IVAN ROSAS

TitleSenior Faculty
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
Address7200 CAMBRIDGE
Houston, TX 77030
vCardDownload vCard

    Collapse ORNG Applications 
    Collapse Verify Publications

    Collapse Biography 
    Collapse education and training
    University of Miami, MiamiInternal Medicine06/1997
    Johns Hopkins Hospital, BaltimorePulmonary and Critical Care Medicine06/2002
    National Heart, Lung and Blood Institute, BethesdaPulmonary Research Fellowship06/2005
    Collapse awards and honors
    2013Fellow American College of Chest Physicians
    2016American Society of Clinical Investigation

    Collapse Overview 
    Collapse overview
    The long-term goal of our pulmonary research program is to better understand mechanisms that contribute to development and progression of parenchymal lung disease thereby enabling us to develop novel diagnostic and therapeutic strategies.

    Robust homeostatic mechanisms preserve human lung health from early age through adult years, however maturity can be associated with the development of parenchymal lung diseases. Our research studies focus on Idiopathic Pulmonary Fibrosis (IPF) and Chronic Obstructive Pulmonary Disease (COPD), disorders commonly observed in aging males with a prior history of tobacco exposure. Our laboratory employs cutting edge genomic technologies and animal models to determine how select molecular derangements contribute to development and progression of parenchymal lung disease associated with established risk factors including smoking, aging, gender and the metabolic syndrome (Morse D, Rosas IO. Tobacco smoke-induced lung fibrosis and emphysema. Annu Rev Physiol. 2014; 76:493-513).

    Our clinical research studies have shown that subclinical pulmonary fibrosis can be detected in at-risk populations including families affected with pulmonary fibrosis, smokers and patients affected with rheumatoid arthritis (Doyle TJ, Hunninghake GM, Rosas IO. Subclinical interstitial lung disease: why you should care. Am J Respir Crit Care Med. 2012 Jun 1; 185(11):1147-53). These studies are transformative as they provide critical evidence that prevention is feasible in common parenchymal lung diseases associated with high morbidity and mortality (Rosas IO, Dellaripa PF, Lederer DJ et al. Interstitial lung disease: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases. Ann Am Thorac Soc. 2014 Apr; 11 Suppl 3:S169-77).

    Collapse Research 
    Collapse research activities and funding
    T32HL007747     (ROSAS, IVAN O.)Jul 1, 1993 - Jun 30, 2021
    NIH/NHLBI
    Research Training in Lung Disease
    Role: Principal Investigator

    K23HL087030     (ROSAS, IVAN O.)Feb 1, 2008 - Jun 30, 2008
    NIH/NHLBI
    Syndecan-2 and Clinical Progression of Idiopathic Pulmonary Fibrosis
    Role: Principal Investigator

    U01HL105371     (CHOI, AUGUSTINE M)Sep 24, 2010 - Jun 30, 2015
    NIH/NHLBI
    Phase II Study of Inhales Carbon Monoxide for the Treatment of Idiopathic Pulmona
    Role: Co-Principal Investigator

    R01HL129920     (ROSAS, IVAN O.)Sep 17, 2015 - Jun 30, 2018
    NIH/NHLBI
    Clinical and Molecular Profiles of Smokers with Subclinical Interstitial Lung Disease
    Role: Principal Investigator

    R01HL130974     (RABY, BENJAMIN ALEXANDER)Jan 1, 2016 - Dec 31, 2019
    NIH/NHLBI
    Clinical Genetics and Screening for Pulmonary Fibrosis
    Role: Co-Principal Investigator

    Genentech IIS     (ROSAS, IVAN ).)Mar 31, 2016 - Apr 1, 2022
    Brigham and Women's Hospital
    Phase II Study of Safety, Tolerability and Efficacy of Pirfenidone in Patients with Rheumatoid Arthritis Interstitial Lung Disease
    Role: Overall Principal Investigator

    U01HL133232     (DUNCAN, STEVEN R)Sep 1, 2017 - Jul 31, 2022
    NIH/NHLBI
    Autoantibody-Targeted Therapy for Acute Exacerbations of Idiopathic Pulmonary Fibrosis
    Role: Co-Principal Investigator

    PR171782     (ROSAS, IVAN O.)Jun 1, 2018 - May 31, 2020
    Department of Defense
    Molecular Profiles of Smokers with Subclinical Interstitial Lung Disease

