107(3):345-354. PMID: 29566195.
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    4. Young A, Gardiner D, Brosnan ME, Brosnan JT, Mailloux RJ. Physiological levels of formate activate mitochondrial superoxide/hydrogen peroxide release from mouse liver mitochondria. FEBS Lett. 2017 08; 591(16):2426-2438. PMID: 28771687.
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    5. MacMillan L, Lamarre SG, daSilva RP, Jacobs RL, Brosnan ME, Brosnan JT. Riboflavin Deficiency in Rats Decreases de novo Formate Production but Does Not Affect Plasma Formate Concentration. J Nutr. 2017 03; 147(3):346-352. PMID: 28122934.
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    6. Mailloux RJ, Young A, Chalker J, Gardiner D, O'Brien M, Slade L, Brosnan JT. Choline and dimethylglycine produce superoxide/hydrogen peroxide from the electron transport chain in liver mitochondria. FEBS Lett. 2016 Dec; 590(23):4318-4328. PMID: 27761911.
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    7. Brosnan ME, Brosnan JT. Formate: The Neglected Member of One-Carbon Metabolism. Annu Rev Nutr. 2016 07 17; 36:369-88. PMID: 27431368.
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    8. Sudiwala S, De Castro SC, Leung KY, Brosnan JT, Brosnan ME, Mills K, Copp AJ, Greene ND. Formate supplementation enhances folate-dependent nucleotide biosynthesis and prevents spina bifida in a mouse model of folic acid-resistant neural tube defects. Biochimie. 2016 Jul; 126:63-70. PMID: 26924399.
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    9. Brosnan ME, Brosnan JT. The role of dietary creatine. Amino Acids. 2016 08; 48(8):1785-91. PMID: 26874700.
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    10. Deminice R, de Castro GS, Brosnan ME, Brosnan JT. Creatine supplementation as a possible new therapeutic approach for fatty liver disease: early findings. Amino Acids. 2016 08; 48(8):1983-91. PMID: 26832170.
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    11. Brosnan ME, MacMillan L, Stevens JR, Brosnan JT. Division of labour: how does folate metabolism partition between one-carbon metabolism and amino acid oxidation? Biochem J. 2015 Dec 01; 472(2):135-46. PMID: 26567272.
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    12. Washburn SE, Caudill MA, Malysheva O, MacFarlane AJ, Behan NA, Harnett B, MacMillan L, Pongnopparat T, Brosnan JT, Brosnan ME. Formate metabolism in fetal and neonatal sheep. Am J Physiol Endocrinol Metab. 2015 May 15; 308(10):E921-7. PMID: 25805190.
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    13. Pai YJ, Leung KY, Savery D, Hutchin T, Prunty H, Heales S, Brosnan ME, Brosnan JT, Copp AJ, Greene ND. Glycine decarboxylase deficiency causes neural tube defects and features of non-ketotic hyperglycinemia in mice. Nat Commun. 2015 Mar 04; 6:6388. PMID: 25736695.
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    14. Deac OM, Mills JL, Shane B, Midttun Ø, Ueland PM, Brosnan JT, Brosnan ME, Laird E, Gibney ER, Fan R, Wang Y, Brody LC, Molloy AM. Tryptophan catabolism and vitamin B-6 status are affected by gender and lifestyle factors in healthy young adults. J Nutr. 2015 Apr; 145(4):701-7. PMID: 25833774.
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    15. Deminice R, da Silva RP, Lamarre SG, Kelly KB, Jacobs RL, Brosnan ME, Brosnan JT. Betaine supplementation prevents fatty liver induced by a high-fat diet: effects on one-carbon metabolism. Amino Acids. 2015 Apr; 47(4):839-46. PMID: 25577261.
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    16. Morrow GP, MacMillan L, Lamarre SG, Young SK, MacFarlane AJ, Brosnan ME, Brosnan JT. In vivo kinetics of formate metabolism in folate-deficient and folate-replete rats. J Biol Chem. 2015 Jan 23; 290(4):2244-50. PMID: 25480787.
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    17. Field MS, Kamynina E, Agunloye OC, Liebenthal RP, Lamarre SG, Brosnan ME, Brosnan JT, Stover PJ. Nuclear enrichment of folate cofactors and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) protect de novo thymidylate biosynthesis during folate deficiency. J Biol Chem. 2014 Oct 24; 289(43):29642-50. PMID: 25213861.
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    18. Brosnan JT, Drewnowski A, Friedman MI. Is there a relationship between dietary MSG and [corrected] obesity in animals or humans? Amino Acids. 2014 Sep; 46(9):2075-87. PMID: 24927698.
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    19. Lamarre SG, MacMillan L, Morrow GP, Randell E, Pongnopparat T, Brosnan ME, Brosnan JT. An isotope-dilution, GC-MS assay for formate and its application to human and animal metabolism. Amino Acids. 2014 Aug; 46(8):1885-91. PMID: 24748098.
