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CLAVIA WOOTON-KEE

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Pediatrics
    DivisionPediatrics-Gastroenterology


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    F32DK089689     (WOOTON-KEE, CLAVIA RUTH)Sep 25, 2010 - Sep 24, 2012
    NIH/NIDDK
    Excessive Copper Levels Disrupt Hepatic Nuclear Receptor Function
    Role: Principal Investigator

    K01DK111716     (WOOTON-KEE, CLAVIA RUTH)Feb 17, 2017 - Jan 31, 2022
    NIH/NIDDK
    Nuclear Receptors as Novel Therapeutic Targets for Wilson?s Disease
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wooton-Kee CR, Robertson M, Zhou Y, Dong B, Sun Z, Kim KH, Liu H, Xu Y, Putluri N, Saha P, Coarfa C, Moore DD, Nuotio-Antar AM. Metabolic dysregulation in the Atp7b-/- Wilson's disease mouse model. Proc Natl Acad Sci U S A. 2020 Jan 28; 117(4):2076-2083. PMID: 31924743.
      View in: PubMed
    2. Kim KH, Choi JM, Li F, Dong B, Wooton-Kee CR, Arizpe A, Anakk S, Jung SY, Hartig SM, Moore DD. Constitutive Androstane Receptor Differentially Regulates Bile Acid Homeostasis in Mouse Models of Intrahepatic Cholestasis. Hepatol Commun. 2019 Jan; 3(1):147-159. PMID: 30620001.
      View in: PubMed
    3. Pankowicz FP, Barzi M, Kim KH, Legras X, Martins CS, Wooton-Kee CR, Lagor WR, Marini JC, Elsea SH, Bissig-Choisat B, Moore DD, Bissig KD. Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing. Gastroenterology. 2018 12; 155(6):1967-1970.e6. PMID: 30170115.
      View in: PubMed
    4. Kim KH, Choi JM, Li F, Arizpe A, Wooton-Kee CR, Anakk S, Jung SY, Finegold MJ, Moore DD. Xenobiotic Nuclear Receptor Signaling Determines Molecular Pathogenesis of Progressive Familial Intrahepatic Cholestasis. Endocrinology. 2018 06 01; 159(6):2435-2446. PMID: 29718219.
      View in: PubMed
    5. Muchenditsi A, Yang H, Hamilton JP, Koganti L, Housseau F, Aronov L, Fan H, Pierson H, Bhattacharjee A, Murphy R, Sears C, Potter J, Wooton-Kee CR, Lutsenko S. Targeted inactivation of copper transporter Atp7b in hepatocytes causes liver steatosis and obesity in mice. Am J Physiol Gastrointest Liver Physiol. 2017 Jul 01; 313(1):G39-G49. PMID: 28428350.
      View in: PubMed
    6. Wagner M, Choi S, Panzitt K, Mamrosh JL, Lee JM, Zaufel A, Xiao R, Wooton-Kee R, Ståhlman M, Newgard CB, Borén J, Moore DD. Liver receptor homolog-1 is a critical determinant of methyl-pool metabolism. Hepatology. 2016 Jan; 63(1):95-106. PMID: 26267291.
      View in: PubMed
    7. Wooton-Kee CR, Jain AK, Wagner M, Grusak MA, Finegold MJ, Lutsenko S, Moore DD. Elevated copper impairs hepatic nuclear receptor function in Wilson's disease. J Clin Invest. 2015 Sep; 125(9):3449-60. PMID: 26241054.
      View in: PubMed
    8. Athippozhy A, Huang L, Wooton-Kee CR, Zhao T, Jungsuwadee P, Stromberg AJ, Vore M. Differential gene expression in liver and small intestine from lactating rats compared to age-matched virgin controls detects increased mRNA of cholesterol biosynthetic genes. BMC Genomics. 2011 Feb 03; 12:95. PMID: 21291544.
      View in: PubMed
    9. Coy DJ, Wooton-Kee CR, Yan B, Sabeva N, Su K, Graf G, Vore M. ABCG5/ABCG8-independent biliary cholesterol excretion in lactating rats. Am J Physiol Gastrointest Liver Physiol. 2010 Jul; 299(1):G228-35. PMID: 20413720.
      View in: PubMed
    10. Wooton-Kee CR, Coy DJ, Athippozhy AT, Zhao T, Jones BR, Vore M. Mechanisms for increased expression of cholesterol 7alpha-hydroxylase (Cyp7a1) in lactating rats. Hepatology. 2010 Jan; 51(1):277-85. PMID: 19957370.
      View in: PubMed
    11. Wooton-Kee CR, Cohen DE, Vore M. Increased cholesterol 7alpha-hydroxylase expression and size of the bile acid pool in the lactating rat. Am J Physiol Gastrointest Liver Physiol. 2008 Apr; 294(4):G1009-16. PMID: 18292185.
      View in: PubMed
    12. Wood M, Ananthanarayanan M, Jones B, Wooton-Kee R, Hoffman T, Suchy FJ, Vore M. Hormonal regulation of hepatic organic anion transporting polypeptides. Mol Pharmacol. 2005 Jul; 68(1):218-25. PMID: 15840840.
      View in: PubMed
    13. Wooton-Kee CR, Boyanovsky BB, Nasser MS, de Villiers WJ, Webb NR. Group V sPLA2 hydrolysis of low-density lipoprotein results in spontaneous particle aggregation and promotes macrophage foam cell formation. Arterioscler Thromb Vasc Biol. 2004 Apr; 24(4):762-7. PMID: 14962950.
      View in: PubMed
    14. Tabb AL, Utsugi T, Wooten-Kee CR, Sasaki T, Edling SA, Gump W, Kikuchi Y, Ellis SR. Genes encoding ribosomal proteins Rps0A/B of Saccharomyces cerevisiae interact with TOM1 mutants defective in ribosome synthesis. Genetics. 2001 Mar; 157(3):1107-16. PMID: 11238398.
      View in: PubMed
    15. Wooton-Kee CR, Clark BJ. Steroidogenic factor-1 influences protein-deoxyribonucleic acid interactions within the cyclic adenosine 3,5-monophosphate-responsive regions of the murine steroidogenic acute regulatory protein gene. Endocrinology. 2000 Apr; 141(4):1345-55. PMID: 10746638.
      View in: PubMed
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