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GEOFFREY PREIDIS

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Gastroenterology
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    Collapse ORNG Applications 
    Collapse Faculty Mentor
    Collapse Verify Publications

    Collapse Biography 
    Collapse education and training
    Harvard University, Cambridge, MAA.B., cum laude05/2003Physics
    Baylor College of Medicine, Houston, TXPh.D.02/2011Translational Biology and Molecular Medicine
    Baylor College of Medicine, Houston, TXM.D.05/2012
    Baylor College of Medicine, Houston, TXInternship06/2013Pediatrics
    Baylor College of Medicine, Houston, TXResidency06/2014Pediatrics
    Baylor College of Medicine, Houston, TXFellowship06/2018Pediatric Gastroenterology, Hepatology & Nutrition
    Collapse awards and honors
    2017 - 2022Mentored Clinical Scientist Research Career Development Award (K08), National Institute of Diabetes and Digestive and Kidney Diseases
    2017 - 2017Chao Physician-Scientist Award, Ting Tsung and Wei Fong Chao Foundation
    2017 - 2017AGA-Rome Foundation Functional GI and Motility Pilot Award, American Gastroenterological Association / Rome Foundation
    2017 - 2017ANMS Research Grant, American Neurogastroenterology and Motility Society
    2016 - 2017Functional and Mechanistic Award, Akek Center for Metagenomics and Microbial Research
    2016 - 2018The Texas Medical Center Digestive Disease Center Pilot/Feasibility Award, The Texas Medical Digestive Diseases Center
    2015 - 2017NASPGHAN Foundation / Nestle Nutrition Research Young Investigator Development Award, North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition
    2015 - 2017Ruth L. Kirschstein National Research Service Award Institutional Research Training Grant (T32), National Institute of Diabetes and Digestive and Kidney Diseases
    2013 - 2014Thrasher Research Fund Early Career Award, Thrasher Research Fund
    2013 - 2014Young Investigator Grant for Probiotics Research, Global Probiotics Council, Global Probiotics Council
    2009 - 2012Ruth L. Kirschstein National Research Service Award for Individual Predoctoral MD/PhD Fellows (F30), National Institute of Diabetes and Digestive and Kidney Diseases

    Collapse Overview 
    Collapse overview
    Our goal is to define mechanisms through which early life undernutrition alters metabolism and to determine how undernutrition influences intestinal and liver function. Undernutrition causes acute medical problems, but also long term health problems that may result from permanent epigenetic changes that alter transcription or via changes in the gut microbiome. Current studies focus on how malnutrition alters hepatic secretion, transcriptional programming, gastrointestinal motility, and host-microbiome interactions to impact growth. Our work is pertinent to those suffering from nutritional deficiencies caused by a wide range of medical and socioeconomic factors, including preterm and underweight newborns in the neonatal intensive care unit, children with severe acute malnutrition in the developing world, and adolescents with anorexia nervosa.

    Collapse Research 
    Collapse research activities and funding
    F30DK081269     (PREIDIS, GEOFFREY A)Jun 1, 2009 - May 31, 2012
    NIH/NIDDK
    Mechanisms of Immunomodulation by Probiotic L. reuteri in Acute Gastroenteritis
    Role: Principal Investigator

    Private     (PREIDIS, GEOFFREY A)Jul 1, 2013 - Jun 30, 2014
    Young Investigator Grant for Probiotics Research, Global Probiotics Council
    Elucidating the Role of the Intestinal Microbiome in Protein-Energy Undernutrition
    Role Description: This proposal aimed to use metabolomics and metagenomics approaches to determine how bacteria living in the gut contribute to the harmful effects of severe malnutrition, or to the protection of children against food shortages.
    Role: Principal Investigator

    Private     (PREIDIS, GEOFFREY A)Oct 1, 2013 - Sep 30, 2014
    Thrasher Research Fund Early Career Award
    The Intestinal Microbiome as a Biomarker and Therapeutic Target in Severe Acute Malnutrition
    Role Description: This proposal aimed to identify specific gut bacteria and microbial genes associated with malnutrition, and sought to determine whether the disruptions to gut microbial communities due to early starvation persist after refeeding.
    Role: Principal Investigator

    T32DK007664     (SHULMAN, ROBERT J)Jul 1, 2015 - Aug 31, 2017
    NIH/NIDDK
    Mechanisms of Dysregulation of Bile Acid Synthesis in Protein-Energy Undernutrition
    Role Description: The goal of this Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grant was to expand my areas of basic science expertise through a mentored basic science training experience with David D. Moore, Ph.D., international expert in nuclear hormone receptor regulation of bile acid signaling.
    Role: Trainee

