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DENNIS T. VILLAREAL

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
DivisionMedicine-Endocrinology
Address2002 Holcombe Blvd., Building 110
Houston TX 77030
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentHuffington Center on Aging
    DivisionHuffington Ctr on Aging


    Collapse Research 
    Collapse research activities and funding
    K23RR016191     (VILLAREAL, DENNIS T.)Apr 1, 2001 - Mar 31, 2005
    NIH/NCRR
    DHEA+EXERCISE-EFFECT ON SARCOPENIA &OSTEOPENIA OF AGING
    Role: Principal Investigator

    R01AG025501     (VILLAREAL, DENNIS T.)Jan 1, 2005 - Dec 31, 2012
    NIH/NIA
    Weight Loss and Exercise in Frail Obese Elderly Subjects
    Role: Principal Investigator

    R01AG031176     (VILLAREAL, DENNIS T.)May 1, 2009 - Apr 30, 2017
    NIH/NIA
    EXERCISE INTERVENTIONS DURING VOLUNTARY WEIGHT LOSS IN OBESE OLDER ADULTS
    Role: Principal Investigator

    I01CX000906     (VILLAREAL, DENNIS T.)Apr 1, 2014 - Dec 31, 2019
    VA
    Testosterone Replacement to Augment Lifestyle Therapy in Obese Older Veterans
    Role: Principal Investigator

    IS1BX003142     (VILLAREAL, DENNIS T.)Jan 1, 2015 - Sep 30, 2015
    VA
    Request for High-Resolution Peripheral Quantitative Computed Tomography
    Role: Principal Investigator

    R01DK109950     (VILLAREAL, DENNIS T.)Jun 1, 2017 - May 31, 2022
    NIH/NIDDK
    DOES LIFESTYLE INTERVENTION IN OBESE OLDER ADULTS IMPROVE BONE QUALITY?
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jiang BC, Villareal DT. Weight Loss-Induced Reduction of Bone Mineral Density in Older Adults with Obesity. J Nutr Gerontol Geriatr. 2019 Feb 22; 1-15. PMID: 30794099.
      View in: PubMed
    2. Jiang BC, Villareal DT. Therapeutic and lifestyle approaches to obesity in older persons. Curr Opin Clin Nutr Metab Care. 2019 Jan; 22(1):30-36. PMID: 30346314.
      View in: PubMed
    3. Jankowski CM, Wolfe P, Schmiege SJ, Nair KS, Khosla S, Jensen M, von Muhlen D, Laughlin GA, Kritz-Silverstein D, Bergstrom J, Bettencourt R, Weiss EP, Villareal DT, Kohrt WM. Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials. Clin Endocrinol (Oxf). 2019 Feb; 90(2):293-300. PMID: 30421439.
      View in: PubMed
    4. Colleluori G, Aguirre LE, Qualls C, Chen R, Napoli N, Villareal DT, Armamento-Villareal R. Adipocytes ESR1 Expression, Body Fat and Response to Testosterone Therapy in Hypogonadal Men Vary According to Estradiol Levels. Nutrients. 2018 Sep 04; 10(9). PMID: 30181488.
      View in: PubMed
    5. Batsis JA, Villareal DT. Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies. Nat Rev Endocrinol. 2018 Sep; 14(9):513-537. PMID: 30065268.
      View in: PubMed
    6. Colleluori G, Chen R, Napoli N, Aguirre LE, Qualls C, Villareal DT, Armamento-Villareal R. Fat Mass Follows a U-Shaped Distribution Based on Estradiol Levels in Postmenopausal Women. Front Endocrinol (Lausanne). 2018; 9:315. PMID: 30013511.
      View in: PubMed
    7. Pahor M, Kritchevsky SB, Waters DL, Villareal DT, Morley J, Hare JM, Vellas B. Designing Drug Trials for Frailty: ICFSR Task Force 2018. J Frailty Aging. 2018; 7(3):150-154. PMID: 30095144.
      View in: PubMed
    8. Dent E, Morley JE, Cruz-Jentoft AJ, Arai H, Kritchevsky SB, Guralnik J, Bauer JM, Pahor M, Clark BC, Cesari M, Ruiz J, Sieber CC, Aubertin-Leheudre M, Waters DL, Visvanathan R, Landi F, Villareal DT, Fielding R, Won CW, Theou O, Martin FC, Dong B, Woo J, Flicker L, Ferrucci L, Merchant RA, Cao L, Cederholm T, Ribeiro SML, Rodríguez-Mañas L, Anker SD, Lundy J, Gutiérrez Robledo LM, Bautmans I, Aprahamian I, Schols JMGA, Izquierdo M, Vellas B. International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management. J Nutr Health Aging. 2018; 22(10):1148-1161. PMID: 30498820.
      View in: PubMed
    9. Racette SB, Rochon J, Uhrich ML, Villareal DT, DAS SK, Fontana L, Bhapkar M, Martin CK, Redman LM, Fuss PJ, Roberts SB, Kraus WE. Effects of Two Years of Calorie Restriction on Aerobic Capacity and Muscle Strength. Med Sci Sports Exerc. 2017 Nov; 49(11):2240-2249. PMID: 29045325.
