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Jeffrey L. Noebels

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neurology
DivisionNeurology
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Human Genetics
    DivisionMolecular & Human Genetics

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience


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    R01NS029709     (NOEBELS, JEFFREY)Sep 1, 1991 - Aug 31, 2019
    NIH/NINDS
    Excitability and plasticity in developing epileptic brain
    Role: Principal Investigator

    R01NS040233     (NOEBELS, JEFFREY)Sep 30, 1999 - Jun 30, 2004
    NIH/NINDS
    NEUROPHYSIOLOGY DATABASE OF INBRED MUTANT STRAINS
    Role: Principal Investigator

    R01NS049130     (NOEBELS, JEFFREY)Aug 15, 2004 - May 31, 2010
    NIH/NINDS
    Parallel Sequence Profiling of Ion Channels in Epilepsy
    Role: Principal Investigator

    R25MH076764     (NOEBELS, JEFFREY)Sep 30, 2005 - Aug 31, 2008
    NIH/NIMH
    Course Development in the Neurobiology of Disease
    Role: Principal Investigator

    R25NS054767     (GARDEN, GWENN A)May 1, 2006 - Jan 31, 2016
    NIH/NINDS
    Neurobiology of Disease Workshop -- Teaching Workshop
    Role: Co-Principal Investigator

    P20NS076916     (NOEBELS, JEFFREY)Sep 26, 2011 - Aug 31, 2014
    NIH/NINDS
    PREDICTIVE GENES, MECHANISMS, AND CLINICAL BIOMARKERS OF SUDEP
    Role: Principal Investigator

    U01NS090340     (NOEBELS, JEFFREY)Sep 30, 2014 - Jul 31, 2019
    NIH/NINDS
    SUDEP Research Alliance: Cardiac Gene and Circuit Mechanisms; Application 7 of 7
    Role: Principal Investigator

    U01NS090405     (LHATOO, SAMDEN)Sep 30, 2014 - Jul 31, 2020
    NIH/NINDS
    The Administrative Core of the Center for SUDEP Research
    Role: Co-Principal Investigator

    R21NS088457     (NOEBELS, JEFFREY)May 1, 2015 - Apr 30, 2017
    NIH/NINDS
    In vivo recruitment of neocortical neurons in stargazer absence seizures
    Role: Principal Investigator

    R01CA223388     (NOEBELS, JEFFREY)Dec 15, 2017 - Nov 30, 2022
    NIH/NCI
    MOLECULAR DISSECTION OF SEIZURE MICROENVIRONMENT IN MALIGNANT GLIOMA
    Role: Principal Investigator

    R13NS110308     (NOEBELS, JEFFREY)Sep 30, 2018 - Sep 29, 2019
    NIH/NINDS
    Jasper's Basic Mechanisms of the Epilepsies Workshops
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Miao QL, Herlitze S, Mark MD, Noebels JL. Adult loss of Cacna1a in mice recapitulates childhood absence epilepsy by distinct thalamic bursting mechanisms. Brain. 2020 01 01; 143(1):161-174. PMID: 31800012.
      View in: PubMed
    2. Noebels JL. Predicting the impact of sodium channel mutations in human brain disease. Epilepsia. 2019 Dec; 60 Suppl 3:S8-S16. PMID: 31904123.
      View in: PubMed
    3. Chen CJ, Sgritta M, Mays J, Zhou H, Lucero R, Park J, Wang IC, Park JH, Kaipparettu BA, Stoica L, Jafar-Nejad P, Rigo F, Chin J, Noebels JL, Costa-Mattioli M. Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency. Nat Med. 2019 11; 25(11):1684-1690. PMID: 31636454.
      View in: PubMed
    4. Mahoney JM, Mills JD, Muhlebner A, Noebels J, Potschka H, Simonato M, Kobow K. 2017 WONOEP appraisal: Studying epilepsy as a network disease using systems biology approaches. Epilepsia. 2019 Jun; 60(6):1045-1053. PMID: 31087652.
      View in: PubMed
    5. Noebels JL. Brainstem spreading depolarization: rapid descent into the shadow of SUDEP. Brain. 2019 02 01; 142(2):231-233. PMID: 30698758.
      View in: PubMed
    6. Aiba I, Noebels JL. Adrenergic agonist induces rhythmic firing in quiescent cardiac preganglionic neurons in nucleus ambiguous via activation of intrinsic membrane excitability. J Neurophysiol. 2019 04 01; 121(4):1266-1278. PMID: 30699052.
      View in: PubMed
    7. Ogiwara I, Miyamoto H, Tatsukawa T, Yamagata T, Nakayama T, Atapour N, Miura E, Mazaki E, Ernst SJ, Cao D, Ohtani H, Itohara S, Yanagawa Y, Montal M, Yuzaki M, Inoue Y, Hensch TK, Noebels JL, Yamakawa K. Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice. Commun Biol. 2018; 1:96. PMID: 30175250.
