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DOBROMIR DOBREV

TitleAdjunct Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Physiology & Biophysics
DivisionMolecular Physiology & Biophysics
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dobrev D, Aguilar M, Heijman J, Guichard JB, Nattel S. Postoperative atrial fibrillation: mechanisms, manifestations and management. Nat Rev Cardiol. 2019 Jul; 16(7):417-436. PMID: 30792496.
      View in: PubMed
    2. Alsina KM, Hulsurkar M, Brandenburg S, Kownatzki-Danger D, Lenz C, Urlaub H, Abu-Taha I, Kamler M, Chiang DY, Lahiri SK, Reynolds JO, Quick AP, Scott L, Word TA, Gelves MD, Heck AJR, Li N, Dobrev D, Lehnart SE, Wehrens XHT. Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation. Circulation. 2019 Jun 12. PMID: 31185731.
      View in: PubMed
    3. Fender AC, Dobrev D. Anticoagulation in difficult settings RELOADed: Evidence for applicability of direct oral anticoagulants in patients with atrial fibrillation, renal impairment and cancer. Int J Cardiol Heart Vasc. 2019 Jun; 23:100374. PMID: 31193086.
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    4. Wakili R, Riesinger L, Fender AC, Dobrev D. Double Jeopardy: Will the new trials tell us how to manage patients with atrial fibrillation and coronary artery disease? Int J Cardiol Heart Vasc. 2019 Jun; 23:100369. PMID: 31111088.
      View in: PubMed
    5. Fender AC, Wakili R, Dobrev D. Straight to the heart: Pleiotropic antiarrhythmic actions of oral anticoagulants. Pharmacol Res. 2019 Jul; 145:104257. PMID: 31054953.
      View in: PubMed
    6. Linz D, Dobrev D. Outcome of atrial fibrillation ablation in pulmonary hypertension: Is pulmonary hypertension a modifiable risk factor? Int J Cardiol Heart Vasc. 2019 Jun; 23:100360. PMID: 31016225.
      View in: PubMed
    7. Fender AC, Dobrev D. Bound to bleed: How altered albumin binding may dictate warfarin treatment outcome. Int J Cardiol Heart Vasc. 2019 Mar; 22:214-215. PMID: 30963099.
      View in: PubMed
    8. Linz D, Sanders P, Pitman B, Dobrev D, Lau DH. Atrial fibrillation in sub-Saharan Africa: The knowns and unknowns? Int J Cardiol Heart Vasc. 2019 Mar; 22:212-213. PMID: 30963098.
      View in: PubMed
    9. Barefield DY, McNamara JW, Lynch TL, Kuster DWD, Govindan S, Haar L, Wang Y, Taylor EN, Lorenz JN, Nieman ML, Zhu G, Luther PK, Varró A, Dobrev D, Ai X, Janssen PML, Kass DA, Jones WK, Gilbert RJ, Sadayappan S. Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury. J Mol Cell Cardiol. 2019 Apr; 129:236-246. PMID: 30862451.
      View in: PubMed
    10. Heijman J, Dobrev D. Bayesian network analyses in atrial fibrillation - A path to better therapies? Int J Cardiol Heart Vasc. 2019 Mar; 22:210-211. PMID: 30963097.
      View in: PubMed
    11. Dobrev D. Atrial Ca2+/calmodulin-dependent protein kinase II: A druggable master switch of atrial fibrillation-associated atrial remodeling? Heart Rhythm. 2019 Jul; 16(7):1089-1090. PMID: 30735791.
      View in: PubMed
    12. Grandi E, Dobrev D, Heijman J. Computational modeling: What does it tell us about atrial fibrillation therapy? Int J Cardiol. 2019 Jul 15; 287:155-161. PMID: 30803891.
      View in: PubMed
    13. Belau F, Metzner K, Christ T, Ravens U, Schaefer M, Künzel S, Li W, Wettwer E, Dobrev D, El-Armouche A, Kämmerer S. DPP10 is a new regulator of Nav1.5 channels in human heart. Int J Cardiol. 2019 Jun 01; 284:68-73. PMID: 30638748.
      View in: PubMed
    14. Linz D, Elliott AD, Hohl M, Malik V, Schotten U, Dobrev D, Nattel S, Böhm M, Floras J, Lau DH, Sanders P. Role of autonomic nervous system in atrial fibrillation. Int J Cardiol. 2019 Jul 15; 287:181-188. PMID: 30497894.
      View in: PubMed
    15. Yao C, Veleva T, Scott L, Cao S, Li L, Chen G, Jeyabal P, Pan X, Alsina KM, Abu-Taha I, Ghezelbash S, Reynolds CL, Shen YH, LeMaire SA, Schmitz W, Müller FU, El-Armouche A, Tony Eissa N, Beeton C, Nattel S, Wehrens XHT, Dobrev D, Li N. Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation. Circulation. 2018 Nov 13; 138(20):2227-2242. PMID: 29802206.
      View in: PubMed
    16. Tsuji Y, Dobrev D. Electrical storm: mechanistic and therapeutic considerations to avoid death in the survivors. J Thorac Dis. 2018 Nov; 10(Suppl 33):S4053-S4056. PMID: 30631553.
      View in: PubMed
    17. Molina CE, Abu-Taha IH, Wang Q, Roselló-Díez E, Kamler M, Nattel S, Ravens U, Wehrens XHT, Hove-Madsen L, Heijman J, Dobrev D. Profibrotic, Electrical, and Calcium-Handling Remodeling of the Atria in Heart Failure Patients With and Without Atrial Fibrillation. Front Physiol. 2018; 9:1383. PMID: 30356673.
