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JOEL L MOAKE

TitleProfessor Emeritus
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
DivisionMedicine-Hematology & Oncology
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    R01HL035387     (MOAKE, JOEL L)Apr 1, 1986 - Mar 31, 1991
    NIH/NHLBI
    VON WILLEBRAND FACTOR AND THE PATHOPHYSIOLOGY OF TTP
    Role: Principal Investigator

    C06HL035337     (MOAKE, JOEL L)Jul 1, 1986 - Jun 30, 1987
    NIH/NHLBI
    NHLBI SHARED RESEARCH FACILITY
    Role: Principal Investigator

    R01HL054169     (MOAKE, JOEL L)May 1, 1995 - Mar 31, 2000
    NIH/NHLBI
    MOLECULAR MECHANISMS OF PLATELET THROMBOSIS UNDER FLOW
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wijeratne SS, Nolasco L, Li J, Jiang K, Moake JL, Kiang CH. Correlating Conformational Dynamics with the Von Willebrand Factor Reductase Activity of Factor H Using Single Molecule Force Measurements. J Phys Chem B. 2018 11 29; 122(47):10653-10658. PMID: 30351116.
      View in: PubMed
    2. Sartain SE, Turner NA, Moake JL. Brain microvascular endothelial cells exhibit lower activation of the alternative complement pathway than glomerular microvascular endothelial cells. J Biol Chem. 2018 05 11; 293(19):7195-7208. PMID: 29555686.
      View in: PubMed
    3. Michael M, Turner N, Elenberg E, Shaffer LG, Teruya J, Arar M, Hui SK, Smith RJ, Moake J. Deficiency of complement factor H-related proteins and autoantibody-positive hemolytic uremic syndrome in an infant with combined partial deficiencies and autoantibodies to complement factor H and ADAMTS13. Clin Kidney J. 2018 Dec; 11(6):791-796. PMID: 30524124.
      View in: PubMed
    4. Nolasco JG, Nolasco LH, Da Q, Cirlos S, Ruggeri ZM, Moake JL, Cruz MA. Complement Component C3 Binds to the A3 Domain of von Willebrand Factor. TH Open. 2018; 2(3):e338-e345. PMID: 31080944.
      View in: PubMed
    5. Zhou Y, Qin S, Hilton T, Tang L, Cruz M, Hernandez R, Moake JL, Tian Q, Frazier OH, Dong JF, Nascimbene A. Quantification of Von Willebrand Factor Cleavage by adamts-13 in Patients Supported by Left Ventricular Assist Devices. ASAIO J. 2017 Nov/Dec; 63(6):849-853. PMID: 28682993.
      View in: PubMed
    6. Moake JL. A new therapeutic strategy for atypical HUS. Blood. 2017 07 20; 130(3):243-244. PMID: 28729338.
      View in: PubMed
    7. Kremer Hovinga JA, Coppo P, Lämmle B, Moake JL, Miyata T, Vanhoorelbeke K. Thrombotic thrombocytopenic purpura. Nat Rev Dis Primers. 2017 Apr 06; 3:17020. PMID: 28382967.
      View in: PubMed
    8. Nascimbene A, Hilton T, Konkle BA, Moake JL, Frazier OH, Dong JF. von Willebrand factor proteolysis by ADAMTS-13 in patients on left ventricular assist device support. J Heart Lung Transplant. 2017 04; 36(4):477-479. PMID: 28325436.
      View in: PubMed
    9. Nascimbene A, Neelamegham S, Frazier OH, Moake JL, Dong JF. Acquired von Willebrand syndrome associated with left ventricular assist device. Blood. 2016 06 23; 127(25):3133-41. PMID: 27143258.
      View in: PubMed
    10. Wijeratne SS, Li J, Yeh HC, Nolasco L, Zhou Z, Bergeron A, Frey EW, Moake JL, Dong JF, Kiang CH. Single-molecule force measurements of the polymerizing dimeric subunit of von Willebrand factor. Phys Rev E. 2016 Jan; 93(1):012410. PMID: 26871104.