      View in: PubMed
    8. Chen C, Holth JK, Bunton-Stasyshyn R, Anumonwo CK, Meisler MH, Noebels JL, Isom LL. Mapt deletion fails to rescue premature lethality in two models of sodium channel epilepsy. Ann Clin Transl Neurol. 2018 Aug; 5(8):982-987. PMID: 30128323.
      View in: PubMed
    9. Meyer J, Maheshwari A, Noebels J, Smirnakis S. Asynchronous suppression of visual cortex during absence seizures in stargazer mice. Nat Commun. 2018 05 16; 9(1):1938. PMID: 29769525.
      View in: PubMed
    10. Moyer JT, Gnatkovsky V, Ono T, Otáhal J, Wagenaar J, Stacey WC, Noebels J, Ikeda A, Staley K, de Curtis M, Litt B, Galanopoulou AS. Standards for data acquisition and software-based analysis of in vivo electroencephalography recordings from animals. A TASK1-WG5 report of the AES/ILAE Translational Task Force of the ILAE. Epilepsia. 2017 11; 58 Suppl 4:53-67. PMID: 29105070.
      View in: PubMed
    11. Huang CY, Zhang C, Ho TS, Oses-Prieto J, Burlingame AL, Lalonde J, Noebels JL, Leterrier C, Rasband MN. aII Spectrin Forms a Periodic Cytoskeleton at the Axon Initial Segment and Is Required for Nervous System Function. J Neurosci. 2017 11 22; 37(47):11311-11322. PMID: 29038240.
      View in: PubMed
    12. Maheshwari A, Akbar A, Wang M, Marks RL, Yu K, Park S, Foster BL, Noebels JL. Persistent aberrant cortical phase-amplitude coupling following seizure treatment in absence epilepsy models. J Physiol. 2017 12 01; 595(23):7249-7260. PMID: 28901011.
      View in: PubMed
    13. Lam AD, Deck G, Goldman A, Eskandar EN, Noebels J, Cole AJ. Silent hippocampal seizures and spikes identified by foramen ovale electrodes in Alzheimer's disease. Nat Med. 2017 Jun; 23(6):678-680. PMID: 28459436.
      View in: PubMed
    14. Noebels J. Precision physiology and rescue of brain ion channel disorders. J Gen Physiol. 2017 May 01; 149(5):533-546. PMID: 28428202.
      View in: PubMed
    15. John Lin CC, Yu K, Hatcher A, Huang TW, Lee HK, Carlson J, Weston MC, Chen F, Zhang Y, Zhu W, Mohila CA, Ahmed N, Patel AJ, Arenkiel BR, Noebels JL, Creighton CJ, Deneen B. Identification of diverse astrocyte populations and their malignant analogs. Nat Neurosci. 2017 Mar; 20(3):396-405. PMID: 28166219.
      View in: PubMed
    16. Tang M, Gao G, Rueda CB, Yu H, Thibodeaux DN, Awano T, Engelstad KM, Sanchez-Quintero MJ, Yang H, Li F, Li H, Su Q, Shetler KE, Jones L, Seo R, McConathy J, Hillman EM, Noebels JL, De Vivo DC, Monani UR. Brain microvasculature defects and Glut1 deficiency syndrome averted by early repletion of the glucose transporter-1 protein. Nat Commun. 2017 01 20; 8:14152. PMID: 28106060.
      View in: PubMed
    17. Hernandez CC, Klassen TL, Jackson LG, Gurba K, Hu N, Noebels JL, Macdonald RL. Correction: Deleterious Rare Variants Reveal Risk for Loss of GABAA Receptor Function in Patients with Genetic Epilepsy and in the General Population. PLoS One. 2016; 11(11):e0167264. PMID: 27870904.
      View in: PubMed
    18. Hernandez CC, Klassen TL, Jackson LG, Gurba K, Hu N, Noebels JL, Macdonald RL. Deleterious Rare Variants Reveal Risk for Loss of GABAA Receptor Function in Patients with Genetic Epilepsy and in the General Population. PLoS One. 2016; 11(9):e0162883. PMID: 27622563.
      View in: PubMed
    19. Aiba I, Wehrens XH, Noebels JL. Leaky RyR2 channels unleash a brainstem spreading depolarization mechanism of sudden cardiac death. Proc Natl Acad Sci U S A. 2016 08 16; 113(33):E4895-903. PMID: 27482086.
      View in: PubMed
    20. Holmes GL, Noebels JL. The Epilepsy Spectrum: Targeting Future Research Challenges. Cold Spring Harb Perspect Med. 2016 07 01; 6(7). PMID: 27371672.
      View in: PubMed
    21. Noebels J. Hippocampal abnormalities and sudden childhood death. Forensic Sci Med Pathol. 2016 06; 12(2):198-9. PMID: 27094436.
      View in: PubMed
    22. Horváth A, Szucs A, Barcs G, Noebels JL, Kamondi A. Epileptic Seizures in Alzheimer Disease: A Review. Alzheimer Dis Assoc Disord. 2016 Apr-Jun; 30(2):186-92. PMID: 26756385.
