DARRYL HADSELL

Title	Associate Professor
Institution	Baylor College of Medicine
Department	Department of Pediatrics
Address	1100 BATES Houston, TX 77030
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Other Positions


Title	Assistant Professor
Institution	Baylor College of Medicine
Department	Department of Molecular & Cellular Biology
Division	Molecular & Cellular Biology

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Verify Publications

Research

research activities and funding

F32HD007618 (HADSELL, DARRYL L)Feb 21, 1993 NIH/NICHD TARGETING OF IGF-I EXPRESSION TO THE MAMMARY GLAND Role: Principal Investigator

R01DK052197 (HADSELL, DARRYL L)Jan 24, 1997 - Feb 28, 2008 NIH/NIDDK IGF-1 Receptor Signaling in Mammary Gland Development Role: Principal Investigator

R21HD059746 (HADSELL, DARRYL L)Apr 10, 2009 - Feb 28, 2012 NIH/NICHD QTL and QTL Genes Underlying Lactation Performance Role: Principal Investigator

R21HD056439 (HADSELL, DARRYL L)Mar 3, 2010 - Feb 28, 2013 NIH/NICHD Maternal obesity and mammary cell mitochondrial function during lactation Role: Principal Investigator

R21HD094238 (HADSELL, DARRYL L)Jul 1, 2018 - Jun 30, 2020 NIH/NICHD The Microbiome in Mammary Development, and Lacatation Role: Principal Investigator

Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Huang J, Dai B, Qu H, Zhong Y, Ma Y, Luo J, Hadsell D, Shi H. Epidermal Growth Factor Stimulates Fatty Acid Synthesis Mainly via PLC-?1/Akt Signaling Pathway in Dairy Goat Mammary Epithelial Cells. Animals (Basel). 2020 May 28; 10(6). PMID: 32481546.

Citations:
Hadsell DL, Hadsell LA, Rijnkels M, Carcamo-Bahena Y, Wei J, Williamson P, Grusak MA. In silico mapping of quantitative trait loci (QTL) regulating the milk ionome in mice identifies a milk iron locus on chromosome 1. Mamm Genome. 2018 10; 29(9-10):632-655. PMID: 30073618.

Citations: Fields:
Gen Genetics
Translation:Animals Cells
Jerry DJ, Shull JD, Hadsell DL, Rijnkels M, Dunphy KA, Schneider SS, Vandenberg LN, Majhi PD, Byrne C, Trentham-Dietz A. Genetic variation in sensitivity to estrogens and breast cancer risk. Mamm Genome. 2018 02; 29(1-2):24-37. PMID: 29487996.

Citations: 5 Fields:
Gen Genetics
Translation:Humans Animals
Hadsell DL. Diet-Induced Inflammation and Mammary Ductal Development: Alternative Activation of Estrogen-Dependent Stromal-Epithelial Signaling. Endocrinology. 2017 10 01; 158(10):3088-3089. PMID: 28977613.

Citations: Fields:
End Endocrinology
Translation:Humans Animals Cells
Pham K, Dong J, Jiang X, Qu Y, Yu H, Yang Y, Olea W, Marini JC, Chan L, Wang J, Wehrens XH, Cui X, Li Y, Hadsell DL, Cheng N. Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation. Am J Physiol Endocrinol Metab. 2017 03 01; 312(3):E136-E149. PMID: 27894063.

Citations: 3 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Animals Cells
Guthrie G, Kulkarni M, Vlaardingerbroek H, Stoll B, Ng K, Martin C, Belmont J, Hadsell D, Heird W, Newgard CB, Olutoye O, van Goudoever J, Lauridsen C, He X, Schuchman EH, Burrin D. Multi-omic profiles of hepatic metabolism in TPN-fed preterm pigs administered new generation lipid emulsions. J Lipid Res. 2016 09; 57(9):1696-711. PMID: 27474222.

Citations: 5 Fields:
Bio Biochemistry
Translation:Animals
Hadsell DL, Hadsell LA, Olea W, Rijnkels M, Creighton CJ, Smyth I, Short KM, Cox LL, Cox TC. In-silico QTL mapping of postpubertal mammary ductal development in the mouse uncovers potential human breast cancer risk loci. Mamm Genome. 2015 Feb; 26(1-2):57-79. PMID: 25552398.

Citations: 5 Fields:
Gen Genetics
Translation:Humans Animals
Hadsell DL, Wei J, Olea W, Hadsell LA, Renwick A, Thomson PC, Shariflou M, Williamson P. In silico QTL mapping of maternal nurturing ability with the mouse diversity panel. Physiol Genomics. 2012 Aug 17; 44(16):787-98. PMID: 22759921.

