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DANIEL MEDINA

TitleProfessor Emeritus
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology
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    R01CA011944     (MEDINA, DANIEL NONE)Sep 30, 1977 - Mar 31, 1997
    NIH/NCI
    BIOLOGY OF MOUSE MAMMARY PRENEOPLASIAS
    Role: Principal Investigator

    R01CA039017     (MEDINA, DANIEL NONE)Jan 1, 1985 - Dec 31, 1987
    NIH/NCI
    CELL LINEAGES IN NORMAL AND PRENEOPLASTIC MAMMARY GROWTH
    Role: Principal Investigator

    R01CA047112     (MEDINA, DANIEL NONE)Apr 1, 1988 - Nov 30, 1999
    NIH/NCI
    EARLY EVENTS IN MULTIPLE-STAGE MAMMARY TUMORIGENESIS
    Role: Principal Investigator

    R13CA055154     (MEDINA, DANIEL NONE)Aug 1, 1991 - Jul 31, 1992
    NIH/NCI
    GORDON RESEARCH CONFERENCE--MAMMARY GLAND BIOLOGY
    Role: Principal Investigator

    R01CA063137     (MEDINA, DANIEL NONE)May 1, 1994 - Apr 30, 1997
    NIH/NCI
    IMMORTALIZATION AND MAMMORY TUMORIGENESIS
    Role: Principal Investigator

    P01CA064255     (MEDINA, DANIEL NONE)Aug 1, 1995 - Nov 30, 2001
    NIH/NCI
    Mechanisms of the Hormonal Prevention of Breast Cancer
    Role: Principal Investigator

    U01CA084243     (ROSEN, JEFFREY)Sep 30, 1999 - Mar 31, 2010
    NIH/NCI
    Mouse Models of Human Breast Cancer
    Role: Co-Principal Investigator