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Schupp JC, Khanal S, Gomez JL, Sauler M, Adams TS, Chupp GL, Yan X, Poli S, Zhao Y, Montgomery RR, Rosas IO, Dela Cruz CS, Bruscia EM, Egan ME, Kaminski N, Britto CJ. Single-Cell Transcriptional Archetypes of Airway Inflammation in Cystic Fibrosis. Am J Respir Crit Care Med. 2020 11 15; 202(10):1419-1429. PMID: 32603604.
      Citations: 2     Fields:    
    2. Hao Y, Bates S, Mou H, Yun JH, Pham B, Liu J, Qiu W, Guo F, Morrow JD, Hersh CP, Benway CJ, Gong L, Zhang Y, Rosas IO, Cho MH, Park JA, Castaldi PJ, Du F, Zhou X. Genome-Wide Association Study: Functional Variant rs2076295 Regulates Desmoplakin Expression in Airway Epithelial Cells. Am J Respir Crit Care Med. 2020 11 01; 202(9):1225-1236. PMID: 32551799.
      Citations:    Fields:    
    3. Hettiarachchi SU, Li YH, Roy J, Zhang F, Puchulu-Campanella E, Lindeman SD, Srinivasarao M, Tsoyi K, Liang X, Ayaub EA, Nickerson-Nutter C, Rosas IO, Low PS. Targeted inhibition of PI3 kinase/mTOR specifically in fibrotic lung fibroblasts suppresses pulmonary fibrosis in experimental models. Sci Transl Med. 2020 Oct 28; 12(567). PMID: 33115948.
      Citations:    Fields:    
    4. Kim SH, Lee JY, Yoon CM, Shin HJ, Lee SW, Rosas I, Herzog E, Dela Cruz C, Kaminski N, Kang MJ. Mitochondrial antiviral signalling protein is crucial for the development of pulmonary fibrosis. Eur Respir J. 2020 Oct 22. PMID: 33093124.
      Citations:    Fields:    
    5. Bui LT, Winters NI, Chung MI, Joseph C, Gutierrez AJ, Habermann AC, Adams TS, Schupp JC, Poli S, Peter LM, Taylor CJ, Blackburn JB, Richmond BW, Nicholson AG, Rassl D, Wallace WA, Rosas IO, Jenkins RG, Kaminski N, Kropski JA, Banovich NE. Single-cell RNA-sequencing reveals dysregulation of molecular programs associated with SARS-CoV-2 severity and outcomes in patients with chronic lung disease. bioRxiv. 2020 Oct 20. PMID: 33106805.
      Citations:    
    6. Billatos E, Ash SY, Duan F, Xu K, Romanoff J, Marques H, Moses E, Han MK, Regan EA, Bowler RP, Mason SE, Doyle TJ, San José Estépar R, Rosas IO, Ross JC, Xiao X, Liu H, Liu G, Sukumar G, Wilkerson M, Dalgard C, Stevenson C, Whitney D, Aberle D, Spira A, San José Estépar R, Lenburg ME, Washko GR. Distinguishing Smoking-Related Lung Disease Phenotypes Via Imaging and Molecular Features. Chest. 2020 Sep 16. PMID: 32946850.
      Citations:    Fields:    
    7. Shrestha S, Cho W, Stump B, Imani J, Lamattina AM, Louis PH, Pazzanese J, Rosas IO, Visner G, Perrella MA, El-Chemaly S. FK506 induces lung lymphatic endothelial cell senescence and downregulates LYVE-1 expression, with associated decreased hyaluronan uptake. Mol Med. 2020 Jul 31; 26(1):75. PMID: 32736525.
      Citations:    Fields:    
    8. Juge PA, Lee JS, Lau J, Kawano-Dourado L, Rojas Serrano J, Sebastiani M, Koduri G, Matteson E, Bonfiglioli K, Sawamura M, Kairalla R, Cavagna L, Bozzalla Cassione E, Manfredi A, Mejia M, Rodríguez-Henriquez P, González-Pérez MI, Falfán-Valencia R, Buendia-Roldán I, Pérez-Rubio G, Ebstein E, Gazal S, Borie R, Ottaviani S, Kannengiesser C, Wallaert B, Uzunhan Y, Nunes H, Valeyre D, Saidenberg-Kermanac'h N, Boissier MC, Wemeau-Stervinou L, Flipo RM, Marchand-Adam S, Richette P, Allanore Y, Dromer C, Truchetet ME, Richez C, Schaeverbeke T, Lioté H, Thabut G, Deane KD, Solomon J, Doyle T, Ryu JH, Rosas I, Holers VM, Boileau C, Debray MP, Porcher R, Schwartz DA, Vassallo R, Crestani B, Dieudé P. Methotrexate and rheumatoid arthritis associated interstitial lung disease. Eur Respir J. 2020 Jul 09. PMID: 32646919.
      Citations:    Fields:    
    9. Adams TS, Schupp JC, Poli S, Ayaub EA, Neumark N, Ahangari F, Chu SG, Raby BA, DeIuliis G, Januszyk M, Duan Q, Arnett HA, Siddiqui A, Washko GR, Homer R, Yan X, Rosas IO, Kaminski N. Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis. Sci Adv. 2020 Jul; 6(28):eaba1983. PMID: 32832599.
      Citations: 7     Fields:    
    10. Zhang F, Ayaub EA, Wang B, Puchulu-Campanella E, Li YH, Hettiarachchi SU, Lindeman SD, Luo Q, Rout S, Srinivasarao M, Cox A, Tsoyi K, Nickerson-Nutter C, Rosas IO, Low PS. Reprogramming of profibrotic macrophages for treatment of bleomycin-induced pulmonary fibrosis. EMBO Mol Med. 2020 Aug 07; 12(8):e12034. PMID: 32597014.
      Citations:    Fields:    
    11. Courtwright AM, Lamattina AM, Takahashi M, Trindade AJ, Hunninghake GM, Rosas IO, Agarwal S, Raby BA, Goldberg HJ, El-Chemaly S. Shorter telomere length following lung transplantation is associated with clinically significant leukopenia and decreased chronic lung allograft dysfunction-free survival. ERJ Open Res. 2020 Apr; 6(2). PMID: 32577419.
      Citations:    
    12. El-Chemaly S, Taveira-DaSilva A, Bagwe S, Klonowska K, Machado T, Lamattina AM, Goldberg HJ, Jones AM, Julien-Williams P, Maurer R, Rosas IO, Henske EP, Moss J, Kwiatkowski DJ. Celecoxib in lymphangioleiomyomatosis: results of a phase I clinical trial. Eur Respir J. 2020 May; 55(5). PMID: 32060062.
      Citations:    Fields:    
    13. Kawano-Dourado L, Doyle TJ, Bonfiglioli K, Sawamura MVY, Nakagawa RH, Arimura FE, Lee HJ, Rangel DAS, Bueno C, Carvalho CRR, Sabbag ML, Molina C, Rosas IO, Kairalla RA. Baseline Characteristics and Progression of a Spectrum of Interstitial Lung Abnormalities and Disease in Rheumatoid Arthritis. Chest. 2020 Oct; 158(4):1546-1554. PMID: 32428513.
      Citations:    Fields:    
    14. Hunninghake GM, Quesada-Arias LD, Carmichael NE, Martinez Manzano JM, Poli De Frías S, Baumgartner MA, DiGianni L, Gampala-Sagar SN, Leone DA, Gulati S, El-Chemaly S, Goldberg HJ, Putman RK, Hatabu H, Raby BA, Rosas IO. Interstitial Lung Disease in Relatives of Patients with Pulmonary Fibrosis. Am J Respir Crit Care Med. 2020 05 15; 201(10):1240-1248. PMID: 32011908.
      Citations: 1     Fields:    Translation:Humans
    15. Yung LM, Yang P, Joshi S, Augur ZM, Kim SSJ, Bocobo GA, Dinter T, Troncone L, Chen PS, McNeil ME, Southwood M, Poli de Frias S, Knopf J, Rosas IO, Sako D, Pearsall RS, Quisel JD, Li G, Kumar R, Yu PB. ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension. Sci Transl Med. 2020 May 13; 12(543). PMID: 32404506.
      Citations: 2     Fields:    
    16. Tsukui T, Sun KH, Wetter JB, Wilson-Kanamori JR, Hazelwood LA, Henderson NC, Adams TS, Schupp JC, Poli SD, Rosas IO, Kaminski N, Matthay MA, Wolters PJ, Sheppard D. Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis. Nat Commun. 2020 04 21; 11(1):1920. PMID: 32317643.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    17. Hou M, Han J, Li G, Kwon MY, Jiang J, Emani S, Taglauer ES, Park JA, Choi EB, Vodnala M, Fong YW, Emani SM, Rosas IO, Perrella MA, Liu X. Multipotency of mouse trophoblast stem cells. Stem Cell Res Ther. 2020 02 13; 11(1):55. PMID: 32054514.
      Citations:    Fields:    
    18. Kass DJ, Nouraie M, Glassberg MK, Ramreddy N, Fernandez K, Harlow L, Zhang Y, Chen J, Kerr GS, Reimold AM, England BR, Mikuls TR, Gibson KF, Dellaripa PF, Rosas IO, Oddis CV, Ascherman DP. Comparative Profiling of Serum Protein Biomarkers in Rheumatoid Arthritis-Associated Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis. Arthritis Rheumatol. 2020 03; 72(3):409-419. PMID: 31532072.
      Citations: 1     Fields:    Translation:Humans
    19. Chu SG, Poli De Frias S, Sakairi Y, Kelly RS, Chase R, Konishi K, Blau A, Tsai E, Tsoyi K, Padera RF, Sholl LM, Goldberg HJ, Mallidi HR, Camp PC, El-Chemaly SY, Perrella MA, Choi AMK, Washko GR, Raby BA, Rosas IO. Biobanking and cryopreservation of human lung explants for omic analysis. Eur Respir J. 2020 01; 55(1). PMID: 31699836.
