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Institute for Clinical and Translational Research

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ERIC CHANG

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentBreast Center
    DivisionBreast Cancer Center


    Collapse ORNG Applications 
    Collapse Verify Publications

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    Collapse research activities and funding
    R01CA090464     (CHANG, ERIC C)Apr 1, 2001 - Nov 1, 2002
    NIH/NCI
    REGULATION OF GENETIC STABILITY BY THE INT6 FAMILY
    Role: Principal Investigator
    R01CA107187     (CHANG, ERIC C)Apr 19, 2005 - Mar 31, 2009
    NIH/NCI
    Selective control of multiple Ras signaling activities
    Role: Principal Investigator
    R21CA226567     (CHANG, ERIC C)Jun 4, 2018 - May 31, 2020
    NIH/NCI
    A novel N-Ras pathway driving DCIS to basal-like breast cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Bernhardt D, Wick W, Weiss SE, Sahgal A, Lo SS, Suh JH, Chang EL, Foote M, Perry J, Meyer B, Vajkoczy P, Wen PY, Straube C, Pigorsch S, Wilkens JJ, Combs SE. Neuro-oncology Management During the COVID-19 Pandemic With a Focus on WHO Grade III and IV Gliomas. Neuro Oncol. 2020 May 05. PMID: 32369601.
      View in: PubMed
    2. Ludmir EB, Mahajan A, Ahern V, Ajithkumar T, Alapetite C, Bernier-Chastagner V, Bindra RS, Bishop AJ, Bolle S, Brown PD, Carrie C, Chalmers AJ, Chang EL, Chung C, Dieckmann K, Esiashvili N, Gandola L, Ghia AJ, Gondi V, Grosshans DR, Harrabi SB, Horan G, Indelicato DJ, Jalali R, Janssens GO, Krause M, Laack NN, Laperriere N, Laprie A, Li J, Marcus KJ, McGovern SL, Merchant TE, Merrell KW, Padovani L, Parkes J, Paulino AC, Schwarz R, Shih HA, Souhami L, Sulman EP, Taylor RE, Thorp N, Timmermann B, Wheeler G, Wolden SL, Woodhouse KD, Yeboa DN, Yock TI, Kortmann RD, McAleer MF. Assembling the brain trust: the multidisciplinary imperative in neuro-oncology. Nat Rev Clin Oncol. 2019 08; 16(8):521-522. PMID: 31150024.
      View in: PubMed
    3. Jerban S, Lu X, Jang H, Ma Y, Namiranian B, Le N, Li Y, Chang EY, Du J. Significant correlations between human cortical bone mineral density and quantitative susceptibility mapping (QSM) obtained with 3D Cones ultrashort echo time magnetic resonance imaging (UTE-MRI). Magn Reson Imaging. 2019 10; 62:104-110. PMID: 31247253.
      View in: PubMed
    4. Kotecha R, Mehta MP, Chang EL, Brown PD, Suh JH, Lo SS, Das S, Samawi HH, Keith J, Perry J, Sahgal A. Updates in the management of intradural spinal cord tumors: a radiation oncology focus. Neuro Oncol. 2019 06 10; 21(6):707-718. PMID: 30977511.
      View in: PubMed
    5. Ghia AJ, Guha-Thakurta N, Hess K, Yang JN, Settle SH, Sharpe HJ, Li J, McAleer M, Chang EL, Tatsui CE, Brown PD, Rhines LD. Phase 1 Study of Spinal Cord Constraint Relaxation With Single Session Spine Stereotactic Radiosurgery in the Primary Management of Patients With Inoperable, Previously Unirradiated Metastatic Epidural Spinal Cord Compression. Int J Radiat Oncol Biol Phys. 2018 12 01; 102(5):1481-1488. PMID: 30099131.
      View in: PubMed
    6. Laufer I, Lo SS, Chang EL, Sheehan J, Guckenberger M, Sohn MJ, Ryu S, Foote M, Muacevic A, Soltys SG, Chao S, Myrehaug S, Gerszten PC, Lis E, Maralani P, Bilsky M, Fisher C, Rhines L, Verlaan JJ, Schiff D, Fehlings MG, Ma L, Chang S, Parulekar WR, Vogelbaum MA, Sahgal A. Population description and clinical response assessment for spinal metastases: part 2 of the SPIne response assessment in Neuro-Oncology (SPINO) group report. Neuro Oncol. 2018 08 02; 20(9):1215-1224. PMID: 29590465.
      View in: PubMed
    7. Diao K, Bian SX, Routman DM, Yu C, Ye JC, Wagle NA, Wong MK, Zada G, Chang EL. Stereotactic radiosurgery and ipilimumab for patients with melanoma brain metastases: clinical outcomes and toxicity. J Neurooncol. 2018 Sep; 139(2):421-429. PMID: 29696531.
      View in: PubMed
    8. Wang X, Zhao Z, Luo D, Yang JN, Yang J, Chang EL, Brown PD, Li J, McAleer MF, Ghia AJ. Submillimeter alignment of more than three contiguous vertebrae in spinal SRS/SBRT with 6-degree couch. J Appl Clin Med Phys. 2017 Sep; 18(5):225-236. PMID: 28786235.
