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David Sheikh-Hamad

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
DivisionMedicine-Nephrology
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


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    F35HL008554     (SHEIKH-HAMAD, DAVID)Jan 9, 1991
    NIH/NHLBI
    NIH INTRAMURAL NRSA INSTITUTIONAL TRAINING PROGRAM
    Role: Principal Investigator

    I01BX000303     (SHEIKH-HAMAD, DAVID)Mar 1, 2009 - Mar 31, 2013
    VA
    Stanniocalcin-1, a novel anti-inflammatory protein
    Role: Principal Investigator

    R01DK080306     (SHEIKH-HAMAD, DAVID)Aug 1, 2009 - Jul 31, 2014
    NIH/NIDDK
    Stanniocalcin-1, a novel anti-inflammatory protein
    Role: Principal Investigator

    I01BX002006     (SHEIKH-HAMAD, DAVID)Apr 1, 2014 - Dec 31, 2022
    VA
    Stanniocalcin-1: New paradigms for cytoprotection and anti-inflammation
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zou D, Ganugula R, Arora M, Nabity MB, Sheikh-Hamad D, Kumar MNVR. Oral delivery of nanoparticle urolithin A normalizes cellular stress and improves survival in mouse model of cisplatin-induced AKI. Am J Physiol Renal Physiol. 2019 Nov 01; 317(5):F1255-F1264. PMID: 31532243.
      View in: PubMed
    2. Dalvin LA, Hartnett ME, Bretz CA, Hann CR, Cui RZ, Marmorstein AD, Sheikh-Hamad D, Fautsch MP, Roddy GW. Stanniocalcin-1 is a Modifier of Oxygen-Induced Retinopathy Severity. Curr Eye Res. 2020 Jan; 45(1):46-51. PMID: 31314602.
      View in: PubMed
    3. Rafique Z, Aceves J, Espina I, Peacock F, Sheikh-Hamad D, Kuo D. Can physicians detect hyperkalemia based on the electrocardiogram? Am J Emerg Med. 2019 Apr 22. PMID: 31047740.
      View in: PubMed
    4. Pan JS, Sheikh-Hamad D. Mitochondrial dysfunction in acute kidney injury and sex-specific implications. Med Res Arch. 2019 02; 7(2). PMID: 31276028.
      View in: PubMed
    5. Lin L, Lee JH, Wang R, Wang R, Sheikh-Hamad D, Zang QS, Sun Y. aP2-Cre Mediated Ablation of GHS-R Attenuates Adiposity and Improves Insulin Sensitivity during Aging. Int J Mol Sci. 2018 Oct 01; 19(10). PMID: 30275401.
      View in: PubMed
    6. Li Q, Lei F, Tang Y, Pan JS, Tong Q, Sun Y, Sheikh-Hamad D. Megalin mediates plasma membrane to mitochondria cross-talk and regulates mitochondrial metabolism. Cell Mol Life Sci. 2018 Nov; 75(21):4021-4040. PMID: 29916093.
      View in: PubMed
    7. Mindikoglu AL, Opekun AR, Putluri N, Devaraj S, Sheikh-Hamad D, Vierling JM, Goss JA, Rana A, Sood GK, Jalal PK, Inker LA, Mohney RP, Tighiouart H, Christenson RH, Dowling TC, Weir MR, Seliger SL, Hutson WR, Howell CD, Raufman JP, Magder LS, Coarfa C. Unique metabolomic signature associated with hepatorenal dysfunction and mortality in cirrhosis. Transl Res. 2018 05; 195:25-47. PMID: 29291380.
      View in: PubMed
    8. Roddy GW, Viker KB, Winkler NS, Bahler CK, Holman BH, Sheikh-Hamad D, Roy Chowdhury U, Stamer WD, Fautsch MP. Stanniocalcin-1 Is an Ocular Hypotensive Agent and a Downstream Effector Molecule That Is Necessary for the Intraocular Pressure-Lowering Effects of Latanoprost. Invest Ophthalmol Vis Sci. 2017 05 01; 58(5):2715-2724. PMID: 28538979.