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    20. Rooyackers O, Brosnan JT. Amino acids and proteins important for all; from stem cells, to the critically ill patient and even general bone health. Curr Opin Clin Nutr Metab Care. 2014 Jan; 17(1):59-60. PMID: 24310055.
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    21. da Silva RP, Clow K, Brosnan JT, Brosnan ME. Synthesis of guanidinoacetate and creatine from amino acids by rat pancreas. Br J Nutr. 2014 Feb; 111(4):571-7. PMID: 24103317.
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    22. Lamarre SG, Morrow G, Macmillan L, Brosnan ME, Brosnan JT. Formate: an essential metabolite, a biomarker, or more? Clin Chem Lab Med. 2013 Mar 01; 51(3):571-8. PMID: 23241677.
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    23. Edison EE, Brosnan ME, Aziz K, Brosnan JT. Creatine and guanidinoacetate content of human milk and infant formulas: implications for creatine deficiency syndromes and amino acid metabolism. Br J Nutr. 2013 Sep 28; 110(6):1075-8. PMID: 23388580.
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    24. Brosnan JT, Rooyackers O. Amino acids: the most versatile nutrients. Curr Opin Clin Nutr Metab Care. 2013 Jan; 16(1):56. PMID: 23132169.
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    25. da Silva R, Levillain O, Brosnan JT, Araneda S, Brosnan ME. The effect of portacaval anastomosis on the expression of glutamine synthetase and ornithine aminotransferase in perivenous hepatocytes. Can J Physiol Pharmacol. 2013 May; 91(5):362-8. PMID: 23656379.
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    26. Brosnan JT, Brosnan ME. Glutamate: a truly functional amino acid. Amino Acids. 2013 Sep; 45(3):413-8. PMID: 22526238.
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    27. Brosnan J, Rooyackers O. The importance of amino acids as independent metabolites, signalling molecules and as building blocks for protein. Curr Opin Clin Nutr Metab Care. 2012 Jan; 15(1):47-8. PMID: 22123615.
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    28. Lamarre SG, Molloy AM, Reinke SN, Sykes BD, Brosnan ME, Brosnan JT. Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration. Am J Physiol Endocrinol Metab. 2012 Jan 01; 302(1):E61-7. PMID: 21934042.
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    29. Deminice R, da Silva RP, Lamarre SG, Brown C, Furey GN, McCarter SA, Jordao AA, Kelly KB, King-Jones K, Jacobs RL, Brosnan ME, Brosnan JT. Creatine supplementation prevents the accumulation of fat in the livers of rats fed a high-fat diet. J Nutr. 2011 Oct; 141(10):1799-804. PMID: 21880953.
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    30. Brosnan JT, da Silva RP, Brosnan ME. The metabolic burden of creatine synthesis. Amino Acids. 2011 May; 40(5):1325-31. PMID: 21387089.
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    31. Treberg JR, Brosnan ME, Brosnan JT. The simultaneous determination of NAD(H) and NADP(H) utilization by glutamate dehydrogenase. Mol Cell Biochem. 2010 Nov; 344(1-2):253-9. PMID: 20697932.
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    32. Lamarre SG, Edison EE, Wijekoon EP, Brosnan ME, Brosnan JT. Suckling rat pups accumulate creatine primarily via de novo synthesis rather than from dam milk. J Nutr. 2010 Sep; 140(9):1570-3. PMID: 20660282.
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    33. Treberg JR, Clow KA, Greene KA, Brosnan ME, Brosnan JT. Systemic activation of glutamate dehydrogenase increases renal ammoniagenesis: implications for the hyperinsulinism/hyperammonemia syndrome. Am J Physiol Endocrinol Metab. 2010 Jun; 298(6):E1219-25. PMID: 20332361.
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    34. Brosnan JT, Brosnan ME. Creatine metabolism and the urea cycle. Mol Genet Metab. 2010; 100 Suppl 1:S49-52. PMID: 20304692.
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    35. Treberg JR, Brosnan ME, Watford M, Brosnan JT. On the reversibility of glutamate dehydrogenase and the source of hyperammonemia in the hyperinsulinism/hyperammonemia syndrome. Adv Enzyme Regul. 2010; 50(1):34-43. PMID: 19895831.
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    36. Brosnan ME, Brosnan JT. Hepatic glutamate metabolism: a tale of 2 hepatocytes. Am J Clin Nutr. 2009 Sep; 90(3):857S-861S. PMID: 19625684.
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    37. Zhao Y, Su B, Jacobs RL, Kennedy B, Francis GA, Waddington E, Brosnan JT, Vance JE, Vance DE. Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice. Arterioscler Thromb Vasc Biol. 2009 Sep; 29(9):1349-55. PMID: 19520976.