      View in: PubMed
    9. Bishop AJ, Tao R, Guadagnolo BA, Allen PK, Rebueno NC, Wang XA, Amini B, Tatsui CE, Rhines LD, Li J, Chang EL, Brown PD, Ghia AJ. Spine stereotactic radiosurgery for metastatic sarcoma: patterns of failure and radiation treatment volume considerations. J Neurosurg Spine. 2017 Sep; 27(3):303-311. PMID: 28644075.
      View in: PubMed
    10. Bernstein MB, Chang EL, Amini B, Pan H, Cabanillas M, Wang XA, Allen PK, Rhines LD, Tatsui C, Li J, Brown PD, Ghia AJ. Spine Stereotactic Radiosurgery for Patients with Metastatic Thyroid Cancer: Secondary Analysis of Phase I/II Trials. Thyroid. 2016 09; 26(9):1269-75. PMID: 27334245.
      View in: PubMed
    11. Tao R, Bishop AJ, Brownlee Z, Allen PK, Settle SH, Chang EL, Wang X, Amini B, Tannir NM, Tatsui C, Rhines LD, Brown PD, Ghia AJ. Stereotactic Body Radiation Therapy for Spinal Metastases in the Postoperative Setting: A Secondary Analysis of Mature Phase 1-2 Trials. Int J Radiat Oncol Biol Phys. 2016 08 01; 95(5):1405-1413. PMID: 27209509.
      View in: PubMed
    12. Soffietti R, Rudà R, Trakul N, Chang EL. Point/Counterpoint: Is stereotactic radiosurgery needed following resection of brain metastasis? Neuro Oncol. 2016 Jan; 18(1):12-5. PMID: 26667138.
      View in: PubMed
    13. Weksberg DC, Yang JN, Tam AL, Li J, Wang XA, Zhao Z, McRae SE, Settle SH, Rhines LD, Chang EL, Brown PD, Ghia AJ. Prospective validation of treatment accuracy using implanted fiducial markers for spinal stereotactic body radiation therapy. J Radiosurg SBRT. 2016; 4(1):7-14. PMID: 29296421.
      View in: PubMed
    14. Wang X, Ghia AJ, Zhao Z, Yang J, Luo D, Briere TM, Pino R, Li J, McAleer MF, Weksberg DC, Chang EL, Brown PD, Yang JN. Prospective evaluation of target and spinal cord motion and dosimetric changes with respiration in spinal stereotactic body radiation therapy utilizing 4-D CT. J Radiosurg SBRT. 2016; 4(3):191-201. PMID: 29296444.
      View in: PubMed
    15. Kumar R, Nater A, Hashmi A, Myrehaug S, Lee Y, Ma L, Redmond K, Lo SS, Chang EL, Yee A, Fisher CG, Fehlings MG, Sahgal A. The era of stereotactic body radiotherapy for spinal metastases and the multidisciplinary management of complex cases. Neurooncol Pract. 2016 Mar; 3(1):48-58. PMID: 31579521.
      View in: PubMed
    16. Bishop AJ, Tao R, Rebueno NC, Christensen EN, Allen PK, Wang XA, Amini B, Tannir NM, Tatsui CE, Rhines LD, Li J, Chang EL, Brown PD, Ghia AJ. Outcomes for Spine Stereotactic Body Radiation Therapy and an Analysis of Predictors of Local Recurrence. Int J Radiat Oncol Biol Phys. 2015 Aug 01; 92(5):1016-1026. PMID: 26025777.
      View in: PubMed
    17. Parikh NR, Likhacheva A, Pinnix C, Allen PK, Prabhu SS, Guha-Thakurta N, Welsh JW, Brown PD, Chang EL. Prognostic significance of EGFR and KRAS mutations in NSCLC patients with brain metastases treated with radiosurgery†. J Radiosurg SBRT. 2015; 3(3):171-178. PMID: 29296399.
      View in: PubMed
    18. Sellin JN, Reichardt W, Bishop AJ, Suki D, Rhines LD, Settle SH, Brown PD, Li J, Rao G, Chang EL, Tatsui CE. Factors affecting survival in 37 consecutive patients undergoing de novo stereotactic radiosurgery for contiguous sites of vertebral body metastasis from renal cell carcinoma. J Neurosurg Spine. 2015 Jan; 22(1):52-9. PMID: 25360530.
      View in: PubMed
    19. Grosshans DR, Zhu XR, Melancon A, Allen PK, Poenisch F, Palmer M, McAleer MF, McGovern SL, Gillin M, DeMonte F, Chang EL, Brown PD, Mahajan A. Spot scanning proton therapy for malignancies of the base of skull: treatment planning, acute toxicities, and preliminary clinical outcomes. Int J Radiat Oncol Biol Phys. 2014 Nov 01; 90(3):540-6. PMID: 25304948.
      View in: PubMed
    20. Penas-Prado M, Hess KR, Fisch MJ, Lagrone LW, Groves MD, Levin VA, De Groot JF, Puduvalli VK, Colman H, Volas-Redd G, Giglio P, Conrad CA, Salacz ME, Floyd JD, Loghin ME, Hsu SH, Gonzalez J, Chang EL, Woo SY, Mahajan A, Aldape KD, Yung WK, Gilbert MR. Randomized phase II adjuvant factorial study of dose-dense temozolomide alone and in combination with isotretinoin, celecoxib, and/or thalidomide for glioblastoma. Neuro Oncol. 2015 Feb; 17(2):266-73. PMID: 25239666.