      View in: PubMed
    18. Scott L, Li N, Dobrev D. Role of inflammatory signaling in atrial fibrillation. Int J Cardiol. 2019 Jul 15; 287:195-200. PMID: 30316645.
      View in: PubMed
    19. Sutanto H, Dobrev D, Heijman J. Resveratrol: an effective pharmacological agent to prevent inflammation-induced atrial fibrillation? Naunyn Schmiedebergs Arch Pharmacol. 2018 11; 391(11):1163-1167. PMID: 30238135.
      View in: PubMed
    20. Dobrev D, Fender AC, Wehrens XHT. Pro-arrhythmic RyR2 channels in heart failure: do their localisation and mechanism of activation really matter? Cardiovasc Res. 2018 Sep 01; 114(11):1428-1429. PMID: 29982290.
      View in: PubMed
    21. Heijman J, Dobrev D, Crijns HJGM. Electrocardiographic characteristics associated with atrial fibrillation - What do they tell us? Int J Cardiol. 2018 09 01; 266:143-144. PMID: 29887430.
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    22. Chen G, Chelu MG, Dobrev D, Li N. Cardiomyocyte Inflammasome Signaling in Cardiomyopathies and Atrial Fibrillation: Mechanisms and Potential Therapeutic Implications. Front Physiol. 2018; 9:1115. PMID: 30150941.
      View in: PubMed
    23. Dobrev D, Wehrens XHT. Mouse Models of Cardiac Arrhythmias. Circ Res. 2018 Jul 20; 123(3):332-334. PMID: 30026380.
      View in: PubMed
    24. Dobrev D. Sex-specific density of ventricular SK currents: is this a general feature of SK channel function? J Physiol. 2018 Jul 18. PMID: 30019760.
      View in: PubMed
    25. Fender AC, Dobrev D. Switching off the jitters: Dabigatran as a candidate approach to halt atrial fibrillation? Int J Cardiol. 2018 11 15; 271:254-255. PMID: 29958692.
      View in: PubMed
    26. Linz D, Hohl M, Dobrev D. Can cystatin C-based estimated glomerular filtration rate help to guide individualized risk factor modification programs? Int J Cardiol Heart Vasc. 2018 Jun; 19:100-101. PMID: 29955670.
      View in: PubMed
    27. Fender AC, Dobrev D. The not-so-sweet problem of hearts aflutter: Dissecting stroke risk in atrial fibrillation with concomitant diabetes. Int J Cardiol. 2018 10 01; 268:153-154. PMID: 29804702.
      View in: PubMed
    28. Dobrev D, Lorenz K. Age-dependent increase in c-Jun N-terminal kinase-2 activity: does this help to understand Ca2+-calmodulin-dependent protein-kinase II-mediated atrial arrhythmogenesis in human atrial fibrillation? Cardiovasc Res. 2018 04 01; 114(5):641-642. PMID: 29432608.
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    29. Tsuji Y, Dobrev D. Prognostic impact of electrical storm in patients with implantable cardioverter defibrillators: Mechanistic and therapeutic considerations to reduce the risk of death. Int J Cardiol. 2018 03 15; 255:101-102. PMID: 29425546.
      View in: PubMed
    30. Heijman J, Guichard JB, Dobrev D, Nattel S. Translational Challenges in Atrial Fibrillation. Circ Res. 2018 Mar 02; 122(5):752-773. PMID: 29496798.
      View in: PubMed
    31. Kotecha D, Breithardt G, Camm AJ, Lip GYH, Schotten U, Ahlsson A, Arnar D, Atar D, Auricchio A, Bax J, Benussi S, Blomstrom-Lundqvist C, Borggrefe M, Boriani G, Brandes A, Calkins H, Casadei B, Castellá M, Chua W, Crijns H, Dobrev D, Fabritz L, Feuring M, Freedman B, Gerth A, Goette A, Guasch E, Haase D, Hatem S, Haeusler KG, Heidbuchel H, Hendriks J, Hunter C, Kääb S, Kespohl S, Landmesser U, Lane DA, Lewalter T, Mont L, Nabauer M, Nielsen JC, Oeff M, Oldgren J, Oto A, Pison L, Potpara T, Ravens U, Richard-Lordereau I, Rienstra M, Savelieva I, Schnabel R, Sinner MF, Sommer P, Themistoclakis S, Van Gelder IC, Vardas PE, Verma A, Wakili R, Weber E, Werring D, Willems S, Ziegler A, Hindricks G, Kirchhof P. Integrating new approaches to atrial fibrillation management: the 6th AFNET/EHRA Consensus Conference. Europace. 2018 03 01; 20(3):395-407. PMID: 29300976.
      View in: PubMed
    32. Molina CE, Jacquet E, Ponien P, Muñoz-Guijosa C, Baczkó I, Maier LS, Donzeau-Gouge P, Dobrev D, Fischmeister R, Garnier A. Identification of optimal reference genes for transcriptomic analyses in normal and diseased human heart. Cardiovasc Res. 2018 02 01; 114(2):247-258. PMID: 29036603.
      View in: PubMed
    33. Li N, Dobrev D. Targeting atrial fibrillation promoting atrial structural remodeling: is this a viable strategy in patients with heart failure? Naunyn Schmiedebergs Arch Pharmacol. 2018 03; 391(3):231-233. PMID: 29327256.
