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HUI ZHENG

TitleDirector
InstitutionBaylor College of Medicine
DepartmentHuffington Center on Aging
DivisionHuffington Ctr on Aging
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Human Genetics
    DivisionMolecular & Human Genetics

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentHuffington Center on Aging
    DivisionHuffington Ctr on Aging

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience
    DivisionNeuroscience


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    R01NS040039     (ZHENG, HUI)Apr 20, 2000 - Jan 31, 2009
    NIH/NINDS
    Presenilins in tumorigenesis and neurodegeneration
    Role: Principal Investigator

    R01AG020670     (ZHENG, HUI)Apr 1, 2002 - Mar 31, 2022
    NIH/NIA
    Knockin Mouse Models of Alzheimer's Disease
    Role: Principal Investigator

    R01AG021141     (ZHENG, HUI)Sep 1, 2002 - Aug 31, 2008
    NIH/NIA
    Defining presenilin-beta-catenin pathway in vivo
    Role: Principal Investigator

    R01AG032051     (ZHENG, HUI)Mar 1, 2008 - Jun 30, 2018
    NIH/NIA
    Pathophysiology of APP in vivo
    Role: Principal Investigator

    R01AG033467     (ZHENG, HUI)Feb 1, 2009 - Jan 31, 2014
    NIH/NIA
    Role of APP in Synaptic Regulation
    Role: Principal Investigator

    R01NS076117     (LI, YUEMING)Jun 1, 2011 - May 31, 2016
    NIH/NINDS
    Mechanism and therapy of AB-42-specific gamma-secretase
    Role: Co-Principal Investigator

    R01NS093652     (ZHENG, HUI)Jul 1, 2015 - Jun 30, 2020
    NIH/NINDS
    Role of TFEB in Tauopathy
    Role: Principal Investigator

    RF1AG054111     (ZHENG, HUI)Aug 15, 2016 - Jun 30, 2021
    NIH/NIA
    Decoding the role of diverse astrocyte populations in aging and AD
    Role: Principal Investigator

    R01AG057509     (ZHENG, HUI)Sep 30, 2017 - May 31, 2022
    NIH/NIA
    Convergence of tauopathy and Huntington's disease through selective autophagy
    Role: Principal Investigator