      View in: PubMed
    21. Pan HY, Allen PK, Wang XS, Chang EL, Rhines LD, Tatsui CE, Amini B, Wang XA, Tannir NM, Brown PD, Ghia AJ. Incidence and predictive factors of pain flare after spine stereotactic body radiation therapy: secondary analysis of phase 1/2 trials. Int J Radiat Oncol Biol Phys. 2014 Nov 15; 90(4):870-6. PMID: 25227497.
      View in: PubMed
    22. Zhu XR, Poenisch F, Li H, Zhang X, Sahoo N, Wu RY, Li X, Lee AK, Chang EL, Choi S, Pugh T, Frank SJ, Gillin MT, Mahajan A, Grosshans DR. A single-field integrated boost treatment planning technique for spot scanning proton therapy. Radiat Oncol. 2014 Sep 11; 9:202. PMID: 25212571.
      View in: PubMed
    23. Tsai CJ, Wang Y, Allen PK, Mahajan A, McCutcheon IE, Rao G, Rhines LD, Tatsui CE, Armstrong TS, Maor MH, Chang EL, Brown PD, Li J. Outcomes after surgery and radiotherapy for spinal myxopapillary ependymoma: update of the MD Anderson Cancer Center experience. Neurosurgery. 2014 Sep; 75(3):205-14; discussion 213-4. PMID: 24818785.
      View in: PubMed
    24. Veeraraghavan J, Tan Y, Cao XX, Kim JA, Wang X, Chamness GC, Maiti SN, Cooper LJ, Edwards DP, Contreras A, Hilsenbeck SG, Chang EC, Schiff R, Wang XS. Recurrent ESR1-CCDC170 rearrangements in an aggressive subset of oestrogen receptor-positive breast cancers. Nat Commun. 2014 Aug 07; 5:4577. PMID: 25099679.
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    25. Lam TC, Sahgal A, Chang EL, Lo SS. Stereotactic radiosurgery for multiple brain metastases. Expert Rev Anticancer Ther. 2014 Oct; 14(10):1153-72. PMID: 25034143.
      View in: PubMed
    26. Zheng ZY, Chang EC. A bimolecular fluorescent complementation screen reveals complex roles of endosomes in Ras-mediated signaling. Methods Enzymol. 2014; 535:25-38. PMID: 24377915.
      View in: PubMed
    27. Chen. X, Zhu, Y., Zhu, Li, F., Zheng, Z., Chang, E., Ma, J. and Wong, Stephen W. Accurate Segmentation of Touching Cells in Multi-channel Microscopy Images with Geodesic Distance Based Clustering. Neurocomputing. 2014; In press..
    28. Verma J, Jonasch E, Allen PK, Weinberg JS, Tannir N, Chang EL, Mahajan A. The impact of tyrosine kinase inhibitors on the multimodality treatment of brain metastases from renal cell carcinoma. Am J Clin Oncol. 2013 Dec; 36(6):620-4. PMID: 22892430.
      View in: PubMed
    29. Young E, Zheng ZY, Wilkins AD, Jeong HT, Li M, Lichtarge O, Chang EC. Regulation of Ras localization and cell transformation by evolutionarily conserved palmitoyltransferases. Mol Cell Biol. 2014 Feb; 34(3):374-85. PMID: 24248599.
      View in: PubMed
    30. Ghia AJ, Chang EL, Allen PK, Mahajan A, Penas-Prado M, McCutcheon IE, Brown PD. Intracranial hemangiopericytoma: patterns of failure and the role of radiation therapy. Neurosurgery. 2013 Oct; 73(4):624-30; discussion 630-1. PMID: 23839520.
      View in: PubMed
    31. Chen. X, Zhu, Y., Zhu, Li, F., Zheng, Z., Chang, E., Ma, J. and Wong, Stephen W. International Symposium on Neural Networks (ISNN13). A Novel Geodesic Distance Based Clustering Approach to Delineating Boundaries of Touching Cells. 2013; 7952:315-322.
    32. Likhacheva A, Pinnix CC, Parikh N, Allen PK, Guha-Thakurta N, McAleer M, Sulman EP, Mahajan A, Shiu A, Luo D, Chiu M, Brown PD, Prabhu SS, Chang EL. Validation of Recursive Partitioning Analysis and Diagnosis-Specific Graded Prognostic Assessment in patients treated initially with radiosurgery alone. J Neurosurg. 2012 Dec; 117 Suppl:38-44. PMID: 23205787.
      View in: PubMed
    33. Likhacheva A, Pinnix CC, Parikh NR, Allen PK, McAleer MF, Chiu MS, Sulman EP, Mahajan A, Guha-Thakurta N, Prabhu SS, Cahill DP, Luo D, Shiu AS, Brown PD, Chang EL. Predictors of survival in contemporary practice after initial radiosurgery for brain metastases. Int J Radiat Oncol Biol Phys. 2013 Mar 01; 85(3):656-61. PMID: 22898384.