      View in: PubMed
    10. Aguirre LE, Colleluori G, Dorin R, Robbins D, Chen R, Jiang B, Qualls C, Villareal DT, Armamento-Villareal R. Hypogonadal Men with Higher Body Mass Index have Higher Bone Density and Better Bone Quality but Reduced Muscle Density. Calcif Tissue Int. 2017 12; 101(6):602-611. PMID: 28856390.
      View in: PubMed
    11. Colleluori G, Napoli N, Phadnis U, Armamento-Villareal R, Villareal DT. Effect of Weight Loss, Exercise, or Both on Undercarboxylated Osteocalcin and Insulin Secretion in Frail, Obese Older Adults. Oxid Med Cell Longev. 2017; 2017:4807046. PMID: 28951766.
      View in: PubMed
    12. Villareal DT, Waters DL, Qualls C. Exercise Type in Dieting Obese Older Adults. N Engl J Med. 2017 08 10; 377(6):599-600. PMID: 28792874.
      View in: PubMed
    13. Villareal DT, Aguirre L, Gurney AB, Waters DL, Sinacore DR, Colombo E, Armamento-Villareal R, Qualls C. Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults. N Engl J Med. 2017 05 18; 376(20):1943-1955. PMID: 28514618.
      View in: PubMed
    14. Colleluori G, Aguirre L, Dorin R, Robbins D, Blevins D, Barnouin Y, Chen R, Qualls C, Villareal DT, Armamento-Villareal R. Hypogonadal men with type 2 diabetes mellitus have smaller bone size and lower bone turnover. Bone. 2017 06; 99:14-19. PMID: 28323146.
      View in: PubMed
    15. Das SK, Roberts SB, Bhapkar MV, Villareal DT, Fontana L, Martin CK, Racette SB, Fuss PJ, Kraus WE, Wong WW, Saltzman E, Pieper CF, Fielding RA, Schwartz AV, Ravussin E, Redman LM. Body-composition changes in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE)-2 study: a 2-y randomized controlled trial of calorie restriction in nonobese humans. Am J Clin Nutr. 2017 04; 105(4):913-927. PMID: 28228420.
      View in: PubMed
    16. Qualls C, Waters DL, Vellas B, Villareal DT, Garry PJ, Gallini A, Andrieu S. Reversible States of Physical and/or Cognitive Dysfunction: A 9-Year Longitudinal Study. J Nutr Health Aging. 2017; 21(3):271-275. PMID: 28244566.
      View in: PubMed
    17. Weiss EP, Jordan RC, Frese EM, Albert SG, Villareal DT. Effects of Weight Loss on Lean Mass, Strength, Bone, and Aerobic Capacity. Med Sci Sports Exerc. 2017 01; 49(1):206-217. PMID: 27580151.
      View in: PubMed
    18. Pokharel Y, Sun W, Villareal DT, Selvin E, Virani SS, Ndumele CE, Hoogeveen RC, Coresh J, Boerwinkle E, Butler KR, Solomon SD, Pankow JS, Bozkurt B, Ballantyne CM, Nambi V. Association between high-sensitivity troponin T and cardiovascular risk in individuals with and without metabolic syndrome: The ARIC study. Eur J Prev Cardiol. 2017 04; 24(6):628-638. PMID: 27941157.
      View in: PubMed
    19. Weiss EP, Reeds DN, Ezekiel UR, Albert SG, Villareal DT. Circulating cytokines as determinants of weight loss-induced improvements in insulin sensitivity. Endocrine. 2017 Jan; 55(1):153-164. PMID: 27605038.
      View in: PubMed
    20. Weiss EP, Albert SG, Reeds DN, Kress KS, McDaniel JL, Klein S, Villareal DT. Effects of matched weight loss from calorie restriction, exercise, or both on cardiovascular disease risk factors: a randomized intervention trial. Am J Clin Nutr. 2016 Sep; 104(3):576-86. PMID: 27465384; PMCID: PMC4997297 [Available on 09/01/17].
    21. Meydani SN, Das SK, Pieper CF, Lewis MR, Klein S, Dixit VD, Gupta AK, Villareal DT, Bhapkar M, Huang M, Fuss PJ, Roberts SB, Holloszy JO, Fontana L. Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans. Aging (Albany NY). 2016 07; 8(7):1416-31. PMID: 27410480.
      View in: PubMed
    22. Romashkan SV, Das SK, Villareal DT, Ravussin E, Redman LM, Rochon J, Bhapkar M, Kraus WE. Safety of two-year caloric restriction in non-obese healthy individuals. Oncotarget. 2016 Apr 12; 7(15):19124-33. PMID: 26992237; PMCID: PMC4991370.
