TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neurology
Address6501 Fannin St
Houston, TX 77030
vCardDownload vCard
    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Human Genetics
    DivisionMolecular & Human Genetics

    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Neuroscience

    Collapse Affiliation 
    Collapse groups

    Collapse Research 
    Collapse research activities and funding
    K08NS001755     (COOPER, EDWARD C)Aug 1, 1994 - Jul 31, 1999
    Role: Principal Investigator

    R21NS042100     (COOPER, EDWARD C)Sep 15, 2001 - Aug 31, 2005
    Proteomic Dissection of M-channel Phosphorylation
    Role: Principal Investigator

    R01NS049119     (COOPER, EDWARD C)Jul 1, 2004 - Jan 31, 2019
    KCNQ2/3 channels in neonatal-onset epilepsy and encephalopathy
    Role: Principal Investigator

    R21NS055765     (COOPER, EDWARD C)Sep 15, 2006 - Apr 30, 2010
    KCNQ channel opener efficacy for neonatal seizures
    Role: Principal Investigator

    R13NS095592     (COOPER, EDWARD C)Sep 21, 2015 - Sep 20, 2016
    KCNQ2 Epileptic Encephalopathy: Overcoming Hurdles to Effective Disease-Modifying Therapy
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tran B, Ji ZG, Xu M, Tsuchida TN, Cooper EC. Two KCNQ2 Encephalopathy Variants in the Calmodulin-Binding Helix A Exhibit Dominant-Negative Effects and Altered PIP2 Interaction. Front Physiol. 2020; 11:1144. PMID: 33041849.
    2. Miceli F, Carotenuto L, Barrese V, Soldovieri MV, Heinzen EL, Mandel AM, Lippa N, Bier L, Goldstein DB, Cooper EC, Cilio MR, Taglialatela M, Sands TT. A Novel Kv7.3 Variant in the Voltage-Sensing S4 Segment in a Family With Benign Neonatal Epilepsy: Functional Characterization and in vitro Rescue by ß-Hydroxybutyrate. Front Physiol. 2020; 11:1040. PMID: 33013448.
      Citations: 1     
    3. Goto A, Ishii A, Shibata M, Ihara Y, Cooper EC, Hirose S. Characteristics of KCNQ2 variants causing either benign neonatal epilepsy or developmental and epileptic encephalopathy. Epilepsia. 2019 09; 60(9):1870-1880. PMID: 31418850.
      Citations: 13     Fields:    Translation:Humans
    4. Soldovieri MV, Ambrosino P, Mosca I, Miceli F, Franco C, Canzoniero LMT, Kline-Fath B, Cooper EC, Venkatesan C, Taglialatela M. Epileptic Encephalopathy In A Patient With A Novel Variant In The Kv7.2 S2 Transmembrane Segment: Clinical, Genetic, and Functional Features. Int J Mol Sci. 2019 Jul 10; 20(14). PMID: 31295832.
      Citations: 5     Fields:    Translation:HumansCells
    5. Sands TT, Miceli F, Lesca G, Beck AE, Sadleir LG, Arrington DK, Schönewolf-Greulich B, Moutton S, Lauritano A, Nappi P, Soldovieri MV, Scheffer IE, Mefford HC, Stong N, Heinzen EL, Goldstein DB, Perez AG, Kossoff EH, Stocco A, Sullivan JA, Shashi V, Gerard B, Francannet C, Bisgaard AM, Tümer Z, Willems M, Rivier F, Vitobello A, Thakkar K, Rajan DS, Barkovich AJ, Weckhuysen S, Cooper EC, Taglialatela M, Cilio MR. Autism and developmental disability caused by KCNQ3 gain-of-function variants. Ann Neurol. 2019 08; 86(2):181-192. PMID: 31177578.