      View in: PubMed
    34. Zheng ZY, Xu L, Bar-Sagi D, Chang EC. Escorting Ras. Small GTPases. 2012 Oct-Dec; 3(4):236-9. PMID: 22735486.
      View in: PubMed
    35. Garg AK, Shiu AS, Yang J, Wang XS, Allen P, Brown BW, Grossman P, Frija EK, McAleer MF, Azeem S, Brown PD, Rhines LD, Chang EL. Phase 1/2 trial of single-session stereotactic body radiotherapy for previously unirradiated spinal metastases. Cancer. 2012 Oct 15; 118(20):5069-77. PMID: 22511344.
      View in: PubMed
    36. Weksberg DC, Bilton SD, Chang EL. Use of a deformable atlas to identify cryptic critical structures in the treatment of glioblastoma multiforme. PLoS One. 2012; 7(3):e32098. PMID: 22461883.
      View in: PubMed
    37. Weksberg DC, Palmer MB, Vu KN, Rebueno NC, Sharp HJ, Luo D, Yang JN, Shiu AS, Rhines LD, McAleer MF, Brown PD, Chang EL. Generalizable class solutions for treatment planning of spinal stereotactic body radiation therapy. Int J Radiat Oncol Biol Phys. 2012 Nov 01; 84(3):847-53. PMID: 22445000.
      View in: PubMed
    38. Wang XS, Rhines LD, Shiu AS, Yang JN, Selek U, Gning I, Liu P, Allen PK, Azeem SS, Brown PD, Sharp HJ, Weksberg DC, Cleeland CS, Chang EL. Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1-2 trial. Lancet Oncol. 2012 Apr; 13(4):395-402. PMID: 22285199.
      View in: PubMed
    39. Zheng ZY, Cheng CM, Fu XR, Chen LY, Xu L, Terrillon S, Wong ST, Bar-Sagi D, Songyang Z, Chang EC. CHMP6 and VPS4A mediate the recycling of Ras to the plasma membrane to promote growth factor signaling. Oncogene. 2012 Oct 25; 31(43):4630-8. PMID: 22231449.
      View in: PubMed
    40. Boehling NS, Grosshans DR, Allen PK, McAleer MF, Burton AW, Azeem S, Rhines LD, Chang EL. Vertebral compression fracture risk after stereotactic body radiotherapy for spinal metastases. J Neurosurg Spine. 2012 Apr; 16(4):379-86. PMID: 22225488.
      View in: PubMed
    41. Pinnix CC, Fontanilla HP, Hayes-Jordan A, Subbiah V, Bilton SD, Chang EL, Grosshans DR, McAleer MF, Sulman EP, Woo SY, Anderson P, Green HL, Mahajan A. Whole abdominopelvic intensity-modulated radiation therapy for desmoplastic small round cell tumor after surgery. Int J Radiat Oncol Biol Phys. 2012 May 01; 83(1):317-26. PMID: 22104361.
      View in: PubMed
    42. Hatiboglu MA, Chang EL, Suki D, Sawaya R, Wildrick DM, Weinberg JS. Outcomes and prognostic factors for patients with brainstem metastases undergoing stereotactic radiosurgery. Neurosurgery. 2011 Oct; 69(4):796-806; discussion 806. PMID: 21508879.
      View in: PubMed
    43. Wolff JE, Rytting M, Vats T, Ater J, Mahajan A, Woo S, Ketonen L, Kuttesch J, Liu D, Thall P, Chang EL. Induction treatment for diffuse intrinsic pontine glioma, experience of M.D. Anderson Cancer Center. Anticancer Res. 2011 Jun; 31(6):2265-9. PMID: 21737651.
      View in: PubMed
    44. Cheng CM, Chang EC. Busy traveling Ras. Cell Cycle. 2011 Apr 15; 10(8):1180-1. PMID: 21436618.
      View in: PubMed
    45. Cabrera R, Suo J, Young E, Chang EC. Schizosaccharomyces pombe Arc3 is a conserved subunit of the Arp2/3 complex required for polarity, actin organization, and endocytosis. Yeast. 2011 Jun; 28(6):495-503. PMID: 21449051.
      View in: PubMed
    46. Garg AK, Wang XS, Shiu AS, Allen P, Yang J, McAleer MF, Azeem S, Rhines LD, Chang EL. Prospective evaluation of spinal reirradiation by using stereotactic body radiation therapy: The University of Texas MD Anderson Cancer Center experience. Cancer. 2011 Aug 01; 117(15):3509-16. PMID: 21319143.
      View in: PubMed
    47. Walker GV, Ahmed S, Allen P, Gidley PW, Woo SY, DeMonte F, Chang EL, Mahajan A. Radiation-induced middle ear and mastoid opacification in skull base tumors treated with radiotherapy. Int J Radiat Oncol Biol Phys. 2011 Dec 01; 81(5):e819-23. PMID: 21277110.
      View in: PubMed
    48. Cheng CM, Li H, Gasman S, Huang J, Schiff R, Chang EC. Compartmentalized Ras proteins transform NIH 3T3 cells with different efficiencies. Mol Cell Biol. 2011 Mar; 31(5):983-97. PMID: 21189290.