    23. Armamento-Villareal R, Wingkun N, Aguirre LE, Kulkarny V, Napoli N, Colleluori G, Qualls C, Villareal DT. The FTO gene is associated with a paradoxically favorable cardiometabolic risk profile in frail, obese older adults. Pharmacogenet Genomics. 2016 Apr; 26(4):154-160. PMID: 26709911.
      View in: PubMed
    24. Armamento-Villareal R, Aguirre LE, Qualls C, Villareal DT. Effect of Lifestyle Intervention on the Hormonal Profile of Frail, Obese Older Men. J Nutr Health Aging. 2016 Mar; 20(3):334-40. PMID: 26892583.
      View in: PubMed
    25. Yang L, Licastro D, Cava E, Veronese N, Spelta F, Rizza W, Bertozzi B, Villareal DT, Hotamisligil GS, Holloszy JO, Fontana L. Long-Term Calorie Restriction Enhances Cellular Quality-Control Processes in Human Skeletal Muscle. Cell Rep. 2016 Jan 26; 14(3):422-428. PMID: 26774472.
      View in: PubMed
    26. Vellas B, Fielding R, Bhasin S, Cerreta F, Goodpaster B, Guralnik JM, Kritchevsky S, Legrand V, Forkin C, Magaziner J, Morley JE, Rodriguez-Manas L, Roubenoff R, Studenski S, Villareal DT, Cesari M. Sarcopenia Trials in Specific Diseases: Report by the International Conference on Frailty and Sarcopenia Research Task Force. J Frailty Aging. 2016; 5(4):194-200. PMID: 27883164.
      View in: PubMed
    27. Aguirre LE, Villareal DT. Physical Exercise as Therapy for Frailty. Nestle Nutr Inst Workshop Ser. 2015; 83:83-92. PMID: 26524568; PMCID: PMC4712448.
    28. Fontana L, Villareal DT, Das SK, Smith SR, Meydani SN, Pittas AG, Klein S, Bhapkar M, Rochon J, Ravussin E, Holloszy JO. Effects of 2-year calorie restriction on circulating levels of IGF-1, IGF-binding proteins and cortisol in nonobese men and women: a randomized clinical trial. Aging Cell. 2016 Feb; 15(1):22-7. PMID: 26443692; PMCID: PMC4717266.
    29. Villareal DT, Fontana L, Das SK, Redman L, Smith SR, Saltzman E, Bales C, Rochon J, Pieper C, Huang M, Lewis M, Schwartz AV. Effect of Two-Year Caloric Restriction on Bone Metabolism and Bone Mineral Density in Non-Obese Younger Adults: A Randomized Clinical Trial. J Bone Miner Res. 2016 Jan; 31(1):40-51. PMID: 26332798; PMCID: PMC4834845 [Available on 01/01/17].
    30. Aguirre LE, Colleluori G, Fowler KE, Jan IZ, Villareal K, Qualls C, Robbins D, Villareal DT, Armamento-Villareal R. High aromatase activity in hypogonadal men is associated with higher spine bone mineral density, increased truncal fat and reduced lean mass. Eur J Endocrinol. 2015 Aug; 173(2):167-74. PMID: 26142101.
      View in: PubMed
    31. Ravussin E, Redman LM, Rochon J, Das SK, Fontana L, Kraus WE, Romashkan S, Williamson DA, Meydani SN, Villareal DT, Smith SR, Stein RI, Scott TM, Stewart TM, Saltzman E, Klein S, Bhapkar M, Martin CK, Gilhooly CH, Holloszy JO, Hadley EC, Roberts SB. A 2-Year Randomized Controlled Trial of Human Caloric Restriction: Feasibility and Effects on Predictors of Health Span and Longevity. J Gerontol A Biol Sci Med Sci. 2015 Sep; 70(9):1097-104. PMID: 26187233; PMCID: PMC4841173.
    32. Weiss EP, Albert SG, Reeds DN, Kress KS, Ezekiel UR, McDaniel JL, Patterson BW, Klein S, Villareal DT. Calorie Restriction and Matched Weight Loss From Exercise: Independent and Additive Effects on Glucoregulation and the Incretin System in Overweight Women and Men. Diabetes Care. 2015 Jul; 38(7):1253-62. PMID: 25877812.
      View in: PubMed
    33. Armamento-Villareal R, Napoli N, Waters D, Villareal D. Fat, muscle, and bone interactions in obesity and the metabolic syndrome. Int J Endocrinol. 2014; 2014:247076. PMID: 25309593; PMCID: PMC4181788.
    34. Aguirre LE, Jan IZ, Fowler K, Waters DL, Villareal DT, Armamento-Villareal R. Testosterone and Adipokines are Determinants of Physical Performance, Strength, and Aerobic Fitness in Frail, Obese, Older Adults. Int J Endocrinol. 2014; 2014:507395. PMID: 25165472; PMCID: PMC4140116.
    35. Aguirre L, Napoli N, Waters D, Qualls C, Villareal DT, Armamento-Villareal R. Increasing adiposity is associated with higher adipokine levels and lower bone mineral density in obese older adults. J Clin Endocrinol Metab. 2014 Sep; 99(9):3290-7. PMID: 24878039; PMCID: PMC4154102.