      View in: PubMed
    11. Sartain SE, Turner NA, Moake JL. TNF Regulates Essential Alternative Complement Pathway Components and Impairs Activation of Protein C in Human Glomerular Endothelial Cells. J Immunol. 2016 Jan 15; 196(2):832-45. PMID: 26673143.
      View in: PubMed
    12. Turner NA, Moake JL. Factor VIII Is Synthesized in Human Endothelial Cells, Packaged in Weibel-Palade Bodies and Secreted Bound to ULVWF Strings. PLoS One. 2015; 10(10):e0140740. PMID: 26473492.
      View in: PubMed
    13. Balaoing LR, Post AD, Lin AY, Tseng H, Moake JL, Grande-Allen KJ. Laminin Peptide-Immobilized Hydrogels Modulate Valve Endothelial Cell Hemostatic Regulation. PLoS One. 2015; 10(6):e0130749. PMID: 26090873.
      View in: PubMed
    14. Turner NA, Sartain SE, Hui SK, Moake JL. Regulatory components of the alternative complement pathway in endothelial cell cytoplasm, factor H and factor I, are not packaged in Weibel-Palade bodies. PLoS One. 2015; 10(3):e0121994. PMID: 25803806.
      View in: PubMed
    15. Turner N, Sartain S, Moake J. Ultralarge von Willebrand factor-induced platelet clumping and activation of the alternative complement pathway in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndromes. Hematol Oncol Clin North Am. 2015 Jun; 29(3):509-24. PMID: 26043389.
      View in: PubMed
    16. Turner N, Nolasco L, Nolasco J, Sartain S, Moake J. Thrombotic microangiopathies and the linkage between von Willebrand factor and the alternative complement pathway. Semin Thromb Hemost. 2014 Jul; 40(5):544-50. PMID: 24967890.
      View in: PubMed
    17. Li GW, Rambally S, Kamboj J, Reilly S, Moake JL, Udden MM, Mims MP. Treatment of refractory thrombotic thrombocytopenic purpura with N-acetylcysteine: a case report. Transfusion. 2014 May; 54(5):1221-4. PMID: 24117464.
      View in: PubMed
    18. Lo NC, Turner NA, Cruz MA, Moake J. Interaction of Shiga toxin with the A-domains and multimers of von Willebrand Factor. J Biol Chem. 2013 Nov 15; 288(46):33118-23. PMID: 24097977.
      View in: PubMed
    19. Nolasco L, Nolasco J, Feng S, Afshar-Kharghan V, Moake J. Human complement factor H is a reductase for large soluble von Willebrand factor multimers--brief report. Arterioscler Thromb Vasc Biol. 2013 Nov; 33(11):2524-8. PMID: 24008159.
      View in: PubMed
    20. Turner NA, Moake J. Assembly and activation of alternative complement components on endothelial cell-anchored ultra-large von Willebrand factor links complement and hemostasis-thrombosis. PLoS One. 2013; 8(3):e59372. PMID: 23555663.
      View in: PubMed
    21. Wijeratne SS, Botello E, Yeh HC, Zhou Z, Bergeron AL, Frey EW, Patel JM, Nolasco L, Turner NA, Moake JL, Dong JF, Kiang CH. Mechanical activation of a multimeric adhesive protein through domain conformational change. Phys Rev Lett. 2013 Mar 08; 110(10):108102. PMID: 23521301.
      View in: PubMed
    22. Feng S, Kroll MH, Nolasco L, Moake J, Afshar-Kharghan V. Complement activation in thrombotic microangiopathies. Br J Haematol. 2013 Feb; 160(3):404-6. PMID: 23116127.
      View in: PubMed
    23. Turner N, Nolasco L, Moake J. Generation and breakdown of soluble ultralarge von Willebrand factor multimers. Semin Thromb Hemost. 2012 Feb; 38(1):38-46. PMID: 22314602.