      View in: PubMed
    49. Suo J, Snider SJ, Mills GB, Creighton CJ, Chen AC, Schiff R, Lloyd RE, Chang EC. Int6 regulates both proteasomal degradation and translation initiation and is critical for proper formation of acini by human mammary epithelium. Oncogene. 2011 Feb 10; 30(6):724-36. PMID: 20890303.
      View in: PubMed
    50. Gilbert MR, Gonzalez J, Hunter K, Hess K, Giglio P, Chang E, Puduvalli V, Groves MD, Colman H, Conrad C, Levin V, Woo S, Mahajan A, de Groot J, Yung WK. A phase I factorial design study of dose-dense temozolomide alone and in combination with thalidomide, isotretinoin, and/or celecoxib as postchemoradiation adjuvant therapy for newly diagnosed glioblastoma. Neuro Oncol. 2010 Nov; 12(11):1167-72. PMID: 20729242.
      View in: PubMed
    51. Cabrera R, Sha Z, Vadakkan TJ, Otero J, Kriegenburg F, Hartmann-Petersen R, Dickinson ME, Chang EC. Proteasome nuclear import mediated by Arc3 can influence efficient DNA damage repair and mitosis in Schizosaccharomyces pombe. Mol Biol Cell. 2010 Sep 15; 21(18):3125-36. PMID: 20668161.
      View in: PubMed
    52. Du W, Yang JN, Chang EL, Luo D, McAleer MF, Shiu A, Martel MK. A quality assurance procedure to evaluate cone-beam CT image center congruence with the radiation isocenter of a linear accelerator. J Appl Clin Med Phys. 2010 Jul 02; 11(4):3297. PMID: 21081890.
      View in: PubMed
    53. Otero JH, Suo J, Gordon C, Chang EC. Int6 and Moe1 interact with Cdc48 to regulate ERAD and proper chromosome segregation. Cell Cycle. 2010 Jan 01; 9(1):147-61. PMID: 20016281.
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    54. Sha Z, Brill LM, Cabrera R, Kleifeld O, Scheliga JS, Glickman MH, Chang EC, Wolf DA. The eIF3 interactome reveals the translasome, a supercomplex linking protein synthesis and degradation machineries. Mol Cell. 2009 Oct 09; 36(1):141-52. PMID: 19818717.
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    55. Chang EL, Wefel JS, Hess KR, Allen PK, Lang FF, Kornguth DG, Arbuckle RB, Swint JM, Shiu AS, Maor MH, Meyers CA. Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial. Lancet Oncol. 2009 Nov; 10(11):1037-44. PMID: 19801201.
      View in: PubMed
    56. Nguyen QN, Shiu AS, Rhines LD, Wang H, Allen PK, Wang XS, Chang EL. Management of spinal metastases from renal cell carcinoma using stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys. 2010 Mar 15; 76(4):1185-92. PMID: 19632064.
      View in: PubMed
    57. Torres MA, Chang EL, Mahajan A, Lege DG, Riley BA, Zhang X, Lii M, Kornguth DG, Pelloski CE, Woo SY. Optimal treatment planning for skull base chordoma: photons, protons, or a combination of both? Int J Radiat Oncol Biol Phys. 2009 Jul 15; 74(4):1033-9. PMID: 19356861.
      View in: PubMed
    58. Hadziahmetovic M, Clarke JW, Cavaliere R, Mayr NA, Montebello JF, Grecula JC, Newton HB, Chang EL, Lo SS. CNS germinomas: what is the best treatment strategy? Expert Rev Neurother. 2008 Oct; 8(10):1527-36. PMID: 18928345.
      View in: PubMed
    59. Nguyen QN, Chang EL. Emerging role of proton beam radiation therapy for chordoma and chondrosarcoma of the skull base. Curr Oncol Rep. 2008 Jul; 10(4):338-43. PMID: 18778560.
      View in: PubMed
    60. Wang H, Shiu A, Wang C, O'Daniel J, Mahajan A, Woo S, Liengsawangwong P, Mohan R, Chang EL. Dosimetric effect of translational and rotational errors for patients undergoing image-guided stereotactic body radiotherapy for spinal metastases. Int J Radiat Oncol Biol Phys. 2008 Jul 15; 71(4):1261-71. PMID: 18485614.
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    61. Clarke JW, Chang EL, Levin VA, Mayr NA, Hong E, Cavaliere R, Lo SS. Optimizing radiotherapy schedules for elderly glioblastoma multiforme patients. Expert Rev Anticancer Ther. 2008 May; 8(5):733-41. PMID: 18471046.
      View in: PubMed
    62. Mahajan A, Woo SY, Kornguth DG, Hughes D, Huh W, Chang EL, Herzog CE, Pelloski CE, Anderson P. Multimodality treatment of osteosarcoma: radiation in a high-risk cohort. Pediatr Blood Cancer. 2008 May; 50(5):976-82. PMID: 18213710.
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    63. Sha Z, Yen HC, Scheel H, Suo J, Hofmann K, Chang EC. Isolation of the Schizosaccharomyces pombe proteasome subunit Rpn7 and a structure-function study of the proteasome-COP9-initiation factor domain. J Biol Chem. 2007 Nov 02; 282(44):32414-23. PMID: 17761670.
