TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
AddressOne Baylor Plaza
Houston, TX 77030
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    U01HD076596     (LONARD, DAVID M)Aug 24, 2012 - Jun 30, 2017
    Small Molecule Src-2 Antagonists as Regulators of Sertoli Cell Function and Male
    Role: Principal Investigator

    R41CA217561     (LONARD, DAVID M)Sep 1, 2018 - Aug 31, 2019
    Small molecule Inhibitors of steroid receptor coactivator to treat breast cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Qin L, Chen J, Lu D, Jain P, Yu Y, Cardenas D, Peng X, Yu X, Xu J, Wang J, O'Malley BW, Lonard DM. Development of improved SRC-3 inhibitors as breast cancer therapeutic agents. Endocr Relat Cancer. 2021 Aug 13; 28(10):657-670. PMID: 34310341.
      Citations:    Fields:    
    2. Gilad Y, Eliaz Y, Yu Y, Dean AM, Han SJ, Qin L, O'Malley BW, Lonard DM. A genome-scale CRISPR Cas9 dropout screen identifies synthetically lethal targets in SRC-3 inhibited cancer cells. Commun Biol. 2021 03 25; 4(1):399. PMID: 33767353.
      Citations:    Translation:HumansCells
    3. Mullany LK, Lonard DM, O'Malley BW. Wound Healing-related Functions of the p160 Steroid Receptor Coactivator Family. Endocrinology. 2021 03 01; 162(3). PMID: 33340403.
      Citations:    Fields:    Translation:HumansAnimalsCells
    4. Liu J, Xie Y, Guo J, Li X, Wang J, Jiang H, Peng Z, Wang J, Wang S, Li Q, Ye L, Zhong Y, Zhang Q, Liu X, Lonard DM, Wang J, O'Malley BW, Liu Z. Targeting NSD2-mediated SRC-3 liquid-liquid phase separation sensitizes bortezomib treatment in multiple myeloma. Nat Commun. 2021 02 15; 12(1):1022. PMID: 33589584.
      Citations: 2     Fields:    Translation:HumansCells
    5. Nikolai BC, Jain P, Cardenas DL, York B, Feng Q, McKenna NJ, Dasgupta S, Lonard DM, O'Malley BW. Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs. Sci Rep. 2021 02 09; 11(1):3441. PMID: 33564037.
      Citations: 1     Fields:    
    6. Gilad Y, Gellerman G, Lonard DM, O'Malley BW. Drug Combination in Cancer Treatment-From Cocktails to Conjugated Combinations. Cancers (Basel). 2021 Feb 07; 13(4). PMID: 33562300.
      Citations: 2     
    7. Rohira AD, Lonard DM, O'Malley BW. Emerging roles of steroid receptor coactivators in stromal cell responses. J Endocrinol. 2021 02; 248(2):R41-R50. PMID: 33337343.
      Citations:    Fields:    Translation:HumansAnimalsCells
    8. Meng H, Gonzales NM, Lonard DM, Putluri N, Zhu B, Dacso CC, York B, O'Malley BW. XBP1 links the 12-hour clock to NAFLD and regulation of membrane fluidity and lipid homeostasis. Nat Commun. 2020 12 04; 11(1):6215. PMID: 33277471.
      Citations: 3     Fields:    Translation:HumansAnimals
    9. Mullany LK, Rohira AD, Leach JP, Kim JH, Monroe TO, Ortiz AR, Stork B, Gaber MW, Sarkar P, Sikora AG, Rosengart TK, York B, Song Y, Dacso CC, Lonard DM, Martin JF, O'Malley BW. A steroid receptor coactivator stimulator (MCB-613) attenuates adverse remodeling after myocardial infarction. Proc Natl Acad Sci U S A. 2020 12 08; 117(49):31353-31364. PMID: 33229578.