      View in: PubMed
    24. Tsai M, Kita A, Leach J, Rounsevell R, Huang JN, Moake J, Ware RE, Fletcher DA, Lam WA. In vitro modeling of the microvascular occlusion and thrombosis that occur in hematologic diseases using microfluidic technology. J Clin Invest. 2012 Jan; 122(1):408-18. PMID: 22156199.
      View in: PubMed
    25. Chen J, Reheman A, Gushiken FC, Nolasco L, Fu X, Moake JL, Ni H, López JA. N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice. J Clin Invest. 2011 Feb; 121(2):593-603. PMID: 21266777.
      View in: PubMed
    26. Moake J. Platelets in bloom. Blood. 2010 May 06; 115(18):3650-1. PMID: 20448116.
      View in: PubMed
    27. Moake J. Thrombotic thrombocytopenia purpura (TTP) and other thrombotic microangiopathies. Best Pract Res Clin Haematol. 2009 Dec; 22(4):567-76. PMID: 19959109.
      View in: PubMed
    28. Turner NA, Nolasco L, Ruggeri ZM, Moake JL. Endothelial cell ADAMTS-13 and VWF: production, release, and VWF string cleavage. Blood. 2009 Dec 03; 114(24):5102-11. PMID: 19822897.
      View in: PubMed
    29. Moake J. Thrombotic microangiopathies: multimers, metalloprotease, and beyond. Clin Transl Sci. 2009 Oct; 2(5):366-73. PMID: 20443921.
      View in: PubMed
    30. Zakarija A, Kwaan HC, Moake JL, Bandarenko N, Pandey DK, McKoy JM, Yarnold PR, Raisch DW, Winters JL, Raife TJ, Cursio JF, Luu TH, Richey EA, Fisher MJ, Ortel TL, Tallman MS, Zheng XL, Matsumoto M, Fujimura Y, Bennett CL. Ticlopidine- and clopidogrel-associated thrombotic thrombocytopenic purpura (TTP): review of clinical, laboratory, epidemiological, and pharmacovigilance findings (1989-2008). Kidney Int Suppl. 2009 Feb; (112):S20-4. PMID: 19180126.
      View in: PubMed
    31. Zhou Z, Jing H, Tao Z, Choi H, Aboulfatova K, Moake J, Li R, Dong JF. Effects of naturally occurring mutations in CUB-1 domain on synthesis, stability, and activity of ADAMTS-13. Thromb Res. 2009 Jul; 124(3):323-7. PMID: 19027144.
      View in: PubMed
    32. Moake JL. Journey in reverse: TTP from bedside to blood bank to bench. J Clin Apher. 2007 Feb; 22(1):37-49. PMID: 17123314.
      View in: PubMed
    33. Ruutu T, Barosi G, Benjamin RJ, Clark RE, George JN, Gratwohl A, Holler E, Iacobelli M, Kentouche K, Lämmle B, Moake JL, Richardson P, Socié G, Zeigler Z, Niederwieser D, Barbui T. Diagnostic criteria for hematopoietic stem cell transplant-associated microangiopathy: results of a consensus process by an International Working Group. Haematologica. 2007 Jan; 92(1):95-100. PMID: 17229640.
      View in: PubMed
    34. Auton M, Cruz MA, Moake J. Conformational stability and domain unfolding of the Von Willebrand factor A domains. J Mol Biol. 2007 Feb 23; 366(3):986-1000. PMID: 17187823.
      View in: PubMed
    35. Kumar RA, Moake JL, Nolasco L, Bergeron AL, Sun C, Dong JF, McIntire LV. Enhanced platelet adhesion and aggregation by endothelial cell-derived unusually large multimers of von Willebrand factor. Biorheology. 2006; 43(5):681-91. PMID: 17047284.
      View in: PubMed
    36. Tao Z, Peng Y, Nolasco L, Cal S, Lopez-Otin C, Li R, Moake JL, López JA, Dong JF. Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions. Blood. 2005 Dec 15; 106(13):4139-45. PMID: 16141351.