    R01AG062257     (ZHENG, HUI)Sep 15, 2018 - May 31, 2023
    NIH/NIA
    Targeting a lipid-mediated pro-longevity pathway as Alzheimer's therapy
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wu Y, Du S, Johnson JL, Tung HY, Landers CT, Liu Y, Seman BG, Wheeler RT, Costa-Mattioli M, Kheradmand F, Zheng H, Corry DB. Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits. Nat Commun. 2019 01 04; 10(1):58. PMID: 30610193.
      View in: PubMed
    2. Litvinchuk A, Wan YW, Swartzlander DB, Chen F, Cole A, Propson NE, Wang Q, Zhang B, Liu Z, Zheng H. Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer's Disease. Neuron. 2018 12 19; 100(6):1337-1353.e5. PMID: 30415998.
      View in: PubMed
    3. Cao W, Zheng H. Correction to: Peripheral immune system in aging and Alzheimer's disease. Mol Neurodegener. 2018 10 24; 13(1):58. PMID: 30355319.
      View in: PubMed
    4. Xu Y, Zhang S, Zheng H. The cargo receptor SQSTM1 ameliorates neurofibrillary tangle pathology and spreading through selective targeting of pathological MAPT (microtubule associated protein tau). Autophagy. 2019 Apr; 15(4):583-598. PMID: 30290707.
      View in: PubMed
    5. Cao W, Zheng H. Peripheral immune system in aging and Alzheimer's disease. Mol Neurodegener. 2018 10 03; 13(1):51. PMID: 30285785.
      View in: PubMed
    6. Martini-Stoica H, Cole AL, Swartzlander DB, Chen F, Wan YW, Bajaj L, Bader DA, Lee VMY, Trojanowski JQ, Liu Z, Sardiello M, Zheng H. TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading. J Exp Med. 2018 09 03; 215(9):2355-2377. PMID: 30108137.
      View in: PubMed
    7. Jankowsky JL, Zheng H. Practical considerations for choosing a mouse model of Alzheimer's disease. Mol Neurodegener. 2017 12 22; 12(1):89. PMID: 29273078.
      View in: PubMed
    8. Li Y, Chen Z, Gao Y, Pan G, Zheng H, Zhang Y, Xu H, Bu G, Zheng H. Synaptic Adhesion Molecule Pcdh-?C5 Mediates Synaptic Dysfunction in Alzheimer's Disease. J Neurosci. 2017 09 20; 37(38):9259-9268. PMID: 28842416.
      View in: PubMed
    9. Wang B, Li H, Mutlu SA, Bowser DA, Moore MJ, Wang MC, Zheng H. The Amyloid Precursor Protein Is a Conserved Receptor for Slit to Mediate Axon Guidance. eNeuro. 2017 May-Jun; 4(3). PMID: 28785723.
      View in: PubMed
    10. Lee JH, Lin L, Xu P, Saito K, Wei Q, Meadows AG, Bongmba OY, Pradhan G, Zheng H, Xu Y, Sun Y. Neuronal Deletion of Ghrelin Receptor Almost Completely Prevents Diet-Induced Obesity. Diabetes. 2016 08; 65(8):2169-78. PMID: 27207529.
      View in: PubMed
    11. Xu Y, Martini-Stoica H, Zheng H. A seeding based cellular assay of tauopathy. Mol Neurodegener. 2016 Apr 26; 11:32. PMID: 27112488.
      View in: PubMed
    12. Martini-Stoica H, Xu Y, Ballabio A, Zheng H. The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective. Trends Neurosci. 2016 Apr; 39(4):221-234. PMID: 26968346.
      View in: PubMed
    13. Lian H, Zheng H. Signaling pathways regulating neuron-glia interaction and their implications in Alzheimer's disease. J Neurochem. 2016 Feb; 136(3):475-91. PMID: 26546579.
      View in: PubMed
    14. Justice NJ, Huang L, Tian JB, Cole A, Pruski M, Hunt AJ, Flores R, Zhu MX, Arenkiel BR, Zheng H. Posttraumatic stress disorder-like induction elevates ß-amyloid levels, which directly activates corticotropin-releasing factor neurons to exacerbate stress responses. J Neurosci. 2015 Feb 11; 35(6):2612-23. PMID: 25673853.
      View in: PubMed
    15. Lian H, Yang L, Cole A, Sun L, Chiang AC, Fowler SW, Shim DJ, Rodriguez-Rivera J, Taglialatela G, Jankowsky JL, Lu HC, Zheng H. NF?B-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer's disease. Neuron. 2015 Jan 07; 85(1):101-115. PMID: 25533482.
      View in: PubMed