      Citations: 2     Fields:    Translation:AnimalsCells
    10. Gao X, Wang Q, Wang Y, Liu J, Liu S, Liu J, Zhou X, Zhou L, Chen H, Pan L, Chen J, Wang D, Zhang Q, Shen S, Xiao Y, Wu Z, Cheng Y, Chen G, Kubra S, Qin J, Huang L, Zhang P, Wang C, Moses RE, Lonard DM, O' Malley BW, Fares F, Zhang B, Li X, Li L, Xiao J. Author Correction: The REG? inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells. Nat Commun. 2020 Sep 23; 11(1):4888. PMID: 32968062.
      Citations:    Fields:    
    11. Gao X, Wang Q, Wang Y, Liu J, Liu S, Liu J, Zhou X, Zhou L, Chen H, Pan L, Chen J, Wang D, Zhang Q, Shen S, Xiao Y, Wu Z, Cheng Y, Chen G, Kubra S, Qin J, Huang L, Zhang P, Wang C, Moses RE, Lonard DM, Malley BWO, Fares F, Zhang B, Li X, Li L, Xiao J. The REG? inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells. Nat Commun. 2020 08 06; 11(1):3904. PMID: 32764536.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    12. Lee WK, Kim WG, Fozzatti L, Park S, Zhao L, Willingham MC, Lonard D, O'Malley BW, Cheng SY. Steroid receptor coactivator-3 as a target for anaplastic thyroid cancer. Endocr Relat Cancer. 2020 04; 27(4):209-220. PMID: 31977311.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    13. Gilad Y, Eliaz Y, Yu Y, Han SJ, O'Malley BW, Lonard DM. Author Correction: Drug-induced PD-L1 expression and cell stress response in breast cancer cells can be balanced by drug combination. Sci Rep. 2020 Mar 05; 10(1):4463. PMID: 32132607.
      Citations: 2     Fields:    
    14. Gilad Y, Eliaz Y, Yu Y, Han SJ, O'Malley BW, Lonard DM. Drug-induced PD-L1 expression and cell stress response in breast cancer cells can be balanced by drug combination. Sci Rep. 2019 10 22; 9(1):15099. PMID: 31641154.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    15. Hai L, Szwarc MM, Lonard DM, Rajapakshe K, Perera D, Coarfa C, Ittmann M, Fernandez-Valdivia R, Lydon JP. Short-term RANKL exposure initiates a neoplastic transcriptional program in the basal epithelium of the murine salivary gland. Cytokine. 2019 11; 123:154745. PMID: 31226438.
      Citations:    Fields:    Translation:AnimalsCells
    16. Song X, Chen H, Zhang C, Yu Y, Chen Z, Liang H, Van Buren G, McElhany AL, Fisher WE, Lonard DM, O'Malley BW, Wang J. SRC-3 inhibition blocks tumor growth of pancreatic ductal adenocarcinoma. Cancer Lett. 2019 02 01; 442:310-319. PMID: 30423406.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    17. Hai L, Szwarc MM, He B, Lonard DM, Kommagani R, DeMayo FJ, Lydon JP. Uterine function in the mouse requires speckle-type poz protein. Biol Reprod. 2018 06 01; 98(6):856-869. PMID: 29546395.
      Citations: 4     Fields:    Translation:Animals
    18. Panigrahi AK, Foulds CE, Lanz RB, Hamilton RA, Yi P, Lonard DM, Tsai MJ, Tsai SY, O'Malley BW. SRC-3 Coactivator Governs Dynamic Estrogen-Induced Chromatin Looping Interactions during Transcription. Mol Cell. 2018 05 17; 70(4):679-694.e7. PMID: 29775582.
      Citations: 13     Fields:    Translation:HumansCells
    19. Gates LA, Gu G, Chen Y, Rohira AD, Lei JT, Hamilton RA, Yu Y, Lonard DM, Wang J, Wang SP, Edwards DG, Lavere PF, Shao J, Yi P, Jain A, Jung SY, Malovannaya A, Li S, Shao J, Roeder RG, Ellis MJ, Qin J, Fuqua SAW, O'Malley BW, Foulds CE. Proteomic profiling identifies key coactivators utilized by mutant ERa proteins as potential new therapeutic targets. Oncogene. 2018 08; 37(33):4581-4598. PMID: 29748621.