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    38. Brosnan JT, Wijekoon EP, Warford-Woolgar L, Trottier NL, Brosnan ME, Brunton JA, Bertolo RF. Creatine synthesis is a major metabolic process in neonatal piglets and has important implications for amino acid metabolism and methyl balance. J Nutr. 2009 Jul; 139(7):1292-7. PMID: 19474158.
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    39. da Silva RP, Nissim I, Brosnan ME, Brosnan JT. Creatine synthesis: hepatic metabolism of guanidinoacetate and creatine in the rat in vitro and in vivo. Am J Physiol Endocrinol Metab. 2009 Feb; 296(2):E256-61. PMID: 19017728.
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    40. Clow KA, Treberg JR, Brosnan ME, Brosnan JT. Elevated tissue betaine contents in developing rats are due to dietary betaine, not to synthesis. J Nutr. 2008 Sep; 138(9):1641-6. PMID: 18716163.
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    41. Wijekoon EP, Brosnan ME, Brosnan JT. Homocysteine metabolism in diabetes. Biochem Soc Trans. 2007 Nov; 35(Pt 5):1175-9. PMID: 17956306.
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    42. Edison EE, Brosnan ME, Meyer C, Brosnan JT. Creatine synthesis: production of guanidinoacetate by the rat and human kidney in vivo. Am J Physiol Renal Physiol. 2007 Dec; 293(6):F1799-804. PMID: 17928413.
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    43. Brosnan ME, Brosnan JT. Orotic acid excretion and arginine metabolism. J Nutr. 2007 06; 137(6 Suppl 2):1656S-1661S. PMID: 17513443.
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    44. Brosnan ME, Edison EE, da Silva R, Brosnan JT. New insights into creatine function and synthesis. Adv Enzyme Regul. 2007; 47:252-60. PMID: 17335874.
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    45. Brosnan JT, da Silva R, Brosnan ME. Amino acids and the regulation of methyl balance in humans. Curr Opin Clin Nutr Metab Care. 2007 Jan; 10(1):52-7. PMID: 17143055.
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    46. Mudd SH, Brosnan JT, Brosnan ME, Jacobs RL, Stabler SP, Allen RH, Vance DE, Wagner C. Methyl balance and transmethylation fluxes in humans. Am J Clin Nutr. 2007 Jan; 85(1):19-25. PMID: 17209172.
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    47. Brosnan JT, Brosnan ME. Creatine: endogenous metabolite, dietary, and therapeutic supplement. Annu Rev Nutr. 2007; 27:241-61. PMID: 17430086.
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    48. Brosnan JT, Brosnan ME. The sulfur-containing amino acids: an overview. J Nutr. 2006 06; 136(6 Suppl):1636S-1640S. PMID: 16702333.
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    49. Stead LM, Brosnan JT, Brosnan ME, Vance DE, Jacobs RL. Is it time to reevaluate methyl balance in humans? Am J Clin Nutr. 2006 Jan; 83(1):5-10. PMID: 16400042.
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    50. Brosnan JT, Brosnan ME. Branched-chain amino acids: enzyme and substrate regulation. J Nutr. 2006 01; 136(1 Suppl):207S-11S. PMID: 16365084.
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    51. Ratnam S, Wijekoon EP, Hall B, Garrow TA, Brosnan ME, Brosnan JT. Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver. Am J Physiol Endocrinol Metab. 2006 May; 290(5):E933-9. PMID: 16352668.
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    52. Wijekoon EP, Hall B, Ratnam S, Brosnan ME, Zeisel SH, Brosnan JT. Homocysteine metabolism in ZDF (type 2) diabetic rats. Diabetes. 2005 Nov; 54(11):3245-51. PMID: 16249451.
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    53. Brosnan JT. Metabolic design principles: chemical and physical determinants of cell chemistry. Adv Enzyme Regul. 2005; 45:27-36. PMID: 16126257.
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    54. Dickson TM, Edison E, Brosnan JT, House JD. Hyperglycinemia due to folate deficiency in rats: evidence for the lack of involvement of the hepatic glycine cleavage system. J Nutr Biochem. 2005 Dec; 16(12):736-42. PMID: 16081265.
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    55. Jacobs RL, Stead LM, Devlin C, Tabas I, Brosnan ME, Brosnan JT, Vance DE. Physiological regulation of phospholipid methylation alters plasma homocysteine in mice. J Biol Chem. 2005 Aug 05; 280(31):28299-305. PMID: 15958390.
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    56. Brosnan JT. The Fourth Workshop on the Assessment of Adequate intake of Dietary Amino Acids: general discussion of sessions 1 and 2. J Nutr. 2005 06; 135(6 Suppl):1576S-9S. PMID: 15930472.
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    57. Shields DJ, Lingrell S, Agellon LB, Brosnan JT, Vance DE. Localization-independent regulation of homocysteine secretion by phosphatidylethanolamine N-methyltransferase. J Biol Chem. 2005 Jul 22; 280(29):27339-44. PMID: 15927961.
