TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
Houston, TX 77030
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    R01HL098839     (WU, HUAIZHU)Apr 1, 2010 - Mar 31, 2020
    Monocyte Activation and the Role of CD11c in obesity-linked metabolic syndrome
    Role: Principal Investigator

    R01DK121348     (WU, HUAIZHU)Jan 27, 2020 - Dec 31, 2023
    Regulation of Type 1 Inflammation in Diet-induced Obesity
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wu H, Ballantyne CM. Skeletal muscle inflammation and insulin resistance in obesity. J Clin Invest. 2017 01 03; 127(1):43-54. PMID: 28045398.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    2. Khan IM, Pokharel Y, Dadu RT, Lewis DE, Hoogeveen RC, Wu H, Ballantyne CM. Postprandial Monocyte Activation in Individuals With Metabolic Syndrome. J Clin Endocrinol Metab. 2016 11; 101(11):4195-4204. PMID: 27575945.
      Citations: 17     Fields:    Translation:HumansCells
    3. Zhou H, Ran Y, Da Q, Shaw TS, Shang D, Reddy AK, López JA, Ballantyne CM, Ware J, Wu H, Peng Y. Defective Association of the Platelet Glycoprotein Ib-IX Complex with the Glycosphingolipid-Enriched Membrane Domain Inhibits Murine Thrombus and Atheroma Formation. J Immunol. 2016 07 01; 197(1):288-95. PMID: 27206768.
      Citations: 5     Fields:    Translation:AnimalsCells
    4. Lin L, Lee JH, Buras ED, Yu K, Wang R, Smith CW, Wu H, Sheikh-Hamad D, Sun Y. Ghrelin receptor regulates adipose tissue inflammation in aging. Aging (Albany NY). 2016 Jan; 8(1):178-91. PMID: 26837433.
      Citations: 24     Fields:    Translation:AnimalsCells
    5. Foster GA, Xu L, Chidambaram AA, Soderberg SR, Armstrong EJ, Wu H, Simon SI. CD11c/CD18 Signals Very Late Antigen-4 Activation To Initiate Foamy Monocyte Recruitment during the Onset of Hypercholesterolemia. J Immunol. 2015 Dec 01; 195(11):5380-92. PMID: 26519532.
      Citations: 13     Fields:    Translation:AnimalsCells
    6. Xu L, Dai Perrard X, Perrard JL, Yang D, Xiao X, Teng BB, Simon SI, Ballantyne CM, Wu H. Foamy monocytes form early and contribute to nascent atherosclerosis in mice with hypercholesterolemia. Arterioscler Thromb Vasc Biol. 2015 Aug; 35(8):1787-97. PMID: 26112011.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    7. Khan IM, Perrard XY, Brunner G, Lui H, Sparks LM, Smith SR, Wang X, Shi ZZ, Lewis DE, Wu H, Ballantyne CM. Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance. Int J Obes (Lond). 2015 Nov; 39(11):1607-18. PMID: 26041698.
      Citations: 46     Fields:    Translation:AnimalsCells
    8. Wu H, Ballantyne CM. Inflammation versus host defense in obesity. Cell Metab. 2014 Nov 04; 20(5):708-709. PMID: 25440053.
      Citations: 3     Fields:    Translation:Animals
    9. Wooten JS, Wu H, Raya J, Perrard XD, Gaubatz J, Hoogeveen RC. The Influence of an Obesogenic Diet on Oxysterol Metabolism in C57BL/6J Mice. Cholesterol. 2014; 2014:843468. PMID: 24672716.
      Citations: 9     
    10. Khan IM, Dai Perrard XY, Perrard JL, Mansoori A, Wayne Smith C, Wu H, Ballantyne CM. Attenuated adipose tissue and skeletal muscle inflammation in obese mice with combined CD4+ and CD8+ T cell deficiency. Atherosclerosis. 2014 Apr; 233(2):419-428. PMID: 24530773.
      Citations: 31     Fields:    Translation:AnimalsCells
    11. Lim H, Kim YU, Sun H, Lee JH, Reynolds JM, Hanabuchi S, Wu H, Teng BB, Chung Y. Proatherogenic conditions promote autoimmune T helper 17 cell responses in vivo. Immunity. 2014 Jan 16; 40(1):153-65. PMID: 24412615.
