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HAMED JAFAR-NEJAD

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Human Genetics
DivisionMolecular & Human Genetics
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    R01GM084135     (JAFAR-NEJAD, HAMED)Apr 1, 2008 - Feb 29, 2012
    NIH/NIGMS
    Fine-Tuning the Notch Signaling Pathway via O-Glucosylation
    Role: Principal Investigator

    R01DK109982     (JAFAR-NEJAD, HAMED)Jul 15, 2016 - Jun 30, 2020
    NIH/NIDDK
    Negative regulation of Jagged1 by glycosylation: towards a mechanism-based therapy for Alagille syndrome
    Role: Principal Investigator

    R35GM130317     (JAFAR-NEJAD, HAMED)Feb 1, 2019 - Jan 31, 2024
    NIH/NIGMS
    Regulation of developmental signaling pathways by glycosylation and deglycosylation
    Role: Principal Investigator

    R01AR076770     (JAFAR-NEJAD, HAMED)Jul 8, 2020 - Jun 30, 2025
    NIH/NIAMS
    REGULATION OF SKELETAL MUSCLE DEVELOPMENT AND MAINTENANCE BY PROTEIN O-GLUCOSYLTRANSFERASE 1 (POGLUT1)
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Galeone A, Adams JM, Matsuda S, Presa MF, Pandey A, Han SY, Tachida Y, Hirayama H, Vaccari T, Suzuki T, Lutz CM, Affolter M, Zuberi A, Jafar-Nejad H. Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylation. Elife. 2020 Jul 28; 9. PMID: 32720893.
      View in: PubMed
    2. Pandey A, Niknejad N, Jafar-Nejad H. Multifaceted regulation of Notch signaling by glycosylation. Glycobiology. 2020 May 29. PMID: 32472127.
      View in: PubMed
    3. Adams JM, Huppert KA, Castro EC, Lopez MF, Niknejad N, Subramanian S, Zarrin-Khameh N, Finegold MJ, Huppert SS, Jafar-Nejad H. Sox9 Is a Modifier of the Liver Disease Severity in a Mouse Model of Alagille Syndrome. Hepatology. 2020 Apr; 71(4):1331-1349. PMID: 31469182.
      View in: PubMed
    4. Servián-Morilla E, Cabrera-Serrano M, Johnson K, Pandey A, Ito A, Rivas E, Chamova T, Muelas N, Mongini T, Nafissi S, Claeys KG, Grewal RP, Takeuchi M, Hao H, Bönnemann C, Lopes Abath Neto O, Medne L, Brandsema J, Töpf A, Taneva A, Vilchez JJ, Tournev I, Haltiwanger RS, Takeuchi H, Jafar-Nejad H, Straub V, Paradas C. POGLUT1 biallelic mutations cause myopathy with reduced satellite cells, a-dystroglycan hypoglycosylation and a distinctive radiological pattern. Acta Neuropathol. 2020 03; 139(3):565-582. PMID: 31897643.
      View in: PubMed
    5. Pandey A, Harvey BM, Lopez MF, Ito A, Haltiwanger RS, Jafar-Nejad H. Glycosylation of Specific Notch EGF Repeats by O-Fut1 and Fringe Regulates Notch Signaling in Drosophila. Cell Rep. 2019 11 12; 29(7):2054-2066.e6. PMID: 31722217.
      View in: PubMed
    6. Adams JM, Jafar-Nejad H. The Roles of Notch Signaling in Liver Development and Disease. Biomolecules. 2019 10 14; 9(10). PMID: 31615106.
      View in: PubMed
    7. Adams JM, Jafar-Nejad H. Determining Bile Duct Density in the Mouse Liver. J Vis Exp. 2019 04 30; (146). PMID: 31107443.
      View in: PubMed
    8. Niknejad N, Jafar-Nejad H. Unbiased glycomics: a powerful tool in rare disease diagnosis and research. Transl Res. 2019 04; 206:1-4. PMID: 30528322.
      View in: PubMed
    9. Pandey A, Li-Kroeger D, Sethi MK, Lee TV, Buettner FF, Bakker H, Jafar-Nejad H. Sensitized genetic backgrounds reveal differential roles for EGF repeat xylosyltransferases in Drosophila Notch signaling. Glycobiology. 2018 11 01; 28(11):849-859. PMID: 30169771.
      View in: PubMed
    10. Adams JM, Jafar-Nejad H. A New Model of Alagille Syndrome With Broad Phenotypic Representation. Gastroenterology. 2018 03; 154(4):803-806. PMID: 29425927.
      View in: PubMed
    11. Pandey A, Jafar-Nejad H. Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands. J Vis Exp. 2018 01 02; (131). PMID: 29364239.
      View in: PubMed
    12. Wu J, Hunt SD, Matthias N, Servián-Morilla E, Lo J, Jafar-Nejad H, Paradas C, Darabi R. Generation of an induced pluripotent stem cell line (CSCRMi001-A) from a patient with a new type of limb-girdle muscular dystrophy (LGMD) due to a missense mutation in POGLUT1 (Rumi). Stem Cell Res. 2017 10; 24:102-105. PMID: 29034878.
      View in: PubMed
    13. Galeone A, Han SY, Huang C, Hosomi A, Suzuki T, Jafar-Nejad H. Tissue-specific regulation of BMP signaling by Drosophila N-glycanase 1. Elife. 2017 08 04; 6. PMID: 28826503.
      View in: PubMed
    14. Lee TV, Pandey A, Jafar-Nejad H. Xylosylation of the Notch receptor preserves the balance between its activation by trans-Delta and inhibition by cis-ligands in Drosophila. PLoS Genet. 2017 04; 13(4):e1006723. PMID: 28394891.
      View in: PubMed
    15. Servián-Morilla E, Takeuchi H, Lee TV, Clarimon J, Mavillard F, Area-Gómez E, Rivas E, Nieto-González JL, Rivero MC, Cabrera-Serrano M, Gómez-Sánchez L, Martínez-López JA, Estrada B, Márquez C, Morgado Y, Suárez-Calvet X, Pita G, Bigot A, Gallardo E, Fernández-Chacón R, Hirano M, Haltiwanger RS, Jafar-Nejad H, Paradas C. A POGLUT1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss. EMBO Mol Med. 2016 11; 8(11):1289-1309. PMID: 27807076.
      View in: PubMed
    16. Harvey BM, Rana NA, Moss H, Leonardi J, Jafar-Nejad H, Haltiwanger RS. Mapping Sites of O-Glycosylation and Fringe Elongation on Drosophila Notch. J Biol Chem. 2016 07 29; 291(31):16348-60. PMID: 27268051.
      View in: PubMed
    17. Thakurdas SM, Lopez MF, Kakuda S, Fernandez-Valdivia R, Zarrin-Khameh N, Haltiwanger RS, Jafar-Nejad H. Jagged1 heterozygosity in mice results in a congenital cholangiopathy which is reversed by concomitant deletion of one copy of Poglut1 (Rumi). Hepatology. 2016 Feb; 63(2):550-65. PMID: 26235536.
      View in: PubMed
    18. Haltom AR, Jafar-Nejad H. The multiple roles of epidermal growth factor repeat O-glycans in animal development. Glycobiology. 2015 Oct; 25(10):1027-42. PMID: 26175457.
      View in: PubMed
    19. He P, Grotzke JE, Ng BG, Gunel M, Jafar-Nejad H, Cresswell P, Enns GM, Freeze HH. A congenital disorder of deglycosylation: Biochemical characterization of N-glycanase 1 deficiency in patient fibroblasts. Glycobiology. 2015 Aug; 25(8):836-44. PMID: 25900930.
      View in: PubMed
    20. Haltom AR, Lee TV, Harvey BM, Leonardi J, Chen YJ, Hong Y, Haltiwanger RS, Jafar-Nejad H. The protein O-glucosyltransferase Rumi modifies eyes shut to promote rhabdomere separation in Drosophila. PLoS Genet. 2014 Nov; 10(11):e1004795. PMID: 25412384.
      View in: PubMed
    21. LeBon L, Lee TV, Sprinzak D, Jafar-Nejad H, Elowitz MB. Correction: Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states. Elife. 2014; 3. PMID: 25296180.
      View in: PubMed
    22. LeBon L, Lee TV, Sprinzak D, Jafar-Nejad H, Elowitz MB. Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states. Elife. 2014 Sep 25; 3:e02950. PMID: 25255098.
      View in: PubMed
    23. Leonardi J, Jafar-Nejad H. Structure-function analysis of Drosophila Notch using genomic rescue transgenes. Methods Mol Biol. 2014; 1187:29-46. PMID: 25053479.
      View in: PubMed
    24. Lee TV, Sethi MK, Leonardi J, Rana NA, Buettner FF, Haltiwanger RS, Bakker H, Jafar-Nejad H. Negative regulation of notch signaling by xylose. PLoS Genet. 2013 Jun; 9(6):e1003547. PMID: 23754965.
      View in: PubMed
    25. Takeuchi H, Fernández-Valdivia RC, Caswell DS, Nita-Lazar A, Rana NA, Garner TP, Weldeghiorghis TK, Macnaughtan MA, Jafar-Nejad H, Haltiwanger RS. Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase. Proc Natl Acad Sci U S A. 2011 Oct 04; 108(40):16600-5. PMID: 21949356.
      View in: PubMed
    26. Leonardi J, Fernandez-Valdivia R, Li YD, Simcox AA, Jafar-Nejad H. Multiple O-glucosylation sites on Notch function as a buffer against temperature-dependent loss of signaling. Development. 2011 Aug; 138(16):3569-78. PMID: 21771811.
      View in: PubMed
    27. Fernandez-Valdivia R, Takeuchi H, Samarghandi A, Lopez M, Leonardi J, Haltiwanger RS, Jafar-Nejad H. Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi. Development. 2011 May; 138(10):1925-34. PMID: 21490058.
      View in: PubMed
    28. Jafar-Nejad H, Leonardi J, Fernandez-Valdivia R. Role of glycans and glycosyltransferases in the regulation of Notch signaling. Glycobiology. 2010 Aug; 20(8):931-49. PMID: 20368670.
      View in: PubMed
    29. Lee TV, Takeuchi H, Jafar-Nejad H. Regulation of notch signaling via O-glucosylation insights from Drosophila studies. Methods Enzymol. 2010; 480:375-98. PMID: 20816218.
      View in: PubMed
    30. Simcox AA, Austin CL, Jacobsen TL, Jafar-Nejad H. Drosophila embryonic 'fibroblasts': extending mutant analysis in vitro. Fly (Austin). 2008 Nov-Dec; 2(6):306-9. PMID: 19077546.
      View in: PubMed
    31. Lim J, Jafar-Nejad H, Hsu YC, Choi KW. Novel function of the class I bHLH protein Daughterless in the negative regulation of proneural gene expression in the Drosophila eye. EMBO Rep. 2008 Nov; 9(11):1128-33. PMID: 18758436.
      View in: PubMed
    32. Acar M, Jafar-Nejad H, Takeuchi H, Rajan A, Ibrani D, Rana NA, Pan H, Haltiwanger RS, Bellen HJ. Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling. Cell. 2008 Jan 25; 132(2):247-58. PMID: 18243100.
      View in: PubMed
    33. Rogaeva A, Ou XM, Jafar-Nejad H, Lemonde S, Albert PR. Differential repression by freud-1/CC2D1A at a polymorphic site in the dopamine-D2 receptor gene. J Biol Chem. 2007 Jul 20; 282(29):20897-905. PMID: 17535813.
      View in: PubMed
    34. Acar M, Jafar-Nejad H, Giagtzoglou N, Yallampalli S, David G, He Y, Delidakis C, Bellen HJ. Senseless physically interacts with proneural proteins and functions as a transcriptional co-activator. Development. 2006 May; 133(10):1979-89. PMID: 16624856.
      View in: PubMed
    35. Jafar-Nejad H, Tien AC, Acar M, Bellen HJ. Senseless and Daughterless confer neuronal identity to epithelial cells in the Drosophila wing margin. Development. 2006 May; 133(9):1683-92. PMID: 16554363.
      View in: PubMed
    36. Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C, Jafar-Nejad H, Halder G. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol. 2006 Jan; 8(1):27-36. PMID: 16341207.
      View in: PubMed
    37. Jafar-Nejad H, Andrews HK, Acar M, Bayat V, Wirtz-Peitz F, Mehta SQ, Knoblich JA, Bellen HJ. Sec15, a component of the exocyst, promotes notch signaling during the asymmetric division of Drosophila sensory organ precursors. Dev Cell. 2005 Sep; 9(3):351-63. PMID: 16137928.
      View in: PubMed
    38. Tsuda H, Jafar-Nejad H, Patel AJ, Sun Y, Chen HK, Rose MF, Venken KJ, Botas J, Orr HT, Bellen HJ, Zoghbi HY. The AXH domain of Ataxin-1 mediates neurodegeneration through its interaction with Gfi-1/Senseless proteins. Cell. 2005 Aug 26; 122(4):633-44. PMID: 16122429.
      View in: PubMed
    39. Jafar-Nejad H, Bellen HJ. Gfi/Pag-3/senseless zinc finger proteins: a unifying theme? Mol Cell Biol. 2004 Oct; 24(20):8803-12. PMID: 15456856.
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    40. Quan XJ, Denayer T, Yan J, Jafar-Nejad H, Philippi A, Lichtarge O, Vleminckx K, Hassan BA. Evolution of neural precursor selection: functional divergence of proneural proteins. Development. 2004 Apr; 131(8):1679-89. PMID: 15084454.
      View in: PubMed
    41. Jafar-Nejad H, Acar M, Nolo R, Lacin H, Pan H, Parkhurst SM, Bellen HJ. Senseless acts as a binary switch during sensory organ precursor selection. Genes Dev. 2003 Dec 01; 17(23):2966-78. PMID: 14665671.
      View in: PubMed
    42. Zhai RG, Hiesinger PR, Koh TW, Verstreken P, Schulze KL, Cao Y, Jafar-Nejad H, Norga KK, Pan H, Bayat V, Greenbaum MP, Bellen HJ. Mapping Drosophila mutations with molecularly defined P element insertions. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10860-5. PMID: 12960394.
      View in: PubMed
    43. Ou XM, Lemonde S, Jafar-Nejad H, Bown CD, Goto A, Rogaeva A, Albert PR. Freud-1: A neuronal calcium-regulated repressor of the 5-HT1A receptor gene. J Neurosci. 2003 Aug 13; 23(19):7415-25. PMID: 12917378.
      View in: PubMed
    44. Jafar-Nejad H, Norga K, Bellen H. Numb: "Adapting" notch for endocytosis. Dev Cell. 2002 Aug; 3(2):155-6. PMID: 12194846.
      View in: PubMed
    45. Ou XM, Jafar-Nejad H, Storring JM, Meng JH, Lemonde S, Albert PR. Novel dual repressor elements for neuronal cell-specific transcription of the rat 5-HT1A receptor gene. J Biol Chem. 2000 Mar 17; 275(11):8161-8. PMID: 10713139.
      View in: PubMed
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