      Citations: 22     Fields:    Translation:HumansCells
    20. Padmanabhan A, Candelaria N, Wong KK, Nikolai BC, Lonard DM, O'Malley BW, Richards JS. USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells. Nat Commun. 2018 03 28; 9(1):1270. PMID: 29593334.
      Citations: 23     Fields:    Translation:HumansCells
    21. Szwarc MM, Hai L, Gibbons WE, Peavey MC, White LD, Mo Q, Lonard DM, Kommagani R, Lanz RB, DeMayo FJ, Lydon JP. Human endometrial stromal cell decidualization requires transcriptional reprogramming by PLZF. Biol Reprod. 2018 01 01; 98(1):15-27. PMID: 29186366.
      Citations: 6     Fields:    Translation:HumansCells
    22. Rohira AD, Yan F, Wang L, Wang J, Zhou S, Lu A, Yu Y, Xu J, Lonard DM, O'Malley BW. Targeting SRC Coactivators Blocks the Tumor-Initiating Capacity of Cancer Stem-like Cells. Cancer Res. 2017 08 15; 77(16):4293-4304. PMID: 28611048.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    23. Rohira AD, Lonard DM. Steroid receptor coactivators present a unique opportunity for drug development in hormone-dependent cancers. Biochem Pharmacol. 2017 09 15; 140:1-7. PMID: 28390937.
      Citations: 12     Fields:    Translation:HumansCells
    24. Szwarc MM, Kommagani R, Peavey MC, Hai L, Lonard DM, Lydon JP. A bioluminescence reporter mouse that monitors expression of constitutively active ß-catenin. PLoS One. 2017; 12(3):e0173014. PMID: 28253313.
      Citations: 2     Fields:    Translation:AnimalsCells
    25. Lonard DM, O'Malley BW. Molecular Pathways: Targeting Steroid Receptor Coactivators in Cancer. Clin Cancer Res. 2016 Nov 15; 22(22):5403-5407. PMID: 27654711.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    26. Wang L, Lonard DM, O'Malley BW. The Role of Steroid Receptor Coactivators in Hormone Dependent Cancers and Their Potential as Therapeutic Targets. Horm Cancer. 2016 08; 7(4):229-35. PMID: 27125199.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    27. Song X, Chen J, Zhao M, Zhang C, Yu Y, Lonard DM, Chow DC, Palzkill T, Xu J, O'Malley BW, Wang J. Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3. Proc Natl Acad Sci U S A. 2016 May 03; 113(18):4970-5. PMID: 27084884.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    28. Nikolai BC, Lanz RB, York B, Dasgupta S, Mitsiades N, Creighton CJ, Tsimelzon A, Hilsenbeck SG, Lonard DM, Smith CL, O'Malley BW. HER2 Signaling Drives DNA Anabolism and Proliferation through SRC-3 Phosphorylation and E2F1-Regulated Genes. Cancer Res. 2016 Mar 15; 76(6):1463-75. PMID: 26833126.
      Citations: 14     Fields:    Translation:HumansCells
    29. Song X, Zhang C, Zhao M, Chen H, Liu X, Chen J, Lonard DM, Qin L, Xu J, Wang X, Li F, O'Malley BW, Wang J. Steroid Receptor Coactivator-3 (SRC-3/AIB1) as a Novel Therapeutic Target in Triple Negative Breast Cancer and Its Inhibition with a Phospho-Bufalin Prodrug. PLoS One. 2015; 10(10):e0140011. PMID: 26431029.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    30. Wang L, Yu Y, Chow DC, Yan F, Hsu CC, Stossi F, Mancini MA, Palzkill T, Liao L, Zhou S, Xu J, Lonard DM, O'Malley BW. Characterization of a Steroid Receptor Coactivator Small Molecule Stimulator that Overstimulates Cancer Cells and Leads to Cell Stress and Death. Cancer Cell. 2015 Aug 10; 28(2):240-52. PMID: 26267537.