Citations: 4 Fields:
Mol Molecular Biology
Translation:Animals
Neville MC, Anderson SM, McManaman JL, Badger TM, Bunik M, Contractor N, Crume T, Dabelea D, Donovan SM, Forman N, Frank DN, Friedman JE, German JB, Goldman A, Hadsell D, Hambidge M, Hinde K, Horseman ND, Hovey RC, Janoff E, Krebs NF, Lebrilla CB, Lemay DG, MacLean PS, Meier P, Morrow AL, Neu J, Nommsen-Rivers LA, Raiten DJ, Rijnkels M, Seewaldt V, Shur BD, VanHouten J, Williamson P. Lactation and neonatal nutrition: defining and refining the critical questions. J Mammary Gland Biol Neoplasia. 2012 Jun; 17(2):167-88. PMID: 22752723.

Citations: 26 Fields:
Neo Neoplasms
Translation:Humans Animals
Mohammad MA, Hadsell DL, Haymond MW. Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans. Am J Physiol Endocrinol Metab. 2012 Aug 01; 303(3):E365-76. PMID: 22649065.

Citations: 14 Fields:
End Endocrinology Met Metabolism Phy Physiology
Translation:Humans
Hadsell DL. Lactation Biology Symposium: circadian clocks and photoperiod in mammary gland development and lactation. J Anim Sci. 2012 Mar; 90(3):742-3. PMID: 22345105.

Citations: Fields:
Vet Veterinary Medicine
Translation:Animals
Maningat PD, Sen P, Rijnkels M, Hadsell DL, Bray MS, Haymond MW. Short-term administration of rhGH increases markers of cellular proliferation but not milk protein gene expression in normal lactating women. Physiol Genomics. 2011 Apr 27; 43(8):381-91. PMID: 21205870.

Citations: 8 Fields:
Mol Molecular Biology
Translation:Humans
Hadsell DL, Olea W, Wei J, Fiorotto ML, Matsunami RK, Engler DA, Collier RJ. Developmental regulation of mitochondrial biogenesis and function in the mouse mammary gland during a prolonged lactation cycle. Physiol Genomics. 2011 Mar 29; 43(6):271-85. PMID: 21189371.

Citations: 2 Fields:
Mol Molecular Biology
Translation:Animals Cells
Stoll B, Horst DA, Cui L, Chang X, Ellis KJ, Hadsell DL, Suryawan A, Kurundkar A, Maheshwari A, Davis TA, Burrin DG. Chronic parenteral nutrition induces hepatic inflammation, steatosis, and insulin resistance in neonatal pigs. J Nutr. 2010 Dec; 140(12):2193-200. PMID: 20980637.

Citations: 30 Fields:
Nut Nutritional Sciences
Translation:Animals
Maningat PD, Sen P, Rijnkels M, Sunehag AL, Hadsell DL, Bray M, Haymond MW. Gene expression in the human mammary epithelium during lactation: the milk fat globule transcriptome. Physiol Genomics. 2009 Mar 03; 37(1):12-22. PMID: 19018045.

Citations: 50 Fields:
Mol Molecular Biology
Translation:Humans Animals
Hadsell DL, Parlow AF, Torres D, George J, Olea W. Enhancement of maternal lactation performance during prolonged lactation in the mouse by mouse GH and long-R3-IGF-I is linked to changes in mammary signaling and gene expression. J Endocrinol. 2008 Jul; 198(1):61-70. PMID: 18577570.

Citations: 3 Fields:
End Endocrinology
Translation:Animals Cells
Maningat PD, Sen P, Sunehag AL, Hadsell DL, Haymond MW. Regulation of gene expression in human mammary epithelium: effect of breast pumping. J Endocrinol. 2007 Dec; 195(3):503-11. PMID: 18000312.

Citations: 13 Fields:
End Endocrinology
Translation:Humans Animals Cells
Hadsell DL, Olea W, Lawrence N, George J, Torres D, Kadowaki T, Lee AV. Decreased lactation capacity and altered milk composition in insulin receptor substrate null mice is associated with decreased maternal body mass and reduced insulin-dependent phosphorylation of mammary Akt. J Endocrinol. 2007 Aug; 194(2):327-36. PMID: 17641282.

Citations: 11 Fields:
End Endocrinology
Translation:Animals Cells
Heckman BM, Chakravarty G, Vargo-Gogola T, Gonzales-Rimbau M, Hadsell DL, Lee AV, Settleman J, Rosen JM. Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development. Dev Biol. 2007 Sep 01; 309(1):137-49. PMID: 17662267.

Citations: 21 Fields:
Bio Biology Emb Embryology
Translation:Animals Cells
Dearth RK, Cui X, Kim HJ, Hadsell DL, Lee AV. Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2. . 2007 Mar 15; 6(6):705-13. PMID: 17374994.

Citations:
Dearth RK, Cui X, Kim HJ, Kuiatse I, Lawrence NA, Zhang X, Divisova J, Britton OL, Mohsin S, Allred DC, Hadsell DL, Lee AV. Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2. Mol Cell Biol. 2006 Dec; 26(24):9302-14. PMID: 17030631.