    16. Wang B, Wang Z, Sun L, Yang L, Li H, Cole AL, Rodriguez-Rivera J, Lu HC, Zheng H. The amyloid precursor protein controls adult hippocampal neurogenesis through GABAergic interneurons. J Neurosci. 2014 Oct 01; 34(40):13314-25. PMID: 25274811.
      View in: PubMed
    17. Polito VA, Li H, Martini-Stoica H, Wang B, Yang L, Xu Y, Swartzlander DB, Palmieri M, di Ronza A, Lee VM, Sardiello M, Ballabio A, Zheng H. Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB. EMBO Mol Med. 2014 Sep; 6(9):1142-60. PMID: 25069841.
      View in: PubMed
    18. Born HA, Kim JY, Savjani RR, Das P, Dabaghian YA, Guo Q, Yoo JW, Schuler DR, Cirrito JR, Zheng H, Golde TE, Noebels JL, Jankowsky JL. Genetic suppression of transgenic APP rescues Hypersynchronous network activity in a mouse model of Alzeimer's disease. J Neurosci. 2014 Mar 12; 34(11):3826-40. PMID: 24623762.
      View in: PubMed
    19. Guo Q, Li H, Cole AL, Hur JY, Li Y, Zheng H. Modeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aß and tau. PLoS One. 2013; 8(11):e80706. PMID: 24278307.
      View in: PubMed
    20. Lian H, Shim DJ, Gaddam SS, Rodriguez-Rivera J, Bitner BR, Pautler RG, Robertson CS, Zheng H. I?Ba deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery. Mol Neurodegener. 2012 Sep 19; 7:47. PMID: 22992283.
      View in: PubMed
    21. Wiese M, Antebi A, Zheng H. Regulation of neuronal APL-1 expression by cholesterol starvation. PLoS One. 2012; 7(2):e32038. PMID: 22363792.
      View in: PubMed
    22. Guo Q, Zheng H, Justice NJ. Central CRF system perturbation in an Alzheimer's disease knockin mouse model. Neurobiol Aging. 2012 Nov; 33(11):2678-91. PMID: 22336193.
      View in: PubMed
    23. Wang Z, Yang L, Zheng H. Role of APP and Aß in synaptic physiology. Curr Alzheimer Res. 2012 Feb; 9(2):217-26. PMID: 21605029.
      View in: PubMed
    24. Guo Q, Li H, Gaddam SS, Justice NJ, Robertson CS, Zheng H. Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives. J Biol Chem. 2012 Jan 20; 287(4):2437-45. PMID: 22144675.
      View in: PubMed
    25. Wang B, Harrison W, Overbeek PA, Zheng H. Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development. Development. 2011 Oct; 138(20):4487-97. PMID: 21937600.
      View in: PubMed
    26. Guo Q, Wang Z, Li H, Wiese M, Zheng H. APP physiological and pathophysiological functions: insights from animal models. Cell Res. 2012 Jan; 22(1):78-89. PMID: 21769132.
      View in: PubMed
    27. Shim DJ, Yang L, Reed JG, Noebels JL, Chiao PJ, Zheng H. Disruption of the NF-?B/I?Ba Autoinhibitory Loop Improves Cognitive Performance and Promotes Hyperexcitability of Hippocampal Neurons. Mol Neurodegener. 2011 Jun 10; 6:42. PMID: 21663635.
      View in: PubMed
    28. Barbagallo AP, Wang Z, Zheng H, D'Adamio L. The intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function. PLoS One. 2011 Mar 22; 6(3):e18006. PMID: 21445342.
      View in: PubMed
    29. Barbagallo AP, Wang Z, Zheng H, D'Adamio L. A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function. J Biol Chem. 2011 Mar 18; 286(11):8717-21. PMID: 21266574.
      View in: PubMed
    30. Peethumnongsin E, Yang L, Kallhoff-Muñoz V, Hu L, Takashima A, Pautler RG, Zheng H. Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function. J Neurosci. 2010 Oct 06; 30(40):13409-18. PMID: 20926667.
      View in: PubMed
    31. Wiese M, Antebi A, Zheng H. Intracellular trafficking and synaptic function of APL-1 in Caenorhabditis elegans. PLoS One. 2010 Sep 20; 5(9). PMID: 20862215.
      View in: PubMed
    32. Li H, Wang B, Wang Z, Guo Q, Tabuchi K, Hammer RE, Südhof TC, Zheng H. Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP. Proc Natl Acad Sci U S A. 2010 Oct 05; 107(40):17362-7. PMID: 20855613.