      View in: PubMed
    34. Heijman J, Kirchner D, Kunze F, Chrétien EM, Michel-Reher MB, Voigt N, Knaut M, Michel MC, Ravens U, Dobrev D. Muscarinic type-1 receptors contribute to IK,ACh in human atrial cardiomyocytes and are upregulated in patients with chronic atrial fibrillation. Int J Cardiol. 2018 Mar 15; 255:61-68. PMID: 29290419.
      View in: PubMed
    35. Wakili R, Dobrev D. Response to: "The emerging role of hybrid ablation for ablation" by Spartialis M. et al. Int J Cardiol. 2017 12 15; 249:258. PMID: 29121728.
      View in: PubMed
    36. Heijman J, Dobrev D. Ion channels as part of macromolecular multiprotein complexes : Clinical significance. Herzschrittmacherther Elektrophysiol. 2018 Mar; 29(1):30-35. PMID: 29214349.
      View in: PubMed
    37. Ellinwood N, Dobrev D, Morotti S, Grandi E. In Silico Assessment of Efficacy and Safety of IKur Inhibitors in Chronic Atrial Fibrillation: Role of Kinetics and State-Dependence of Drug Binding. Front Pharmacol. 2017; 8:799. PMID: 29163179.
      View in: PubMed
    38. Grandi E, Dobrev D. Non-ion channel therapeutics for heart failure and atrial fibrillation: Are CaMKII inhibitors ready for clinical use? J Mol Cell Cardiol. 2018 08; 121:300-303. PMID: 29079077.
      View in: PubMed
    39. Abu-Taha IH, Heijman J, Feng Y, Vettel C, Dobrev D, Wieland T. Regulation of heterotrimeric G-protein signaling by NDPK/NME proteins and caveolins: an update. Lab Invest. 2018 02; 98(2):190-197. PMID: 29035382.
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    40. Heijman J, Dobrev D. Inhibition of Small-Conductance Ca2+-Activated K+ Channels: The Long-Awaited Breakthrough for Antiarrhythmic Drug Therapy of Atrial Fibrillation? Circ Arrhythm Electrophysiol. 2017 10; 10(10). PMID: 29018167.
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    41. Ellinwood N, Dobrev D, Morotti S, Grandi E. Erratum: "Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity" [Chaos 27, 093918 (2017)]. Chaos. 2017 10; 27(10):109902. PMID: 29092428.
      View in: PubMed
    42. Heijman J, Dobrev D, Crijns HJGM. Targeting supraventricular ectopic complexes: Which approach should be used and how does it affect atrial fibrillation? Int J Cardiol. 2017 10 01; 244:202-203. PMID: 28784443.
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    43. Fender AC, Dobrev D. Dynamic balance of platelet reactivity in atrial fibrillation PARtially unravelled. Int J Cardiol. 2017 09 15; 243:272-273. PMID: 28747029.
      View in: PubMed
    44. Wakili R, Dobrev D. Role of triggers and substrate in heart failure based atrial fibrillation: Is pulmonary vein isolation still the cornerstone of atrial fibrillation therapy? Int J Cardiol. 2017 09 15; 243:276-278. PMID: 28747031.
      View in: PubMed
    45. Meyer-Roxlau S, Lämmle S, Opitz A, Künzel S, Joos JP, Neef S, Sekeres K, Sossalla S, Schöndube F, Alexiou K, Maier LS, Dobrev D, Guan K, Weber S, El-Armouche A. Erratum to: Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation. Basic Res Cardiol. 2017 09; 112(5):51. PMID: 28688054.
      View in: PubMed
    46. Ellinwood N, Dobrev D, Morotti S, Grandi E. Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity. Chaos. 2017 Sep; 27(9):093918. PMID: 28964116.
      View in: PubMed
    47. Heijman J, Ghezelbash S, Dobrev D. Investigational antiarrhythmic agents: promising drugs in early clinical development. Expert Opin Investig Drugs. 2017 Aug; 26(8):897-907. PMID: 28691539.
      View in: PubMed
    48. Ji Y, Varkevisser R, Opacic D, Bossu A, Kuiper M, Beekman JDM, Yang S, Khan AP, Dobrev D, Voigt N, Wang MZ, Verheule S, Vos MA, van der Heyden MAG. The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. Br J Pharmacol. 2017 08; 174(15):2576-2590. PMID: 28542844.
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    49. Landstrom AP, Dobrev D, Wehrens XHT. Calcium Signaling and Cardiac Arrhythmias. Circ Res. 2017 Jun 09; 120(12):1969-1993. PMID: 28596175.
      View in: PubMed
    50. Meyer-Roxlau S, Lämmle S, Opitz A, Künzel S, Joos JP, Neef S, Sekeres K, Sossalla S, Schöndube F, Alexiou K, Maier LS, Dobrev D, Guan K, Weber S, El-Armouche A. Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation. Basic Res Cardiol. 2017 07; 112(4):43. PMID: 28597249.
      View in: PubMed
    51. Schmidt C, Wiedmann F, Zhou XB, Heijman J, Voigt N, Ratte A, Lang S, Kallenberger SM, Campana C, Weymann A, De Simone R, Szabo G, Ruhparwar A, Kallenbach K, Karck M, Ehrlich JR, Baczkó I, Borggrefe M, Ravens U, Dobrev D, Katus HA, Thomas D. Inverse remodelling of K2P3.1 K+ channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy. Eur Heart J. 2017 Jun 07; 38(22):1764-1774. PMID: 28057773.
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    52. Nattel S, Dobrev D. Controversies About Atrial Fibrillation Mechanisms: Aiming for Order in Chaos and Whether it Matters. Circ Res. 2017 04 28; 120(9):1396-1398. PMID: 28450363.
