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FLORENT ELEFTERIOU

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Human Genetics
DivisionMolecular & Human Genetics
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Orthopedic Surgery
    DivisionOrthopedic Surgery


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    P01CA040035     (ELEFTERIOU, FLORENT)Sep 30, 1985 - Aug 31, 2013
    NIH/NCI
    Effect of Tumors on the Skeleton
    Role: Principal Investigator

    R21DK074994     (ELEFTERIOU, FLORENT)Apr 1, 2006 - Mar 31, 2009
    NIH/NIDDK
    Glucocorticoid-induced bone loss via Beta2-adrenergic signaling in osteoblasts
    Role: Principal Investigator

    R21AR053978     (ELEFTERIOU, FLORENT)Sep 1, 2006 - Aug 31, 2009
    NIH/NIAMS
    NEUROFIBROMIN (Nf1) SIGNALING AND TARGET GENES IN OSTEOBLASTS
    Role: Principal Investigator

    R56AR055966     (ELEFTERIOU, FLORENT)Mar 31, 2008 - Aug 31, 2016
    NIH/NIAMS
    Bone pseudarthrosis: from mouse models to pharmacological therapies
    Role: Principal Investigator

    R01AR055966     (ELEFTERIOU, FLORENT)Jul 1, 2009 - Jun 30, 2014
    NIH/NIAMS
    Bone Pseudoarthrosis Dissected through the Generation of New Mouse Models
    Role: Principal Investigator

    R01DK082471     (ELEFTERIOU, FLORENT)Jul 18, 2009 - May 31, 2014
    NIH/NIDDK
    The Norepinephrine Transporter as a Novel Target for a Bone Anabolic Treatment
    Role: Principal Investigator

    R01CA168717     (ELEFTERIOU, FLORENT)Apr 1, 2013 - Mar 31, 2018
    NIH/NCI
    Role of Sympathetic Activation and RANKL/IL6 in Breast Cancer Bone Metastasis
    Role: Principal Investigator

    R01AG055394     (ELEFTERIOU, FLORENT)Jul 15, 2017 - May 31, 2022
    NIH/NIA
    Senile Osteoporosis as a Neuroskeletal Disease
    Role: Principal Investigator

    R21AR072483     (NYMAN, JEFFRY STEPHEN)Mar 1, 2018 - Feb 29, 2020
    NIH/NIAMS
    Matrix-Sensitive Tools for Detecting NF1-Related Changes in Bone Quality
    Role: Co-Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dengler-Crish CM, Elefteriou F. Shared mechanisms: osteoporosis and Alzheimer's disease? Aging (Albany NY). 2019 Feb 19; 11(5):1317-1318. PMID: 30779704.
      View in: PubMed
    2. Couasnay G, Frey C, Elefteriou F. Promoter Cre-Specific Genotyping Assays for Authentication of Cre-Driver Mouse Lines. JBMR Plus. 2019 Apr; 3(4):e10128. PMID: 31044186.
      View in: PubMed
    3. Zhu Y, Ma Y, Elefteriou F. Cortical bone is an extraneuronal site of norepinephrine uptake in adult mice. Bone Rep. 2018 Dec; 9:188-198. PMID: 30581894.
      View in: PubMed
    4. Couasnay G, Bon N, Devignes CS, Sourice S, Bianchi A, Véziers J, Weiss P, Elefteriou F, Provot S, Guicheux J, Beck-Cormier S, Beck L. PiT1/Slc20a1 Is Required for Endoplasmic Reticulum Homeostasis, Chondrocyte Survival, and Skeletal Development. J Bone Miner Res. 2019 Feb; 34(2):387-398. PMID: 30347511.
      View in: PubMed
    5. Clément-Demange L, Mulcrone PL, Tabarestani TQ, Sterling JA, Elefteriou F. ß2ARs stimulation in osteoblasts promotes breast cancer cell adhesion to bone marrow endothelial cells in an IL-1ß and selectin-dependent manner. J Bone Oncol. 2018 Nov; 13:1-10. PMID: 30245970.