    36. Napoli N, Shah K, Waters DL, Sinacore DR, Qualls C, Villareal DT. Effect of weight loss, exercise, or both on cognition and quality of life in obese older adults. Am J Clin Nutr. 2014 Jul; 100(1):189-98. PMID: 24787497; PMCID: PMC4144098.
    37. Waters DL, Wayne SJ, Andrieu S, Cesari M, Villareal DT, Garry P, Vellas B. Sexually dimorphic patterns of nutritional intake and eating behaviors in community-dwelling older adults with normal and slow gait speed. J Nutr Health Aging. 2014 Mar; 18(3):228-33. PMID: 24626748.
      View in: PubMed
    38. Shah K, Gleason L, Villareal DT. Vitamin K and bone health in older adults. J Nutr Gerontol Geriatr. 2014; 33(1):10-22. PMID: 24597993.
      View in: PubMed
    39. Bouchonville MF, Villareal DT. Sarcopenic obesity: how do we treat it? Curr Opin Endocrinol Diabetes Obes. 2013 Oct; 20(5):412-9. PMID: 23974769; PMCID: PMC4046899.
    40. Armamento-Villareal R, Aguirre L, Napoli N, Shah K, Hilton T, Sinacore DR, Qualls C, Villareal DT. Changes in thigh muscle volume predict bone mineral density response to lifestyle therapy in frail, obese older adults. Osteoporos Int. 2014 Feb; 25(2):551-8. PMID: 23892583; PMCID: PMC3903658.
    41. Bouchonville M, Armamento-Villareal R, Shah K, Napoli N, Sinacore DR, Qualls C, Villareal DT. Weight loss, exercise or both and cardiometabolic risk factors in obese older adults: results of a randomized controlled trial. Int J Obes (Lond). 2014 Mar; 38(3):423-31. PMID: 23823329; PMCID: PMC3835728.
    42. Mercken EM, Crosby SD, Lamming DW, JeBailey L, Krzysik-Walker S, Villareal DT, Capri M, Franceschi C, Zhang Y, Becker K, Sabatini DM, de Cabo R, Fontana L. Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile. Aging Cell. 2013 Aug; 12(4):645-51. PMID: 23601134; PMCID: PMC3714316.
    43. Waters DL, Ward AL, Villareal DT. Weight loss in obese adults 65years and older: a review of the controversy. Exp Gerontol. 2013 Oct; 48(10):1054-61. PMID: 23403042; PMCID: PMC3714333.
    44. Waters DL, Vawter R, Qualls C, Chode S, Armamento-Villareal R, Villareal DT. Long-term maintenance of weight loss after lifestyle intervention in frail, obese older adults. J Nutr Health Aging. 2013 Jan; 17(1):3-7. PMID: 23299370; PMCID: PMC3580336.
    45. Weiss EP, Villareal DT, Ehsani AA, Fontana L, Holloszy JO. Dehydroepiandrosterone replacement therapy in older adults improves indices of arterial stiffness. Aging Cell. 2012 Oct; 11(5):876-84. PMID: 22712469; PMCID: PMC3444670.
    46. Shah K, Villareal DT. Weight loss and improved fitness slow down the decline in mobility in obese adults with type 2 diabetes. Evid Based Med. 2013 Apr; 18(2):e18. PMID: 22782922; PMCID: PMC3605213.
    47. Smith GI, Villareal DT, Sinacore DR, Shah K, Mittendorfer B. Muscle protein synthesis response to exercise training in obese, older men and women. Med Sci Sports Exerc. 2012 Jul; 44(7):1259-66. PMID: 22246218; PMCID: PMC3354005.
    48. Armamento-Villareal R, Sadler C, Napoli N, Shah K, Chode S, Sinacore DR, Qualls C, Villareal DT. Weight loss in obese older adults increases serum sclerostin and impairs hip geometry but both are prevented by exercise training. J Bone Miner Res. 2012 May; 27(5):1215-21. PMID: 22392834; PMCID: PMC3361603.
    49. Wice BM, Reeds DN, Tran HD, Crimmins DL, Patterson BW, Dunai J, Wallendorf MJ, Ladenson JH, Villareal DT, Polonsky KS. Xenin-25 amplifies GIP-mediated insulin secretion in humans with normal and impaired glucose tolerance but not type 2 diabetes. Diabetes. 2012 Jul; 61(7):1793-800. PMID: 22522617.
      View in: PubMed
    50. Niekamp K, Zavorsky GS, Fontana L, McDaniel JL, Villareal DT, Weiss EP. Systemic acid load from the diet affects maximal-exercise RER. Med Sci Sports Exerc. 2012 Apr; 44(4):709-15. PMID: 21912302; PMCID: PMC3729016.
    51. Bugg JM, Shah K, Villareal DT, Head D. Cognitive and neural correlates of aerobic fitness in obese older adults. Exp Aging Res. 2012; 38(2):131-45. PMID: 22404537; PMCID: PMC3324124.