      Citations: 14     Fields:    Translation:HumansCells
    6. Mulkey SB, Ben-Zeev B, Nicolai J, Carroll JL, Grønborg S, Jiang YH, Joshi N, Kelly M, Koolen DA, Mikati MA, Park K, Pearl PL, Scheffer IE, Spillmann RC, Taglialatela M, Vieker S, Weckhuysen S, Cooper EC, Cilio MR. Neonatal nonepileptic myoclonus is a prominent clinical feature of KCNQ2 gain-of-function variants R201C and R201H. Epilepsia. 2017 03; 58(3):436-445. PMID: 28139826.
      Citations: 19     Fields:    Translation:Humans
    7. Millichap JJ, Miceli F, De Maria M, Keator C, Joshi N, Tran B, Soldovieri MV, Ambrosino P, Shashi V, Mikati MA, Cooper EC, Taglialatela M. Infantile spasms and encephalopathy without preceding neonatal seizures caused by KCNQ2 R198Q, a gain-of-function variant. Epilepsia. 2017 01; 58(1):e10-e15. PMID: 27861786.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    8. Millichap JJ, Park KL, Tsuchida T, Ben-Zeev B, Carmant L, Flamini R, Joshi N, Levisohn PM, Marsh E, Nangia S, Narayanan V, Ortiz-Gonzalez XR, Patterson MC, Pearl PL, Porter B, Ramsey K, McGinnis EL, Taglialatela M, Tracy M, Tran B, Venkatesan C, Weckhuysen S, Cooper EC. KCNQ2 encephalopathy: Features, mutational hot spots, and ezogabine treatment of 11 patients. Neurol Genet. 2016 Oct; 2(5):e96. PMID: 27602407.
      Citations: 46     
    9. Xu M, Cooper EC. An Ankyrin-G N-terminal Gate and Protein Kinase CK2 Dually Regulate Binding of Voltage-gated Sodium and KCNQ2/3 Potassium Channels. J Biol Chem. 2015 Jul 03; 290(27):16619-32. PMID: 25998125.
      Citations: 25     Fields:    Translation:HumansCells
    10. Hirst CS, Foong JP, Stamp LA, Fegan E, Dent S, Cooper EC, Lomax AE, Anderson CR, Bornstein JC, Young HM, McKeown SJ. Ion channel expression in the developing enteric nervous system. PLoS One. 2015; 10(3):e0123436. PMID: 25798587.
      Citations: 4     Fields:    Translation:AnimalsCells
    11. Martinello K, Huang Z, Lujan R, Tran B, Watanabe M, Cooper EC, Brown DA, Shah MM. Cholinergic afferent stimulation induces axonal function plasticity in adult hippocampal granule cells. Neuron. 2015 Jan 21; 85(2):346-63. PMID: 25578363.
      Citations: 40     Fields:    Translation:AnimalsCells
    12. Chang KJ, Zollinger DR, Susuki K, Sherman DL, Makara MA, Brophy PJ, Cooper EC, Bennett V, Mohler PJ, Rasband MN. Glial ankyrins facilitate paranodal axoglial junction assembly. Nat Neurosci. 2014 Dec; 17(12):1673-81. PMID: 25362471.
      Citations: 39     Fields:    Translation:AnimalsCells
    13. Ho TS, Zollinger DR, Chang KJ, Xu M, Cooper EC, Stankewich MC, Bennett V, Rasband MN. A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier. Nat Neurosci. 2014 Dec; 17(12):1664-72. PMID: 25362473.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    14. Kang S, Xu M, Cooper EC, Hoshi N. Channel-anchored protein kinase CK2 and protein phosphatase 1 reciprocally regulate KCNQ2-containing M-channels via phosphorylation of calmodulin. J Biol Chem. 2014 Apr 18; 289(16):11536-11544. PMID: 24627475.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    15. Battefeld A, Tran BT, Gavrilis J, Cooper EC, Kole MH. Heteromeric Kv7.2/7.3 channels differentially regulate action potential initiation and conduction in neocortical myelinated axons. J Neurosci. 2014 Mar 05; 34(10):3719-32. PMID: 24599470.