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    64. Chang EL, Shiu AS, Mendel E, Mathews LA, Mahajan A, Allen PK, Weinberg JS, Brown BW, Wang XS, Woo SY, Cleeland C, Maor MH, Rhines LD. Phase I/II study of stereotactic body radiotherapy for spinal metastasis and its pattern of failure. J Neurosurg Spine. 2007 Aug; 7(2):151-60. PMID: 17688054.
      View in: PubMed
    65. Wang C, Shiu A, Lii M, Woo S, Chang EL. Automatic target localization and verification for on-line image-guided stereotactic body radiotherapy of the spine. Technol Cancer Res Treat. 2007 Jun; 6(3):187-96. PMID: 17535027.
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    66. Akyurek S, Chang EL, Mahajan A, Hassenbusch SJ, Allen PK, Mathews LA, Shiu AS, Maor MH, Woo SY. Stereotactic radiosurgical treatment of cerebral metastases arising from breast cancer. Am J Clin Oncol. 2007 Jun; 30(3):310-4. PMID: 17551311.
      View in: PubMed
    67. Chang EL, Akyurek S, Avalos T, Rebueno N, Spicer C, Garcia J, Famiglietti R, Allen PK, Chao KS, Mahajan A, Woo SY, Maor MH. Evaluation of peritumoral edema in the delineation of radiotherapy clinical target volumes for glioblastoma. Int J Radiat Oncol Biol Phys. 2007 May 01; 68(1):144-50. PMID: 17306935.
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    68. Chang EL, Wefel JS, Maor MH, Hassenbusch SJ, Mahajan A, Lang FF, Woo SY, Mathews LA, Allen PK, Shiu AS, Meyers CA. A pilot study of neurocognitive function in patients with one to three new brain metastases initially treated with stereotactic radiosurgery alone. Neurosurgery. 2007 Feb; 60(2):277-83; discussion 283-4. PMID: 17290178.
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    69. Hermanto U, Frija EK, Lii MJ, Chang EL, Mahajan A, Woo SY. Intensity-modulated radiotherapy (IMRT) and conventional three-dimensional conformal radiotherapy for high-grade gliomas: does IMRT increase the integral dose to normal brain? Int J Radiat Oncol Biol Phys. 2007 Mar 15; 67(4):1135-44. PMID: 17208388.
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    70. Nguyen QN, Chang EL, Allen PK, Maor MH, Ater JL, Mahajan A, Wolff JE, Weinberg JS, Woo SY. Focal and craniospinal irradiation for patients with intracranial germinoma and patterns of failure. Cancer. 2006 Nov 01; 107(9):2228-36. PMID: 17019739.
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    71. Chang EC, Philips MR. Spatial segregation of Ras signaling: new evidence from fission yeast. Cell Cycle. 2006 Sep; 5(17):1936-9. PMID: 16931912.
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    72. Onken B, Wiener H, Philips MR, Chang EC. Compartmentalized signaling of Ras in fission yeast. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9045-50. PMID: 16754851.
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    73. Hu C, Chang EL, Hassenbusch SJ, Allen PK, Woo SY, Mahajan A, Komaki R, Liao Z. Nonsmall cell lung cancer presenting with synchronous solitary brain metastasis. Cancer. 2006 May 01; 106(9):1998-2004. PMID: 16572401.
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    74. Akyurek S, Chang EL, Yu TK, Little D, Allen PK, McCutcheon I, Mahajan A, Maor MH, Woo SY. Spinal myxopapillary ependymoma outcomes in patients treated with surgery and radiotherapy at M.D. Anderson Cancer Center. J Neurooncol. 2006 Nov; 80(2):177-83. PMID: 16648988.
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    75. Suh JH, Stea B, Nabid A, Kresl JJ, Fortin A, Mercier JP, Senzer N, Chang EL, Boyd AP, Cagnoni PJ, Shaw E. Phase III study of efaproxiral as an adjunct to whole-brain radiation therapy for brain metastases. J Clin Oncol. 2006 Jan 01; 24(1):106-14. PMID: 16314619.
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    76. Lee CT, Bilton SD, Famiglietti RM, Riley BA, Mahajan A, Chang EL, Maor MH, Woo SY, Cox JD, Smith AR. Treatment planning with protons for pediatric retinoblastoma, medulloblastoma, and pelvic sarcoma: how do protons compare with other conformal techniques? Int J Radiat Oncol Biol Phys. 2005 Oct 01; 63(2):362-72. PMID: 16168831.
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    77. Mahajan A, McCutcheon IE, Suki D, Chang EL, Hassenbusch SJ, Weinberg JS, Shiu A, Maor MH, Woo SY. Case-control study of stereotactic radiosurgery for recurrent glioblastoma multiforme. J Neurosurg. 2005 Aug; 103(2):210-7. PMID: 16175848.
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    78. Hutchinson LM, Chang EL, Becker CM, Shih MC, Brice M, DeWolf WC, Gaston SM, Zetter BR. Use of thymosin beta15 as a urinary biomarker in human prostate cancer. Prostate. 2005 Jul 01; 64(2):116-27. PMID: 15666387.
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    79. Lo SS, Chang EL, Suh JH. Stereotactic radiosurgery with and without whole-brain radiotherapy for newly diagnosed brain metastases. Expert Rev Neurother. 2005 Jul; 5(4):487-95. PMID: 16026232.