      View in: PubMed
    53. Neef S, Heijman J, Otte K, Dewenter M, Saadatmand AR, Meyer-Roxlau S, Antos CL, Backs J, Dobrev D, Wagner M, Maier LS, El-Armouche A. Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity. Naunyn Schmiedebergs Arch Pharmacol. 2017 Aug; 390(8):857-862. PMID: 28451724.
      View in: PubMed
    54. Dobrev D, Wehrens XHT. Calcium-mediated cellular triggered activity in atrial fibrillation. J Physiol. 2017 06 15; 595(12):4001-4008. PMID: 28181690.
      View in: PubMed
    55. Chen Y, Surinkaew S, Naud P, Qi XY, Gillis MA, Shi YF, Tardif JC, Dobrev D, Nattel S. JAK-STAT signalling and the atrial fibrillation promoting fibrotic substrate. Cardiovasc Res. 2017 Mar 01; 113(3):310-320. PMID: 28158495.
      View in: PubMed
    56. Heijman J, Ghezelbash S, Wehrens XH, Dobrev D. Serine/Threonine Phosphatases in Atrial Fibrillation. J Mol Cell Cardiol. 2017 02; 103:110-120. PMID: 28077320.
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    57. Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM. Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics. J Physiol. 2017 04 01; 595(7):2229-2252. PMID: 27808412.
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    58. Abu-Taha IH, Heijman J, Hippe HJ, Wolf NM, El-Armouche A, Nikolaev VO, Schäfer M, Würtz CM, Neef S, Voigt N, Baczkó I, Varró A, Müller M, Meder B, Katus HA, Spiger K, Vettel C, Lehmann LH, Backs J, Skolnik EY, Lutz S, Dobrev D, Wieland T. Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure. Circulation. 2017 Feb 28; 135(9):881-897. PMID: 27927712.
      View in: PubMed
    59. Li N, Dobrev D. Hyperuricemia: A causal player or a bystander linking inflammatory signaling and atrial fibrillation? Int J Cardiol. 2017 Mar 15; 231:177-178. PMID: 27993379.
      View in: PubMed
    60. Dobrev D. Unique cardiomyocyte ultrastructure in atria: Role of T tubules in subcellular Ca2+ signaling and atrial arrhythmogenesis. Heart Rhythm. 2017 02; 14(2):282-283. PMID: 27756707.
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    61. Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, Castella M, Diener HC, Heidbuchel H, Hendriks J, Hindricks G, Manolis AS, Oldgren J, Popescu BA, Schotten U, Van Putte B, Vardas P, Agewall S, Camm J, Baron Esquivias G, Budts W, Carerj S, Casselman F, Coca A, De Caterina R, Deftereos S, Dobrev D, Ferro JM, Filippatos G, Fitzsimons D, Gorenek B, Guenoun M, Hohnloser SH, Kolh P, Lip GY, Manolis A, McMurray J, Ponikowski P, Rosenhek R, Ruschitzka F, Savelieva I, Sharma S, Suwalski P, Tamargo JL, Taylor CJ, Van Gelder IC, Voors AA, Windecker S, Zamorano JL, Zeppenfeld K. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur J Cardiothorac Surg. 2016 Nov; 50(5):e1-e88. PMID: 27663299.
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    62. Chiang DY, Heck AJ, Dobrev D, Wehrens XH. Regulating the regulator: Insights into the cardiac protein phosphatase 1 interactome. J Mol Cell Cardiol. 2016 Dec; 101:165-172. PMID: 27663175.
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    63. Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, Castella M, Diener HC, Heidbuchel H, Hendriks J, Hindricks G, Manolis AS, Oldgren J, Popescu BA, Schotten U, Van Putte B, Vardas P, Agewall S, Camm J, Baron Esquivias G, Budts W, Carerj S, Casselman F, Coca A, De Caterina R, Deftereos S, Dobrev D, Ferro JM, Filippatos G, Fitzsimons D, Gorenek B, Guenoun M, Hohnloser SH, Kolh P, Lip GY, Manolis A, McMurray J, Ponikowski P, Rosenhek R, Ruschitzka F, Savelieva I, Sharma S, Suwalski P, Tamargo JL, Taylor CJ, Van Gelder IC, Voors AA, Windecker S, Zamorano JL, Zeppenfeld K. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Europace. 2016 Nov; 18(11):1609-1678. PMID: 27567465.
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    64. Nattel S, Dobrev D. Electrophysiological and molecular mechanisms of paroxysmal atrial fibrillation. Nat Rev Cardiol. 2016 10; 13(10):575-90. PMID: 27489190.
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    65. Goette A, Kalman JM, Aguinaga L, Akar J, Cabrera JA, Chen SA, Chugh SS, Corradi D, D'Avila A, Dobrev D, Fenelon G, Gonzalez M, Hatem SN, Helm R, Hindricks G, Ho SY, Hoit B, Jalife J, Kim YH, Lip GY, Ma CS, Marcus GM, Murray K, Nogami A, Sanders P, Uribe W, Van Wagoner DR, Nattel S. EHRA/HRS/APHRS/SOLAECE expert consensus on Atrial cardiomyopathies: Definition, characterisation, and clinical implication. J Arrhythm. 2016 08; 32(4):247-78. PMID: 27588148.
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    66. Goette A, Kalman JM, Aguinaga L, Akar J, Cabrera JA, Chen SA, Chugh SS, Corradi D, D'Avila A, Dobrev D, Fenelon G, Gonzalez M, Hatem SN, Helm R, Hindricks G, Ho SY, Hoit B, Jalife J, Kim YH, Lip GY, Ma CS, Marcus GM, Murray K, Nogami A, Sanders P, Uribe W, Van Wagoner DR, Nattel S. EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication. Europace. 2016 Oct; 18(10):1455-1490. PMID: 27402624.