      View in: PubMed
    23. Bomben VC, Aiba I, Qian J, Mark MD, Herlitze S, Noebels JL. Isolated P/Q Calcium Channel Deletion in Layer VI Corticothalamic Neurons Generates Absence Epilepsy. J Neurosci. 2016 Jan 13; 36(2):405-18. PMID: 26758833.
      View in: PubMed
    24. Maheshwari A, Marks RL, Yu KM, Noebels JL. Shift in interictal relative gamma power as a novel biomarker for drug response in two mouse models of absence epilepsy. Epilepsia. 2016 Jan; 57(1):79-88. PMID: 26663261.
      View in: PubMed
    25. Noebels JL. Single-Gene Determinants of Epilepsy Comorbidity. Cold Spring Harb Perspect Med. 2015 Nov 02; 5(11). PMID: 26525453.
      View in: PubMed
    26. Siehr MS, Noebels JL. Early rescue of interneuron disease trajectory in developmental epilepsies. Curr Opin Neurobiol. 2016 Feb; 36:82-8. PMID: 26517286.
      View in: PubMed
    27. Lhatoo S, Noebels J, Whittemore V. Sudden unexpected death in epilepsy: Identifying risk and preventing mortality. Epilepsia. 2015 Nov; 56(11):1700-6. PMID: 26494436.
      View in: PubMed
    28. Kole MJ, Qian J, Waase MP, Klassen TL, Chen TT, Augustine GJ, Noebels JL. Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing. J Neurosci. 2015 Aug 12; 35(32):11433-44. PMID: 26269648.
      View in: PubMed
    29. Glasscock E, Voigt N, McCauley MD, Sun Q, Li N, Chiang DY, Zhou XB, Molina CE, Thomas D, Schmidt C, Skapura DG, Noebels JL, Dobrev D, Wehrens XH. Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation. Basic Res Cardiol. 2015 Sep; 110(5):505. PMID: 26162324.
      View in: PubMed
    30. Aiba I, Noebels JL. Spreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP models. Sci Transl Med. 2015 Apr 08; 7(282):282ra46. PMID: 25855492.
      View in: PubMed
    31. Noebels J. Pathway-driven discovery of epilepsy genes. Nat Neurosci. 2015 Mar; 18(3):344-50. PMID: 25710836.
      View in: PubMed
    32. Qi Y, Wang J, Bomben VC, Li DP, Chen SR, Sun H, Xi Y, Reed JG, Cheng J, Pan HL, Noebels JL, Yeh ET. Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death. Neuron. 2014 Sep 03; 83(5):1159-71. PMID: 25189211.
      View in: PubMed
    33. Nakao A, Miki T, Shimono K, Oka H, Numata T, Kiyonaka S, Matsushita K, Ogura H, Niidome T, Noebels JL, Wakamori M, Imoto K, Mori Y. Compromised maturation of GABAergic inhibition underlies abnormal network activity in the hippocampus of epileptic Ca2+ channel mutant mice, tottering. Pflugers Arch. 2015 Apr; 467(4):737-52. PMID: 24947601.
      View in: PubMed
    34. Ozkan ED, Creson TK, Kramár EA, Rojas C, Seese RR, Babyan AH, Shi Y, Lucero R, Xu X, Noebels JL, Miller CA, Lynch G, Rumbaugh G. Reduced cognition in Syngap1 mutants is caused by isolated damage within developing forebrain excitatory neurons. Neuron. 2014 Jun 18; 82(6):1317-33. PMID: 24945774.
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    35. Bomben V, Holth J, Reed J, Cramer P, Landreth G, Noebels J. Bexarotene reduces network excitability in models of Alzheimer's disease and epilepsy. Neurobiol Aging. 2014 Sep; 35(9):2091-5. PMID: 24767949.
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    36. Born HA, Kim JY, Savjani RR, Das P, Dabaghian YA, Guo Q, Yoo JW, Schuler DR, Cirrito JR, Zheng H, Golde TE, Noebels JL, Jankowsky JL. Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease. J Neurosci. 2014 Mar 12; 34(11):3826-40. PMID: 24623762.
      View in: PubMed
    37. Olivetti PR, Maheshwari A, Noebels JL. Neonatal estradiol stimulation prevents epilepsy in Arx model of X-linked infantile spasms syndrome. Sci Transl Med. 2014 Jan 22; 6(220):220ra12. PMID: 24452264.
      View in: PubMed
    38. Guerrini R, Noebels J. How can advances in epilepsy genetics lead to better treatments and cures? Adv Exp Med Biol. 2014; 813:309-17. PMID: 25012387.
      View in: PubMed
    39. Maheshwari A, Noebels JL. Monogenic models of absence epilepsy: windows into the complex balance between inhibition and excitation in thalamocortical microcircuits. Prog Brain Res. 2014; 213:223-52. PMID: 25194492.