      View in: PubMed
    6. Elefteriou F. Impact of the Autonomic Nervous System on the Skeleton. Physiol Rev. 2018 07 01; 98(3):1083-1112. PMID: 29717928.
      View in: PubMed
    7. Fisher MJ, Belzberg AJ, de Blank P, De Raedt T, Elefteriou F, Ferner RE, Giovannini M, Harris GJ, Kalamarides M, Karajannis MA, Kim A, Lázaro C, Le LQ, Li W, Listernick R, Martin S, Morrison H, Pasmant E, Ratner N, Schorry E, Ullrich NJ, Viskochil D, Weiss B, Widemann BC, Zhu Y, Bakker A, Serra E. 2016 Children's Tumor Foundation conference on neurofibromatosis type 1, neurofibromatosis type 2, and schwannomatosis. Am J Med Genet A. 2018 05; 176(5):1258-1269. PMID: 29681099.
      View in: PubMed
    8. Lee C, Whang YM, Campbell P, Mulcrone PL, Elefteriou F, Cho SW, Park SI. Dual targeting c-met and VEGFR2 in osteoblasts suppresses growth and osteolysis of prostate cancer bone metastasis. Cancer Lett. 2018 02 01; 414:205-213. PMID: 29174801.
      View in: PubMed
    9. Tahaei SE, Couasnay G, Ma Y, Paria N, Gu J, Lemoine BF, Wang X, Rios JJ, Elefteriou F. The reduced osteogenic potential of Nf1-deficient osteoprogenitors is EGFR-independent. Bone. 2018 Jan; 106:103-111. PMID: 29032173.
      View in: PubMed
    10. Mulcrone PL, Campbell JP, Clément-Demange L, Anbinder AL, Merkel AR, Brekken RA, Sterling JA, Elefteriou F. Skeletal Colonization by Breast Cancer Cells Is Stimulated by an Osteoblast and ß2AR-Dependent Neo-Angiogenic Switch. J Bone Miner Res. 2017 Jul; 32(7):1442-1454. PMID: 28300321.
      View in: PubMed
    11. Perry BA, Archer KR, Song Y, Ma Y, Green JK, Elefteriou F, Dahir KM. Erratum to: Medication therapy for attention deficit/hyperactivity disorder is associated with lower risk of fracture: a retrospective cohort study. Osteoporos Int. 2016 07; 27(7):2229. PMID: 26984568.
      View in: PubMed
    12. Stevenson DA, Schill L, Schoyer L, Andresen BS, Bakker A, Bayrak-Toydemir P, Burkitt-Wright E, Chatfield K, Elefteriou F, Elgersma Y, Fisher MJ, Franz D, Gelb BD, Goriely A, Gripp KW, Hardan AY, Keppler-Noreuil KM, Kerr B, Korf B, Leoni C, McCormick F, Plotkin SR, Rauen KA, Reilly K, Roberts A, Sandler A, Siegel D, Walsh K, Widemann BC. The Fourth International Symposium on Genetic Disorders of the Ras/MAPK pathway. Am J Med Genet A. 2016 08; 170(8):1959-66. PMID: 27155140.
      View in: PubMed
    13. Elefteriou F. Role of sympathetic nerves in the establishment of metastatic breast cancer cells in bone. J Bone Oncol. 2016 Sep; 5(3):132-134. PMID: 27761374.
      View in: PubMed
    14. Perry BA, Archer KR, Song Y, Ma Y, Green JK, Elefteriou F, Dahir KM. Medication therapy for attention deficit/hyperactivity disorder is associated with lower risk of fracture: a retrospective cohort study. Osteoporos Int. 2016 07; 27(7):2223-2227. PMID: 26928186.