      Citations: 1     Fields:    
    20. Chu SG, Poli De Frias S, Raby BA, Rosas IO. An RNA-seq primer for pulmonologists. Eur Respir J. 2020 01; 55(1). PMID: 31601712.
      Citations:    Fields:    
    21. Solomon JJ, Matson S, Kelmenson LB, Chung JH, Hobbs SB, Rosas IO, Dellaripa PF, Doyle TJ, Poli S, Esposito AJ, Visser A, Marin AI, Amigues I, Fernández Pérez ER, Brown KK, Mahler M, Heinz D, Cool C, Deane KD, Swigris JJ, Demoruelle MK. IgA Antibodies Directed Against Citrullinated Protein Antigens Are Elevated in Patients With Idiopathic Pulmonary Fibrosis. Chest. 2020 Jun; 157(6):1513-1521. PMID: 31877269.
      Citations:    Fields:    
    22. Raredon MSB, Adams TS, Suhail Y, Schupp JC, Poli S, Neumark N, Leiby KL, Greaney AM, Yuan Y, Horien C, Linderman G, Engler AJ, Boffa DJ, Kluger Y, Rosas IO, Levchenko A, Kaminski N, Niklason LE. Single-cell connectomic analysis of adult mammalian lungs. Sci Adv. 2019 12; 5(12):eaaw3851. PMID: 31840053.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    23. Hobbs BD, Putman RK, Araki T, Nishino M, Gudmundsson G, Gudnason V, Eiriksdottir G, Zilhao Nogueira NR, Dupuis J, Xu H, O'Connor GT, Manichaikul A, Nguyen J, Podolanczuk AJ, Madahar P, Rotter JI, Lederer DJ, Barr RG, Rich SS, Ampleford EJ, Ortega VE, Peters SP, O'Neal WK, Newell JD, Bleecker ER, Meyers DA, Allen RJ, Oldham JM, Ma SF, Noth I, Jenkins RG, Maher TM, Hubbard RB, Wain LV, Fingerlin TE, Schwartz DA, Washko GR, Rosas IO, Silverman EK, Hatabu H, Cho MH, Hunninghake GM. Overlap of Genetic Risk between Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2019 12 01; 200(11):1402-1413. PMID: 31339356.
      Citations: 5     Fields:    Translation:HumansCells
    24. Chu SG, Villalba JA, Liang X, Xiong K, Tsoyi K, Ith B, Ayaub EA, Tatituri RV, Byers DE, Hsu FF, El-Chemaly S, Kim EY, Shi Y, Rosas IO. Palmitic Acid-Rich High-Fat Diet Exacerbates Experimental Pulmonary Fibrosis by Modulating Endoplasmic Reticulum Stress. Am J Respir Cell Mol Biol. 2019 12; 61(6):737-746. PMID: 31461627.
      Citations: 8     Fields:    Translation:AnimalsCells
    25. Casanova N, Zhou T, Gonzalez-Garay ML, Rosas IO, Goldberg HJ, Ryter SW, Collard HR, El-Chemaly S, Flaherty KR, Hunninghake GM, Lasky JA, Lederer DJ, Machado RF, Martinez FJ, Noth I, Raghu G, Choi AMK, Garcia JGN. Low Dose Carbon Monoxide Exposure in Idiopathic Pulmonary Fibrosis Produces a CO Signature Comprised of Oxidative Phosphorylation Genes. Sci Rep. 2019 10 15; 9(1):14802. PMID: 31615996.
      Citations: 1     Fields:    
    26. Solomon JJ, Danoff SK, Goldberg HJ, Woodhead F, Kolb M, Chambers DC, DiFranco D, Spino C, Haynes-Harp S, Hurwitz S, Peters EB, Dellaripa PF, Rosas IO. The Design and Rationale of the Trail1 Trial: A Randomized Double-Blind Phase 2 Clinical Trial of Pirfenidone in Rheumatoid Arthritis-Associated Interstitial Lung Disease. Adv Ther. 2019 11; 36(11):3279-3287. PMID: 31515704.
      Citations: 4     Fields:    Translation:HumansCTClinical Trials
    27. Sparks JA, He X, Huang J, Fletcher EA, Zaccardelli A, Friedlander HM, Gill RR, Hatabu H, Nishino M, Murphy DJ, Iannaccone CK, Mahmoud TG, Frits ML, Lu B, Rosas IO, Dellaripa PF, Weinblatt ME, Karlson EW, Shadick NA, Doyle TJ. Rheumatoid Arthritis Disease Activity Predicting Incident Clinically Apparent Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Prospective Cohort Study. Arthritis Rheumatol. 2019 09; 71(9):1472-1482. PMID: 30951251.
      Citations: 9     Fields:    Translation:Humans
    28. Putman RK, Gudmundsson G, Axelsson GT, Hida T, Honda O, Araki T, Yanagawa M, Nishino M, Miller ER, Eiriksdottir G, Gudmundsson EF, Tomiyama N, Honda H, Rosas IO, Washko GR, Cho MH, Schwartz DA, Gudnason V, Hatabu H, Hunninghake GM. Imaging Patterns Are Associated with Interstitial Lung Abnormality Progression and Mortality. Am J Respir Crit Care Med. 2019 07 15; 200(2):175-183. PMID: 30673508.
      Citations: 5     Fields:    Translation:Humans
    29. Tang Y, El-Chemaly S, Taveira-Dasilva A, Goldberg HJ, Bagwe S, Rosas IO, Moss J, Priolo C, Henske EP. Alterations in Polyamine Metabolism in Patients With Lymphangioleiomyomatosis and Tuberous Sclerosis Complex 2-Deficient Cells. Chest. 2019 12; 156(6):1137-1148. PMID: 31299246.
      Citations: 3     Fields:    Translation:HumansCellsCTClinical Trials
    30. Harmouche R, Ash SY, Putman RK, Hunninghake GM, San Jose Estepar R, Martinez FJ, Choi AM, Lynch DA, Hatabu H, Han MK, Bowler RP, Kalhan R, Rosas IO, Washko GR, San Jose Estepar R. Objectively Measured Chronic Lung Injury on Chest CT. Chest. 2019 12; 156(6):1149-1159. PMID: 31233744.
      Citations:    Fields:    Translation:Humans
    31. Courtwright AM, Lamattina AM, Louis PH, Trindade AJ, Burkett P, Imani J, Shrestha S, Divo M, Keller S, Rosas IO, Goldberg HJ, El-Chemaly S. Hyaluronan and LYVE-1 and allograft function in lung transplantation recipients. Sci Rep. 2019 06 21; 9(1):9003. PMID: 31227795.
      Citations: 1     Fields:    Translation:Humans
    32. Tsoyi K, Osorio JC, Chu SG, Fernandez IE, De Frias SP, Sholl L, Cui Y, Tellez CS, Siegfried JM, Belinsky SA, Perrella MA, El-Chemaly S, Rosas IO. Lung Adenocarcinoma Syndecan-2 Potentiates Cell Invasiveness. Am J Respir Cell Mol Biol. 2019 06; 60(6):659-666. PMID: 30562054.
      Citations:    Fields:    Translation:HumansAnimalsCells
    33. Lee CM, He CH, Park JW, Lee JH, Kamle S, Ma B, Akosman B, Cotez R, Chen E, Zhou Y, Herzog EL, Ryu C, Peng X, Rosas IO, Poli S, Bostwick CF, Choi AM, Elias JA, Lee CG. Chitinase 1 regulates pulmonary fibrosis by modulating TGF-ß/SMAD7 pathway via TGFBRAP1 and FOXO3. Life Sci Alliance. 2019 06; 2(3). PMID: 31085559.
      Citations: 1     Fields:    Translation:HumansCells
    34. Stump B, Shrestha S, Lamattina AM, Louis PH, Cho W, Perrella MA, Ai X, Rosas IO, Wagner FF, Priolo C, Astin J, El-Chemaly S. Glycogen synthase kinase 3-ß inhibition induces lymphangiogenesis through ß-catenin-dependent and mTOR-independent pathways. PLoS One. 2019; 14(4):e0213831. PMID: 30964887.
      Citations: 1     Fields:    Translation:HumansCells
    35. Miller ER, Putman RK, Diaz AA, Xu H, San José Estépar R, Araki T, Nishino M, Poli de Frías S, Hida T, Ross J, Coxson H, Dupuis J, O'Connor GT, Silverman EK, Rosas IO, Hatabu H, Washko G, Hunninghake GM. Increased Airway Wall Thickness in Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis. Ann Am Thorac Soc. 2019 04; 16(4):447-454. PMID: 30543456.
      Citations: 4     Fields:    Translation:Humans
    36. Lamattina AM, Poli S, Kidambi P, Bagwe S, Courtwright A, Louis PH, Shrestha S, Stump B, Goldberg HJ, Thiele EA, Rosas I, Henske EP, El-Chemaly S. Serum endostatin levels are associated with diffusion capacity and with tuberous sclerosis- associated lymphangioleiomyomatosis. Orphanet J Rare Dis. 2019 03 29; 14(1):72. PMID: 30922357.
      Citations:    Fields:    Translation:Humans
    37. Sparks JA, Doyle TJ, He X, Pan B, Iannaccone C, Frits ML, Dellaripa PF, Rosas IO, Lu B, Weinblatt ME, Shadick NA, Karlson EW. Incidence and predictors of dyspnea on exertion in a prospective cohort of patients with rheumatoid arthritis. ACR Open Rheumatol. 2019 Mar; 1(1):4-15. PMID: 30923795.
      Citations:    