      View in: PubMed
    40. Klassen TL, Bomben VC, Patel A, Drabek J, Chen TT, Gu W, Zhang F, Chapman K, Lupski JR, Noebels JL, Goldman AM. High-resolution molecular genomic autopsy reveals complex sudden unexpected death in epilepsy risk profile. Epilepsia. 2014 Feb; 55(2):e6-12. PMID: 24372310.
      View in: PubMed
    41. Maheshwari A, Nahm WK, Noebels JL. Paradoxical proepileptic response to NMDA receptor blockade linked to cortical interneuron defect in stargazer mice. Front Cell Neurosci. 2013; 7:156. PMID: 24065886.
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    42. Wilcox KS, Dixon-Salazar T, Sills GJ, Ben-Menachem E, White HS, Porter RJ, Dichter MA, Moshé SL, Noebels JL, Privitera MD, Rogawski MA. Issues related to development of new antiseizure treatments. Epilepsia. 2013 Aug; 54 Suppl 4:24-34. PMID: 23909851.
      View in: PubMed
    43. Cole AJ, Eskandar E, Mela T, Noebels JL, Gonzalez RG, McGuone D. Case records of the Massachusetts General Hospital. Case 18-2013: a 32-year-old woman with recurrent episodes of altered consciousness. N Engl J Med. 2013 Jun 13; 368(24):2304-12. PMID: 23758236.
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    44. Maejima T, Wollenweber P, Teusner LU, Noebels JL, Herlitze S, Mark MD. Postnatal loss of P/Q-type channels confined to rhombic-lip-derived neurons alters synaptic transmission at the parallel fiber to purkinje cell synapse and replicates genomic Cacna1a mutation phenotype of ataxia and seizures in mice. J Neurosci. 2013 Mar 20; 33(12):5162-74. PMID: 23516282.
      View in: PubMed
    45. Klassen TL, Drabek J, Tomson T, Sveinsson O, von Döbeln U, Noebels JL, Goldman AM. Visual automated fluorescence electrophoresis provides simultaneous quality, quantity, and molecular weight spectra for genomic DNA from archived neonatal blood spots. J Mol Diagn. 2013 May; 15(3):283-90. PMID: 23518217.
      View in: PubMed
    46. Chen TT, Klassen TL, Goldman AM, Marini C, Guerrini R, Noebels JL. Novel brain expression of ClC-1 chloride channels and enrichment of CLCN1 variants in epilepsy. Neurology. 2013 Mar 19; 80(12):1078-85. PMID: 23408874.
      View in: PubMed
    47. Holth JK, Bomben VC, Reed JG, Inoue T, Younkin L, Younkin SG, Pautler RG, Botas J, Noebels JL. Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy. J Neurosci. 2013 Jan 23; 33(4):1651-9. PMID: 23345237.
      View in: PubMed
    48. Eom T, Zhang C, Wang H, Lay K, Fak J, Noebels JL, Darnell RB. NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure. Elife. 2013 Jan 22; 2:e00178. PMID: 23359859.
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    49. Lerche H, Shah M, Beck H, Noebels J, Johnston D, Vincent A. Ion channels in genetic and acquired forms of epilepsy. J Physiol. 2013 Feb 15; 591(4):753-64. PMID: 23090947.
      View in: PubMed
    50. Ince-Dunn G, Okano HJ, Jensen KB, Park WY, Zhong R, Ule J, Mele A, Fak JJ, Yang C, Zhang C, Yoo J, Herre M, Okano H, Noebels JL, Darnell RB. Neuronal Elav-like (Hu) proteins regulate RNA splicing and abundance to control glutamate levels and neuronal excitability. Neuron. 2012 Sep 20; 75(6):1067-80. PMID: 22998874.
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    51. Klassen TL, von Rüden EL, Drabek J, Noebels JL, Goldman AM. Comparative analytical utility of DNA derived from alternative human specimens for molecular autopsy and diagnostics. J Mol Diagn. 2012 Sep; 14(5):451-7. PMID: 22796560.
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    52. Glasscock E, Qian J, Kole MJ, Noebels JL. Transcompartmental reversal of single fibre hyperexcitability in juxtaparanodal Kv1.1-deficient vagus nerve axons by activation of nodal KCNQ channels. J Physiol. 2012 Aug 15; 590(16):3913-26. PMID: 22641786.
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    53. de Curtis M, Nehlig A, Noebels J, Sankar R, Vezzani A. WONOEP XI: Workshop summary by the Scientific Organizing Committee. Epilepsia. 2012 Jul; 53(7):1275-6. PMID: 22578186.
      View in: PubMed
    54. Olivetti PR, Noebels JL. Interneuron, interrupted: molecular pathogenesis of ARX mutations and X-linked infantile spasms. Curr Opin Neurobiol. 2012 Oct; 22(5):859-65. PMID: 22565167.