      Citations: 43     Fields:    Translation:HumansCells
    31. Ma G, He J, Yu Y, Xu Y, Yu X, Martinez J, Lonard DM, Xu J. Tamoxifen inhibits ER-negative breast cancer cell invasion and metastasis by accelerating Twist1 degradation. Int J Biol Sci. 2015; 11(5):618-28. PMID: 25892968.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    32. Kang YK, Putluri N, Maity S, Tsimelzon A, Ilkayeva O, Mo Q, Lonard D, Michailidis G, Sreekumar A, Newgard CB, Wang M, Tsai SY, Tsai MJ, O'Malley BW. CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-a-Gabpa and stress-induced adaptive responses via NF-?B-cMYC. PLoS Genet. 2015 Apr; 11(4):e1005116. PMID: 25830341.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    33. Lonard DM, Xu J, O'Malley BW. Bufalin is a steroid receptor coactivator inhibitor-response. Cancer Res. 2015 Mar 15; 75(6):1157. PMID: 25736684.
      Citations: 2     Fields:    Translation:HumansAnimals
    34. Yan F, Yu Y, Chow DC, Palzkill T, Madoux F, Hodder P, Chase P, Griffin PR, O'Malley BW, Lonard DM. Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor. PLoS One. 2014; 9(4):e95243. PMID: 24743578.
      Citations: 18     Fields:    Translation:HumansCells
    35. Motamed M, Rajapakshe KI, Hartig SM, Coarfa C, Moses RE, Lonard DM, O'Malley BW. Steroid receptor coactivator 1 is an integrator of glucose and NAD+/NADH homeostasis. Mol Endocrinol. 2014 Mar; 28(3):395-405. PMID: 24438340.
      Citations: 8     Fields:    Translation:HumansCells
    36. Wang Y, Lonard DM, Yu Y, Chow DC, Palzkill TG, Wang J, Qi R, Matzuk AJ, Song X, Madoux F, Hodder P, Chase P, Griffin PR, Zhou S, Liao L, Xu J, O'Malley BW. Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1. Cancer Res. 2014 Mar 01; 74(5):1506-1517. PMID: 24390736.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    37. Dasgupta S, Lonard DM, O'Malley BW. Nuclear receptor coactivators: master regulators of human health and disease. Annu Rev Med. 2014; 65:279-92. PMID: 24111892.
      Citations: 78     Fields:    Translation:HumansCells
    38. Foulds CE, Feng Q, Ding C, Bailey S, Hunsaker TL, Malovannaya A, Hamilton RA, Gates LA, Zhang Z, Li C, Chan D, Bajaj A, Callaway CG, Edwards DP, Lonard DM, Tsai SY, Tsai MJ, Qin J, O'Malley BW. Proteomic analysis of coregulators bound to ERa on DNA and nucleosomes reveals coregulator dynamics. Mol Cell. 2013 Jul 25; 51(2):185-99. PMID: 23850489.
      Citations: 65     Fields:    Translation:HumansCells
    39. Geng C, He B, Xu L, Barbieri CE, Eedunuri VK, Chew SA, Zimmermann M, Bond R, Shou J, Li C, Blattner M, Lonard DM, Demichelis F, Coarfa C, Rubin MA, Zhou P, O'Malley BW, Mitsiades N. Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6997-7002. PMID: 23559371.
      Citations: 110     Fields:    Translation:HumansCells
    40. Yi P, Xia W, Wu RC, Lonard DM, Hung MC, O'Malley BW. SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization. Genes Dev. 2013 Feb 01; 27(3):274-87. PMID: 23388826.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    41. Lonard DM, O'Malley BW. Nuclear receptor coregulators: modulators of pathology and therapeutic targets. Nat Rev Endocrinol. 2012 Oct; 8(10):598-604. PMID: 22733267.