      View in: PubMed
    33. Peng B, Ling J, Lee AJ, Wang Z, Chang Z, Jin W, Kang Y, Zhang R, Shim D, Wang H, Fleming JB, Zheng H, Sun SC, Chiao PJ. Defective feedback regulation of NF-kappaB underlies Sjogren's syndrome in mice with mutated kappaB enhancers of the IkappaBalpha promoter. Proc Natl Acad Sci U S A. 2010 Aug 24; 107(34):15193-8. PMID: 20696914.
      View in: PubMed
    34. Li H, Wang Z, Wang B, Guo Q, Dolios G, Tabuchi K, Hammer RE, Südhof TC, Wang R, Zheng H. Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis. J Biol Chem. 2010 Oct 01; 285(40):30598-605. PMID: 20693289.
      View in: PubMed
    35. Umeda T, Mori H, Zheng H, Tomiyama T. Regulation of cholesterol efflux by amyloid beta secretion. J Neurosci Res. 2010 Jul; 88(9):1985-94. PMID: 20155813.
      View in: PubMed
    36. Hernandez CM, Kayed R, Zheng H, Sweatt JD, Dineley KT. Loss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease. J Neurosci. 2010 Feb 17; 30(7):2442-53. PMID: 20164328.
      View in: PubMed
    37. Smith KD, Peethumnongsin E, Lin H, Zheng H, Pautler RG. Increased Human Wildtype Tau Attenuates Axonal Transport Deficits Caused by Loss of APP in Mouse Models. Magn Reson Insights. 2010; 4:11-18. PMID: 20798780.
      View in: PubMed
    38. Yang L, Wang Z, Wang B, Justice NJ, Zheng H. Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity. J Neurosci. 2009 Dec 16; 29(50):15660-8. PMID: 20016080.
      View in: PubMed
    39. Shelton CC, Zhu L, Chau D, Yang L, Wang R, Djaballah H, Zheng H, Li YM. Modulation of gamma-secretase specificity using small molecule allosteric inhibitors. Proc Natl Acad Sci U S A. 2009 Dec 01; 106(48):20228-33. PMID: 19906985.
      View in: PubMed
    40. Wang Z, Wang B, Yang L, Guo Q, Aithmitti N, Songyang Z, Zheng H. Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis. J Neurosci. 2009 Sep 02; 29(35):10788-801. PMID: 19726636.
      View in: PubMed
    41. Placanica L, Tarassishin L, Yang G, Peethumnongsin E, Kim SH, Zheng H, Sisodia SS, Li YM. Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes. J Biol Chem. 2009 Jan 30; 284(5):2967-77. PMID: 19036728.
      View in: PubMed
    42. Kallhoff-Munoz V, Hu L, Chen X, Pautler RG, Zheng H. Genetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death. J Neurosci. 2008 Oct 29; 28(44):11421-31. PMID: 18971484.
      View in: PubMed
    43. Engin F, Yao Z, Yang T, Zhou G, Bertin T, Jiang MM, Chen Y, Wang L, Zheng H, Sutton RE, Boyce BF, Lee B. Dimorphic effects of Notch signaling in bone homeostasis. Nat Med. 2008 Mar; 14(3):299-305. PMID: 18297084.
      View in: PubMed
    44. Yang L, Wang B, Long C, Wu G, Zheng H. Increased asynchronous release and aberrant calcium channel activation in amyloid precursor protein deficient neuromuscular synapses. Neuroscience. 2007 Nov 23; 149(4):768-78. PMID: 17919826.
      View in: PubMed
    45. Repetto E, Yoon IS, Zheng H, Kang DE. Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway. J Biol Chem. 2007 Oct 26; 282(43):31504-16. PMID: 17716970.
      View in: PubMed
    46. Wang B, Yang L, Wang Z, Zheng H. Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):14140-5. PMID: 17709753.
      View in: PubMed
    47. Kallhoff V, Peethumnongsin E, Zheng H. Lack of alpha-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease. Mol Neurodegener. 2007 Mar 16; 2:6. PMID: 17367539.
      View in: PubMed
    48. Smith KD, Kallhoff V, Zheng H, Pautler RG. In vivo axonal transport rates decrease in a mouse model of Alzheimer's disease. Neuroimage. 2007 May 01; 35(4):1401-8. PMID: 17369054.
      View in: PubMed
    49. Zheng H, Koo EH. The amyloid precursor protein: beyond amyloid. Mol Neurodegener. 2006 Jul 03; 1:5. PMID: 16930452.