    Private     (PREIDIS, GEOFFREY A)Nov 15, 2015 - Nov 14, 2017
    NASPGHAN Foundation/ Nestle Nutrition Research Young Investigator Development Award
    Glycan Metabolism Shapes the Undernourished Intestinal Microbiome and Influences Weight Gain
    Role Description: The goals of this award were to identify mechanisms by which a calorie- and protein-deficient diet alters the composition of intestinal microbes, and to identify the resulting effects on the undernourished intestine and host.
    Role: Principal Investigator

    P30DK56338     (EL-SERAG, HASHEM B & PREIDIS, GEOFFREY A)Feb 1, 2016 - Jan 31, 2018
    NIH/NIDDK
    Persistent Epigenetic Changes in Early Undernutrition
    Role Description: The goal of this Pilot/Feasibility Award supported by the Texas Medical Center Digestive Diseases Center was to elucidate epigenetic mechanisms by which nutritional insults in early life lead to persistent changes in hepatocyte gene expression and development of metabolic diseases later in life.
    Role: Principal Investigator

    Private     (PREIDIS, GEOFFREY A)Nov 1, 2016 - Jun 30, 2017
    The Alkek Center for Metagenomics and Microbiome Research Functional and Mechanistic Award
    Microbial Mechanisms of Pathogenesis Underlying non-Helicobacter Gastritis
    Role Description: The aim of this study was to determine gastric mucosal microbes and microbial virulence factors associated with non-Helicobacter gastritis in children.
    Role: Principal Investigator

    Private     (PREIDIS, GEOFFREY A)Feb 1, 2017 - Jun 30, 2017
    The American Neurogastroenterology and Motility Society Research Grant
    Bile Acids and Intestinal Dysmotility in Early Life Undernutrition
    Role Description: This proposal sought to identify nutrition-sensitive mechanisms that underlie gastrointestinal dysmotility; in particular, the role of altered bile acid receptor signaling was investigated.
    Role: Principal Investigator

    Private     (PREIDIS, GEOFFREY A)Jul 1, 2017 - Aug 31, 2017
    The Ting Tsung and Wei Fong Chao Foundation, Chao Physician-Scientist Award
    Nuclear Receptor Mediated Bile Acid Alterations and Coagulopathy in Protein-Energy Undernutrition
    Role Description: The goal of this award were to understand how the altered ratio of activation between two nuclear receptors, FXR and PPARa, influences the decreased hepatic synthesis of bile acids and coagulation factors, two hallmark features of severe undernutrition; this award provides support for early-career scientists who are actively pursuing NIH K-level funding.
    Role: Principal Investigator

    Private     (PREIDIS, GEOFFREY A)Jul 1, 2017 - Jun 30, 2018
    AGA-Rome Foundation Functional GI and Motility Disorders Pilot Research Award
    Bile Acid Mediated Dysmotility in Protein-Energy Undernutrition
    Role Description: This proposal sought to identify the role of decreased intestinal bile acid receptor signaling in undernutrition-associated gastrointestinal dysmotility.
    Role: Principal Investigator

