TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address6701 FANNIN
Houston, TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Poventud-Fuentes I, Garnett E, Despotovic J, Devaraj S. Interference of eltrombopag with bilirubin measurements on the Vitros 5600 analyzer. J Clin Lab Anal. 2021 Jun 19; e23796. PMID: 34145609.
    2. Shimano KA, Neunert C, Bussel JB, Klaassen RJ, Bhat R, Pastore YD, Lambert MP, Bennett CM, Despotovic JM, Forbes P, Grace RF. Quality of life is an important indication for second-line treatment in children with immune thrombocytopenia. Pediatr Blood Cancer. 2021 Jun; 68(6):e29023. PMID: 33764667.
      Citations:    Fields:    
    3. Grimes AB, Kim TO, Kirk SE, Flanagan J, Lambert MP, Grace RF, Despotovic JM. Refractory autoimmune cytopenias in pediatric Evans syndrome with underlying systemic immune dysregulation. Eur J Haematol. 2021 Jun; 106(6):783-787. PMID: 33570766.
      Citations:    Fields:    
    4. Cuker A, Despotovic JM, Grace RF, Kruse C, Lambert MP, Liebman HA, Lyons RM, McCrae KR, Pullarkat V, Wasser JS, Beenhouwer D, Gibbs SN, Yermilov I, Broder MS. Tapering thrombopoietin receptor agonists in primary immune thrombocytopenia: Expert consensus based on the RAND/UCLA modified Delphi panel method. Res Pract Thromb Haemost. 2021 Jan; 5(1):69-80. PMID: 33537531.
    5. Tarantino MD, Despotovic J, Roy J, Grainger J, Cooper N, Beam D, Raj A, Maschan A, Kim J, Eisen M. Romiplostim treatment for children with immune thrombocytopenia: Results of an integrated database of five clinical trials. Pediatr Blood Cancer. 2020 11; 67(11):e28630. PMID: 32902132.
      Citations:    Fields:    Translation:Humans
    6. Kim TO, Grimes AB, Kirk SE, Gilbert MM, Reed HD, Staggers KA, Walker LA, Arulselvan A, Cohen AS, Lambert MP, Despotovic JM. Racial variation in ITP prevalence and chronic disease phenotype suggests biological differences. Blood. 2020 07 30; 136(5):640-643. PMID: 32559763.
      Citations:    Fields:    Translation:Humans
    7. Gilbert MM, Grimes AB, Kim TO, Despotovic JM. Romiplostim for the Treatment of Immune Thrombocytopenia: Spotlight on Patient Acceptability and Ease of Use. Patient Prefer Adherence. 2020; 14:1237-1250. PMID: 32801654.
    8. Al-Samkari H, van Beers EJ, Morton DH, Barcellini W, Eber SW, Glader B, Yaish HM, Chonat S, Kuo KHM, Kollmar N, Despotovic JM, Pospíšilová D, Knoll CM, Kwiatkowski JL, Pastore YD, Thompson AA, Wlodarski MW, Ravindranath Y, Rothman JA, Wang H, Holzhauer S, Breakey VR, Verhovsek MM, Kunz J, Sheth S, Sharma M, Rose MJ, Bradeen HA, McNaull MN, Addonizio K, Al-Sayegh H, London WB, Grace RF. Characterization of the severe phenotype of pyruvate kinase deficiency. Am J Hematol. 2020 Jul 03. PMID: 32619047.
      Citations:    Fields:    
    9. Cirasino L, Robino AM, Podda G, Andrès E, Despotovic JM, Elalfy M, Holbro A, Kondo T, Lambert MP, Loggetto SR, McCrae KR, Lee JW, Cattaneo M. Report of a 'consensus' on the lines of therapy for primary immune thrombocytopenia in adults, promoted by the Italian Gruppo di Studio delle Piastrine. Platelets. 2020 May 18; 31(4):461-473. PMID: 32314933.
      Citations:    Fields:    Translation:Humans
    10. Bianchi P, Fermo E, Lezon-Geyda K, van Beers EJ, Morton HD, Barcellini W, Glader B, Chonat S, Ravindranath Y, Newburger PE, Kollmar N, Despotovic JM, Verhovsek M, Sharma M, Kwiatkowski JL, Kuo KHM, Wlodarski MW, Yaish HM, Holzhauer S, Wang H, Kunz J, Addonizio K, Al-Sayegh H, London WB, Andres O, van Wijk R, Gallagher PG, Grace RFF. Genotype-phenotype correlation and molecular heterogeneity in pyruvate kinase deficiency. Am J Hematol. 2020 05; 95(5):472-482. PMID: 32043619.
