Loading...
Header Logo
Institute for Clinical and Translational Research

Profiles



Video Tutorials
Keywords
Last Name
Institution

ERIC C CHANG

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology
vCardDownload vCard
    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentBreast Center
    DivisionBreast Cancer Center


    Collapse ORNG Applications 
    Collapse Verify Publications

    Collapse Research 
    Collapse research activities and funding
    R01CA090464     (CHANG, ERIC C)Apr 1, 2001 - Jan 31, 2013
    NIH/NCI
    REGULATION OF GENETIC STABILITY BY THE INT6 FAMILY
    Role: Principal Investigator
    R01CA107187     (CHANG, ERIC C)Apr 19, 2005 - Mar 31, 2009
    NIH/NCI
    Selective control of multiple Ras signaling activities
    Role: Principal Investigator
    R21CA226567     (CHANG, ERIC C)Jun 4, 2018 - May 31, 2020
    NIH/NCI
    A novel N-Ras pathway driving DCIS to basal-like breast cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Zheng ZY, Li J, Li F, Zhu Y, Cui K, Wong ST, Chang EC, Liao YH. Induction of N-Ras degradation by flunarizine-mediated autophagy. Sci Rep. 2018 Nov 16; 8(1):16932. PMID: 30446677.
      View in: PubMed
    2. Griffith OL, Spies NC, Anurag M, Griffith M, Luo J, Tu D, Yeo B, Kunisaki J, Miller CA, Krysiak K, Hundal J, Ainscough BJ, Skidmore ZL, Campbell K, Kumar R, Fronick C, Cook L, Snider JE, Davies S, Kavuri SM, Chang EC, Magrini V, Larson DE, Fulton RS, Liu S, Leung S, Voduc D, Bose R, Dowsett M, Wilson RK, Nielsen TO, Mardis ER, Ellis MJ. Author Correction: The prognostic effects of somatic mutations in ER-positive breast cancer. Nat Commun. 2018 11 14; 9(1):4850. PMID: 30429476.
      View in: PubMed
    3. Griffith OL, Spies NC, Anurag M, Griffith M, Luo J, Tu D, Yeo B, Kunisaki J, Miller CA, Krysiak K, Hundal J, Ainscough BJ, Skidmore ZL, Campbell K, Kumar R, Fronick C, Cook L, Snider JE, Davies S, Kavuri SM, Chang EC, Magrini V, Larson DE, Fulton RS, Liu S, Leung S, Voduc D, Bose R, Dowsett M, Wilson RK, Nielsen TO, Mardis ER, Ellis MJ. The prognostic effects of somatic mutations in ER-positive breast cancer. Nat Commun. 2018 09 04; 9(1):3476. PMID: 30181556.
      View in: PubMed
    4. Zheng ZY, Tian L, Bu W, Fan C, Gao X, Wang H, Liao YH, Li Y, Lewis MT, Edwards D, Zwaka TP, Hilsenbeck SG, Medina D, Perou CM, Creighton CJ, Zhang XH, Chang EC. Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation. Cell Rep. 2015 Jul 21; 12(3):511-24. PMID: 26166574.
      View in: PubMed
    5. Suo J, Medina D, Herrera S, Zheng ZY, Jin L, Chamness GC, Contreras A, Gutierrez C, Hilsenbeck S, Umar A, Foekens JA, Hanash S, Schiff R, Zhang XH, Chang EC. Int6 reduction activates stromal fibroblasts to enhance transforming activity in breast epithelial cells. Cell Biosci. 2015; 5:10. PMID: 25774287.
      View in: PubMed
    6. Veeraraghavan J, Tan Y, Cao XX, Kim JA, Wang X, Chamness GC, Maiti SN, Cooper LJ, Edwards DP, Contreras A, Hilsenbeck SG, Chang EC, Schiff R, Wang XS. Recurrent ESR1-CCDC170 rearrangements in an aggressive subset of oestrogen receptor-positive breast cancers. Nat Commun. 2014 Aug 07; 5:4577. PMID: 25099679.
      View in: PubMed
    7. Zheng ZY, Chang EC. A bimolecular fluorescent complementation screen reveals complex roles of endosomes in Ras-mediated signaling. Methods Enzymol. 2014; 535:25-38. PMID: 24377915.
      View in: PubMed
    8. Chen. X, Zhu, Y., Zhu, Li, F., Zheng, Z., Chang, E., Ma, J. and Wong, Stephen W. Accurate Segmentation of Touching Cells in Multi-channel Microscopy Images with Geodesic Distance Based Clustering. Neurocomputing. 2014; In press..
    9. Young E, Zheng ZY, Wilkins AD, Jeong HT, Li M, Lichtarge O, Chang EC. Regulation of Ras localization and cell transformation by evolutionarily conserved palmitoyltransferases. Mol Cell Biol. 2014 Feb; 34(3):374-85. PMID: 24248599.
      View in: PubMed
    10. Chen. X, Zhu, Y., Zhu, Li, F., Zheng, Z., Chang, E., Ma, J. and Wong, Stephen W. International Symposium on Neural Networks (ISNN13). A Novel Geodesic Distance Based Clustering Approach to Delineating Boundaries of Touching Cells. 2013; 7952:315-322.