    K08DK113114     (PREIDIS, GEOFFREY A)Sep 1, 2017 - Aug 31, 2022
    NIH/NIDDK
    Nuclear receptor mediated bile acid alterations and coagulopathy in protein-energy undernutrition
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Morgan RL, Preidis GA, Kashyap PC, Weizman AV, Sadeghirad B, Chang Y, Florez ID, Foroutan F, Shahid S, Zeraatkar D. Probiotics Reduce Mortality and Morbidity in Preterm, Low Birth Weight Infants: a Systematic Review and Network Meta-analysis of Randomized Trials. Gastroenterology. 2020 Jun 24. PMID: 32592699.
      View in: PubMed
    2. Preidis GA, Weizman AV, Kashyap PC, Sadeghirad B, Morgan RL. AGA Technical Review on the Role of Probiotics in the Management of Gastrointestinal Disorders. Gastroenterology. 2020 Jun 09. PMID: 32531292.
      View in: PubMed
    3. Soni KG, Halder T, Conner ME, Preidis GA. Sexual dimorphism in upper gastrointestinal motility is dependent on duration of fast, time of day, age, and strain of mice. Neurogastroenterol Motil. 2019 09; 31(9):e13654. PMID: 31157504.
      View in: PubMed
    4. Ford SL, Lohmann P, Preidis GA, Gordon PS, O'Donnell A, Hagan J, Venkatachalam A, Balderas M, Luna RA, Hair AB. Improved feeding tolerance and growth are linked to increased gut microbial community diversity in very-low-birth-weight infants fed mother's own milk compared with donor breast milk. Am J Clin Nutr. 2019 04 01; 109(4):1088-1097. PMID: 30982856.
      View in: PubMed
    5. Alves da Silva AV, de Castro Oliveira SB, Di Rienzi SC, Brown-Steinke K, Dehan LM, Rood JK, Carreira VS, Le H, Maier EA, Betz KJ, Aihara E, Ley RE, Preidis GA, Shen L, Moore SR. Murine Methyl Donor Deficiency Impairs Early Growth in Association with Dysmorphic Small Intestinal Crypts and Reduced Gut Microbial Community Diversity. Curr Dev Nutr. 2019 Jan; 3(1):nzy070. PMID: 30643852.
      View in: PubMed
    6. Thaxton GE, Melby PC, Manary MJ, Preidis GA. New Insights into the Pathogenesis and Treatment of Malnutrition. Gastroenterol Clin North Am. 2018 12; 47(4):813-827. PMID: 30337034.
      View in: PubMed
    7. Shin A, Preidis GA, Shulman R, Kashyap PC. The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders. Clin Gastroenterol Hepatol. 2019 01; 17(2):256-274. PMID: 30153517.
      View in: PubMed
    8. Preidis GA, Kim KH, Moore DD. Nutrient sensing nuclear receptors PPAR-alpha and FXR control liver energy balance. J Clin Invest. 2017; 127:1193-1201.
    9. Velly H, Britton RA, Preidis GA. Mechanisms of cross-talk between the diet, the intestinal microbiome, and the undernourished host. Gut Microbes. 2017 03 04; 8(2):98-112. PMID: 27918230.
      View in: PubMed
    10. Preidis GA, Luna RA, Hollister EB, Schady D, Gao C, Finegold MJ, Versalovic J, Shulman RJ. The mucosal microbiota in a young child with severe non-Helicobacter gastritis. Therap Adv Gastroenterol. 2016 Sep; 9(5):749-51. PMID: 27582889.
      View in: PubMed
    11. Preidis GA, Ajami NJ, Wong MC, Bessard BC, Conner ME, Petrosino JF. Microbial-Derived Metabolites Reflect an Altered Intestinal Microbiota during Catch-Up Growth in Undernourished Neonatal Mice. J Nutr. 2016 05; 146(5):940-8. PMID: 27052538.
      View in: PubMed
    12. Preidis GA, Chumpitazi BP, Shulman RJ. Pediatric Neurogastroenterology: Gastrointestinal Motility and Functional Disorders in Children. Faure C, Thapar N, Di Lorenzo C, Eds. The microbiome in neurogastroenterology. 2016.
    13. Preidis GA, Luna RA, Hollister EB, Schady D, Gao C, Finegold MJ, Versalovic J, Shulman R. The mucosal microbiota in a young child with severe non-Helicobacter gastritis. Therapeutic Advances in Gastroenterology. 2016.
    14. Preidis GA, Ajami NJ, Wong MC, Bessard BC, Conner ME, Petrosino JF. Composition and function of the undernourished neonatal mouse intestinal microbiome. J Nutr Biochem. 2015 Oct; 26(10):1050-7. PMID: 26070414.
      View in: PubMed
    15. Preidis GA, Hotez PJ. The newest "omics"--metagenomics and metabolomics--enter the battle against the neglected tropical diseases. PLoS Negl Trop Dis. 2015 Feb; 9(2):e0003382. PMID: 25675250.