    R01CA084320     (MEDINA, DANIEL NONE)Jan 1, 2000 - Dec 31, 2005
    NIH/NCI
    P53 AND MOUSE MAMMARY TUMORIGENESIS
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Palaniappan M, Edwards D, Creighton CJ, Medina D, Conneely OM. Reprogramming of the estrogen responsive transcriptome contributes to tamoxifen-dependent protection against tumorigenesis in the p53 null mammary epithelial cells. PLoS One. 2018; 13(3):e0194913. PMID: 29590203.
      View in: PubMed
    2. Bansal N, Bartucci M, Yusuff S, Davis S, Flaherty K, Huselid E, Patrizii M, Jones D, Cao L, Sydorenko N, Moon YC, Zhong H, Medina DJ, Kerrigan J, Stein MN, Kim IY, Davis TW, DiPaola RS, Bertino JR, Sabaawy HE. BMI-1 Targeting Interferes with Patient-Derived Tumor-Initiating Cell Survival and Tumor Growth in Prostate Cancer. Clin Cancer Res. 2016 Dec 15; 22(24):6176-6191. PMID: 27307599.
      View in: PubMed
    3. Kittrell F, Valdez K, Elsarraj H, Hong Y, Medina D, Behbod F. Mouse Mammary Intraductal (MIND) Method for Transplantation of Patient Derived Primary DCIS Cells and Cell Lines. Bio Protoc. 2016 Mar 05; 6(5). PMID: 27446983.
      View in: PubMed
    4. Zheng ZY, Tian L, Bu W, Fan C, Gao X, Wang H, Liao YH, Li Y, Lewis MT, Edwards D, Zwaka TP, Hilsenbeck SG, Medina D, Perou CM, Creighton CJ, Zhang XH, Chang EC. Wild-Type N-Ras, Overexpressed in Basal-like Breast Cancer, Promotes Tumor Formation by Inducing IL-8 Secretion via JAK2 Activation. Cell Rep. 2015 Jul 21; 12(3):511-24. PMID: 26166574.
      View in: PubMed
    5. Suo J, Medina D, Herrera S, Zheng ZY, Jin L, Chamness GC, Contreras A, Gutierrez C, Hilsenbeck S, Umar A, Foekens JA, Hanash S, Schiff R, Zhang XH, Chang EC. Int6 reduction activates stromal fibroblasts to enhance transforming activity in breast epithelial cells. Cell Biosci. 2015; 5:10. PMID: 25774287.
      View in: PubMed
    6. Dolfi SC, J├Ąger AV, Medina DJ, Haffty BG, Yang JM, Hirshfield KM. Fulvestrant treatment alters MDM2 protein turnover and sensitivity of human breast carcinoma cells to chemotherapeutic drugs. Cancer Lett. 2014 Aug 01; 350(1-2):52-60. PMID: 24747123.
      View in: PubMed
    7. Medina DJ, Abass-Shereef J, Walton K, Goodell L, Aviv H, Strair RK, Budak-Alpdogan T. Cobblestone-area forming cells derived from patients with mantle cell lymphoma are enriched for CD133+ tumor-initiating cells. PLoS One. 2014; 9(4):e91042. PMID: 24722054.
      View in: PubMed
    8. Mukherjee M, Ge G, Zhang N, Edwards DG, Sumazin P, Sharan SK, Rao PH, Medina D, Pati D. MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ERa)-positive mammary adenocarcinomas. Oncogene. 2014 Nov 27; 33(48):5511-5522. PMID: 24276237.
      View in: PubMed
    9. Rehman SK, Li SH, Wyszomierski SL, Wang Q, Li P, Sahin O, Xiao Y, Zhang S, Xiong Y, Yang J, Wang H, Guo H, Zhang JD, Medina D, Muller WJ, Yu D. 14-3-3? orchestrates mammary tumor onset and progression via miR-221-mediated cell proliferation. Cancer Res. 2014 Jan 01; 74(1):363-373. PMID: 24197133.
      View in: PubMed
    10. Mehta MS, Dolfi SC, Bronfenbrener R, Bilal E, Chen C, Moore D, Lin Y, Rahim H, Aisner S, Kersellius RD, Teh J, Chen S, Toppmeyer DL, Medina DJ, Ganesan S, Vazquez A, Hirshfield KM. Metabotropic glutamate receptor 1 expression and its polymorphic variants associate with breast cancer phenotypes. PLoS One. 2013; 8(7):e69851. PMID: 23922822.
      View in: PubMed
    11. Machado HL, Kittrell FS, Edwards D, White AN, Atkinson RL, Rosen JM, Medina D, Lewis MT. Separation by cell size enriches for mammary stem cell repopulation activity. Stem Cells Transl Med. 2013 Mar; 2(3):199-203. PMID: 23408103.
      View in: PubMed
    12. Mazumdar A, Medina D, Kittrell FS, Zhang Y, Hill JL, Edwards DE, Bissonnette RP, Brown PH. The combination of tamoxifen and the rexinoid LG100268 prevents ER-positive and ER-negative mammary tumors in p53-null mammary gland mice. Cancer Prev Res (Phila). 2012 Oct; 5(10):1195-202. PMID: 22926341.
      View in: PubMed
    13. Medina D, Edwards DG, Kittrell F, Lee S, Allred DC. Intra-mammary ductal transplantation: a tool to study premalignant progression. J Mammary Gland Biol Neoplasia. 2012 Jun; 17(2):131-3. PMID: 22688217.
      View in: PubMed
