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FENG LI

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pathology & Immunology
DivisionPathology
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    R01DK121970     (LI, FENG)Jan 1, 2020 - Dec 31, 2023
    NIH
    Mechanisms of Liver Toxicity of Anit-Depressant Duloxetine
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Li F, Jäger V. Synthesis of proteasome inhibitor 6-deoxy-omuralide and its enantiomer using stereoselective alkylation of substituted proline ester. Org Biomol Chem. 2020 May 29. PMID: 32469026.
      View in: PubMed
    2. Xu Y, Xu Y, Zhu Y, Sun H, Juguilon C, Li F, Fan D, Yin L, Zhang Y. Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis. Mol Ther. 2020 01 08; 28(1):202-216. PMID: 31604677.
      View in: PubMed
    3. Feng D, Lu Y, Kong X, Li F. Immunotherapy of Liver Diseases. J Immunol Res. 2019; 2019:9343505. PMID: 31531375.
      View in: PubMed
    4. Chen K, Baluya D, Tosun M, Li F, Maletic-Savatic M. Imaging Mass Spectrometry: A New Tool to Assess Molecular Underpinnings of Neurodegeneration. Metabolites. 2019 Jul 10; 9(7). PMID: 31295847.
      View in: PubMed
    5. Lu Y, Zhao X-M, Hu Z, Wang L, Li F . LC–MS-Based Metabolomics in the Study of Drug-Induced Liver Injury. Curr Pharmacol Rep. 2019; 5(1):56-67.
    6. Zhu J, Wang P, Li F, Lu J, Shehu AI, Xie W, McMahon D, Ma X. CYP1A1 and 1B1-mediated metabolic pathways of dolutegravir, an HIV integrase inhibitor. Biochem Pharmacol. 2018 12; 158:174-184. PMID: 30342022.
      View in: PubMed
    7. Duan YH, Zeng LM, Li FN, Kong XF, Xu K, Guo QP, Wang WL, Zhang LY. ß-hydroxy-ß-methyl butyrate promotes leucine metabolism and improves muscle fibre composition in growing pigs. J Anim Physiol Anim Nutr (Berl). 2018 Oct; 102(5):1328-1339. PMID: 30009416.
      View in: PubMed
    8. Kim KH, Choi JM, Li F, Arizpe A, Wooton-Kee CR, Anakk S, Jung SY, Finegold MJ, Moore DD. Xenobiotic Nuclear Receptor Signaling Determines Molecular Pathogenesis of Progressive Familial Intrahepatic Cholestasis. Endocrinology. 2018 06 01; 159(6):2435-2446. PMID: 29718219.
      View in: PubMed
    9. Li F, Zhang N, Gorantla S, Gilbertson SR, Pati D. The Metabolism of Separase Inhibitor Sepin-1 in Human, Mouse, and Rat Liver Microsomes. Front Pharmacol. 2018; 9:313. PMID: 29867452.
      View in: PubMed
    10. Zhao N, Cao J, Xu L, Tang Q, Dobrolecki LE, Lv X, Talukdar M, Lu Y, Wang X, Hu DZ, Shi Q, Xiang Y, Wang Y, Liu X, Bu W, Jiang Y, Li M, Gong Y, Sun Z, Ying H, Yuan B, Lin X, Feng XH, Hartig SM, Li F, Shen H, Chen Y, Han L, Zeng Q, Patterson JB, Kaipparettu BA, Putluri N, Sicheri F, Rosen JM, Lewis MT, Chen X. Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. J Clin Invest. 2018 04 02; 128(4):1283-1299. PMID: 29480818.
      View in: PubMed
    11. Peng H, Wang Q, Lou T, Qin J, Jung S, Shetty V, Li F, Wang Y, Feng XH, Mitch WE, Graham BH, Hu Z. Myokine mediated muscle-kidney crosstalk suppresses metabolic reprogramming and fibrosis in damaged kidneys. Nat Commun. 2017 11 14; 8(1):1493. PMID: 29138395.
      View in: PubMed
    12. Barzi M, Pankowicz FP, Zorman B, Liu X, Legras X, Yang D, Borowiak M, Bissig-Choisat B, Sumazin P, Li F, Bissig KD. Erratum: A novel humanized mouse lacking murine p450 oxidoreductase for studying human drug metabolism. Nat Commun. 2017 10 17; 8(1):984. PMID: 29042563.
      View in: PubMed
    13. York B, Li F, Lin F, Marcelo KL, Mao J, Dean A, Gonzales N, Gooden D, Maity S, Coarfa C, Putluri N, Means AR. Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD. Sci Rep. 2017 09 18; 7(1):11793. PMID: 28924233.
      View in: PubMed
    14. Shi X, Chacko S, Li F, Li D, Burrin D, Chan L, Guan X. Acute activation of GLP-1-expressing neurons promotes glucose homeostasis and insulin sensitivity. Mol Metab. 2017 11; 6(11):1350-1359. PMID: 29107283.