      View in: PubMed
    55. York B, Reineke EL, Sagen JV, Nikolai BC, Zhou S, Louet JF, Chopra AR, Chen X, Reed G, Noebels J, Adesina AM, Yu H, Wong LJ, Tsimelzon A, Hilsenbeck S, Stevens RD, Wenner BR, Ilkayeva O, Xu J, Newgard CB, O'Malley BW. Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy. Cell Metab. 2012 May 02; 15(5):752-63. PMID: 22560224.
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    56. Galanopoulou AS, Buckmaster PS, Staley KJ, Moshé SL, Perucca E, Engel J, Löscher W, Noebels JL, Pitkänen A, Stables J, White HS, O'Brien TJ, Simonato M. Identification of new epilepsy treatments: issues in preclinical methodology. Epilepsia. 2012 Mar; 53(3):571-82. PMID: 22292566.
      View in: PubMed
    57. Zhu PJ, Huang W, Kalikulov D, Yoo JW, Placzek AN, Stoica L, Zhou H, Bell JC, Friedlander MJ, Krnjevic K, Noebels JL, Costa-Mattioli M. Suppression of PKR promotes network excitability and enhanced cognition by interferon-?-mediated disinhibition. Cell. 2011 Dec 09; 147(6):1384-96. PMID: 22153080.
      View in: PubMed
    58. McGuire AL, Oliver JM, Slashinski MJ, Graves JL, Wang T, Kelly PA, Fisher W, Lau CC, Goss J, Okcu M, Treadwell-Deering D, Goldman AM, Noebels JL, Hilsenbeck SG. To share or not to share: a randomized trial of consent for data sharing in genome research. Genet Med. 2011 Nov; 13(11):948-55. PMID: 21785360.
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    59. Ward CS, Arvide EM, Huang TW, Yoo J, Noebels JL, Neul JL. MeCP2 is critical within HoxB1-derived tissues of mice for normal lifespan. J Neurosci. 2011 Jul 13; 31(28):10359-70. PMID: 21753013.
      View in: PubMed
    60. Klassen T, Davis C, Goldman A, Burgess D, Chen T, Wheeler D, McPherson J, Bourquin T, Lewis L, Villasana D, Morgan M, Muzny D, Gibbs R, Noebels J. Exome sequencing of ion channel genes reveals complex profiles confounding personal risk assessment in epilepsy. Cell. 2011 Jun 24; 145(7):1036-48. PMID: 21703448.
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    61. Shim DJ, Yang L, Reed JG, Noebels JL, Chiao PJ, Zheng H. Disruption of the NF-?B/I?Ba Autoinhibitory Loop Improves Cognitive Performance and Promotes Hyperexcitability of Hippocampal Neurons. Mol Neurodegener. 2011 Jun 10; 6:42. PMID: 21663635.
      View in: PubMed
    62. Mark MD, Maejima T, Kuckelsberg D, Yoo JW, Hyde RA, Shah V, Gutierrez D, Moreno RL, Kruse W, Noebels JL, Herlitze S. Delayed postnatal loss of P/Q-type calcium channels recapitulates the absence epilepsy, dyskinesia, and ataxia phenotypes of genomic Cacna1a mutations. J Neurosci. 2011 Mar 16; 31(11):4311-26. PMID: 21411672.
      View in: PubMed
    63. Roberson ED, Halabisky B, Yoo JW, Yao J, Chin J, Yan F, Wu T, Hamto P, Devidze N, Yu GQ, Palop JJ, Noebels JL, Mucke L. Amyloid-ß/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease. J Neurosci. 2011 Jan 12; 31(2):700-11. PMID: 21228179.
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    64. Qian J, Xu K, Yoo J, Chen TT, Andrews G, Noebels JL. Knockout of Zn transporters Zip-1 and Zip-3 attenuates seizure-induced CA1 neurodegeneration. J Neurosci. 2011 Jan 05; 31(1):97-104. PMID: 21209194.
      View in: PubMed
    65. Noebels J. A perfect storm: Converging paths of epilepsy and Alzheimer's dementia intersect in the hippocampal formation. Epilepsia. 2011 Jan; 52 Suppl 1:39-46. PMID: 21214538.
      View in: PubMed
    66. Noebels JL, Avoli M, Rogawski M, Olsen R, Delgado-Escueta AV. "Jasper's Basic Mechanisms of the Epilepsies" Workshop. Epilepsia. 2010 Dec; 51 Suppl 5:1-5. PMID: 21208201.
      View in: PubMed
    67. Chao HT, Chen H, Samaco RC, Xue M, Chahrour M, Yoo J, Neul JL, Gong S, Lu HC, Heintz N, Ekker M, Rubenstein JL, Noebels JL, Rosenmund C, Zoghbi HY. Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes. Nature. 2010 Nov 11; 468(7321):263-9. PMID: 21068835.
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    68. Peebles CL, Yoo J, Thwin MT, Palop JJ, Noebels JL, Finkbeiner S. Arc regulates spine morphology and maintains network stability in vivo. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):18173-8. PMID: 20921410.