      View in: PubMed
    16. Ahmed S, Kim MH, Dave AC, Sabelli R, Kanjelo K, Preidis GA, Giordano TP, Chiao E, Hosseinipour M, Kazembe PN, Chimbwandira F, Abrams EJ. Improved identification and enrolment into care of HIV-exposed and -infected infants and children following a community health worker intervention in Lilongwe, Malawi. J Int AIDS Soc. 2015; 18:19305. PMID: 25571857.
      View in: PubMed
    17. LaCourse SM, Chester FM, Preidis G, McCrary LM, Maliwichi M, McCollum ED, Hosseinipour MC. Lay-screeners and use of WHO growth standards increase case finding of hospitalized Malawian children with severe acute malnutrition. J Trop Pediatr. 2015 Feb; 61(1):44-53. PMID: 25477308.
      View in: PubMed
    18. LaCourse SM, Chester FM, Preidis G, McCrary LM, Arscott-Mills T, Maliwichi M, James G, McCollum ED, Hosseinipour MC. Use of Xpert for the diagnosis of pulmonary tuberculosis in severely malnourished hospitalized Malawian children. Pediatr Infect Dis J. 2014 Nov; 33(11):1200-2. PMID: 25361410.
      View in: PubMed
    19. Finocchario-Kessler S, Gautney BJ, Khamadi S, Okoth V, Goggin K, Spinler JK, Mwangi A, Kimanga D, Clark KF, Olungae HD, Preidis GA. If you text them, they will come: using the HIV infant tracking system to improve early infant diagnosis quality and retention in Kenya. AIDS. 2014 Jul; 28 Suppl 3:S313-21. PMID: 24991904.
      View in: PubMed
    20. McCollum ED, Preidis GA, Maliwichi M, Olson D, McCrary LM, Kazembe PN, Horst Cv, Hoffman I, Hosseinipour MC. Clinical versus rapid molecular HIV diagnosis in hospitalized African infants: a randomized controlled trial simulating point-of-care infant testing. J Acquir Immune Defic Syndr. 2014 May 01; 66(1):e23-30. PMID: 24326604.
      View in: PubMed
    21. Perry SH, Swamy P, Preidis GA, Mwanyumba A, Motsa N, Sarero HN. Implementing the Jadelle implant for women living with HIV in a resource-limited setting: concerns for drug interactions leading to unintended pregnancies. AIDS. 2014 Mar 13; 28(5):791-3. PMID: 24401645.
      View in: PubMed
    22. Preidis GA, Keaton MA, Campeau PM, Bessard BC, Conner ME, Hotez PJ. The undernourished neonatal mouse metabolome reveals evidence of liver and biliary dysfunction, inflammation, and oxidative stress. J Nutr. 2014 Mar; 144(3):273-81. PMID: 24381221.
      View in: PubMed
    23. Bjornstad E, Preidis GA, Lufesi N, Olson D, Kamthunzi P, Hosseinipour MC, McCollum ED. Determining the quality of IMCI pneumonia care in Malawian children. Paediatr Int Child Health. 2014 Feb; 34(1):29-36. PMID: 24091151.
      View in: PubMed
    24. Olson D, Davis NL, Milazi R, Lufesi N, Miller WC, Preidis GA, Hosseinipour MC, McCollum ED. Development of a severity of illness scoring system (inpatient triage, assessment and treatment) for resource-constrained hospitals in developing countries. Trop Med Int Health. 2013 Jul; 18(7):871-8. PMID: 23758198.
      View in: PubMed
    25. Kim MH, Ahmed S, Preidis GA, Abrams EJ, Hosseinipour MC, Giordano TP, Chiao EY, Paul ME, Bhalakia A, Nanthuru D, Kazembe PN. Low rates of mother-to-child HIV transmission in a routine programmatic setting in Lilongwe, Malawi. PLoS One. 2013; 8(5):e64979. PMID: 23741437.
      View in: PubMed
    26. McCollum ED, Bjornstad E, Preidis GA, Hosseinipour MC, Lufesi N. Multicenter study of hypoxemia prevalence and quality of oxygen treatment for hospitalized Malawian children. Trans R Soc Trop Med Hyg. 2013 May; 107(5):285-92. PMID: 23584373.
      View in: PubMed
    27. Preidis GA, McCollum ED, Kamiyango W, Garbino A, Hosseinipour MC, Kazembe PN, Schutze GE, Kline MW. Routine inpatient provider-initiated HIV testing in Malawi, compared with client-initiated community-based testing, identifies younger children at higher risk of early mortality. J Acquir Immune Defic Syndr. 2013 May 01; 63(1):e16-22. PMID: 23364511.
      View in: PubMed