      View in: PubMed
    9. Glaser J, Lemery J, Rajagopalan B, Diaz HF, García-Trabanino R, Taduri G, Madero M, Amarasinghe M, Abraham G, Anutrakulchai S, Jha V, Stenvinkel P, Roncal-Jimenez C, Lanaspa MA, Correa-Rotter R, Sheikh-Hamad D, Burdmann EA, Andres-Hernando A, Milagres T, Weiss I, Kanbay M, Wesseling C, Sánchez-Lozada LG, Johnson RJ. Climate Change and the Emergent Epidemic of CKD from Heat Stress in Rural Communities: The Case for Heat Stress Nephropathy. Clin J Am Soc Nephrol. 2016 08 08; 11(8):1472-83. PMID: 27151892.
      View in: PubMed
    10. Lin L, Lee JH, Buras ED, Yu K, Wang R, Smith CW, Wu H, Sheikh-Hamad D, Sun Y. Ghrelin receptor regulates adipose tissue inflammation in aging. Aging (Albany NY). 2016 Jan; 8(1):178-91. PMID: 26837433.
      View in: PubMed
    11. Huang L, Zhang L, Ju H, Li Q, Pan JS, Al-Lawati Z, Sheikh-Hamad D. Stanniocalcin-1 inhibits thrombin-induced signaling and protects from bleomycin-induced lung injury. Sci Rep. 2015 Dec 07; 5:18117. PMID: 26640170.
      View in: PubMed
    12. Pan JS, Sheikh-Hamad D. Remote Ischemic Preconditioning and Postoperative Renal Dysfunction--Reply. JAMA. 2015 Oct 13; 314(14):1520. PMID: 26462007.
      View in: PubMed
    13. Huang L, Lou Y, Ju H, Zhang L, Pan JS, Ross A, Sun Y, Truong LD, Sheikh-Hamad D. Severe Nephrotoxic Nephritis following Conditional and Kidney-Specific Knockdown of Stanniocalcin-1. PLoS One. 2015; 10(9):e0138440. PMID: 26393521.
      View in: PubMed
    14. Pan JS, Sheikh-Hamad D. Remote ischemic preconditioning for kidney protection. JAMA. 2015 Jun 02; 313(21):2124-5. PMID: 26024384.
      View in: PubMed
    15. Scherzer P, Gal-Moscovici A, Sheikh-Hamad D, Popovtzer MM. Sodium-pump gene-expression, protein abundance and enzyme activity in isolated nephron segments of the aging rat kidney. Physiol Rep. 2015 Jun; 3(6). PMID: 26056060.
      View in: PubMed
    16. Lin L, Lee JH, Bongmba OY, Ma X, Zhu X, Sheikh-Hamad D, Sun Y. The suppression of ghrelin signaling mitigates age-associated thermogenic impairment. Aging (Albany NY). 2014 Dec; 6(12):1019-32. PMID: 25543537.
      View in: PubMed
    17. Pan JS, Huang L, Belousova T, Lu L, Yang Y, Reddel R, Chang A, Ju H, DiMattia G, Tong Q, Sheikh-Hamad D. Stanniocalcin-1 inhibits renal ischemia/reperfusion injury via an AMP-activated protein kinase-dependent pathway. J Am Soc Nephrol. 2015 Feb; 26(2):364-78. PMID: 25012175.
      View in: PubMed
    18. Huang L, Belousova T, Pan JS, Du J, Ju H, Lu L, Zhang P, Truong LD, Nuotio-Antar A, Sheikh-Hamad D. AKI after conditional and kidney-specific knockdown of stanniocalcin-1. J Am Soc Nephrol. 2014 Oct; 25(10):2303-15. PMID: 24700878.
      View in: PubMed
    19. Sheikh-Hamad D. From TOR and SMAD, why HIF-1a can be bad. Am J Physiol Renal Physiol. 2014 Jan; 306(2):F170-1. PMID: 24049143.
      View in: PubMed
    20. Huang L, Belousova T, Chen M, DiMattia G, Liu D, Sheikh-Hamad D. Overexpression of stanniocalcin-1 inhibits reactive oxygen species and renal ischemia/reperfusion injury in mice. Kidney Int. 2012 Oct; 82(8):867-77. PMID: 22695329.