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    69. Jiang YH, Pan Y, Zhu L, Landa L, Yoo J, Spencer C, Lorenzo I, Brilliant M, Noebels J, Beaudet AL. Altered ultrasonic vocalization and impaired learning and memory in Angelman syndrome mouse model with a large maternal deletion from Ube3a to Gabrb3. PLoS One. 2010 Aug 20; 5(8):e12278. PMID: 20808828.
      View in: PubMed
    70. Zhang X, Bertaso F, Yoo JW, Baumgärtel K, Clancy SM, Lee V, Cienfuegos C, Wilmot C, Avis J, Hunyh T, Daguia C, Schmedt C, Noebels J, Jegla T. Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy. Nat Neurosci. 2010 Sep; 13(9):1056-8. PMID: 20676103.
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    71. Glasscock E, Yoo JW, Chen TT, Klassen TL, Noebels JL. Kv1.1 potassium channel deficiency reveals brain-driven cardiac dysfunction as a candidate mechanism for sudden unexplained death in epilepsy. J Neurosci. 2010 Apr 14; 30(15):5167-75. PMID: 20392939.
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    72. Ottman R, Hirose S, Jain S, Lerche H, Lopes-Cendes I, Noebels JL, Serratosa J, Zara F, Scheffer IE. Genetic testing in the epilepsies--report of the ILAE Genetics Commission. Epilepsia. 2010 Apr; 51(4):655-70. PMID: 20100225.
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    73. Price MG, Yoo JW, Burgess DL, Deng F, Hrachovy RA, Frost JD, Noebels JL. A triplet repeat expansion genetic mouse model of infantile spasms syndrome, Arx(GCG)10+7, with interneuronopathy, spasms in infancy, persistent seizures, and adult cognitive and behavioral impairment. J Neurosci. 2009 Jul 08; 29(27):8752-63. PMID: 19587282.
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    74. Ernst WL, Noebels JL. Expanded alternative splice isoform profiling of the mouse Cav3.1/alpha1G T-type calcium channel. BMC Mol Biol. 2009 May 29; 10:53. PMID: 19480703.
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    75. Jacobs MP, Leblanc GG, Brooks-Kayal A, Jensen FE, Lowenstein DH, Noebels JL, Spencer DD, Swann JW. Curing epilepsy: progress and future directions. Epilepsy Behav. 2009 Mar; 14(3):438-45. PMID: 19341977.
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    76. Ernst WL, Zhang Y, Yoo JW, Ernst SJ, Noebels JL. Genetic enhancement of thalamocortical network activity by elevating alpha 1g-mediated low-voltage-activated calcium current induces pure absence epilepsy. J Neurosci. 2009 Feb 11; 29(6):1615-25. PMID: 19211869.
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    77. Ernst SJ, Aguilar-Bryan L, Noebels JL. Sodium channel beta1 regulatory subunit deficiency reduces pancreatic islet glucose-stimulated insulin and glucagon secretion. Endocrinology. 2009 Mar; 150(3):1132-9. PMID: 18988673.
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    78. Shuba YM, Perez-Reyes E, Lory P, Noebels J. T-type calcium channels: from discovery to channelopathies, 25 years of research. Channels (Austin). 2008 Jul-Aug; 2(4):299-302. PMID: 18769138.
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    79. Singh NA, Otto JF, Dahle EJ, Pappas C, Leslie JD, Vilaythong A, Noebels JL, White HS, Wilcox KS, Leppert MF. Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization. J Physiol. 2008 Jul 15; 586(14):3405-23. PMID: 18483067.
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    80. Seal RP, Akil O, Yi E, Weber CM, Grant L, Yoo J, Clause A, Kandler K, Noebels JL, Glowatzki E, Lustig LR, Edwards RH. Sensorineural deafness and seizures in mice lacking vesicular glutamate transporter 3. Neuron. 2008 Jan 24; 57(2):263-75. PMID: 18215623.
      View in: PubMed
    81. Noebels JL. 2006 Merritt Putnam Symposium: mapping epileptic circuitry. Epilepsia. 2008; 49 Suppl 3:1-2. PMID: 18304250.
      View in: PubMed
    82. Glasscock E, Qian J, Yoo JW, Noebels JL. Masking epilepsy by combining two epilepsy genes. Nat Neurosci. 2007 Dec; 10(12):1554-8. PMID: 17982453.
      View in: PubMed
    83. Palop JJ, Chin J, Roberson ED, Wang J, Thwin MT, Bien-Ly N, Yoo J, Ho KO, Yu GQ, Kreitzer A, Finkbeiner S, Noebels JL, Mucke L. Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease. Neuron. 2007 Sep 06; 55(5):697-711. PMID: 17785178.
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    84. Lopez-Santiago LF, Meadows LS, Ernst SJ, Chen C, Malhotra JD, McEwen DP, Speelman A, Noebels JL, Maier SK, Lopatin AN, Isom LL. Sodium channel Scn1b null mice exhibit prolonged QT and RR intervals. J Mol Cell Cardiol. 2007 Nov; 43(5):636-47. PMID: 17884088.