      View in: PubMed
    67. Goette A, Kalman JM, Aguinaga L, Akar J, Cabrera JA, Chen SA, Chugh SS, Corradi D, D'Avila A, Dobrev D, Fenelon G, Gonzalez M, Hatem SN, Helm R, Hindricks G, Ho SY, Hoit B, Jalife J, Kim YH, Lip GY, Ma CS, Marcus GM, Murray K, Nogami A, Sanders P, Uribe W, Van Wagoner DR, Nattel S. EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: Definition, characterization, and clinical implication. Heart Rhythm. 2017 01; 14(1):e3-e40. PMID: 27320515.
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    68. Molina CE, Heijman J, Dobrev D. Differences in Left Versus Right Ventricular Electrophysiological Properties in Cardiac Dysfunction and Arrhythmogenesis. Arrhythm Electrophysiol Rev. 2016 May; 5(1):14-9. PMID: 27403288.
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    69. Smith SA, Hughes LD, Kline CF, Kempton AN, Dorn LE, Curran J, Makara M, Webb TR, Wright P, Voigt N, Binkley PF, Janssen PM, Kilic A, Carnes CA, Dobrev D, Rasband MN, Hund TJ, Mohler PJ. Dysfunction of the ß2-spectrin-based pathway in human heart failure. Am J Physiol Heart Circ Physiol. 2016 06 01; 310(11):H1583-91. PMID: 27106045.
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    70. Heijman J, Dobrev D. Challenges to the translation of basic science findings to atrial fibrillation therapies. Future Cardiol. 2016 05; 12(3):251-4. PMID: 27091233.
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    71. Hartmann N, Mason FE, Braun I, Pabel S, Voigt N, Schotola H, Fischer TH, Dobrev D, Danner BC, Renner A, Gummert J, Belardinelli L, Frey N, Maier LS, Hasenfuss G, Sossalla S. The combined effects of ranolazine and dronedarone on human atrial and ventricular electrophysiology. J Mol Cell Cardiol. 2016 05; 94:95-106. PMID: 27056421.
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    72. Voigt N, Dobrev D. Atrial-Selective Potassium Channel Blockers. Card Electrophysiol Clin. 2016 06; 8(2):411-21. PMID: 27261831.
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    73. Schmidt C, Wiedmann F, Voigt N, Zhou XB, Heijman J, Lang S, Albert V, Kallenberger S, Ruhparwar A, Szabó G, Kallenbach K, Karck M, Borggrefe M, Biliczki P, Ehrlich JR, Baczkó I, Lugenbiel P, Schweizer PA, Donner BC, Katus HA, Dobrev D, Thomas D. Response to Letter Regarding Article, "Upregulation of K2P3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation". Circulation. 2016 Mar 15; 133(11):e440-1. PMID: 26976923.
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    74. Nattel S, Dobrev D. Deciphering the fundamental mechanisms of atrial fibrillation: a quest for over a century. Cardiovasc Res. 2016 Apr 01; 109(4):465-6. PMID: 26857417.
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    75. Stathopoulou K, Wittig I, Heidler J, Piasecki A, Richter F, Diering S, van der Velden J, Buck F, Donzelli S, Schröder E, Wijnker PJ, Voigt N, Dobrev D, Sadayappan S, Eschenhagen T, Carrier L, Eaton P, Cuello F. S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure. FASEB J. 2016 05; 30(5):1849-64. PMID: 26839380.
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    76. Heijman J, Schirmer I, Dobrev D. The multiple proarrhythmic roles of cardiac calcium-handling abnormalities: triggered activity, conduction abnormalities, beat-to-beat variability, and adverse remodelling. Europace. 2016 10; 18(10):1452-1454. PMID: 26826138.
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    77. Li N, Dobrev D, Wehrens XH. PITX2: a master regulator of cardiac channelopathy in atrial fibrillation? Cardiovasc Res. 2016 Mar 01; 109(3):345-7. PMID: 26782118.
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    78. Heijman J, Erfanian Abdoust P, Voigt N, Nattel S, Dobrev D. Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation. J Physiol. 2016 Feb 01; 594(3):537-53. PMID: 26582329.
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    79. Heijman J, Algalarrondo V, Voigt N, Melka J, Wehrens XH, Dobrev D, Nattel S. The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis. Cardiovasc Res. 2016 Apr 01; 109(4):467-79. PMID: 26705366.
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    80. Heijman J, Voigt N, Ghezelbash S, Schirmer I, Dobrev D. Calcium Handling Abnormalities as a Target for Atrial Fibrillation Therapeutics: How Close to Clinical Implementation? J Cardiovasc Pharmacol. 2015 Dec; 66(6):515-22. PMID: 25830486.
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    81. Voigt N, Heijman J, Dobrev D. New antiarrhythmic targets in atrial fibrillation. Future Cardiol. 2015; 11(6):645-54. PMID: 26609872.
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    82. Weber S, Meyer-Roxlau S, Wagner M, Dobrev D, El-Armouche A. Counteracting Protein Kinase Activity in the Heart: The Multiple Roles of Protein Phosphatases. Front Pharmacol. 2015; 6:270. PMID: 26617522.
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    83. Nattel S, Dobrev D. Innovative Therapeutics for Atrial Fibrillation: Imminent Breakthroughs or Much Ado About Nothing? J Cardiovasc Pharmacol. 2015 Nov; 66(5):409-11. PMID: 26371951.