      Citations: 103     Fields:    Translation:HumansAnimals
    42. Long W, Foulds CE, Qin J, Liu J, Ding C, Lonard DM, Solis LM, Wistuba II, Qin J, Tsai SY, Tsai MJ, O'Malley BW. ERK3 signals through SRC-3 coactivator to promote human lung cancer cell invasion. J Clin Invest. 2012 May; 122(5):1869-80. PMID: 22505454.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    43. Wang Y, Lonard DM, Yu Y, Chow DC, Palzkill TG, O'Malley BW. Small molecule inhibition of the steroid receptor coactivators, SRC-3 and SRC-1. Mol Endocrinol. 2011 Dec; 25(12):2041-53. PMID: 22053001.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    44. Luo Z, Xu X, Gu P, Lonard D, Gunaratne PH, Cooney AJ, Azencott R. miRNA regulatory circuits in ES cells differentiation: a chemical kinetics modeling approach. PLoS One. 2011; 6(10):e23263. PMID: 22039400.
      Citations: 4     Fields:    Translation:AnimalsCells
    45. Li C, Ao J, Fu J, Lee DF, Xu J, Lonard D, O'Malley BW. Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1. Oncogene. 2011 Oct 20; 30(42):4350-64. PMID: 21577200.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    46. Liu J, Yu G, Zhao Y, Zhao D, Wang Y, Wang L, Liu J, Li L, Zeng Y, Dang Y, Wang C, Gao G, Long W, Lonard DM, Qiao S, Tsai MJ, Zhang B, Luo H, Li X. REGgamma modulates p53 activity by regulating its cellular localization. J Cell Sci. 2010 Dec 01; 123(Pt 23):4076-84. PMID: 21084564.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    47. Yu G, Zhao Y, He J, Lonard DM, Mao CA, Wang G, Li M, Li X. Comparative analysis of REG{gamma} expression in mouse and human tissues. J Mol Cell Biol. 2010 Aug; 2(4):192-8. PMID: 20494959.
      Citations: 11     Fields:    Translation:HumansAnimals
    48. Stanisic V, Lonard DM, O'Malley BW. Modulation of steroid hormone receptor activity. Prog Brain Res. 2010; 181:153-76. PMID: 20478437.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    49. Stanišic V, Lonard DM, O'Malley BW. Estrogen receptor-a: molecular mechanisms and interactions with the ubiquitin proteasome system. Horm Mol Biol Clin Investig. 2010 Jan; 1(1):1-9. PMID: 25961966.
      Citations: 1     Fields:    
    50. Lonard DM, Kumar R, O'Malley BW. Minireview: the SRC family of coactivators: an entrée to understanding a subset of polygenic diseases? Mol Endocrinol. 2010 Feb; 24(2):279-85. PMID: 19846539.
      Citations: 19     Fields:    Translation:HumansAnimals
    51. Lonard DM, O'Malley BW. Emerging roles of the ubiquitin proteasome system in nuclear hormone receptor signaling. Prog Mol Biol Transl Sci. 2009; 87:117-35. PMID: 20374703.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    52. Stanišic V, Malovannaya A, Qin J, Lonard DM, O'Malley BW. OTU Domain-containing ubiquitin aldehyde-binding protein 1 (OTUB1) deubiquitinates estrogen receptor (ER) alpha and affects ERalpha transcriptional activity. J Biol Chem. 2009 Jun 12; 284(24):16135-16145. PMID: 19383985.
      Citations: 34     Fields:    Translation:HumansCells
    53. Han SJ, Lonard DM, O'Malley BW. Multi-modulation of nuclear receptor coactivators through posttranslational modifications. Trends Endocrinol Metab. 2009 Jan; 20(1):8-15. PMID: 19019695.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    54. Lonard DM, O'Malley BW. Gene transcription: two worlds merged. Nature. 2008 Apr 24; 452(7190):946-7. PMID: 18432236.
      Citations: 3     Fields:    Translation:Cells
    55. Lonard DM, O'Malley BW. SRC-3 transcription-coupled activation, degradation, and the ubiquitin clock: is there enough coactivator to go around in cells? Sci Signal. 2008 Apr 01; 1(13):pe16. PMID: 18385039.