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    58. Brosnan JT. Homocysteine and cardiovascular disease: interactions between nutrition, genetics and lifestyle. Can J Appl Physiol. 2004 Dec; 29(6):773-80. PMID: 15630149.
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    59. Brosnan ME, Brosnan JT. Renal arginine metabolism. J Nutr. 2004 10; 134(10 Suppl):2791S-2795S; discussion 2796S-2797S. PMID: 15465786.
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    60. Wijekoon EP, Skinner C, Brosnan ME, Brosnan JT. Amino acid metabolism in the Zucker diabetic fatty rat: effects of insulin resistance and of type 2 diabetes. Can J Physiol Pharmacol. 2004 Jul; 82(7):506-14. PMID: 15389298.
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    61. Brosnan JT, Brosnan ME, Nissim I. A window into cellular metabolism: hepatic metabolism of (15)N-labelled substrates. Metab Eng. 2004 Jan; 6(1):6-11. PMID: 14734251.
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    62. Brosnan JT, Jacobs RL, Stead LM, Brosnan ME. Methylation demand: a key determinant of homocysteine metabolism. Acta Biochim Pol. 2004; 51(2):405-13. PMID: 15218538.
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    63. Stead LM, Jacobs RL, Brosnan ME, Brosnan JT. Methylation demand and homocysteine metabolism. Adv Enzyme Regul. 2004; 44:321-33. PMID: 15581499.
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    64. Brosnan JT. Interorgan amino acid transport and its regulation. J Nutr. 2003 06; 133(6 Suppl 1):2068S-2072S. PMID: 12771367.
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    65. Noga AA, Stead LM, Zhao Y, Brosnan ME, Brosnan JT, Vance DE. Plasma homocysteine is regulated by phospholipid methylation. J Biol Chem. 2003 Feb 21; 278(8):5952-5. PMID: 12482759.
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    66. Ratnam S, Maclean KN, Jacobs RL, Brosnan ME, Kraus JP, Brosnan JT. Hormonal regulation of cystathionine beta-synthase expression in liver. J Biol Chem. 2002 Nov 08; 277(45):42912-8. PMID: 12198128.
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    67. Brosnan JT, Brosnan ME. Hepatic glutaminase--a special role in urea synthesis? Nutrition. 2002 Jun; 18(6):455-7. PMID: 12044815.
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    68. Brosnan JT, Brosnan ME, Nissim I. Application of 15N to the study of hepatic nitrogen metabolism. Adv Enzyme Regul. 2002; 42:305-15. PMID: 12123722.
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    69. Brosnan JT. Amino acids, then and now--a reflection on Sir Hans Krebs' contribution to nitrogen metabolism. IUBMB Life. 2001 Dec; 52(6):265-70. PMID: 11895074.
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    70. House JD, Hall BN, Brosnan JT. Threonine metabolism in isolated rat hepatocytes. Am J Physiol Endocrinol Metab. 2001 Dec; 281(6):E1300-7. PMID: 11701446.
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    71. Stead LM, Au KP, Jacobs RL, Brosnan ME, Brosnan JT. Methylation demand and homocysteine metabolism: effects of dietary provision of creatine and guanidinoacetate. Am J Physiol Endocrinol Metab. 2001 Nov; 281(5):E1095-100. PMID: 11595668.
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    72. Jacobs RL, Stead LM, Brosnan ME, Brosnan JT. Hyperglucagonemia in rats results in decreased plasma homocysteine and increased flux through the transsulfuration pathway in liver. J Biol Chem. 2001 Nov 23; 276(47):43740-7. PMID: 11559709.
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    73. Brosnan JT, Brosnan ME, Yudkoff M, Nissim I, Daikhin Y, Lazarow A, Horyn O, Nissim I. Alanine metabolism in the perfused rat liver. Studies with (15)N. J Biol Chem. 2001 Aug 24; 276(34):31876-82. PMID: 11423541.
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    74. Stead LM, Brosnan ME, Brosnan JT. Characterization of homocysteine metabolism in the rat liver. Biochem J. 2000 Sep 15; 350 Pt 3:685-92. PMID: 10970780.
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    75. Jacobs RL, Stead LM, Brosnan ME, Brosnan JT. Plasma homocysteine is decreased in the hypothyroid rat. Can J Physiol Pharmacol. 2000 Jul; 78(7):565-70. PMID: 10926163.
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    76. House JD, March SB, Ratnam S, Ives E, Brosnan JT, Friel JK. Folate and vitamin B12 status of women in Newfoundland at their first prenatal visit. CMAJ. 2000 May 30; 162(11):1557-9. PMID: 10862228.
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    77. Brosnan JT. Glutamate, at the interface between amino acid and carbohydrate metabolism. J Nutr. 2000 04; 130(4S Suppl):988S-90S. PMID: 10736367.