      Citations: 45     Fields:    Translation:AnimalsCells
    12. Ma X, Lin L, Yue J, Pradhan G, Qin G, Minze LJ, Wu H, Sheikh-Hamad D, Smith CW, Sun Y. Ghrelin receptor regulates HFCS-induced adipose inflammation and insulin resistance. Nutr Diabetes. 2013 Dec 23; 3:e99. PMID: 24366371.
      Citations: 10     Fields:    
    13. Xu L, Ping F, Yin J, Xiao X, Xiang H, Ballantyne CM, Wu H, Li M. Elevated plasma SPARC levels are associated with insulin resistance, dyslipidemia, and inflammation in gestational diabetes mellitus. PLoS One. 2013; 8(12):e81615. PMID: 24349098.
      Citations: 16     Fields:    Translation:Humans
    14. Jiang E, Perrard XD, Yang D, Khan IM, Perrard JL, Smith CW, Ballantyne CM, Wu H. Essential role of CD11a in CD8+ T-cell accumulation and activation in adipose tissue. Arterioscler Thromb Vasc Biol. 2014 Jan; 34(1):34-43. PMID: 24158516.
      Citations: 25     Fields:    Translation:AnimalsCells
    15. Wang J, Perrard XD, Perrard JL, Mukherjee A, Rosales C, Chen Y, Smith CW, Pownall HJ, Ballantyne CM, Wu H. ApoE and the role of very low density lipoproteins in adipose tissue inflammation. Atherosclerosis. 2012 Aug; 223(2):342-9. PMID: 22770993.
      Citations: 13     Fields:    Translation:Animals
    16. Liu MY, Zhou Z, Ma R, Tao Z, Choi H, Bergeron AL, Wu H, Dong JF. Gender-dependent up-regulation of ADAMTS-13 in mice with obesity and hypercholesterolemia. Thromb Res. 2012 Apr; 129(4):536-9. PMID: 22192156.
      Citations: 2     Fields:    Translation:AnimalsCells
    17. Wang Q, Perrard XD, Perrard JL, Mansoori A, Raya JL, Hoogeveen R, Smith CW, Ballantyne CM, Wu H. Differential effect of weight loss with low-fat diet or high-fat diet restriction on inflammation in the liver and adipose tissue of mice with diet-induced obesity. Atherosclerosis. 2011 Nov; 219(1):100-8. PMID: 21824616.
      Citations: 15     Fields:    Translation:AnimalsCells
    18. Gower RM, Wu H, Foster GA, Devaraj S, Jialal I, Ballantyne CM, Knowlton AA, Simon SI. CD11c/CD18 expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to vascular cell adhesion molecule-1. Arterioscler Thromb Vasc Biol. 2011 Jan; 31(1):160-6. PMID: 21030716.
      Citations: 61     Fields:    Translation:HumansCells
    19. Wang Q, Perrard XD, Perrard JL, Mansoori A, Smith CW, Ballantyne CM, Wu H. Effect of the cannabinoid receptor-1 antagonist rimonabant on inflammation in mice with diet-induced obesity. Obesity (Silver Spring). 2011 Mar; 19(3):505-13. PMID: 20885384.
      Citations: 8     Fields:    Translation:Animals
    20. Wu H, Perrard XD, Wang Q, Perrard JL, Polsani VR, Jones PH, Smith CW, Ballantyne CM. CD11c expression in adipose tissue and blood and its role in diet-induced obesity. Arterioscler Thromb Vasc Biol. 2010 Feb; 30(2):186-92. PMID: 19910635.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    21. Wu H, Ballantyne CM. Inflammation, adipose tissue, and T cells: what is the "straight skinny" on lean versus fat mice? Circ Res. 2009 Jul 17; 105(2):e3-4; author reply e5. PMID: 19608985.
      Citations:    Fields:    Translation:HumansAnimalsCells
    22. Wu H, Gower RM, Wang H, Perrard XY, Ma R, Bullard DC, Burns AR, Paul A, Smith CW, Simon SI, Ballantyne CM. Functional role of CD11c+ monocytes in atherogenesis associated with hypercholesterolemia. Circulation. 2009 May 26; 119(20):2708-17. PMID: 19433759.
      Citations: 110     Fields:    Translation:AnimalsCells
    23. Wu H, Ghosh S, Perrard XD, Feng L, Garcia GE, Perrard JL, Sweeney JF, Peterson LE, Chan L, Smith CW, Ballantyne CM. T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity. Circulation. 2007 Feb 27; 115(8):1029-38. PMID: 17296858.