    14. Lewis MT, Landua JD, Adams HC, Medina D. A mystery wrapped in an enigma: Matrigel enhancement of mammary cell growth and morphogenesis. J Mammary Gland Biol Neoplasia. 2012 Jun; 17(2):99-101. PMID: 22581302.
      View in: PubMed
    15. Herschkowitz JI, Zhao W, Zhang M, Usary J, Murrow G, Edwards D, Knezevic J, Greene SB, Darr D, Troester MA, Hilsenbeck SG, Medina D, Perou CM, Rosen JM. Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):2778-83. PMID: 21633010.
      View in: PubMed
    16. Kittrell FS, Carletti MZ, Kerbawy S, Heestand J, Xian W, Zhang M, Lamarca HL, Sonnenberg A, Rosen JM, Medina D, Behbod F. Prospective isolation and characterization of committed and multipotent progenitors from immortalized mouse mammary epithelial cells with morphogenic potential. Breast Cancer Res. 2011 Apr 05; 13(2):R41. PMID: 21466693.
      View in: PubMed
    17. Medina D. Of mice and women: A short history of mouse mammary cancer research with an emphasis on the paradigms inspired by the transplantation method. Cold Spring Harb Perspect Biol. 2010 Oct; 2(10):a004523. PMID: 20630995.
      View in: PubMed
    18. Dearth RK, Delgado DA, Hiney JK, Pathiraja T, Oesterreich S, Medina D, Dees WL, Lee AV. Parity-induced decrease in systemic growth hormone alters mammary gland signaling: a potential role in pregnancy protection from breast cancer. Cancer Prev Res (Phila). 2010 Mar; 3(3):312-21. PMID: 20145191.
      View in: PubMed
    19. Kaipparettu BA, Dobrzycka KM, Britton O, Lee AV, Herron AJ, Li Y, Lewis MT, Medina D, Oesterreich S. Scaffold Attachment Factor B1 (SAFB1) heterozygosity does not influence Wnt-1 or DMBA-induced tumorigenesis. Mol Cancer. 2009 Mar 06; 8:15. PMID: 19267898.
      View in: PubMed
    20. Medina D, Kittrell F, Hill J, Zhang Y, Hilsenbeck SG, Bissonette R, Brown PH. Prevention of tumorigenesis in p53-null mammary epithelium by rexinoid bexarotene, tyrosine kinase inhibitor gefitinib, and celecoxib. Cancer Prev Res (Phila). 2009 Feb; 2(2):168-74. PMID: 19174577.
      View in: PubMed
    21. Zhang N, Ge G, Meyer R, Sethi S, Basu D, Pradhan S, Zhao YJ, Li XN, Cai WW, El-Naggar AK, Baladandayuthapani V, Kittrell FS, Rao PH, Medina D, Pati D. Overexpression of Separase induces aneuploidy and mammary tumorigenesis. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):13033-8. PMID: 18728194.
      View in: PubMed
    22. Medina D. Premalignant and malignant mammary lesions induced by MMTV and chemical carcinogens. J Mammary Gland Biol Neoplasia. 2008 Sep; 13(3):271-7. PMID: 18663563.
      View in: PubMed
    23. Zhang M, Behbod F, Atkinson RL, Landis MD, Kittrell F, Edwards D, Medina D, Tsimelzon A, Hilsenbeck S, Green JE, Michalowska AM, Rosen JM. Identification of tumor-initiating cells in a p53-null mouse model of breast cancer. Cancer Res. 2008 Jun 15; 68(12):4674-82. PMID: 18559513.
      View in: PubMed
    24. Loehberg CR, Thompson T, Kastan MB, Maclean KH, Edwards DG, Kittrell FS, Medina D, Conneely OM, O'Malley BW. Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis. Cancer Res. 2007 Dec 15; 67(24):12026-33. PMID: 18089834.
      View in: PubMed
    25. Li Z, Schem C, Shi YH, Medina D, Zhang M. Increased COX2 expression enhances tumor-induced osteoclastic lesions in breast cancer bone metastasis. Clin Exp Metastasis. 2008; 25(4):389-400. PMID: 17965942.
      View in: PubMed
    26. Gatza CE, Dumble M, Kittrell F, Edwards DG, Dearth RK, Lee AV, Xu J, Medina D, Donehower LA. Altered mammary gland development in the p53+/m mouse, a model of accelerated aging. Dev Biol. 2008 Jan 01; 313(1):130-41. PMID: 17996864.
      View in: PubMed
    27. Goepfert TM, Moreno-Smith M, Edwards DG, Pathak S, Medina D, Brinkley WR. Loss of chromosomal integrity drives rat mammary tumorigenesis. Int J Cancer. 2007 Mar 01; 120(5):985-94. PMID: 17131329.
      View in: PubMed
    28. Medina D. Chemical carcinogenesis of rat and mouse mammary glands. Breast Dis. 2007; 28:63-8. PMID: 18057544.
      View in: PubMed
    29. Lee S, Mohsin SK, Mao S, Hilsenbeck SG, Medina D, Allred DC. Hormones, receptors, and growth in hyperplastic enlarged lobular units: early potential precursors of breast cancer. Breast Cancer Res. 2006; 8(1):R6. PMID: 16417654.
      View in: PubMed