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    160. Nishida K, Qi XY, Wakili R, Comtois P, Chartier D, Harada M, Iwasaki YK, Romeo P, Maguy A, Dobrev D, Michael G, Talajic M, Nattel S. Mechanisms of atrial tachyarrhythmias associated with coronary artery occlusion in a chronic canine model. Circulation. 2011 Jan 18; 123(2):137-46. PMID: 21200008.
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    161. Boontje NM, Merkus D, Zaremba R, Versteilen A, de Waard MC, Mearini G, de Beer VJ, Carrier L, Walker LA, Niessen HW, Dobrev D, Stienen GJ, Duncker DJ, van der Velden J. Enhanced myofilament responsiveness upon ß-adrenergic stimulation in post-infarct remodeled myocardium. J Mol Cell Cardiol. 2011 Mar; 50(3):487-99. PMID: 21156182.
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    162. Dobrev D, Voigt N, Wehrens XH. The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications. Cardiovasc Res. 2011 Mar 01; 89(4):734-43. PMID: 20943673.
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    163. Goette A, Hammwöhner M, Bukowska A, Scalera F, Martens-Lobenhoffer J, Dobrev D, Ravens U, Weinert S, Medunjanin S, Lendeckel U, Bode-Böger SM. The impact of rapid atrial pacing on ADMA and endothelial NOS. Int J Cardiol. 2012 Jan 26; 154(2):141-6. PMID: 20926145.
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    164. Wakili R, Yeh YH, Yan Qi X, Greiser M, Chartier D, Nishida K, Maguy A, Villeneuve LR, Boknik P, Voigt N, Krysiak J, Kääb S, Ravens U, Linke WA, Stienen GJ, Shi Y, Tardif JC, Schotten U, Dobrev D, Nattel S. Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs. Circ Arrhythm Electrophysiol. 2010 Oct; 3(5):530-41. PMID: 20660541.
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    165. Voigt N, Trausch A, Knaut M, Matschke K, Varró A, Van Wagoner DR, Nattel S, Ravens U, Dobrev D. Left-to-right atrial inward rectifier potassium current gradients in patients with paroxysmal versus chronic atrial fibrillation. Circ Arrhythm Electrophysiol. 2010 Oct; 3(5):472-80. PMID: 20657029.
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    166. Lendeckel U, Dobrev D, Goette A. Aldosterone-receptor antagonism as a potential therapeutic option for atrial fibrillation. Br J Pharmacol. 2010 Apr; 159(8):1581-3. PMID: 20388187.
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    167. Dobrev D, Nattel S. New antiarrhythmic drugs for treatment of atrial fibrillation. Lancet. 2010 Apr 03; 375(9721):1212-23. PMID: 20334907.
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    168. Wittköpper K, Fabritz L, Neef S, Ort KR, Grefe C, Unsöld B, Kirchhof P, Maier LS, Hasenfuss G, Dobrev D, Eschenhagen T, El-Armouche A. Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging. J Clin Invest. 2010 Feb; 120(2):617-26. PMID: 20071777.
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    169. Voigt N, Makary S, Nattel S, Dobrev D. Voltage-clamp-based methods for the detection of constitutively active acetylcholine-gated I(K,ACh) channels in the diseased heart. Methods Enzymol. 2010; 484:653-75. PMID: 21036255.
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    170. Dobrev D, Wehrens XH. Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak, and atrial fibrillation. Trends Cardiovasc Med. 2010 Jan; 20(1):30-4. PMID: 20685575.
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    171. Nishida K, Michael G, Dobrev D, Nattel S. Animal models for atrial fibrillation: clinical insights and scientific opportunities. Europace. 2010 Feb; 12(2):160-72. PMID: 19875395.
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    172. Dobrev D. Atrial Ca2+ signaling in atrial fibrillation as an antiarrhythmic drug target. Naunyn Schmiedebergs Arch Pharmacol. 2010 Mar; 381(3):195-206. PMID: 19784635.
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    173. Voigt N, Rozmaritsa N, Trausch A, Zimniak T, Christ T, Wettwer E, Matschke K, Dobrev D, Ravens U. Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillation. Naunyn Schmiedebergs Arch Pharmacol. 2010 Mar; 381(3):251-9. PMID: 19760273.
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    174. Chelu MG, Sarma S, Sood S, Wang S, van Oort RJ, Skapura DG, Li N, Santonastasi M, Müller FU, Schmitz W, Schotten U, Anderson ME, Valderrábano M, Dobrev D, Wehrens XH. Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest. 2009 Jul; 119(7):1940-51. PMID: 19603549.
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    175. Dobrev D. Ion channel portrait of the human sinus node: useful for a better understanding of sinus node function and dysfunction in humans? Circulation. 2009 Mar 31; 119(12):1556-8. PMID: 19332478.
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    176. Goette A, Bukowska A, Dobrev D, Pfeiffenberger J, Morawietz H, Strugala D, Wiswedel I, Röhl FW, Wolke C, Bergmann S, Bramlage P, Ravens U, Lendeckel U. Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor-mediated oxidative stress and microvascular flow abnormalities in the ventricles. Eur Heart J. 2009 Jun; 30(11):1411-20. PMID: 19269986.
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    177. Dobrev D, Goette A, Ravens U. Stroke prevention versus bleeding risk of vitamin-K antagonists: a double-edged sword in patients with atrial fibrillation who require surgery. Cardiovasc Ther. 2009; 27(4):223-5. PMID: 19903184.