      View in: PubMed
    37. Nolasco LH, Turner NA, Bernardo A, Tao Z, Cleary TG, Dong JF, Moake JL. Hemolytic uremic syndrome-associated Shiga toxins promote endothelial-cell secretion and impair ADAMTS13 cleavage of unusually large von Willebrand factor multimers. Blood. 2005 Dec 15; 106(13):4199-209. PMID: 16131569.
      View in: PubMed
    38. Li F, Li CQ, Moake JL, López JA, McIntire LV. Shear stress-induced binding of large and unusually large von Willebrand factor to human platelet glycoprotein Ibalpha. Ann Biomed Eng. 2004 Jul; 32(7):961-9. PMID: 15298433.
      View in: PubMed
    39. Sadler JE, Moake JL, Miyata T, George JN. Recent advances in thrombotic thrombocytopenic purpura. Hematology Am Soc Hematol Educ Program. 2004; 407-23. PMID: 15561695.
      View in: PubMed
    40. Moake JL. Thrombotic thrombocytopenic purpura: survival by "giving a dam". Trans Am Clin Climatol Assoc. 2004; 115:201-19. PMID: 17060968.
      View in: PubMed
    41. Moake JL. von Willebrand factor, ADAMTS-13, and thrombotic thrombocytopenic purpura. Semin Hematol. 2004 Jan; 41(1):4-14. PMID: 14727254.
      View in: PubMed
    42. Padilla A, Moake JL, Bernardo A, Ball C, Wang Y, Arya M, Nolasco L, Turner N, Berndt MC, Anvari B, López JA, Dong JF. P-selectin anchors newly released ultralarge von Willebrand factor multimers to the endothelial cell surface. Blood. 2004 Mar 15; 103(6):2150-6. PMID: 14630802.
      View in: PubMed
    43. Dong JF, Moake JL, Bernardo A, Fujikawa K, Ball C, Nolasco L, López JA, Cruz MA. ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor. J Biol Chem. 2003 Aug 08; 278(32):29633-9. PMID: 12775718.
      View in: PubMed
    44. Horton TM, Stone JD, Yee D, Dreyer Z, Moake JL, Mahoney DH. Case series of thrombotic thrombocytopenic purpura in children and adolescents. J Pediatr Hematol Oncol. 2003 Apr; 25(4):336-9. PMID: 12679653.
      View in: PubMed
    45. Moake JL. Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome. Arch Pathol Lab Med. 2002 Nov; 126(11):1430-3. PMID: 12421153.
      View in: PubMed
    46. Moake JL. Thrombotic microangiopathies. N Engl J Med. 2002 Aug 22; 347(8):589-600. PMID: 12192020.
      View in: PubMed
    47. Dong JF, Moake JL, Nolasco L, Bernardo A, Arceneaux W, Shrimpton CN, Schade AJ, McIntire LV, Fujikawa K, López JA. ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions. Blood. 2002 Dec 01; 100(12):4033-9. PMID: 12393397.
      View in: PubMed
    48. Arya M, Anvari B, Romo GM, Cruz MA, Dong JF, McIntire LV, Moake JL, López JA. Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex: studies using optical tweezers. Blood. 2002 Jun 01; 99(11):3971-7. PMID: 12010796.
      View in: PubMed
    49. Arya M, López JA, Romo GM, Dong JF, McIntire LV, Moake JL, Anvari B. Measurement of the binding forces between von Willebrand factor and variants of platelet glycoprotein Ibalpha using optical tweezers. Lasers Surg Med. 2002; 30(4):306-12. PMID: 11948601.
      View in: PubMed
    50. Li F, Moake JL, McIntire LV. Characterization of von Willebrand factor interaction with collagens in real time using surface plasmon resonance. Ann Biomed Eng. 2002; 30(9):1107-16. PMID: 12502222.
      View in: PubMed
    51. Moake JL. Thrombotic thrombocytopenic purpura: the systemic clumping "plague". Annu Rev Med. 2002; 53:75-88. PMID: 11818464.
      View in: PubMed
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