      Citations: 67     Fields:    Translation:AnimalsCells
    16. Kole MH, Cooper EC. Axonal Kv7.2/7.3 channels: caught in the act. Channels (Austin). 2014; 8(4):288-9. PMID: 25171180.
      Citations: 2     Fields:    Translation:AnimalsCells
    17. Cooper EA, Edelman JJ, Black D, Brereton RJ, Ross DE, Bannon PG, Wilson MK, Vallely MP. Anaortic off-pump coronary artery bypass grafting in the elderly and very elderly. Heart Lung Circ. 2013 Dec; 22(12):989-95. PMID: 23827207.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    18. Millichap JJ, Cooper EC. KCNQ2 Potassium Channel Epileptic Encephalopathy Syndrome: Divorce of an Electro-Mechanical Couple? Epilepsy Curr. 2012 Jul; 12(4):150-2. PMID: 22936888.
      Citations: 8     
    19. Cooper EC. Made for "anchorin": Kv7.2/7.3 (KCNQ2/KCNQ3) channels and the modulation of neuronal excitability in vertebrate axons. Semin Cell Dev Biol. 2011 Apr; 22(2):185-92. PMID: 20940059.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    20. Cooper EC. The cadherin superfamily and epileptogenesis: end of the beginning? Epilepsy Curr. 2009 May-Jun; 9(3):87-9. PMID: 19471581.
    21. Raol YH, Lapides DA, Keating JG, Brooks-Kayal AR, Cooper EC. A KCNQ channel opener for experimental neonatal seizures and status epilepticus. Ann Neurol. 2009 Mar; 65(3):326-36. PMID: 19334075.
      Citations: 25     Fields:    Translation:Animals
    22. Hill AS, Nishino A, Nakajo K, Zhang G, Fineman JR, Selzer ME, Okamura Y, Cooper EC. Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates. PLoS Genet. 2008 Dec; 4(12):e1000317. PMID: 19112491.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    23. Jin Z, Liang GH, Cooper EC, Jarlebark L. Expression and localization of K channels KCNQ2 and KCNQ3 in the mammalian cochlea. Audiol Neurootol. 2009; 14(2):98-105. PMID: 18827480.
      Citations: 8     Fields:    Translation:AnimalsCells
    24. Cooper EC. Funny team member makes key plays, but leaves the dendritic field when hit hard. Epilepsy Curr. 2008 Jul-Aug; 8(4):103-5. PMID: 18596878.
    25. Shah MM, Migliore M, Valencia I, Cooper EC, Brown DA. Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons. Proc Natl Acad Sci U S A. 2008 Jun 03; 105(22):7869-74. PMID: 18515424.
      Citations: 128     Fields:    Translation:AnimalsCells
    26. Cooper EC, Pan Z. Putting an end to DEND: a severe neonatal-onset epilepsy is treatable if recognized early. Neurology. 2007 Sep 25; 69(13):1310-1. PMID: 17893291.
      Citations: 1     Fields:    Translation:HumansCells
    27. Kuramoto N, Wilkins ME, Fairfax BP, Revilla-Sanchez R, Terunuma M, Tamaki K, Iemata M, Warren N, Couve A, Calver A, Horvath Z, Freeman K, Carling D, Huang L, Gonzales C, Cooper E, Smart TG, Pangalos MN, Moss SJ. Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinase. Neuron. 2007 Jan 18; 53(2):233-47. PMID: 17224405.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    28. Cooper EC. (What to do) when epilepsy gene mutations stop making sense. Epilepsy Curr. 2007 Jan-Feb; 7(1):23-5. PMID: 17304347.
    29. Cooper EC. Exploiting the other inhibitory ion: KCNQ potassium channels and regulation of excitability in developing and mature brain. Epilepsy Curr. 2006 Jul-Aug; 6(4):133-5. PMID: 17260036.
    30. Schwarz JR, Glassmeier G, Cooper EC, Kao TC, Nodera H, Tabuena D, Kaji R, Bostock H. KCNQ channels mediate IKs, a slow K+ current regulating excitability in the rat node of Ranvier. J Physiol. 2006 May 15; 573(Pt 1):17-34. PMID: 16527853.