      Citations: 9     Fields:    Translation:Humans
    11. Kim TO, Flanagan JM, Habibi A, Arulselvan A, Lambert MP, Grace RF, Despotovic JM. Genetic variants in toll-like receptor 4 are associated with lack of steroid-responsiveness in pediatric ITP patients. Am J Hematol. 2020 04; 95(4):395-400. PMID: 31903617.
      Citations:    Fields:    Translation:Humans
    12. Kirk SE, Grimes AB, Shelke S, Despotovic JM, Powers JM. The cost of a "benign" condition: Healthcare utilization and infectious outcomes in young children with primary autoimmune neutropenia. Pediatr Blood Cancer. 2020 04; 67(4):e28146. PMID: 31886613.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    13. Neunert C, Terrell DR, Arnold DM, Buchanan G, Cines DB, Cooper N, Cuker A, Despotovic JM, George JN, Grace RF, Kühne T, Kuter DJ, Lim W, McCrae KR, Pruitt B, Shimanek H, Vesely SK. American Society of Hematology 2019 guidelines for immune thrombocytopenia. Blood Adv. 2019 12 10; 3(23):3829-3866. PMID: 31794604.
      Citations: 53     Fields:    Translation:Humans
    14. Le Coz C, Bengsch B, Khanna C, Trofa M, Ohtani T, Nolan BE, Henrickson SE, Lambert MP, Kim TO, Despotovic JM, Feldman S, Fadugba OO, Takach P, Ruffner M, Jyonouchi S, Heimall J, Sullivan KE, Wherry EJ, Romberg N. Common variable immunodeficiency-associated endotoxemia promotes early commitment to the T follicular lineage. J Allergy Clin Immunol. 2019 12; 144(6):1660-1673. PMID: 31445098.
      Citations: 5     Fields:    Translation:HumansCellsCTClinical Trials
    15. Ward CM, Andrews RK. Illustrated State-of-the-Art Capsules of the ISTH 2019 Congress in Melbourne, Australia. Res Pract Thromb Haemost. 2019 Jul; 3(3):431-497. PMID: 31294333.
      Citations: 2     
    16. Grace RF, Shimano KA, Bhat R, Neunert C, Bussel JB, Klaassen RJ, Lambert MP, Rothman JA, Breakey VR, Hege K, Bennett CM, Rose MJ, Haley KM, Buchanan GR, Geddis A, Lorenzana A, Jeng M, Pastore YD, Crary SE, Neier M, Neufeld EJ, Neu N, Forbes PW, Despotovic JM. Second-line treatments in children with immune thrombocytopenia: Effect on platelet count and patient-centered outcomes. Am J Hematol. 2019 07; 94(7):741-750. PMID: 30945320.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    17. Kim TO, Despotovic JM. Primary and Secondary Immune Cytopenias: Evaluation and Treatment Approach in Children. Hematol Oncol Clin North Am. 2019 06; 33(3):489-506. PMID: 31030815.
      Citations:    Fields:    Translation:Humans
    18. Tarantino MD, Bussel JB, Blanchette VS, Beam D, Roy J, Despotovic J, Raj A, Carpenter N, Mehta B, Eisen M. Long-term treatment with romiplostim and treatment-free platelet responses in children with chronic immune thrombocytopenia. Haematologica. 2019 11; 104(11):2283-2291. PMID: 30846500.
      Citations: 5     Fields:    Translation:HumansCells
    19. Kim TO, Grimes AB, Kirk S, Arulselvan A, Lambert MP, Grace RF, Despotovic JM. Association of a positive direct antiglobulin test with chronic immune thrombocytopenia and use of second line therapies in children: A multi-institutional review. Am J Hematol. 2019 04; 94(4):461-466. PMID: 30663792.
      Citations: 2     Fields:    Translation:HumansCTClinical Trials
    20. Neunert CE, Despotovic JM. Autoimmune hemolytic anemia and immune thrombocytopenia following hematopoietic stem cell transplant: A critical review of the literature. Pediatr Blood Cancer. 2019 04; 66(4):e27569. PMID: 30537439.
      Citations: 3     Fields:    Translation:Humans
    21. Despotovic JM, Grimes AB. Pediatric ITP: is it different from adult ITP? Hematology Am Soc Hematol Educ Program. 2018 11 30; 2018(1):405-411. PMID: 30504339.
      Citations: 5     Fields:    Translation:Humans
    22. O'Brien SH, Despotovic JM, Neunert CE. Intravenous Immunoglobulin Versus Anti-D Immunoglobulin: When Better Treatment May Not Be the Best Treatment. J Pediatr. 2019 01; 204:11-13. PMID: 30274924.