      View in: PubMed
    15. Kim ER, Fan S, Akhmedov D, Sun K, Lim H, O'Brien W, Xu Y, Mangieri LR, Zhu Y, Lee CC, Chung Y, Xia Y, Xu Y, Li F, Sun K, Berdeaux R, Tong Q. Red blood cell ß-adrenergic receptors contribute to diet-induced energy expenditure by increasing O2 supply. JCI Insight. 2017 Jul 20; 2(14). PMID: 28724789.
      View in: PubMed
    16. Jiang X, Chen J, Bajic A, Zhang C, Song X, Carroll SL, Cai ZL, Tang M, Xue M, Cheng N, Schaaf CP, Li F, MacKenzie KR, Ferreon ACM, Xia F, Wang MC, Maletic-Savatic M, Wang J. Quantitative real-time imaging of glutathione. Nat Commun. 2017 07 13; 8:16087. PMID: 28703127.
      View in: PubMed
    17. Barzi M, Pankowicz FP, Zorman B, Liu X, Legras X, Yang D, Borowiak M, Bissig-Choisat B, Sumazin P, Li F, Bissig KD. A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism. Nat Commun. 2017 06 28; 8(1):39. PMID: 28659616.
      View in: PubMed
    18. Li F, He Z, Ye Y. Isocartormin, a novel quinochalcone C-glycoside from Carthamus tinctorius. Acta Pharm Sin B. 2017 Jul; 7(4):527-531. PMID: 28752041.
      View in: PubMed
    19. Li J, Wang Y, Matye DJ, Chavan H, Krishnamurthy P, Li F, Li T. Sortilin 1 Modulates Hepatic Cholesterol Lipotoxicity in Mice via Functional Interaction with Liver Carboxylesterase 1. J Biol Chem. 2017 Jan 06; 292(1):146-160. PMID: 27881673.
      View in: PubMed
    20. Cai M, He J, Xiong J, Tay LW, Wang Z, Rog C, Wang J, Xie Y, Wang G, Banno Y, Li F, Zhu M, Du G. Phospholipase D1-regulated autophagy supplies free fatty acids to counter nutrient stress in cancer cells. Cell Death Dis. 2016 11 03; 7(11):e2448. PMID: 27809301.
      View in: PubMed
    21. Marcano DC, Shin CS, Lee B, Isenhart LC, Liu X, Li F, Jester JV, Pflugfelder SC, Simpson J, Acharya G. Synergistic Cysteamine Delivery Nanowafer as an Efficacious Treatment Modality for Corneal Cystinosis. Mol Pharm. 2016 10 03; 13(10):3468-3477. PMID: 27571217.
      View in: PubMed
    22. Li F, Wang P, Liu K, Tarrago MG, Lu J, Chini EN, Ma X. A High Dose of Isoniazid Disturbs Endobiotic Homeostasis in Mouse Liver. Drug Metab Dispos. 2016 11; 44(11):1742-1751. PMID: 27531952.
      View in: PubMed
    23. Sachar M, Li F, Liu K, Wang P, Lu J, Ma X. Chronic Treatment with Isoniazid Causes Protoporphyrin IX Accumulation in Mouse Liver. Chem Res Toxicol. 2016 08 15; 29(8):1293-7. PMID: 27438535.
      View in: PubMed
    24. Donepudi AC, Boehme S, Li F, Chiang JY. G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice. Hepatology. 2017 03; 65(3):813-827. PMID: 27351453.
      View in: PubMed
    25. Ferrell JM, Boehme S, Li F, Chiang JY. Cholesterol 7a-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders. J Lipid Res. 2016 07; 57(7):1144-54. PMID: 27146480.
      View in: PubMed
    26. Liu X, Lu YF, Guan X, Zhao M, Wang J, Li F. Characterizing novel metabolic pathways of melatonin receptor agonist agomelatine using metabolomic approaches. Biochem Pharmacol. 2016 06 01; 109:70-82. PMID: 27021842.
      View in: PubMed
    27. Song X, Zhang C, Zhao M, Chen H, Liu X, Chen J, Lonard DM, Qin L, Xu J, Wang X, Li F, O'Malley BW, Wang J. Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug. PLoS One. 2015; 10(10):e0140011. PMID: 26431029.
      View in: PubMed
    28. Liu X, Lu Y, Guan X, Dong B, Chavan H, Wang J, Zhang Y, Krishnamurthy P, Li F. Metabolomics reveals the formation of aldehydes and iminium in gefitinib metabolism. Biochem Pharmacol. 2015 Sep 01; 97(1):111-21. PMID: 26212543.
      View in: PubMed
    29. Woolbright BL, Dorko K, Antoine DJ, Clarke JI, Gholami P, Li F, Kumer SC, Schmitt TM, Forster J, Fan F, Jenkins RE, Park BK, Hagenbuch B, Olyaee M, Jaeschke H. Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis. Toxicol Appl Pharmacol. 2015 Mar 15; 283(3):168-77. PMID: 25636263.