      Citations: 96     Fields:    Translation:AnimalsCells
    31. Pan Z, Kao T, Horvath Z, Lemos J, Sul JY, Cranstoun SD, Bennett V, Scherer SS, Cooper EC. A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon. J Neurosci. 2006 Mar 08; 26(10):2599-613. PMID: 16525039.
      Citations: 245     Fields:    Translation:HumansAnimalsCells
    32. Surti TS, Huang L, Jan YN, Jan LY, Cooper EC. Identification by mass spectrometry and functional characterization of two phosphorylation sites of KCNQ2/KCNQ3 channels. Proc Natl Acad Sci U S A. 2005 Dec 06; 102(49):17828-33. PMID: 16319223.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    33. Cooper EC, Baraban SC. Pain without gain (of function): sodium channel dysfunction in epilepsy. Epilepsy Curr. 2004 Jul-Aug; 4(4):158-9. PMID: 16059485.
    34. Devaux JJ, Kleopa KA, Cooper EC, Scherer SS. KCNQ2 is a nodal K+ channel. J Neurosci. 2004 Feb 04; 24(5):1236-44. PMID: 14762142.
      Citations: 170     Fields:    Translation:HumansAnimalsCells
    35. Tsao JW, Cooper EC. Reflex-sensitive spinal segmental myoclonus associated with vitamin B12 deficiency. Neurology. 2003 Sep 23; 61(6):867-8. PMID: 14504348.
      Citations: 2     Fields:    Translation:Humans
    36. Cooper EC, Jan LY. M-channels: neurological diseases, neuromodulation, and drug development. Arch Neurol. 2003 Apr; 60(4):496-500. PMID: 12707061.
      Citations: 44     Fields:    Translation:Humans
    37. Cooper EC, Harrington E, Jan YN, Jan LY. M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain. J Neurosci. 2001 Dec 15; 21(24):9529-40. PMID: 11739564.
      Citations: 110     Fields:    Translation:HumansAnimalsCells
    38. Castro PA, Cooper EC, Lowenstein DH, Baraban SC. Hippocampal heterotopia lack functional Kv4.2 potassium channels in the methylazoxymethanol model of cortical malformations and epilepsy. J Neurosci. 2001 Sep 01; 21(17):6626-34. PMID: 11517252.
      Citations: 35     Fields:    Translation:AnimalsCells
    39. Cooper EC. Potassium channels: how genetic studies of epileptic syndromes open paths to new therapeutic targets and drugs. Epilepsia. 2001; 42 Suppl 5:49-54. PMID: 11887968.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    40. Cooper EC, Aldape KD, Abosch A, Barbaro NM, Berger MS, Peacock WS, Jan YN, Jan LY. Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy. Proc Natl Acad Sci U S A. 2000 Apr 25; 97(9):4914-9. PMID: 10781098.
      Citations: 58     Fields:    Translation:HumansCells
    41. Cooper EC, Jan LY. Ion channel genes and human neurological disease: recent progress, prospects, and challenges. Proc Natl Acad Sci U S A. 1999 Apr 27; 96(9):4759-66. PMID: 10220366.
      Citations: 29     Fields:    Translation:HumansCells
    42. Gleeson JG, Minnerath SR, Fox JW, Allen KM, Luo RF, Hong SE, Berg MJ, Kuzniecky R, Reitnauer PJ, Borgatti R, Mira AP, Guerrini R, Holmes GL, Rooney CM, Berkovic S, Scheffer I, Cooper EC, Ricci S, Cusmai R, Crawford TO, Leroy R, Andermann E, Wheless JW, Dobyns WB, Walsh CA, et al. Characterization of mutations in the gene doublecortin in patients with double cortex syndrome. Ann Neurol. 1999 Feb; 45(2):146-53. PMID: 9989615.