    11. Zheng ZY, Xu L, Bar-Sagi D, Chang EC. Escorting Ras. Small GTPases. 2012 Oct-Dec; 3(4):236-9. PMID: 22735486.
      View in: PubMed
    12. Zheng ZY, Cheng CM, Fu XR, Chen LY, Xu L, Terrillon S, Wong ST, Bar-Sagi D, Songyang Z, Chang EC. CHMP6 and VPS4A mediate the recycling of Ras to the plasma membrane to promote growth factor signaling. Oncogene. 2012 Oct 25; 31(43):4630-8. PMID: 22231449.
      View in: PubMed
    13. Cheng CM, Chang EC. Busy traveling Ras. Cell Cycle. 2011 Apr 15; 10(8):1180-1. PMID: 21436618.
      View in: PubMed
    14. Cabrera R, Suo J, Young E, Chang EC. Schizosaccharomyces pombe Arc3 is a conserved subunit of the Arp2/3 complex required for polarity, actin organization, and endocytosis. Yeast. 2011 Jun; 28(6):495-503. PMID: 21449051.
      View in: PubMed
    15. Cheng CM, Li H, Gasman S, Huang J, Schiff R, Chang EC. Compartmentalized Ras proteins transform NIH 3T3 cells with different efficiencies. Mol Cell Biol. 2011 Mar; 31(5):983-97. PMID: 21189290.
      View in: PubMed
    16. Suo J, Snider SJ, Mills GB, Creighton CJ, Chen AC, Schiff R, Lloyd RE, Chang EC. Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium. Oncogene. 2011 Feb 10; 30(6):724-36. PMID: 20890303.
      View in: PubMed
    17. Gilbert MR, Gonzalez J, Hunter K, Hess K, Giglio P, Chang E, Puduvalli V, Groves MD, Colman H, Conrad C, Levin V, Woo S, Mahajan A, de Groot J, Yung WK. A phase I factorial design study of dose-dense temozolomide alone and in combination with thalidomide, isotretinoin, and/or celecoxib as postchemoradiation adjuvant therapy for newly diagnosed glioblastoma. Neuro Oncol. 2010 Nov; 12(11):1167-72. PMID: 20729242.
      View in: PubMed
    18. Cabrera R, Sha Z, Vadakkan TJ, Otero J, Kriegenburg F, Hartmann-Petersen R, Dickinson ME, Chang EC. Proteasome nuclear import mediated by Arc3 can influence efficient DNA damage repair and mitosis in Schizosaccharomyces pombe. Mol Biol Cell. 2010 Sep 15; 21(18):3125-36. PMID: 20668161.
      View in: PubMed
    19. Otero JH, Suo J, Gordon C, Chang EC. Int6 and Moe1 interact with Cdc48 to regulate ERAD and proper chromosome segregation. Cell Cycle. 2010 Jan 01; 9(1):147-61. PMID: 20016281.
      View in: PubMed
    20. Sha Z, Brill LM, Cabrera R, Kleifeld O, Scheliga JS, Glickman MH, Chang EC, Wolf DA. The eIF3 interactome reveals the translasome, a supercomplex linking protein synthesis and degradation machineries. Mol Cell. 2009 Oct 09; 36(1):141-52. PMID: 19818717.
      View in: PubMed
    21. Sha Z, Yen HC, Scheel H, Suo J, Hofmann K, Chang EC. Isolation of the Schizosaccharomyces pombe proteasome subunit Rpn7 and a structure-function study of the proteasome-COP9-initiation factor domain. J Biol Chem. 2007 Nov 02; 282(44):32414-23. PMID: 17761670.
      View in: PubMed
    22. Chang EC, Philips MR. Spatial segregation of Ras signaling: new evidence from fission yeast. Cell Cycle. 2006 Sep; 5(17):1936-9. PMID: 16931912.
      View in: PubMed
    23. Onken B, Wiener H, Philips MR, Chang EC. Compartmentalized signaling of Ras in fission yeast. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9045-50. PMID: 16754851.
      View in: PubMed
    24. Chang EC, Schwechheimer C. ZOMES III: the interface between signalling and proteolysis. Meeting on The COP9 Signalosome, Proteasome and eIF3. EMBO Rep. 2004 Nov; 5(11):1041-5. PMID: 15514681.
      View in: PubMed
    25. Li Y, Chang EC. Schizosaccharomyces pombe Ras1 effector, Scd1, interacts with Klp5 and Klp6 kinesins to mediate cytokinesis. Genetics. 2003 Oct; 165(2):477-88. PMID: 14573463.
      View in: PubMed
    26. Yen HC, Espiritu C, Chang EC. Rpn5 is a conserved proteasome subunit and required for proper proteasome localization and assembly. J Biol Chem. 2003 Aug 15; 278(33):30669-76. PMID: 12783882.
      View in: PubMed
    27. Yen HC, Chang EC. INT6--a link between the proteasome and tumorigenesis. Cell Cycle. 2003 Mar-Apr; 2(2):81-3. PMID: 12695651.
      View in: PubMed