    52. Shah K, Villareal DT. PREVENTING FRAILTY IN OBESE OLDER ADULTS. J Frailty Aging. 2012; 1(2):47-9. PMID: 25364705; PMCID: PMC4212326.
    53. Shah K, Armamento-Villareal R, Parimi N, Chode S, Sinacore DR, Hilton TN, Napoli N, Qualls C, Villareal DT. Exercise training in obese older adults prevents increase in bone turnover and attenuates decrease in hip bone mineral density induced by weight loss despite decline in bone-active hormones. J Bone Miner Res. 2011 Dec; 26(12):2851-9. PMID: 21786319; PMCID: PMC3206995.
    54. Murphy JC, McDaniel JL, Mora K, Villareal DT, Fontana L, Weiss EP. Preferential reductions in intermuscular and visceral adipose tissue with exercise-induced weight loss compared with calorie restriction. J Appl Physiol (1985). 2012 Jan; 112(1):79-85. PMID: 22016371; PMCID: PMC3290417.
    55. Villareal DT, Smith GI, Shah K, Mittendorfer B. Effect of weight loss on the rate of muscle protein synthesis during fasted and fed conditions in obese older adults. Obesity (Silver Spring). 2012 Sep; 20(9):1780-6. PMID: 21938075; PMCID: PMC3291735.
    56. Weiss EP, Villareal DT, Fontana L, Han DH, Holloszy JO. Dehydroepiandrosterone (DHEA) replacement decreases insulin resistance and lowers inflammatory cytokines in aging humans. Aging (Albany NY). 2011 May; 3(5):533-42. PMID: 21566261; PMCID: PMC3156603.
    57. Shah K, Villareal DT. Combination treatment to CONQUER obesity? Lancet. 2011 Apr 16; 377(9774):1295-7. PMID: 21497686.
      View in: PubMed
    58. Villareal DT, Chode S, Parimi N, Sinacore DR, Hilton T, Armamento-Villareal R, Napoli N, Qualls C, Shah K. Weight loss, exercise, or both and physical function in obese older adults. N Engl J Med. 2011 Mar 31; 364(13):1218-29. PMID: 21449785; PMCID: PMC3114602.
    59. Villareal DT, Kotyk JJ, Armamento-Villareal RC, Kenguva V, Seaman P, Shahar A, Wald MJ, Kleerekoper M, Fontana L. Reduced bone mineral density is not associated with significantly reduced bone quality in men and women practicing long-term calorie restriction with adequate nutrition. Aging Cell. 2011 Feb; 10(1):96-102. PMID: 20969721; PMCID: PMC3607368.
    60. Villareal DT, Smith GI, Sinacore DR, Shah K, Mittendorfer B. Regular multicomponent exercise increases physical fitness and muscle protein anabolism in frail, obese, older adults. Obesity (Silver Spring). 2011 Feb; 19(2):312-8. PMID: 20489691; PMCID: PMC3069710.
    61. Smith GI, Villareal DT, Lambert CP, Reeds DN, Mohammed BS, Mittendorfer B. Timing of the initial muscle biopsy does not affect the measured muscle protein fractional synthesis rate during basal, postabsorptive conditions. J Appl Physiol (1985). 2010 Feb; 108(2):363-8. PMID: 19940095; PMCID: PMC2822667.
    62. Villareal DT, Robertson H, Bell GI, Patterson BW, Tran H, Wice B, Polonsky KS. TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action. Diabetes. 2010 Feb; 59(2):479-85. PMID: 19934000.
      View in: PubMed
    63. Napoli N, Varadharajan A, Rini GB, Del Fiacco R, Yarramaneni J, Mumm S, Villareal DT, Armamento-Villareal R. Effects of polymorphisms of the sex hormone-binding globulin (SHBG) gene on free estradiol and bone mineral density. Bone. 2009 Dec; 45(6):1169-74. PMID: 19679209; PMCID: PMC3689651.
    64. Villareal DT, Koster JC, Robertson H, Akrouh A, Miyake K, Bell GI, Patterson BW, Nichols CG, Polonsky KS. Kir6.2 variant E23K increases ATP-sensitive K+ channel activity and is associated with impaired insulin release and enhanced insulin sensitivity in adults with normal glucose tolerance. Diabetes. 2009 Aug; 58(8):1869-78. PMID: 19491206.
      View in: PubMed
    65. Shah K, Stufflebam A, Hilton TN, Sinacore DR, Klein S, Villareal DT. Diet and exercise interventions reduce intrahepatic fat content and improve insulin sensitivity in obese older adults. Obesity (Silver Spring). 2009 Dec; 17(12):2162-8. PMID: 19390517; PMCID: PMC2793412.
    66. Weiss EP, Shah K, Fontana L, Lambert CP, Holloszy JO, Villareal DT. Dehydroepiandrosterone replacement therapy in older adults: 1- and 2-y effects on bone. Am J Clin Nutr. 2009 May; 89(5):1459-67. PMID: 19321570; PMCID: PMC2677000.