    38. Ryter SW, Rosas IO, Owen CA, Martinez FJ, Choi ME, Lee CG, Elias JA, Choi AMK. Mitochondrial Dysfunction as a Pathogenic Mediator of Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis. Ann Am Thorac Soc. 2018 12; 15(Suppl 4):S266-S272. PMID: 30759019.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    39. Juge PA, Lee JS, Ebstein E, Furukawa H, Dobrinskikh E, Gazal S, Kannengiesser C, Ottaviani S, Oka S, Tohma S, Tsuchiya N, Rojas-Serrano J, González-Pérez MI, Mejía M, Buendía-Roldán I, Falfán-Valencia R, Ambrocio-Ortiz E, Manali E, Papiris SA, Karageorgas T, Boumpas D, Antoniou K, van Moorsel CHM, van der Vis J, de Man YA, Grutters JC, Wang Y, Borie R, Wemeau-Stervinou L, Wallaert B, Flipo RM, Nunes H, Valeyre D, Saidenberg-Kermanac'h N, Boissier MC, Marchand-Adam S, Frazier A, Richette P, Allanore Y, Sibilia J, Dromer C, Richez C, Schaeverbeke T, Lioté H, Thabut G, Nathan N, Amselem S, Soubrier M, Cottin V, Clément A, Deane K, Walts AD, Fingerlin T, Fischer A, Ryu JH, Matteson EL, Niewold TB, Assayag D, Gross A, Wolters P, Schwarz MI, Holers M, Solomon JJ, Doyle T, Rosas IO, Blauwendraat C, Nalls MA, Debray MP, Boileau C, Crestani B, Schwartz DA, Dieudé P. MUC5B Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease. N Engl J Med. 2018 12 06; 379(23):2209-2219. PMID: 30345907.
      Citations: 27     Fields:    Translation:HumansCells
    40. Lee CM, Cho SJ, Cho WK, Park JW, Lee JH, Choi AM, Rosas IO, Zheng M, Peltz G, Lee CG, Elias JA. Laminin a1 is a genetic modifier of TGF-ß1-stimulated pulmonary fibrosis. JCI Insight. 2018 09 20; 3(18). PMID: 30232270.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    41. Lamattina AM, Taveira-Dasilva A, Goldberg HJ, Bagwe S, Cui Y, Rosas IO, Moss J, Henske EP, El-Chemaly S. Circulating Biomarkers From the Phase 1 Trial of Sirolimus and Autophagy Inhibition for Patients With Lymphangioleiomyomatosis. Chest. 2018 11; 154(5):1070-1082. PMID: 30144422.
      Citations: 4     Fields:    Translation:HumansCTClinical Trials
    42. Romero F, Hong X, Shah D, Kallen CB, Rosas I, Guo Z, Schriner D, Barta J, Shaghaghi H, Hoek JB, Mesaros C, Choi AM, Snyder NW, Summer R. Lipid Synthesis Is Required to Resolve Endoplasmic Reticulum Stress and Limit Fibrotic Responses in the Lung. Am J Respir Cell Mol Biol. 2018 08; 59(2):225-236. PMID: 29465261.
      Citations: 7     Fields:    Translation:HumansAnimals
    43. Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BA. NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension. Sci Transl Med. 2018 06 13; 10(445). PMID: 29899023.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    44. Ash SY, Harmouche R, Ross JC, Diaz AA, Rahaghi FN, Vegas Sanchez-Ferrero G, Putman RK, Hunninghake GM, Onieva Onieva J, Martinez FJ, Choi AM, Bowler RP, Lynch DA, Hatabu H, Bhatt SP, Dransfield MT, Wells JM, Rosas IO, San Jose Estepar R, Washko GR. Interstitial Features at Chest CT Enhance the Deleterious Effects of Emphysema in the COPDGene Cohort. Radiology. 2018 08; 288(2):600-609. PMID: 29869957.
      Citations: 3     Fields:    Translation:Humans
    45. Courtwright AM, Baldi BG, Kidambi P, Cui Y, Lamattina AM, Villalba JA, Bagwe S, Goldberg HJ, Rosas IO, Henske EP, Carvalho CRR, El-Chemaly S. Characterization of lymphangioleiomyomatosis patients with discordance between spirometric and diffusion measurements of pulmonary function. Sarcoidosis Vasc Diffuse Lung Dis. 2018; 35(3):206-212. PMID: 32476904.
      Citations:    Fields:    
    46. Doyle TJ, Dhillon N, Madan R, Cabral F, Fletcher EA, Koontz DC, Aggarwal R, Osorio JC, Rosas IO, Oddis CV, Dellaripa PF. Rituximab in the Treatment of Interstitial Lung Disease Associated with Antisynthetase Syndrome: A Multicenter Retrospective Case Review. J Rheumatol. 2018 06; 45(6):841-850. PMID: 29606668.
      Citations: 5     Fields:    Translation:Humans
    47. Miller ER, Putman RK, Vivero M, Hung Y, Araki T, Nishino M, Washko GR, Rosas IO, Hatabu H, Sholl LM, Hunninghake GM. Histopathology of Interstitial Lung Abnormalities in the Context of Lung Nodule Resections. Am J Respir Crit Care Med. 2018 04 01; 197(7):955-958. PMID: 28934558.
      Citations: 5     Fields:    Translation:Humans
    48. El-Chemaly S, O'Brien KJ, Nathan SD, Weinhouse GL, Goldberg HJ, Connors JM, Cui Y, Astor TL, Camp PC, Rosas IO, Lemma M, Speransky V, Merideth MA, Gahl WA, Gochuico BR. Clinical management and outcomes of patients with Hermansky-Pudlak syndrome pulmonary fibrosis evaluated for lung transplantation. PLoS One. 2018; 13(3):e0194193. PMID: 29547626.
      Citations: 4     Fields:    Translation:HumansCTClinical Trials
    49. Ash SY, Harmouche R, Putman RK, Ross JC, Martinez FJ, Choi AM, Bowler RP, Regan EA, Curtis JL, Han MK, Boucher RC, O'Neal WK, Hatabu H, Lynch DA, Rosas IO, Hunninghake GM, San Jose Estepar R, Washko GR. Association between acute respiratory disease events and the MUC5B promoter polymorphism in smokers. Thorax. 2018 11; 73(11):1071-1074. PMID: 29440587.
      Citations: 1     Fields:    Translation:HumansCells
    50. Ghanta S, Kwon MY, Rosas IO, Liu X, Perrella MA. Mesenchymal Stromal Cell Therapy: Does the Source Matter? Crit Care Med. 2018 02; 46(2):343-345. PMID: 29337802.
      Citations:    Fields:    Translation:HumansCells
    51. Tsoyi K, Chu SG, Patino-Jaramillo NG, Wilder J, Villalba J, Doyle-Eisele M, McDonald J, Liu X, El-Chemaly S, Perrella MA, Rosas IO. Syndecan-2 Attenuates Radiation-induced Pulmonary Fibrosis and Inhibits Fibroblast Activation by Regulating PI3K/Akt/ROCK Pathway via CD148. Am J Respir Cell Mol Biol. 2018 02; 58(2):208-215. PMID: 28886261.
      Citations: 12     Fields:    Translation:AnimalsCellsPHPublic Health
    52. Courtwright AM, Burkett P, Divo M, Keller S, Rosas IO, Trindade A, Mody GN, Singh SK, El-Chemaly S, Camp PC, Goldberg HJ, Mallidi HR. Posttransplant Lymphoproliferative Disorders in Epstein-Barr Virus Donor Positive/Recipient Negative Lung Transplant Recipients. Ann Thorac Surg. 2018 Feb; 105(2):441-447. PMID: 29223419.
      Citations:    Fields:    Translation:HumansCells
    53. Rosas IO, Goldberg HJ, Collard HR, El-Chemaly S, Flaherty K, Hunninghake GM, Lasky JA, Lederer DJ, Machado R, Martinez FJ, Maurer R, Teller D, Noth I, Peters E, Raghu G, Garcia JGN, Choi AMK. A Phase II Clinical Trial of Low-Dose Inhaled Carbon Monoxide in Idiopathic Pulmonary Fibrosis. Chest. 2018 01; 153(1):94-104. PMID: 29100885.
      Citations: 9     Fields:    Translation:HumansCTClinical Trials
    54. Diaz AA, Strand M, Coxson HO, Ross JC, San Jose Estepar R, Lynch D, van Rikxoort EM, Rosas IO, Hunninghake GM, Putman RK, Hatabu H, Yen A, Kinney GL, Hokanson JE, Silverman EK, Crapo J, Washko GR. Disease Severity Dependence of the Longitudinal Association Between CT Lung Density and Lung Function in Smokers. Chest. 2018 03; 153(3):638-645. PMID: 29066389.
      Citations: 4     Fields:    Translation:Humans
    55. Herazo-Maya JD, Sun J, Molyneaux PL, Li Q, Villalba JA, Tzouvelekis A, Lynn H, Juan-Guardela BM, Risquez C, Osorio JC, Yan X, Michel G, Aurelien N, Lindell KO, Klesen MJ, Moffatt MF, Cookson WO, Zhang Y, Garcia JGN, Noth I, Prasse A, Bar-Joseph Z, Gibson KF, Zhao H, Herzog EL, Rosas IO, Maher TM, Kaminski N. Validation of a 52-gene risk profile for outcome prediction in patients with idiopathic pulmonary fibrosis: an international, multicentre, cohort study. Lancet Respir Med. 2017 11; 5(11):857-868. PMID: 28942086.
      Citations: 16     Fields:    Translation:HumansCells