      View in: PubMed
    15. Lima GM, Corazza BJ, Moraes RM, de Oliveira FE, de Oliveira LD, Franco GC, Perrien DS, Elefteriou F, Anbinder AL. The effect of an inhibitor of gut serotonin (LP533401) during the induction of periodontal disease. J Periodontal Res. 2016 Oct; 51(5):661-8. PMID: 26740292.
      View in: PubMed
    16. Anbinder AL, Moraes RM, Lima GMG, Oliveira FE, Campos DRC, Rossoni RD, Oliveira LD, Junqueira JC, Ma Y, Elefteriou F. Periodontal disease exacerbates systemic ovariectomy-induced bone loss in mice. Bone. 2016 Feb; 83:241-247. PMID: 26620086.
      View in: PubMed
    17. Preston Campbell J, Mulcrone P, Masood SK, Karolak M, Merkel A, Hebron K, Zijlstra A, Sterling J, Elefteriou F. TRIzol and Alu qPCR-based quantification of metastatic seeding within the skeleton. Sci Rep. 2015 Aug 14; 5:12635. PMID: 26271202.
      View in: PubMed
    18. Vignaux G, Besnard S, Denise P, Elefteriou F. The Vestibular System: A Newly Identified Regulator of Bone Homeostasis Acting Through the Sympathetic Nervous System. Curr Osteoporos Rep. 2015 Aug; 13(4):198-205. PMID: 26017583.
      View in: PubMed
    19. Harmata AJ, Ma Y, Sanchez CJ, Zienkiewicz KJ, Elefteriou F, Wenke JC, Guelcher SA. D-amino acid inhibits biofilm but not new bone formation in an ovine model. Clin Orthop Relat Res. 2015 Dec; 473(12):3951-61. PMID: 26201421.
      View in: PubMed
    20. Vignaux G, Ndong JD, Perrien DS, Elefteriou F. Inner Ear Vestibular Signals Regulate Bone Remodeling via the Sympathetic Nervous System. J Bone Miner Res. 2015 Jun; 30(6):1103-11. PMID: 25491117.
      View in: PubMed
    21. Elefteriou F. Chronic stress, sympathetic activation and skeletal metastasis of breast cancer cells. Bonekey Rep. 2015; 4:693. PMID: 25987989.
      View in: PubMed
    22. de la Croix Ndong J, Makowski AJ, Uppuganti S, Vignaux G, Ono K, Perrien DS, Joubert S, Baglio SR, Granchi D, Stevenson DA, Rios JJ, Nyman JS, Elefteriou F. Corrigendum: Asfotase-a improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1. Nat Med. 2015 Apr; 21(4):414. PMID: 25849275.
      View in: PubMed
    23. Karolak MR, Yang X, Elefteriou F. FGFR1 signaling in hypertrophic chondrocytes is attenuated by the Ras-GAP neurofibromin during endochondral bone formation. Hum Mol Genet. 2015 May 01; 24(9):2552-64. PMID: 25616962.
      View in: PubMed
    24. Sant DW, Margraf RL, Stevenson DA, Grossmann AH, Viskochil DH, Hanson H, Everitt MD, Rios JJ, Elefteriou F, Hennessey T, Mao R. Evaluation of somatic mutations in tibial pseudarthrosis samples in neurofibromatosis type 1. J Med Genet. 2015 Apr; 52(4):256-61. PMID: 25612910.
      View in: PubMed
    25. de la Croix Ndong J, Stevens DM, Vignaux G, Uppuganti S, Perrien DS, Yang X, Nyman JS, Harth E, Elefteriou F. Combined MEK inhibition and BMP2 treatment promotes osteoblast differentiation and bone healing in Nf1Osx -/- mice. J Bone Miner Res. 2015 Jan; 30(1):55-63. PMID: 25043591.