    67. Fontana L, Weiss EP, Villareal DT, Klein S, Holloszy JO. Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. Aging Cell. 2008 10; 7(5):681-7. PMID: 18843793.
      View in: PubMed
    68. Sinacore DR, Hastings MK, Bohnert KL, Fielder FA, Villareal DT, Blair VP, Johnson JE. Inflammatory osteolysis in diabetic neuropathic (charcot) arthropathies of the foot. Phys Ther. 2008 Nov; 88(11):1399-407. PMID: 18801857; PMCID: PMC2579909.
    69. Hofer T, Fontana L, Anton SD, Weiss EP, Villareal D, Malayappan B, Leeuwenburgh C. Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans. Rejuvenation Res. 2008 Aug; 11(4):793-9. PMID: 18729811; PMCID: PMC2724865.
    70. Frimel TN, Sinacore DR, Villareal DT. Exercise attenuates the weight-loss-induced reduction in muscle mass in frail obese older adults. Med Sci Sports Exerc. 2008 Jul; 40(7):1213-9. PMID: 18580399; PMCID: PMC2650077.
    71. Weiss EP, Arif H, Villareal DT, Marzetti E, Holloszy JO. Endothelial function after high-sugar-food ingestion improves with endurance exercise performed on the previous day. Am J Clin Nutr. 2008 Jul; 88(1):51-7. PMID: 18614723.
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    72. Racette SB, Weiss EP, Schechtman KB, Steger-May K, Villareal DT, Obert KA, Holloszy JO. Influence of weekend lifestyle patterns on body weight. Obesity (Silver Spring). 2008 Aug; 16(8):1826-30. PMID: 18551108; PMCID: PMC3740215.
    73. Lambert CP, Wright NR, Finck BN, Villareal DT. Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons. J Appl Physiol (1985). 2008 Aug; 105(2):473-8. PMID: 18535122; PMCID: PMC2519937.
    74. Shah K, Wingkun NJ, Lambert CP, Villareal DT. Weight-loss therapy improves endurance capacity in obese older adults. J Am Geriatr Soc. 2008 Jun; 56(6):1157-9. PMID: 18554372; PMCID: PMC3680883.
    75. Weiss EP, Villareal DT, Racette SB, Steger-May K, Premachandra BN, Klein S, Fontana L. Caloric restriction but not exercise-induced reductions in fat mass decrease plasma triiodothyronine concentrations: a randomized controlled trial. Rejuvenation Res. 2008 Jun; 11(3):605-9. PMID: 18593278; PMCID: PMC2649744.
    76. Villareal DT, Banks MR, Patterson BW, Polonsky KS, Klein S. Weight loss therapy improves pancreatic endocrine function in obese older adults. Obesity (Silver Spring). 2008 Jun; 16(6):1349-54. PMID: 18388888; PMCID: PMC2799929.
    77. Smith GI, Atherton P, Villareal DT, Frimel TN, Rankin D, Rennie MJ, Mittendorfer B. Differences in muscle protein synthesis and anabolic signaling in the postabsorptive state and in response to food in 65-80 year old men and women. PLoS One. 2008 Mar 26; 3(3):e1875. PMID: 18365020; PMCID: PMC2267222.
    78. Villareal DT, Shah K, Banks MR, Sinacore DR, Klein S. Effect of weight loss and exercise therapy on bone metabolism and mass in obese older adults: a one-year randomized controlled trial. J Clin Endocrinol Metab. 2008 Jun; 93(6):2181-7. PMID: 18364384; PMCID: PMC2435639.
    79. Riordan MM, Weiss EP, Meyer TE, Ehsani AA, Racette SB, Villareal DT, Fontana L, Holloszy JO, Kovács SJ. The effects of caloric restriction- and exercise-induced weight loss on left ventricular diastolic function. Am J Physiol Heart Circ Physiol. 2008 Mar; 294(3):H1174-82. PMID: 18162561.
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    80. Arif H, Racette SB, Villareal DT, Holloszy JO, Weiss EP. Comparison of methods for assessing abdominal adipose tissue from magnetic resonance images. Obesity (Silver Spring). 2007 Sep; 15(9):2240-4. PMID: 17890492.
      View in: PubMed
    81. Smith GI, Villareal DT, Mittendorfer B. Measurement of human mixed muscle protein fractional synthesis rate depends on the choice of amino acid tracer. Am J Physiol Endocrinol Metab. 2007 Sep; 293(3):E666-71. PMID: 17535855.
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    82. Evans EM, Racette SB, Van Pelt RE, Peterson LR, Villareal DT. Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women. Menopause. 2007 May-Jun; 14(3 Pt 1):481-8. PMID: 17213752; PMCID: PMC2366994.
    83. Fontana L, Villareal DT, Weiss EP, Racette SB, Steger-May K, Klein S, Holloszy JO. Calorie restriction or exercise: effects on coronary heart disease risk factors. A randomized, controlled trial. Am J Physiol Endocrinol Metab. 2007 Jul; 293(1):E197-202. PMID: 17389710.