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    178. Greiser M, Neuberger HR, Harks E, El-Armouche A, Boknik P, de Haan S, Verheyen F, Verheule S, Schmitz W, Ravens U, Nattel S, Allessie MA, Dobrev D, Schotten U. Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation. J Mol Cell Cardiol. 2009 Mar; 46(3):385-94. PMID: 19100271.
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    179. Dobrev D, Nattel S. Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeutics. J Cardiovasc Pharmacol. 2008 Oct; 52(4):293-9. PMID: 18791467.
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    180. Michael G, Xiao L, Qi XY, Dobrev D, Nattel S. Remodelling of cardiac repolarization: how homeostatic responses can lead to arrhythmogenesis. Cardiovasc Res. 2009 Feb 15; 81(3):491-9. PMID: 18826964.
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    181. Qi XY, Yeh YH, Xiao L, Burstein B, Maguy A, Chartier D, Villeneuve LR, Brundel BJ, Dobrev D, Nattel S. Cellular signaling underlying atrial tachycardia remodeling of L-type calcium current. Circ Res. 2008 Oct 10; 103(8):845-54. PMID: 18723446.
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    182. El-Armouche A, Wittköpper K, Degenhardt F, Weinberger F, Didié M, Melnychenko I, Grimm M, Peeck M, Zimmermann WH, Unsöld B, Hasenfuss G, Dobrev D, Eschenhagen T. Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy. Cardiovasc Res. 2008 Dec 01; 80(3):396-406. PMID: 18689792.
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    183. Yeh YH, Wakili R, Qi XY, Chartier D, Boknik P, Kääb S, Ravens U, Coutu P, Dobrev D, Nattel S. Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure. Circ Arrhythm Electrophysiol. 2008 Jun 01; 1(2):93-102. PMID: 19808399.
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    184. Dobrev D, Wettwer E. Four and a half LIM protein 1: a novel chaperone for atrium-specific Kv1.5 channels with a potential role in atrial arrhythmogenesis. Cardiovasc Res. 2008 Jun 01; 78(3):411-2. PMID: 18390898.
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    185. Nattel S, Burstein B, Dobrev D. Atrial remodeling and atrial fibrillation: mechanisms and implications. Circ Arrhythm Electrophysiol. 2008 Apr; 1(1):62-73. PMID: 19808395.
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    186. Sood S, Chelu MG, van Oort RJ, Skapura D, Santonastasi M, Dobrev D, Wehrens XH. Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation. Heart Rhythm. 2008 Jul; 5(7):1047-54. PMID: 18598963.
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    187. Dobrev D. New concepts in understanding and modulating atrial repolarisation in patients with atrial fibrillation. J Interv Card Electrophysiol. 2008 Aug; 22(2):107-10. PMID: 18330686.
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    188. Dobrev D. Cardiomyocyte Ca2+ overload in atrial tachycardia: is blockade of L-type Ca2+ channels a promising approach to prevent electrical remodeling and arrhythmogenesis? Naunyn Schmiedebergs Arch Pharmacol. 2007 Dec; 376(4):227-30. PMID: 17999053.
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    189. Voigt N, Maguy A, Yeh YH, Qi X, Ravens U, Dobrev D, Nattel S. Changes in I K, ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes. Cardiovasc Res. 2008 Jan; 77(1):35-43. PMID: 18006448.
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    190. Eichhorn B, Dobrev D. Vascular large conductance calcium-activated potassium channels: functional role and therapeutic potential. Naunyn Schmiedebergs Arch Pharmacol. 2007 Nov; 376(3):145-55. PMID: 17932654.
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    191. Greiser M, Halaszovich CR, Frechen D, Boknik P, Ravens U, Dobrev D, Lückhoff A, Schotten U. Pharmacological evidence for altered src kinase regulation of I (Ca,L) in patients with chronic atrial fibrillation. Naunyn Schmiedebergs Arch Pharmacol. 2007 Aug; 375(6):383-92. PMID: 17593353.
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    192. El-Armouche A, Pohlmann L, Schlossarek S, Starbatty J, Yeh YH, Nattel S, Dobrev D, Eschenhagen T, Carrier L. Decreased phosphorylation levels of cardiac myosin-binding protein-C in human and experimental heart failure. J Mol Cell Cardiol. 2007 Aug; 43(2):223-9. PMID: 17560599.
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    193. Wettwer E, Christ T, Dobrev D, Ravens U. Novel anti-arrhythmic agents for the treatment of atrial fibrillation. Curr Opin Pharmacol. 2007 Apr; 7(2):214-8. PMID: 17303472.
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    194. Voigt N, Friedrich A, Bock M, Wettwer E, Christ T, Knaut M, Strasser RH, Ravens U, Dobrev D. Differential phosphorylation-dependent regulation of constitutively active and muscarinic receptor-activated IK,ACh channels in patients with chronic atrial fibrillation. Cardiovasc Res. 2007 Jun 01; 74(3):426-37. PMID: 17362895.
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    195. Dobrev D. 5-hydroxytryptamine and atrial arrhythmogenesis: a "culprit mechanism" or bystander in patients with chronic atrial fibrillation? J Mol Cell Cardiol. 2007 Jan; 42(1):51-3. PMID: 17064728.
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    196. El-Armouche A, Boknik P, Eschenhagen T, Carrier L, Knaut M, Ravens U, Dobrev D. Molecular determinants of altered Ca2+ handling in human chronic atrial fibrillation. Circulation. 2006 Aug 15; 114(7):670-80. PMID: 16894034.
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    197. Dobrev D, Ravens U. Do genetics help to better understand the underlying mechanisms of atrial fibrillation? Eur Heart J. 2006 Jul; 27(14):1640-1. PMID: 16760202.