      Citations: 37     Fields:    Translation:HumansCells
    43. Brenman JE, Topinka JR, Cooper EC, McGee AW, Rosen J, Milroy T, Ralston HJ, Bredt DS. Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. J Neurosci. 1998 Nov 01; 18(21):8805-13. PMID: 9786987.
      Citations: 49     Fields:    Translation:AnimalsCells
    44. Cooper EC, Milroy A, Jan YN, Jan LY, Lowenstein DH. Presynaptic localization of Kv1.4-containing A-type potassium channels near excitatory synapses in the hippocampus. J Neurosci. 1998 Feb 01; 18(3):965-74. PMID: 9437018.
      Citations: 45     Fields:    Translation:AnimalsCells
    45. Gleeson JG, Allen KM, Fox JW, Lamperti ED, Berkovic S, Scheffer I, Cooper EC, Dobyns WB, Minnerath SR, Ross ME, Walsh CA. Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein. Cell. 1998 Jan 09; 92(1):63-72. PMID: 9489700.
      Citations: 260     Fields:    Translation:HumansCells
    46. Agnew WS, Cooper EC, Shenkel S, Correa AM, James WM, Ukomadu C, Tomiko SA. Voltage-sensitive sodium channels: agents that perturb inactivation gating. Ann N Y Acad Sci. 1991; 625:200-23. PMID: 1647724.
      Citations: 2     Fields:    Translation:AnimalsCells
    47. Shenkel S, Cooper EC, James W, Agnew WS, Sigworth FJ. Purified, modified eel sodium channels are active in planar bilayers in the absence of activating neurotoxins. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9592-6. PMID: 2556720.
      Citations: 7     Fields:    Translation:Animals
    48. Cooper EC, Agnew WS. Reconstituted voltage-sensitive sodium channels from eel electroplax: activation of permeability by quaternary lidocaine, N-bromoacetamide, and N-bromosuccinimide. J Membr Biol. 1989 Nov; 111(3):253-64. PMID: 2557451.
      Citations:    Fields:    Translation:Animals
    49. Cooper EC, Tomiko SA, Agnew WS. Reconstituted voltage-sensitive sodium channel from Electrophorus electricus: chemical modifications that alter regulation of ion permeability. Proc Natl Acad Sci U S A. 1987 Sep; 84(17):6282-6. PMID: 2442755.
      Citations: 7     Fields:    Translation:Animals
    50. Greenberg DA, Cooper EC, Carpenter CL. Reversible dihydropyridine isothiocyanate binding to brain calcium channels. J Neurochem. 1985 Jan; 44(1):319-21. PMID: 2578060.
      Citations:    Fields:    Translation:Animals
    51. Greenberg DA, Cooper EC, Carpenter CL. Phenytoin interacts with calcium channels in brain membranes. Ann Neurol. 1984 Nov; 16(5):616-7. PMID: 6095733.
      Citations: 2     Fields:    Translation:Animals
    52. Greenberg DA, Cooper EC. Effect of ethanol on [3H]nitrendipine binding to calcium channels in brain membranes. Alcohol Clin Exp Res. 1984 Nov-Dec; 8(6):568-71. PMID: 6097136.
      Citations: 1     Fields:    Translation:Animals
    53. Greenberg DA, Cooper EC, Carpenter CL. Calcium entry activators: distinct sites of dihydropyridine and aminopyridine action. Neurosci Lett. 1984 Sep 07; 50(1-3):279-82. PMID: 6208517.
      Citations:    Fields:    Translation:Animals
    54. Greenberg DA, Cooper EC, Carpenter CL. Calcium channel 'agonist' BAY K 8644 inhibits calcium antagonist binding to brain and PC12 cell membranes. Brain Res. 1984 Jul 09; 305(2):365-8. PMID: 6204725.
      Citations: 6     Fields:    Translation:AnimalsCells
    COOPER's Networks
    Click the
    buttons for more information and interactive visualizations!
    Concepts (317)
    Co-Authors (2)
    Similar People (60)
    Same Department Expand Description
    Physical Neighbors