      Citations: 281     Fields:    Translation:HumansAnimalsCells
    24. Vasudevan AR, Wu H, Xydakis AM, Jones PH, Smith EO, Sweeney JF, Corry DB, Ballantyne CM. Eotaxin and obesity. J Clin Endocrinol Metab. 2006 Jan; 91(1):256-61. PMID: 16263831.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    25. McDonald HR, Goldstein M, Loewenstein A, Pieramici DJ, Khawly JA. Diagnostic and therapeutic challenges. Retina. 2005 Apr-May; 25(3):355-9; discussion 359-60. PMID: 15805914.
      Citations:    Fields:    Translation:Humans
    26. Park P, Khawly JA, Kearney DL, Altman CA, Yen KG. Bilateral endogenous endophthalmitis secondary to endocarditis with negative transesophageal echocardiogram. Am J Ophthalmol. 2004 Jul; 138(1):151-3. PMID: 15234302.
      Citations:    Fields:    Translation:Humans
    27. Wu H, Rodgers JR, Perrard XY, Perrard JL, Prince JE, Abe Y, Davis BK, Dietsch G, Smith CW, Ballantyne CM. Deficiency of CD11b or CD11d results in reduced staphylococcal enterotoxin-induced T cell response and T cell phenotypic changes. J Immunol. 2004 Jul 01; 173(1):297-306. PMID: 15210787.
      Citations: 36     Fields:    Translation:AnimalsCells
    28. Wu H, Prince JE, Brayton CF, Shah C, Zeve D, Gregory SH, Smith CW, Ballantyne CM. Host resistance of CD18 knockout mice against systemic infection with Listeria monocytogenes. Infect Immun. 2003 Oct; 71(10):5986-93. PMID: 14500519.
      Citations: 6     Fields:    Translation:AnimalsCells
    29. Wu H, Li J, Peng L, Liu H, Wu W, Zhou Y, Hou Q, Kong D. Anti-human platelet tetraspanin (CD9) monoclonal antibodies induce platelet integrin alpha IIb beta 3 activation in a Fc receptor-independent fashion. Chin Med J (Engl). 2001 Jan; 114(1):14-8. PMID: 11779428.
      Citations:    Fields:    Translation:Humans
    30. Haupert CL, Postel EA, Khawly JA. Posttraumatic endophthalmitis due to CDC coryneform group A-3 bacteria. Retina. 2000; 20(4):412-3. PMID: 10950428.
      Citations:    Fields:    Translation:HumansCells
    31. Peng L, Li J, Wu H. [Study on conformational changes of GP IIb/IIIa complex during platelet activation]. Zhonghua Xue Ye Xue Za Zhi. 1999 Sep; 20(9):459-61. PMID: 11721407.
      Citations:    Fields:    Translation:HumansCells
    32. Wu H, Li J, Peng L. [Characteristics of human platelet fibrinogen receptors regulated by anti-CD9 monoclonal antibodies]. Zhonghua Xue Ye Xue Za Zhi. 1999 Sep; 20(9):456-8. PMID: 11721406.
      Citations:    Fields:    Translation:HumansCells
    33. Wu H, Peng L, Li J, Wu W, Hou Q, Liu H, Wang M. Reversible exposure of human platelet fibrinogen receptors by antiplatelet tetraspanin monoclonal antibodies via induction of a conformational change in membrane glycoprotein IIb/IIIa complex. Thromb Res. 1999 Sep 01; 95(5):245-53. PMID: 10515289.
      Citations:    Fields:    Translation:HumansCells
    34. Khawly JA, Matthews JD, Machemer R. Appearance and rapid growth of retinal tumor (reactive astrocytic hyperplasia?). Graefes Arch Clin Exp Ophthalmol. 1999 Jan; 237(1):78-81. PMID: 9951646.
      Citations: 3     Fields:    Translation:Humans
    35. Khawly JA, Lambert RJ, Jaffe GJ. Intraocular lens changes after short- and long-term exposure to intraocular silicone oil. An in vivo study. Ophthalmology. 1998 Jul; 105(7):1227-33. PMID: 9663226.
