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CHOEL KIM

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pharmacology and Chemical Biology
DivisionPharmacology
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Biochemistry & Molecular Biology
    DivisionBiochemistry & Molecular Biology


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    R01GM090161     (KIM, CHOEL WOONG)Jul 1, 2010 - Jun 30, 2019
    NIH/NIGMS
    Activation and Regulation Mechanisms of cGMP-dependent Protein Kinase I and II
    Role: Principal Investigator

    R21HL111953     (KIM, CHOEL WOONG)Jul 17, 2012 - Jun 30, 2014
    NIH/NHLBI
    TARGETING CGMP KINASES TO DEVELOP NEW THERAPEUTICS FOR HYPERTENSIVE DISEASES
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chan MH, Aminzai S, Hu T, Taran A, Li S, Kim C, Pilz RB, Casteel DE. A substitution in cGMP-dependent protein kinase 1 associated with aortic disease induces an active conformation in the absence of cGMP. J Biol Chem. 2020 Jun 05. PMID: 32506052.
      View in: PubMed
    2. Kim C, Sharma R, Casteel DE. Correction to: Crystal structure of PKG Iß holoenzyme reveals a trans-inhibiting dimer assembly. J Transl Med. 2020 Jan 16; 18(1):27. PMID: 31948450.
      View in: PubMed
    3. Sutton MN, Huang GY, Liang X, Sharma R, Reger AS, Mao W, Pang L, Rask PJ, Lee K, Gray JP, Hurwitz AM, Palzkill T, Millward SW, Kim C, Lu Z, Bast RC. DIRAS3-Derived Peptide Inhibits Autophagy in Ovarian Cancer Cells by Binding to Beclin1. Cancers (Basel). 2019 Apr 18; 11(4). PMID: 31003488.
      View in: PubMed
    4. Qin L, Sankaran B, Aminzai S, Casteel DE, Kim C. Structural basis for selective inhibition of human PKG Ia by the balanol-like compound N46. J Biol Chem. 2018 07 13; 293(28):10985-10992. PMID: 29769318.
      View in: PubMed
    5. Campbell JC, VanSchouwen B, Lorenz R, Sankaran B, Herberg FW, Melacini G, Kim C. Crystal structure of cGMP-dependent protein kinase Iß cyclic nucleotide-binding-B domain : Rp-cGMPS complex reveals an apo-like, inactive conformation. FEBS Lett. 2017 Jan; 591(1):221-230. PMID: 27914169.
      View in: PubMed
    6. Cho KJ, Casteel DE, Prakash P, Tan L, van der Hoeven D, Salim AA, Kim C, Capon RJ, Lacey E, Cunha SR, Gorfe AA, Hancock JF. AMPK and Endothelial Nitric Oxide Synthase Signaling Regulates K-Ras Plasma Membrane Interactions via Cyclic GMP-Dependent Protein Kinase 2. Mol Cell Biol. 2016 12 15; 36(24):3086-3099. PMID: 27697864.
      View in: PubMed
    7. Campbell JC, Tischer A, Machha V, Moon-Tasson L, Sankaran B, Kim C, Auton M. Data on the purification and crystallization of the loss-of-function von Willebrand disease variant (p.Gly1324Ser) of the von Willebrand factor A1 domain. Data Brief. 2016 Jun; 7:1700-1706. PMID: 27761512.
      View in: PubMed
    8. Kim JJ, Lorenz R, Arold ST, Reger AS, Sankaran B, Casteel DE, Herberg FW, Kim C. Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation. Structure. 2016 05 03; 24(5):710-720. PMID: 27066748.
      View in: PubMed
    9. Campbell JC, Kim JJ, Li KY, Huang GY, Reger AS, Matsuda S, Sankaran B, Link TM, Yuasa K, Ladbury JE, Casteel DE, Kim C. Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II. J Biol Chem. 2016 Mar 11; 291(11):5623-33. PMID: 26769964.
      View in: PubMed
    10. Qin L, Reger AS, Guo E, Yang MP, Zwart P, Casteel DE, Kim C. Structures of cGMP-Dependent Protein Kinase (PKG) Ia Leucine Zippers Reveal an Interchain Disulfide Bond Important for Dimer Stability. Biochemistry. 2015 Jul 28; 54(29):4419-22. PMID: 26132214.
