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Institute for Clinical and Translational Research

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DARRYL L. HADSELL

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
DivisionPediatrics-Nutrition
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    F32HD007618     (HADSELL, DARRYL L)Feb 21, 1993
    NIH/NICHD
    TARGETING OF IGF-I EXPRESSION TO THE MAMMARY GLAND
    Role: Principal Investigator
    R01DK052197     (HADSELL, DARRYL L)Jan 24, 1997 - Feb 28, 2008
    NIH/NIDDK
    IGF-1 Receptor Signaling in Mammary Gland Development
    Role: Principal Investigator
    R21HD059746     (HADSELL, DARRYL L)Apr 10, 2009 - Feb 28, 2012
    NIH/NICHD
    QTL and QTL Genes Underlying Lactation Performance
    Role: Principal Investigator
    R21HD056439     (HADSELL, DARRYL L)Mar 3, 2010 - Feb 28, 2013
    NIH/NICHD
    Maternal obesity and mammary cell mitochondrial function during lactation
    Role: Principal Investigator
    R21HD094238     (HADSELL, DARRYL L)Jul 1, 2018 - Jun 30, 2020
    NIH/NICHD
    The Microbiome in Mammary Development, and Lacatation
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hadsell DL, Hadsell LA, Rijnkels M, Carcamo-Bahena Y, Wei J, Williamson P, Grusak MA. In silico mapping of quantitative trait loci (QTL) regulating the milk ionome in mice identifies a milk iron locus on chromosome 1. Mamm Genome. 2018 10; 29(9-10):632-655. PMID: 30073618.
      View in: PubMed
    2. Jerry DJ, Shull JD, Hadsell DL, Rijnkels M, Dunphy KA, Schneider SS, Vandenberg LN, Majhi PD, Byrne C, Trentham-Dietz A. Genetic variation in sensitivity to estrogens and breast cancer risk. Mamm Genome. 2018 02; 29(1-2):24-37. PMID: 29487996.
      View in: PubMed
    3. Hadsell DL. Diet-Induced Inflammation and Mammary Ductal Development: Alternative Activation of Estrogen-Dependent Stromal-Epithelial Signaling. Endocrinology. 2017 10 01; 158(10):3088-3089. PMID: 28977613.
      View in: PubMed
    4. Pham K, Dong J, Jiang X, Qu Y, Yu H, Yang Y, Olea W, Marini JC, Chan L, Wang J, Wehrens XH, Cui X, Li Y, Hadsell DL, Cheng N. Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation. Am J Physiol Endocrinol Metab. 2017 03 01; 312(3):E136-E149. PMID: 27894063.
      View in: PubMed
    5. Guthrie G, Kulkarni M, Vlaardingerbroek H, Stoll B, Ng K, Martin C, Belmont J, Hadsell D, Heird W, Newgard CB, Olutoye O, van Goudoever J, Lauridsen C, He X, Schuchman EH, Burrin D. Multi-omic profiles of hepatic metabolism in TPN-fed preterm pigs administered new generation lipid emulsions. J Lipid Res. 2016 09; 57(9):1696-711. PMID: 27474222.
      View in: PubMed
    6. Nichols BL, Diaz-Sotomayor M, Avery SE, Chacko SK, Hadsell DL, Baker SS, Hamaker BR, Yan LK, Lin HM, Quezada-Calvillo R. Milk glucosidase activity enables suckled pup starch digestion. Mol Cell Pediatr. 2016 Dec; 3(1):4. PMID: 26830109.
      View in: PubMed
    7. Alex AP, Collier JL, Hadsell DL, Collier RJ. Milk yield differences between 1× and 4× milking are associated with changes in mammary mitochondrial number and milk protein gene expression, but not mammary cell apoptosis or SOCS gene expression. J Dairy Sci. 2015 Jul; 98(7):4439-48. PMID: 25981061.