    56. Putman RK, Gudmundsson G, Araki T, Nishino M, Sigurdsson S, Gudmundsson EF, Eiríksdottír G, Aspelund T, Ross JC, San José Estépar R, Miller ER, Yamada Y, Yanagawa M, Tomiyama N, Launer LJ, Harris TB, El-Chemaly S, Raby BA, Cho MH, Rosas IO, Washko GR, Schwartz DA, Silverman EK, Gudnason V, Hatabu H, Hunninghake GM. The MUC5B promoter polymorphism is associated with specific interstitial lung abnormality subtypes. Eur Respir J. 2017 09; 50(3). PMID: 28893869.
      Citations: 9     Fields:    Translation:HumansCells
    57. Diaz AA, Rahaghi FN, Doyle TJ, Young TP, Maclean ES, Martinez CH, San José Estépar R, Guerra S, Tesfaigzi Y, Rosas IO, Washko GR, Wilson DO. Differences in Respiratory Symptoms and Lung Structure Between Hispanic and Non-Hispanic White Smokers: A Comparative Study. Chronic Obstr Pulm Dis. 2017 Sep 05; 4(4):297-304. PMID: 29354674.
      Citations:    
    58. Zazueta OE, Preston SE, Moniodis A, Fried S, Kim M, Townsend K, Wood I, Boukedes S, Guleria I, Camp P, El-Chemaly S, Rosas IO, Chandraker A, Milford E, Goldberg HJ. The Presence of Pretransplant HLA Antibodies Does Not Impact the Development of Chronic Lung Allograft Dysfunction or CLAD-Related Death. Transplantation. 2017 09; 101(9):2207-2212. PMID: 27893614.
      Citations: 6     Fields:    Translation:Humans
    59. Kristof AS, Petrof BJ, Hamid Q, Kolb M, Landry JS, MacKenzie A, McCormack FX, Murawski IJ, Moss J, Rauch F, Rosas IO, Shapiro AJ, Smith BM, Thomas DY, Trapnell BC, Young LR, Zariwala MA. An Official American Thoracic Society Workshop Report: Translational Research in Rare Respiratory Diseases. Ann Am Thorac Soc. 2017 Aug; 14(8):1239-1247. PMID: 28763267.
      Citations:    Fields:    Translation:HumansAnimals
    60. Ash SY, Harmouche R, Putman RK, Ross JC, Diaz AA, Hunninghake GM, Onieva Onieva J, Martinez FJ, Choi AM, Lynch DA, Hatabu H, Rosas IO, San Jose Estepar R, Washko GR. Clinical and Genetic Associations of Objectively Identified Interstitial Changes in Smokers. Chest. 2017 10; 152(4):780-791. PMID: 28506611.
      Citations: 8     Fields:    Translation:HumansCells
    61. Gazourian L, Ash S, Meserve EEK, Diaz A, Estepar RSJ, El-Chemaly SY, Rosas IO, Divo M, Fuhlbrigge AL, Camp PC, Ho VT, Bhatt AS, Goldberg HJ, Sholl LM, Washko GR. Quantitative computed tomography assessment of bronchiolitis obliterans syndrome after lung transplantation. Clin Transplant. 2017 05; 31(5). PMID: 28244139.
      Citations:    Fields:    Translation:Humans
    62. Moniodis A, Townsend K, Rabin A, Aloum O, Stempel J, Burkett P, Camp P, Divo M, El-Chemaly S, Mallidi H, Rosas I, Fuhlbrigge A, Koo S, Goldberg HJ. Comparison of extracorporeal photopheresis and alemtuzumab for the treatment of chronic lung allograft dysfunction. J Heart Lung Transplant. 2018 03; 37(3):340-348. PMID: 28431983.
      Citations: 3     Fields:    Translation:Humans
    63. Ash SY, Harmouche R, Vallejo DL, Villalba JA, Ostridge K, Gunville R, Come CE, Onieva Onieva J, Ross JC, Hunninghake GM, El-Chemaly SY, Doyle TJ, Nardelli P, Sanchez-Ferrero GV, Goldberg HJ, Rosas IO, San Jose Estepar R, Washko GR. Densitometric and local histogram based analysis of computed tomography images in patients with idiopathic pulmonary fibrosis. Respir Res. 2017 03 07; 18(1):45. PMID: 28264721.
      Citations: 15     Fields:    Translation:Humans
    64. Cui Y, Steagall WK, Lamattina AM, Pacheco-Rodriguez G, Stylianou M, Kidambi P, Stump B, Golzarri F, Rosas IO, Priolo C, Henske EP, Moss J, El-Chemaly S. Aberrant SYK Kinase Signaling Is Essential for Tumorigenesis Induced by TSC2 Inactivation. Cancer Res. 2017 03 15; 77(6):1492-1502. PMID: 28202529.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    65. El-Chemaly S, Taveira-Dasilva A, Goldberg HJ, Peters E, Haughey M, Bienfang D, Jones AM, Julien-Williams P, Cui Y, Villalba JA, Bagwe S, Maurer R, Rosas IO, Moss J, Henske EP. Sirolimus and Autophagy Inhibition in Lymphangioleiomyomatosis: Results of a Phase I Clinical Trial. Chest. 2017 06; 151(6):1302-1310. PMID: 28192114.
      Citations: 11     Fields:    Translation:HumansCTClinical Trials
    66. Araki T, Putman RK, Hatabu H, Gao W, Dupuis J, Latourelle JC, Nishino M, Zazueta OE, Kurugol S, Ross JC, San José Estépar R, Schwartz DA, Rosas IO, Washko GR, O'Connor GT, Hunninghake GM. Development and Progression of Interstitial Lung Abnormalities in the Framingham Heart Study. Am J Respir Crit Care Med. 2016 12 15; 194(12):1514-1522. PMID: 27314401.
      Citations: 37     Fields:    Translation:Humans
    67. Ash SY, Harmouche R, Ross JC, Diaz AA, Hunninghake GM, Putman RK, Onieva J, Martinez FJ, Choi AM, Lynch DA, Hatabu H, Rosas IO, Estepar RSJ, Washko GR. The Objective Identification and Quantification of Interstitial Lung Abnormalities in Smokers. Acad Radiol. 2017 08; 24(8):941-946. PMID: 27989445.
      Citations: 9     Fields:    Translation:Humans
    68. White ES, Xia M, Murray S, Dyal R, Flaherty CM, Flaherty KR, Moore BB, Cheng L, Doyle TJ, Villalba J, Dellaripa PF, Rosas IO, Kurtis JD, Martinez FJ. Plasma Surfactant Protein-D, Matrix Metalloproteinase-7, and Osteopontin Index Distinguishes Idiopathic Pulmonary Fibrosis from Other Idiopathic Interstitial Pneumonias. Am J Respir Crit Care Med. 2016 11 15; 194(10):1242-1251. PMID: 27149370.
      Citations: 29     Fields:    Translation:Humans
    69. Rosas IO. Imaging and molecular biomarkers: a novel approach to screen populations at risk of pulmonary fibrosis? Eur Respir J. 2016 11; 48(5):1271-1273. PMID: 27799380.
      Citations:    Fields:    Translation:Humans
    70. Courtwright AM, Fried S, Villalba JA, Moniodis A, Guleria I, Wood I, Milford E, Mallidi HH, Hunninghake GM, Raby BA, Agarwal S, Camp PC, Rosas IO, Goldberg HJ, El-Chemaly S. Association of Donor and Recipient Telomere Length with Clinical Outcomes following Lung Transplantation. PLoS One. 2016; 11(9):e0162409. PMID: 27589328.
      Citations: 4     Fields:    Translation:HumansCells
    71. Stout-Delgado HW, Cho SJ, Chu SG, Mitzel DN, Villalba J, El-Chemaly S, Ryter SW, Choi AM, Rosas IO. Age-Dependent Susceptibility to Pulmonary Fibrosis Is Associated with NLRP3 Inflammasome Activation. Am J Respir Cell Mol Biol. 2016 08; 55(2):252-63. PMID: 26933834.
      Citations: 25     Fields:    Translation:AnimalsCells
    72. Travers TS, Harlow L, Rosas IO, Gochuico BR, Mikuls TR, Bhattacharya SK, Camacho CJ, Ascherman DP. Extensive Citrullination Promotes Immunogenicity of HSP90 through Protein Unfolding and Exposure of Cryptic Epitopes. J Immunol. 2016 09 01; 197(5):1926-36. PMID: 27448590.
      Citations: 6     Fields:    Translation:HumansCells
    73. Courtwright AM, Salomon S, Fuhlbrigge A, Divo M, Rosas IO, Camp PC, Mallidi HH, Burkett P, El-Chemaly S, Wolfe DJ, Goldberg HJ. Predictors and outcomes of unplanned early rehospitalization in the first year following lung transplantation. Clin Transplant. 2016 09; 30(9):1053-8. PMID: 27312895.
      Citations: 3     Fields:    Translation:Humans
    74. Ho JE, Gao W, Levy D, Santhanakrishnan R, Araki T, Rosas IO, Hatabu H, Latourelle JC, Nishino M, Dupuis J, Washko GR, O'Connor GT, Hunninghake GM. Galectin-3 Is Associated with Restrictive Lung Disease and Interstitial Lung Abnormalities. Am J Respir Crit Care Med. 2016 07 01; 194(1):77-83. PMID: 26771117.
      Citations: 11     Fields:    Translation:Humans