      Citations: 4     Fields:    Translation:Animals
    36. Holck DE, Dutton JJ, Proia A, Khawly J, Mittra R, Dev S, Imami N. Rate of vascularization of coralline hydroxyapatite spherical implants pretreated with saline/gentamicin, rTGF-beta 2, and autogenous plasma. Ophthalmic Plast Reconstr Surg. 1998 Mar; 14(2):73-80. PMID: 9558662.
      Citations: 1     Fields:    Translation:Animals
    37. Khawly JA, McCuen BW. A tribute to Robert Machemer, MD, on the occasion of his retirement. Retina. 1998; 18(3):202-3, 293-4. PMID: 9654409.
      Citations: 1     Fields:    
    38. Yang CS, Khawly JA, Hainsworth DP, Chen SN, Ashton P, Guo H, Jaffe GJ. An intravitreal sustained-release triamcinolone and 5-fluorouracil codrug in the treatment of experimental proliferative vitreoretinopathy. Arch Ophthalmol. 1998 Jan; 116(1):69-77. PMID: 9445210.
      Citations: 20     Fields:    Translation:Animals
    39. Peng L, Li JZ, Wu HZ, Wang MJ. The activation of human platelets mediated by two monoclonal antibodies raised against CD9. Thromb Res. 1997 Jul 01; 87(1):65-73. PMID: 9253801.
      Citations: 1     Fields:    Translation:Humans
    40. Rubin P, Hulette C, Khawly JA, Elkordy M, Hussein A, Vredenburgh JJ, Jaffe GJ, Peters WP. Ocular toxicity following high dose chemotherapy and autologous transplant. Bone Marrow Transplant. 1996 Jul; 18(1):253-6. PMID: 8832031.
      Citations: 1     Fields:    Translation:Humans
    41. Khawly JA, Ferrone PJ, Holck DE. Choroidal hemorrhage associated with systemic tissue plasminogen activator. Am J Ophthalmol. 1996 May; 121(5):577-8. PMID: 8610807.
      Citations: 5     Fields:    Translation:Humans
    42. Wu H, Li J, Peng L, Teng B, Zhai Z. Effect of 764-3 on aggregation and calcium movements in aequorin-loaded human platelets. Chin Med Sci J. 1996 Mar; 11(1):49-52. PMID: 9206120.
      Citations:    Fields:    Translation:HumansCells
    43. Khawly JA, Rubin P, Petros W, Peters WP, Jaffe GJ. Retinopathy and optic neuropathy in bone marrow transplantation for breast cancer. Ophthalmology. 1996 Jan; 103(1):87-95. PMID: 8628565.
      Citations: 2     Fields:    Translation:Humans
    44. Peng L, Li J, Wu H, Teng B. [Characterization of platelet activation induced by CD9 McAbs]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 1995 Oct; 17(5):365-70. PMID: 8706172.
      Citations:    Fields:    Translation:HumansCells
    45. Khawly JA, Imami N, Shields MB. Glaucoma associated with the nevus of Ota. Arch Ophthalmol. 1995 Sep; 113(9):1208-9. PMID: 7661759.
      Citations: 2     Fields:    Translation:Humans
    46. Khawly JA, Shields MB. Metastatic carcinoma manifesting as angle-closure glaucoma. Am J Ophthalmol. 1994 Jul 15; 118(1):116-7. PMID: 8023864.
      Citations:    Fields:    Translation:Humans
    47. Khawly JA, Pollock SC. Litten's sign (Roth's spots) in bacterial endocarditis. Arch Ophthalmol. 1994 May; 112(5):683-4. PMID: 8185527.
      Citations: 1     Fields:    Translation:Humans
    48. Wu HZ, Li JZ. [Development of the high effective thrombolytic agents with molecular biological technique]. Zhonghua Nei Ke Za Zhi. 1993 Jan; 32(1):11-3. PMID: 8404311.
      Citations:    Fields:    Translation:Animals
    49. Khawly JA, Saloupis P, Hatchell DL, Machemer R. Daunorubicin treatment in a refined experimental model of proliferative vitreoretinopathy. Graefes Arch Clin Exp Ophthalmol. 1991; 229(5):464-7. PMID: 1937080.
      Citations: 16     Fields:    Translation:AnimalsCells
    50. Wilson CA, Khawly JA, Hatchell DL, Machemer R. Experimental traction retinal detachment in the cat. Graefes Arch Clin Exp Ophthalmol. 1991; 229(6):568-73. PMID: 1765300.
      Citations: 1     Fields:    Translation:AnimalsCells
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