      View in: PubMed
    11. Reger AS, Yang MP, Koide-Yoshida S, Guo E, Mehta S, Yuasa K, Liu A, Casteel DE, Kim C. Crystal structure of the cGMP-dependent protein kinase II leucine zipper and Rab11b protein complex reveals molecular details of G-kinase-specific interactions. J Biol Chem. 2014 Sep 12; 289(37):25393-403. PMID: 25070890.
      View in: PubMed
    12. Campeau PM, Kasperaviciute D, Lu JT, Burrage LC, Kim C, Hori M, Powell BR, Stewart F, Félix TM, van den Ende J, Wisniewska M, Kayserili H, Rump P, Nampoothiri S, Aftimos S, Mey A, Nair LD, Begleiter ML, De Bie I, Meenakshi G, Murray ML, Repetto GM, Golabi M, Blair E, Male A, Giuliano F, Kariminejad A, Newman WG, Bhaskar SS, Dickerson JE, Kerr B, Banka S, Giltay JC, Wieczorek D, Tostevin A, Wiszniewska J, Cheung SW, Hennekam RC, Gibbs RA, Lee BH, Sisodiya SM. The genetic basis of DOORS syndrome: an exome-sequencing study. Lancet Neurol. 2014 Jan; 13(1):44-58. PMID: 24291220.
      View in: PubMed
    13. Huang GY, Kim JJ, Reger AS, Lorenz R, Moon EW, Zhao C, Casteel DE, Bertinetti D, Vanschouwen B, Selvaratnam R, Pflugrath JW, Sankaran B, Melacini G, Herberg FW, Kim C. Structural basis for cyclic-nucleotide selectivity and cGMP-selective activation of PKG I. Structure. 2014 Jan 07; 22(1):116-24. PMID: 24239458.
      View in: PubMed
    14. Guo DC, Regalado E, Casteel DE, Santos-Cortez RL, Gong L, Kim JJ, Dyack S, Horne SG, Chang G, Jondeau G, Boileau C, Coselli JS, Li Z, Leal SM, Shendure J, Rieder MJ, Bamshad MJ, Nickerson DA, Kim C, Milewicz DM. Recurrent gain-of-function mutation in PRKG1 causes thoracic aortic aneurysms and acute aortic dissections. Am J Hum Genet. 2013 Aug 08; 93(2):398-404. PMID: 23910461.
      View in: PubMed
    15. Kryshtafovych A, Moult J, Bartual SG, Bazan JF, Berman H, Casteel DE, Christodoulou E, Everett JK, Hausmann J, Heidebrecht T, Hills T, Hui R, Hunt JF, Seetharaman J, Joachimiak A, Kennedy MA, Kim C, Lingel A, Michalska K, Montelione GT, Otero JM, Perrakis A, Pizarro JC, van Raaij MJ, Ramelot TA, Rousseau F, Tong L, Wernimont AK, Young J, Schwede T. Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction. Proteins. 2011; 79 Suppl 10:6-20. PMID: 22020785.
      View in: PubMed
    16. Lee JH, Li S, Liu T, Hsu S, Kim C, Woods VL, Casteel DE. The amino terminus of cGMP-dependent protein kinase Iß increases the dynamics of the protein's cGMP-binding pockets. Int J Mass Spectrom. 2011 Apr 30; 302(1-3):44-52. PMID: 21643460.
      View in: PubMed
    17. Kim JJ, Casteel DE, Huang G, Kwon TH, Ren RK, Zwart P, Headd JJ, Brown NG, Chow DC, Palzkill T, Kim C. Co-crystal structures of PKG Iß (92-227) with cGMP and cAMP reveal the molecular details of cyclic-nucleotide binding. PLoS One. 2011 Apr 19; 6(4):e18413. PMID: 21526164.
      View in: PubMed
    18. Casteel DE, Smith-Nguyen EV, Sankaran B, Roh SH, Pilz RB, Kim C. A crystal structure of the cyclic GMP-dependent protein kinase I{beta} dimerization/docking domain reveals molecular details of isoform-specific anchoring. J Biol Chem. 2010 Oct 22; 285(43):32684-8. PMID: 20826808.
      View in: PubMed
    19. Kim C, Cheng CY, Saldanha SA, Taylor SS. PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation. Cell. 2007 Sep 21; 130(6):1032-43. PMID: 17889648.
      View in: PubMed
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