      View in: PubMed
    21. Liu D, Huang L, Wang Y, Wang W, Wehrens XH, Belousova T, Abdelrahim M, DiMattia G, Sheikh-Hamad D. Human stanniocalcin-1 suppresses angiotensin II-induced superoxide generation in cardiomyocytes through UCP3-mediated anti-oxidant pathway. PLoS One. 2012; 7(5):e36994. PMID: 22693564.
      View in: PubMed
    22. Kagan A, Sheikh-Hamad D. Contrast-induced kidney injury: focus on modifiable risk factors and prophylactic strategies. Clin Cardiol. 2010 Feb; 33(2):62-6. PMID: 20186983.
      View in: PubMed
    23. Colon J, Basha MR, Madero-Visbal R, Konduri S, Baker CH, Herrera LJ, Safe S, Sheikh-Hamad D, Abudayyeh A, Alvarado B, Abdelrahim M. Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice. Invest New Drugs. 2011 Feb; 29(1):41-51. PMID: 19851711.
      View in: PubMed
    24. Sheikh-Hamad D. Mammalian stanniocalcin-1 activates mitochondrial antioxidant pathways: new paradigms for regulation of macrophages and endothelium. Am J Physiol Renal Physiol. 2010 Feb; 298(2):F248-54. PMID: 19656913.
      View in: PubMed
    25. Wang Y, Huang L, Abdelrahim M, Cai Q, Truong A, Bick R, Poindexter B, Sheikh-Hamad D. Stanniocalcin-1 suppresses superoxide generation in macrophages through induction of mitochondrial UCP2. J Leukoc Biol. 2009 Oct; 86(4):981-8. PMID: 19602668.
      View in: PubMed
    26. Huang L, Garcia G, Lou Y, Zhou Q, Truong LD, DiMattia G, Lan XR, Lan HY, Wang Y, Sheikh-Hamad D. Anti-inflammatory and renal protective actions of stanniocalcin-1 in a model of anti-glomerular basement membrane glomerulonephritis. Am J Pathol. 2009 Apr; 174(4):1368-78. PMID: 19246645.
      View in: PubMed
    27. Stephen MJ, Poindexter BJ, Moolman JA, Sheikh-Hamad D, Bick RJ. Do binucleate cardiomyocytes have a role in myocardial repair? Insights using isolated rodent myocytes and cell culture. Open Cardiovasc Med J. 2009; 3:1-7. PMID: 19430572.
      View in: PubMed
    28. Sheikh-Hamad D. Cisplatin-induced cytoxicity: is the nucleus relevant? Am J Physiol Renal Physiol. 2008 Jul; 295(1):F42-3. PMID: 18480173.
      View in: PubMed
    29. Chen C, Jamaluddin MS, Yan S, Sheikh-Hamad D, Yao Q. Human stanniocalcin-1 blocks TNF-alpha-induced monolayer permeability in human coronary artery endothelial cells. Arterioscler Thromb Vasc Biol. 2008 May; 28(5):906-12. PMID: 18309109.
      View in: PubMed
    30. Sheikh-Hamad D, Paiuk E, Wright AJ, Kleinmann C, Khosla U, Shandera WX. Care for immigrants with end-stage renal disease in Houston: a comparison of two practices. Tex Med. 2007 Apr; 103(4):54-8, 53. PMID: 17494250.
      View in: PubMed
    31. Abdelrahim M, Baker CH, Abbruzzese JL, Sheikh-Hamad D, Liu S, Cho SD, Yoon K, Safe S. Regulation of vascular endothelial growth factor receptor-1 expression by specificity proteins 1, 3, and 4 in pancreatic cancer cells. Cancer Res. 2007 Apr 01; 67(7):3286-94. PMID: 17409437.
      View in: PubMed
    32. Chakraborty A, Brooks H, Zhang P, Smith W, McReynolds MR, Hoying JB, Bick R, Truong L, Poindexter B, Lan H, Elbjeirami W, Sheikh-Hamad D. Stanniocalcin-1 regulates endothelial gene expression and modulates transendothelial migration of leukocytes. Am J Physiol Renal Physiol. 2007 Feb; 292(2):F895-904. PMID: 17032941.