    30. Kuang SQ, Liao L, Wang S, Medina D, O'Malley BW, Xu J. Mice lacking the amplified in breast cancer 1/steroid receptor coactivator-3 are resistant to chemical carcinogen-induced mammary tumorigenesis. Cancer Res. 2005 Sep 01; 65(17):7993-8002. PMID: 16140972.
      View in: PubMed
    31. Medina D. Mammary developmental fate and breast cancer risk. Endocr Relat Cancer. 2005 Sep; 12(3):483-95. PMID: 16172188.
      View in: PubMed
    32. Medina D, Kittrell FS, Hill J, Shepard A, Thordarson G, Brown P. Tamoxifen inhibition of estrogen receptor-alpha-negative mouse mammary tumorigenesis. Cancer Res. 2005 Apr 15; 65(8):3493-6. PMID: 15833886.
      View in: PubMed
    33. Medina D, Kittrell F. Stroma is not a major target in DMBA-mediated tumorigenesis of mouse mammary preneoplasia. J Cell Sci. 2005 Jan 01; 118(Pt 1):123-7. PMID: 15585572.
      View in: PubMed
    34. Allred DC, Brown P, Medina D. The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer. Breast Cancer Res. 2004; 6(6):240-5. PMID: 15535853.
      View in: PubMed
    35. Pati D, Haddad BR, Haegele A, Thompson H, Kittrell FS, Shepard A, Montagna C, Zhang N, Ge G, Otta SK, McCarthy M, Ullrich RL, Medina D. Hormone-induced chromosomal instability in p53-null mammary epithelium. Cancer Res. 2004 Aug 15; 64(16):5608-16. PMID: 15313898.
      View in: PubMed
    36. Yi Y, Shepard A, Kittrell F, Mulac-Jericevic B, Medina D, Said TK. p19ARF determines the balance between normal cell proliferation rate and apoptosis during mammary gland development. Mol Biol Cell. 2004 May; 15(5):2302-11. PMID: 15105443.
      View in: PubMed
    37. Medina D. Stromal fibroblasts influence human mammary epithelial cell morphogenesis. Proc Natl Acad Sci U S A. 2004 Apr 06; 101(14):4723-4. PMID: 15051868.
      View in: PubMed
    38. Said TK, Medina D. Cell cycle genes in a mouse mammary hyperplasia model. J Mammary Gland Biol Neoplasia. 2004 Jan; 9(1):81-93. PMID: 15082920.
      View in: PubMed
    39. Medina D. Breast cancer: the protective effect of pregnancy. Clin Cancer Res. 2004 Jan 01; 10(1 Pt 2):380S-4S. PMID: 14734495.
      View in: PubMed
    40. Medina D, Kittrell FS. p53 function is required for hormone-mediated protection of mouse mammary tumorigenesis. Cancer Res. 2003 Oct 01; 63(19):6140-3. PMID: 14559792.
      View in: PubMed
    41. Medina D, Kittrell FS, Shepard A, Contreras A, Rosen JM, Lydon J. Hormone dependence in premalignant mammary progression. Cancer Res. 2003 Mar 01; 63(5):1067-72. PMID: 12615724.
      View in: PubMed
    42. Kong G, Chua SS, Yijun Y, Kittrell F, Moraes RC, Medina D, Said TK. Functional analysis of cyclin D2 and p27(Kip1) in cyclin D2 transgenic mouse mammary gland during development. Oncogene. 2002 Oct 17; 21(47):7214-25. PMID: 12370811.
      View in: PubMed
    43. Medina D. Biological and molecular characteristics of the premalignant mouse mammary gland. Biochim Biophys Acta. 2002 Oct 02; 1603(1):1-9. PMID: 12242106.
      View in: PubMed
    44. Goepfert TM, Adigun YE, Zhong L, Gay J, Medina D, Brinkley WR. Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis. Cancer Res. 2002 Jul 15; 62(14):4115-22. PMID: 12124350.
      View in: PubMed
    45. Sivaraman L, Gay J, Hilsenbeck SG, Shine HD, Conneely OM, Medina D, O'Malley BW. Effect of selective ablation of proliferating mammary epithelial cells on MNU induced rat mammary tumorigenesis. Breast Cancer Res Treat. 2002 May; 73(1):75-83. PMID: 12083633.
      View in: PubMed
    46. Medina D, Kittrell FS, Shepard A, Stephens LC, Jiang C, Lu J, Allred DC, McCarthy M, Ullrich RL. Biological and genetic properties of the p53 null preneoplastic mammary epithelium. FASEB J. 2002 Jun; 16(8):881-3. PMID: 11967232.
      View in: PubMed
    47. Medina D, Ullrich R, Meyn R, Wiseman R, Donehower L. Environmental carcinogens and p53 tumor-suppressor gene interactions in a transgenic mouse model for mammary carcinogenesis. Environ Mol Mutagen. 2002; 39(2-3):178-83. PMID: 11921187.
      View in: PubMed
    48. Sivaraman L, Medina D. Hormone-induced protection against breast cancer. J Mammary Gland Biol Neoplasia. 2002 Jan; 7(1):77-92. PMID: 12160088.
      View in: PubMed
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