Citations: 67 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Animals Cells
Divisova J, Kuiatse I, Lazard Z, Weiss H, Vreeland F, Hadsell DL, Schiff R, Osborne CK, Lee AV. The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth. Breast Cancer Res Treat. 2006 Aug; 98(3):315-27. PMID: 16541323.

Citations: 30 Fields:
Neo Neoplasms
Translation:Humans Animals Cells
Hadsell DL, Torres D, George J, Capuco AV, Ellis SE, Fiorotto ML. Changes in secretory cell turnover, and mitochondrial oxidative damage in the mouse mammary gland during a single prolonged lactation cycle suggest the possibility of accelerated cellular aging. Exp Gerontol. 2006 Mar; 41(3):271-81. PMID: 16442254.

Citations: 5 Fields:
Ger Geriatrics
Translation:Animals Cells
Keasler VV, Lerat H, Madden CR, Finegold MJ, McGarvey MJ, Mohammed EM, Forbes SJ, Lemon SM, Hadsell DL, Grona SJ, Hollinger FB, Slagle BL. Increased liver pathology in hepatitis C virus transgenic mice expressing the hepatitis B virus X protein. Virology. 2006 Apr 10; 347(2):466-75. PMID: 16427673.

Citations: 16 Fields:
Vir Virology
Translation:Animals Cells
Guan X, Karpen HE, Stephens J, Bukowski JT, Niu S, Zhang G, Stoll B, Finegold MJ, Holst JJ, Hadsell D, Hadsell DL, Nichols BL, Burrin DG. GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow. Gastroenterology. 2006 Jan; 130(1):150-64. PMID: 16401478.

Citations: 62 Fields:
Gas Gastroenterology
Translation:Humans Animals Cells
Hadsell DL, Torres DT, Lawrence NA, George J, Parlow AF, Lee AV, Fiorotto ML. Overexpression of des(1-3) insulin-like growth factor 1 in the mammary glands of transgenic mice delays the loss of milk production with prolonged lactation. Biol Reprod. 2005 Dec; 73(6):1116-25. PMID: 16079306.

Citations: 10 Fields:
Rep Reproductive Medicine
Translation:Animals Cells
Carboni JM, Lee AV, Hadsell DL, Rowley BR, Lee FY, Bol DK, Camuso AE, Gottardis M, Greer AF, Ho CP, Hurlburt W, Li A, Saulnier M, Velaparthi U, Wang C, Wen ML, Westhouse RA, Wittman M, Zimmermann K, Rupnow BA, Wong TW. Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor. Cancer Res. 2005 May 01; 65(9):3781-7. PMID: 15867374.

Citations: 66 Fields:
Neo Neoplasms
Translation:Humans Animals
Hadsell DL. Genetic manipulation of mammary gland development and lactation. Adv Exp Med Biol. 2004; 554:229-51. PMID: 15384580.

Citations: 2 Fields:
Bio Biology Med Medicine (General)
Translation:Humans Animals Cells
Oesterreich S, Deng W, Jiang S, Cui X, Ivanova M, Schiff R, Kang K, Hadsell DL, Behrens J, Lee AV. Estrogen-mediated down-regulation of E-cadherin in breast cancer cells. Cancer Res. 2003 Sep 01; 63(17):5203-8. PMID: 14500345.

Citations: 35 Fields:
Neo Neoplasms
Translation:Humans Cells
Hadsell DL, Bonnette S, George J, Torres D, Klimentidis Y, Klementidis Y, Gao S, Haney PM, Summy-Long J, Soloff MS, Parlow AF, Sirito M, Sawadogo M. Diminished milk synthesis in upstream stimulatory factor 2 null mice is associated with decreased circulating oxytocin and decreased mammary gland expression of eukaryotic initiation factors 4E and 4G. Mol Endocrinol. 2003 Nov; 17(11):2251-67. PMID: 12907752.

Citations: 9 Fields:
End Endocrinology Mol Molecular Biology
Translation:Animals
Hadsell DL. The insulin-like growth factor system in normal mammary gland function. Breast Dis. 2003; 17:3-14. PMID: 15687673.

Citations: 6 Fields:
Gyn Gynecology
Lee AV, Schiff R, Cui X, Sachdev D, Yee D, Gilmore AP, Streuli CH, Oesterreich S, Hadsell DL. New mechanisms of signal transduction inhibitor action: receptor tyrosine kinase down-regulation and blockade of signal transactivation. Clin Cancer Res. 2003 Jan; 9(1 Pt 2):516S-23S. PMID: 12538509.

Citations: 2 Fields:
Neo Neoplasms
Translation:Humans Cells
Hovey RC, Harris J, Hadsell DL, Lee AV, Ormandy CJ, Vonderhaar BK. Local insulin-like growth factor-II mediates prolactin-induced mammary gland development. Mol Endocrinol. 2003 Mar; 17(3):460-71. PMID: 12554791.

Citations: 26 Fields:
End Endocrinology Mol Molecular Biology
Translation:Animals