    28. Olson D, Preidis GA, Milazi R, Spinler JK, Lufesi N, Mwansambo C, Hosseinipour MC, McCollum ED. Task shifting an inpatient triage, assessment and treatment programme improves the quality of care for hospitalised Malawian children. Trop Med Int Health. 2013 Jul; 18(7):879-86. PMID: 23600592.
      View in: PubMed
    29. Preidis GA, Saulnier DM, Blutt SE, Mistretta TA, Riehle KP, Major AM, Venable SF, Barrish JP, Finegold MJ, Petrosino JF, Guerrant RL, Conner ME, Versalovic J. Host response to probiotics determined by nutritional status of rotavirus-infected neonatal mice. J Pediatr Gastroenterol Nutr. 2012 Sep; 55(3):299-307. PMID: 22343914.
      View in: PubMed
    30. Kim MH, Ahmed S, Buck WC, Preidis GA, Hosseinipour MC, Bhalakia A, Nanthuru D, Kazembe PN, Chimbwandira F, Giordano TP, Chiao EY, Schutze GE, Kline MW. The Tingathe programme: a pilot intervention using community health workers to create a continuum of care in the prevention of mother to child transmission of HIV (PMTCT) cascade of services in Malawi. J Int AIDS Soc. 2012 Jul 11; 15 Suppl 2:17389. PMID: 22789644.
      View in: PubMed
    31. Preidis GA, Saulnier DM, Blutt SE, Mistretta TA, Riehle KP, Major AM, Venable SF, Finegold MJ, Petrosino JF, Conner ME, Versalovic J. Probiotics stimulate enterocyte migration and microbial diversity in the neonatal mouse intestine. FASEB J. 2012 May; 26(5):1960-9. PMID: 22267340.
      View in: PubMed
    32. McCollum ED, Preidis GA, Golitko CL, Siwande LD, Mwansambo C, Kazembe PN, Hoffman I, Hosseinipour MC, Schutze GE, Kline MW. Routine inpatient human immunodeficiency virus testing system increases access to pediatric human immunodeficiency virus care in sub-Saharan Africa. Pediatr Infect Dis J. 2011 May; 30(5):e75-81. PMID: 21297520.
      View in: PubMed
    33. Preidis GA, McCollum ED, Mwansambo C, Kazembe PN, Schutze GE, Kline MW. Pneumonia and malnutrition are highly predictive of mortality among African children hospitalized with human immunodeficiency virus infection or exposure in the era of antiretroviral therapy. J Pediatr. 2011 Sep; 159(3):484-9. PMID: 21489553.
      View in: PubMed
    34. Thomas CM, Preidis GA, Versalovic J. Mechanisms of immune enhancement by beneficial microbes and probiotics. Old Herborn Univ Semin Monographs. 2011; 24:83-94.
    35. Preidis GA. Mechanisms of probiosis by Lactobacillus reuteri in acute rotaviral gastroenteritis: implications for enteric and diarrheal diseases in the developing world. 2011.
    36. Preidis GA, Hill C, Guerrant RL, Ramakrishna BS, Tannock GW, Versalovic J. Probiotics, enteric and diarrheal diseases, and global health. Gastroenterology. 2011 Jan; 140(1):8-14. PMID: 21075108.
      View in: PubMed
    37. Preidis GA, Shapiro CD, Pierre I, Dyer MJ, Kozinetz CA, Grimes RM. An effective, low-cost approach to implementing HIV/AIDS education programs in low literacy populations: an example from rural Haiti. J Health Care Poor Underserved. 2010 May; 21(2):430-7. PMID: 20453347.
      View in: PubMed
    38. McCollum ED, Preidis GA, Kabue MM, Singogo EB, Mwansambo C, Kazembe PN, Kline MW. Task shifting routine inpatient pediatric HIV testing improves program outcomes in urban Malawi: a retrospective observational study. PLoS One. 2010 Mar 10; 5(3):e9626. PMID: 20224782.
      View in: PubMed
    39. Preidis GA, Versalovic J. Targeting the human microbiome with antibiotics, probiotics, and prebiotics: gastroenterology enters the metagenomics era. Gastroenterology. 2009 May; 136(6):2015-31. PMID: 19462507.
      View in: PubMed
    40. Preidis GA, Wang HC, Lewis DE, Castellanos-Gonzalez A, Rogers KA, Graviss EA, Ward HD, White AC. Seropositive human subjects produce interferon gamma after stimulation with recombinant Cryptosporidium hominis gp15. Am J Trop Med Hyg. 2007 Sep; 77(3):583-5. PMID: 17827383.
      View in: PubMed
    41. Popovich PG, van Rooijen N, Hickey WF, Preidis G, McGaughy V. Hematogenous macrophages express CD8 and distribute to regions of lesion cavitation after spinal cord injury. Exp Neurol. 2003 Aug; 182(2):275-87. PMID: 12895439.
      View in: PubMed
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