    75. Kammerl IE, Dann A, Mossina A, Brech D, Lukas C, Vosyka O, Nathan P, Conlon TM, Wagner DE, Overkleeft HS, Prasse A, Rosas IO, Straub T, Krauss-Etschmann S, Königshoff M, Preissler G, Winter H, Lindner M, Hatz R, Behr J, Heinzelmann K, Yildirim AÖ, Noessner E, Eickelberg O, Meiners S. Impairment of Immunoproteasome Function by Cigarette Smoke and in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2016 06 01; 193(11):1230-41. PMID: 26756824.
      Citations: 5     Fields:    Translation:HumansAnimals
    76. Chu SG, El-Chemaly S, Rosas IO. Genetics and Idiopathic Interstitial Pneumonias. Semin Respir Crit Care Med. 2016 06; 37(3):321-30. PMID: 27231858.
      Citations: 1     Fields:    Translation:Humans
    77. Bai Y, Krishnamoorthy N, Patel KR, Rosas I, Sanderson MJ, Ai X. Cryopreserved Human Precision-Cut Lung Slices as a Bioassay for Live Tissue Banking. A Viability Study of Bronchodilation with Bitter-Taste Receptor Agonists. Am J Respir Cell Mol Biol. 2016 05; 54(5):656-63. PMID: 26550921.
      Citations: 11     Fields:    Translation:HumansCells
    78. Putman RK, Hatabu H, Araki T, Gudmundsson G, Gao W, Nishino M, Okajima Y, Dupuis J, Latourelle JC, Cho MH, El-Chemaly S, Coxson HO, Celli BR, Fernandez IE, Zazueta OE, Ross JC, Harmouche R, Estépar RS, Diaz AA, Sigurdsson S, Gudmundsson EF, Eiríksdottír G, Aspelund T, Budoff MJ, Kinney GL, Hokanson JE, Williams MC, Murchison JT, MacNee W, Hoffmann U, O'Donnell CJ, Launer LJ, Harrris TB, Gudnason V, Silverman EK, O'Connor GT, Washko GR, Rosas IO, Hunninghake GM. Association Between Interstitial Lung Abnormalities and All-Cause Mortality. JAMA. 2016 Feb 16; 315(7):672-81. PMID: 26881370.
      Citations: 64     Fields:    Translation:Humans
    79. Wells AU, Rosas IO. Broad Therapeutic Efficacy of Nintedanib in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2016 Jan 15; 193(2):112-3. PMID: 26771414.
      Citations: 2     Fields:    Translation:Humans
    80. Bertero T, Cottrill KA, Annis S, Bhat B, Gochuico BR, Osorio JC, Rosas I, Haley KJ, Corey KE, Chung RT, Nelson Chau B, Chan SY. A YAP/TAZ-miR-130/301 molecular circuit exerts systems-level control of fibrosis in a network of human diseases and physiologic conditions. Sci Rep. 2015 Dec 15; 5:18277. PMID: 26667495.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    81. Kliment CR, Araki T, Doyle TJ, Gao W, Dupuis J, Latourelle JC, Zazueta OE, Fernandez IE, Nishino M, Okajima Y, Ross JC, Estépar RS, Diaz AA, Lederer DJ, Schwartz DA, Silverman EK, Rosas IO, Washko GR, O'Connor GT, Hatabu H, Hunninghake GM. A comparison of visual and quantitative methods to identify interstitial lung abnormalities. BMC Pulm Med. 2015 Oct 29; 15:134. PMID: 26514822.
      Citations: 11     Fields:    Translation:HumansCells
    82. Cui Y, Liu K, Monzon-Medina ME, Padera RF, Wang H, George G, Toprak D, Abdelnour E, D'Agostino E, Goldberg HJ, Perrella MA, Forteza RM, Rosas IO, Visner G, El-Chemaly S. Therapeutic lymphangiogenesis ameliorates established acute lung allograft rejection. J Clin Invest. 2015 Nov 02; 125(11):4255-68. PMID: 26485284.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    83. Jacob S, Courtwright A, El-Chemaly S, Racila E, Divo M, Burkett P, Fuhlbrigge A, Goldberg HJ, Rosas IO, Camp P. Donor-acquired fat embolism syndrome after lung transplantation. Eur J Cardiothorac Surg. 2016 May; 49(5):1344-7. PMID: 26468269.
      Citations: 1     Fields:    Translation:Humans
    84. Sheikh AQ, Misra A, Rosas IO, Adams RH, Greif DM. Smooth muscle cell progenitors are primed to muscularize in pulmonary hypertension. Sci Transl Med. 2015 Oct 07; 7(308):308ra159. PMID: 26446956.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    85. Polverino F, Cosio BG, Pons J, Laucho-Contreras M, Tejera P, Iglesias A, Rios A, Jahn A, Sauleda J, Divo M, Pinto-Plata V, Sholl L, Rosas IO, Agustí A, Celli BR, Owen CA. B Cell-Activating Factor. An Orchestrator of Lymphoid Follicles in Severe Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2015 Sep 15; 192(6):695-705. PMID: 26073875.
      Citations: 31     Fields:    Translation:HumansCells
    86. Paulin F, Doyle TJ, Fletcher EA, Ascherman DP, Rosas IO. Rheumatoid Arthritis-Associated Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis: Shared Mechanistic and Phenotypic Traits Suggest Overlapping Disease Mechanisms. Rev Invest Clin. 2015 Sep-Oct; 67(5):280-6. PMID: 26696331.
      Citations: 7     Fields:    Translation:Humans
    87. Goldberg HJ, Harari S, Cottin V, Rosas IO, Peters E, Biswal S, Cheng Y, Khindri S, Kovarik JM, Ma S, McCormack FX, Henske EP. Everolimus for the treatment of lymphangioleiomyomatosis: a phase II study. Eur Respir J. 2015 Sep; 46(3):783-94. PMID: 26113676.
      Citations: 19     Fields:    Translation:HumansCTClinical Trials
    88. Doyle TJ, Patel AS, Hatabu H, Nishino M, Wu G, Osorio JC, Golzarri MF, Traslosheros A, Chu SG, Frits ML, Iannaccone CK, Koontz D, Fuhrman C, Weinblatt ME, El-Chemaly SY, Washko GR, Hunninghake GM, Choi AM, Dellaripa PF, Oddis CV, Shadick NA, Ascherman DP, Rosas IO. Detection of Rheumatoid Arthritis-Interstitial Lung Disease Is Enhanced by Serum Biomarkers. Am J Respir Crit Care Med. 2015 Jun 15; 191(12):1403-12. PMID: 25822095.
      Citations: 27     Fields:    Translation:Humans
    89. George G, Rosas IO, Cui Y, McKane C, Hunninghake GM, Camp PC, Raby BA, Goldberg HJ, El-Chemaly S. Short telomeres, telomeropathy, and subclinical extrapulmonary organ damage in patients with interstitial lung disease. Chest. 2015 Jun; 147(6):1549-1557. PMID: 25393420.
      Citations: 15     Fields:    Translation:HumansCells
    90. White K, Lu Y, Annis S, Hale AE, Chau BN, Dahlman JE, Hemann C, Opotowsky AR, Vargas SO, Rosas I, Perrella MA, Osorio JC, Haley KJ, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Khan OF, Bader A, Gochuico BR, Matar M, Polach K, Johannessen NM, Prosser HM, Anderson DG, Langer R, Zweier JL, Bindoff LA, Systrom D, Waxman AB, Jin RC, Chan SY. Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension. EMBO Mol Med. 2015 Jun; 7(6):695-713. PMID: 25825391.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    91. Araki T, Nishino M, Zazueta OE, Gao W, Dupuis J, Okajima Y, Latourelle JC, Rosas IO, Murakami T, O'Connor GT, Washko GR, Hunninghake GM, Hatabu H. Paraseptal emphysema: Prevalence and distribution on CT and association with interstitial lung abnormalities. Eur J Radiol. 2015 Jul; 84(7):1413-8. PMID: 25868675.
      Citations: 18     Fields:    Translation:Humans
    92. Patel AS, Song JW, Chu SG, Mizumura K, Osorio JC, Shi Y, El-Chemaly S, Lee CG, Rosas IO, Elias JA, Choi AM, Morse D. Epithelial cell mitochondrial dysfunction and PINK1 are induced by transforming growth factor-beta1 in pulmonary fibrosis. PLoS One. 2015; 10(3):e0121246. PMID: 25785991.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    93. Rosas IO, Kaminski N. Update in diffuse parenchymal lung disease, 2013. Am J Respir Crit Care Med. 2015 Feb 01; 191(3):270-4. PMID: 25635490.
      Citations: 1     Fields:    Translation:Humans
    94. Grewal AS, Padera RF, Boukedes S, Divo M, Rosas IO, Camp PC, Fuhlbrigge A, Goldberg H, El-Chemaly S. Prevalence and outcome of lung cancer in lung transplant recipients. Respir Med. 2015 Mar; 109(3):427-33. PMID: 25616348.
      Citations: 6     Fields:    Translation:Humans