      View in: PubMed
    50. Deng Y, Tarassishin L, Kallhoff V, Peethumnongsin E, Wu L, Li YM, Zheng H. Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology. J Neurosci. 2006 Apr 05; 26(14):3845-54. PMID: 16597739.
      View in: PubMed
    51. Wang R, Wang B, He W, Zheng H. Wild-type presenilin 1 protects against Alzheimer disease mutation-induced amyloid pathology. J Biol Chem. 2006 Jun 02; 281(22):15330-6. PMID: 16574645.
      View in: PubMed
    52. Cai D, Zhong M, Wang R, Netzer WJ, Shields D, Zheng H, Sisodia SS, Foster DA, Gorelick FS, Xu H, Greengard P. Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons. Proc Natl Acad Sci U S A. 2006 Feb 07; 103(6):1936-40. PMID: 16449385.
      View in: PubMed
    53. Wang R, Tang P, Wang P, Boissy RE, Zheng H. Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation. Proc Natl Acad Sci U S A. 2006 Jan 10; 103(2):353-8. PMID: 16384915.
      View in: PubMed
    54. Han P, Dou F, Li F, Zhang X, Zhang YW, Zheng H, Lipton SA, Xu H, Liao FF. Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: a novel excitoprotective mechanism involving modulation of tau phosphorylation. J Neurosci. 2005 Dec 14; 25(50):11542-52. PMID: 16354912.
      View in: PubMed
    55. Wang P, Yang G, Mosier DR, Chang P, Zaidi T, Gong YD, Zhao NM, Dominguez B, Lee KF, Gan WB, Zheng H. Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2. J Neurosci. 2005 Feb 02; 25(5):1219-25. PMID: 15689559.
      View in: PubMed
    56. Esselens C, Oorschot V, Baert V, Raemaekers T, Spittaels K, Serneels L, Zheng H, Saftig P, De Strooper B, Klumperman J, Annaert W. Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway. J Cell Biol. 2004 Sep 27; 166(7):1041-54. PMID: 15452145.
      View in: PubMed
    57. Qyang Y, Chambers SM, Wang P, Xia X, Chen X, Goodell MA, Zheng H. Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage. Biochemistry. 2004 May 11; 43(18):5352-9. PMID: 15122901.
      View in: PubMed
    58. Sun Y, Wang P, Zheng H, Smith RG. Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4679-84. PMID: 15070777.
      View in: PubMed
    59. Wang R, Dineley KT, Sweatt JD, Zheng H. Presenilin 1 familial Alzheimer's disease mutation leads to defective associative learning and impaired adult neurogenesis. Neuroscience. 2004; 126(2):305-12. PMID: 15207348.
      View in: PubMed
    60. Wang P, Pereira FA, Beasley D, Zheng H. Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis. Development. 2003 Oct; 130(20):5019-29. PMID: 12930775.
      View in: PubMed
    61. Cai D, Leem JY, Greenfield JP, Wang P, Kim BS, Wang R, Lopes KO, Kim SH, Zheng H, Greengard P, Sisodia SS, Thinakaran G, Xu H. Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein. J Biol Chem. 2003 Jan 31; 278(5):3446-54. PMID: 12435726.
      View in: PubMed
    62. Xia X, Wang P, Sun X, Soriano S, Shum WK, Yamaguchi H, Trumbauer ME, Takashima A, Koo EH, Zheng H. The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8760-5. PMID: 12070348.
      View in: PubMed
    63. Dineley KT, Xia X, Bui D, Sweatt JD, Zheng H. Accelerated plaque accumulation, associative learning deficits, and up-regulation of alpha 7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins. J Biol Chem. 2002 Jun 21; 277(25):22768-80. PMID: 11912199.
      View in: PubMed
    64. Morton RA, Kuenzi FM, Fitzjohn SM, Rosahl TW, Smith D, Zheng H, Shearman M, Collingridge GL, Seabrook GR. Impairment in hippocampal long-term potentiation in mice under-expressing the Alzheimer's disease related gene presenilin-1. Neurosci Lett. 2002 Feb 08; 319(1):37-40. PMID: 11814648.
      View in: PubMed
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