      View in: PubMed
    26. de la Croix Ndong J, Makowski AJ, Uppuganti S, Vignaux G, Ono K, Perrien DS, Joubert S, Baglio SR, Granchi D, Stevenson DA, Rios JJ, Nyman JS, Elefteriou F. Asfotase-a improves bone growth, mineralization and strength in mouse models of neurofibromatosis type-1. Nat Med. 2014 Aug; 20(8):904-10. PMID: 24997609.
      View in: PubMed
    27. Kühnisch J, Seto J, Lange C, Stumpp S, Kobus K, Grohmann J, Elefteriou F, Fratzl P, Mundlos S, Kolanczyk M. Neurofibromin inactivation impairs osteocyte development in Nf1Prx1 and Nf1Col1 mouse models. Bone. 2014 Sep; 66:155-62. PMID: 24947449.
      View in: PubMed
    28. Kühnisch J, Seto J, Lange C, Schrof S, Stumpp S, Kobus K, Grohmann J, Kossler N, Varga P, Osswald M, Emmerich D, Tinschert S, Thielemann F, Duda G, Seifert W, El Khassawna T, Stevenson DA, Elefteriou F, Kornak U, Raum K, Fratzl P, Mundlos S, Kolanczyk M. Multiscale, converging defects of macro-porosity, microstructure and matrix mineralization impact long bone fragility in NF1. PLoS One. 2014; 9(1):e86115. PMID: 24465906.
      View in: PubMed
    29. Vignaux G, Besnard S, Ndong J, Philoxène B, Denise P, Elefteriou F. Bone remodeling is regulated by inner ear vestibular signals. J Bone Miner Res. 2013 Oct; 28(10):2136-44. PMID: 23553797.
      View in: PubMed
    30. Ma Y, Krueger JJ, Redmon SN, Uppuganti S, Nyman JS, Hahn MK, Elefteriou F. Extracellular norepinephrine clearance by the norepinephrine transporter is required for skeletal homeostasis. J Biol Chem. 2013 Oct 18; 288(42):30105-13. PMID: 24005671.
      View in: PubMed
    31. Elefteriou F, Campbell P, Ma Y. Control of bone remodeling by the peripheral sympathetic nervous system. Calcif Tissue Int. 2014 Jan; 94(1):140-51. PMID: 23765388.
      View in: PubMed
    32. Ono K, Karolak MR, Ndong Jde L, Wang W, Yang X, Elefteriou F. The ras-GTPase activity of neurofibromin restrains ERK-dependent FGFR signaling during endochondral bone formation. Hum Mol Genet. 2013 Aug 01; 22(15):3048-62. PMID: 23571107.
      View in: PubMed
    33. Edwards JR, Perrien DS, Fleming N, Nyman JS, Ono K, Connelly L, Moore MM, Lwin ST, Yull FE, Mundy GR, Elefteriou F. Silent information regulator (Sir)T1 inhibits NF-?B signaling to maintain normal skeletal remodeling. J Bone Miner Res. 2013 Apr; 28(4):960-9. PMID: 23172686.
      View in: PubMed
    34. Stevenson DA, Little D, Armstrong L, Crawford AH, Eastwood D, Friedman JM, Greggi T, Gutierrez G, Hunter-Schaedle K, Kendler DL, Kolanczyk M, Monsell F, Oetgen M, Richards BS, Schindeler A, Schorry EK, Wilkes D, Viskochil DH, Yang FC, Elefteriou F. Approaches to treating NF1 tibial pseudarthrosis: consensus from the Children's Tumor Foundation NF1 Bone Abnormalities Consortium. J Pediatr Orthop. 2013 Apr-May; 33(3):269-75. PMID: 23482262.
      View in: PubMed
    35. Campbell JP, Merkel AR, Masood-Campbell SK, Elefteriou F, Sterling JA. Models of bone metastasis. J Vis Exp. 2012 Sep 04; (67):e4260. PMID: 22972196.