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    84. Masachessi G, Martínez LC, Giordano MO, Barril PA, Isa BM, Ferreyra L, Villareal D, Carello M, Asis C, Nates SV. Picobirnavirus (PBV) natural hosts in captivity and virus excretion pattern in infected animals. Arch Virol. 2007; 152(5):989-98. PMID: 17245535.
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    85. Villareal DT, Miller BV, Banks M, Fontana L, Sinacore DR, Klein S. Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults. Am J Clin Nutr. 2006 Dec; 84(6):1317-23. PMID: 17158411.
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    86. Villareal DT, Fontana L, Weiss EP, Racette SB, Steger-May K, Schechtman KB, Klein S, Holloszy JO. Bone mineral density response to caloric restriction-induced weight loss or exercise-induced weight loss: a randomized controlled trial. Arch Intern Med. 2006 Dec 11-25; 166(22):2502-10. PMID: 17159017.
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    87. Weiss EP, Racette SB, Villareal DT, Fontana L, Steger-May K, Schechtman KB, Klein S, Ehsani AA, Holloszy JO. Lower extremity muscle size and strength and aerobic capacity decrease with caloric restriction but not with exercise-induced weight loss. J Appl Physiol (1985). 2007 Feb; 102(2):634-40. PMID: 17095635; PMCID: PMC4376253.
    88. Weiss EP, Racette SB, Villareal DT, Fontana L, Steger-May K, Schechtman KB, Klein S, Holloszy JO. Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. Am J Clin Nutr. 2006 Nov; 84(5):1033-42. PMID: 17093155.
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    89. Racette SB, Weiss EP, Villareal DT, Arif H, Steger-May K, Schechtman KB, Fontana L, Klein S, Holloszy JO. One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue. J Gerontol A Biol Sci Med Sci. 2006 Sep; 61(9):943-50. PMID: 16960025; PMCID: PMC4376245.
    90. Villareal DT, Holloszy JO. DHEA enhances effects of weight training on muscle mass and strength in elderly women and men. Am J Physiol Endocrinol Metab. 2006 Nov; 291(5):E1003-8. PMID: 16787962.
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    91. Villareal DT, Banks M, Sinacore DR, Siener C, Klein S. Effect of weight loss and exercise on frailty in obese older adults. Arch Intern Med. 2006 Apr 24; 166(8):860-6. PMID: 16636211.
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    92. Villareal DT, Apovian CM, Kushner RF, Klein S. Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society. Obes Res. 2005 Nov; 13(11):1849-63. PMID: 16339115.
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    93. Villareal DT, Apovian CM, Kushner RF, Klein S. Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society. Am J Clin Nutr. 2005 Nov; 82(5):923-34. PMID: 16280421.
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    94. Fontana L, Shew JL, Holloszy JO, Villareal DT. Low bone mass in subjects on a long-term raw vegetarian diet. Arch Intern Med. 2005 Mar 28; 165(6):684-9. PMID: 15795346.
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    95. Evans EM, Racette SB, Peterson LR, Villareal DT, Greiwe JS, Holloszy JO. Aerobic power and insulin action improve in response to endurance exercise training in healthy 77-87 yr olds. J Appl Physiol (1985). 2005 Jan; 98(1):40-5. PMID: 15591302.
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    96. Napoli N, Villareal DT, Mumm S, Halstead L, Sheikh S, Cagaanan M, Rini GB, Armamento-Villareal R. Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density. J Bone Miner Res. 2005 Feb; 20(2):232-9. PMID: 15647817.
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    97. Villareal DT, Holloszy JO. Effect of DHEA on abdominal fat and insulin action in elderly women and men: a randomized controlled trial. JAMA. 2004 Nov 10; 292(18):2243-8. PMID: 15536111.
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    98. Spina RJ, Meyer TE, Peterson LR, Villareal DT, Rinder MR, Ehsani AA. Absence of left ventricular and arterial adaptations to exercise in octogenarians. J Appl Physiol (1985). 2004 Nov; 97(5):1654-9. PMID: 15475554.
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    99. Villareal DT, Banks M, Siener C, Sinacore DR, Klein S. Physical frailty and body composition in obese elderly men and women. Obes Res. 2004 Jun; 12(6):913-20. PMID: 15229329.
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    100. Villareal DT, Steger-May K, Schechtman KB, Yarasheski KE, Brown M, Sinacore DR, Binder EF. Effects of exercise training on bone mineral density in frail older women and men: a randomised controlled trial. Age Ageing. 2004 May; 33(3):309-12. PMID: 15082440.
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    101. Villareal DT, Grant E, Miller JP, Storandt M, McKeel DW, Morris JC. Clinical outcomes of possible versus probable Alzheimer's disease. Neurology. 2003 Sep 09; 61(5):661-7. PMID: 12963758.
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    102. Ehsani AA, Spina RJ, Peterson LR, Rinder MR, Glover KL, Villareal DT, Binder EF, Holloszy JO. Attenuation of cardiovascular adaptations to exercise in frail octogenarians. J Appl Physiol (1985). 2003 Nov; 95(5):1781-8. PMID: 12857764.