      View in: PubMed
    30. Chavan H, Li F, Tessman R, Mickey K, Dorko K, Schmitt T, Kumer S, Gunewardena S, Gaikwad N, Krishnamurthy P. Functional coupling of ATP-binding cassette transporter Abcb6 to cytochrome P450 expression and activity in liver. J Biol Chem. 2015 Mar 20; 290(12):7871-86. PMID: 25623066.
      View in: PubMed
    31. Woolbright BL, Li F, Xie Y, Farhood A, Fickert P, Trauner M, Jaeschke H. Lithocholic acid feeding results in direct hepato-toxicity independent of neutrophil function in mice. Toxicol Lett. 2014 Jul 03; 228(1):56-66. PMID: 24742700.
      View in: PubMed
    32. Liu K, Li F, Lu J, Liu S, Dorko K, Xie W, Ma X. Bedaquiline metabolism: enzymes and novel metabolites. Drug Metab Dispos. 2014 May; 42(5):863-6. PMID: 24513655.
      View in: PubMed
    33. Li F, Lu J, Ma X. CPY3A4-mediated a-hydroxyaldehyde formation in saquinavir metabolism. Drug Metab Dispos. 2014 Feb; 42(2):213-20. PMID: 24212380.
      View in: PubMed
    34. Bhushan B, Borude P, Edwards G, Walesky C, Cleveland J, Li F, Ma X, Apte U. Role of bile acids in liver injury and regeneration following acetaminophen overdose. Am J Pathol. 2013 Nov; 183(5):1518-1526. PMID: 24007882.
      View in: PubMed
    35. McGill MR, Li F, Sharpe MR, Williams CD, Curry SC, Ma X, Jaeschke H. Circulating acylcarnitines as biomarkers of mitochondrial dysfunction after acetaminophen overdose in mice and humans. Arch Toxicol. 2014 Feb; 88(2):391-401. PMID: 23979652.
      View in: PubMed
    36. Li F, Lu J, Cheng J, Wang L, Matsubara T, Csanaky IL, Klaassen CD, Gonzalez FJ, Ma X. Human PXR modulates hepatotoxicity associated with rifampicin and isoniazid co-therapy. Nat Med. 2013 Apr; 19(4):418-20. PMID: 23475203.
      View in: PubMed
    37. Borude P, Edwards G, Walesky C, Li F, Ma X, Kong B, Guo GL, Apte U. Hepatocyte-specific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice. Hepatology. 2012 Dec; 56(6):2344-52. PMID: 22730081.
      View in: PubMed
    38. Li F, Lu J, Ma X. Metabolomic screening and identification of the bioactivation pathways of ritonavir. Chem Res Toxicol. 2011 Dec 19; 24(12):2109-14. PMID: 22040299.
      View in: PubMed
    39. Li F, Lu J, Ma X. CYP3A4-mediated lopinavir bioactivation and its inhibition by ritonavir. Drug Metab Dispos. 2012 Jan; 40(1):18-24. PMID: 21953914.
      View in: PubMed
    40. Li F, Miao Y, Zhang L, Neuenswander SA, Douglas JT, Ma X. Metabolomic analysis reveals novel isoniazid metabolites and hydrazones in human urine. Drug Metab Pharmacokinet. 2011; 26(6):569-76. PMID: 21844656.
      View in: PubMed
    41. Li F, Lu J, Ma X. Profiling the reactive metabolites of xenobiotics using metabolomic technologies. Chem Res Toxicol. 2011 May 16; 24(5):744-51. PMID: 21469730.
      View in: PubMed
    42. Li F, Lu J, Wang L, Ma X. CYP3A-mediated generation of aldehyde and hydrazine in atazanavir metabolism. Drug Metab Dispos. 2011 Mar; 39(3):394-401. PMID: 21148252.
      View in: PubMed
    43. Wang L, Li F, Lu J, Li G, Li D, Zhong XB, Guo GL, Ma X. The Chinese herbal medicine Sophora flavescens activates pregnane X receptor. Drug Metab Dispos. 2010 Dec; 38(12):2226-31. PMID: 20736322.
      View in: PubMed
    44. Niu S, Li F, Tan DX, Zhang L, Idle JR, Gonzalez FJ, Ma X. Analysis of N1-acetyl-N2-formyl-5-methoxykynuramine/N1-acetyl-5-methoxy-kynuramine formation from melatonin in mice. J Pineal Res. 2010 Sep; 49(2):106-14. PMID: 20545825.
      View in: PubMed
    45. Li F, Wang L, Guo GL, Ma X. Metabolism-mediated drug interactions associated with ritonavir-boosted tipranavir in mice. Drug Metab Dispos. 2010 May; 38(5):871-8. PMID: 20103582.
      View in: PubMed
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