    95. Chen J, Doyle TJ, Liu Y, Aggarwal R, Wang X, Shi Y, Ge SX, Huang H, Lin Q, Liu W, Cai Y, Koontz D, Fuhrman CR, Golzarri MF, Liu Y, Hatabu H, Nishino M, Araki T, Dellaripa PF, Oddis CV, Rosas IO, Ascherman DP. Biomarkers of rheumatoid arthritis-associated interstitial lung disease. Arthritis Rheumatol. 2015 Jan; 67(1):28-38. PMID: 25302945.
      Citations: 22     Fields:    Translation:Humans
    96. Liu F, Lagares D, Choi KM, Stopfer L, Marinkovic A, Vrbanac V, Probst CK, Hiemer SE, Sisson TH, Horowitz JC, Rosas IO, Fredenburgh LE, Feghali-Bostwick C, Varelas X, Tager AM, Tschumperlin DJ. Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis. . 2015 Feb 15; 308(4):L344-57. PMID: 25502501.
      Citations:    
    97. Cui Y, Wilder J, Rietz C, Gigliotti A, Tang X, Shi Y, Guilmette R, Wang H, George G, Nilo de Magaldi E, Chu SG, Doyle-Eisele M, McDonald JD, Rosas IO, El-Chemaly S. Radiation-induced impairment in lung lymphatic vasculature. Lymphat Res Biol. 2014 Dec; 12(4):238-50. PMID: 25412238.
      Citations: 8     Fields:    Translation:AnimalsPHPublic Health
    98. Li C, Zhang E, Sun Y, Lee PS, Zhan Y, Guo Y, Osorio JC, Rosas IO, Xu KF, Kwiatkowski DJ, Yu JJ. Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis and lymphangioleiomyomatosis. PLoS One. 2014; 9(10):e104809. PMID: 25347447.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    99. Harlow L, Gochuico BR, Rosas IO, Doyle TJ, Osorio JC, Travers TS, Camacho CC, Oddis CV, Ascherman DP. Anti-citrullinated heat shock protein 90 antibodies identified in bronchoalveolar lavage fluid are a marker of lung-specific immune responses. Clin Immunol. 2014 Nov; 155(1):60-70. PMID: 25150019.
      Citations: 8     Fields:    Translation:Humans
    100. Doyle TJ, Dellaripa PF, Batra K, Frits ML, Iannaccone CK, Hatabu H, Nishino M, Weinblatt ME, Ascherman DP, Washko GR, Hunninghake GM, Choi AMK, Shadick NA, Rosas IO. Functional impact of a spectrum of interstitial lung abnormalities in rheumatoid arthritis. Chest. 2014 Jul; 146(1):41-50. PMID: 24305643.
      Citations: 24     Fields:    Translation:Humans
    101. Moon HG, Kim SH, Gao J, Quan T, Qin Z, Osorio JC, Rosas IO, Wu M, Tesfaigzi Y, Jin Y. CCN1 secretion and cleavage regulate the lung epithelial cell functions after cigarette smoke. . 2014 Aug 15; 307(4):L326-37. PMID: 24973403.
      Citations:    
    102. Craig VJ, Polverino F, Laucho-Contreras ME, Shi Y, Liu Y, Osorio JC, Tesfaigzi Y, Pinto-Plata V, Gochuico BR, Rosas IO, Owen CA. Mononuclear phagocytes and airway epithelial cells: novel sources of matrix metalloproteinase-8 (MMP-8) in patients with idiopathic pulmonary fibrosis. PLoS One. 2014; 9(5):e97485. PMID: 24828408.
      Citations: 14     Fields:    Translation:HumansCells
    103. Putman RK, Rosas IO, Hunninghake GM. Genetics and early detection in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2014 Apr 01; 189(7):770-8. PMID: 24547893.
      Citations: 25     Fields:    Translation:Humans
    104. Rosas IO, Dellaripa PF, Lederer DJ, Khanna D, Young LR, Martinez FJ. Interstitial lung disease: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases. Ann Am Thorac Soc. 2014 Apr; 11 Suppl 3:S169-77. PMID: 24754826.
      Citations: 13     Fields:    Translation:HumansPHPublic Health
    105. Cui Y, Osorio JC, Risquez C, Wang H, Shi Y, Gochuico BR, Morse D, Rosas IO, El-Chemaly S. Transforming growth factor-ß1 downregulates vascular endothelial growth factor-D expression in human lung fibroblasts via the Jun NH2-terminal kinase signaling pathway. Mol Med. 2014 Mar 20; 20:120-34. PMID: 24515257.
      Citations: 9     Fields:    Translation:HumansCells
    106. Doyle TJ, Lee JS, Dellaripa PF, Lederer JA, Matteson EL, Fischer A, Ascherman DP, Glassberg MK, Ryu JH, Danoff SK, Brown KK, Collard HR, Rosas IO. A roadmap to promote clinical and translational research in rheumatoid arthritis-associated interstitial lung disease. Chest. 2014 Mar 01; 145(3):454-463. PMID: 24590021.
      Citations: 16     Fields:    Translation:Humans
    107. Cullinane AR, Yeager C, Dorward H, Carmona-Rivera C, Wu HP, Moss J, O'Brien KJ, Nathan SD, Meyer KC, Rosas IO, Helip-Wooley A, Huizing M, Gahl WA, Gochuico BR. Dysregulation of galectin-3. Implications for Hermansky-Pudlak syndrome pulmonary fibrosis. Am J Respir Cell Mol Biol. 2014 Mar; 50(3):605-13. PMID: 24134621.
      Citations: 13     Fields:    Translation:HumansCells
    108. Nakahira K, Kyung SY, Rogers AJ, Gazourian L, Youn S, Massaro AF, Quintana C, Osorio JC, Wang Z, Zhao Y, Lawler LA, Christie JD, Meyer NJ, Mc Causland FR, Waikar SS, Waxman AB, Chung RT, Bueno R, Rosas IO, Fredenburgh LE, Baron RM, Christiani DC, Hunninghake GM, Choi AM. Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation. PLoS Med. 2013 Dec; 10(12):e1001577; discussion e1001577. PMID: 24391478.
      Citations: 117     Fields:    Translation:Humans
    109. Morse D, Rosas IO. Tobacco smoke-induced lung fibrosis and emphysema. Annu Rev Physiol. 2014; 76:493-513. PMID: 24274738.
      Citations: 17     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    110. Rosas IO, Kottmann RM, Kottman RM, Sime PJ. New light is shed on the enigmatic origin of the lung myofibroblast. Am J Respir Crit Care Med. 2013 Oct 01; 188(7):765-6. PMID: 24083856.
      Citations: 3     Fields:    Translation:AnimalsCells
    111. Shi Y, Gochuico BR, Yu G, Tang X, Osorio JC, Fernandez IE, Risquez CF, Patel AS, Shi Y, Wathelet MG, Goodwin AJ, Haspel JA, Ryter SW, Billings EM, Kaminski N, Morse D, Rosas IO. Syndecan-2 exerts antifibrotic effects by promoting caveolin-1-mediated transforming growth factor-ß receptor I internalization and inhibiting transforming growth factor-ß1 signaling. Am J Respir Crit Care Med. 2013 Oct 01; 188(7):831-41. PMID: 23924348.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    112. El-Chemaly S, Malide D, Yao J, Nathan SD, Rosas IO, Gahl WA, Moss J, Gochuico BR. Glucose transporter-1 distribution in fibrotic lung disease: association with [¹8F]-2-fluoro-2-deoxyglucose-PET scan uptake, inflammation, and neovascularization. Chest. 2013 Jun; 143(6):1685-1691. PMID: 23699745.
      Citations: 10     Fields:    Translation:Humans
    113. Hunninghake GM, Hatabu H, Okajima Y, Gao W, Dupuis J, Latourelle JC, Nishino M, Araki T, Zazueta OE, Kurugol S, Ross JC, San José Estépar R, Murphy E, Steele MP, Loyd JE, Schwarz MI, Fingerlin TE, Rosas IO, Washko GR, O'Connor GT, Schwartz DA. MUC5B promoter polymorphism and interstitial lung abnormalities. N Engl J Med. 2013 Jun 06; 368(23):2192-200. PMID: 23692170.
      Citations: 98     Fields:    Translation:Humans
    114. Mihalek AD, Rosas IO, Padera RF, Fuhlbrigge AL, Hunninghake GM, DeMeo DL, Camp PC, Goldberg HJ. Interstitial pneumonitis and the risk of chronic allograft rejection in lung transplant recipients. Chest. 2013 May; 143(5):1430-1435. PMID: 23715594.
      Citations: 2     Fields:    Translation:Humans
    115. Gansner JM, Rosas IO. Telomeres in lung disease. Transl Res. 2013 Dec; 162(6):343-52. PMID: 23618685.
      Citations: 16     Fields:    Translation:HumansCells
    116. Harlow L, Rosas IO, Gochuico BR, Mikuls TR, Dellaripa PF, Oddis CV, Ascherman DP. Identification of citrullinated hsp90 isoforms as novel autoantigens in rheumatoid arthritis-associated interstitial lung disease. Arthritis Rheum. 2013 Apr; 65(4):869-79. PMID: 23400887.
      Citations: 36     Fields:    Translation:HumansCells
    117. Rosas IO, Yang IV. The promise of epigenetic therapies in treatment of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2013 Feb 15; 187(4):336-8. PMID: 23418324.