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    103. Villareal DT, Binder EF, Yarasheski KE, Williams DB, Brown M, Sinacore DR, Kohrt WM. Effects of exercise training added to ongoing hormone replacement therapy on bone mineral density in frail elderly women. J Am Geriatr Soc. 2003 Jul; 51(7):985-90. PMID: 12834519.
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    104. Peterson LR, Rinder MR, Schechtman KB, Spina RJ, Glover KL, Villareal DT, Ehsani AA. Peak exercise stroke volume: associations with cardiac structure and diastolic function. J Appl Physiol (1985). 2003 Mar; 94(3):1108-14. PMID: 12433864.
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    105. Villareal DT. Effects of dehydroepiandrosterone on bone mineral density: what implications for therapy? Treat Endocrinol. 2002; 1(6):349-57. PMID: 15832488.
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    106. Villareal DT, Binder EF, Williams DB, Schechtman KB, Yarasheski KE, Kohrt WM. Bone mineral density response to estrogen replacement in frail elderly women: a randomized controlled trial. JAMA. 2001 Aug 15; 286(7):815-20. PMID: 11497535.
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    107. Villareal DT, Holloszy JO, Kohrt WM. Effects of DHEA replacement on bone mineral density and body composition in elderly women and men. Clin Endocrinol (Oxf). 2000 Nov; 53(5):561-8. PMID: 11106916.
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    108. Villareal DT, Morris JC. The diagnosis of Alzheimer's disease. J Alzheimers Dis. 1999 Nov; 1(4-5):249-63. PMID: 12214123.
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    109. Reams G, Villareal D, Wu Z, Luger A, Knaus J, Bauer J. Glomerular function and structure in the sodium-replete and sodium-deplete uninephrectomized spontaneously hypertensive rat: effect of blood pressure reduction, glomerular structure, and blood pressure reduction. Am J Med Sci. 1995 Jan; 309(1):35-42. PMID: 7825651.
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    110. Morley JE, Kumar VB, Mattammal M, Villareal DT. Measurement of nitric oxide synthase and its mRNA in genetically obese (ob/ob) mice. Life Sci. 1995; 57(14):1327-31. PMID: 7564879.
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    111. Villareal DT, Morley JE. Trophic factors in aging. Should older people receive hormonal replacement therapy? Drugs Aging. 1994 Jun; 4(6):492-509. PMID: 8075475.
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    112. Civitelli R, Villareal DT, Armamento-Villareal R. Estrogen status and bone mass in the premenopausal period: is osteoporosis a developmental disease? J Endocrinol Invest. 1993 Nov; 16(10):829-39. PMID: 8144859.
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    113. Lacey DL, Grosso LE, Moser SA, Erdmann J, Tan HL, Pacifici R, Villareal DT. IL-1-induced murine osteoblast IL-6 production is mediated by the type 1 IL-1 receptor and is increased by 1,25 dihydroxyvitamin D3. J Clin Invest. 1993 Apr; 91(4):1731-42. PMID: 8473513; PMCID: PMC288153.
    114. Armamento-Villareal R, Villareal DT, Avioli LV, Civitelli R. Estrogen status and heredity are major determinants of premenopausal bone mass. J Clin Invest. 1992 Dec; 90(6):2464-71. PMID: 1469098; PMCID: PMC443403.
    115. Civitelli R, Villareal DT, Agnusdei D, Nardi P, Avioli LV, Gennari C. Dietary L-lysine and calcium metabolism in humans. Nutrition. 1992 Nov-Dec; 8(6):400-5. PMID: 1486246.
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    116. Villareal DT, Murphy WA, Teitelbaum SL, Arens MQ, Whyte MP. Painful diffuse osteosclerosis after intravenous drug abuse. Am J Med. 1992 Oct; 93(4):371-81. PMID: 1329508.
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    117. Villareal DT, Rupich RC, Pacifici R, Griffin MG, Maggio D, Avioli LV, Civitelli R. Effect of estrogen and calcitonin on vertebral bone density and vertebral height in osteoporotic women. Osteoporos Int. 1992 Mar; 2(2):70-3. PMID: 1536982.
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    118. Chines A, Villareal D, Pacifici R. Paget's disease of bone affecting a single vertebra: clinical, radiologic, and histopathologic correlations. Calcif Tissue Int. 1992 Feb; 50(2):115-7. PMID: 1571828.
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    119. Villareal DT, Civitelli R, Gennari C, Avioli LV. Is there an effective treatment for glucocorticoid-induced osteoporosis? Calcif Tissue Int. 1991 Aug; 49(2):141-2. PMID: 1913293.
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    120. Villareal DT, Civitelli R, Chines A, Avioli LV. Subclinical vitamin D deficiency in postmenopausal women with low vertebral bone mass. J Clin Endocrinol Metab. 1991 Mar; 72(3):628-34. PMID: 1997517.
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