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    80. Hutchinson LM, Chang EL, Becker CM, Ushiyama N, Behonick D, Shih MC, DeWolf WC, Gaston SM, Zetter BR. Development of a sensitive and specific enzyme-linked immunosorbent assay for thymosin beta15, a urinary biomarker of human prostate cancer. Clin Biochem. 2005 Jun; 38(6):558-71. PMID: 15885237.
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    81. Chang EL, Selek U, Hassenbusch SJ, Maor MH, Allen PK, Mahajan A, Sawaya R, Woo SY. Outcome variation among "radioresistant" brain metastases treated with stereotactic radiosurgery. Neurosurgery. 2005 May; 56(5):936-45; discussion 936-45. PMID: 15854241.
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    82. Pelloski CE, Mahajan A, Maor M, Chang EL, Woo S, Gilbert M, Colman H, Yang H, Ledoux A, Blair H, Passe S, Jenkins RB, Aldape KD. YKL-40 expression is associated with poorer response to radiation and shorter overall survival in glioblastoma. Clin Cancer Res. 2005 May 01; 11(9):3326-34. PMID: 15867231.
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    83. Chang EC, Schwechheimer C. ZOMES III: the interface between signalling and proteolysis. Meeting on The COP9 Signalosome, Proteasome and eIF3. EMBO Rep. 2004 Nov; 5(11):1041-5. PMID: 15514681.
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    84. Chang EL, Shiu AS, Lii MF, Rhines LD, Mendel E, Mahajan A, Weinberg JS, Mathews LA, Brown BW, Maor MH, Cox JD. Phase I clinical evaluation of near-simultaneous computed tomographic image-guided stereotactic body radiotherapy for spinal metastases. Int J Radiat Oncol Biol Phys. 2004 Aug 01; 59(5):1288-94. PMID: 15275711.
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    85. Selek U, Chang EL, Hassenbusch SJ, Shiu AS, Lang FF, Allen P, Weinberg J, Sawaya R, Maor MH. Stereotactic radiosurgical treatment in 103 patients for 153 cerebral melanoma metastases. Int J Radiat Oncol Biol Phys. 2004 Jul 15; 59(4):1097-106. PMID: 15234044.
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    86. Kudchadker RJ, Chang EL, Bryan F, Maor MH, Famiglietti R. An evaluation of radiation exposure from portal films taken during definitive course of pediatric radiotherapy. Int J Radiat Oncol Biol Phys. 2004 Jul 15; 59(4):1229-35. PMID: 15234060.
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    87. Soyuer S, Chang EL, Selek U, McCutcheon IE, Maor MH. Intracranial meningeal hemangiopericytoma: the role of radiotherapy: report of 29 cases and review of the literature. Cancer. 2004 Apr 01; 100(7):1491-7. PMID: 15042684.
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    88. Soyuer S, Chang EL, Selek U, Shi W, Maor MH, DeMonte F. Radiotherapy after surgery for benign cerebral meningioma. Radiother Oncol. 2004 Apr; 71(1):85-90. PMID: 15066300.
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    89. Shiu AS, Chang EL, Ye JS, Lii M, Rhines LD, Mendel E, Weinberg J, Singh S, Maor MH, Mohan R, Cox JD. Near simultaneous computed tomography image-guided stereotactic spinal radiotherapy: an emerging paradigm for achieving true stereotaxy. Int J Radiat Oncol Biol Phys. 2003 Nov 01; 57(3):605-13. PMID: 14529763.
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    90. Li Y, Chang EC. Schizosaccharomyces pombe Ras1 effector, Scd1, interacts with Klp5 and Klp6 kinesins to mediate cytokinesis. Genetics. 2003 Oct; 165(2):477-88. PMID: 14573463.
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    91. Chang EL, Hassenbusch SJ, Shiu AS, Lang FF, Allen PK, Sawaya R, Maor MH. The role of tumor size in the radiosurgical management of patients with ambiguous brain metastases. Neurosurgery. 2003 Aug; 53(2):272-80; discussion 280-1. PMID: 12925241.
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    92. Lee HK, Chang EL, Fuller GN, Aldape KD, Atkinson GJ, Levy LB, McCutcheon IE, Maor MH. The prognostic value of neurologic function in astrocytic spinal cord glioma. Neuro Oncol. 2003 07; 5(3):208-13. PMID: 12816727.
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    93. Yen HC, Espiritu C, Chang EC. Rpn5 is a conserved proteasome subunit and required for proper proteasome localization and assembly. J Biol Chem. 2003 Aug 15; 278(33):30669-76. PMID: 12783882.
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    94. Chang EL, Yi W, Allen PK, Levin VA, Sawaya RE, Maor MH. Hypofractionated radiotherapy for elderly or younger low-performance status glioblastoma patients: outcome and prognostic factors. Int J Radiat Oncol Biol Phys. 2003 Jun 01; 56(2):519-28. PMID: 12738329.
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    95. Yen HC, Chang EC. INT6--a link between the proteasome and tumorigenesis. Cell Cycle. 2003 Mar-Apr; 2(2):81-3. PMID: 12695651.