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    78. O'Sullivan D, Brosnan JT, Brosnan ME. Catabolism of arginine and ornithine in the perfused rat liver: effect of dietary protein and of glucagon. Am J Physiol Endocrinol Metab. 2000 Mar; 278(3):E516-21. PMID: 10710507.
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    79. Nissim I, Brosnan ME, Yudkoff M, Brosnan JT. Studies of hepatic glutamine metabolism in the perfused rat liver with (15)N-labeled glutamine. J Biol Chem. 1999 Oct 08; 274(41):28958-65. PMID: 10506142.
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    80. Bier DM, Brosnan JT, Flatt JP, Hanson RW, Heird W, Hellerstein MK, Jéquier E, Kalhan S, Koletzko B, Macdonald I, Owen O, Uauy R. Report of the IDECG Working Group on lower and upper limits of carbohydrate and fat intake. International Dietary Energy Consultative Group. Eur J Clin Nutr. 1999 Apr; 53 Suppl 1:S177-8. PMID: 10365996.
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    81. Brosnan JT. Comments on metabolic needs for glucose and the role of gluconeogenesis. Eur J Clin Nutr. 1999 Apr; 53 Suppl 1:S107-11. PMID: 10365987.
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    82. House JD, Jacobs RL, Stead LM, Brosnan ME, Brosnan JT. Regulation of homocysteine metabolism. Adv Enzyme Regul. 1999; 39:69-91. PMID: 10470367.
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    83. Jacobs RL, House JD, Brosnan ME, Brosnan JT. Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism in the rat. Diabetes. 1998 Dec; 47(12):1967-70. PMID: 9836532.
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    84. House JD, Brosnan ME, Brosnan JT. Renal uptake and excretion of homocysteine in rats with acute hyperhomocysteinemia. Kidney Int. 1998 Nov; 54(5):1601-7. PMID: 9844136.
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    85. Mabrouk GM, Jois M, Brosnan JT. Cell signalling and the hormonal stimulation of the hepatic glycine cleavage enzyme system by glucagon. Biochem J. 1998 Mar 01; 330 ( Pt 2):759-63. PMID: 9480887.
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    86. O'sullivan D, Brosnan JT, Brosnan ME. Hepatic zonation of the catabolism of arginine and ornithine in the perfused rat liver. Biochem J. 1998 Mar 01; 330 ( Pt 2):627-32. PMID: 9480868.
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    87. Squires SA, Ewart HS, McCarthy C, Brosnan ME, Brosnan JT. Regulation of hepatic glutaminase in the streptozotocin-induced diabetic rat. Diabetes. 1997 Dec; 46(12):1945-9. PMID: 9392478.
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    88. House JD, Brosnan ME, Brosnan JT. Characterization of homocysteine metabolism in the rat kidney. Biochem J. 1997 Nov 15; 328 ( Pt 1):287-92. PMID: 9359866.
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    89. Mabrouk GM, Brosnan JT. Activation of the hepatic glycine cleavage enzyme system by glucagon and glucagon-related peptides. Can J Physiol Pharmacol. 1997 Sep; 75(9):1096-100. PMID: 9365819.
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    90. Brosnan JT, Brosnan ME, Charron R, Nissim I. Incorporation of 15N-labelled precursors into urea isotopomers. Contrib Nephrol. 1997; 121:156-62. PMID: 9336711.
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    91. House JD, Brosnan ME, Brosnan JT. Renal homocysteine metabolism. Contrib Nephrol. 1997; 121:79-84. PMID: 9336701.
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    92. Nissim I, Yudkoff M, Brosnan JT. Regulation of [15N]urea synthesis from [5-15N]glutamine. Role of pH, hormones, and pyruvate. J Biol Chem. 1996 Dec 06; 271(49):31234-42. PMID: 8940126.
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    93. O'Sullivan D, Brosnan JT, Brosnan ME. Catabolism of arginine and ornithine in perfused rat liver; localisation and regulation. Biochem Soc Trans. 1996 Aug; 24(3):488S. PMID: 8879032.
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    94. Brosnan JT, Brosnan ME, Charron R, Nissim I. A mass isotopomer study of urea and glutamine synthesis from 15N-labeled ammonia in the perfused rat liver. J Biol Chem. 1996 Jul 05; 271(27):16199-207. PMID: 8663091.
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    95. Qian D, Brosnan JT. Administration of Escherichia coli endotoxin to rat increases liver mass and hepatocyte volume in vivo. Biochem J. 1996 Jan 15; 313 ( Pt 2):479-86. PMID: 8573081.
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    96. Brosnan JT, Hall B, Selhub J, Nadeau MR, Bostom AG. Renal metabolism of homocysteine in vivo. Biochem Soc Trans. 1995 Aug; 23(3):470S. PMID: 8566366.