      View in: PubMed
    8. Hadsell DL, Hadsell LA, Olea W, Rijnkels M, Creighton CJ, Smyth I, Short KM, Cox LL, Cox TC. In-silico QTL mapping of postpubertal mammary ductal development in the mouse uncovers potential human breast cancer risk loci. Mamm Genome. 2015 Feb; 26(1-2):57-79. PMID: 25552398.
      View in: PubMed
    9. Hadsell DL, Wei J, Olea W, Hadsell LA, Renwick A, Thomson PC, Shariflou M, Williamson P. In silico QTL mapping of maternal nurturing ability with the mouse diversity panel. Physiol Genomics. 2012 Aug 17; 44(16):787-98. PMID: 22759921.
      View in: PubMed
    10. Neville MC, Anderson SM, McManaman JL, Badger TM, Bunik M, Contractor N, Crume T, Dabelea D, Donovan SM, Forman N, Frank DN, Friedman JE, German JB, Goldman A, Hadsell D, Hambidge M, Hinde K, Horseman ND, Hovey RC, Janoff E, Krebs NF, Lebrilla CB, Lemay DG, MacLean PS, Meier P, Morrow AL, Neu J, Nommsen-Rivers LA, Raiten DJ, Rijnkels M, Seewaldt V, Shur BD, VanHouten J, Williamson P. Lactation and neonatal nutrition: defining and refining the critical questions. J Mammary Gland Biol Neoplasia. 2012 Jun; 17(2):167-88. PMID: 22752723.
      View in: PubMed
    11. Mohammad MA, Hadsell DL, Haymond MW. Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans. Am J Physiol Endocrinol Metab. 2012 Aug 01; 303(3):E365-76. PMID: 22649065.
      View in: PubMed
    12. Hadsell DL. Lactation Biology Symposium: circadian clocks and photoperiod in mammary gland development and lactation. J Anim Sci. 2012 Mar; 90(3):742-3. PMID: 22345105.
      View in: PubMed
    13. Maningat PD, Sen P, Rijnkels M, Hadsell DL, Bray MS, Haymond MW. Short-term administration of rhGH increases markers of cellular proliferation but not milk protein gene expression in normal lactating women. Physiol Genomics. 2011 Apr 27; 43(8):381-91. PMID: 21205870.
      View in: PubMed
    14. Hadsell DL, Olea W, Wei J, Fiorotto ML, Matsunami RK, Engler DA, Collier RJ. Developmental regulation of mitochondrial biogenesis and function in the mouse mammary gland during a prolonged lactation cycle. Physiol Genomics. 2011 Mar 29; 43(6):271-85. PMID: 21189371.
      View in: PubMed
    15. Stoll B, Horst DA, Cui L, Chang X, Ellis KJ, Hadsell DL, Suryawan A, Kurundkar A, Maheshwari A, Davis TA, Burrin DG. Chronic parenteral nutrition induces hepatic inflammation, steatosis, and insulin resistance in neonatal pigs. J Nutr. 2010 Dec; 140(12):2193-200. PMID: 20980637.
      View in: PubMed
    16. Hadsell DL, George J, Abraham PA, Collier RJ, Lambert BD. Technical note: assessing the functional capacity of mitochondria isolated from lactating mammary tissue: choose your chelating agent wisely. J Dairy Sci. 2009 May; 92(5):2038-45. PMID: 19389961.
      View in: PubMed
    17. Maningat PD, Sen P, Rijnkels M, Sunehag AL, Hadsell DL, Bray M, Haymond MW. Gene expression in the human mammary epithelium during lactation: the milk fat globule transcriptome. Physiol Genomics. 2009 Mar 03; 37(1):12-22. PMID: 19018045.
      View in: PubMed
    18. Hadsell DL, Parlow AF, Torres D, George J, Olea W. Enhancement of maternal lactation performance during prolonged lactation in the mouse by mouse GH and long-R3-IGF-I is linked to changes in mammary signaling and gene expression. J Endocrinol. 2008 Jul; 198(1):61-70. PMID: 18577570.
      View in: PubMed
    19. Maningat PD, Sen P, Sunehag AL, Hadsell DL, Haymond MW. Regulation of gene expression in human mammary epithelium: effect of breast pumping. J Endocrinol. 2007 Dec; 195(3):503-11. PMID: 18000312.
      View in: PubMed
    20. Kaplan-Lefko PJ, Sutherland BW, Evangelou AI, Hadsell DL, Barrios RJ, Foster BA, Demayo F, Greenberg NM. Enforced epithelial expression of IGF-1 causes hyperplastic prostate growth while negative selection is requisite for spontaneous metastogenesis. Oncogene. 2008 May 01; 27(20):2868-76. PMID: 18026134.
      View in: PubMed
    21. Hadsell DL, Olea W, Lawrence N, George J, Torres D, Kadowaki T, Lee AV. Decreased lactation capacity and altered milk composition in insulin receptor substrate null mice is associated with decreased maternal body mass and reduced insulin-dependent phosphorylation of mammary Akt. J Endocrinol. 2007 Aug; 194(2):327-36. PMID: 17641282.
      View in: PubMed
    22. Heckman BM, Chakravarty G, Vargo-Gogola T, Gonzales-Rimbau M, Hadsell DL, Lee AV, Settleman J, Rosen JM. Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development. Dev Biol. 2007 Sep 01; 309(1):137-49. PMID: 17662267.
      View in: PubMed
    23. Dearth RK, Cui X, Kim HJ, Hadsell DL, Lee AV. Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2. Cell Cycle. 2007 Mar 15; 6(6):705-13. PMID: 17374994.
      View in: PubMed
    24. Dearth RK, Cui X, Kim HJ, Kuiatse I, Lawrence NA, Zhang X, Divisova J, Britton OL, Mohsin S, Allred DC, Hadsell DL, Lee AV. Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2. Mol Cell Biol. 2006 Dec; 26(24):9302-14. PMID: 17030631.
      View in: PubMed
    25. Divisova J, Kuiatse I, Lazard Z, Weiss H, Vreeland F, Hadsell DL, Schiff R, Osborne CK, Lee AV. The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth. Breast Cancer Res Treat. 2006 Aug; 98(3):315-27. PMID: 16541323.
      View in: PubMed
    26. Hadsell DL, Torres D, George J, Capuco AV, Ellis SE, Fiorotto ML. Changes in secretory cell turnover, and mitochondrial oxidative damage in the mouse mammary gland during a single prolonged lactation cycle suggest the possibility of accelerated cellular aging. Exp Gerontol. 2006 Mar; 41(3):271-81. PMID: 16442254.
      View in: PubMed
    27. Keasler VV, Lerat H, Madden CR, Finegold MJ, McGarvey MJ, Mohammed EM, Forbes SJ, Lemon SM, Hadsell DL, Grona SJ, Hollinger FB, Slagle BL. Increased liver pathology in hepatitis C virus transgenic mice expressing the hepatitis B virus X protein. Virology. 2006 Apr 10; 347(2):466-75. PMID: 16427673.
      View in: PubMed
    28. Guan X, Karpen HE, Stephens J, Bukowski JT, Niu S, Zhang G, Stoll B, Finegold MJ, Holst JJ, Hadsell D, Hadsell DL, Nichols BL, Burrin DG. GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow. Gastroenterology. 2006 Jan; 130(1):150-64. PMID: 16401478.
      View in: PubMed
    29. Hadsell DL, Torres DT, Lawrence NA, George J, Parlow AF, Lee AV, Fiorotto ML. Overexpression of des(1-3) insulin-like growth factor 1 in the mammary glands of transgenic mice delays the loss of milk production with prolonged lactation. Biol Reprod. 2005 Dec; 73(6):1116-25. PMID: 16079306.
      View in: PubMed
    30. Carboni JM, Lee AV, Hadsell DL, Rowley BR, Lee FY, Bol DK, Camuso AE, Gottardis M, Greer AF, Ho CP, Hurlburt W, Li A, Saulnier M, Velaparthi U, Wang C, Wen ML, Westhouse RA, Wittman M, Zimmermann K, Rupnow BA, Wong TW. Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor. Cancer Res. 2005 May 01; 65(9):3781-7. PMID: 15867374.
      View in: PubMed
    31. Hadsell DL. Genetic manipulation of mammary gland development and lactation. Adv Exp Med Biol. 2004; 554:229-51. PMID: 15384580.
      View in: PubMed
    32. Lee AV, Taylor ST, Greenall J, Mills JD, Tonge DW, Zhang P, George J, Fiorotto ML, Hadsell DL. Rapid induction of IGF-IR signaling in normal and tumor tissue following intravenous injection of IGF-I in mice. Horm Metab Res. 2003 Nov-Dec; 35(11-12):651-5. PMID: 14710342.
      View in: PubMed
    33. Oesterreich S, Deng W, Jiang S, Cui X, Ivanova M, Schiff R, Kang K, Hadsell DL, Behrens J, Lee AV. Estrogen-mediated down-regulation of E-cadherin in breast cancer cells. Cancer Res. 2003 Sep 01; 63(17):5203-8. PMID: 14500345.
      View in: PubMed
    34. Hadsell DL, Bonnette S, George J, Torres D, Klimentidis Y, Klementidis Y, Gao S, Haney PM, Summy-Long J, Soloff MS, Parlow AF, Sirito M, Sawadogo M. Diminished milk synthesis in upstream stimulatory factor 2 null mice is associated with decreased circulating oxytocin and decreased mammary gland expression of eukaryotic initiation factors 4E and 4G. Mol Endocrinol. 2003 Nov; 17(11):2251-67. PMID: 12907752.
      View in: PubMed
    35. Lee AV, Zhang P, Ivanova M, Bonnette S, Oesterreich S, Rosen JM, Grimm S, Hovey RC, Vonderhaar BK, Kahn CR, Torres D, George J, Mohsin S, Allred DC, Hadsell DL. Developmental and hormonal signals dramatically alter the localization and abundance of insulin receptor substrate proteins in the mammary gland. Endocrinology. 2003 Jun; 144(6):2683-94. PMID: 12746333.
      View in: PubMed
    36. Hadsell DL. The insulin-like growth factor system in normal mammary gland function. Breast Dis. 2003; 17:3-14. PMID: 15687673.
      View in: PubMed
    37. Lee AV, Schiff R, Cui X, Sachdev D, Yee D, Gilmore AP, Streuli CH, Oesterreich S, Hadsell DL. New mechanisms of signal transduction inhibitor action: receptor tyrosine kinase down-regulation and blockade of signal transactivation. Clin Cancer Res. 2003 Jan; 9(1 Pt 2):516S-23S. PMID: 12538509.
      View in: PubMed
    38. Hovey RC, Harris J, Hadsell DL, Lee AV, Ormandy CJ, Vonderhaar BK. Local insulin-like growth factor-II mediates prolactin-induced mammary gland development. Mol Endocrinol. 2003 Mar; 17(3):460-71. PMID: 12554791.
      View in: PubMed
    39. Hadsell DL, Bonnette SG, Lee AV. Genetic manipulation of the IGF-I axis to regulate mammary gland development and function. J Dairy Sci. 2002 Feb; 85(2):365-77. PMID: 11913696.
      View in: PubMed
    40. Bonnette SG, Hadsell DL. Targeted disruption of the IGF-I receptor gene decreases cellular proliferation in mammary terminal end buds. Endocrinology. 2001 Nov; 142(11):4937-45. PMID: 11606462.