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    96. Yen HC, Gordon C, Chang EC. Schizosaccharomyces pombe Int6 and Ras homologs regulate cell division and mitotic fidelity via the proteasome. Cell. 2003 Jan 24; 112(2):207-17. PMID: 12553909.
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    97. Chang EL, Maor MH. Standard and novel radiotherapeutic approaches to neoplastic meningitis. Curr Oncol Rep. 2003 Jan; 5(1):24-8. PMID: 12493147.
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    98. Chang EL, Wong PF, Forster KM, Petru MD, Kowalski AV, Maor MH. Verification techniques and dose distribution for computed tomographic planned supine craniospinal radiation therapy. Med Dosim. 2003; 28(2):127-31. PMID: 12804712.
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    99. Chang EL, Lo S. Diagnosis and management of central nervous system metastases from breast cancer. Oncologist. 2003; 8(5):398-410. PMID: 14530493.
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    100. Papadaki P, Pizon V, Onken B, Chang EC. Two ras pathways in fission yeast are differentially regulated by two ras guanine nucleotide exchange factors. Mol Cell Biol. 2002 Jul; 22(13):4598-606. PMID: 12052869.
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    101. Chang EL, Allen P, Wu C, Ater J, Kuttesch J, Maor MH. Acute toxicity and treatment interruption related to electron and photon craniospinal irradiation in pediatric patients treated at the University of Texas M. D. Anderson Cancer Center. Int J Radiat Oncol Biol Phys. 2002 Mar 15; 52(4):1008-16. PMID: 11958896.
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    102. Bandyopadhyay A, Lakshmanan V, Matsumoto T, Chang EC, Maitra U. Moe1 and spInt6, the fission yeast homologues of mammalian translation initiation factor 3 subunits p66 (eIF3d) and p48 (eIF3e), respectively, are required for stable association of eIF3 subunits. J Biol Chem. 2002 Jan 18; 277(3):2360-7. PMID: 11705997.
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    103. Yen HC, Chang EC. Yin6, a fission yeast Int6 homolog, complexes with Moe1 and plays a role in chromosome segregation. Proc Natl Acad Sci U S A. 2000 Dec 19; 97(26):14370-5. PMID: 11121040.
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    104. Chen CR, Chen J, Chang EC. A conserved interaction between Moe1 and Mal3 is important for proper spindle formation in Schizosaccharomyces pombe. Mol Biol Cell. 2000 Dec; 11(12):4067-77. PMID: 11102508.
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    105. Li YC, Chen CR, Chang EC. Fission yeast Ras1 effector Scd1 interacts with the spindle and affects its proper formation. Genetics. 2000 Nov; 156(3):995-1004. PMID: 11063680.
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    106. Chen CR, Li YC, Chen J, Hou MC, Papadaki P, Chang EC. Moe1, a conserved protein in Schizosaccharomyces pombe, interacts with a Ras effector, Scd1, to affect proper spindle formation. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):517-22. PMID: 9892665.
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    107. Marcus S, Polverino A, Chang E, Robbins D, Cobb MH, Wigler MH. Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe. Proc Natl Acad Sci U S A. 1995 Jun 20; 92(13):6180-4. PMID: 7597098.
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    108. Chang EC, Barr M, Wang Y, Jung V, Xu HP, Wigler MH. Cooperative interaction of S. pombe proteins required for mating and morphogenesis. Cell. 1994 Oct 07; 79(1):131-41. PMID: 7923372.
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    109. Andersen LB, Ballester R, Marchuk DA, Chang E, Gutmann DH, Saulino AM, Camonis J, Wigler M, Collins FS. A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity. Mol Cell Biol. 1993 Jan; 13(1):487-95. PMID: 8417346.
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    110. Shibuya EK, Polverino AJ, Chang E, Wigler M, Ruderman JV. Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes. Proc Natl Acad Sci U S A. 1992 Oct 15; 89(20):9831-5. PMID: 1384061.
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    111. Chang EC, Crawford BF, Hong Z, Bilinski T, Kosman DJ. Genetic and biochemical characterization of Cu,Zn superoxide dismutase mutants in Saccharomyces cerevisiae. J Biol Chem. 1991 Mar 05; 266(7):4417-24. PMID: 1999425.
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    112. Chang EC, Kosman DJ. O2-dependent methionine auxotrophy in Cu,Zn superoxide dismutase-deficient mutants of Saccharomyces cerevisiae. J Bacteriol. 1990 Apr; 172(4):1840-5. PMID: 2180907.
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    113. Chang EC, Kosman DJ, Willsky GR. Arsenic oxide-induced thermotolerance in Saccharomyces cerevisiae. J Bacteriol. 1989 Nov; 171(11):6349-52. PMID: 2681165.
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    114. Chang EC, Kosman DJ. Intracellular Mn (II)-associated superoxide scavenging activity protects Cu,Zn superoxide dismutase-deficient Saccharomyces cerevisiae against dioxygen stress. J Biol Chem. 1989 Jul 25; 264(21):12172-8. PMID: 2545701.
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    115. Gralla, E. B., Bermingham-McDonogh, O., Valentine, J. S. Chang, E. C., Frueger, T., Kosman, D. J. . Cloning and Biological Activity of the Cu, Zn SOD gene of S. cerevisiae. UCLA Symp. Mol. Cell. Biol. New Ser. 1988; 82:173-182.
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