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    97. Ewart HS, Qian D, Brosnan JT. Activation of hepatic glutaminase in the endotoxin-treated rat. J Surg Res. 1995 Aug; 59(2):245-9. PMID: 7637340.
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    98. Bostom A, Brosnan JT, Hall B, Nadeau MR, Selhub J. Net uptake of plasma homocysteine by the rat kidney in vivo. Atherosclerosis. 1995 Jul; 116(1):59-62. PMID: 7488333.
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    99. Kovacevic Z, Day SH, Collett V, Brosnan JT, Brosnan ME. Activation of hepatic glutaminase by spermine. Biochem J. 1995 Feb 01; 305 ( Pt 3):837-41. PMID: 7848284.
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    100. Brosnan JT, Ewart HS, Squires SA. Hormonal control of hepatic glutaminase. Adv Enzyme Regul. 1995; 35:131-46. PMID: 7572340.
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    101. Brosnan JT, Qian D. Endotoxin-induced increase in liver mass and hepatocyte volume. Biochem Soc Trans. 1994 May; 22(2):529-32. PMID: 7958360.
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    102. Brosnan JT, Ewart HS, Squires SA, Day SH, Kovacevic Z, Brosnan ME. Hormonal and dietary control of hepatic glutamine catabolism. Contrib Nephrol. 1994; 110:109-14. PMID: 7956241.
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    103. Ewart HS, Brosnan JT. Rapid activation of hepatic glutaminase in rats fed on a single high-protein meal. Biochem J. 1993 Jul 15; 293 ( Pt 2):339-44. PMID: 8343112.
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    104. Dhanakoti SN, Brosnan JT, Brosnan ME, Herzberg GR. Net renal arginine flux in rats is not affected by dietary arginine or dietary protein intake. J Nutr. 1992 May; 122(5):1127-34. PMID: 1564565.
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    105. Ewart HS, Jois M, Brosnan JT. Rapid stimulation of the hepatic glycine-cleavage system in rats fed on a single high-protein meal. Biochem J. 1992 Apr 15; 283 ( Pt 2):441-7. PMID: 1575689.
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    106. Jois M, Ewart HS, Brosnan JT. Regulation of glycine catabolism in rat liver mitochondria. Biochem J. 1992 Apr 15; 283 ( Pt 2):435-9. PMID: 1575688.
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    107. Jungas RL, Halperin ML, Brosnan JT. Quantitative analysis of amino acid oxidation and related gluconeogenesis in humans. Physiol Rev. 1992 Apr; 72(2):419-48. PMID: 1557428.
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    108. Dhanakoti SN, Brosnan ME, Herzberg GR, Brosnan JT. Cellular and subcellular localization of enzymes of arginine metabolism in rat kidney. Biochem J. 1992 Mar 01; 282 ( Pt 2):369-75. PMID: 1312326.
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    109. Wu GY, Brosnan JT. Macrophages can convert citrulline into arginine. Biochem J. 1992 Jan 01; 281 ( Pt 1):45-8. PMID: 1731766.
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    110. Dhanakoti SN, Brosnan JT, Herzberg GR, Brosnan ME. Renal arginine synthesis: studies in vitro and in vivo. Am J Physiol. 1990 Sep; 259(3 Pt 1):E437-42. PMID: 1975989.
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    111. Jois M, Hall B, Collett VM, Brosnan JT. Flux through glycine cleavage system in isolated hepatocytes: effects of glucagon, cAMP, and calcium. Biochem Cell Biol. 1990 Feb; 68(2):543-6. PMID: 2160835.
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    112. Jois M, Hall B, Brosnan JT. Stimulation of glycine catabolism in isolated perfused rat liver by calcium mobilizing hormones and in isolated rat liver mitochondria by submicromolar concentrations of calcium. J Biol Chem. 1990 Jan 25; 265(3):1246-8. PMID: 1688557.
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    113. Letto J, Brosnan JT, Brosnan ME. Oxidation of 2-oxoisocaproate and 2-oxoisovalerate by the perfused rat heart. Interactions with fatty acid oxidation. Biochem Cell Biol. 1990 Jan; 68(1):260-5. PMID: 2112400.
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    114. Brosnan JT, Hall B. Renal serine production in vivo: effects of dietary manipulation of serine status. Can J Physiol Pharmacol. 1989 Sep; 67(9):1058-61. PMID: 2513109.
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    115. Jois M, Hall B, Fewer K, Brosnan JT. Regulation of hepatic glycine catabolism by glucagon. J Biol Chem. 1989 Feb 25; 264(6):3347-51. PMID: 2536745.
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    116. Herzberg GR, Brosnan JT, Hall B, Rogerson M. Gluconeogenesis in liver and kidney of common murre (Uria aalge). Am J Physiol. 1988 Jun; 254(6 Pt 2):R903-7. PMID: 3381915.