      Citations:    Fields:    Translation:Humans
    23. van Beers EJ, van Straaten S, Morton DH, Barcellini W, Eber SW, Glader B, Yaish HM, Chonat S, Kwiatkowski JL, Rothman JA, Sharma M, Neufeld EJ, Sheth S, Despotovic JM, Kollmar N, Pospíšilová D, Knoll CM, Kuo K, Pastore YD, Thompson AA, Newburger PE, Ravindranath Y, Wang WC, Wlodarski MW, Wang H, Holzhauer S, Breakey VR, Verhovsek M, Kunz J, McNaull MA, Rose MJ, Bradeen HA, Addonizio K, Li A, Al-Sayegh H, London WB, Grace RF. Prevalence and management of iron overload in pyruvate kinase deficiency: report from the Pyruvate Kinase Deficiency Natural History Study. Haematologica. 2019 02; 104(2):e51-e53. PMID: 30213831.
      Citations: 8     Fields:    Translation:Humans
    24. Hashmi SK, Bergstrom K, Bertuch AA, Despotovic JM, Muscal E, Xia F, Bi W, Marcogliese A, Diaz R. PSTPIP1-associated myeloid-related proteinemia inflammatory syndrome: A rare cause of childhood neutropenia associated with systemic inflammation and hyperzincemia. Pediatr Blood Cancer. 2019 01; 66(1):e27439. PMID: 30198636.
      Citations: 1     Fields:    Translation:Humans
    25. Despotovic JM, Bussel JB. IVIg and Fc?RIIb in kids with ITP: individualizing therapy. Blood. 2018 08 30; 132(9):877-878. PMID: 30166359.
      Citations:    Fields:    Translation:Humans
    26. Grace RF, Despotovic JM, Bennett CM, Bussel JB, Neier M, Neunert C, Crary SE, Pastore YD, Klaassen RJ, Rothman JA, Hege K, Breakey VR, Rose MJ, Shimano KA, Buchanan GR, Geddis A, Haley KM, Lorenzana A, Thompson A, Jeng M, Neufeld EJ, Brown T, Forbes PW, Lambert MP. Physician decision making in selection of second-line treatments in immune thrombocytopenia in children. Am J Hematol. 2018 07; 93(7):882-888. PMID: 29659042.
      Citations: 7     Fields:    Translation:Humans
    27. Grace RF, Bianchi P, van Beers EJ, Eber SW, Glader B, Yaish HM, Despotovic JM, Rothman JA, Sharma M, McNaull MM, Fermo E, Lezon-Geyda K, Morton DH, Neufeld EJ, Chonat S, Kollmar N, Knoll CM, Kuo K, Kwiatkowski JL, Pospíšilová D, Pastore YD, Thompson AA, Newburger PE, Ravindranath Y, Wang WC, Wlodarski MW, Wang H, Holzhauer S, Breakey VR, Kunz J, Sheth S, Rose MJ, Bradeen HA, Neu N, Guo D, Al-Sayegh H, London WB, Gallagher PG, Zanella A, Barcellini W. Clinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study. Blood. 2018 05 17; 131(20):2183-2192. PMID: 29549173.
      Citations: 20     Fields:    Translation:HumansCells
    28. Kim TO, Despotovic J, Lambert MP. Eltrombopag for use in children with immune thrombocytopenia. Blood Adv. 2018 02 27; 2(4):454-461. PMID: 29487060.
      Citations: 19     Fields:    Translation:Humans
    29. Bernhardt MB, De Guzman MM, Grimes A, Kirk S, Nelson S, Bergsbaken J, Minard CG, Despotovic JM. Rapid infusion of rituximab is well tolerated in children with hematologic, oncologic, and rheumatologic disorders. Pediatr Blood Cancer. 2018 Jan; 65(1). PMID: 28792663.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    30. Neunert C, Despotovic J, Haley K, Lambert MP, Nottage K, Shimano K, Bennett C, Klaassen R, Stine K, Thompson A, Pastore Y, Brown T, Forbes PW, Grace RF. Thrombopoietin Receptor Agonist Use in Children: Data From the Pediatric ITP Consortium of North America ICON2 Study. Pediatr Blood Cancer. 2016 08; 63(8):1407-13. PMID: 27135461.
      Citations: 18     Fields:    Translation:Humans
    31. Tarantino MD, Bussel JB, Blanchette VS, Despotovic J, Bennett C, Raj A, Williams B, Beam D, Morales J, Rose MJ, Carpenter N, Nie K, Eisen M. Romiplostim in children with immune thrombocytopenia: a phase 3, randomised, double-blind, placebo-controlled study. Lancet. 2016 Jul 02; 388(10039):45-54. PMID: 27103127.