      View in: PubMed
    41. Hadsell DL, Alexeenko T, Klimentidis Y, Klemintidis Y, Torres D, Lee AV. Inability of overexpressed des(1-3)human insulin-like growth factor I (IGF-I) to inhibit forced mammary gland involution is associated with decreased expression of IGF signaling molecules. Endocrinology. 2001 Apr; 142(4):1479-88. PMID: 11250928.
      View in: PubMed
    42. Hadsell DL, Abdel-Fattah G. Regulation of cell apoptosis by insulin-like growth factor I. Adv Exp Med Biol. 2001; 501:79-85. PMID: 11787734.
      View in: PubMed
    43. Hadsell DL, Murphy KL, Bonnette SG, Reece N, Laucirica R, Rosen JM. Cooperative interaction between mutant p53 and des(1-3)IGF-I accelerates mammary tumorigenesis. Oncogene. 2000 Feb 17; 19(7):889-98. PMID: 10702797.
      View in: PubMed
    44. Hadsell DL, Bonnette SG. IGF and insulin action in the mammary gland: lessons from transgenic and knockout models. J Mammary Gland Biol Neoplasia. 2000 Jan; 5(1):19-30. PMID: 10791765.
      View in: PubMed
    45. Burrin DG, Fiorotto ML, Hadsell DL. Transgenic hypersecretion of des(1-3) human insulin-like growth factor I in mouse milk has limited effects on the gastrointestinal tract in suckling pups. J Nutr. 1999 Jan; 129(1):51-6. PMID: 9915875.
      View in: PubMed
    46. Hadsell DL, Greenberg NM, Fligger JM, Baumrucker CR, Rosen JM. Targeted expression of des(1-3) human insulin-like growth factor I in transgenic mice influences mammary gland development and IGF-binding protein expression. Endocrinology. 1996 Jan; 137(1):321-30. PMID: 8536631.
      View in: PubMed
    47. Hadsell DL, Gibson CA, Baumrucker CR. Insulin-like growth factor (IGF) binding to a murine mammary epithelial cell line. J Cell Physiol. 1994 Dec; 161(3):435-40. PMID: 7525614.
      View in: PubMed
    48. Baumrucker CR, Hadsell DL, Blum JW. Effects of dietary insulin-like growth factor I on growth and insulin-like growth factor receptors in neonatal calf intestine. J Anim Sci. 1994 Feb; 72(2):428-33. PMID: 8157526.
      View in: PubMed
    49. Hadsell DL, Baumrucker CR, Kensinger RS. Effects of elevated blood insulin-like growth factor-I (IGF-I) concentration upon IGF-I in bovine mammary secretions during the colostrum phase. J Endocrinol. 1993 May; 137(2):223-30. PMID: 8326250.
      View in: PubMed
    50. Vega JR, Gibson CA, Skaar TC, Hadsell DL, Baumrucker CR. Insulin-like growth factor (IGF)-I and -II and IGF binding proteins in serum and mammary secretions during the dry period and early lactation in dairy cows. J Anim Sci. 1991 Jun; 69(6):2538-47. PMID: 1715849.
      View in: PubMed
    51. Schober DA, Simmen FA, Hadsell DL, Baumrucker CR. Perinatal expression of type I IGF receptors in porcine small intestine. Endocrinology. 1990 Feb; 126(2):1125-32. PMID: 2153520.
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    52. Hadsell DL, Campbell PG, Baumrucker CR. Characterization of the change in type I and II insulin-like growth factor receptors of bovine mammary tissue during the pre- and postpartum periods. Endocrinology. 1990 Jan; 126(1):637-43. PMID: 2152876.
      View in: PubMed
    53. Hadsell DL, Sommerfeldt JL. Chickpeas as a protein and energy supplement for high producing dairy cows. J Dairy Sci. 1988 Mar; 71(3):762-72. PMID: 3372819.
      View in: PubMed
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