      Citations: 3     Fields:    Translation:HumansAnimals
    118. Doyle TJ, Pinto-Plata V, Morse D, Celli BR, Rosas IO. The expanding role of biomarkers in the assessment of smoking-related parenchymal lung diseases. Chest. 2012 Oct; 142(4):1027-1034. PMID: 23032451.
      Citations: 14     Fields:    Translation:HumansPHPublic Health
    119. Yu G, Kovkarova-Naumovski E, Jara P, Parwani A, Kass D, Ruiz V, Lopez-Otín C, Rosas IO, Gibson KF, Cabrera S, Ramírez R, Yousem SA, Richards TJ, Chensny LJ, Selman M, Kaminski N, Pardo A. Matrix metalloproteinase-19 is a key regulator of lung fibrosis in mice and humans. Am J Respir Crit Care Med. 2012 Oct 15; 186(8):752-62. PMID: 22859522.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    120. Patel AS, Lin L, Geyer A, Haspel JA, An CH, Cao J, Rosas IO, Morse D. Autophagy in idiopathic pulmonary fibrosis. PLoS One. 2012; 7(7):e41394. PMID: 22815997.
      Citations: 108     Fields:    Translation:HumansAnimalsCells
    121. Shi Y, Cao J, Gao J, Zheng L, Goodwin A, An CH, Patel A, Lee JS, Duncan SR, Kaminski N, Pandit KV, Rosas IO, Choi AM, Morse D. Retinoic acid-related orphan receptor-a is induced in the setting of DNA damage and promotes pulmonary emphysema. Am J Respir Crit Care Med. 2012 Sep 01; 186(5):412-9. PMID: 22744720.
      Citations: 9     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    122. Gansner JM, Rosas IO, Ebert BL. Pulmonary fibrosis, bone marrow failure, and telomerase mutation. N Engl J Med. 2012 Apr 19; 366(16):1551-3. PMID: 22512499.
      Citations: 5     Fields:    Translation:HumansCells
    123. Doyle TJ, Hunninghake GM, Rosas IO. Subclinical interstitial lung disease: why you should care. Am J Respir Crit Care Med. 2012 Jun 01; 185(11):1147-53. PMID: 22366047.
      Citations: 37     Fields:    Translation:Humans
    124. Doyle TJ, Washko GR, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Divo MJ, Celli BR, Sciurba FC, Silverman EK, Hatabu H, Rosas IO, Hunninghake GM. Interstitial lung abnormalities and reduced exercise capacity. Am J Respir Crit Care Med. 2012 Apr 01; 185(7):756-62. PMID: 22268134.
      Citations: 31     Fields:    Translation:Humans
    125. Xu JF, Washko GR, Nakahira K, Hatabu H, Patel AS, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, Estépar RS, Diaz AA, Li HP, Qu JM, Himes BE, Come CE, D'Aco K, Martinez FJ, Han MK, Lynch DA, Crapo JD, Morse D, Ryter SW, Silverman EK, Rosas IO, Choi AM, Hunninghake GM. Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation. Am J Respir Crit Care Med. 2012 Mar 01; 185(5):547-56. PMID: 22246178.
      Citations: 37     Fields:    Translation:HumansAnimals
    126. Rosas IO, Yao J, Avila NA, Chow CK, Gahl WA, Gochuico BR. Automated quantification of high-resolution CT scan findings in individuals at risk for pulmonary fibrosis. Chest. 2011 Dec; 140(6):1590-1597. PMID: 21622544.
      Citations: 18     Fields:    Translation:Humans
    127. Washko GR, Hunninghake GM, Fernandez IE, Nishino M, Okajima Y, Yamashiro T, Ross JC, Estépar RS, Lynch DA, Brehm JM, Andriole KP, Diaz AA, Khorasani R, D'Aco K, Sciurba FC, Silverman EK, Hatabu H, Rosas IO. Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med. 2011 Mar 10; 364(10):897-906. PMID: 21388308.
      Citations: 143     Fields:    Translation:Humans
    128. Xue J, Gochuico BR, Alawad AS, Feghali-Bostwick CA, Noth I, Nathan SD, Rosen GD, Rosas IO, Dacic S, Ocak I, Fuhrman CR, Cuenco KT, Smith MA, Jacobs SS, Zeevi A, Morel PA, Pilewski JM, Valentine VG, Gibson KF, Kaminski N, Sciurba FC, Zhang Y, Duncan SR. The HLA class II Allele DRB1*1501 is over-represented in patients with idiopathic pulmonary fibrosis. PLoS One. 2011 Feb 23; 6(2):e14715. PMID: 21373184.
      Citations: 19     Fields:    Translation:Humans
    129. Wilson MS, Madala SK, Ramalingam TR, Gochuico BR, Rosas IO, Cheever AW, Wynn TA. Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent. J Exp Med. 2010 Mar 15; 207(3):535-52. PMID: 20176803.
      Citations: 240     Fields:    Translation:AnimalsCells
    130. Washko GR, Lynch DA, Matsuoka S, Ross JC, Umeoka S, Diaz A, Sciurba FC, Hunninghake GM, San José Estépar R, Silverman EK, Rosas IO, Hatabu H. Identification of early interstitial lung disease in smokers from the COPDGene Study. Acad Radiol. 2010 Jan; 17(1):48-53. PMID: 19781963.
      Citations: 66     Fields:    Translation:Humans
    131. Richards TJ, Eggebeen A, Gibson K, Yousem S, Fuhrman C, Gochuico BR, Fertig N, Oddis CV, Kaminski N, Rosas IO, Ascherman DP. Characterization and peripheral blood biomarker assessment of anti-Jo-1 antibody-positive interstitial lung disease. Arthritis Rheum. 2009 Jul; 60(7):2183-92. PMID: 19565490.
      Citations: 28     Fields:    Translation:Humans
    132. El-Chemaly S, Malide D, Zudaire E, Ikeda Y, Weinberg BA, Pacheco-Rodriguez G, Rosas IO, Aparicio M, Ren P, MacDonald SD, Wu HP, Nathan SD, Cuttitta F, McCoy JP, Gochuico BR, Moss J. Abnormal lymphangiogenesis in idiopathic pulmonary fibrosis with insights into cellular and molecular mechanisms. Proc Natl Acad Sci U S A. 2009 Mar 10; 106(10):3958-63. PMID: 19237567.
      Citations: 46     Fields:    Translation:HumansCells
    133. Kliment CR, Englert JM, Gochuico BR, Yu G, Kaminski N, Rosas I, Oury TD. Oxidative stress alters syndecan-1 distribution in lungs with pulmonary fibrosis. J Biol Chem. 2009 Feb 06; 284(6):3537-45. PMID: 19073610.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    134. Rosas IO, Richards TJ, Konishi K, Zhang Y, Gibson K, Lokshin AE, Lindell KO, Cisneros J, Macdonald SD, Pardo A, Sciurba F, Dauber J, Selman M, Gochuico BR, Kaminski N. MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis. PLoS Med. 2008 Apr 29; 5(4):e93. PMID: 18447576.
      Citations: 161     Fields:    Translation:Humans
    135. Gochuico BR, Avila NA, Chow CK, Novero LJ, Wu HP, Ren P, MacDonald SD, Travis WD, Stylianou MP, Rosas IO. Progressive preclinical interstitial lung disease in rheumatoid arthritis. Arch Intern Med. 2008 Jan 28; 168(2):159-66. PMID: 18227362.
      Citations: 85     Fields:    Translation:HumansCTClinical Trials
    136. Rosas IO, Ren P, Avila NA, Chow CK, Franks TJ, Travis WD, McCoy JP, May RM, Wu HP, Nguyen DM, Arcos-Burgos M, MacDonald SD, Gochuico BR. Early interstitial lung disease in familial pulmonary fibrosis. Am J Respir Crit Care Med. 2007 Oct 01; 176(7):698-705. PMID: 17641157.
      Citations: 55     Fields:    Translation:Humans
    137. Ren P, Rosas IO, Macdonald SD, Wu HP, Billings EM, Gochuico BR. Impairment of alveolar macrophage transcription in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2007 Jun 01; 175(11):1151-7. PMID: 17332483.
      Citations: 13     Fields:    Translation:HumansCells
    138. Rosas IO, Kaminski N. When it comes to genes--IPF or NSIP, familial or sporadic--they're all the same. Am J Respir Crit Care Med. 2007 Jan 01; 175(1):5-6. PMID: 17179494.
      Citations: 5     Fields:    Translation:Humans
    139. Kaminski N, Rosas IO. Gene expression profiling as a window into idiopathic pulmonary fibrosis pathogenesis: can we identify the right target genes? Proc Am Thorac Soc. 2006 Jun; 3(4):339-44. PMID: 16738198.
      Citations: 30     Fields:    Translation:Humans
    ROSAS's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (526)
    Explore
    _
    Co-Authors (3)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _