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GRETCHEN J DARLINGTON

TitleDistinguished Emeritus Professor
InstitutionBaylor College of Medicine
DepartmentHuffington Center on Aging
DivisionHuffington Ctr on Aging
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    Other Positions
    TitleDistinguished Emeritus Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pathology & Immunology
    DivisionPathology

    TitleDistinguished Emeritus Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

    TitleDistinguished Emeritus Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Human Genetics
    DivisionMolecular & Human Genetics

    TitleDistinguished Emeritus Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pediatrics
    DivisionPediatrics-Administration


    Collapse ORNG Applications 
    Collapse Verify Publications

    Collapse Research 
    Collapse research activities and funding
    R01GM032111     (DARLINGTON, GRETCHEN J.)Sep 1, 1982 - Feb 28, 1993
    NIH/NIGMS
    ACTIVATION AND REGULATION OF HEPATIC GENES
    Role: Principal Investigator

    R13HD026431     (DARLINGTON, GRETCHEN J.)Jun 19, 1989 - May 30, 1990
    NIH/NICHD
    FASEB RESEARCH CONFERENCE--CELLULAR &MOLECULAR GENETICS
    Role: Principal Investigator

    T32AG000183     (DONEHOWER, LAWRENCE A.)Sep 14, 1989 - Apr 30, 2015
    NIH/NIA
    Biology of Aging Training Grant
    Role: Co-Principal Investigator

    T32GM008307     (SHAULSKY, GAD)Jul 1, 1990 - Jun 30, 2021
    NIH/NIGMS
    Program in Human and Molecular Genetics
    Role: Co-Principal Investigator

    T32HG000003     (CHINAULT, ALAN CRAIG)Sep 30, 1990 - Jul 31, 1996
    NIH/NHGRI
    GENOMIC ANALYSIS
    Role: Co-Principal Investigator

    R01DK045285     (DARLINGTON, GRETCHEN J.)May 1, 1993 - Apr 30, 2002
    NIH/NIDDK
    C/EBP ALPHA REGULATION OF ADIPOSE TISSUE DIFFERENTIATION
    Role: Principal Investigator

    R13AG011559     (DARLINGTON, GRETCHEN J.)Jun 8, 1993 - Sep 30, 1993
    NIH/NIA
    SYMPOSIUM+SID--CELL CYCLE, CELL AGING, GROWTH REGULATION
    Role: Principal Investigator

    R13AG012379     (DARLINGTON, GRETCHEN J.)Aug 20, 1994 - Jul 31, 1995
    NIH/NIA
    REGULATION OF CELL AND TISSUE DIFFERENTIATION
    Role: Principal Investigator

    R01DK053045     (DARLINGTON, GRETCHEN J.)Aug 28, 1997 - Jul 31, 2006
    NIH/NIDDK
    C/EBP ALPHA REGULATION OF ACUTE PHASE RESPONSE IN VIVO
    Role: Principal Investigator

    R03AG017705     (DARLINGTON, GRETCHEN J.)Sep 30, 1999 - Aug 31, 2001
    NIH/NIA
    METABOLIC SIMILARITIES IN LONG LIVED MODELS
    Role: Principal Investigator

    U24DK058862     (DARLINGTON, GRETCHEN J.)Jun 25, 2001 - May 31, 2005
    NIH/NIDDK
    NIDDK/Baylor Biotech Center
    Role: Principal Investigator

    U01DK063588     (DARLINGTON, GRETCHEN J.)Sep 30, 2002 - Jul 31, 2006
    NIH/NIDDK
    Gene Expression and Discovery in Liver and Gut Stem Cel*
    Role: Principal Investigator

    R13DK076529     (DARLINGTON, GRETCHEN J.)Jul 22, 2006 - Jul 22, 2007
    NIH/NIDDK
    Liver Biology /Development /Disease FASEB Conference
    Role: Principal Investigator

    R01AG028865     (DARLINGTON, GRETCHEN J.)Aug 1, 2007 - Jul 31, 2013
    NIH/NIA
    Molecular Mechanisms of Longevity in Long-Lived Mice
    Role: Principal Investigator

    RC2AG036562     (DARLINGTON, GRETCHEN J.)Sep 30, 2009 - Aug 31, 2012
    NIH/NIA
    Epigenetic Changes with Age in Hematopoietic Stem Cells
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Passman AM, Low J, London R, Tirnitz-Parker JE, Miyajima A, Tanaka M, Strick-Marchand H, Darlington GJ, Finch-Edmondson M, Ochsner S, Zhu C, Whelan J, Callus BA, Yeoh GC. A Transcriptomic Signature of Mouse Liver Progenitor Cells. Stem Cells Int. 2016; 2016:5702873. PMID: 27777588.
      View in: PubMed
    2. Luo M, Jeong M, Sun D, Park HJ, Rodriguez BA, Xia Z, Yang L, Zhang X, Sheng K, Darlington GJ, Li W, Goodell MA. Long non-coding RNAs control hematopoietic stem cell function. Cell Stem Cell. 2015 Apr 02; 16(4):426-38. PMID: 25772072.
      View in: PubMed
    3. Challen GA, Sun D, Mayle A, Jeong M, Luo M, Rodriguez B, Mallaney C, Celik H, Yang L, Xia Z, Cullen S, Berg J, Zheng Y, Darlington GJ, Li W, Goodell MA. Dnmt3a and Dnmt3b have overlapping and distinct functions in hematopoietic stem cells. Cell Stem Cell. 2014 Sep 04; 15(3):350-364. PMID: 25130491.
      View in: PubMed
    4. Sun D, Luo M, Jeong M, Rodriguez B, Xia Z, Hannah R, Wang H, Le T, Faull KF, Chen R, Gu H, Bock C, Meissner A, Göttgens B, Darlington GJ, Li W, Goodell MA. Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal. Cell Stem Cell. 2014 May 01; 14(5):673-88. PMID: 24792119.
      View in: PubMed
    5. McClellan AJ, Volpe EA, Zhang X, Darlington GJ, Li DQ, Pflugfelder SC, de Paiva CS. Ocular surface disease and dacryoadenitis in aging C57BL/6 mice. Am J Pathol. 2014 Mar; 184(3):631-43. PMID: 24389165.
      View in: PubMed
    6. Jeong M, Sun D, Luo M, Huang Y, Challen GA, Rodriguez B, Zhang X, Chavez L, Wang H, Hannah R, Kim SB, Yang L, Ko M, Chen R, Göttgens B, Lee JS, Gunaratne P, Godley LA, Darlington GJ, Rao A, Li W, Goodell MA. Large conserved domains of low DNA methylation maintained by Dnmt3a. Nat Genet. 2014 Jan; 46(1):17-23. PMID: 24270360.
      View in: PubMed
    7. Jiang Y, Jin J, Iakova P, Hernandez JC, Jawanmardi N, Sullivan E, Guo GL, Timchenko NA, Darlington GJ. Farnesoid X receptor directly regulates xenobiotic detoxification genes in the long-lived Little mice. Mech Ageing Dev. 2013 Sep; 134(9):407-15. PMID: 24007921.
      View in: PubMed
    8. Reddy AK, Hartley CJ, Pham TT, Darlington G, Entman ML, Taffet GE. Young little mice express a premature cardiovascular aging phenotype. J Gerontol A Biol Sci Med Sci. 2014 Feb; 69(2):152-9. PMID: 23682160.
      View in: PubMed
    9. Jiang Y, Iakova P, Jin J, Sullivan E, Sharin V, Hong IH, Anakk S, Mayor A, Darlington G, Finegold M, Moore D, Timchenko NA. Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer. Hepatology. 2013 Mar; 57(3):1098-106. PMID: 23172628.
      View in: PubMed
    10. Lee JS, Ward WO, Ren H, Vallanat B, Darlington GJ, Han ES, Laguna JC, DeFord JH, Papaconstantinou J, Selman C, Corton JC. Meta-analysis of gene expression in the mouse liver reveals biomarkers associated with inflammation increased early during aging. Mech Ageing Dev. 2012 Jul; 133(7):467-78. PMID: 22704917.
      View in: PubMed
    11. Challen GA, Sun D, Jeong M, Luo M, Jelinek J, Berg JS, Bock C, Vasanthakumar A, Gu H, Xi Y, Liang S, Lu Y, Darlington GJ, Meissner A, Issa JP, Godley LA, Li W, Goodell MA. Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet. 2011 Dec 04; 44(1):23-31. PMID: 22138693.
      View in: PubMed
    12. Qiu Q, Hernandez JC, Dean AM, Rao PH, Darlington GJ. CD24-positive cells from normal adult mouse liver are hepatocyte progenitor cells. Stem Cells Dev. 2011 Dec; 20(12):2177-88. PMID: 21361791.
      View in: PubMed
    13. Singh P, Goode T, Dean A, Awad SS, Darlington GJ. Elevated interferon gamma signaling contributes to impaired regeneration in the aged liver. J Gerontol A Biol Sci Med Sci. 2011 Sep; 66(9):944-56. PMID: 21719609.
      View in: PubMed
    14. Kurinna S, Stratton SA, Tsai WW, Akdemir KC, Gu W, Singh P, Goode T, Darlington GJ, Barton MC. Direct activation of forkhead box O3 by tumor suppressors p53 and p73 is disrupted during liver regeneration in mice. Hepatology. 2010 Sep; 52(3):1023-32. PMID: 20564353.
      View in: PubMed
    15. Jin J, Wang GL, Shi X, Darlington GJ, Timchenko NA. The age-associated decline of glycogen synthase kinase 3beta plays a critical role in the inhibition of liver regeneration. Mol Cell Biol. 2009 Jul; 29(14):3867-80. PMID: 19398579.
      View in: PubMed
    16. El-Serag HB, Nurgalieva ZZ, Mistretta TA, Finegold MJ, Souza R, Hilsenbeck S, Shaw C, Darlington G. Gene expression in Barrett's esophagus: laser capture versus whole tissue. Scand J Gastroenterol. 2009; 44(7):787-95. PMID: 19391063.
      View in: PubMed
    17. Darlington GJ. Inoculation and passaging of Mammalian monolayer cell cultures. CSH Protoc. 2008 Aug 01; 2008:pdb.prot4347. PMID: 21356879.
      View in: PubMed
    18. Singh P, Coskun ZZ, Goode C, Dean A, Thompson-Snipes L, Darlington G. Lymphoid neogenesis and immune infiltration in aged liver. Hepatology. 2008 May; 47(5):1680-90. PMID: 18395842.
      View in: PubMed
    19. Reddy AK, Amador-Noguez D, Darlington GJ, Scholz BA, Michael LH, Hartley CJ, Entman ML, Taffet GE. Cardiac function in young and old Little mice. J Gerontol A Biol Sci Med Sci. 2007 Dec; 62(12):1319-25. PMID: 18166681.
      View in: PubMed
    20. Ochsner SA, Strick-Marchand H, Qiu Q, Venable S, Dean A, Wilde M, Weiss MC, Darlington GJ. Transcriptional profiling of bipotential embryonic liver cells to identify liver progenitor cell surface markers. Stem Cells. 2007 Oct; 25(10):2476-87. PMID: 17641245.
      View in: PubMed
    21. Darlington GJ. Inoculation and passaging of Mammalian cell suspension cultures. CSH Protoc. 2007 Jun 01; 2007:pdb.prot4346. PMID: 21357091.
      View in: PubMed
    22. Darlington GJ. Viability staining of Mammalian cell cultures. CSH Protoc. 2007 Jun 01; 2007:pdb.prot4769. PMID: 21357107.
      View in: PubMed
    23. Amador-Noguez D, Dean A, Huang W, Setchell K, Moore D, Darlington G. Alterations in xenobiotic metabolism in the long-lived Little mice. Aging Cell. 2007 Aug; 6(4):453-70. PMID: 17521389.
      View in: PubMed
    24. Darlington GJ. Epstein-barr virus transformation of lymphoblasts. CSH Protoc. 2006 Jul 01; 2006(2). PMID: 22485828.
      View in: PubMed
    25. El-Serag HB, Nurgalieva Z, Souza RF, Shaw C, Darlington G. Is genomic evaluation feasible in endoscopic studies of Barrett's esophagus? A pilot study. Gastrointest Endosc. 2006 Jul; 64(1):17-26. PMID: 16813797.
      View in: PubMed
    26. Darlington GJ. Lymphocyte isolation and culture. CSH Protoc. 2006 Jul 01; 2006(2). PMID: 22485827.
      View in: PubMed
    27. Darlington GJ. Detection of Mycoplasma in Mammalian cell cultures using fluorescence microscopy. CSH Protoc. 2006 Jun 01; 2006(1). PMID: 22485725.
      View in: PubMed
    28. Darlington GJ. Trypsinization of cells grown in monolayer. CSH Protoc. 2006 Jun 01; 2006(1). PMID: 22485723.
      View in: PubMed
    29. Darlington GJ. Serum testing for Mammalian cell culture. CSH Protoc. 2006 Jun 01; 2006(1). PMID: 22485722.
      View in: PubMed
    30. Darlington GJ. Cryopreservation of Mammalian culture cells: preparation and recovery of samples. CSH Protoc. 2006 Jun 01; 2006(1). PMID: 22485724.
      View in: PubMed
    31. Yoshida Y, Hughes DE, Rausa FM, Kim IM, Tan Y, Darlington GJ, Costa RH. C/EBPalpha and HNF6 protein complex formation stimulates HNF6-dependent transcription by CBP coactivator recruitment in HepG2 cells. Hepatology. 2006 Feb; 43(2):276-86. PMID: 16440369.
      View in: PubMed
    32. Bowman TV, McCooey AJ, Merchant AA, Ramos CA, Fonseca P, Poindexter A, Bradfute SB, Oliveira DM, Green R, Zheng Y, Jackson KA, Chambers SM, McKinney-Freeman SL, Norwood KG, Darlington G, Gunaratne PH, Steffen D, Goodell MA. Differential mRNA processing in hematopoietic stem cells. Stem Cells. 2006 Mar; 24(3):662-70. PMID: 16373690.
      View in: PubMed
    33. Yang J, Croniger CM, Lekstrom-Himes J, Zhang P, Fenyus M, Tenen DG, Darlington GJ, Hanson RW. Metabolic response of mice to a postnatal ablation of CCAAT/enhancer-binding protein alpha. J Biol Chem. 2005 Nov 18; 280(46):38689-99. PMID: 16166091.
      View in: PubMed
    34. Abrams SA, Griffin IJ, Hawthorne KM, Liang L, Gunn SK, Darlington G, Ellis KJ. A combination of prebiotic short- and long-chain inulin-type fructans enhances calcium absorption and bone mineralization in young adolescents. Am J Clin Nutr. 2005 Aug; 82(2):471-6. PMID: 16087995.
      View in: PubMed
    35. Amador-Noguez D, Zimmerman J, Venable S, Darlington G. Gender-specific alterations in gene expression and loss of liver sexual dimorphism in the long-lived Ames dwarf mice. Biochem Biophys Res Commun. 2005 Jul 15; 332(4):1086-100. PMID: 15925325.
      View in: PubMed
    36. Abrams SA, Griffin IJ, Hawthorne KM, Chen Z, Gunn SK, Wilde M, Darlington G, Shypailo RJ, Ellis KJ. Vitamin D receptor Fok1 polymorphisms affect calcium absorption, kinetics, and bone mineralization rates during puberty. J Bone Miner Res. 2005 Jun; 20(6):945-53. PMID: 15883634.
      View in: PubMed
    37. Amador-Noguez D, Yagi K, Venable S, Darlington G. Gene expression profile of long-lived Ames dwarf mice and Little mice. Aging Cell. 2004 Dec; 3(6):423-41. PMID: 15569359.
      View in: PubMed
    38. Mackey SL, Darlington GJ. CCAAT enhancer-binding protein alpha is required for interleukin-6 receptor alpha signaling in newborn hepatocytes. J Biol Chem. 2004 Apr 16; 279(16):16206-13. PMID: 14960573.
      View in: PubMed
    39. Mackey S, Singh P, Darlington GJ. Making the liver young again. Hepatology. 2003 Dec; 38(6):1349-52. PMID: 14647042.
      View in: PubMed
    40. Akiba T, Kuroiwa N, Shimizu-Yabe A, Iwase K, Hiwasa T, Yokoe H, Kubosawa H, Kageyama R, Darlington GJ, Mori M, Tanzawa H, Takiguchi M, Dahrington GJ. Expression and regulation of the gene for arginase I in mouse salivary glands: requirement of CCAAT/enhancer-binding protein alpha for the expression in the parotid gland. J Biochem. 2002 Oct; 132(4):621-7. PMID: 12359078.
      View in: PubMed
    41. Welm AL, Timchenko NA, Ono Y, Sorimachi H, Radomska HS, Tenen DG, Lekstrom-Himes J, Darlington GJ. C/EBPalpha is required for proteolytic cleavage of cyclin A by calpain 3 in myeloid precursor cells. J Biol Chem. 2002 Sep 13; 277(37):33848-56. PMID: 12105198.
      View in: PubMed
    42. Carmona MC, Iglesias R, Obregón MJ, Darlington GJ, Villarroya F, Giralt M. Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha. J Biol Chem. 2002 Jun 14; 277(24):21489-98. PMID: 11940593.
      View in: PubMed
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