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    117. Jois M, Hall DE, Brosnan JT. Serine synthesis by the rat kidney. Contrib Nephrol. 1988; 63:136-40. PMID: 2461272.
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    118. Brosnan JT. The 1986 Borden award lecture. The role of the kidney in amino acid metabolism and nutrition. Can J Physiol Pharmacol. 1987 Dec; 65(12):2355-62. PMID: 3329568.
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    119. Brosnan JT, Lowry M, Vinay P, Gougoux A, Halperin ML. Renal ammonium production--une vue canadienne. Can J Physiol Pharmacol. 1987 Apr; 65(4):489-98. PMID: 3300906.
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    120. Forsey RG, Reid K, Brosnan JT. Competition between fatty acids and carbohydrate or ketone bodies as metabolic fuels for the isolated perfused heart. Can J Physiol Pharmacol. 1987 Mar; 65(3):401-6. PMID: 3107785.
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    121. Lowry M, Hall DE, Hall MS, Brosnan JT. Renal metabolism of amino acids in vivo: studies on serine and glycine fluxes. Am J Physiol. 1987 Feb; 252(2 Pt 2):F304-9. PMID: 2880513.
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    122. Tinker DA, Brosnan JT, Herzberg GR. Interorgan metabolism of amino acids, glucose, lactate, glycerol and uric acid in the domestic fowl (Gallus domesticus). Biochem J. 1986 Dec 15; 240(3):829-36. PMID: 3827871.
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    123. Letto J, Brosnan ME, Brosnan JT. Valine metabolism. Gluconeogenesis from 3-hydroxyisobutyrate. Biochem J. 1986 Dec 15; 240(3):909-12. PMID: 3827880.
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    124. Brosnan ME, Lowry A, Brosnan JT. Diabetes increases active fraction of branched-chain 2-oxoacid dehydrogenase in rat brain. Diabetes. 1986 Sep; 35(9):1041-3. PMID: 3743906.
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    125. Lowry M, Hall DE, Brosnan JT. Serine synthesis in rat kidney: studies with perfused kidney and cortical tubules. Am J Physiol. 1986 Apr; 250(4 Pt 2):F649-58. PMID: 3083696.
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    126. Lanctin H, Brosnan JT, Ross BD. Glutamine synthesis in the perfused rat kidney and in isolated rat cortical tubules: regulation by pH. Clin Sci (Lond). 1985 Dec; 69(6):701-7. PMID: 4064580.
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    127. Lowry M, Hall DE, Brosnan JT. Increased activity of renal glycine-cleavage-enzyme complex in metabolic acidosis. Biochem J. 1985 Oct 15; 231(2):477-80. PMID: 3877504.
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    128. Lowry M, Hall DE, Brosnan JT. Hydroxyproline metabolism by the rat kidney: distribution of renal enzymes of hydroxyproline catabolism and renal conversion of hydroxyproline to glycine and serine. Metabolism. 1985 Oct; 34(10):955-61. PMID: 3930916.
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    129. Brosnan ME, Lowry A, Wasi Y, Lowry M, Brosnan JT. Regional and subcellular distribution of enzymes of branched-chain amino acid metabolism in brains of normal and diabetic rats. Can J Physiol Pharmacol. 1985 Oct; 63(10):1234-8. PMID: 4075248.
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    130. Lowry M, Hall DE, Brosnan JT. Metabolism of glycine- and hydroxyproline-containing peptides by the isolated perfused rat kidney. Biochem J. 1985 Jul 15; 229(2):545-9. PMID: 4038280.
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    131. Lowry M, Hall B, Hall DE, Brosnan JT. Pathways of serine synthesis in the rat kidney. Contrib Nephrol. 1985; 47:203-8. PMID: 3933908.
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    132. Lanctin H, Quarcoo ET, Brosnan JT. Acute regulation of renal glutamine synthesis by pH in rat and guinea pig. Contrib Nephrol. 1985; 47:186-90. PMID: 4064692.
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    133. Brosnan JT, Forsey RG, Brosnan ME. Uptake of tyrosine and leucine in vivo by brain of diabetic and control rats. Am J Physiol. 1984 Nov; 247(5 Pt 1):C450-3. PMID: 6496727.
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    134. Brosnan JT, Man KC, Hall DE, Colbourne SA, Brosnan ME. Interorgan metabolism of amino acids in streptozotocin-diabetic ketoacidotic rat. Am J Physiol. 1983 Feb; 244(2):E151-8. PMID: 6401931.
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    135. Squires EJ, Brosnan JT. Measurements of the turnover rate of glutamine in normal and acidotic rats. Biochem J. 1983 Jan 15; 210(1):277-80. PMID: 6847647.
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    136. Tinker DA, Brosnan JT, Herzberg GR. Phosphoenolpyruvate carboxykinase is a nuclear enzyme in rats and chickens. Int J Biochem. 1983; 15(12):1473-5. PMID: 6653865.