    28. Yen HC, Gordon C, Chang EC. Schizosaccharomyces pombe Int6 and Ras homologs regulate cell division and mitotic fidelity via the proteasome. Cell. 2003 Jan 24; 112(2):207-17. PMID: 12553909.
      View in: PubMed
    29. Papadaki P, Pizon V, Onken B, Chang EC. Two ras pathways in fission yeast are differentially regulated by two ras guanine nucleotide exchange factors. Mol Cell Biol. 2002 Jul; 22(13):4598-606. PMID: 12052869.
      View in: PubMed
    30. Bandyopadhyay A, Lakshmanan V, Matsumoto T, Chang EC, Maitra U. Moe1 and spInt6, the fission yeast homologues of mammalian translation initiation factor 3 subunits p66 (eIF3d) and p48 (eIF3e), respectively, are required for stable association of eIF3 subunits. J Biol Chem. 2002 Jan 18; 277(3):2360-7. PMID: 11705997.
      View in: PubMed
    31. Yen HC, Chang EC. Yin6, a fission yeast Int6 homolog, complexes with Moe1 and plays a role in chromosome segregation. Proc Natl Acad Sci U S A. 2000 Dec 19; 97(26):14370-5. PMID: 11121040.
      View in: PubMed
    32. Chen CR, Chen J, Chang EC. A conserved interaction between Moe1 and Mal3 is important for proper spindle formation in Schizosaccharomyces pombe. Mol Biol Cell. 2000 Dec; 11(12):4067-77. PMID: 11102508.
      View in: PubMed
    33. Li YC, Chen CR, Chang EC. Fission yeast Ras1 effector Scd1 interacts with the spindle and affects its proper formation. Genetics. 2000 Nov; 156(3):995-1004. PMID: 11063680.
      View in: PubMed
    34. Chen CR, Li YC, Chen J, Hou MC, Papadaki P, Chang EC. Moe1, a conserved protein in Schizosaccharomyces pombe, interacts with a Ras effector, Scd1, to affect proper spindle formation. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):517-22. PMID: 9892665.
      View in: PubMed
    35. Marcus S, Polverino A, Chang E, Robbins D, Cobb MH, Wigler MH. Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe. Proc Natl Acad Sci U S A. 1995 Jun 20; 92(13):6180-4. PMID: 7597098.
      View in: PubMed
    36. Chang EC, Barr M, Wang Y, Jung V, Xu HP, Wigler MH. Cooperative interaction of S. pombe proteins required for mating and morphogenesis. Cell. 1994 Oct 07; 79(1):131-41. PMID: 7923372.
      View in: PubMed
    37. Andersen LB, Ballester R, Marchuk DA, Chang E, Gutmann DH, Saulino AM, Camonis J, Wigler M, Collins FS. A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity. Mol Cell Biol. 1993 Jan; 13(1):487-95. PMID: 8417346.
      View in: PubMed
    38. Shibuya EK, Polverino AJ, Chang E, Wigler M, Ruderman JV. Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes. Proc Natl Acad Sci U S A. 1992 Oct 15; 89(20):9831-5. PMID: 1384061.
      View in: PubMed
    39. Chang EC, Crawford BF, Hong Z, Bilinski T, Kosman DJ. Genetic and biochemical characterization of Cu,Zn superoxide dismutase mutants in Saccharomyces cerevisiae. J Biol Chem. 1991 Mar 05; 266(7):4417-24. PMID: 1999425.
      View in: PubMed
    40. Chang EC, Kosman DJ. O2-dependent methionine auxotrophy in Cu,Zn superoxide dismutase-deficient mutants of Saccharomyces cerevisiae. J Bacteriol. 1990 Apr; 172(4):1840-5. PMID: 2180907.
      View in: PubMed
    41. Chang EC, Kosman DJ, Willsky GR. Arsenic oxide-induced thermotolerance in Saccharomyces cerevisiae. J Bacteriol. 1989 Nov; 171(11):6349-52. PMID: 2681165.
      View in: PubMed
    42. Chang EC, Kosman DJ. Intracellular Mn (II)-associated superoxide scavenging activity protects Cu,Zn superoxide dismutase-deficient Saccharomyces cerevisiae against dioxygen stress. J Biol Chem. 1989 Jul 25; 264(21):12172-8. PMID: 2545701.
      View in: PubMed
    43. Gralla, E. B., Bermingham-McDonogh, O., Valentine, J. S. Chang, E. C., Frueger, T., Kosman, D. J. . Cloning and Biological Activity of the Cu, Zn SOD gene of S. cerevisiae. UCLA Symp. Mol. Cell. Biol. New Ser. 1988; 82:173-182.
    CHANG's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    See all (253) concept(s)
    _
    Co-Authors Expand Description
    See all (22) people
    _
    Similar People Expand Description
    See all (60) people
    _
    Same Department Expand Description
    Search Department