      View in: PubMed
    36. Campbell JP, Karolak MR, Ma Y, Perrien DS, Masood-Campbell SK, Penner NL, Munoz SA, Zijlstra A, Yang X, Sterling JA, Elefteriou F. Stimulation of host bone marrow stromal cells by sympathetic nerves promotes breast cancer bone metastasis in mice. PLoS Biol. 2012 Jul; 10(7):e1001363. PMID: 22815651.
      View in: PubMed
    37. Wang W, Lian N, Ma Y, Li L, Gallant RC, Elefteriou F, Yang X. Chondrocytic Atf4 regulates osteoblast differentiation and function via Ihh. Development. 2012 Feb; 139(3):601-11. PMID: 22190639.
      View in: PubMed
    38. Elefteriou F, Yang X. Genetic mouse models for bone studies--strengths and limitations. Bone. 2011 Dec; 49(6):1242-54. PMID: 21907838.
      View in: PubMed
    39. Wang W, Nyman JS, Ono K, Stevenson DA, Yang X, Elefteriou F. Mice lacking Nf1 in osteochondroprogenitor cells display skeletal dysplasia similar to patients with neurofibromatosis type I. Hum Mol Genet. 2011 Oct 15; 20(20):3910-24. PMID: 21757497.
      View in: PubMed
    40. Ma Y, Nyman JS, Tao H, Moss HH, Yang X, Elefteriou F. ß2-Adrenergic receptor signaling in osteoblasts contributes to the catabolic effect of glucocorticoids on bone. Endocrinology. 2011 Apr; 152(4):1412-22. PMID: 21266510.
      View in: PubMed
    41. Wang W, Nyman JS, Moss HE, Gutierrez G, Mundy GR, Yang X, Elefteriou F. Local low-dose lovastatin delivery improves the bone-healing defect caused by Nf1 loss of function in osteoblasts. J Bone Miner Res. 2010 Jul; 25(7):1658-67. PMID: 20200958.
      View in: PubMed
    42. Wang W, Lian N, Li L, Moss HE, Wang W, Perrien DS, Elefteriou F, Yang X. Atf4 regulates chondrocyte proliferation and differentiation during endochondral ossification by activating Ihh transcription. Development. 2009 Dec; 136(24):4143-53. PMID: 19906842.
      View in: PubMed
    43. Elefteriou F, Kolanczyk M, Schindeler A, Viskochil DH, Hock JM, Schorry EK, Crawford AH, Friedman JM, Little D, Peltonen J, Carey JC, Feldman D, Yu X, Armstrong L, Birch P, Kendler DL, Mundlos S, Yang FC, Agiostratidou G, Hunter-Schaedle K, Stevenson DA. Skeletal abnormalities in neurofibromatosis type 1: approaches to therapeutic options. Am J Med Genet A. 2009 Oct; 149A(10):2327-38. PMID: 19764036.
      View in: PubMed
    44. Lian N, Wang W, Li L, Elefteriou F, Yang X. Vimentin inhibits ATF4-mediated osteocalcin transcription and osteoblast differentiation. J Biol Chem. 2009 Oct 30; 284(44):30518-25. PMID: 19726676.
      View in: PubMed
    45. Singh MK, Elefteriou F, Karsenty G. Cocaine and amphetamine-regulated transcript may regulate bone remodeling as a circulating molecule. Endocrinology. 2008 Aug; 149(8):3933-41. PMID: 18450969.
      View in: PubMed
    46. Elefteriou F. Regulation of bone remodeling by the central and peripheral nervous system. Arch Biochem Biophys. 2008 May 15; 473(2):231-6. PMID: 18410742.
      View in: PubMed
    47. Patel MS, Elefteriou F. The new field of neuroskeletal biology. Calcif Tissue Int. 2007 May; 80(5):337-47. PMID: 17440766.