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    137. Epstein FH, Brosnan JT, Tange JD, Ross BD. Improved function with amino acids in the isolated perfused kidney. Am J Physiol. 1982 Sep; 243(3):F284-92. PMID: 7114258.
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    138. Man KC, Brosnan JT. Inhibition of medium and short-chain fatty acid oxidation in rat heart mitochondria by dichloroacetate. Metabolism. 1982 Jul; 31(7):744-8. PMID: 7087796.
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    139. Coolbear KP, Herzberg GR, Brosnan JT. Subcellular localization of chicken liver xanthine dehydrogenase. A possible source of cytoplasmic reducing equivalents. Biochem J. 1982 Feb 15; 202(2):555-8. PMID: 6953967.
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    140. Brosnan JT, Parry DM. Accelerated recovery from metabolic acidosis. Contrib Nephrol. 1982; 31:135-9. PMID: 6286248.
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    141. Brosnan JT. Pathways of carbon flux in gluconeogenesis. Fed Proc. 1982 Jan; 41(1):91-5. PMID: 7056402.
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    142. Parry DM, Hall B, Brosnan JT. Renal metabolite concentrations and the activities of glutaminase and glutamate dehydrogenase during recovery from metabolic acidosis in the rat. Can J Biochem. 1981 Nov-Dec; 59(11-12):871-6. PMID: 7332866.
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    143. Man KC, Hall B, Brosnan JT. Effect of 3-aminopicolinic acid on renal ammoniagenesis in the rat. Biochem Pharmacol. 1981 Jul 15; 30(14):1895-900. PMID: 7271880.
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    144. Brosnan JT, McPhee P, Hall B, Parry DM. Renal glutamine metabolism in rats fed high-protein diets. Am J Physiol. 1978 Sep; 235(3):E261-5. PMID: 696820.
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    145. Parry DM, Brosnan JT. Glutamine metabolism in the kidney during induction of, and recovery from, metabolic acidosis in the rat. Biochem J. 1978 Aug 15; 174(2):387-96. PMID: 708390.
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    146. Brosnan JT, Hall B. The transport and metabolism of glutamine by kidney-cortex mitochondria from normal and acidotic rats. Biochem J. 1977 May 15; 164(2):331-7. PMID: 560188.
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    147. Brosnan JT, McPhee P. Adaptations in glutamine metabolism in kidneys from rats fed on a high-protein diet [proceedings]. Biochem Soc Trans. 1977; 5(6):1766-7. PMID: 598593.
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    148. Squires EJ, Hall DE, Brosnan JT. Arteriovenous differences for amino acids and lactate across kidneys of normal and acidotic rats. Biochem J. 1976 Oct 15; 160(1):125-8. PMID: 1008842.
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    149. Kalra J, Brosnan JT. Localization of phosphate-independent glutaminase in the brush border of rat kidney cortex. Can J Biochem. 1974 Sep; 52(9):762-6. PMID: 4371928.
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    150. Kalra J, Brosnan JT. The subcellular localization of glutaminase isoenzymes in rat kidney cortex. J Biol Chem. 1974 May 25; 249(10):3255-60. PMID: 4364419.
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    151. Brosnan JT, Williamson DH. Mechanisms for the formation of alanine and aspartate on rat liver in vivo after administration of ammonium chloride. Biochem J. 1974 Mar; 138(3):453-62. PMID: 4154744.
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    152. Kalra J, Brosnan JT. Localization of glutaminase in rat liver. FEBS Lett. 1973 Dec 01; 37(2):325-8. PMID: 4148693.
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    153. Brosnan JT, Kopec B, Fritz IB. The localization of carnitine palmitoyltransferase on the inner membrane of bovine liver mitochondria. J Biol Chem. 1973 Jun 10; 248(11):4075-82. PMID: 4708101.
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    154. Brosnan JT, Fritz IB. The permeability of mitochondria to carnitine and acetylcarnitine. Biochem J. 1971 Dec; 125(4):94P-95P. PMID: 5144261.
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    155. Hems DA, Brosnan JT. Effects of metabolic acidosis and starvation on the content of intermediary metabolites in rat kidney. Biochem J. 1971 Jul; 123(3):391-7. PMID: 5126092.
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    156. Hems DA, Brosnan JT. Effects of ischaemia on content of metabolites in rat liver and kidney in vivo. Biochem J. 1970 Nov; 120(1):105-11. PMID: 4321927.
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    157. Brosnan JT, Krebs HA, Williamson DH. Effects of ischaemia on metabolite concentrations in rat liver. Biochem J. 1970 Mar; 117(1):91-6. PMID: 4316090.
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    158. Brosnan JT, Krebs HA, Williamson DH. Removal of ammonia by formation of amino acids in rat liver. Biochem J. 1967 Sep; 104(3):43P-44P. PMID: 6049873.
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