      View in: PubMed
    33. Padda R, Wamsley-Davis A, Gustin MC, Ross R, Yu C, Sheikh-Hamad D. MEKK3-mediated signaling to p38 kinase and TonE in hypertonically stressed kidney cells. Am J Physiol Renal Physiol. 2006 Oct; 291(4):F874-81. PMID: 16684924.
      View in: PubMed
    34. Sule N, Yakupoglu U, Shen SS, Krishnan B, Yang G, Lerner S, Sheikh-Hamad D, Truong LD. Calcium oxalate deposition in renal cell carcinoma associated with acquired cystic kidney disease: a comprehensive study. Am J Surg Pathol. 2005 Apr; 29(4):443-51. PMID: 15767796.
      View in: PubMed
    35. Hou CC, Wang W, Huang XR, Fu P, Chen TH, Sheikh-Hamad D, Lan HY. Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidney. Am J Pathol. 2005 Mar; 166(3):761-71. PMID: 15743788.
      View in: PubMed
    36. Sheikh-Hamad D, Gustin MC. MAP kinases and the adaptive response to hypertonicity: functional preservation from yeast to mammals. Am J Physiol Renal Physiol. 2004 Dec; 287(6):F1102-10. PMID: 15522988.
      View in: PubMed
    37. Truong LD, Yakupoglu U, Feig D, Hicks J, Cartwight J, Sheikh-Hamad D, Suki WN. Calcium oxalate deposition in renal allografts: morphologic spectrum and clinical implications. Am J Transplant. 2004 Aug; 4(8):1338-44. PMID: 15268737.
      View in: PubMed
    38. Wamsley-Davis A, Padda R, Truong LD, Tsao CC, Zhang P, Sheikh-Hamad D. AT1A-mediated activation of kidney JNK1 and SMAD2 in obstructive uropathy: preservation of kidney tissue mass using candesartan. Am J Physiol Renal Physiol. 2004 Sep; 287(3):F474-80. PMID: 15126250.
      View in: PubMed
    39. Kanellis J, Bick R, Garcia G, Truong L, Tsao CC, Etemadmoghadam D, Poindexter B, Feng L, Johnson RJ, Sheikh-Hamad D. Stanniocalcin-1, an inhibitor of macrophage chemotaxis and chemokinesis. Am J Physiol Renal Physiol. 2004 Feb; 286(2):F356-62. PMID: 14570698.
      View in: PubMed
    40. Sheikh-Hamad D, Cacini W, Buckley AR, Isaac J, Truong LD, Tsao CC, Kishore BK. Cellular and molecular studies on cisplatin-induced apoptotic cell death in rat kidney. Arch Toxicol. 2004 Mar; 78(3):147-55. PMID: 14551673.
      View in: PubMed
    41. Kanellis J, Watanabe S, Li JH, Kang DH, Li P, Nakagawa T, Wamsley A, Sheikh-Hamad D, Lan HY, Feng L, Johnson RJ. Uric acid stimulates monocyte chemoattractant protein-1 production in vascular smooth muscle cells via mitogen-activated protein kinase and cyclooxygenase-2. Hypertension. 2003 Jun; 41(6):1287-93. PMID: 12743010.
      View in: PubMed
    42. Mai HL, Sheikh-Hamad D, Herrera GA, Gu X, Truong LD. Immunoglobulin heavy chain can be amyloidogenic: morphologic characterization including immunoelectron microscopy. Am J Surg Pathol. 2003 Apr; 27(4):541-5. PMID: 12657941.
      View in: PubMed
    43. Sheikh-Hamad D, Bick R, Wu GY, Christensen BM, Razeghi P, Poindexter B, Taegtmeyer H, Wamsley A, Padda R, Entman M, Nielsen S, Youker K. Stanniocalcin-1 is a naturally occurring L-channel inhibitor in cardiomyocytes: relevance to human heart failure. Am J Physiol Heart Circ Physiol. 2003 Jul; 285(1):H442-8. PMID: 12663264.
      View in: PubMed
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