      Citations: 30     Fields:    Translation:HumansCTClinical Trials
    32. Bussel JB, de Miguel PG, Despotovic JM, Grainger JD, Sevilla J, Blanchette VS, Krishnamurti L, Connor P, David M, Boayue KB, Matthews DC, Lambert MP, Marcello LM, Iyengar M, Chan GW, Chagin KD, Theodore D, Bailey CK, Bakshi KK. Eltrombopag for the treatment of children with persistent and chronic immune thrombocytopenia (PETIT): a randomised, multicentre, placebo-controlled study. Lancet Haematol. 2015 Aug; 2(8):e315-25. PMID: 26688484.
      Citations: 39     Fields:    Translation:Humans
    33. O'Connell AE, Volpi S, Dobbs K, Fiorini C, Tsitsikov E, de Boer H, Barlan IB, Despotovic JM, Espinosa-Rosales FJ, Hanson IC, Kanariou MG, Martínez-Beckerat R, Mayorga-Sirera A, Mejia-Carvajal C, Radwan N, Weiss AR, Pai SY, Lee YN, Notarangelo LD. Next generation sequencing reveals skewing of the T and B cell receptor repertoires in patients with wiskott-Aldrich syndrome. Front Immunol. 2014; 5:340. PMID: 25101082.
      Citations: 23     Fields:    
    34. Thompson JC, Klima J, Despotovic JM, O'Brien SH. Anti-D immunoglobulin therapy for pediatric ITP: before and after the FDA's black box warning. Pediatr Blood Cancer. 2013 Nov; 60(11):E149-51. PMID: 23813881.
      Citations: 3     Fields:    Translation:Humans
    35. Despotovic JM, McGann PT, Smeltzer M, Aygun B, Ware RE. RHD zygosity predicts degree of platelet response to anti-D immune globulin treatment in children with immune thrombocytopenia. Pediatr Blood Cancer. 2013 Sep; 60(9):E106-8. PMID: 23712954.
      Citations: 1     Fields:    Translation:HumansCellsCTClinical Trials
    36. Despotovic JM, Neunert CE. Is anti-D immunoglobulin still a frontline treatment option for immune thrombocytopenia? Hematology Am Soc Hematol Educ Program. 2013; 2013:283-5. PMID: 24319192.
      Citations: 2     Fields:    Translation:Humans
    37. Cook CM, Smeltzer MP, Mortier NA, Kirk SE, Despotovic JM, Ware RE, Hankins JS. The clinical and laboratory spectrum of Hb C [ß6(A3)Glu?Lys, GAG>AAG] disease. Hemoglobin. 2013; 37(1):16-25. PMID: 23297836.
      Citations:    Fields:    Translation:HumansCells
    38. McGann PT, Despotovic JM, Howard TA, Ware RE. A novel laboratory technique demonstrating the influences of RHD zygosity and the RhCcEe phenotype on erythrocyte D antigen expression. Am J Hematol. 2012 Mar; 87(3):266-71. PMID: 22121029.
      Citations: 2     Fields:    Translation:HumansCells
    39. Despotovic JM, Lambert MP, Herman JH, Gernsheimer TB, McCrae KR, Tarantino MD, Bussel JB. RhIG for the treatment of immune thrombocytopenia: consensus and controversy (CME). Transfusion. 2012 May; 52(5):1126-36; quiz 1125. PMID: 21981825.
      Citations: 8     Fields:    Translation:Humans
    40. Ware RE, Despotovic JM, Mortier NA, Flanagan JM, He J, Smeltzer MP, Kimble AC, Aygun B, Wu S, Howard T, Sparreboom A. Pharmacokinetics, pharmacodynamics, and pharmacogenetics of hydroxyurea treatment for children with sickle cell anemia. Blood. 2011 Nov 03; 118(18):4985-91. PMID: 21876119.
      Citations: 47     Fields:    Translation:HumansCTClinical Trials
    41. Despotovic JM, Ware RE. Thrombopoiesis: new ITP paradigm? Blood. 2011 Jul 07; 118(1):1-2. PMID: 21737604.
      Citations: 1     Fields:    Translation:Humans
    42. McGann PT, McDade J, Mortier NA, Combs MR, Ware RE. IgA-mediated autoimmune hemolytic anemia in an infant. Pediatr Blood Cancer. 2011 May; 56(5):837-9. PMID: 21370419.
      Citations: 3     Fields:    Translation:HumansCells
    43. McDade J, Aygun B, Ware RE. Brown recluse spider (Loxosceles reclusa) envenomation leading to acute hemolytic anemia in six adolescents. J Pediatr. 2010 Jan; 156(1):155-7. PMID: 20006769.
      Citations: 8     Fields:    Translation:Humans
    44. McDade J, Abramova T, Mortier N, Howard T, Ware RE. A novel G6PD mutation leading to chronic hemolytic anemia. Pediatr Blood Cancer. 2008 Dec; 51(6):816-9. PMID: 18677765.
      Citations: 3     Fields:    Translation:Humans
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