      Citations: 22     Fields:    Translation:HumansCells
    56. Yi P, Feng Q, Amazit L, Lonard DM, Tsai SY, Tsai MJ, O'Malley BW. Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1. Mol Cell. 2008 Feb 29; 29(4):465-76. PMID: 18313384.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    57. He B, Feng Q, Mukherjee A, Lonard DM, DeMayo FJ, Katzenellenbogen BS, Lydon JP, O'Malley BW. A repressive role for prohibitin in estrogen signaling. Mol Endocrinol. 2008 Feb; 22(2):344-60. PMID: 17932104.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    58. Lonard DM, O'malley BW. Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation. Mol Cell. 2007 Sep 07; 27(5):691-700. PMID: 17803935.
      Citations: 189     Fields:    Translation:HumansCells
    59. Lonard DM, Lanz RB, O'Malley BW. Nuclear receptor coregulators and human disease. Endocr Rev. 2007 Aug; 28(5):575-87. PMID: 17609497.
      Citations: 130     Fields:    Translation:HumansAnimals
    60. Li X, Amazit L, Long W, Lonard DM, Monaco JJ, O'Malley BW. Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathway. Mol Cell. 2007 Jun 22; 26(6):831-42. PMID: 17588518.
      Citations: 124     Fields:    Translation:HumansAnimalsCells
    61. Wu RC, Feng Q, Lonard DM, O'Malley BW. SRC-3 coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock. Cell. 2007 Jun 15; 129(6):1125-40. PMID: 17574025.
      Citations: 118     Fields:    Translation:HumansCells
    62. Lonard DM, O'Malley BW. The expanding cosmos of nuclear receptor coactivators. Cell. 2006 May 05; 125(3):411-4. PMID: 16678083.
      Citations: 122     Fields:    Translation:HumansAnimalsCells
    63. Li X, Lonard DM, Jung SY, Malovannaya A, Feng Q, Qin J, Tsai SY, Tsai MJ, O'Malley BW. The SRC-3/AIB1 coactivator is degraded in a ubiquitin- and ATP-independent manner by the REGgamma proteasome. Cell. 2006 Jan 27; 124(2):381-92. PMID: 16439211.
      Citations: 115     Fields:    Translation:HumansAnimalsCells
    64. Lonard DM, O'Malley BW. Expanding functional diversity of the coactivators. Trends Biochem Sci. 2005 Mar; 30(3):126-32. PMID: 15752984.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    65. Dennis AP, Lonard DM, Nawaz Z, O'Malley BW. Inhibition of the 26S proteasome blocks progesterone receptor-dependent transcription through failed recruitment of RNA polymerase II. J Steroid Biochem Mol Biol. 2005 Mar; 94(4):337-46. PMID: 15857753.
      Citations: 26     Fields:    Translation:HumansCells
    66. Li X, Lonard DM, O'Malley BW. A contemporary understanding of progesterone receptor function. Mech Ageing Dev. 2004 Oct-Nov; 125(10-11):669-78. PMID: 15541762.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    67. Lonard DM, Tsai SY, O'Malley BW. Selective estrogen receptor modulators 4-hydroxytamoxifen and raloxifene impact the stability and function of SRC-1 and SRC-3 coactivator proteins. Mol Cell Biol. 2004 Jan; 24(1):14-24. PMID: 14673139.
      Citations: 28     Fields:    Translation:HumansCells
    68. Yan F, Gao X, Lonard DM, Nawaz Z. Specific ubiquitin-conjugating enzymes promote degradation of specific nuclear receptor coactivators. Mol Endocrinol. 2003 Jul; 17(7):1315-31. PMID: 12663742.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    69. Cavarretta IT, Mukopadhyay R, Lonard DM, Cowsert LM, Bennett CF, O'Malley BW, Smith CL. Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation. Mol Endocrinol. 2002 Feb; 16(2):253-70. PMID: 11818499.
      Citations: 25     Fields:    Translation:HumansCells
    70. Lonard DM, Smith CL. Molecular perspectives on selective estrogen receptor modulators (SERMs): progress in understanding their tissue-specific agonist and antagonist actions. Steroids. 2002 Jan; 67(1):15-24. PMID: 11728517.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
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