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    198. El-Armouche A, Bednorz A, Pamminger T, Ditz D, Didié M, Dobrev D, Eschenhagen T. Role of calcineurin and protein phosphatase-2A in the regulation of phosphatase inhibitor-1 in cardiac myocytes. Biochem Biophys Res Commun. 2006 Aug 04; 346(3):700-6. PMID: 16774736.
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    199. Dobrev D. Electrical remodeling in atrial fibrillation. Herz. 2006 Apr; 31(2):108-12; quiz 142-3. PMID: 16738832.
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    200. Gaborit N, Steenman M, Lamirault G, Le Meur N, Le Bouter S, Lande G, Léger J, Charpentier F, Christ T, Dobrev D, Escande D, Nattel S, Demolombe S. Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation. Circulation. 2005 Jul 26; 112(4):471-81. PMID: 16027256.
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    201. Christ T, Adolph E, Schindelhauer S, Wettwer E, Dobrev D, Wallukat G, Ravens U. Effects of immunoglobulin G from patients with dilated cardiomyopathy on rat cardiomyocytes. Basic Clin Pharmacol Toxicol. 2005 Jun; 96(6):445-52. PMID: 15910408.
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    202. Vest JA, Wehrens XH, Reiken SR, Lehnart SE, Dobrev D, Chandra P, Danilo P, Ravens U, Rosen MR, Marks AR. Defective cardiac ryanodine receptor regulation during atrial fibrillation. Circulation. 2005 Apr 26; 111(16):2025-32. PMID: 15851612.
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    203. Frey UH, Nückel H, Dobrev D, Manthey I, Sandalcioglu IE, Eisenhardt A, Worm K, Hauner H, Siffert W. Quantification of G protein Gaalphas subunit splice variants in different human tissues and cells using pyrosequencing. Gene Expr. 2005; 12(2):69-81. PMID: 15892449.
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    204. Christ T, Rauwolf T, Braun M, Dobrev D, Ravens U, Strasser RH. Recording atrial monophasic action potentials using standard pacemaker leads: an alternative way to study electrophysiology properties of the human atrium in vivo? Pacing Clin Electrophysiol. 2004 Dec; 27(12):1632-7. PMID: 15613126.
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    205. Christ T, Wüst M, Matthes J, Jänchen M, Jürgens S, Herzig S, Wettwer E, Dobrev D, Matschke K, Mebs D, Ravens U. An aqueous extract of the marine sponge Ectyoplasia ferox stimulates L-type Ca2+-current by direct interaction with the Cav1.2 subunit. Naunyn Schmiedebergs Arch Pharmacol. 2004 Dec; 370(6):474-83. PMID: 15599709.
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    206. Wettwer E, Hála O, Christ T, Heubach JF, Dobrev D, Knaut M, Varró A, Ravens U. Role of IKur in controlling action potential shape and contractility in the human atrium: influence of chronic atrial fibrillation. Circulation. 2004 Oct 19; 110(16):2299-306. PMID: 15477405.
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    207. Dobrev D, Christ T, Ravens U. Muscarinic subtype-2 receptor autoantibodies: actors or bystanders in human atrial fibrillation? Eur Heart J. 2004 Jul; 25(13):1091-2. PMID: 15231365.
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    208. Schindler C, Dobrev D, Grossmann M, Francke K, Pittrow D, Kirch W. Mechanisms of beta-adrenergic receptor-mediated venodilation in humans. Clin Pharmacol Ther. 2004 Jan; 75(1):49-59. PMID: 14749691.
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    209. Balana B, Dobrev D, Wettwer E, Christ T, Knaut M, Ravens U. Decreased ATP-sensitive K(+) current density during chronic human atrial fibrillation. J Mol Cell Cardiol. 2003 Dec; 35(12):1399-405. PMID: 14654366.
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    210. Dobrev D. Transcription factors for ion channels: active or passive players in cardiac remodeling? Cardiovasc Res. 2003 Nov 01; 60(2):226-7. PMID: 14613850.
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    211. Dobrev D, Ravens U. Remodeling of cardiomyocyte ion channels in human atrial fibrillation. Basic Res Cardiol. 2003 May; 98(3):137-48. PMID: 12883831.
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    212. Dobrev D, Ravens U. Therapeutically relevant concentrations of neomycin selectively inhibit P-type Ca2+ channels in rat striatum. Eur J Pharmacol. 2003 Feb 14; 461(2-3):105-11. PMID: 12586205.
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    213. Ravens U, Dobrev D. Cardiac sympathetic innervation and control of potassium channel function. J Mol Cell Cardiol. 2003 Feb; 35(2):137-9. PMID: 12606253.
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    214. Christ T, Schier M, Brattström A, Muth G, Hartmann A, Dobrev D, Ravens U. Rate-adaptive pacing using intracardiac impedance shows no evidence for positive feedback during dobutamine stress test. Europace. 2002 Jul; 4(3):311-5. PMID: 12134978.
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    215. Ravens U, Nitsche I, Haag C, Dobrev D. What is a good tutorial from the student's point of view? Evaluation of tutorials in a newly established PBL block course "Basics of Drug Therapy". Naunyn Schmiedebergs Arch Pharmacol. 2002 Jul; 366(1):69-76. PMID: 12107636.
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    216. Dobrev D, Wettwer E, Kortner A, Knaut M, Schüler S, Ravens U. Human inward rectifier potassium channels in chronic and postoperative atrial fibrillation. Cardiovasc Res. 2002 May; 54(2):397-404. PMID: 12062344.
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