      View in: PubMed
    48. Elefteriou F, Benson MD, Sowa H, Starbuck M, Liu X, Ron D, Parada LF, Karsenty G. ATF4 mediation of NF1 functions in osteoblast reveals a nutritional basis for congenital skeletal dysplasiae. Cell Metab. 2006 Dec; 4(6):441-51. PMID: 17141628.
      View in: PubMed
    49. Mundy GR, Elefteriou F. Boning up on ephrin signaling. Cell. 2006 Aug 11; 126(3):441-3. PMID: 16901775.
      View in: PubMed
    50. Elefteriou F. Neuronal signaling and the regulation of bone remodeling. Cell Mol Life Sci. 2005 Oct; 62(19-20):2339-49. PMID: 16132233.
      View in: PubMed
    51. Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G. Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature. 2005 Mar 24; 434(7032):514-20. PMID: 15724149.
      View in: PubMed
    52. Cock TA, Back J, Elefteriou F, Karsenty G, Kastner P, Chan S, Auwerx J. Enhanced bone formation in lipodystrophic PPARgamma(hyp/hyp) mice relocates haematopoiesis to the spleen. EMBO Rep. 2004 Oct; 5(10):1007-12. PMID: 15359271.
      View in: PubMed
    53. Elefteriou F, Karsenty G. [Bone mass regulation by leptin: a hypothalamic control of bone formation]. Pathol Biol (Paris). 2004 Apr; 52(3):148-53. PMID: 15063934.
      View in: PubMed
    54. Elefteriou F, Takeda S, Ebihara K, Magre J, Patano N, Kim CA, Ogawa Y, Liu X, Ware SM, Craigen WJ, Robert JJ, Vinson C, Nakao K, Capeau J, Karsenty G. Serum leptin level is a regulator of bone mass. Proc Natl Acad Sci U S A. 2004 Mar 02; 101(9):3258-63. PMID: 14978271.
      View in: PubMed
    55. Cui Y, Huang L, Elefteriou F, Yang G, Shelton JM, Giles JE, Oz OK, Pourbahrami T, Lu CY, Richardson JA, Karsenty G, Li C. Essential role of STAT3 in body weight and glucose homeostasis. Mol Cell Biol. 2004 Jan; 24(1):258-69. PMID: 14673160.
      View in: PubMed
    56. Elefteriou F, Takeda S, Liu X, Armstrong D, Karsenty G. Monosodium glutamate-sensitive hypothalamic neurons contribute to the control of bone mass. Endocrinology. 2003 Sep; 144(9):3842-7. PMID: 12933656.
      View in: PubMed
    57. Levasseur R, Barrios R, Elefteriou F, Glass DA, Lieberman MW, Karsenty G. Reversible skeletal abnormalities in gamma-glutamyl transpeptidase-deficient mice. Endocrinology. 2003 Jul; 144(7):2761-4. PMID: 12810527.
      View in: PubMed
    58. Takeda S, Elefteriou F, Karsenty G. Common endocrine control of body weight, reproduction, and bone mass. Annu Rev Nutr. 2003; 23:403-11. PMID: 12730321.
      View in: PubMed
    59. Elefteriou F, Ducy P. [Control of body mass by leptin occurs through the sympathetic nervous system]. Med Sci (Paris). 2003 Apr; 19(4):391-3. PMID: 12836204.
      View in: PubMed
    60. Takeda S, Elefteriou F, Levasseur R, Liu X, Zhao L, Parker KL, Armstrong D, Ducy P, Karsenty G. Leptin regulates bone formation via the sympathetic nervous system. Cell. 2002 Nov 01; 111(3):305-17. PMID: 12419242.
      View in: PubMed
    61. Elefteriou F, Exposito JY, Garrone R, Lethias C. Cell adhesion to tenascin-X mapping of cell adhesion sites and identification of integrin receptors. Eur J Biochem. 1999 Aug; 263(3):840-8. PMID: 10469149.
      View in: PubMed
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