      View in: PubMed
    85. Sisodiya S, Cross JH, Blümcke I, Chadwick D, Craig J, Crino PB, Debenham P, Delanty N, Elmslie F, Gardiner M, Golden J, Goldstein D, Greenberg DA, Guerrini R, Hanna M, Harris J, Harrison P, Johnson MR, Kirov G, Kullman DM, Makoff A, Marini C, Nabbout R, Nashef L, Noebels JL, Ottman R, Pirmohamed M, Pitkänen A, Scheffer I, Shorvon S, Sills G, Wood N, Zuberi S. Genetics of epilepsy: epilepsy research foundation workshop report. Epileptic Disord. 2007 Jun; 9(2):194-236. PMID: 17525034.
      View in: PubMed
    86. Bi W, Yan J, Shi X, Yuva-Paylor LA, Antalffy BA, Goldman A, Yoo JW, Noebels JL, Armstrong DL, Paylor R, Lupski JR. Rai1 deficiency in mice causes learning impairment and motor dysfunction, whereas Rai1 heterozygous mice display minimal behavioral phenotypes. Hum Mol Genet. 2007 Aug 01; 16(15):1802-13. PMID: 17517686.
      View in: PubMed
    87. Noebels JL. The Judith Hoyer Lecture: genes, pixels, patterns, and prevention. Epilepsy Behav. 2006 Nov; 9(3):379-85. PMID: 17029973.
      View in: PubMed
    88. Goldman A, Noebels J. Invited comments on the Shostak and Ottman review. Epilepsia. 2006 Oct; 47(10):1750-1; author reply 1755-6. PMID: 17054704.
      View in: PubMed
    89. Qian J, Noebels JL. Exocytosis of vesicular zinc reveals persistent depression of neurotransmitter release during metabotropic glutamate receptor long-term depression at the hippocampal CA3-CA1 synapse. J Neurosci. 2006 May 31; 26(22):6089-95. PMID: 16738253.
      View in: PubMed
    90. Wang D, Pascual JM, Yang H, Engelstad K, Mao X, Cheng J, Yoo J, Noebels JL, De Vivo DC. A mouse model for Glut-1 haploinsufficiency. Hum Mol Genet. 2006 Apr 01; 15(7):1169-79. PMID: 16497725.
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    91. Goldman AM, Potocki L, Walz K, Lynch JK, Glaze DG, Lupski JR, Noebels JL. Epilepsy and chromosomal rearrangements in Smith-Magenis Syndrome [del(17)(p11.2p11.2)]. J Child Neurol. 2006 Feb; 21(2):93-8. PMID: 16566870.
      View in: PubMed
    92. Brenner R, Chen QH, Vilaythong A, Toney GM, Noebels JL, Aldrich RW. BK channel beta4 subunit reduces dentate gyrus excitability and protects against temporal lobe seizures. Nat Neurosci. 2005 Dec; 8(12):1752-9. PMID: 16261134.
      View in: PubMed
    93. Cobos I, Calcagnotto ME, Vilaythong AJ, Thwin MT, Noebels JL, Baraban SC, Rubenstein JL. Mice lacking Dlx1 show subtype-specific loss of interneurons, reduced inhibition and epilepsy. Nat Neurosci. 2005 Aug; 8(8):1059-68. PMID: 16007083.
      View in: PubMed
    94. Qian J, Noebels JL. Visualization of transmitter release with zinc fluorescence detection at the mouse hippocampal mossy fibre synapse. J Physiol. 2005 Aug 01; 566(Pt 3):747-58. PMID: 15919713.
      View in: PubMed
    95. Noebels JL. Calcium channel "gaiting" and absence epilepsy. Epilepsy Curr. 2005 May-Jun; 5(3):95-7. PMID: 16145613.
      View in: PubMed
    96. Senechal KR, Thaller C, Noebels JL. ADPEAF mutations reduce levels of secreted LGI1, a putative tumor suppressor protein linked to epilepsy. Hum Mol Genet. 2005 Jun 15; 14(12):1613-20. PMID: 15857855.
      View in: PubMed
    97. Jankovic J, Noebels JL. Genetic mouse models of essential tremor: are they essential? J Clin Invest. 2005 Mar; 115(3):584-6. PMID: 15765140.
      View in: PubMed
    98. May P, Rohlmann A, Bock HH, Zurhove K, Marth JD, Schomburg ED, Noebels JL, Beffert U, Sweatt JD, Weeber EJ, Herz J. Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice. Mol Cell Biol. 2004 Oct; 24(20):8872-83. PMID: 15456862.
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    99. Collins AL, Levenson JM, Vilaythong AP, Richman R, Armstrong DL, Noebels JL, David Sweatt J, Zoghbi HY. Mild overexpression of MeCP2 causes a progressive neurological disorder in mice. Hum Mol Genet. 2004 Nov 01; 13(21):2679-89. PMID: 15351775.
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    100. Zhang Y, Vilaythong AP, Yoshor D, Noebels JL. Elevated thalamic low-voltage-activated currents precede the onset of absence epilepsy in the SNAP25-deficient mouse mutant coloboma. J Neurosci. 2004 Jun 02; 24(22):5239-48. PMID: 15175394.
      View in: PubMed
    101. Chen C, Westenbroek RE, Xu X, Edwards CA, Sorenson DR, Chen Y, McEwen DP, O'Malley HA, Bharucha V, Meadows LS, Knudsen GA, Vilaythong A, Noebels JL, Saunders TL, Scheuer T, Shrager P, Catterall WA, Isom LL. Mice lacking sodium channel beta1 subunits display defects in neuronal excitability, sodium channel expression, and nodal architecture. J Neurosci. 2004 Apr 21; 24(16):4030-42. PMID: 15102918.
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    102. Houseweart MK, Pennacchio LA, Vilaythong A, Peters C, Noebels JL, Myers RM. Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1). J Neurobiol. 2003 Sep 15; 56(4):315-27. PMID: 12918016.
      View in: PubMed
    103. Qian J, Noebels JL. Topiramate alters excitatory synaptic transmission in mouse hippocampus. Epilepsy Res. 2003 Aug; 55(3):225-33. PMID: 12972176.
      View in: PubMed
    104. Noebels JL. Stiff Goats, Chloride Ions, and Idiopathic Generalized Epilepsy (IGE). Epilepsy Curr. 2003 Jul; 3(4):146-147. PMID: 15309062.
      View in: PubMed
    105. Walz K, Caratini-Rivera S, Bi W, Fonseca P, Mansouri DL, Lynch J, Vogel H, Noebels JL, Bradley A, Lupski JR. Modeling del(17)(p11.2p11.2) and dup(17)(p11.2p11.2) contiguous gene syndromes by chromosome engineering in mice: phenotypic consequences of gene dosage imbalance. Mol Cell Biol. 2003 May; 23(10):3646-55. PMID: 12724422.
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    106. Kantheti P, Diaz ME, Peden AE, Seong EE, Dolan DF, Robinson MS, Noebels JL, Burmeister ML. Genetic and phenotypic analysis of the mouse mutant mh2J, an Ap3d allele caused by IAP element insertion. Mamm Genome. 2003 Mar; 14(3):157-67. PMID: 12647238.
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    107. Noebels JL. How a Sodium Channel Mutation Causes Epilepsy. Epilepsy Curr. 2003 Mar; 3(2):70-71. PMID: 15309091.
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    108. Powell EM, Campbell DB, Stanwood GD, Davis C, Noebels JL, Levitt P. Genetic disruption of cortical interneuron development causes region- and GABA cell type-specific deficits, epilepsy, and behavioral dysfunction. J Neurosci. 2003 Jan 15; 23(2):622-31. PMID: 12533622.
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    109. Noebels JL. Exploring new gene discoveries in idiopathic generalized epilepsy. Epilepsia. 2003; 44 Suppl 2:16-21. PMID: 12752457.
      View in: PubMed
    110. Noebels JL. The biology of epilepsy genes. Annu Rev Neurosci. 2003; 26:599-625. PMID: 14527270.
      View in: PubMed
    111. Stables JP, Bertram EH, White HS, Coulter DA, Dichter MA, Jacobs MP, Loscher W, Lowenstein DH, Moshe SL, Noebels JL, Davis M. Models for epilepsy and epileptogenesis: report from the NIH workshop, Bethesda, Maryland. Epilepsia. 2002 Nov; 43(11):1410-20. PMID: 12423393.
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    112. Zhang Y, Mori M, Burgess DL, Noebels JL. Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons. J Neurosci. 2002 Aug 01; 22(15):6362-71. PMID: 12151514.
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    113. Shahbazian M, Young J, Yuva-Paylor L, Spencer C, Antalffy B, Noebels J, Armstrong D, Paylor R, Zoghbi H. Mice with truncated MeCP2 recapitulate many Rett syndrome features and display hyperacetylation of histone H3. Neuron. 2002 Jul 18; 35(2):243-54. PMID: 12160743.
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    114. Noebels JL. A Gene for JME at Last: The alpha1 GABA Receptor Subunit. Epilepsy Curr. 2002 Jul; 2(4):131-132. PMID: 15309143.
      View in: PubMed
    115. Noebels JL. Human Epilepsy Can Be Linked to a Defective Calcium Channel. Epilepsy Curr. 2002 May; 2(3):95. PMID: 15309155.
      View in: PubMed
    116. Noebels JL. Sodium channel gene expression and epilepsy. Novartis Found Symp. 2002; 241:109-20; discussion 120-3, 226-32. PMID: 11771641.
      View in: PubMed
    117. Noebels JL. Ion Channelopathies and Heritable Epilepsy. News Physiol Sci. 1998 Oct; 13:255-256. PMID: 11390799.
      View in: PubMed
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